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Rulla May Tamimi, S.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Channing Division of Network Medicine, 3rd Floor
181 Longwood Ave
Boston MA 02115
Phone617/525-0862
Fax617/525-2008
Other Positions
TitleAssociate Professor in the Department of Epidemiology
InstitutionHarvard School of Public Health
DepartmentEpidemiology


 Overview 
 overview
My goal is to better understand breast cancer risk and prognosis by utilizing molecular markers in epidemiologic studies. Specifically, my research has focused on intermediate markers of breast cancer risk including mammographic density and benign breast diseases (BBD). Many of these studies are based within the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII).

Mammographic Density Studies
Mammographic density is one of the strongest risk factors for breast cancer, yet the mechanisms underlying this are not well elucidated. I have multiple grants to examine lifestyle, genetic, and molecular predictors of mammographic density. We demonstrated for the first time that circulating hormones and mammographic density were independent predictors of breast cancer risk, and that women with high levels of both were at a particularly high risk of subsequent breast cancer in the NHS. These data suggest that incorporating both hormones and mammographic density into risk prediction models may identify high risk women for targeted interventions.

Mammographic density is a highly heritable trait, more so than breast cancer. Given the high heritability of mammographic density, understanding the genetic predictors of breast density may help to identify novel genes and pathways related to breast density and breast cancer. To better identify genetic predictors of mammographic density, I lead the Markers of Density (MODE) consortium, an international consortium to pool genome-wide association studies of mammographic density.

I have also leveraged randomized control trials, to study the effects of specific interventions on change in breast density. We have an ancillary breast health study within the Kronos Early Estrogen Prevention Study (KEEPS) randomized control trial to evaluate the effect of newer low-dose hormone therapies on breast density. Similarly, we have just been funded to conduct an ancillary study within the VITamin D and omega-3 trial (VITAL), to study association between vitamin D supplementation on breast density and breast tissue molecular and morphologic features.

Additionally, I have initiated a multi-ethnic pilot study of mammographic density enrolling women coming in for routine screening mammograms at the Lee Bell Center for Breast Imaging at Brigham and Women’s Hospital.

Benign Breast Disease Studies
Benign breast diseases are also thought of as general markers of breast cancer risk. Within the Nurses’ Health Studies my group has examined exposures associated with early proliferative changes in the breast, and how morphologic and molecular changes in benign breast tissue are related to subsequent risk of breast cancer. Recently, we found that early adolescent exposures influence later proliferative breast disease risk. Although it had been hypothesized that adolescence may be an important time period for breast cancer, these projects are critical for identifying the modifiable exposures that may influence long-term breast health. Most recently, we have identified molecular alterations in benign breast tissue that predict long-term risk of subsequent breast cancer. These projects have important public health implications for identifying early opportunities for cancer prevention.

Breast Cancer
Breast cancer is a heterogeneous disease. Characterization of breast tumors by hormone receptor status has been important in understanding the mechanisms by which certain breast cancer risk factors operate, but also for determining treatment and prognosis. I have worked closely with collaborating pathologists to create breast cancer tissue microarrays within the Nurses’ Health Study. This will allow us to examine how lifestyle factors, and genetic and plasma markers influence the molecular characteristics of the breast tumor. Better molecular classification of breast tumors may provide important clues as to the biology and underlying mechanisms of breast carcinogenesis. My long-term goals are to incorporate the full spectrum of resources including genetic variation, early life exposures, circulating markers, tissue markers and intermediate endpoints to fully develop and address hypotheses about breast cancer risk.

In addition to my research interests, I have enjoyed a number of local teaching and mentoring opportunities at the Harvard School of Public Health, and Harvard Medical School.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ruddy KJ, Gelber S, Tamimi RM, Schapira L, Come SE, Meyer ME, Winer EP, Partridge AH. Breast cancer presentation and diagnostic delays in young women. Cancer. 2014 Jan 1; 120(1):20-5.
    View in: PubMed
  2. Warner ET, Colditz GA, Palmer JR, Partridge AH, Rosner BA, Tamimi RM. Reproductive factors and risk of premenopausal breast cancer by age at diagnosis: Are there differences before and after age 40? Breast Cancer Res Treat. 2013 Nov; 142(1):165-75.
    View in: PubMed
  3. Ahern TP, Hankinson SE, Willett WC, Pollak MN, Eliassen AH, Tamimi RM. Plasma C-Peptide, mammographic breast density, and risk of invasive breast cancer. Cancer Epidemiol Biomarkers Prev. 2013 Oct; 22(10):1786-96.
    View in: PubMed
  4. Berkey CS, Willett WC, Tamimi RM, Rosner B, Frazier AL, Colditz GA. Vegetable protein and vegetable fat intakes in pre-adolescent and adolescent girls, and risk for benign breast disease in young women. Breast Cancer Res Treat. 2013 Sep; 141(2):299-306.
    View in: PubMed
  5. Liu Y, Colditz GA, Rosner B, Berkey CS, Collins LC, Schnitt SJ, Connolly JL, Chen WY, Willett WC, Tamimi RM. Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk. J Natl Cancer Inst. 2013 Oct 16; 105(20):1571-8.
