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Anna-Liisa Brownell, Ph.D.

TitleProfessor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Radiology/Martinos Biomedical Imaging Center
149 13th Street
Charlestown MA 02129
Phone617/726-3807
Fax617/726-7422

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kil KE, Zhang Z, Jokivarsi K, Gong C, Choi JK, Kura S, Brownell AL. Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4). Bioorg Med Chem. 2013 Oct 1; 21(19):5955-62.
    View in: PubMed
  2. Chen YI, Cypess AM, Sass CA, Brownell AL, Jokivarsi KT, Kahn CR, Kwong KK. Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging. Obesity (Silver Spring). 2012 Jul; 20(7):1519-26.
    View in: PubMed
  3. Wang JQ, Zhang Z, Kuruppu D, Brownell AL. Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo. Bioorg Med Chem Lett. 2012 Mar 1; 22(5):1958-62.
    View in: PubMed
  4. Shoup TM, Elmaleh DR, Brownell AL, Zhu A, Guerrero JL, Fischman AJ. Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium ion. A potential myocardial blood flow agent for PET. Mol Imaging Biol. 2011 Jun; 13(3):511-7.
    View in: PubMed
  5. Drouin-Ouellet J, Brownell AL, Saint-Pierre M, Fasano C, Emond V, Trudeau LE, Lévesque D, Cicchetti F. Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions. Glia. 2011 Feb; 59(2):188-99.
    View in: PubMed
  6. Black YD, Xiao D, Pellegrino D, Kachroo A, Brownell AL, Schwarzschild MA. Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease. Neurosci Lett. 2010 Dec 17; 486(3):161-5.
    View in: PubMed
  7. Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiol Dis. 2009 Sep; 35(3):348-51.
    View in: PubMed
  8. Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV. Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J Neurosci. 2009 Apr 22; 29(16):5193-201.
    View in: PubMed
  9. Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD, Scherrer-Crosbie M. A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2495-502.
    View in: PubMed
  10. Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 2008 Aug 1; 42(1):248-51.
    View in: PubMed
  11. Wang JQ, Tueckmantel W, Zhu A, Pellegrino D, Brownell AL. Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5. Synapse. 2007 Dec; 61(12):951-61.
    View in: PubMed
  12. Pellegrino D, Cicchetti F, Wang X, Zhu A, Yu M, Saint-Pierre M, Brownell AL. Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats. J Nucl Med. 2007 Jul; 48(7):1147-53.
    View in: PubMed
  13. Cicchetti F, Gross RE, Bulte JW, Owen M, Chen I, Saint-Pierre M, Wang X, Yu M, Brownell AL. Dual-modality in vivo monitoring of subventricular zone stem cell migration and metabolism. Contrast Media Mol Imaging. 2007 May-Jun; 2(3):130-8.
    View in: PubMed
  14. Kuruppu D, Brownell AL, Zhu A, Yu M, Wang X, Kulu Y, Fuchs BC, Kawasaki H, Tanabe KK. Positron emission tomography of herpes simplex virus 1 oncolysis. Cancer Res. 2007 Apr 1; 67(7):3295-300.
    View in: PubMed
  15. Zhu A, Wang X, Yu M, Wang JQ, Brownell AL. Evaluation of four pyridine analogs to characterize 6-OHDA-induced modulation of mGluR5 function in rat brain using microPET studies. J Cereb Blood Flow Metab. 2007 Sep; 27(9):1623-31.
    View in: PubMed
  16. Paley EL, Denisova G, Sokolova O, Posternak N, Wang X, Brownell AL. Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models. Neuromolecular Med. 2007; 9(1):55-82.
    View in: PubMed
  17. Elmaleh DR, Fischman AJ, Tawakol A, Zhu A, Shoup TM, Hoffmann U, Brownell AL, Zamecnik PC. Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15992-6.
    View in: PubMed
  18. Sánchez-Pernaute R, Brownell AL, Jenkins BG, Isacson O. Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging. Toxicol Appl Pharmacol. 2005 Sep 1; 207(2 Suppl):251-6.
    View in: PubMed
  19. Yu M, Tueckmantel W, Wang X, Zhu A, Kozikowski AP, Brownell AL. Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors. Nucl Med Biol. 2005 Aug; 32(6):631-40.
    View in: PubMed
  20. Wang X, Sarkar A, Cicchetti F, Yu M, Zhu A, Jokivarsi K, Saint-Pierre M, Brownell AL. Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease. J Neurol Sci. 2005 Apr 15; 231(1-2):57-66.
