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Steven Bradley Lowen, Ph.D.

TitleAssistant Professor of Psychiatry
InstitutionMcLean Hospital
DepartmentPsychiatry
AddressMclean Hospital
Brain Imaging Center, Mail Stop 204
115 Mill St
Belmont MA 02478
Phone617/855-2254
Fax617/855-2770

 Biography 
 awards and honors
1981 - Runk prize in mathematics
1982 - Barge prize in mathematics
1984 - elected to Tau Beta Pi
1988 - Armstrong prize for teaching
1994 - elected to Sigma Xi

 Overview 
 overview
My long-term goal is to improve the lives of children, adolescents, and adults by elucidating various brain, mind, and psychiatric states, focusing mostly on drug abuse and drug dependency. In the service of this mission I apply bioengineering principles to psychiatry in order to develop more objective diagnoses and more effective treatment regimens.

I have taken the lead in the design of experiments and the data analysis stream for a number of functional MRI projects. Because olfactory stimuli are particularly salient, I have included them in many of these experiments, designing MRI-compatible olfactometers to deliver odors in the magnet. I also develop computer-based testing for attention deficit / hyperactivity disorder, and perform fractal analysis of human eye motion patterns.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Henry ME, Lauriat TL, Lowen SB, Churchill JH, Hodgkinson CA, Goldman D, Renshaw PF. Effects of citalopram and escitalopram on fMRI response to affective stimuli in healthy volunteers selected by serotonin transporter genotype. Psychiatry Res. 2013 Sep 30; 213(3):217-24.
    View in: PubMed
  2. Ogata N, Gillis TE, Liu X, Cunningham SM, Lowen SB, Adams BL, Sutherland-Smith J, Mintzopoulos D, Janes AC, Dodman NH, Kaufman MJ. Brain structural abnormalities in Doberman pinschers with canine compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug; 45:1-6.
    View in: PubMed
  3. Lukas SE, Lowen SB, Lindsey KP, Conn N, Tartarini W, Rodolico J, Mallya G, Palmer C, Penetar DM. Extended-release naltrexone (XR-NTX) attenuates brain responses to alcohol cues in alcohol-dependent volunteers: A bold FMRI study. Neuroimage. 2013 Sep; 78:176-85.
    View in: PubMed
  4. Licata SC, Nickerson LD, Lowen SB, Trksak GH, Maclean RR, Lukas SE. The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm. Neuroimage. 2013 Apr 15; 70:211-22.
    View in: PubMed
  5. Licata SC, Lowen SB, Trksak GH, Maclean RR, Lukas SE. Zolpidem reduces the blood oxygen level-dependent signal during visual system stimulation. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15; 35(7):1645-52.
    View in: PubMed
  6. Meade CS, Lowen SB, MacLean RR, Key MD, Lukas SE. fMRI brain activation during a delay discounting task in HIV-positive adults with and without cocaine dependence. Psychiatry Res. 2011 Jun 30; 192(3):167-75.
    View in: PubMed
  7. Elman I, Lowen S, Frederick BB, Chi W, Becerra L, Pitman RK. Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder. Biol Psychiatry. 2009 Dec 15; 66(12):1083-90.
    View in: PubMed
  8. Lowen SB, Nickerson LD, Levin JM. Differential effects of acute cocaine and placebo administration on visual cortical activation in healthy subjects measured using BOLD fMRI. Pharmacol Biochem Behav. 2009 Apr; 92(2):277-82.
    View in: PubMed
  9. Lowen SB, Lukas SE. A low-cost, MR-compatible olfactometer. Behav Res Methods. 2006 May; 38(2):307-13.
    View in: PubMed
  10. Anderson CM, Lowen SB, Renshaw PF. Emotional task-dependent low-frequency fluctuations and methylphenidate: Wavelet scaling analysis of 1/f-type fluctuations in fMRI of the cerebellar vermis. J Neurosci Methods. 2006 Feb 15; 151(1):52-61.
    View in: PubMed
  11. Blumberg MS, Seelke AM, Lowen SB, Karlsson KA. Dynamics of sleep-wake cyclicity in developing rats. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14860-4.
    View in: PubMed
  12. Aggarwal PS, Lowen SB, Colburn HS, Dolphin WF. Intrinsic oscillations in spike trains indicate non-renewal statistics due to convergence of inputs in dorsal cochlear nucleus neurons. Hear Res. 2005 Feb; 200(1-2):10-28.
    View in: PubMed
