 Edward Meigs Brown, M.D.
| Title | Professor of Medicine |
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| Institution | Brigham and Women's Hospital |
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| Department | Medicine |
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| Address | BWH-Endocrine
221 Longwood Ave
Boston MA 02115
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| Phone | 617/732-5661 |
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| Fax | 617/732-5764 |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Brown EM. Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR). Biochem Pharmacol. 2010 Aug 1; 80(3):297-307.
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Jha RM, Mithal A, Malhotra N, Brown EM. Pilot case-control investigation of risk factors for hip fractures in the urban Indian population. BMC Musculoskelet Disord. 2010; 11:49.
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Yano S, Brown EM, Takase H, Wada A, Suzuki K, Kobayashi A, Sugimoto T. Calcium-corrected intact PTH: a clinically useful parameter for quantifying parathyroid function in patients undergoing hemodialysis. Nephron Clin Pract. 2010; 115(1):c51-8.
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Sun W, Sun W, Liu J, Zhou X, Xiao Y, Karaplis A, Pollak MR, Brown E, Goltzman D, Miao D. Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. Development. 2010 Mar; 137(6):985-92.
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Kemp EH, Gavalas NG, Akhtar S, Krohn KJ, Pallais JC, Brown EM, Watson PF, Weetman AP. Mapping of human autoantibody binding sites on the calcium-sensing receptor. J Bone Miner Res. 2010 Jan; 25(1):132-40.
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Riccardi D, Brown EM. Physiology and pathophysiology of the calcium-sensing receptor in the kidney. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F485-99.
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Kemp EH, Gavalas NG, Krohn KJ, Brown EM, Watson PF, Weetman AP. Activating autoantibodies against the calcium-sensing receptor detected in two patients with autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab. 2009 Dec; 94(12):4749-56.
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Kantham L, Quinn SJ, Egbuna OI, Baxi K, Butters R, Pang JL, Pollak MR, Goltzman D, Brown EM. The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am J Physiol Endocrinol Metab. 2009 Oct; 297(4):E915-23.
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Brown EM. Anti-parathyroid and anti-calcium sensing receptor antibodies in autoimmune hypoparathyroidism. Endocrinol Metab Clin North Am. 2009 Jun; 38(2):437-45, x.
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Egbuna O, Quinn S, Kantham L, Butters R, Pang J, Pollak M, Goltzman D, Brown E. The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone. Am J Physiol Renal Physiol. 2009 Sep; 297(3):F720-8.
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Saidak Z, Mentaverri R, Brown EM. The role of the calcium-sensing receptor in the development and progression of cancer. Endocr Rev. 2009 Apr; 30(2):178-95.
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Huang Y, Zhou Y, Castiblanco A, Yang W, Brown EM, Yang JJ. Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response. Biochemistry. 2009 Jan 20; 48(2):388-98.
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Cetani F, Lemmi M, Cervia D, Borsari S, Cianferotti L, Pardi E, Ambrogini E, Banti C, Brown EM, Bagnoli P, Pinchera A, Marcocci C. Identification and functional characterization of loss-of-function mutations of the calcium-sensing receptor in four Italian kindreds with familial hypocalciuric hypercalcemia. Eur J Endocrinol. 2009 Mar; 160(3):481-9.
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Hurtel-Lemaire AS, Mentaverri R, Caudrillier A, Cournarie F, Wattel A, Kamel S, Terwilliger EF, Brown EM, Brazier M. The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. J Biol Chem. 2009 Jan 2; 284(1):575-84.
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Brown EM, Lian JB. New insights in bone biology: unmasking skeletal effects of the extracellular calcium-sensing receptor. Sci Signal. 2008; 1(35):pe40.
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Chattopadhyay N, Espinosa-Jeffrey A, Tfelt-Hansen J, Yano S, Bandyopadhyay S, Brown EM, de Vellis J. Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice. J Neurosci Res. 2008 Aug 1; 86(10):2159-67.
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Egbuna OI, Brown EM. Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations. Best Pract Res Clin Rheumatol. 2008 Mar; 22(1):129-48.
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Khairallah W, Fawaz A, Brown EM, El-Hajj Fuleihan G. Hypercalcemia and diabetes insipidus in a patient previously treated with lithium. Nat Clin Pract Nephrol. 2007 Jul; 3(7):397-404.
