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Patricia Ann Fraser, M.D.

TitleAssociate Clinical Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressGenzyme Center
675 W. Kendall St
Cambridge MA 02142
Phone617/732-5348
Fax617/768-6416

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ruiz-Narvaez EA, Fraser PA, Palmer JR, Cupples LA, Reich D, Wang YA, Rioux JD, Rosenberg L. MHC region and risk of systemic lupus erythematosus in African American women. Hum Genet. 2011 Dec; 130(6):807-15.
    View in: PubMed
  2. Costenbader KH, Khamashta M, Ruiz-Garcia S, Perez-Rodriguez MT, Petri M, Elliott J, Manzi S, Karlson EW, Turner-Stokes T, Bermas B, Coblyn J, Massarotti E, Schur P, Fraser P, Navarro I, Hanly JG, Shaver TS, Katz RS, Chakravarty E, Fortin PR, Sanchez ML, Liu J, Michaud K, Alarcón GS, Wolfe F. Development and initial validation of a self-assessed lupus organ damage instrument. Arthritis Care Res (Hoboken). 2010 Apr; 62(4):559-68.
    View in: PubMed
  3. Karlson EW, Chang SC, Cui J, Chibnik LB, Fraser PA, De Vivo I, Costenbader KH. Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis. Ann Rheum Dis. 2010 Jan; 69(1):54-60.
    View in: PubMed
  4. Karlson EW, Chibnik LB, McGrath M, Chang SC, Keenan BT, Costenbader KH, Fraser PA, Tworoger S, Hankinson SE, Lee IM, Buring J, De Vivo I. A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis. Arthritis Res Ther. 2009; 11(3):R97.
    View in: PubMed
  5. Norman PJ, Abi-Rached L, Gendzekhadze K, Hammond JA, Moesta AK, Sharma D, Graef T, McQueen KL, Guethlein LA, Carrington CV, Chandanayingyong D, Chang YH, Crespí C, Saruhan-Direskeneli G, Hameed K, Kamkamidze G, Koram KA, Layrisse Z, Matamoros N, Milà J, Park MH, Pitchappan RM, Ramdath DD, Shiau MY, Stephens HA, Struik S, Tyan D, Verity DH, Vaughan RW, Davis RW, Fraser PA, Riley EM, Ronaghi M, Parham P. Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes. Genome Res. 2009 May; 19(5):757-69.
    View in: PubMed
  6. Bulwin GC, Wälter S, Schlawinsky M, Heinemann T, Schulze A, Höhne W, Krause G, Kalka-Moll W, Fraser P, Volk HD, Löhler J, Milford EL, Utku N. HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo. PLoS One. 2008; 3(2):e1576.
    View in: PubMed
  7. Norman PJ, Abi-Rached L, Gendzekhadze K, Korbel D, Gleimer M, Rowley D, Bruno D, Carrington CV, Chandanayingyong D, Chang YH, Crespí C, Saruhan-Direskeneli G, Fraser PA, Hameed K, Kamkamidze G, Koram KA, Layrisse Z, Matamoros N, Milà J, Park MH, Pitchappan RM, Ramdath DD, Shiau MY, Stephens HA, Struik S, Verity DH, Vaughan RW, Tyan D, Davis RW, Riley EM, Ronaghi M, Parham P. Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans. Nat Genet. 2007 Sep; 39(9):1092-9.
    View in: PubMed
  8. Karlson EW, Watts J, Signorovitch J, Bonetti M, Wright E, Cooper GS, McAlindon TE, Costenbader KH, Massarotti EM, Fitzgerald LM, Jajoo R, Husni ME, Fossel AH, Pankey H, Ding WZ, Knorr R, Condon S, Fraser PA. Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus project. Arthritis Rheum. 2007 Jan; 56(1):244-54.
    View in: PubMed
  9. Cooper GS, Parks CG, Schur PS, Fraser PA. Occupational and environmental associations with antinuclear antibodies in a general population sample. J Toxicol Environ Health A. 2006 Dec; 69(23):2063-9.
