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Keywords
Last Name
Institution

George Liang King, M.D.

TitleProfessor of Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Research Lab
One Joslin Place
Boston MA 02215
Phone617/732-2622
Fax617/732-2637

 Mentoring 
 completed student projects
Role of Insulin and PKC activation in monocytes differentiation and the development of atherosclerosis
Summer, 06/20/05 - 09/01/05

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Turek SJ, Hastings SM, Sun JK, King GL, Keenan HA. Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes. Diabetes Care. 2013 Oct; 36(10):3222-6.
    View in: PubMed
  2. Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41.
    View in: PubMed
  3. Le H, Wong S, Iftikar T, Keenan H, King GL, Hsu WC. Characterization of factors affecting attainment of glycemic control in asian americans with diabetes in a culturally specific program. Diabetes Educ. 2013 Jul-Aug; 39(4):468-77.
    View in: PubMed
  4. Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL. Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-ß Isoform in the Endothelium. Circ Res. 2013 Aug 2; 113(4):418-27.
    View in: PubMed
  5. Fukuzawa T, Fukazawa M, Ueda O, Shimada H, Kito A, Kakefuda M, Kawase Y, Wada NA, Goto C, Fukushima N, Jishage K, Honda K, King GL, Kawabe Y. SGLT5 Reabsorbs Fructose in the Kidney but Its Deficiency Paradoxically Exacerbates Hepatic Steatosis Induced by Fructose. PLoS One. 2013; 8(2):e56681.
    View in: PubMed
  6. Rask-Madsen C, King GL. Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab. 2013 Jan 8; 17(1):20-33.
    View in: PubMed
  7. Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Keith Blackwell T, Makino T. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med. 2013 Dec; 65:1506-15.
    View in: PubMed
  8. Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec; 53(13):8424-32.
    View in: PubMed
  9. Mima A, Qi W, King GL. Implications of treatment that target protective mechanisms against diabetic nephropathy. Semin Nephrol. 2012 Sep; 32(5):471-8.
    View in: PubMed
  10. Glazer NL, Macy EM, Lumley T, Smith NL, Reiner AP, Psaty BM, King GL, Tracy RP, Siscovick DS. Transforming growth factor beta-1 and incidence of heart failure in older adults: the Cardiovascular Health Study. Cytokine. 2012 Nov; 60(2):341-5.
    View in: PubMed
  11. Mima A, Hiraoka-Yamomoto J, Li Q, Kitada M, Li C, Geraldes P, Matsumoto M, Mizutani K, Park K, Cahill C, Nishikawa S, Rask-Madsen C, King GL. Protective Effects of GLP-1 on Glomerular Endothelium and Its Inhibition by PKCß Activation in Diabetes. Diabetes. 2012 Nov; 61(11):2967-79.
    View in: PubMed
  12. Hsu WC, Boyko EJ, Fujimoto WY, Kanaya A, Karmally W, Karter A, King GL, Look M, Maskarinec G, Misra R, Tavake-Pasi F, Arakaki R. Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications. Diabetes Care. 2012 May; 35(5):1189-98.
    View in: PubMed
  13. King GL, McNeely MJ, Thorpe LE, Mau ML, Ko J, Liu LL, Sun A, Hsu WC, Chow EA. Understanding and addressing unique needs of diabetes in Asian Americans, native Hawaiians, and Pacific Islanders. Diabetes Care. 2012 May; 35(5):1181-8.
    View in: PubMed
  14. Mima A, Kitada M, Geraldes P, Li Q, Matsumoto M, Mizutani K, Qi W, Li C, Leitges M, Rask-Madsen C, King GL. Glomerular VEGF resistance induced by PKCd/SHP-1 activation and contribution to diabetic nephropathy. FASEB J. 2012 Jul; 26(7):2963-74.
    View in: PubMed
  15. Rask-Madsen C, Buonomo E, Li Q, Park K, Clermont AC, Yerokun O, Rekhter M, King GL. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1124-31.
    View in: PubMed
  16. Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30.
    View in: PubMed
  17. Hsu WC, Okeke E, Cheung S, Keenan H, Tsui T, Cheng K, King GL. A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes. PLoS One. 2011; 6(12):e28311.
    View in: PubMed
  18. Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17.
    View in: PubMed
  19. Sun JK, Keenan HA, Cavallerano JD, Asztalos BF, Schaefer EJ, Sell DR, Strauch CM, Monnier VM, Doria A, Aiello LP, King GL. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study. Diabetes Care. 2011 Apr; 34(4):968-74.
    View in: PubMed
  20. Rask-Madsen C, King GL. Endothelium-dependent delivery of insulin to muscle interstitium. Cell Metab. 2011 Mar 2; 13(3):236-8.