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Huang Y, Zhou Y, Yang W, Butters R, Lee HW, Li S, Castiblanco A, Brown EM, Yang JJ. Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor. J Biol Chem. 2007 Jun 29; 282(26):19000-10.
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Chattopadhyay N, Quinn SJ, Kifor O, Ye C, Brown EM. The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation. Biochem Pharmacol. 2007 Aug 1; 74(3):438-47.
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Gavalas NG, Kemp EH, Krohn KJ, Brown EM, Watson PF, Weetman AP. The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab. 2007 Jun; 92(6):2107-14.
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Bandyopadhyay S, Jeong KH, Hansen JT, Vassilev PM, Brown EM, Chattopadhyay N. Calcium-sensing receptor stimulates secretion of an interferon-gamma-induced monokine (CXCL10) and monocyte chemoattractant protein-3 in immortalized GnRH neurons. J Neurosci Res. 2007 Mar; 85(4):882-95.
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Bianco SD, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, Kos CH, Zhuang L, Freeman MR, Gouveia CH, Wu J, Luo H, Mauro T, Brown EM, Hediger MA. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res. 2007 Feb; 22(2):274-85.
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Brown EM. Clinical lessons from the calcium-sensing receptor. Nat Clin Pract Endocrinol Metab. 2007 Feb; 3(2):122-33.
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Quinn SJ, Kifor O, Kifor I, Butters RR, Brown EM. Role of the cytoskeleton in extracellular calcium-regulated PTH release. Biochem Biophys Res Commun. 2007 Mar 2; 354(1):8-13.
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Conigrave AD, Brown EM. Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G753-61.
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Chattopadhyay N, Jeong KH, Yano S, Huang S, Pang JL, Ren X, Terwilliger E, Kaiser UB, Vassilev PM, Pollak MR, Brown EM. Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E523-32.
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LaPlante JM, Sun M, Falardeau J, Dai D, Brown EM, Slaugenhaupt SA, Vassilev PM. Lysosomal exocytosis is impaired in mucolipidosis type IV. Mol Genet Metab. 2006 Dec; 89(4):339-48.
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Chattopadhyay N, Brown EM. Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. Mol Genet Metab. 2006 Nov; 89(3):189-202.
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Smajilovic S, Hansen JL, Christoffersen TE, Lewin E, Sheikh SP, Terwilliger EF, Brown EM, Haunso S, Tfelt-Hansen J. Extracellular calcium sensing in rat aortic vascular smooth muscle cells. Biochem Biophys Res Commun. 2006 Oct 6; 348(4):1215-23.
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Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature. 2006 Feb 2; 439(7076):599-603.
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Tfelt-Hansen J, Yano S, John Macleod R, Smajilovic S, Chattopadhyay N, Brown EM. High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells. Growth Factors. 2005 Jun; 23(2):117-23.
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Mallya SM, Gallagher JJ, Wild YK, Kifor O, Costa-Guda J, Saucier K, Brown EM, Arnold A. Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism. Mol Endocrinol. 2005 Oct; 19(10):2603-9.
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Yano S, Mentaverri R, Kanuparthi D, Bandyopadhyay S, Rivera A, Brown EM, Chattopadhyay N. Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts. Endocrinology. 2005 May; 146(5):2324-35.
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Brown EM. Editorial: mutant extracellular calcium-sensing receptors and severity of disease. J Clin Endocrinol Metab. 2005 Feb; 90(2):1246-8.
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Tfelt-Hansen J, Ferreira A, Yano S, Kanuparthi D, Romero JR, Brown EM, Chattopadhyay N. Calcium-sensing receptor activation induces nitric oxide production in H-500 Leydig cancer cells. Am J Physiol Endocrinol Metab. 2005 Jun; 288(6):E1206-13.
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Tfelt-Hansen J, Brown EM. The calcium-sensing receptor in normal physiology and pathophysiology: a review. Crit Rev Clin Lab Sci. 2005; 42(1):35-70.
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LaPlante JM, Ye CP, Quinn SJ, Goldin E, Brown EM, Slaugenhaupt SA, Vassilev PM. Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV. Biochem Biophys Res Commun. 2004 Oct 1; 322(4):1384-91.
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Yano S, Macleod RJ, Chattopadhyay N, Tfelt-Hansen J, Kifor O, Butters RR, Brown EM. Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation. Bone. 2004 Sep; 35(3):664-72.