    View in: PubMed
  10. Finckh A, Cooper GS, Chibnik LB, Costenbader KH, Watts J, Pankey H, Fraser PA, Karlson EW. Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban women. Arthritis Rheum. 2006 Nov; 54(11):3648-54.
    View in: PubMed
  11. Karlson EW, Costenbader KH, McAlindon TE, Massarotti EM, Fitzgerald LM, Jajoo R, Husni E, Wright EA, Pankey H, Fraser PA. High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women. Lupus. 2005; 14(10):832-6.
    View in: PubMed
  12. Tian W, Boggs DA, Uko G, Essiet A, Inyama M, Banjoko B, Adewole T, Ding WZ, Mohseni M, Fritz R, Chen DF, Palmer LJ, Fraser PA. MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry. Genes Immun. 2003 Oct; 4(7):500-5.
    View in: PubMed
  13. Fraser PA, Ding WZ, Mohseni M, Treadwell EL, Dooley MA, St Clair EW, Gilkeson GS, Cooper GS. Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for autoimmunity. J Rheumatol. 2003 Feb; 30(2):276-82.
    View in: PubMed
  14. Baena A, Leung JY, Sullivan AD, Landires I, Vasquez-Luna N, Quiñones-Berrocal J, Fraser PA, Uko GP, Delgado JC, Clavijo OP, Thim S, Meshnick SR, Nyirenda T, Yunis EJ, Goldfeld AE. TNF-alpha promoter single nucleotide polymorphisms are markers of human ancestry. Genes Immun. 2002 Dec; 3(8):482-7.
    View in: PubMed
  15. Jordan JM, Lawrence R, Kington R, Fraser P, Karlson E, Lorig K, Liang MH. Ethnic health disparities in arthritis and musculoskeletal diseases: report of a scientific conference. Arthritis Rheum. 2002 Sep; 46(9):2280-6.
    View in: PubMed
  16. Rajsbaum R, Fici D, Boggs DA, Fraser PA, Flores-Villanueva PO, Awdeh ZL. Linkage disequilibrium between HLA-DPB1 alleles and retinoid X receptor beta haplotypes. Hum Immunol. 2002 Sep; 63(9):771-8.
    View in: PubMed
  17. Adamashvili I, Fraser PA, Milford EL, Sittig K, Gebel H, Zibari G, Pressly T, McDonald JC. Soluble HLA-II expression in African-Americans. Inflamm Res. 2002 Jun; 51(6):290-4.
    View in: PubMed
  18. Husni ME, Maier AL, Mease PJ, Overman SS, Fraser P, Gravallese EM, Weinblatt ME. Etanercept in the treatment of adult patients with Still's disease. Arthritis Rheum. 2002 May; 46(5):1171-6.
    View in: PubMed
  19. Tian W, Boggs DA, Ding WZ, Chen DF, Fraser PA. MICA genetic polymorphism and linkage disequilibrium with HLA-B in 29 African-American families. Immunogenetics. 2001 Dec; 53(9):724-8.
    View in: PubMed
  20. Rajsbaum R, Fici D, Fraser PA, Flores-Villanueva PO, Awdeh ZL. Polymorphism of the human retinoid X receptor beta and linkage disequilibrium with HLA-DPB1. Tissue Antigens. 2001 Jul; 58(1):24-9.
    View in: PubMed
  21. Uko GP, Fraser PA, Awdeh ZL, Fici DA, Crawford KD, Larsen CE, Alper CA. Hepatitis B surface antigen- and tetanus toxoid-specific clonal expansion of CD4+ cells in vitro determined by TCRBV CDR3 length and nucleotide sequence. Genes Immun. 2001 Feb; 2(1):11-9.
    View in: PubMed
  22. Fraser PA, Lu LY, Ding WZ, Najundaswamy SN, Chen DF, Uko G, Tonks S. HLA-B44031;DRB1*1503 and other sub-Saharan African major histocompatibility complex haplotypes in African Americans and Afro-Caribbeans carry C4A gene deletions: implications for ethnicity-specific lupus susceptibility genes. Arthritis Rheum. 2000 Oct; 43(10):2378-9.
