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Last Name
Institution

Clifford Woolf, Ph.D., M.B.,B.Ch.

TitleProfessor of Neurology
InstitutionChildren's Hospital Boston
DepartmentNeurology
AddressChildren's Hospital
F.M. Kirby Center and Program in Neurobiology, CLS12258
3 Blackfan Circle
Boston MA 02115
Phone617/919-2393
Fax617/919-2772
Other Positions
TitleProfessor of Neurobiology
InstitutionChildren's Hospital Boston
DepartmentNeurobiology


 Mentoring 
 current student opportunities
Available: 09/01/11, Expires: 07/31/14

The research in our group is devoted to investigating how the functional, chemical and structural plasticity of neurons contributes both to the normal adaptive functions of the nervous system and to the maladaptive changes that contribute to neurological diseases. Most of the work is concentrated on sensory and motor neurons using a multidisciplinary approach spanning molecular and cell biology, stem cell biology, electrophysiology, neuroanatomy, behavior, and genetics, with particular emphasis on the intersection between advances in basic science and its translation into new therapies. Our major focus is on the mechanisms that are responsible for producing pain and on the molecular determinants of the regeneration of the peripheral nervous system after injury. http://www.childrenshospital.org/cfapps/research/data_admin/Site2876/mainpageS2876P0.html http://www.hms.harvard.edu/dms/neuroscience/fac/woolf.html

 completed student projects
A Critical Period for Neuromuscular Junction Re-Establishment and Functional Recovery After Peripheral Nerve Injury in the Mouse
Full Time/Year Long, 09/01/12 - 05/31/13

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Woolf Lab - Mouse strains (29)
Transgenic Core Laboratory (CHB) - Core services (2) and Instruments (25)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. Br J Pharmacol. 2014 Jan; 171(2):438-51.
    View in: PubMed
  2. Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 5; 501(7465):52-7.
    View in: PubMed
  3. Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, Duan B, Oh SB, Bean BP, Ma Q, Binshtok AM, Woolf CJ. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci. 2013 May 19; 16(7):910-8.
    View in: PubMed
  4. Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL. A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS. Cell Stem Cell. 2013 Jun 6; 12(6):713-26.
    View in: PubMed
  5. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28; 495(7442):474-80.
    View in: PubMed
  6. Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr; 9(4):257-63.
    View in: PubMed
  7. Bruehl S, Apkarian AV, Ballantyne JC, Berger A, Borsook D, Chen WG, Farrar JT, Haythornthwaite JA, Horn SD, Iadarola MJ, Inturrisi CE, Lao L, Mackey S, Mao J, Sawczuk A, Uhl GR, Witter J, Woolf CJ, Zubieta JK, Lin Y. Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain. 2013 Feb; 14(2):103-13.
    View in: PubMed
  8. Puopolo M, Binshtok AM, Yao GL, Oh SB, Woolf CJ, Bean BP. Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol. 2013 Apr; 109(7):1704-12.
    View in: PubMed
  9. Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci. 2013 Jan 2; 33(1):315-26.
    View in: PubMed
  10. Woolf CJ. Pain: morphine, metabolites, mambas, and mutations. Lancet Neurol. 2013 Jan; 12(1):18-20.
    View in: PubMed
  11. Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet. 2012 Dec; 8(12):e1003071.
    View in: PubMed
  12. Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012 Aug; 15(8):1063-7.
    View in: PubMed
  13. Korngut L, Ma CH, Martinez JA, Toth CC, Guo GF, Singh V, Woolf CJ, Zochodne DW. Overexpression of human HSP27 protects sensory neurons from diabetes. Neurobiol Dis. 2012 Sep; 47(3):436-43.
    View in: PubMed
  14. Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci. 2012 May 2; 32(18):6364-72.
    View in: PubMed
  15. Hughes JP, Chessell I, Malamut R, Perkins M, Backonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, Segerdahl M, Seminowicz DA, Watkins LR, Waxman SG, Wiech K, Woolf C. Understanding chronic inflammatory and neuropathic pain. Ann N Y Acad Sci. 2012 May; 1255:30-44.
    View in: PubMed
  16. Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012 Apr; 18(4):595-9.
    View in: PubMed
  17. von Hehn CA, Baron R, Woolf CJ. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron. 2012 Feb 23; 73(4):638-52.
    View in: PubMed
  18. Cobos EJ, Ghasemlou N, Araldi D, Segal D, Duong K, Woolf CJ. Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia. Pain. 2012 Apr; 153(4):876-84.
    View in: PubMed
  19. Costigan M, Latremoliere A, Woolf CJ. Analgesia by inhibiting tetrahydrobiopterin synthesis. Curr Opin Pharmacol. 2012 Feb; 12(1):92-9.
    View in: PubMed
  20. Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA. The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci. 2011 Dec 14; 31(50):18391-400.
    View in: PubMed
  21. Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer MJ, Angioni C, Fleming I, Brandes RP, Reeh PW, Woolf CJ, Geisslinger G, Scholich K. Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation. Mol Pain. 2011; 7:78.
    View in: PubMed
  22. Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. J Clin Invest. 2011 Nov; 121(11):4332-47.
    View in: PubMed
  23. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 2011 Sep 2; 9(3):205-18.