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MacLeod RJ, Yano S, Chattopadhyay N, Brown EM. Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism. Biochem Biophys Res Commun. 2004 Jul 23; 320(2):455-60.
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Pallais JC, Kifor O, Chen YB, Slovik D, Brown EM. Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor. N Engl J Med. 2004 Jul 22; 351(4):362-9.
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Conigrave AD, Mun HC, Delbridge L, Quinn SJ, Wilkinson M, Brown EM. L-amino acids regulate parathyroid hormone secretion. J Biol Chem. 2004 Sep 10; 279(37):38151-9.
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Quinn SJ, Bai M, Brown EM. pH Sensing by the calcium-sensing receptor. J Biol Chem. 2004 Sep 3; 279(36):37241-9.
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Tfelt-Hansen J, Yano S, Bandyopadhyay S, Carroll R, Brown EM, Chattopadhyay N. Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. Endocrinology. 2004 Sep; 145(9):4222-31.
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Chattopadhyay N, Yano S, Tfelt-Hansen J, Rooney P, Kanuparthi D, Bandyopadhyay S, Ren X, Terwilliger E, Brown EM. Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. Endocrinology. 2004 Jul; 145(7):3451-62.
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Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature. 2004 Mar 18; 428(6980):328-32.
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Yano S, Brown EM, Chattopadhyay N. Calcium-sensing receptor in the brain. Cell Calcium. 2004 Mar; 35(3):257-64.
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Ye CP, Yano S, Tfelt-Hansen J, MacLeod RJ, Ren X, Terwilliger E, Brown EM, Chattopadhyay N. Regulation of a Ca2+-activated K+ channel by calcium-sensing receptor involves p38 MAP kinase. J Neurosci Res. 2004 Feb 15; 75(4):491-8.
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Chattopadhyay N, T-Felt Hansen J, Godbole MM, Brown EM. Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells. Brain Res Mol Brain Res. 2004 Feb 5; 121(1-2):146-50.
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VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J Clin Invest. 2004 Feb; 113(4):598-608.
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Kifor O, McElduff A, LeBoff MS, Moore FD, Butters R, Gao P, Cantor TL, Kifor I, Brown EM. Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab. 2004 Feb; 89(2):548-56.
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Brown EM. Calcium sensing by endocrine cells. Endocr Pathol. 2004; 15(3):187-219.
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Goswami R, Brown EM, Kochupillai N, Gupta N, Rani R, Kifor O, Chattopadhyay N. Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism. Eur J Endocrinol. 2004 Jan; 150(1):9-18.
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Shiohara M, Mori T, Mei B, Brown EM, Watanabe T, Yasuda T. A novel gain-of-function mutation (F821L) in the transmembrane domain of calcium-sensing receptor is a cause of severe sporadic hypoparathyroidism. Eur J Pediatr. 2004 Feb; 163(2):94-8.
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Tfelt-Hansen J, Chattopadhyay N, Yano S, Kanuparthi D, Rooney P, Schwarz P, Brown EM. Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy. Endocrinology. 2004 Mar; 145(3):1211-7.
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Tfelt-Hansen J, Schwarz P, Terwilliger EF, Brown EM, Chattopadhyay N. Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer. Endocrinology. 2003 Dec; 144(12):5188-93.
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Kifor O, Kifor I, Moore FD, Butters RR, Cantor T, Gao P, Brown EM. Decreased expression of caveolin-1 and altered regulation of mitogen-activated protein kinase in cultured bovine parathyroid cells and human parathyroid adenomas. J Clin Endocrinol Metab. 2003 Sep; 88(9):4455-64.
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Peng JB, Brown EM, Hediger MA. Apical entry channels in calcium-transporting epithelia. News Physiol Sci. 2003 Aug; 18:158-63.
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Peng JB, Brown EM, Hediger MA. Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. J Physiol. 2003 Sep 15; 551(Pt 3):729-40.
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Hofer AM, Brown EM. Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol. 2003 Jul; 4(7):530-8.
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Kifor O, Kifor I, Moore FD, Butters RR, Brown EM. m-Calpain colocalizes with the calcium-sensing receptor (CaR) in caveolae in parathyroid cells and participates in degradation of the CaR. J Biol Chem. 2003 Aug 15; 278(33):31167-76.
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Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med. 2003 Jun; 9(6):796-800.