    View in: PubMed
  6. Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, Ericson U, Koivula RW, Chu AY, Rose LM, Ganna A, Qi Q, Stancáková A, Sandholt CH, Elks CE, Curhan G, Jensen MK, Tamimi RM, Allin KH, Jørgensen T, Brage S, Langenberg C, Aadahl M, Grarup N, Linneberg A, Paré G, Magnusson PK, Pedersen NL, Boehnke M, Hamsten A, Mohlke KL, Pasquale LT, Pedersen O, Scott RA, Ridker PM, Ingelsson E, Laakso M, Hansen T, Qi L, Wareham NJ, Chasman DI, Hallmans G, Hu FB, Renström F, Orho-Melander M, Franks PW. Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet. 2013 Jul; 9(7):e1003607.
    View in: PubMed
  7. Choudhury S, Almendro V, Merino VF, Wu Z, Maruyama R, Su Y, Martins FC, Fackler MJ, Bessarabova M, Kowalczyk A, Conway T, Beresford-Smith B, Macintyre G, Cheng YK, Lopez-Bujanda Z, Kaspi A, Hu R, Robens J, Nikolskaya T, Haakensen VD, Schnitt SJ, Argani P, Ethington G, Panos L, Grant M, Clark J, Herlihy W, Lin SJ, Chew G, Thompson EW, Greene-Colozzi A, Richardson AL, Rosson GD, Pike M, Garber JE, Nikolsky Y, Blum JL, Au A, Hwang ES, Tamimi RM, Michor F, Haviv I, Liu XS, Sukumar S, Polyak K. Molecular Profiling of Human Mammary Gland Links Breast Cancer Risk to a p27(+) Cell Population with Progenitor Characteristics. Cell Stem Cell. 2013 Jul 3; 13(1):117-30.
    View in: PubMed
  8. Rice MS, Biessy C, Lajous M, Bertrand KA, Tamimi RM, Torres-Mejía G, López-Ridaura R, Romieu I. Metabolic syndrome and mammographic density in mexican women. Cancer Prev Res (Phila). 2013 Jul; 6(7):701-10.
    View in: PubMed
  9. Rosner B, Glynn RJ, Tamimi RM, Chen WY, Colditz GA, Willett WC, Hankinson SE. Breast cancer risk prediction with heterogeneous risk profiles according to breast cancer tumor markers. Am J Epidemiol. 2013 Jul 15; 178(2):296-308.
    View in: PubMed
  10. Aroner SA, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Rosner BA, Hankinson SE, Tamimi RM. Radial scars and subsequent breast cancer risk: results from the Nurses' Health Studies. Breast Cancer Res Treat. 2013 May; 139(1):277-85.
    View in: PubMed
  11. Yaghjyan L, Colditz GA, Rosner B, Tamimi RM. Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to the time since the mammogram. Cancer Epidemiol Biomarkers Prev. 2013 Jun; 22(6):1110-7.
    View in: PubMed
  12. Berkey CS, Willett WC, Tamimi RM, Rosner B, Frazier AL, Colditz GA. Dairy intakes in older girls and risk of benign breast disease in young women. Cancer Epidemiol Biomarkers Prev. 2013 Apr; 22(4):670-4.
    View in: PubMed
  13. Aschard H, Zaitlen N, Tamimi RM, Lindström S, Kraft P. A nonparametric test to detect quantitative trait Loci where the phenotypic distribution differs by genotypes. Genet Epidemiol. 2013 May; 37(4):323-33.
    View in: PubMed
  14. Rice MS, Bertrand KA, Lajous M, Tamimi RM, Torres-Mejía G, Biessy C, López-Ridaura R, Romieu I. Body size throughout the life course and mammographic density in Mexican women. Breast Cancer Res Treat. 2013 Apr; 138(2):601-10.
    View in: PubMed
  15. Warner ET, Tamimi RM, Boggs DA, Rosner B, Rosenberg L, Colditz GA, Palmer JR. Estrogen receptor positive tumors: Do reproductive factors explain differences in incidence between black and white women? Cancer Causes Control. 2013 Apr; 24(4):731-9.
    View in: PubMed
  16. Eliassen AH, Hendrickson SJ, Brinton LA, Buring JE, Campos H, Dai Q, Dorgan JF, Franke AA, Gao YT, Goodman MT, Hallmans G, Helzlsouer KJ, Hoffman-Bolton J, Hultén K, Sesso HD, Sowell AL, Tamimi RM, Toniolo P, Wilkens LR, Winkvist A, Zeleniuch-Jacquotte A, Zheng W, Hankinson SE. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. J Natl Cancer Inst. 2012 Dec 19; 104(24):1905-16.
    View in: PubMed
  17. Kalager M, Tamimi RM, Bretthauer M, Adami HO. Prognosis in women with interval breast cancer: population based observational cohort study. BMJ. 2012; 345:e7536.
    View in: PubMed
  18. Winter AC, Rexrode KM, Lee IM, Buring JE, Tamimi RM, Kurth T. Migraine and subsequent risk of breast cancer: a prospective cohort study. Cancer Causes Control. 2013 Jan; 24(1):81-9.
    View in: PubMed
  19. Rosenberg SM, Tamimi RM, Gelber S, Ruddy KJ, Kereakoglow S, Borges VF, Come SE, Schapira L, Winer EP, Partridge AH. Body image in recently diagnosed young women with early breast cancer. Psychooncology. 2013 Aug; 22(8):1849-55.