    View in: PubMed
  24. Roberson DP, Binshtok AM, Blasl F, Bean BP, Woolf CJ. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. Br J Pharmacol. 2011 Sep; 164(1):48-58.
    View in: PubMed
  25. Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM. TrpA1 regulates thermal nociception in Drosophila. PLoS One. 2011; 6(8):e24343.
    View in: PubMed
  26. Dworkin RH, Turk DC, Basch E, Berger A, Cleeland C, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Markman J, Porter L, Raja SN, Ross E, Todd K, Wallace M, Woolf CJ. Considerations for extrapolating evidence of acute and chronic pain analgesic efficacy. Pain. 2011 Aug; 152(8):1705-8.
    View in: PubMed
  27. Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol. 2011 Mar; 29(3):279-86.
    View in: PubMed
  28. Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM. A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene. Cell. 2010 Nov 12; 143(4):628-38.
    View in: PubMed
  29. del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours M, Deering N, Brenner GJ, Costigan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM. TRPA1 contributes to cold hypersensitivity. J Neurosci. 2010 Nov 10; 30(45):15165-74.
    View in: PubMed
  30. Woolf CJ. What is this thing called pain? J Clin Invest. 2010 Nov; 120(11):3742-4.
    View in: PubMed
  31. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011 Mar; 152(3 Suppl):S2-15.
    View in: PubMed
  32. Woolf CJ. Overcoming obstacles to developing new analgesics. Nat Med. 2010 Nov; 16(11):1241-7.
    View in: PubMed
  33. Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, Wu T, Kiselycznyk C, Poddar M, Lu Y, Diatchenko L, Smith S, Cobos EJ, Zaykin D, Allchorne A, Gershon E, Livneh J, Shen PH, Nikolajsen L, Karppinen J, Männikkö M, Kelempisioti A, Goldman D, Maixner W, Geschwind DH, Max MB, Seltzer Z, Woolf CJ. Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain. 2010 Sep; 133(9):2519-27.
    View in: PubMed
  34. Latremoliere A, Woolf CJ. Synaptic plasticity and central sensitization: author reply. J Pain. 2010 Aug; 11(8):801-3.
    View in: PubMed
  35. Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25; 65(6):886-98.
    View in: PubMed
  36. Kim HY, Kim K, Li HY, Chung G, Park CK, Kim JS, Jung SJ, Lee MK, Ahn DK, Hwang SJ, Kang Y, Binshtok AM, Bean BP, Woolf CJ, Oh SB. Selectively targeting pain in the trigeminal system. Pain. 2010 Jul; 150(1):29-40.
    View in: PubMed
  37. Backonja M, Woolf CJ. Future directions in neuropathic pain therapy: closing the translational loop. Oncologist. 2010; 15 Suppl 2:24-9.
    View in: PubMed
  38. Eichler FS, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, Tamrazian E, Garofalo K, Lee HJ, Kini L, Selig M, Frosch M, Gable K, von Eckardstein A, Woolf CJ, Guan G, Harmon JM, Dunn TM, Brown RH. Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. J Neurosci. 2009 Nov 18; 29(46):14646-51.
    View in: PubMed
  39. Costigan M, Moss A, Latremoliere A, Johnston C, Verma-Gandhu M, Herbert TA, Barrett L, Brenner GJ, Vardeh D, Woolf CJ, Fitzgerald M. T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci. 2009 Nov 18; 29(46):14415-22.
    View in: PubMed
  40. Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009 Sep; 10(9):895-926.
    View in: PubMed
  41. Binshtok AM, Gerner P, Oh SB, Puopolo M, Suzuki S, Roberson DP, Herbert T, Wang CF, Kim D, Chung G, Mitani AA, Wang GK, Bean BP, Woolf CJ. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul; 111(1):127-37.
    View in: PubMed
  42. Woolf CJ. Mu and delta opioid receptors diverge. Cell. 2009 Jun 12; 137(6):987-8.
    View in: PubMed
  43. Scholz J, Mannion RJ, Hord DE, Griffin RS, Rawal B, Zheng H, Scoffings D, Phillips A, Guo J, Laing RJ, Abdi S, Decosterd I, Woolf CJ. A novel tool for the assessment of pain: validation in low back pain. PLoS Med. 2009 Apr 7; 6(4):e1000047.
    View in: PubMed
  44. Amaya F, Samad TA, Barrett L, Broom DC, Woolf CJ. Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion. Pain. 2009 Mar; 142(1-2):59-67.
    View in: PubMed
  45. Vardeh D, Wang D, Costigan M, Lazarus M, Saper CB, Woolf CJ, Fitzgerald GA, Samad TA. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest. 2009 Feb; 119(2):287-94.
    View in: PubMed
  46. Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov. 2009 Jan; 8(1):55-68.
    View in: PubMed
  47. Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009; 32:1-32.
    View in: PubMed
  48. Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA. Nociceptors are interleukin-1beta sensors. J Neurosci. 2008 Dec 24; 28(52):14062-73.
    View in: PubMed
  49. Gerner P, Binshtok AM, Wang CF, Hevelone ND, Bean BP, Woolf CJ, Wang GK. Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesthesiology. 2008 Nov; 109(5):872-8.