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Tfelt-Hansen J, Schwarz P, Brown EM, Chattopadhyay N. The calcium-sensing receptor in human disease. Front Biosci. 2003 May 1; 8:s377-90.
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Tfelt-Hansen J, MacLeod RJ, Chattopadhyay N, Yano S, Quinn S, Ren X, Terwilliger EF, Schwarz P, Brown EM. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. Am J Physiol Endocrinol Metab. 2003 Aug; 285(2):E329-37.
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Brown EM. Is the calcium receptor a molecular target for the actions of strontium on bone? Osteoporos Int. 2003; 14 Suppl 3:S25-34.
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Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb; 33(2):129-37.
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Kifor O, Moore FD, Delaney M, Garber J, Hendy GN, Butters R, Gao P, Cantor TL, Kifor I, Brown EM, Wysolmerski J. A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. J Clin Endocrinol Metab. 2003 Jan; 88(1):60-72.
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Brown EM. Pierre Janet and Félida Artificielle: multiple personality in a nineteenth-century guise. J Hist Behav Sci. 2003; 39(3):279-88.
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Yamaguchi T, Yamauchi M, Sugimoto T, Chauhan D, Anderson KC, Brown EM, Chihara K. The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation. Biochem Biophys Res Commun. 2002 Dec 13; 299(4):532-8.
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LaPlante JM, Falardeau J, Sun M, Kanazirska M, Brown EM, Slaugenhaupt SA, Vassilev PM. Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway. FEBS Lett. 2002 Dec 4; 532(1-2):183-7.
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Yamauchi M, Sugimoto T, Yamaguchi T, Yano S, Wang J, Bai M, Brown EM, Chihara K. Familial hypocalciuric hypercalcemia caused by an R648stop mutation in the calcium-sensing receptor gene. J Bone Miner Res. 2002 Dec; 17(12):2174-82.
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Brown EM. The pathophysiology of primary hyperparathyroidism. J Bone Miner Res. 2002 Nov; 17 Suppl 2:N24-9.
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Conigrave AD, Franks AH, Brown EM, Quinn SJ. L-amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? Eur J Clin Nutr. 2002 Nov; 56(11):1072-80.
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MacLeod RJ, Chattopadhyay N, Brown EM. PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation. Am J Physiol Endocrinol Metab. 2003 Feb; 284(2):E435-42.
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Imanishi Y, Hall C, Sablosky M, Brown EM, Arnold A. A new method for in vivo analysis of parathyroid hormone-calcium set point in mice. J Bone Miner Res. 2002 Sep; 17(9):1656-61.
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Chattopadhyay N, MacLeod RJ, Tfelt-Hansen J, Brown EM. 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E219-27.
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Zhang Z, Qiu W, Quinn SJ, Conigrave AD, Brown EM, Bai M. Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function. J Biol Chem. 2002 Sep 13; 277(37):33727-35.
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Nearing J, Betka M, Quinn S, Hentschel H, Elger M, Baum M, Bai M, Chattopadyhay N, Brown EM, Hebert SC, Harris HW. Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish. Proc Natl Acad Sci U S A. 2002 Jul 9; 99(14):9231-6.
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Kifor O, Kifor I, Brown EM. Signal transduction in the parathyroid. Curr Opin Nephrol Hypertens. 2002 Jul; 11(4):397-402.
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Chattopadhyay N, Tfelt-Hansen J, Brown EM. PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells. Brain Res Mol Brain Res. 2002 Jun 15; 102(1-2):73-82.
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D'Souza-Li L, Yang B, Canaff L, Bai M, Hanley DA, Bastepe M, Salisbury SR, Brown EM, Cole DE, Hendy GN. Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia. J Clin Endocrinol Metab. 2002 Mar; 87(3):1309-18.
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Bradbury RA, Cropley J, Kifor O, Lovicu FJ, de Iongh RU, Kable E, Brown EM, Seely EW, Peat BB, Conigrave AD. Localization of the extracellular Ca(2+)-sensing receptor in the human placenta. Placenta. 2002 Feb-Mar; 23(2-3):192-200.
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Brown EM. The calcium-sensing receptor (CaR) and its disorders. Hormones (Athens). 2002 Jan-Mar; 1(1):10-21.
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Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Brown EM. Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells. Am J Physiol Endocrinol Metab. 2001 Dec; 281(6):E1267-74.