    View in: PubMed
  21. Jeong IK, King GL. New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia. Diabetes Metab J. 2011 Feb; 35(1):8-11.
    View in: PubMed
  22. Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL. Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int. 2011 Apr; 79(8):883-96.
    View in: PubMed
  23. Stanton RC, King GL. A complex interplay of factors causes diabetic nephropathy. Metabolism. 2011 May; 60(5):591-3.
    View in: PubMed
  24. Rask-Madsen C, King GL. Diabetes: Podocytes lose their footing. Nature. 2010 Nov 4; 468(7320):42-4.
    View in: PubMed
  25. Cao L, Arany PR, Kim J, Rivera-Feliciano J, Wang YS, He Z, Rask-Madsen C, King GL, Mooney DJ. Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials. 2010 Dec; 31(34):9048-56.
    View in: PubMed
  26. Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GL. Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010 Nov; 59(11):2846-53.
    View in: PubMed
  27. Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dall'Osso C, Wagers AJ, Huang PL, Rekhter M, Scalia R, Kahn CR, King GL. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 5; 11(5):379-89.
    View in: PubMed
  28. Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010 Apr 30; 106(8):1319-31.
    View in: PubMed
  29. Rask-Madsen C, King GL. Kidney complications: factors that protect the diabetic vasculature. Nat Med. 2010 Jan; 16(1):40-1.
    View in: PubMed
  30. Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009 Nov; 15(11):1298-306.
    View in: PubMed
  31. Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90.
    View in: PubMed
  32. Rigor DL, Bodyak N, Bae S, Choi JH, Zhang L, Ter-Ovanesyan D, He Z, McMullen JR, Shioi T, Izumo S, King GL, Kang PM. Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H566-72.
    View in: PubMed
  33. Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 5; 283(49):34327-36.
    View in: PubMed
  34. Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43.
    View in: PubMed
  35. King GL. The role of inflammatory cytokines in diabetes and its complications. J Periodontol. 2008 Aug; 79(8 Suppl):1527-34.
    View in: PubMed
  36. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6998-7003.
    View in: PubMed
  37. Rask-Madsen C, King GL. More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes. Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):608-10.
    View in: PubMed
  38. Rask-Madsen C, King GL. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):919-24.
    View in: PubMed
  39. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008 Feb; 7(2):125-34.
    View in: PubMed
  40. Geraldes P, Yamagata M, Rook SL, Sassa Y, Ma RC, Clermont A, Gao B, Aiello LP, Feener EP, King GL. Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5750-5.
    View in: PubMed
  41. Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, Coney J, Orchard TJ, Aiello LP, King GL. Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care. 2007 Aug; 30(8):1995-7.
    View in: PubMed
  42. Das Evcimen N, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007 Jun; 55(6):498-510.
    View in: PubMed
  43. Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20.
    View in: PubMed
  44. Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8.
    View in: PubMed
  45. Rask-Madsen C, King GL. Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab. 2007 Jan; 3(1):46-56.
    View in: PubMed
  46. Engelgau MM, Vinicor F, Simionescu M, King GL, Meininger C, Mensah GA. Summary statement IV: Obesity and diabetes: opportunities for translation of basic research. Vascul Pharmacol. 2007 May; 46(5):324-6.
    View in: PubMed
  47. McGill JB, King GL, Berg PH, Price KL, Kles KA, Bastyr EJ, Hyslop DL. Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin. Expert Opin Drug Saf. 2006 Nov; 5(6):835-45.
    View in: PubMed
  48. Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 2006 Nov; 55(11):3112-20.
    View in: PubMed
  49. Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL. Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J. 2006 Oct; 20(12):2058-67.
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  50. Sotiropoulos KB, Clermont A, Yasuda Y, Rask-Madsen C, Mastumoto M, Takahashi J, Della Vecchia K, Kondo T, Aiello LP, King GL. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J. 2006 Jun; 20(8):1203-5.
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  51. Naruse K, Rask-Madsen C, Takahara N, Ha SW, Suzuma K, Way KJ, Jacobs JR, Clermont AC, Ueki K, Ohshiro Y, Zhang J, Goldfine AB, King GL. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar; 55(3):691-8.
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  52. He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93.
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  53. Hsu WC, Cheung S, Ong E, Wong K, Lin S, Leon K, Weinger K, King GL. Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes. Diabetes Care. 2006 Feb; 29(2):415-6.
    View in: PubMed
  54. He Z, King GL. Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients? Diabetes Care. 2005 Nov; 28(11):2803-5.
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  55. Ahmad FK, He Z, King GL. Molecular targets of diabetic cardiovascular complications. Curr Drug Targets. 2005 Jun; 6(4):487-94.
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  56. Itoh S, Ding B, Bains CP, Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, Abe J. Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem. 2005 Jun 24; 280(25):24135-42.