    View in: PubMed
  50. Antoniades C, Shirodaria C, Van Assche T, Cunnington C, Tegeder I, Lötsch J, Guzik TJ, Leeson P, Diesch J, Tousoulis D, Stefanadis C, Costigan M, Woolf CJ, Alp NJ, Channon KM. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. J Am Coll Cardiol. 2008 Jul 8; 52(2):158-65.
    View in: PubMed
  51. Woolf CJ. Novel analgesic development: from target to patient or patient to target? Curr Opin Investig Drugs. 2008 Jul; 9(7):694-5.
    View in: PubMed
  52. Kohno T, Wang H, Amaya F, Brenner GJ, Cheng JK, Ji RR, Woolf CJ. Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. J Neurosci. 2008 Apr 23; 28(17):4533-40.
    View in: PubMed
  53. Tegeder I, Adolph J, Schmidt H, Woolf CJ, Geisslinger G, Lötsch J. Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype. Eur J Pain. 2008 Nov; 12(8):1069-77.
    View in: PubMed
  54. Mills C, Makwana M, Wallace A, Benn S, Schmidt H, Tegeder I, Costigan M, Brown RH, Raivich G, Woolf CJ. Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats. Eur J Neurosci. 2008 Feb; 27(4):937-46.
    View in: PubMed
  55. Scholz J, Abele A, Marian C, Häussler A, Herbert TA, Woolf CJ, Tegeder I. Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats. Pain. 2008 Aug 15; 138(1):130-42.
    View in: PubMed
  56. Scholz J, Woolf CJ. The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci. 2007 Nov; 10(11):1361-8.
    View in: PubMed
  57. Binshtok AM, Bean BP, Woolf CJ. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature. 2007 Oct 4; 449(7162):607-10.
    View in: PubMed
  58. Griffin RS, Costigan M, Brenner GJ, Ma CH, Scholz J, Moss A, Allchorne AJ, Stahl GL, Woolf CJ. Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J Neurosci. 2007 Aug 8; 27(32):8699-708.
    View in: PubMed
  59. Woolf CJ, Ma Q. Nociceptors--noxious stimulus detectors. Neuron. 2007 Aug 2; 55(3):353-64.
    View in: PubMed
  60. Pertin M, Allchorne AJ, Beggah AT, Woolf CJ, Decosterd I. Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain. Mol Pain. 2007; 3:21.
    View in: PubMed
  61. Seijffers R, Mills CD, Woolf CJ. ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J Neurosci. 2007 Jul 25; 27(30):7911-20.
    View in: PubMed
  62. Mills CD, Allchorne AJ, Griffin RS, Woolf CJ, Costigan M. GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord. Mol Cell Neurosci. 2007 Oct; 36(2):185-94.
    View in: PubMed
  63. Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol. 2007 Jul; 9(7):755-64.
    View in: PubMed
  64. Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci. 2007 Jul; 10(7):870-9.
    View in: PubMed
  65. Woolf CJ. Central sensitization: uncovering the relation between pain and plasticity. Anesthesiology. 2007 Apr; 106(4):864-7.
    View in: PubMed
  66. Lötsch J, Belfer I, Kirchhof A, Mishra BK, Max MB, Doehring A, Costigan M, Woolf CJ, Geisslinger G, Tegeder I. Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms. Clin Chem. 2007 Jun; 53(6):1010-5.
    View in: PubMed
  67. Amaya F, Wang H, Costigan M, Allchorne AJ, Hatcher JP, Egerton J, Stean T, Morisset V, Grose D, Gunthorpe MJ, Chessell IP, Tate S, Green PJ, Woolf CJ. The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci. 2006 Dec 13; 26(50):12852-60.
    View in: PubMed
  68. Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med. 2006 Nov; 12(11):1269-77.
    View in: PubMed
  69. Lin CR, Amaya F, Barrett L, Wang H, Takada J, Samad TA, Woolf CJ. Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity. J Pharmacol Exp Ther. 2006 Dec; 319(3):1096-103.
    View in: PubMed
  70. Seijffers R, Allchorne AJ, Woolf CJ. The transcription factor ATF-3 promotes neurite outgrowth. Mol Cell Neurosci. 2006 May-Jun; 32(1-2):143-54.
    View in: PubMed
  71. Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006 May 13; 367(9522):1618-25.
    View in: PubMed
  72. Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006 Apr 20; 50(2):277-89.
    View in: PubMed
  73. Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006 May; 38(5):531-9.
    View in: PubMed
  74. Sarkar S, Woolf CJ, Hobson AR, Thompson DG, Aziz Q. Perceptual wind-up in the human oesophagus is enhanced by central sensitisation. Gut. 2006 Jul; 55(7):920-5.
    View in: PubMed
  75. Chen CL, Broom DC, Liu Y, de Nooij JC, Li Z, Cen C, Samad OA, Jessell TM, Woolf CJ, Ma Q. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006 Feb 2; 49(3):365-77.
    View in: PubMed
  76. Wang H, Ehnert C, Brenner GJ, Woolf CJ. Bradykinin and peripheral sensitization. Biol Chem. 2006 Jan; 387(1):11-4.
    View in: PubMed
  77. Allchorne AJ, Broom DC, Woolf CJ. Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats. Mol Pain. 2005; 1:36.
    View in: PubMed
  78. Kock N, Allchorne AJ, Sena-Esteves M, Woolf CJ, Breakefield XO. RNAi blocks DYT1 mutant torsinA inclusions in neurons. Neurosci Lett. 2006 Mar 13; 395(3):201-5.