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Vassilev PM, Peng JB, Hediger MA, Brown EM. Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2. J Membr Biol. 2001 Nov 15; 184(2):113-20.
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Caroppo R, Gerbino A, Debellis L, Kifor O, Soybel DI, Brown EM, Hofer AM, Curci S. Asymmetrical, agonist-induced fluctuations in local extracellular [Ca(2+)] in intact polarized epithelia. EMBO J. 2001 Nov 15; 20(22):6316-26.
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Lienhardt A, Bai M, Lagarde JP, Rigaud M, Zhang Z, Jiang Y, Kottler ML, Brown EM, Garabédian M. Activating mutations of the calcium-sensing receptor: management of hypocalcemia. J Clin Endocrinol Metab. 2001 Nov; 86(11):5313-23.
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Chattopadhyay N, Brown EM. Retinoic acid receptors are expressed in human primary astrocytes and their agonists inhibit parathyroid hormone-related peptide expression and secretion. Brain Res Mol Brain Res. 2001 Aug 15; 92(1-2):172-6.
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Peng JB, Brown EM, Hediger MA. Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics. 2001 Aug; 76(1-3):99-109.
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Hjälm G, MacLeod RJ, Kifor O, Chattopadhyay N, Brown EM. Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. J Biol Chem. 2001 Sep 14; 276(37):34880-7.
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Imanishi Y, Hosokawa Y, Yoshimoto K, Schipani E, Mallya S, Papanikolaou A, Kifor O, Tokura T, Sablosky M, Ledgard F, Gronowicz G, Wang TC, Schmidt EV, Hall C, Brown EM, Bronson R, Arnold A. Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice. J Clin Invest. 2001 May; 107(9):1093-102.
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Chen XZ, Segal Y, Basora N, Guo L, Peng JB, Babakhanlou H, Vassilev PM, Brown EM, Hediger MA, Zhou J. Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. Biochem Biophys Res Commun. 2001 Apr 20; 282(5):1251-6.
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Peng JB, Zhuang L, Berger UV, Adam RM, Williams BJ, Brown EM, Hediger MA, Freeman MR. CaT1 expression correlates with tumor grade in prostate cancer. Biochem Biophys Res Commun. 2001 Apr 6; 282(3):729-34.
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Vassilev PM, Guo L, Chen XZ, Segal Y, Peng JB, Basora N, Babakhanlou H, Cruger G, Kanazirska M. Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease. Biochem Biophys Res Commun. 2001 Mar 23; 282(1):341-50.
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Chattopadhyay N, Butters RR, Brown EM. Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells. Brain Res Mol Brain Res. 2001 Feb 19; 87(1):100-8.
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Yamaguchi T, Chattopadhyay N, Kifor O, Ye C, Vassilev PM, Sanders JL, Brown EM. Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line. Am J Physiol Cell Physiol. 2001 Feb; 280(2):C382-93.
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Kifor O, MacLeod RJ, Diaz R, Bai M, Yamaguchi T, Yao T, Kifor I, Brown EM. Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. Am J Physiol Renal Physiol. 2001 Feb; 280(2):F291-302.
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Vassilev PM, Peng JB, Johnson J, Hediger MA, Brown EM. Inhibition of CaT1 channel activity by a noncompetitive IP3 antagonist. Biochem Biophys Res Commun. 2001 Jan 12; 280(1):145-50.
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Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev. 2001 Jan; 81(1):239-297.
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Yamaguchi T, Chattopadhyay N, Kifor O, Sanders JL, Brown EM. Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line. Biochem Biophys Res Commun. 2000 Dec 20; 279(2):363-8.
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Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Butters RR, Brown EM. Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology. 2000 Dec; 141(12):4357-64.
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Cetani F, Picone A, Cerrai P, Vignali E, Borsari S, Pardi E, Viacava P, Naccarato AG, Miccoli P, Kifor O, Brown EM, Pinchera A, Marcocci C. Parathyroid expression of calcium-sensing receptor protein and in vivo parathyroid hormone-Ca(2+) set-point in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2000 Dec; 85(12):4789-94.
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Murphey ED, Chattopadhyay N, Bai M, Kifor O, Harper D, Traber DL, Hawkins HK, Brown EM, Klein GL. Up-regulation of the parathyroid calcium-sensing receptor after burn injury in sheep: a potential contributory factor to postburn hypocalcemia. Crit Care Med. 2000 Dec; 28(12):3885-90.
