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Last Name
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Michael Goitein, PH.D.

TitleProfessor of Radiation Oncology (Radiation Biophysics), Emeritus
InstitutionMassachusetts General Hospital
DepartmentEmeritus
AddressMassachusetts General Hospital
Northeast Proton Therapy Ctr
55 Fruit St
Boston MA 02114
Phone617/724-9529
Fax617/726-9532

 Biography 
 awards and honors
1992 - Honorary member
2000 - Fellow
2003 - Gold Medal
2006 - Fellow (FASTRO)
2006 - Honorary member

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zietman A, Goitein M, Tepper JE. Technology evolution: is it survival of the fittest? J Clin Oncol. 2010 Sep 20; 28(27):4275-9.
    View in: PubMed
  2. Goitein M. Comment on Drs. Withers and Peters' letter concerning the editorial "magical protons?". Int J Radiat Oncol Biol Phys. 2010 Mar 1; 76(3):957-8; author reply 958.
    View in: PubMed
  3. Goitein M. How best to dispose of extra-tumoral dose: a cautionary note for intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2009 Sep 1; 75(1):1-3.
    View in: PubMed
  4. Goitein M. Trials and tribulations in charged particle radiotherapy. Radiother Oncol. 2010 Apr; 95(1):23-31.
    View in: PubMed
  5. Paganetti H, Goitein M, Parodi K. Spread-out antiproton beams deliver poor physical dose distributions for radiation therapy. Radiother Oncol. 2010 Apr; 95(1):79-86.
    View in: PubMed
  6. Goitein M. Magical protons? Int J Radiat Oncol Biol Phys. 2008 Mar 1; 70(3):654-6.
    View in: PubMed
  7. Goitein M, Cox JD. Should randomized clinical trials be required for proton radiotherapy? J Clin Oncol. 2008 Jan 10; 26(2):175-6.
    View in: PubMed
  8. Suit H, Goldberg S, Niemierko A, Ancukiewicz M, Hall E, Goitein M, Wong W, Paganetti H. Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects. Radiat Res. 2007 Jan; 167(1):12-42.
    View in: PubMed
  9. Zambarakji HJ, Lane AM, Ezra E, Gauthier D, Goitein M, Adams JA, Munzenrider JE, Miller JW, Gragoudas ES. Proton beam irradiation for neovascular age-related macular degeneration. Ophthalmology. 2006 Nov; 113(11):2012-9.
    View in: PubMed
  10. Goitein M. The cell's-eye view: assessing dose in four dimensions. Int J Radiat Oncol Biol Phys. 2005 Jul 15; 62(4):951-3.
    View in: PubMed
  11. Goitein M. Organ and tumor motion: an overview. Semin Radiat Oncol. 2004 Jan; 14(1):2-9.
    View in: PubMed
  12. Goitein M, Jermann M. The relative costs of proton and X-ray radiation therapy. Clin Oncol (R Coll Radiol). 2003 Feb; 15(1):S37-50.
    View in: PubMed
  13. Lomax AJ, Goitein M, Adams J. Intensity modulation in radiotherapy: photons versus protons in the paranasal sinus. Radiother Oncol. 2003 Jan; 66(1):11-8.
    View in: PubMed
  14. Gragoudas E, Li W, Goitein M, Lane AM, Munzenrider JE, Egan KM. Evidence-based estimates of outcome in patients irradiated for intraocular melanoma. Arch Ophthalmol. 2002 Dec; 120(12):1665-71.
    View in: PubMed
  15. Bortfeld T, Jokivarsi K, Goitein M, Kung J, Jiang SB. Effects of intra-fraction motion on IMRT dose delivery: statistical analysis and simulation. Phys Med Biol. 2002 Jul 7; 47(13):2203-20.
    View in: PubMed
  16. Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS, Suit HD. Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys. 2002 Jun 1; 53(2):407-21.
    View in: PubMed
  17. Paganetti H, Goitein M. Biophysical modelling of proton radiation effects based on amorphous track models. Int J Radiat Biol. 2001 Sep; 77(9):911-28.
    View in: PubMed
  18. Stavreva N, Niemierko A, Stavrev P, Goitein M. Modelling the dose-volume response of the spinal cord, based on the idea of damage to contiguous functional subunits. Int J Radiat Biol. 2001 Jun; 77(6):695-702.
    View in: PubMed
  19. Stavrev P, Stavreva N, Niemierko A, Goitein M. Generalization of a model of tissue response to radiation based on the idea of functional subunits and binomial statistics. Phys Med Biol. 2001 May; 46(5):1501-18.