    View in: PubMed
  79. Pertin M, Ji RR, Berta T, Powell AJ, Karchewski L, Tate SN, Isom LL, Woolf CJ, Gilliard N, Spahn DR, Decosterd I. Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. J Neurosci. 2005 Nov 23; 25(47):10970-80.
    View in: PubMed
  80. McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH. Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. Hum Mol Genet. 2005 Nov 15; 14(22):3507-21.
    View in: PubMed
  81. Mills CD, Bitler JL, Woolf CJ. Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. Mol Cell Neurosci. 2005 Oct; 30(2):228-37.
    View in: PubMed
  82. Kohno T, Ji RR, Ito N, Allchorne AJ, Befort K, Karchewski LA, Woolf CJ. Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. Pain. 2005 Sep; 117(1-2):77-87.
    View in: PubMed
  83. Wang H, Kohno T, Amaya F, Brenner GJ, Ito N, Allchorne A, Ji RR, Woolf CJ. Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci. 2005 Aug 31; 25(35):7986-92.
    View in: PubMed
  84. Willert RP, Delaney C, Hobson AR, Thompson DG, Woolf CJ, Aziz Q. Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity. Eur J Pain. 2006 Aug; 10(6):487-94.
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  203. Woolf CJ, Shortland P, Reynolds M, Ridings J, Doubell T, Coggeshall RE. Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy. J Comp Neurol. 1995 Sep 11; 360(1):121-34.
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  204. Safieh-Garabedian B, Poole S, Allchorne A, Winter J, Woolf CJ. Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br J Pharmacol. 1995 Aug; 115(7):1265-75.
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  205. Leslie TA, Emson PC, Dowd PM, Woolf CJ. Nerve growth factor contributes to the up-regulation of growth-associated protein 43 and preprotachykinin A messenger RNAs in primary sensory neurons following peripheral inflammation. Neuroscience. 1995 Aug; 67(3):753-61.
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  206. Woolf CJ. Somatic pain--pathogenesis and prevention. Br J Anaesth. 1995 Aug; 75(2):169-76.
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  207. Woolf CJ. An overview of the mechanisms of hyperalgesia. Pulm Pharmacol. 1995 Aug-Oct; 8(4-5):161-7.
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  208. Ma QP, Woolf CJ. Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones. J Physiol. 1995 Aug 1; 486 ( Pt 3):769-77.
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  209. Ma QP, Woolf CJ. Noxious stimuli induce an N-methyl-D-aspartate receptor-dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia. Pain. 1995 Jun; 61(3):383-90.
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  210. Collis R, Brandner B, Bromley LM, Woolf CJ. Is there any clinical advantage of increasing the pre-emptive dose of morphine or combining pre-incisional with postoperative morphine administration? Br J Anaesth. 1995 Apr; 74(4):396-9.
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  211. Bromley L, Richmond C, Brandner B, Woolf C. Pre-emptive analgesia. Anaesthesia. 1995 Feb; 50(2):176-7.
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  212. Sivilotti LG, Gerber G, Rawat B, Woolf CJ. Morphine selectively depresses the slowest, NMDA-independent component of C-fibre-evoked synaptic activity in the rat spinal cord in vitro. Eur J Neurosci. 1995 Jan 1; 7(1):12-8.
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  213. Hu-Tsai M, Winter J, Emson PC, Woolf CJ. Neurite outgrowth and GAP-43 mRNA expression in cultured adult rat dorsal root ganglion neurons: effects of NGF or prior peripheral axotomy. J Neurosci Res. 1994 Dec 15; 39(6):634-45.
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  214. Constantinou J, Reynolds ML, Woolf CJ, Safieh-Garabedian B, Fitzgerald M. Nerve growth factor levels in developing rat skin: upregulation following skin wounding. Neuroreport. 1994 Nov 21; 5(17):2281-4.
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  215. Nagy I, Miller BA, Woolf CJ. NK1 and NK2 receptors contribute to C-fibre evoked slow potentials in the spinal cord. Neuroreport. 1994 Oct 27; 5(16):2105-8.
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  216. Chong MS, Woolf CJ, Andrews P, Turmaine M, Schreyer DJ, Anderson PN. The downregulation of GAP-43 is not responsible for the failure of regeneration in freeze-killed nerve grafts in the rat. Exp Neurol. 1994 Oct; 129(2):311-20.
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  217. Woolf CJ, Safieh-Garabedian B, Ma QP, Crilly P, Winter J. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience. 1994 Sep; 62(2):327-31.
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  218. Woolf CJ, Shortland P, Sivilotti LG. Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation. Pain. 1994 Aug; 58(2):141-55.
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  219. Woolf CJ, Doubell TP. The pathophysiology of chronic pain--increased sensitivity to low threshold A beta-fibre inputs. Curr Opin Neurobiol. 1994 Aug; 4(4):525-34.
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  220. Sivilotti L, Woolf CJ. The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J Neurophysiol. 1994 Jul; 72(1):169-79.
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  221. Chong MS, Reynolds ML, Irwin N, Coggeshall RE, Emson PC, Benowitz LI, Woolf CJ. GAP-43 expression in primary sensory neurons following central axotomy. J Neurosci. 1994 Jul; 14(7):4375-84.