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Peng JB, Chen XZ, Berger UV, Weremowicz S, Morton CC, Vassilev PM, Brown EM, Hediger MA. Human calcium transport protein CaT1. Biochem Biophys Res Commun. 2000 Nov 19; 278(2):326-32.
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Zhang Z, Sun S, Quinn SJ, Brown EM, Bai M. The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions. J Biol Chem. 2001 Feb 16; 276(7):5316-22.
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Brown EM. Calcium receptor and regulation of parathyroid hormone secretion. Rev Endocr Metab Disord. 2000 Nov; 1(4):307-15.
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Moran RA, Brown EM, Bawden JW. Immunohistochemical localization of Galphaq, PLCbeta, Galphai1-2, PKA, and the endothelin B and extracellular Ca2+-sensing receptors during early amelogenesis. J Dent Res. 2000 Nov; 79(11):1896-901.
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Conigrave AD, Quinn SJ, Brown EM. Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca(2+) sensing receptor. Trends Pharmacol Sci. 2000 Oct; 21(10):401-7.
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Ye C, Chattopadhyay N, Brown EM, Vassilev PM. Defective extracellular calcium (Ca(o))-sensing receptor (CaR)-mediated stimulation of a Ca(2+)-activated potassium channel in glioblastoma cells transfected with a dominant negative CaR. Brain Res Mol Brain Res. 2000 Sep 15; 80(2):177-87.
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Peng JB, Chen XZ, Berger UV, Vassilev PM, Brown EM, Hediger MA. A rat kidney-specific calcium transporter in the distal nephron. J Biol Chem. 2000 Sep 8; 275(36):28186-94.
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Brown EM. Familial hypocalciuric hypercalcemia and other disorders with resistance to extracellular calcium. Endocrinol Metab Clin North Am. 2000 Sep; 29(3):503-22.
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Chattopadhyay N, Evliyaoglu C, Heese O, Carroll R, Sanders J, Black P, Brown EM. Regulation of secretion of PTHrP by Ca(2+)-sensing receptor in human astrocytes, astrocytomas, and meningiomas. Am J Physiol Cell Physiol. 2000 Sep; 279(3):C691-9.
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Ye CP, Yamaguchi T, Chattopadhyay N, Sanders JL, Vassilev PM, Brown EM. Extracellular calcium-sensing-receptor (CaR)-mediated opening of an outward K(+) channel in murine MC3T3-E1 osteoblastic cells: evidence for expression of a functional CaR. Bone. 2000 Jul; 27(1):21-7.
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Hofer AM, Curci S, Doble MA, Brown EM, Soybel DI. Intercellular communication mediated by the extracellular calcium-sensing receptor. Nat Cell Biol. 2000 Jul; 2(7):392-8.
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Chattopadhyay N, Singh DP, Heese O, Godbole MM, Sinohara T, Black PM, Brown EM. Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis. J Neurosci Res. 2000 Jul 1; 61(1):67-74.
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Chattopadhyay N, Brown EM. Cellular "sensing" of extracellular calcium (Ca(2+)(o)): emerging roles in regulating diverse physiological functions. Cell Signal. 2000 Jun; 12(6):361-6.
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Schwarz P, Larsen NE, Lønborg Friis IM, Lillquist K, Brown EM, Gammeltoft S. Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism associated with mutations in the human Ca2+-sensing receptor gene in three Danish families. Scand J Clin Lab Invest. 2000 May; 60(3):221-7.
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Carling T, Szabo E, Bai M, Ridefelt P, Westin G, Gustavsson P, Trivedi S, Hellman P, Brown EM, Dahl N, Rastad J. Familial hypercalcemia and hypercalciuria caused by a novel mutation in the cytoplasmic tail of the calcium receptor. J Clin Endocrinol Metab. 2000 May; 85(5):2042-7.
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Yamaguchi T, Ye C, Chattopadhyay N, Sanders JL, Vassilev PM, Brown EM. Enhanced expression of extracellular calcium sensing receptor in monocyte-differentiated versus undifferentiated HL-60 cells: potential role in regulation of a nonselective cation channel. Calcif Tissue Int. 2000 May; 66(5):375-82.
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Olszak IT, Poznansky MC, Evans RH, Olson D, Kos C, Pollak MR, Brown EM, Scadden DT. Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo. J Clin Invest. 2000 May; 105(9):1299-305.