    View in: PubMed
  20. Warner ET, Tamimi RM, Hughes ME, Ottesen RA, Wong YN, Edge SB, Theriault RL, Blayney DW, Niland JC, Winer EP, Weeks JC, Partridge AH. Time to diagnosis and breast cancer stage by race/ethnicity. Breast Cancer Res Treat. 2012 Dec; 136(3):813-21.
    View in: PubMed
  21. Rice MS, Tworoger SS, Rosner BA, Pollak MN, Hankinson SE, Tamimi RM. Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, growth hormone, and mammographic density in the Nurses' Health Studies. Breast Cancer Res Treat. 2012 Dec; 136(3):805-12.
    View in: PubMed
  22. Massa J, Hamdan A, Simon KC, Bertrand K, Wulf G, Tamimi RM, Ascherio A. Infectious mononucleosis and risk of breast cancer in a prospective study of women. Cancer Causes Control. 2012 Dec; 23(12):1893-8.
    View in: PubMed
  23. Bertrand KA, Eliassen AH, Hankinson SE, Gierach GL, Xu X, Rosner B, Ziegler RG, Tamimi RM. Urinary estrogens and estrogen metabolites and mammographic density in premenopausal women. Breast Cancer Res Treat. 2012 Nov; 136(1):277-87.
    View in: PubMed
  24. Kalager M, Adami HO, Bretthauer M, Tamimi RM. Overdiagnosis of Invasive Breast Cancer due to Mammography Screening. Ann Intern Med. 2012 Aug 7; 157(3):221-2.
    View in: PubMed
  25. Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell. 2012 Aug 3; 150(3):549-62.
    View in: PubMed
  26. Pettersson A, Tamimi RM. Breast fat and breast cancer. Breast Cancer Res Treat. 2012 Aug; 135(1):321-3.
    View in: PubMed
  27. Su X, Colditz GA, Collins LC, Baer HJ, Sampson LA, Willett WC, Berkey CS, Schnitt SJ, Connolly JL, Rosner BA, Tamimi RM. Adolescent intakes of vitamin D and calcium and incidence of proliferative benign breast disease. Breast Cancer Res Treat. 2012 Jul; 134(2):783-91.
    View in: PubMed
  28. Partridge AH, Hughes ME, Ottesen RA, Wong YN, Edge SB, Theriault RL, Blayney DW, Niland JC, Winer EP, Weeks JC, Tamimi RM. The effect of age on delay in diagnosis and stage of breast cancer. Oncologist. 2012; 17(6):775-82.
    View in: PubMed
  29. Stevens KN, Lindstrom S, Scott CG, Thompson D, Sellers TA, Wang X, Wang A, Atkinson E, Rider DN, Eckel-Passow JE, Varghese JS, Audley T, Brown J, Leyland J, Luben RN, Warren RM, Loos RJ, Wareham NJ, Li J, Hall P, Liu J, Eriksson L, Czene K, Olson JE, Pankratz VS, Fredericksen Z, Diasio RB, Lee AM, Heit JA, DeAndrade M, Goode EL, Vierkant RA, Cunningham JM, Armasu SM, Weinshilboum R, Fridley BL, Batzler A, Ingle JN, Boyd NF, Paterson AD, Rommens J, Martin LJ, Hopper JL, Southey MC, Stone J, Apicella C, Kraft P, Hankinson SE, Hazra A, Hunter DJ, Easton DF, Couch FJ, Tamimi RM, Vachon CM. Identification of a novel percent mammographic density locus at 12q24. Hum Mol Genet. 2012 Jul 15; 21(14):3299-305.
    View in: PubMed
  30. Shui IM, Mucci LA, Kraft P, Tamimi RM, Lindstrom S, Penney KL, Nimptsch K, Hollis BW, Dupre N, Platz EA, Stampfer MJ, Giovannucci E. Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study. J Natl Cancer Inst. 2012 May 2; 104(9):690-9.
    View in: PubMed
  31. Liu Y, Tamimi RM, Berkey CS, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Colditz GA. Intakes of alcohol and folate during adolescence and risk of proliferative benign breast disease. Pediatrics. 2012 May; 129(5):e1192-8.
    View in: PubMed
  32. Kalager M, Adami HO, Bretthauer M, Tamimi RM. Overdiagnosis of invasive breast cancer due to mammography screening: results from the Norwegian screening program. Ann Intern Med. 2012 Apr 3; 156(7):491-9.
    View in: PubMed
  33. Vachon CM, Scott CG, Fasching PA, Hall P, Tamimi RM, Li J, Stone J, Apicella C, Odefrey F, Gierach GL, Jud SM, Heusinger K, Beckmann MW, Pollan M, Fernández-Navarro P, Gonzalez-Neira A, Benitez J, van Gils CH, Lokate M, Onland-Moret NC, Peeters PH, Brown J, Leyland J, Varghese JS, Easton DF, Thompson DJ, Luben RN, Warren RM, Wareham NJ, Loos RJ, Khaw KT, Ursin G, Lee E, Gayther SA, Ramus SJ, Eeles RA, Leach MO, Kwan-Lim G, Couch FJ, Giles GG, Baglietto L, Krishnan K, Southey MC, Le Marchand L, Kolonel LN, Woolcott C, Maskarinec G, Haiman CA, Walker K, Johnson N, McCormack VA, Biong M, Alnaes GI, Gram IT, Kristensen VN, Børresen-Dale AL, Lindström S, Hankinson SE, Hunter DJ, Andrulis IL, Knight JA, Boyd NF, Figuero JD, Lissowska J, Wesolowska E, Peplonska B, Bukowska A, Reszka E, Liu J, Eriksson L, Czene K, Audley T, Wu AH, Pankratz VS, Hopper JL, dos-Santos-Silva I. Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2012 Jul; 21(7):1156-66.