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  222. Nagy I, Woolf CJ, Dray A, Urbán L. Cobalt accumulation in neurons expressing ionotropic excitatory amino acid receptors in young rat spinal cord: morphology and distribution. J Comp Neurol. 1994 Jun 15; 344(3):321-35.
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  223. Woolf CJ. A new strategy for the treatment of inflammatory pain. Prevention or elimination of central sensitization. Drugs. 1994; 47 Suppl 5:1-9; discussion 46-7.
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  224. Mehta A, Reynolds ML, Woolf CJ. Partial denervation of the medial gastrocnemius muscle results in growth-associated protein-43 immunoreactivity in sprouting axons and Schwann cells. Neuroscience. 1993 Nov; 57(2):433-42.
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  225. Reynolds ML, Woolf CJ. Reciprocal Schwann cell-axon interactions. Curr Opin Neurobiol. 1993 Oct; 3(5):683-93.
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  226. Nagy I, Pabla R, Matesz C, Dray A, Woolf CJ, Urban L. Cobalt uptake enables identification of capsaicin- and bradykinin-sensitive subpopulations of rat dorsal root ganglion cells in vitro. Neuroscience. 1993 Sep; 56(1):241-6.
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  227. Woolf CJ, Chong MS. Preemptive analgesia--treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg. 1993 Aug; 77(2):362-79.
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  228. Richmond CE, Bromley LM, Woolf CJ. Preoperative morphine pre-empts postoperative pain. Lancet. 1993 Jul 10; 342(8863):73-5.
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  229. Thompson SW, Woolf CJ, Sivilotti LG. Small-caliber afferent inputs produce a heterosynaptic facilitation of the synaptic responses evoked by primary afferent A-fibers in the neonatal rat spinal cord in vitro. J Neurophysiol. 1993 Jun; 69(6):2116-28.
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  230. Sivilotti LG, Thompson SW, Woolf CJ. Rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-caliber afferents is a predictor of action potential windup in rat spinal neurons in vitro. J Neurophysiol. 1993 May; 69(5):1621-31.
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  231. Nagy I, Urban L, Woolf CJ. Morphological and membrane properties of young rat lumbar and thoracic dorsal root ganglion cells with unmyelinated axons. Brain Res. 1993 Apr 23; 609(1-2):193-200.
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  232. Shortland P, Woolf CJ. Chronic peripheral nerve section results in a rearrangement of the central axonal arborizations of axotomized A beta primary afferent neurons in the rat spinal cord. J Comp Neurol. 1993 Apr 1; 330(1):65-82.
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  233. Shortland P, Woolf CJ. Morphology and somatotopy of the central arborizations of rapidly adapting glabrous skin afferents in the rat lumbar spinal cord. J Comp Neurol. 1993 Mar 22; 329(4):491-511.
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  234. Nagy I, Maggi CA, Dray A, Woolf CJ, Urban L. The role of neurokinin and N-methyl-D-aspartate receptors in synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro. Neuroscience. 1993 Feb; 52(4):1029-37.
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  235. Woolf CJ. The pathophysiology of peripheral neuropathic pain--abnormal peripheral input and abnormal central processing. Acta Neurochir Suppl (Wien). 1993; 58:125-30.
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  236. Woolf CJ. Factors controlling the expression of GAP-43 in dorsal root ganglia cells: implications for plasticity and growth of central terminals. Restor Neurol Neurosci. 1993 Jan 1; 5(1):51-2.
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  237. Thompson SW, Gerber G, Sivilotti LG, Woolf CJ. Long duration ventral root potentials in the neonatal rat spinal cord in vitro; the effects of ionotropic and metabotropic excitatory amino acid receptor antagonists. Brain Res. 1992 Nov 6; 595(1):87-97.
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  238. Winter J, Evison CJ, O'Brien C, Benowitz L, Lindsay RM, Mulderry P, Woolf C. Neurotoxic damage evokes regenerative responses from adult rat sensory neurones. Neurosci Lett. 1992 Oct 26; 146(1):48-52.
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  239. Woolf CJ, Reynolds ML, Chong MS, Emson P, Irwin N, Benowitz LI. Denervation of the motor endplate results in the rapid expression by terminal Schwann cells of the growth-associated protein GAP-43. J Neurosci. 1992 Oct; 12(10):3999-4010.
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  240. Hu-Tsai M, Winter J, Woolf CJ. Regional differences in the distribution of capsaicin-sensitive target-identified adult rat dorsal root ganglion neurons. Neurosci Lett. 1992 Aug 31; 143(1-2):251-4.
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  241. Woolf CJ, Shortland P, Coggeshall RE. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature. 1992 Jan 2; 355(6355):75-8.
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  242. Chong MS, Fitzgerald M, Winter J, Hu-Tsai M, Emson PC, Wiese U, Woolf CJ. GAP-43 mRNA in Rat Spinal Cord and Dorsal Root Ganglia Neurons: Developmental Changes and Re-expression Following Peripheral Nerve Injury. Eur J Neurosci. 1992; 4(10):883-95.
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  243. Reynolds ML, Woolf CJ. Terminal Schwann cells elaborate extensive processes following denervation of the motor endplate. J Neurocytol. 1992 Jan; 21(1):50-66.