    View in: PubMed
  21. Jenkins BG, Sanchez-Pernaute R, Brownell AL, Chen YC, Isacson O. Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. J Neurosci. 2004 Oct 27; 24(43):9553-60.
    View in: PubMed
  22. McNaught KS, Perl DP, Brownell AL, Olanow CW. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul; 56(1):149-62.
    View in: PubMed
  23. Brownell AL, Chen YI, Yu M, Wang X, Dedeoglu A, Cicchetti F, Jenkins BG, Beal MF. 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy. J Neurochem. 2004 Jun; 89(5):1206-14.
    View in: PubMed
  24. Sánchez-Pernaute R, Ferree A, Cooper O, Yu M, Brownell AL, Isacson O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J Neuroinflammation. 2004 May 17; 1(1):6.
    View in: PubMed
  25. Brownell AL, Canales K, Chen YI, Jenkins BG, Owen C, Livni E, Yu M, Cicchetti F, Sanchez-Pernaute R, Isacson O. Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model. Neuroimage. 2003 Oct; 20(2):1064-75.
    View in: PubMed
  26. Yu M, Någren K, Chen YI, Livni E, Elmaleh D, Kozikowski A, Wang X, Jokivarsi K, Brownell AL. Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo[2.1.1] -hexane -5-carboxylate, a potential neuroprotective drug. Life Sci. 2003 Aug 8; 73(12):1577-85.
    View in: PubMed
  27. Sánchez-Pernaute R, Brownell AL, Isacson O. Functional imaging of the dopamine system: in vivo evaluation of dopamine deficiency and restoration. Neurotoxicology. 2002 Oct; 23(4-5):469-78.
    View in: PubMed
  28. Cicchetti F, Brownell AL, Williams K, Chen YI, Livni E, Isacson O. Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur J Neurosci. 2002 Mar; 15(6):991-8.
    View in: PubMed
  29. Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2344-9.
    View in: PubMed
  30. Isacson O, van Horne C, Schumacher JM, Brownell AL. Improved surgical cell therapy in Parkinson's disease. Physiological basis and new transplantation methodology. Adv Neurol. 2001; 86:447-54.
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  31. Veis A, Tompkins K, Alvares K, Wei K, Wang L, Wang XS, Brownell AG, Jengh SM, Healy KE. Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo. J Biol Chem. 2000 Dec 29; 275(52):41263-72.
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  32. Madras BK, Miller GM, Meltzer PC, Brownell AL, Fischman AJ. Molecular and regional targets of cocaine in primate brain: liberation from prosaic views. Addict Biol. 2000 Jul 1; 5(3):351-9.
    View in: PubMed
  33. Nguyen TV, Brownell AL, Iris Chen YC, Livni E, Coyle JT, Rosen BR, Cavagna F, Jenkins BG. Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET. Synapse. 2000 Apr; 36(1):57-65.
    View in: PubMed
  34. Chen YI, Brownell AL, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BG. Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. Neuroreport. 1999 Sep 29; 10(14):2881-6.
    View in: PubMed
  35. Brownell AL, Jenkins BG, Isacson O. Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease. Biomed Pharmacother. 1999 Apr; 53(3):131-40.
    View in: PubMed
  36. Jenkins BG, Chen YI, Kuestermann E, Makris NM, Nguyen TV, Kraft E, Brownell AL, Rosas HD, Kennedy DN, Rosen BR, Koroshetz WJ, Beal MF. An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques. Ann N Y Acad Sci. 1999; 893:214-42.
    View in: PubMed
  37. Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD, Isacson O. Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease. Nat Med. 1998 Nov; 4(11):1308-12.
    View in: PubMed
  38. Brownell AL, Livni E, Galpern W, Isacson O. In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants. Ann Neurol. 1998 Mar; 43(3):387-90.
    View in: PubMed
  39. Chen YC, Galpern WR, Brownell AL, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen BR, Jenkins BG. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn Reson Med. 1997 Sep; 38(3):389-98.
    View in: PubMed
  40. Brownell AL, Elmaleh DR, Meltzer PC, Shoup TM, Brownell GL, Fischman AJ, Madras BK. Cocaine congeners as PET imaging probes for dopamine terminals. J Nucl Med. 1996 Jul; 37(7):1186-92.
    View in: PubMed
  41. Burns LH, Pakzaban P, Deacon TW, Brownell AL, Tatter SB, Jenkins BG, Isacson O. Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease. Neuroscience. 1995 Feb; 64(4):1007-17.