    View in: PubMed
  57. Xu Y, He Z, King GL. Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications. Curr Diab Rep. 2005 Apr; 5(2):91-7.
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  58. He Z, Way KJ, Arikawa E, Chou E, Opland DM, Clermont A, Isshiki K, Ma RC, Scott JA, Schoen FJ, Feener EP, King GL. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem. 2005 Apr 22; 280(16):15719-26.
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  59. Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 2; 25(5):1240-8.
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  60. Rask-Madsen C, King GL. Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):487-96.
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  61. Economides PA, Khaodhiar L, Caselli A, Caballero AE, Keenan H, Bursell SE, King GL, Johnstone MT, Horton ES, Veves A. The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients. Diabetes. 2005 Jan; 54(1):204-11.
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  62. Scott JA, King GL. Oxidative stress and antioxidant treatment in diabetes. Ann N Y Acad Sci. 2004 Dec; 1031:204-13.
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  63. Treszl A, Szereday L, Doria A, King GL, Orban T. Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes. Diabetes Care. 2004 Nov; 27(11):2769-70.
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  64. King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol. 2004 Oct; 122(4):333-8.
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  65. He Z, King GL. Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases. Circulation. 2004 Jul 6; 110(1):7-9.
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  66. Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem. 2004 Jul 16; 279(29):30369-74.
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  67. He Z, King GL. Microvascular complications of diabetes. Endocrinol Metab Clin North Am. 2004 Mar; 33(1):215-38, xi-xii.
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  68. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Retinopathy in diabetes. Diabetes Care. 2004 Jan; 27 Suppl 1:S84-7.
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  69. Kuroki T, Isshiki K, King GL. Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications. J Am Soc Nephrol. 2003 Aug; 14(8 Suppl 3):S216-20.
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  70. Kondo T, Vicent D, Suzuma K, Yanagisawa M, King GL, Holzenberger M, Kahn CR. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest. 2003 Jun; 111(12):1835-42.
    View in: PubMed
  71. Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):31964-71.
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  72. Vicent D, Ilany J, Kondo T, Naruse K, Fisher SJ, Kisanuki YY, Bursell S, Yanagisawa M, King GL, Kahn CR. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest. 2003 May; 111(9):1373-80.
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  73. Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK, Bornfeldt KE, King GL. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 2003 Mar; 52(3):838-45.
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  74. Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37.
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  75. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Diabetic retinopathy. Diabetes Care. 2003 Jan; 26(1):226-9.
    View in: PubMed
  76. Shen GX, Way KJ, Jacobs JR, King GL. Applications of inhibitors for protein kinase C and their isoforms. Methods Mol Biol. 2003; 233:397-422.
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  77. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Diabetic retinopathy. Diabetes Care. 2003 Jan; 26 Suppl 1:S99-S102.
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  78. Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2003 Feb 28; 278(9):6976-84.
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  79. Sheetz MJ, King GL. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA. 2002 Nov 27; 288(20):2579-88.
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  80. Way KJ, Isshiki K, Suzuma K, Yokota T, Zvagelsky D, Schoen FJ, Sandusky GE, Pechous PA, Vlahos CJ, Wakasaki H, King GL. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes. 2002 Sep; 51(9):2709-18.
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  81. Hiramatsu Y, Sekiguchi N, Hayashi M, Isshiki K, Yokota T, King GL, Loeken MR. Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. Diabetes. 2002 Sep; 51(9):2804-10.
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  82. Mathis D, King GL. B-cell signaling: protein kinase Cdelta puts the brakes on. Curr Biol. 2002 Aug 20; 12(16):R554-6.
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  83. Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes. Circulation. 2002 May 7; 105(18):e138-43.
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  84. Rauniyar RK, Suzuma K, King AL, Aiello LP, King GL. Differential effects of bactericidal/permeability-increasing protein (BPI) analogues on retinal neovascularization and retinal pericyte growth. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):503-9.
    View in: PubMed
  85. Suzuma K, Takahara N, Suzuma I, Isshiki K, Ueki K, Leitges M, Aiello LP, King GL. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):721-6.
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  86. Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K, Suzuma K, Bowling NL, Vlahos CJ, Aiello LP, King GL. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 2002 Jan 22; 105(3):373-9.
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  87. Kaneto H, Suzuma K, Sharma A, Bonner-Weir S, King GL, Weir GC. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 1; 277(5):3680-5.
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  88. Suzuma I, Suzuma K, Ueki K, Hata Y, Feener EP, King GL, Aiello LP. Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways. J Biol Chem. 2002 Jan 11; 277(2):1047-57.
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  89. Smith FE, Chiu JL, King GL. Diabetes Mellitus and its Complications in Asian Americans. Asian Am Pac Isl J Health. 1999; 7(2):170-175.
    View in: PubMed
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