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  244. Coggeshall RE, Reynolds ML, Woolf CJ. Distribution of the growth associated protein GAP-43 in the central processes of axotomized primary afferents in the adult rat spinal cord; presence of growth cone-like structures. Neurosci Lett. 1991 Sep 30; 131(1):37-41.
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  245. Woolf CJ. Generation of acute pain: central mechanisms. Br Med Bull. 1991 Jul; 47(3):523-33.
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  246. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain. 1991 Mar; 44(3):293-9.
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  247. Woolf CJ, Walters ET. Common patterns of plasticity contributing to nociceptive sensitization in mammals and Aplysia. Trends Neurosci. 1991 Feb; 14(2):74-8.
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  248. Sommervaille T, Reynolds ML, Woolf CJ. Time-dependent differences in the increase in GAP-43 expression in dorsal root ganglion cells after peripheral axotomy. Neuroscience. 1991; 45(1):213-20.
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  249. Fitzgerald M, Woolf CJ, Shortland P. Collateral sprouting of the central terminals of cutaneous primary afferent neurons in the rat spinal cord: pattern, morphology, and influence of targets. J Comp Neurol. 1990 Oct 15; 300(3):370-85.
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  250. King AE, Thompson SW, Woolf CJ. Characterization of the cutaneous input to the ventral horn in vitro using the isolated spinal cord-hind limb preparation. J Neurosci Methods. 1990 Oct; 35(1):39-46.
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  251. Woolf CJ, King AE. Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord. J Neurosci. 1990 Aug; 10(8):2717-26.
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  252. Shortland P, Molander C, Woolf CJ, Fitzgerald M. Neonatal capsaicin treatment induces invasion of the substantia gelatinosa by the terminal arborizations of hair follicle afferents in the rat dorsal horn. J Comp Neurol. 1990 Jun 1; 296(1):23-31.
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  253. Thompson SW, King AE, Woolf CJ. Activity-Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a d-2-Amino-5-Phosphonovaleric Acid Sensitive Windup. Eur J Neurosci. 1990; 2(7):638-49.
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  254. Woolf CJ, Reynolds ML, Molander C, O'Brien C, Lindsay RM, Benowitz LI. The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury. Neuroscience. 1990; 34(2):465-78.
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  255. Shortland P, Woolf CJ, Fitzgerald M. Morphology and somatotopic organization of the central terminals of hindlimb hair follicle afferents in the rat lumbar spinal cord. J Comp Neurol. 1989 Nov 15; 289(3):416-33.
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  256. Woolf CJ, King AE. Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord. J Neurophysiol. 1989 Oct; 62(4):907-16.
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  257. Woolf CJ. Recent advances in the pathophysiology of acute pain. Br J Anaesth. 1989 Aug; 63(2):139-46.
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  258. O'Brien C, Woolf CJ, Fitzgerald M, Lindsay RM, Molander C. Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint. Neuroscience. 1989; 32(2):493-502.
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  259. Millard CL, Woolf CJ. Sensory innervation of the hairs of the rat hindlimb: a light microscopic analysis. J Comp Neurol. 1988 Nov 8; 277(2):183-94.
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  260. King AE, Thompson SW, Urban L, Woolf CJ. The responses recorded in vitro of deep dorsal horn neurons to direct and orthodromic stimulation in the young rat spinal cord. Neuroscience. 1988 Oct; 27(1):231-42.
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  261. King AE, Thompson SW, Urban L, Woolf CJ. An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice. Neurosci Lett. 1988 Jul 8; 89(3):286-92.
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  262. Woolf CJ, Thompson SW, King AE. Prolonged primary afferent induced alterations in dorsal horn neurones, an intracellular analysis in vivo and in vitro. J Physiol (Paris). 1988-1989; 83(3):255-66.
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  263. Woolf CJ, King AE. Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord. J Neurophysiol. 1987 Sep; 58(3):460-79.
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  264. Fitzgerald M, King AE, Thompson SW, Woolf CJ. The postnatal development of the ventral root reflex in the rat; a comparative in vivo and in vitro study. Neurosci Lett. 1987 Jul 9; 78(1):41-5.
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  265. Woolf CJ. Central terminations of cutaneous mechanoreceptive afferents in the rat lumbar spinal cord. J Comp Neurol. 1987 Jul 1; 261(1):105-19.
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  266. Woolf CJ. Excitatory amino acids increase glycogen phosphorylase activity in the rat spinal cord. Neurosci Lett. 1987 Jan 27; 73(3):209-14.
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  267. Cook AJ, Woolf CJ, Wall PD, McMahon SB. Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input. Nature. 1987 Jan 8-14; 325(7000):151-3.
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  268. Woolf CJ. Physiological, inflammatory and neuropathic pain. Adv Tech Stand Neurosurg. 1987; 15:39-62.
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  269. Cook AJ, Woolf CJ, Wall PD. Prolonged C-fibre mediated facilitation of the flexion reflex in the rat is not due to changes in afferent terminal or motoneurone excitability. Neurosci Lett. 1986 Sep 25; 70(1):91-6.