    View in: PubMed
  34. Yaghjyan L, Colditz GA, Rosner B, Tamimi RM. Mammographic breast density and breast cancer risk by menopausal status, postmenopausal hormone use and a family history of breast cancer. Cancer Causes Control. 2012 May; 23(5):785-90.
    View in: PubMed
  35. Rice MS, Tamimi RM, Connolly JL, Collins LC, Shen D, Pollak MN, Rosner B, Hankinson SE, Tworoger SS. Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II. Breast Cancer Res. 2012; 14(2):R44.
    View in: PubMed
  36. Varghese JS, Thompson DJ, Michailidou K, Lindström S, Turnbull C, Brown J, Leyland J, Warren RM, Luben RN, Loos RJ, Wareham NJ, Rommens J, Paterson AD, Martin LJ, Vachon CM, Scott CG, Atkinson EJ, Couch FJ, Apicella C, Southey MC, Stone J, Li J, Eriksson L, Czene K, Boyd NF, Hall P, Hopper JL, Tamimi RM, Rahman N, Easton DF. Mammographic breast density and breast cancer: evidence of a shared genetic basis. Cancer Res. 2012 Mar 15; 72(6):1478-84.
    View in: PubMed
  37. Bertone-Johnson ER, McTiernan A, Thomson CA, Wactawski-Wende J, Aragaki AK, Rohan TE, Vitolins MZ, Tamimi RM, Johnson KC, Lane D, Rexrode KM, Peck JD, Chlebowski RT, Sarto G, Manson JE. Vitamin D and calcium supplementation and one-year change in mammographic density in the women's health initiative calcium and vitamin D trial. Cancer Epidemiol Biomarkers Prev. 2012 Mar; 21(3):462-73.
    View in: PubMed
  38. Berkey CS, Tamimi RM, Rosner B, Frazier AL, Colditz GA. Young women with family history of breast cancer and their risk factors for benign breast disease. Cancer. 2012 Jun 1; 118(11):2796-803.
    View in: PubMed
  39. Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA. High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A. 2011 Nov 8; 108(45):18378-83.
    View in: PubMed
  40. Pettersson A, Hankinson SE, Willett WC, Lagiou P, Trichopoulos D, Tamimi RM. Nondense mammographic area and risk of breast cancer. Breast Cancer Res. 2011; 13(5):R100.
    View in: PubMed
  41. Harris HR, Tamimi RM, Willett WC, Hankinson SE, Michels KB. Body size across the life course, mammographic density, and risk of breast cancer. Am J Epidemiol. 2011 Oct 15; 174(8):909-18.
    View in: PubMed
  42. Tamimi RM, Colditz GA, Hazra A, Baer HJ, Hankinson SE, Rosner B, Marotti J, Connolly JL, Schnitt SJ, Collins LC. Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer. Breast Cancer Res Treat. 2012 Jan; 131(1):159-67.
    View in: PubMed
  43. Yaghjyan L, Colditz GA, Collins LC, Schnitt SJ, Rosner B, Vachon C, Tamimi RM. Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics. J Natl Cancer Inst. 2011 Aug 3; 103(15):1179-89.
    View in: PubMed
  44. Jung MM, Colditz GA, Collins LC, Schnitt SJ, Connolly JL, Tamimi RM. Lifetime physical activity and the incidence of proliferative benign breast disease. Cancer Causes Control. 2011 Sep; 22(9):1297-305.
    View in: PubMed
  45. Holmes MD, Chen WY, Schnitt SJ, Collins L, Colditz GA, Hankinson SE, Tamimi RM. COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin. Breast Cancer Res Treat. 2011 Nov; 130(2):657-62.
    View in: PubMed
  46. Shui IM, Stark JR, Penney KL, Schumacher FR, Epstein MM, Pitt MJ, Stampfer MJ, Tamimi RM, Lindstrom S, Sesso HD, Fall K, Ma J, Kraft P, Giovannucci E, Mucci LA. Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality. Prostate. 2012 Feb 1; 72(2):209-16.
    View in: PubMed
  47. Collins LC, Cole KS, Marotti JD, Hu R, Schnitt SJ, Tamimi RM. Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health Study. Mod Pathol. 2011 Jul; 24(7):924-31.
    View in: PubMed
  48. Liu Y, Tamimi RM, Collins LC, Schnitt SJ, Gilmore HL, Connolly JL, Colditz GA. The association between vascular endothelial growth factor expression in invasive breast cancer and survival varies with intrinsic subtypes and use of adjuvant systemic therapy: results from the Nurses' Health Study. Breast Cancer Res Treat. 2011 Aug; 129(1):175-84.
    View in: PubMed
  49. Berkey CS, Willett WC, Frazier AL, Rosner B, Tamimi RM, Colditz GA. Prospective study of growth and development in older girls and risk of benign breast disease in young women. Cancer. 2011 Apr 15; 117(8):1612-20.
    View in: PubMed
  50. Hu R, Dawood S, Holmes MD, Collins LC, Schnitt SJ, Cole K, Marotti JD, Hankinson SE, Colditz GA, Tamimi RM. Androgen receptor expression and breast cancer survival in postmenopausal women. Clin Cancer Res. 2011 Apr 1; 17(7):1867-74.