    View in: PubMed
  23. Uko GP, Lu LY, Asuquo MA, Fici D, Mahan S, Awdeh Z, Udim ER, Ding W, Umana U, Adewole T, Fraser PA. HLA-DRB1 leprogenic motifs in nigerian population groups. Clin Exp Immunol. 1999 Oct; 118(1):56-62.
    View in: PubMed
  24. Clavijo OP, Delgado JC, Yu N, Fraser PA, Yunis EJ. HLA-Cw*1701 is associated with two sub-Saharan African-derived HLA haplotypes: HLA-B*4201, DRB1*03 and HLA-B*4202 without DRB1*03. Tissue Antigens. 1999 Sep; 54(3):303-6.
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  25. Linker-Israeli M, Wallace DJ, Prehn J, Michael D, Honda M, Taylor KD, Paul-Labrador M, Fischel-Ghodsian N, Fraser PA, Klinenberg JR. Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression. Genes Immun. 1999 Sep; 1(1):45-52.
    View in: PubMed
  26. Fraser PA, Lu LY, DeCeulaer K, Schur PH, Fici D, Awdeh Z, Ding WZ, Levitan E, Lew R, Uko G, Gonzalez C. CD4 TCRBV CDR3 analysis in prevalent SLE cases from two ethnic groups. Lupus. 1999; 8(4):311-9.
    View in: PubMed
  27. Wolf RE, Adamashvili IM, Gelder FB, Hall VC, Fraser PA, McDonald JC. Soluble HLA-I in rheumatic diseases. Hum Immunol. 1998 Oct; 59(10):644-9.
    View in: PubMed
  28. Weinblatt ME, Maier AL, Fraser PA, Coblyn JS. Longterm prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy. J Rheumatol. 1998 Feb; 25(2):238-42.
    View in: PubMed
  29. Lu LY, Ding WZ, Fici D, Deulofeut R, Cheng HH, Cheu CC, Sung PK, Schur PH, Fraser PA. Molecular analysis of major histocompatibility complex allelic associations with systemic lupus erythematosus in Taiwan. Arthritis Rheum. 1997 Jun; 40(6):1138-45.
    View in: PubMed
  30. Fraser PA, Yunis EJ, Alper CA. Excess admixture proportion of extended major histocompatability complex haplotypes of Caucasian origin among rheumatoid arthritis associated haplotypes in African Americans and Afro-Caribbeans. Ethn Health. 1996 May; 1(2):153-9.
    View in: PubMed
  31. Adamashvili IM, McDonald JC, Fraser PA, Milford EL, Pressly TA, Gelder FB. Soluble class I HLA antigens in patients with rheumatoid arthritis and their families. J Rheumatol. 1995 Jun; 22(6):1025-31.
    View in: PubMed
  32. Iglesias A, Deulofeut H, Dubey DP, Salazar M, Egea E, Yunis EJ, Fraser PA. Functional deficiency of antigen-presenting cells in the synovial fluid of rheumatoid arthritis. Hum Immunol. 1992 Oct; 35(2):109-15.
    View in: PubMed
  33. Weinblatt ME, Weissman BN, Holdsworth DE, Fraser PA, Maier AL, Falchuk KR, Coblyn JS. Long-term prospective study of methotrexate in the treatment of rheumatoid arthritis. 84-month update. Arthritis Rheum. 1992 Feb; 35(2):129-37.
    View in: PubMed
  34. Fraser PA, Awdeh ZL, Ronco P, Simon S, Moore B, Fici D, Marcus-Bagley D, Yunis EJ, Alper CA. C4B gene polymorphisms among African and African-American HLA-Bw42-DRw18 haplotypes. Immunogenetics. 1991; 34(1):52-6.
    View in: PubMed
  35. Fraser PA, Stern S, Larson MG, Marcus-Bagley D, Awdeh Z, Glass DN, Alper CA. HLA extended haplotypes in childhood and adult onset HLA-DR4-associated arthropathies. Tissue Antigens. 1990 Feb; 35(2):56-9.