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  270. Woolf CJ, Fitzgerald M. Somatotopic organization of cutaneous afferent terminals and dorsal horn neuronal receptive fields in the superficial and deep laminae of the rat lumbar spinal cord. J Comp Neurol. 1986 Sep 22; 251(4):517-31.
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  271. Woolf C, Wiesenfeld-Hallin Z. Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat. Neurosci Lett. 1986 May 15; 66(2):226-30.
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  272. Woolf CJ, Wall PD. Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat. J Neurosci. 1986 May; 6(5):1433-42.
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  273. Wall PD, Woolf CJ. The brief and the prolonged facilitatory effects of unmyelinated afferent input on the rat spinal cord are independently influenced by peripheral nerve section. Neuroscience. 1986 Apr; 17(4):1199-205.
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  274. Woolf CJ, Wall PD. Morphine-sensitive and morphine-insensitive actions of C-fibre input on the rat spinal cord. Neurosci Lett. 1986 Feb 28; 64(2):221-5.
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  275. Woolf CJ, Wiesenfeld-Hallin Z. The systemic administration of local anaesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord. Pain. 1985 Dec; 23(4):361-74.
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  276. Woolf CJ, McMahon SB. Injury-induced plasticity of the flexor reflex in chronic decerebrate rats. Neuroscience. 1985 Oct; 16(2):395-404.
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  277. Cook AJ, Woolf CJ. Cutaneous receptive field and morphological properties of hamstring flexor alpha-motoneurones in the rat. J Physiol. 1985 Jul; 364:249-63.
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  278. Woolf CJ, Chong MS, Rashdi TA. Mapping increased glycogen phosphorylase activity in dorsal root ganglia and in the spinal cord following peripheral stimuli. J Comp Neurol. 1985 Apr 1; 234(1):60-76.
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  279. Swett JE, Woolf CJ. The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord. J Comp Neurol. 1985 Jan 1; 231(1):66-77.
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  280. McMahon SB, Sykova E, Wall PD, Woolf CJ, Gibson SJ. Neurogenic extravasation and substance P levels are low in muscle as compared to skin the rat hindlimb. Neurosci Lett. 1984 Dec 21; 52(3):235-40.
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  281. Wall PD, Woolf CJ. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. J Physiol. 1984 Nov; 356:443-58.
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  282. Woolf CJ, Chong MS, Ainsworth A. Axotomy increases glycogen phosphorylase activity in motoneurones. Neuroscience. 1984 Aug; 12(4):1261-9.
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  283. Woolf CJ, Swett JE. The cutaneous contribution to the hamstring flexor reflex in the rat: an electrophysiological and anatomical study. Brain Res. 1984 Jun 15; 303(2):299-312.
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  284. Woolf CJ. Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat. Pain. 1984 Apr; 18(4):325-43.
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  285. Woolf CJ. A selective effect of naloxone on heterosynaptic C-fibre-mediated inhibitions in the rat dorsal horn. Neurosci Lett. 1984 Mar 23; 45(2):169-74.
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  286. Fitzgerald M, Woolf CJ, Gibson SJ, Mallaburn PS. Alterations in the structure, function, and chemistry of C fibers following local application of vinblastine to the sciatic nerve of the rat. J Neurosci. 1984 Feb; 4(2):430-41.
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  287. Woolf CJ, Fitzgerald M. The properties of neurones recorded in the superficial dorsal horn of the rat spinal cord. J Comp Neurol. 1983 Dec 10; 221(3):313-28.
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  288. Woolf CJ, Wall PD. Endogenous opioid peptides and pain mechanisms: a complex relationship. Nature. 1983 Dec 22-1984 Jan 4; 306(5945):739-40.
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  289. Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature. 1983 Dec 15-21; 306(5944):686-8.
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  290. Woolf CJ. C-primary afferent fibre mediated inhibitions in the dorsal horn of the decerebrate-spinal rat. Exp Brain Res. 1983; 51(2):283-90.
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  291. Wall PD, Fitzgerald M, Woolf CJ. Effects of capsaicin on receptive fields and on inhibitions in rat spinal cord. Exp Neurol. 1982 Nov; 78(2):425-36.
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  292. Woolf CJ, Wall PD. Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones. Brain Res. 1982 Jun 17; 242(1):77-85.
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  293. Woolf CJ, Fitzgerald M. Do opioid peptides mediate a presynaptic control of C-fibre transmission in the rat spinal cord? Neurosci Lett. 1982 Mar 17; 29(1):67-72.
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  294. Fitzgerald M, Woolf CJ. The time course and specificity of the changes in the behavioural and dorsal horn cell responses to noxious stimuli following peripheral nerve capsaicin treatment in the rat. Neuroscience. 1982; 7(9):2051-6.
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  295. Fitzgerald M, Woolf CJ. Effects of cutaneous nerve and intraspinal conditioning of C-fibre afferent terminal excitability in decerebrate spinal rats. J Physiol. 1981 Sep; 318:25-39.
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  296. Woolf CJ, Fitzgerald M. Lamina-specific alteration of C-fibre evoked activity by morphine in the dorsal horn of the rat spinal cord. Neurosci Lett. 1981 Aug 7; 25(1):37-41.
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  297. Dickenson AH, Hellon RF, Woolf CJ. Tooth pulp input to the spinal trigeminal nucleus: a comparison of inhibitions following segmental and raphe magnus stimulation. Brain Res. 1981 Jun 9; 214(1):73-87.