    View in: PubMed
  51. Lindström S, Vachon CM, Li J, Varghese J, Thompson D, Warren R, Brown J, Leyland J, Audley T, Wareham NJ, Loos RJ, Paterson AD, Rommens J, Waggott D, Martin LJ, Scott CG, Pankratz VS, Hankinson SE, Hazra A, Hunter DJ, Hopper JL, Southey MC, Chanock SJ, Silva Idos S, Liu J, Eriksson L, Couch FJ, Stone J, Apicella C, Czene K, Kraft P, Hall P, Easton DF, Boyd NF, Tamimi RM. Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nat Genet. 2011 Mar; 43(3):185-7.
    View in: PubMed
  52. Tamimi RM, Colditz GA, Wang Y, Collins LC, Hu R, Rosner B, Irie HY, Connolly JL, Schnitt SJ. Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer. Breast Cancer Res Treat. 2011 Jul; 128(1):243-50.
    View in: PubMed
  53. Yang XR, Chang-Claude J, Goode EL, Couch FJ, Nevanlinna H, Milne RL, Gaudet M, Schmidt MK, Broeks A, Cox A, Fasching PA, Hein R, Spurdle AB, Blows F, Driver K, Flesch-Janys D, Heinz J, Sinn P, Vrieling A, Heikkinen T, Aittomäki K, Heikkilä P, Blomqvist C, Lissowska J, Peplonska B, Chanock S, Figueroa J, Brinton L, Hall P, Czene K, Humphreys K, Darabi H, Liu J, Van 't Veer LJ, van Leeuwen FE, Andrulis IL, Glendon G, Knight JA, Mulligan AM, O'Malley FP, Weerasooriya N, John EM, Beckmann MW, Hartmann A, Weihbrecht SB, Wachter DL, Jud SM, Loehberg CR, Baglietto L, English DR, Giles GG, McLean CA, Severi G, Lambrechts D, Vandorpe T, Weltens C, Paridaens R, Smeets A, Neven P, Wildiers H, Wang X, Olson JE, Cafourek V, Fredericksen Z, Kosel M, Vachon C, Cramp HE, Connley D, Cross SS, Balasubramanian SP, Reed MW, Dörk T, Bremer M, Meyer A, Karstens JH, Ay A, Park-Simon TW, Hillemanns P, Arias Pérez JI, Menéndez Rodríguez P, Zamora P, Benítez J, Ko YD, Fischer HP, Hamann U, Pesch B, Brüning T, Justenhoven C, Brauch H, Eccles DM, Tapper WJ, Gerty SM, Sawyer EJ, Tomlinson IP, Jones A, Kerin M, Miller N, McInerney N, Anton-Culver H, Ziogas A, Shen CY, Hsiung CN, Wu PE, Yang SL, Yu JC, Chen ST, Hsu GC, Haiman CA, Henderson BE, Le Marchand L, Kolonel LN, Lindblom A, Margolin S, Jakubowska A, Lubinski J, Huzarski T, Byrski T, Górski B, Gronwald J, Hooning MJ, Hollestelle A, van den Ouweland AM, Jager A, Kriege M, Tilanus-Linthorst MM, Collée M, Wang-Gohrke S, Pylkäs K, Jukkola-Vuorinen A, Mononen K, Grip M, Hirvikoski P, Winqvist R, Mannermaa A, Kosma VM, Kauppinen J, Kataja V, Auvinen P, Soini Y, Sironen R, Bojesen SE, Ørsted DD, Kaur-Knudsen D, Flyger H, Nordestgaard BG, Holland H, Chenevix-Trench G, Manoukian S, Barile M, Radice P, Hankinson SE, Hunter DJ, Tamimi R, Sangrajrang S, Brennan P, McKay J, Odefrey F, Gaborieau V, Devilee P, Huijts PE, Tollenaar RA, Seynaeve C, Dite GS, Apicella C, Hopper JL, Hammet F, Tsimiklis H, Smith LD, Southey MC, Humphreys MK, Easton D, Pharoah P, Sherman ME, Garcia-Closas M. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst. 2011 Feb 2; 103(3):250-63.
    View in: PubMed
  54. Bertone-Johnson ER, Chlebowski RT, Manson JE, Wactawski-Wende J, Aragaki AK, Tamimi RM, Rexrode KM, Thomson CA, Rohan TE, Peck JD, Pisano ED, Martin CF, Sarto G, McTiernan A. Dietary vitamin D and calcium intake and mammographic density in postmenopausal women. Menopause. 2010 Nov-Dec; 17(6):1152-60.
    View in: PubMed
  55. Tamimi RM, Rosner B, Colditz GA. Evaluation of a breast cancer risk prediction model expanded to include category of prior benign breast disease lesion. Cancer. 2010 Nov 1; 116(21):4944-53.
    View in: PubMed
  56. Dawood S, Hu R, Homes MD, Collins LC, Schnitt SJ, Connolly J, Colditz GA, Tamimi RM. Defining breast cancer prognosis based on molecular phenotypes: results from a large cohort study. Breast Cancer Res Treat. 2011 Feb; 126(1):185-92.
    View in: PubMed
  57. Aroner SA, Collins LC, Schnitt SJ, Connolly JL, Colditz GA, Tamimi RM. Columnar cell lesions and subsequent breast cancer risk: a nested case-control study. Breast Cancer Res. 2010; 12(4):R61.
