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Monica Gostissa, Ph.D.

TitleInstructor in Pediatrics
InstitutionChildren's Hospital Boston
DepartmentPediatrics
AddressChildren's Hospital
Immune Disease Institute Alt Lab
1 Blackfan Circle
Boston MA 02115
Phone617/919-2606
Fax617/278-3168

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gostissa M, Bianco JM, Malkin DJ, Kutok JL, Rodig SJ, Morse HC, Bassing CH, Alt FW. Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2934-9.
    View in: PubMed
  2. Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2473-8.
    View in: PubMed
  3. Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 2011 Sep 30; 147(1):107-19.
    View in: PubMed
  4. Gostissa M, Alt FW, Chiarle R. Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol. 2011; 29:319-50.
    View in: PubMed
  5. Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells. 2010 Jan; 28(1):64-74.
    View in: PubMed
  6. Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW. The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol. 2010; 106:93-133.
    View in: PubMed
  7. Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW. Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region. Nature. 2009 Dec 10; 462(7274):803-7.
    View in: PubMed
  8. Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 2009 Jul 9; 460(7252):231-6.
    View in: PubMed
  9. Gostissa M, Ranganath S, Bianco JM, Alt FW. Chromosomal location targets different MYC family gene members for oncogenic translocations. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2265-70.
    View in: PubMed
  10. Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med. 2008 Dec 22; 205(13):3079-90.
    View in: PubMed
  11. Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 2008 Jun 15; 22(12):1662-76.
    View in: PubMed
  12. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20; 21(2):201-14.
    View in: PubMed
  13. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell. 2006 Jan 20; 21(2):187-200.
    View in: PubMed
  14. Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, Gostissa M, Dobbelstein M, Del Sal G, Piaggio G, Mantovani R. Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. Mol Cell Biol. 2005 May; 25(9):3737-51.
    View in: PubMed
  15. Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. DNA repair, genome stability, and aging. Cell. 2005 Feb 25; 120(4):497-512.
    View in: PubMed
  16. Gostissa M, Morelli M, Mantovani F, Guida E, Piazza S, Collavin L, Brancolini C, Schneider C, Del Sal G. The transcriptional repressor hDaxx potentiates p53-dependent apoptosis. J Biol Chem. 2004 Nov 12; 279(46):48013-23.
    View in: PubMed
  17. Mantovani F, Gostissa M, Collavin L, Del Sal G. KeePin' the p53 family in good shape. Cell Cycle. 2004 Jul; 3(7):905-11.
    View in: PubMed
  18. Mantovani F, Piazza S, Gostissa M, Strano S, Zacchi P, Mantovani R, Blandino G, Del Sal G. Pin1 links the activities of c-Abl and p300 in regulating p73 function. Mol Cell. 2004 Jun 4; 14(5):625-36.
    View in: PubMed
  19. Collavin L, Gostissa M, Avolio F, Secco P, Ronchi A, Santoro C, Del Sal G. Modification of the erythroid transcription factor GATA-1 by SUMO-1. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8870-5.
    View in: PubMed
  20. Tessari MA, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno C, Caretti G, Imbriano C, Mantovani R, Del Sal G, Giancotti V, Manfioletti G. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol Cell Biol. 2003 Dec; 23(24):9104-16.
    View in: PubMed
  21. Tullo A, Mastropasqua G, Bourdon JC, Centonze P, Gostissa M, Costanzo A, Levrero M, Del Sal G, Saccone C, Sbisà E. Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target. Oncogene. 2003 Nov 27; 22(54):8738-48.
    View in: PubMed
  22. Gostissa M, Hofmann TG, Will H, Del Sal G. Regulation of p53 functions: let's meet at the nuclear bodies. Curr Opin Cell Biol. 2003 Jun; 15(3):351-7.
    View in: PubMed
  23. Zacchi P, Gostissa M, Uchida T, Salvagno C, Avolio F, Volinia S, Ronai Z, Blandino G, Schneider C, Del Sal G. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature. 2002 Oct 24; 419(6909):853-7.
    View in: PubMed
  24. D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol. 2002 Jan; 4(1):11-9.
    View in: PubMed
  25. Fogal V, Gostissa M, Sandy P, Zacchi P, Sternsdorf T, Jensen K, Pandolfi PP, Will H, Schneider C, Del Sal G. Regulation of p53 activity in nuclear bodies by a specific PML isoform. EMBO J. 2000 Nov 15; 19(22):6185-95.
    View in: PubMed
  26. Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G. p53 is involved in the p120E4F-mediated growth arrest. Oncogene. 2000 Jan 13; 19(2):188-99.
    View in: PubMed
  27. Gostissa M, Hengstermann A, Fogal V, Sandy P, Schwarz SE, Scheffner M, Del Sal G. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. EMBO J. 1999 Nov 15; 18(22):6462-71.
    View in: PubMed
  28. Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G. Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. Cytogenet Cell Genet. 1998; 82(1-2):99-100.
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  29. Goruppi S, Yamane H, Marcandalli P, Garcia A, Clogston C, Gostissa M, Varnum B, Schneider C. The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation. FEBS Lett. 1997 Sep 22; 415(1):59-63.
    View in: PubMed
  30. Marcandalli P, Gostissa M, Varnum B, Goruppi S, Schneider C. Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6. FEBS Lett. 1997 Sep 22; 415(1):56-8.
    View in: PubMed
  31. Saccone S, Marcandalli P, Gostissa M, Schneider C, Della Valle G. Assignment of the human GAS6 gene to chromosome 13q34 by fluorescence in situ hybridization. Genomics. 1995 Nov 1; 30(1):129-31.
    View in: PubMed
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