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  298. Dawson NJ, Dickenson AH, Hellon RF, Woolf CJ. Inhibitory controls on thermal neurones in the spinal trigeminal nucleus of cats and rats. Brain Res. 1981 Mar 30; 209(2):440-5.
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  299. Woolf CJ. Intrathecal high dose morphine produces hyperalgesia in the rat. Brain Res. 1981 Mar 30; 209(2):491-5.
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  300. Aziz LA, Forsling ML, Woolf CJ. The effect of intracerebroventricular injections of morphine on vasopressin release in the rat. J Physiol. 1981 Feb; 311:401-9.
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  301. Fitzgerald M, Woolf CJ. The stereospecific effect of naloxone on rat dorsal horn neurones; inhibition in superficial laminae and excitation in deeper laminae. Pain. 1980 Dec; 9(3):293-306.
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  302. Wall PD, Woolf CJ. What we don't know about pain. Nature. 1980 Sep 18; 287(5779):185-6.
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  303. Woolf CJ. Intracerebral naloxone and the reaction to thermal noxious stimulation in the rat. Brain Res. 1980 May 26; 190(2):578-83.
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  304. Woolf CJ. Analgesia and hyperalgesia produced in the rat by intrathecal naloxone. Brain Res. 1980 May 12; 189(2):593-7.
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  305. Woolf CJ, Mitchell D, Barrett GD. Antinociceptive effect of peripheral segmental electrical stimulation in the rat. Pain. 1980 Apr; 8(2):237-52.
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  306. Willies GH, Woolf CJ. The site of action of corticosteroid antipyresis in the rabbit. J Physiol. 1980 Mar; 300:1-6.
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  307. Woolf CJ. Transcutaneous electrical nerve stimulation and the reaction to experimental pain in human subjects. Pain. 1979 Oct; 7(2):115-27.
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  308. Mitchell D, Woolf CJ. Descending tryptaminergic pathways and the antinociceptive effect produced by peripheral electrical stimulation in the rat [proceedings]. J Physiol. 1979 Aug; 293:59P-60P.
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  309. Chandler HD, Woolf CJ, Hepburn HR. Gliding edge dislocations in proteins as a mechanism for active ion transport. Biochem J. 1978 Mar 1; 169(3):559-65.
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  310. Woolf CJ, Mitchell D, Myers RA, Barrett GD. Failure of naloxone to reverse peripheral transcutaneous electro-analgesia in patients suffering from acute trauma. S Afr Med J. 1978 Feb 4; 53(5):179-80.
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  311. Woolf CJ, Barrett GD, Mitchell D, Myers RA. Naloxone-reversible peripheral electroanalgesia in intact and spinal rats. Eur J Pharmacol. 1977 Oct 1; 45(3):311-4.
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  312. Myers RA, Woolf CJ, Mitchell D. Management of acute traumatic pain by peripheral transcutaneous electrical stimulation. S Afr Med J. 1977 Aug 13; 52(8):309-12.
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  313. Borsook D, Laburn HP, Rosendorff C, Willies GH, Woolf CJ. A dissociation between temperature regulation and fever in the rabbit. J Physiol. 1977 Apr; 266(2):423-33.
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  314. Willies GH, Woolf CJ, Rosendorff C. The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit. Pflugers Arch. 1976 Dec 28; 367(2):177-81.
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  315. Woolf CJ, Willies GH, Rosendorff C. Does cyclic AMP have a role in the pathogenesis of fever in the rabbit? Naturwissenschaften. 1976 Feb; 63(2):94-5.
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  316. Willies GH, Woolf CJ, Rosendorff C. The effect of sodium salicylate on dibutyryl cyclic AMP fever in the conscious rabbit. Neuropharmacology. 1976 Jan; 15(1):9-10.
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  317. Laburn H, Woolf CJ, Willies GH, Rosendorff C. Pyrogen and prostaglandin fever in the rabbit-II: Effects of noradrenaline depletion and adrenergic receptor blockade. Neuropharmacology. 1975 May-Jun; 14(5-6):405-11.
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  318. Woolf CJ, Willies GH, Laburn H, Rosendorff C. Pyrogen and prostaglandin fever in the rabbit-I: Effects of salicylate and the role of cyclic AMP. Neuropharmacology. 1975 May-Jun; 14(5-6):397-403.
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  319. Woolf CJ, Laburn HP, Willies GH, Rosendorff C. Hypothalamic heating and cooling in monoamine-depleted rabbits. Am J Physiol. 1975 Feb; 228(2):569-74.
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  320. Woolf CJ, Willies GH, Hepburn HR, Rosendorff C. Time dependence of a neurochemical correlate of a learning task: a non-disruptive approach to memory consolidation. Experientia. 1974 Jul 15; 30(7):760-2.
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  321. Laburn HP, Rosendorff C, Willies G, Woolf C. Proceedings: A role for noradrenaline and cyclic AMP in prostaglandin E1 Fever. J Physiol. 1974 Jul; 240(2):49P-50P.
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  322. Suero JT, Woolf CR. Alterations in the mechanical properties of the lung during dyspnea in chronic obstructive pulmonary disease. J Clin Invest. 1970 Apr; 49(4):747-51.
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