    View in: PubMed
  58. Green AK, Hankinson SE, Bertone-Johnson ER, Tamimi RM. Mammographic density, plasma vitamin D levels and risk of breast cancer in postmenopausal women. Int J Cancer. 2010 Aug 1; 127(3):667-74.
    View in: PubMed
  59. Berkey CS, Willett WC, Frazier AL, Rosner B, Tamimi RM, Rockett HR, Colditz GA. Prospective study of adolescent alcohol consumption and risk of benign breast disease in young women. Pediatrics. 2010 May; 125(5):e1081-7.
    View in: PubMed
  60. Su X, Tamimi RM, Collins LC, Baer HJ, Cho E, Sampson L, Willett WC, Schnitt SJ, Connolly JL, Rosner BA, Colditz GA. Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease. Cancer Causes Control. 2010 Jul; 21(7):1033-46.
    View in: PubMed
  61. Li J, Eriksson L, Humphreys K, Czene K, Liu J, Tamimi RM, Lindström S, Hunter DJ, Vachon CM, Couch FJ, Scott CG, Lagiou P, Hall P. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. Breast Cancer Res. 2010; 12(2):R19.
    View in: PubMed
  62. Tamimi RM, Eriksson L, Lagiou P, Czene K, Ekbom A, Hsieh CC, Adami HO, Trichopoulos D, Hall P. Birth weight and mammographic density among postmenopausal women in Sweden. Int J Cancer. 2010 Feb 15; 126(4):985-91.
    View in: PubMed
  63. Tamimi RM, Lagiou P, Czene K, Liu J, Ekbom A, Hsieh CC, Adami HO, Trichopoulos D, Hall P. Birth weight, breast cancer susceptibility loci, and breast cancer risk. Cancer Causes Control. 2010 May; 21(5):689-96.
    View in: PubMed
  64. Su X, Colditz GA, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Pollak MN, Rosner B, Tamimi RM. Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease. Int J Cancer. 2010 Jan 1; 126(1):180-90.
    View in: PubMed
  65. Tamimi RM, Colditz GA, Hankinson SE. Circulating carotenoids, mammographic density, and subsequent risk of breast cancer. Cancer Res. 2009 Dec 15; 69(24):9323-9.
    View in: PubMed
  66. Monsees GM, Tamimi RM, Kraft P. Genome-wide association scans for secondary traits using case-control samples. Genet Epidemiol. 2009 Dec; 33(8):717-28.
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  67. Marotti JD, Collins LC, Hu R, Tamimi RM. Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health Study. Mod Pathol. 2010 Feb; 23(2):197-204.
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  68. Collins LC, Wang Y, Connolly JL, Baer HJ, Hu R, Schnitt SJ, Colditz GA, Tamimi RM. Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissue. Appl Immunohistochem Mol Morphol. 2009 Oct; 17(5):438-41.
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  69. Baer HJ, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Tamimi RM. Lobule type and subsequent breast cancer risk: results from the Nurses' Health Studies. Cancer. 2009 Apr 1; 115(7):1404-11.
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  70. Birmann BM, Tamimi RM, Giovannucci E, Rosner B, Hunter DJ, Kraft P, Mitsiades C, Anderson KC, Colditz GA. Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):282-8.
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  71. Tamimi RM, Cox D, Kraft P, Colditz GA, Hankinson SE, Hunter DJ. Breast cancer susceptibility loci and mammographic density. Breast Cancer Res. 2008; 10(4):R66.
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  72. Tamimi RM, Baer HJ, Marotti J, Galan M, Galaburda L, Fu Y, Deitz AC, Connolly JL, Schnitt SJ, Colditz GA, Collins LC. Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancer. Breast Cancer Res. 2008; 10(4):R67.
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  73. Garcia-Closas M, Hall P, Nevanlinna H, Pooley K, Morrison J, Richesson DA, Bojesen SE, Nordestgaard BG, Axelsson CK, Arias JI, Milne RL, Ribas G, González-Neira A, Benítez J, Zamora P, Brauch H, Justenhoven C, Hamann U, Ko YD, Bruening T, Haas S, Dörk T, Schürmann P, Hillemanns P, Bogdanova N, Bremer M, Karstens JH, Fagerholm R, Aaltonen K, Aittomäki K, von Smitten K, Blomqvist C, Mannermaa A, Uusitupa M, Eskelinen M, Tengström M, Kosma VM, Kataja V, Chenevix-Trench G, Spurdle AB, Beesley J, Chen X, Devilee P, van Asperen CJ, Jacobi CE, Tollenaar RA, Huijts PE, Klijn JG, Chang-Claude J, Kropp S, Slanger T, Flesch-Janys D, Mutschelknauss E, Salazar R, Wang-Gohrke S, Couch F, Goode EL, Olson JE, Vachon C, Fredericksen ZS, Giles GG, Baglietto L, Severi G, Hopper JL, English DR, Southey MC, Haiman CA, Henderson BE, Kolonel LN, Le Marchand L, Stram DO, Hunter DJ, Hankinson SE, Cox DG, Tamimi R, Kraft P, Sherman ME, Chanock SJ, Lissowska J, Brinton LA, Peplonska B, Klijn JG, Hooning MJ, Meijers-Heijboer H, Collee JM, van den Ouweland A, Uitterlinden AG, Liu J, Lin LY, Yuqing L, Humphreys K, Czene K, Cox A, Balasubramanian SP, Cross SS, Reed MW, Blows F, Driver K, Dunning A, Tyrer J, Ponder BA, Sangrajrang S, Brennan P, McKay J, Odefrey F, Gabrieau V, Sigurdson A, Doody M, Struewing JP, Alexander B, Easton DF, Pharoah PD. Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet. 2008 Apr; 4(4):e1000054.