    View in: PubMed
  36. Fraser PA, Moore B, Stein R, Alosco S, Johnson AH, Marcus-Bagley D, Awdeh Z, Yunis EJ, Alper CA. Complotypes in individuals of African origin: frequencies and possible extended MHC haplotypes. Immunogenetics. 1990; 31(2):89-93.
    View in: PubMed
  37. Spragg J, Coblyn JS, Fraser PA, Austen KF, Weinblatt ME. The effect of cyclosporine on urinary kallikrein excretion in patients with rheumatoid arthritis. Adv Exp Med Biol. 1989; 247A:389-92.
    View in: PubMed
  38. Fraser PA, Hoch S, Erlandson D, Partridge R, Jackson JM. The timing of menarche in juvenile rheumatoid arthritis. J Adolesc Health Care. 1988 Nov; 9(6):483-7.
    View in: PubMed
  39. Fraser PA, Stern SH, Coblyn JS, Weinblatt ME, Holdsworth DE, Green P, Shriner S, Mindnich D, Larson M. Immunogenetic and racial determinants of gold toxicity in rheumatoid arthritis. J Natl Med Assoc. 1988 Feb; 80(2):162-5.
    View in: PubMed
  40. Weinblatt ME, Trentham DE, Fraser PA, Holdsworth DE, Falchuk KR, Weissman BN, Coblyn JS. Long-term prospective trial of low-dose methotrexate in rheumatoid arthritis. Arthritis Rheum. 1988 Feb; 31(2):167-75.
    View in: PubMed
  41. Turka LA, Ramos EL, Leggat JE, Milford EL, Fraser PA, Carpenter CB. Antigen specificity of mixed lymphocyte response-induced suppressor cells. Hum Immunol. 1987 Dec; 20(4):293-306.
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  42. Sperling RI, Weinblatt M, Robin JL, Ravalese J, Hoover RL, House F, Coblyn JS, Fraser PA, Spur BW, Robinson DR, et al. Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. Arthritis Rheum. 1987 Sep; 30(9):988-97.
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  43. Weinblatt ME, Fraser PA, Anderson R, Coblyn JS, Trentham DE. Diminution of the T8 subset by amiprilose hydrochloride in refractory RA. J Rheumatol. 1987 Aug; 14(4):859-60.
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  44. Weinblatt ME, Coblyn JS, Fraser PA, Anderson RJ, Spragg J, Trentham DE, Austen KF. Cyclosporin A treatment of refractory rheumatoid arthritis. Arthritis Rheum. 1987 Jan; 30(1):11-7.
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  45. Aaron S, Fraser PA, Jackson JM, Larson M, Glass DN. Sex ratio and sibship size in juvenile rheumatoid arthritis kindreds. Arthritis Rheum. 1985 Jul; 28(7):753-8.
    View in: PubMed
  46. Aaron S, Miller ML, Howard J, Fraser PA, Jackson JM, Larson MG, Glass DN. Complementation with HLA-A and HLA-D locus alleles in ankylosing spondylitis with peripheral arthritis. J Rheumatol. 1985 Jun; 12(3):553-7.
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  47. Weinblatt ME, Coblyn JS, Fox DA, Fraser PA, Holdsworth DE, Glass DN, Trentham DE. Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med. 1985 Mar 28; 312(13):818-22.
    View in: PubMed
  48. Miller ML, Fraser PA, Jackson JM, Larson MG, Petersen RA, Chylack LT, Glass DN. Inherited predisposition to iridocyclitis with juvenile rheumatoid arthritis: selectivity among HLA-DR5 haplotypes. Proc Natl Acad Sci U S A. 1984 Jun; 81(11):3539-42.
    View in: PubMed
  49. Fraser PA, Schur PH. Hypoimmunoglobulinemia D: frequency, family studies, and association with HLA. Clin Immunol Immunopathol. 1981 Apr; 19(1):67-74.
    View in: PubMed
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