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Conigrave AD, Quinn SJ, Brown EM. L-amino acid sensing by the extracellular Ca2+-sensing receptor. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4814-9.
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Lienhardt A, Garabédian M, Bai M, Sinding C, Zhang Z, Lagarde JP, Boulesteix J, Rigaud M, Brown EM, Kottler ML. A large homozygous or heterozygous in-frame deletion within the calcium-sensing receptor's carboxylterminal cytoplasmic tail that causes autosomal dominant hypocalcemia. J Clin Endocrinol Metab. 2000 Apr; 85(4):1695-702.
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Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Brown EM. Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy. Biochem Biophys Res Commun. 2000 Mar 16; 269(2):427-32.
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Haden ST, Brown EM, Hurwitz S, Scott J, El-Hajj Fuleihan G. The effects of age and gender on parathyroid hormone dynamics. Clin Endocrinol (Oxf). 2000 Mar; 52(3):329-38.
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Yarden N, Lavelin I, Genina O, Hurwitz S, Diaz R, Brown EM, Pines M. Expression of calcium-sensing receptor gene by avian parathyroid gland in vivo: relationship to plasma calcium. Gen Comp Endocrinol. 2000 Feb; 117(2):173-81.
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Brown EM. The extracellular Ca2+-sensing receptor: central mediator of systemic calcium homeostasis. Annu Rev Nutr. 2000; 20:507-33.
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Brown EM. G protein-coupled, extracellular Ca2+ (Ca2+(o))-sensing receptor enables Ca2+(o) to function as a versatile extracellular first messenger. Cell Biochem Biophys. 2000; 33(1):63-95.
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Yamaguchi T, Chattopadhyay N, Brown EM. G protein-coupled extracellular Ca2+ (Ca2+o)-sensing receptor (CaR): roles in cell signaling and control of diverse cellular functions. Adv Pharmacol. 2000; 47:209-53.
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Chattopadhyay N, Ye CP, Yamaguchi T, Kerner R, Vassilev PM, Brown EM. Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells. Brain Res. 1999 Dec 18; 851(1-2):116-24.
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Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y, Brown EM, Reeders ST, Hediger MA, Zhou J. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature. 1999 Sep 23; 401(6751):383-6.
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Gherman RB, Bowen E, Eggleston MK, Teague KE, Sayles T, Brown EM, Pollak MR. Successful pregnancy outcome in a woman with a gain-of-function mutation of the calcium-sensing receptor. A case report. J Reprod Med. 1999 Aug; 44(8):745-7.
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Chattopadhyay N, Ye C, Yamaguchi T, Nakai M, Kifor O, Vassilev PM, Nishimura RN, Brown EM. The extracellular calcium-sensing receptor is expressed in rat microglia and modulates an outward K+ channel. J Neurochem. 1999 May; 72(5):1915-22.
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Bai M, Trivedi S, Kifor O, Quinn SJ, Brown EM. Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2834-9.
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Chattopadhyay N, Ye CP, Yamaguchi T, Vassilev PM, Brown EM. Evidence for extracellular calcium-sensing receptor mediated opening of an outward K+ channel in a human astrocytoma cell line (U87). Glia. 1999 Mar; 26(1):64-72.
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Brown EM. Physiology and pathophysiology of the extracellular calcium-sensing receptor. Am J Med. 1999 Feb; 106(2):238-53.
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Porter L, Conlin PR, Scott J, Brown EM, El-Hajj Fuleihan G. Calcium modulation of the renin-aldosterone axis. J Endocrinol Invest. 1999 Feb; 22(2):115-21.
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Haden ST, Brown EM, Stoll AL, Scott J, Fuleihan GE. The effect of lithium on calcium-induced changes in adrenocorticotrophin levels. J Clin Endocrinol Metab. 1999 Jan; 84(1):198-200.
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Cheng I, Qureshi I, Chattopadhyay N, Qureshi A, Butters RR, Hall AE, Cima RR, Rogers KV, Hebert SC, Geibel JP, Brown EM, Soybel DI. Expression of an extracellular calcium-sensing receptor in rat stomach. Gastroenterology. 1999 Jan; 116(1):118-26.