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  74. He C, Tamimi RM, Hankinson SE, Hunter DJ, Han J. A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk. Breast Cancer Res Treat. 2009 Feb; 113(3):585-94.
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  75. Collins LC, Marotti JD, Baer HJ, Tamimi RM. Comparison of estrogen receptor results from pathology reports with results from central laboratory testing. J Natl Cancer Inst. 2008 Feb 6; 100(3):218-21.
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  76. Tamimi RM, Brugge JS, Freedman ML, Miron A, Iglehart JD, Colditz GA, Hankinson SE. Circulating colony stimulating factor-1 and breast cancer risk. Cancer Res. 2008 Jan 1; 68(1):18-21.
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  77. Hankinson S, Tamimi R, Hunter D. Breast Cancer. Adami HO, Hunter D, Trichopoulos D (eds.)Textbook of Cancer Epidemiology. 2008.
  78. Richiardi L, Tamimi R, Adami HO. Testicular Cancer. Adami HO, Hunter D, Trichopoulos D (eds.)Textbook of Cancer Epidemiology. 2008.
  79. Tamimi RM, Byrne C, Colditz GA, Hankinson SE. Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 2007 Aug 1; 99(15):1178-87.
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  80. Samimi G, Colditz GA, Baer HJ, Tamimi RM. Measures of energy balance and mammographic density in the Nurses' Health Study. Breast Cancer Res Treat. 2008 May; 109(1):113-22.
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  81. Collins LC, Baer HJ, Tamimi RM, Connolly JL, Colditz GA, Schnitt SJ. Magnitude and laterality of breast cancer risk according to histologic type of atypical hyperplasia: results from the Nurses' Health Study. Cancer. 2007 Jan 15; 109(2):180-7.
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  82. Tamimi RM, Cox DG, Kraft P, Pollak MN, Haiman CA, Cheng I, Freedman ML, Hankinson SE, Hunter DJ, Colditz GA. Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study. Breast Cancer Res. 2007; 9(1):R18.
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  83. Collins LC, Baer HJ, Tamimi RM, Connolly JL, Colditz GA, Schnitt SJ. The influence of family history on breast cancer risk in women with biopsy-confirmed benign breast disease: results from the Nurses' Health Study. Cancer. 2006 Sep 15; 107(6):1240-7.
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  84. Cox DG, Tamimi RM, Hunter DJ. Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study. BMC Cancer. 2006; 6:217.
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  85. Tamimi RM, Hankinson SE, Chen WY, Rosner B, Colditz GA. Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med. 2006 Jul 24; 166(14):1483-9.
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  86. Colditz GA, Baer HJ, Tamimi RM. Epidemiology of Breast Cancer. Shottenfeld, Fraumeni (eds.). Cancer Epidemiology and Prevention. 2006; in press:995-1012.
  87. Tamimi RM. Single nucleotide polymorphisms and breast cancer: not yet a success story. Breast Cancer Res. 2006; 8(4):108.
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  88. Tamimi RM, Hankinson SE, Colditz GA, Byrne C. Endogenous sex hormone levels and mammographic density among postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2005 Nov; 14(11 Pt 1):2641-7.
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  89. Tamimi RM, Byrne C, Baer HJ, Rosner B, Schnitt SJ, Connolly JL, Colditz GA. Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case-control study. Breast Cancer Res. 2005; 7(4):R555-62.
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  90. Collins LC, Tamimi RM, Baer HJ, Connolly JL, Colditz GA, Schnitt SJ. Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses' Health Study. Cancer. 2005 May 1; 103(9):1778-84.
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  91. Tamimi RM, Hankinson SE, Campos H, Spiegelman D, Zhang S, Colditz GA, Willett WC, Hunter DJ. Plasma carotenoids, retinol, and tocopherols and risk of breast cancer. Am J Epidemiol. 2005 Jan 15; 161(2):153-60.
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  92. Holmberg L, Tamimi R. . Reducing cancer drug doses in obese patients: dogma disputed. Lancet. 2005; 366:1056-7.
  93. Mucci LA, Lagiou P, Hsieh CC, Tamimi R, Hellerstein S, Vatten L, Adami HO, Cnattingius S, Trichopoulos D. A prospective study of pregravid oral contraceptive use in relation to fetal growth. BJOG. 2004 Sep; 111(9):989-95.
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  94. Tamimi RM, Hankinson SE, Spiegelman D, Kraft P, Colditz GA, Hunter DJ. Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study. Breast Cancer Res. 2004; 6(4):R416-22.
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  95. Tamimi RM, Hankinson SE, Spiegelman D, Colditz GA, Hunter DJ. Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2004 Jun; 13(6):989-96.
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  96. Lagiou P, Mucci L, Tamimi R, Kuper H, Lagiou A, Hsieh CC, Trichopoulos D. Micronutrient intake during pregnancy in relation to birth size. Eur J Nutr. 2005 Feb; 44(1):52-9.