    View in: PubMed
  20. Paganetti H, Gerweck LE, Goitein M. The general relation between tissue response to x-radiation (alpha/beta-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track-structure model. Int J Radiat Biol. 2000 Jul; 76(7):985-98.
    View in: PubMed
  21. Paganetti H, Goitein M. Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak. Med Phys. 2000 May; 27(5):1119-26.
    View in: PubMed
  22. Barkhof J, Schut G, Flanz JB, Goitein M, Schippers JM. Verification of the alignment of a therapeutic radiation beam relative to its patient positioner. Med Phys. 1999 Nov; 26(11):2429-37.
    View in: PubMed
  23. Terahara A, Niemierko A, Goitein M, Finkelstein D, Hug E, Liebsch N, O'Farrell D, Lyons S, Munzenrider J. Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma. Int J Radiat Oncol Biol Phys. 1999 Sep 1; 45(2):351-8.
    View in: PubMed
  24. Santoni R, Liebsch N, Finkelstein DM, Hug E, Hanssens P, Goitein M, Smith AR, O'Farrell D, Efird JT, Fullerton B, Munzenrider JE. Temporal lobe (TL) damage following surgery and high-dose photon and proton irradiation in 96 patients affected by chordomas and chondrosarcomas of the base of the skull. Int J Radiat Oncol Biol Phys. 1998 Apr 1; 41(1):59-68.
    View in: PubMed
  25. Hong L, Goitein M, Bucciolini M, Comiskey R, Gottschalk B, Rosenthal S, Serago C, Urie M. A pencil beam algorithm for proton dose calculations. Phys Med Biol. 1996 Aug; 41(8):1305-30.
    View in: PubMed
  26. Niemierko A, Goitein M. Dose-volume distributions: a new approach to dose-volume histograms in three-dimensional treatment planning. Med Phys. 1994 Jan; 21(1):3-11.
    View in: PubMed
  27. Niemierko A, Goitein M. Implementation of a model for estimating tumor control probability for an inhomogeneously irradiated tumor. Radiother Oncol. 1993 Nov; 29(2):140-7.
    View in: PubMed
  28. Benk VA, Adams JA, Shipley WU, Urie MM, McManus PL, Efird JT, Willett CG, Goitein M. Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma. Int J Radiat Oncol Biol Phys. 1993 Jun 15; 26(3):551-7.
    View in: PubMed
  29. Niemierko A, Goitein M. Modeling of normal tissue response to radiation: the critical volume model. Int J Radiat Oncol Biol Phys. 1993 Jan; 25(1):135-45.
    View in: PubMed
  30. Goitein M. The Comparison of Treatment Plans. Semin Radiat Oncol. 1992 Oct; 2(4):246-256.
    View in: PubMed
  31. Niemierko A, Urie M, Goitein M. Optimization of 3D radiation therapy with both physical and biological end points and constraints. Int J Radiat Oncol Biol Phys. 1992; 23(1):99-108.
    View in: PubMed
  32. Urie MM, Fullerton B, Tatsuzaki H, Birnbaum S, Suit HD, Convery K, Skates S, Goitein M. A dose response analysis of injury to cranial nerves and/or nuclei following proton beam radiation therapy. Int J Radiat Oncol Biol Phys. 1992; 23(1):27-39.
    View in: PubMed
  33. Goitein M. 3D treatment planning for heavy charged particles. Radiat Environ Biophys. 1992; 31(3):241-5.
    View in: PubMed
  34. Munzenrider JE, Doppke KP, Brown AP, Burman C, Cheng E, Chu J, Chui C, Drzymala RE, Goitein M, Manolis JM, et al. Three-dimensional treatment planning for para-aortic node irradiation in patients with cervical cancer. Int J Radiat Oncol Biol Phys. 1991 May 15; 21(1):229-42.
    View in: PubMed
  35. Urie MM, Goitein M, Doppke K, Kutcher JG, LoSasso T, Mohan R, Munzenrider JE, Sontag M, Wong JW. The role of uncertainty analysis in treatment planning. Int J Radiat Oncol Biol Phys. 1991 May 15; 21(1):91-107.
    View in: PubMed
  36. Niemierko A, Goitein M. Calculation of normal tissue complication probability and dose-volume histogram reduction schemes for tissues with a critical element architecture. Radiother Oncol. 1991 Mar; 20(3):166-76.