  13. Anderson CM, Kaufman MJ, Lowen SB, Rohan M, Renshaw PF, Teicher MH. Brain T2 relaxation times correlate with regional cerebral blood volume. MAGMA. 2005 Mar; 18(1):3-6.
    View in: PubMed
  14. Teicher MH, Lowen SB, Polcari A, Foley M, McGreenery CE. Novel strategy for the analysis of CPT data provides new insight into the effects of methylphenidate on attentional states in children with ADHD. J Child Adolesc Psychopharmacol. 2004; 14(2):219-32.
    View in: PubMed
  15. Teicher MH, Polcari A, Anderson CM, Andersen SL, Lowen SB, Navalta CP. Rate dependency revisited: understanding the effects of methylphenidate in children with attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol. 2003; 13(1):41-51.
    View in: PubMed
  16. Anderson CM, Polcari A, Lowen SB, Renshaw PF, Teicher MH. Effects of methylphenidate on functional magnetic resonance relaxometry of the cerebellar vermis in boys with ADHD. Am J Psychiatry. 2002 Aug; 159(8):1322-8.
    View in: PubMed
  17. Ke Y, Cohen BM, Lowen S, Hirashima F, Nassar L, Renshaw PF. Biexponential transverse relaxation (T(2)) of the proton MRS creatine resonance in human brain. Magn Reson Med. 2002 Feb; 47(2):232-8.
    View in: PubMed
  18. Lowen SB, Ozaki T, Kaplan E, Saleh BE, Teich MC. Fractal features of dark, maintained, and driven neural discharges in the cat visual system. Methods. 2001 Aug; 24(4):377-94.
    View in: PubMed
  19. Lowen SB, Liebovitch LS, White JA. Fractal ion-channel behavior generates fractal firing patterns in neuronal models. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 May; 59(5 Pt B):5970-80.
    View in: PubMed
  20. Lowen SB, Cash SS, Poo M, Teich MC. Quantal neurotransmitter secretion rate exhibits fractal behavior. J Neurosci. 1997 Aug 1; 17(15):5666-77.
    View in: PubMed
  21. Teich MC, Heneghan C, Lowen SB, Ozaki T, Kaplan E. Fractal character of the neural spike train in the visual system of the cat. J Opt Soc Am A Opt Image Sci Vis. 1997 Mar; 14(3):529-46.
    View in: PubMed
  22. Heneghan C, Chow CC, Collins JJ, Imhoff TT, Lowen SB, Teich MC. Information measures quantifying aperiodic stochastic resonance. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1996 Sep; 54(3):R2228-R2231.
    View in: PubMed
  23. Lowen SB, Teich MC. The periodogram and Allan variance reveal fractal exponents greater than unity in auditory-nerve spike trains. J Acoust Soc Am. 1996 Jun; 99(6):3585-91.
    View in: PubMed
  24. Bulsara AR, Elston TC, Doering CR, Lowen SB, Lindenberg K. Cooperative behavior in periodically driven noisy integrate-fire models of neuronal dynamics. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1996 Apr; 53(4):3958-3969.
    View in: PubMed
  25. Bulsara AR, Lowen SB, Rees CD. Reply to "Coherent stochastic resonance in the presence of a field" Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1995 Nov; 52(5):5712-5713.
    View in: PubMed
  26. Bulsara AR, Lowen SB, Rees CD. Cooperative behavior in the periodically modulated Wiener process: Noise-induced complexity in a model neutron. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994 Jun; 49(6):4989-5000.
    View in: PubMed
  27. Turcott RG, Lowen SB, Li E, Johnson DH, Tsuchitani C, Teich MC. A nonstationary Poisson point process describes the sequence of action potentials over long time scales in lateral-superior-olive auditory neurons. Biol Cybern. 1994; 70(3):209-17.
    View in: PubMed
  28. Lowen SB, Teich MC. Fractal renewal processes generate 1/f noise. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1993 Feb; 47(2):992-1001.
    View in: PubMed
  29. Lowen SB, Teich MC. Auditory-nerve action potentials form a nonrenewal point process over short as well as long time scales. J Acoust Soc Am. 1992 Aug; 92(2 Pt 1):803-6.
    View in: PubMed
  30. Lowen SB, Teich MC. Fractal renewal processes as a model of charge transport in amorphous semiconductors. Phys Rev B Condens Matter. 1992 Jul 15; 46(3):1816-1819.
    View in: PubMed
  31. Lowen SB, Teich MC. Doubly stochastic Poisson point process driven by fractal shot noise. Phys Rev A. 1991 Apr 15; 43(8):4192-4215.
    View in: PubMed
  32. Lowen SB, Teich MC. Fractal shot noise. Phys Rev Lett. 1989 Oct 23; 63(17):1755-1759.
    View in: PubMed
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