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  97. Lagiou P, Tamimi RM, Mucci LA, Adami HO, Hsieh CC, Trichopoulos D. Diet during pregnancy in relation to maternal weight gain and birth size. Eur J Clin Nutr. 2004 Feb; 58(2):231-7.
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  98. Tamimi RM, Hankinson SE, Ding S, Gagalang V, Larson GP, Spiegelman D, Colditz GA, Krontiris TG, Hunter DJ. The HRAS1 variable number of tandem repeats and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2003 Dec; 12(12):1528-30.
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  99. Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Res. 2003 Dec 1; 63(23):8536-41.
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  100. Tamimi R, Lagiou P, Vatten LJ, Mucci L, Trichopoulos D, Hellerstein S, Ekbom A, Adami HO, Hsieh CC. Pregnancy hormones, pre-eclampsia, and implications for breast cancer risk in the offspring. Cancer Epidemiol Biomarkers Prev. 2003 Jul; 12(7):647-50.
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  101. Tamimi RM, Lagiou P, Mucci LA, Hsieh CC, Adami HO, Trichopoulos D. Average energy intake among pregnant women carrying a boy compared with a girl. BMJ. 2003 Jun 7; 326(7401):1245-6.
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  102. Mucci LA, Lagiou P, Tamimi RM, Hsieh CC, Adami HO, Trichopoulos D. Pregnancy estriol, estradiol, progesterone and prolactin in relation to birth weight and other birth size variables (United States). Cancer Causes Control. 2003 May; 14(4):311-8.
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  103. Lagiou P, Hsieh CC, Trichopoulos D, Xu B, Wuu J, Mucci L, Tamimi R, Adami HO, Cnattingius S. Birthweight differences between USA and China and their relevance to breast cancer aetiology. Int J Epidemiol. 2003 Apr; 32(2):193-8.
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  104. Lagiou P, Tamimi R, Mucci LA, Trichopoulos D, Adami HO, Hsieh CC. Nausea and vomiting in pregnancy in relation to prolactin, estrogens, and progesterone: a prospective study. Obstet Gynecol. 2003 Apr; 101(4):639-44.
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  105. Lagiou P, Tamimi R, Lagiou A, Mucci L, Trichopoulos D. Is epidemiology implicating extremely low frequency electric and magnetic fields in childhood leukemia? Environ Health Prev Med. 2002 May; 7(2):33-9.
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  106. Tamimi RM, Lagiou P, Adami HO, Trichopoulos D. Prospects for chemoprevention of cancer. J Intern Med. 2002 Apr; 251(4):286-300.
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  107. Hagel M, George EL, Kim A, Tamimi R, Opitz SL, Turner CE, Imamoto A, Thomas SM. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol. 2002 Feb; 22(3):901-15.
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  108. Tamimi R, Adami HO. Testicular cancer. Adami HO, Hunter D, Trichopoulos D (eds.). Textbook of cancer epidemiology. 2002; 429-440.
  109. Lagiou P, Tamimi R, Lagiou A, Mucci L, Trichopoulos D. Is epidemiology implicating extremely low frequency electric and magnetic fields in childhood leukaemia?. Environ Health and Prev Med. 2002; 7:33-9.
  110. Weiderpass E, Ye W, Tamimi R, Trichopolous D, Nyren O, Vainio H, Adami HO. Alcoholism and risk for cancer of the cervix uteri, vagina, and vulva. Cancer Epidemiol Biomarkers Prev. 2001 Aug; 10(8):899-901.
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  111. Tamimi R, Mucci LA, Spanos E, Lagiou A, Benetou V, Trichopoulos D. Testosterone and oestradiol in relation to tobacco smoking, body mass index, energy consumption and nutrient intake among adult men. Eur J Cancer Prev. 2001 Jun; 10(3):275-80.
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  112. Mucci LA, Tamimi R, Lagiou P, Trichopoulou A, Benetou V, Spanos E, Trichopoulos D. Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system? BJU Int. 2001 Jun; 87(9):814-20.
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  113. Mucci LA, Wedren S, Tamimi RM, Trichopoulos D, Adami HO. The role of gene-environment interaction in the aetiology of human cancer: examples from cancers of the large bowel, lung and breast. J Intern Med. 2001 Jun; 249(6):477-93.
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  114. Mucci LA, Kuper HE, Tamimi R, Lagiou P, Spanos E, Trichopoulos D. Age at menarche and age at menopause in relation to hepatocellular carcinoma in women. BJOG. 2001 Mar; 108(3):291-4.
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  115. Kuper H, Mantzoros C, Lagiou P, Tzonou A, Tamimi R, Mucci L, Benetou V, Spanos E, Stuver SO, Trichopoulos D. Estrogens, testosterone and sex hormone binding globulin in relation to liver cancer in men. Oncology. 2001; 60(4):355-60.
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  116. Kuper H, Lagiou P, Mucci LA, Tamimi R, Benetou V, Trichopoulos D. Risk factors for cholangiocarcinoma in a low risk Caucasian population. Soz Praventivmed. 2001; 46(3):182-5.
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  117. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. Genomics. 1997 Mar 1; 40(2):355-7.
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  118. McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. Mol Cell Biol. 1996 Oct; 16(10):5792-800.
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  119. Tamimi R, Steingrimsson E, Copeland NG, Dyer-Montgomery K, Lee JE, Hernandez R, Jenkins NA, Tapscott SJ. The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2. Genomics. 1996 Jun 15; 34(3):418-21.
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