    View in: PubMed
  42. Tsujino S, Shanske S, Brownell AK, Haller RG, DiMauro S. Molecular genetic studies of muscle lactate dehydrogenase deficiency in white patients. Ann Neurol. 1994 Oct; 36(4):661-5.
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  43. Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK. A method for labeling cells for positron emission tomography (PET) studies. J Immunol Methods. 1994 Sep 30; 175(1):79-87.
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  44. Wüllner U, Pakzaban P, Brownell AL, Hantraye P, Burns L, Shoup T, Elmaleh D, Petto AJ, Spealman RD, Brownell GL, et al. Dopamine terminal loss and onset of motor symptoms in MPTP-treated monkeys: a positron emission tomography study with 11C-CFT. Exp Neurol. 1994 Apr; 126(2):305-9.
    View in: PubMed
  45. Madras BK, Elmaleh DR, Meltzer PC, Liang AY, Brownell GL, Brownell AL. Positron emission tomography of cocaine binding sites on the dopamine transporter. NIDA Res Monogr. 1994; 138:57-69.
    View in: PubMed
  46. Brownell AL, Hantraye P, Wullner U, Hamberg L, Shoup T, Elmaleh DR, Frim DM, Madras BK, Brownell GL, Rosen BR, et al. PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates. Exp Neurol. 1994 Jan; 125(1):41-51.
    View in: PubMed
  47. Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK. Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors. Cancer Res. 1993 Dec 15; 53(24):5867-71.
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  48. Meltzer PC, Liang AY, Brownell AL, Elmaleh DR, Madras BK. Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging. J Med Chem. 1993 Apr 2; 36(7):855-62.
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  49. Rubin SC, Kairemo KJ, Brownell AL, Daghighian F, Federici MG, Pentlow KS, Finn RD, Lambrecht RM, Hoskins WJ, Lewis JL, et al. High-resolution positron emission tomography of human ovarian cancer in nude rats using 124I-labeled monoclonal antibodies. Gynecol Oncol. 1993 Jan; 48(1):61-7.
    View in: PubMed
  50. Hantraye P, Brownell AL, Elmaleh D, Spealman RD, Wüllner U, Brownell GL, Madras BK, Isacson O. Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism. Neuroreport. 1992 Mar; 3(3):265-8.
    View in: PubMed
  51. Schumacher JM, Hantraye P, Brownell AL, Riche D, Madras BK, Davenport PD, Maziere M, Elmaleh DR, Brownell GL, Isacson O. A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures. Cell Transplant. 1992; 1(4):313-22.
    View in: PubMed
  52. Brownell AL, Kano M, McKinstry RC, Moskowitz MA, Rosen BR, Brownell GL. PET and MR studies of experimental focal stroke. J Comput Assist Tomogr. 1991 May-Jun; 15(3):376-80.
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  53. Kallinowski F, Brownell AL, Vaupel P, Brownell GL. Combined tissue oxygen tension measurement and positron emission tomography studies on glucose utilization in oncogene-transformed cell line tumour xenografts in nude mice. Br J Radiol. 1991 Apr; 64(760):350-9.
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  54. Yaoita H, Uehara T, Brownell AL, Rabito CA, Ahmad M, Khaw BA, Fischman AJ, Strauss HW. Localization of technetium-99m-glucarate in zones of acute cerebral injury. J Nucl Med. 1991 Feb; 32(2):272-8.
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  55. Brownell AL, Karonen SL, Korpela H, Lindroth L, Aaltonen J, Nikkinen P, Lindgren J. A comparison of 131I-labeled antibodies, 2-deoxy-2-[18F]fluoro-D-glucose and 68Ga-EDTA in the imaging of human tumor xenografts in nude mice. Int J Rad Appl Instrum B. 1990; 17(3):281-6.
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  56. Launes J, Nikkinen P, Lindroth L, Brownell AL, Liewendahl K, Iivanainen M. Brain perfusion defect size in SPECT predicts outcome in cerebral infarction. Nucl Med Commun. 1989 Dec; 10(12):891-900.
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  57. Launes J, Nikkinen P, Lindroth L, Brownell AL, Liewendahl K, Iivanainen M. Diagnosis of acute herpes simplex encephalitis by brain perfusion single photon emission computed tomography. Lancet. 1988 May 28; 1(8596):1188-91.
    View in: PubMed
  58. Brownell AK, Engel AG. Experimental lipid storage myopathy. A quantitative ultrastructural and biochemical study. J Neurol Sci. 1978 Jan; 35(1):31-41.
    View in: PubMed
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