    View in: PubMed
  37. Niemierko A, Goitein M. Random sampling for evaluating treatment plans. Med Phys. 1990 Sep-Oct; 17(5):753-62.
    View in: PubMed
  38. Goitein M. Waiting patiently. N Engl J Med. 1990 Aug 30; 323(9):604-8.
    View in: PubMed
  39. Austin-Seymour M, Munzenrider J, Linggood R, Goitein M, Verhey L, Urie M, Gentry R, Birnbaum S, Ruotolo D, Crowell C, et al. Fractionated proton radiation therapy of cranial and intracranial tumors. Am J Clin Oncol. 1990 Aug; 13(4):327-30.
    View in: PubMed
  40. Suit HD, Goitein M, Munzenrider J, Verhey L, Urie M, Gragoudas E, Koehler A, Gottschalk B, Sisterson J, Tatsuzaki H, et al. Increased efficacy of radiation therapy by use of proton beam. Strahlenther Onkol. 1990 Jan; 166(1):40-4.
    View in: PubMed
  41. Austin-Seymour M, Urie M, Munzenrider J, Willett C, Goitein M, Verhey L, Gentry R, McNulty P, Koehler A, Suit H. Considerations in fractionated proton radiation therapy: clinical potential and results. Radiother Oncol. 1990 Jan; 17(1):29-35.
    View in: PubMed
  42. Stracher MA, Goitein M, Rowell D. Evaluation of volumetric differences through 3-dimensional display of distance of closest approach. Int J Radiat Oncol Biol Phys. 1989 Nov; 17(5):1095-8.
    View in: PubMed
  43. Sisterson JM, Urie MM, Koehler AM, Goitein M. Distal penetration of proton beams: the effects of air gaps between compensating bolus and patient. Phys Med Biol. 1989 Sep; 34(9):1309-15.
    View in: PubMed
  44. Egan KM, Gragoudas ES, Seddon JM, Glynn RJ, Munzenreider JE, Goitein M, Verhey L, Urie M, Koehler A. The risk of enucleation after proton beam irradiation of uveal melanoma. Ophthalmology. 1989 Sep; 96(9):1377-82; discussion 1382-3.
    View in: PubMed
  45. Urie MM, Goitein M. Variable versus fixed modulation of proton beams for treatments in the cranium. Med Phys. 1989 Jul-Aug; 16(4):593-601.
    View in: PubMed
  46. Habrand IL, Austin-Seymour M, Birnbaum S, Wray S, Carroll R, Munzenrider J, Verhey L, Urie M, Goitein M. Neurovisual outcome following proton radiation therapy. Int J Radiat Oncol Biol Phys. 1989 Jun; 16(6):1601-6.
    View in: PubMed
  47. Austin-Seymour M, Munzenrider J, Goitein M, Verhey L, Urie M, Gentry R, Birnbaum S, Ruotolo D, McManus P, Skates S, et al. Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull. J Neurosurg. 1989 Jan; 70(1):13-7.
    View in: PubMed
  48. Munzenrider JE, Gragoudas ES, Seddon JM, Sisterson J, McNulty P, Birnbaum S, Johnson K, Austin-Seymour M, Slater J, Goitein MM, et al. Conservative treatment of uveal melanoma: probability of eye retention after proton treatment. Int J Radiat Oncol Biol Phys. 1988 Sep; 15(3):553-8.
    View in: PubMed
  49. Slater JD, Austin-Seymour M, Munzenrider J, Birnbaum S, Carroll R, Klibanski A, Riskind P, Urie M, Verhey L, Goitein M. Endocrine function following high dose proton therapy for tumors of the upper clivus. Int J Radiat Oncol Biol Phys. 1988 Sep; 15(3):607-11.
    View in: PubMed
  50. Gragoudas ES, Seddon JM, Egan KM, Glynn RJ, Goitein M, Munzenrider J, Verhey L, Urie M, Koehler A. Metastasis from uveal melanoma after proton beam irradiation. Ophthalmology. 1988 Jul; 95(7):992-9.
    View in: PubMed
  51. Suit HD, Becht J, Leong J, Stracher M, Wood WC, Verhey L, Goitein M. Potential for improvement in radiation therapy. Int J Radiat Oncol Biol Phys. 1988 Apr; 14(4):777-86.
    View in: PubMed
  52. Doppke KP, Goitein M. A survey of the information gained from planning treatment with a computer. Med Phys. 1988 Mar-Apr; 15(2):258-62.
    View in: PubMed
  53. Suit HD, Goitein M, Munzenrider J, Verhey L, Davis KR, Koehler A, Linggood R, Ojemann RG. Definitive radiation therapy for chordoma and chondrosarcoma of base of skull and cervical spine. J Neurosurg. 1982 Mar; 56(3):377-85.
    View in: PubMed
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