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Brown EM, Vassilev PM, Quinn S, Hebert SC. G-protein-coupled, extracellular Ca(2+)-sensing receptor: a versatile regulator of diverse cellular functions. Vitam Horm. 1999; 55:1-71.
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Chattopadhyay N, Ye CP, Yamaguchi T, Kifor O, Vassilev PM, Nishimura R, Brown EM. Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel. Glia. 1998 Dec; 24(4):449-58.
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Yamaguchi T, Chattopadhyay N, Kifor O, Butters RR, Sugimoto T, Brown EM. Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells. J Bone Miner Res. 1998 Oct; 13(10):1530-8.
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Bai M, Trivedi S, Brown EM. Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells. J Biol Chem. 1998 Sep 4; 273(36):23605-10.
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Yamaguchi T, Kifor O, Chattopadhyay N, Bai M, Brown EM. Extracellular calcium (Ca2+o)-sensing receptor in a mouse monocyte-macrophage cell line (J774): potential mediator of the actions of Ca2+o on the function of J774 cells. J Bone Miner Res. 1998 Sep; 13(9):1390-7.
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Kifor O, Diaz R, Butters R, Kifor I, Brown EM. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem. 1998 Aug 21; 273(34):21708-13.
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Lin KI, Chattopadhyay N, Bai M, Alvarez R, Dang CV, Baraban JM, Brown EM, Ratan RR. Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor. Biochem Biophys Res Commun. 1998 Aug 19; 249(2):325-31.
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Bai M, Trivedi S, Lane CR, Yang Y, Quinn SJ, Brown EM. Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release. J Biol Chem. 1998 Aug 14; 273(33):21267-75.
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Darè E, Kifor O, Brown EM, Weber G. Characterization of the phosphatidylinositol-specific phospholipase C isozymes present in the bovine parathyroid and in human kidney HEK293 cells stably transfected with the human parathyroid Ca2+-sensing receptor. J Mol Endocrinol. 1998 Aug; 21(1):7-17.
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Yamaguchi T, Chattopadhyay N, Kifor O, Brown EM. Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells. Endocrinology. 1998 Aug; 139(8):3561-8.
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el-Hajj Fuleihan G, Seifter J, Scott J, Brown EM. Calcium-regulated renal calcium handling in healthy men: relationship to sodium handling. J Clin Endocrinol Metab. 1998 Jul; 83(7):2366-72.
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Watanabe T, Bai M, Lane CR, Matsumoto S, Minamitani K, Minagawa M, Niimi H, Brown EM, Yasuda T. Familial hypoparathyroidism: identification of a novel gain of function mutation in transmembrane domain 5 of the calcium-sensing receptor. J Clin Endocrinol Metab. 1998 Jul; 83(7):2497-502.
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Ward DT, Brown EM, Harris HW. Disulfide bonds in the extracellular calcium-polyvalent cation-sensing receptor correlate with dimer formation and its response to divalent cations in vitro. J Biol Chem. 1998 Jun 5; 273(23):14476-83.
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Schwarz P, Madsen JC, Rasmussen AQ, Transbøl I, Brown EM. Evidence for a role of intracellular stored parathyroid hormone in producing hysteresis of the PTH-calcium relationship in normal humans. Clin Endocrinol (Oxf). 1998 Jun; 48(6):725-32.
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Yamaguchi T, Olozak I, Chattopadhyay N, Butters RR, Kifor O, Scadden DT, Brown EM. Expression of extracellular calcium (Ca2+o)-sensing receptor in human peripheral blood monocytes. Biochem Biophys Res Commun. 1998 May 19; 246(2):501-6.
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Sands JM, Flores FX, Kato A, Baum MA, Brown EM, Ward DT, Hebert SC, Harris HW. Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats. Am J Physiol. 1998 May; 274(5 Pt 2):F978-85.
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Bradbury RA, Sunn KL, Crossley M, Bai M, Brown EM, Delbridge L, Conigrave AD. Expression of the parathyroid Ca(2+)-sensing receptor in cytotrophoblasts from human term placenta. J Endocrinol. 1998 Mar; 156(3):425-30.
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Riccardi D, Hall AE, Chattopadhyay N, Xu JZ, Brown EM, Hebert SC. Localization of the extracellular Ca2+/polyvalent cation-sensing protein in rat kidney. Am J Physiol. 1998 Mar; 274(3 Pt 2):F611-22.
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Yamaguchi T, Kifor O, Chattopadhyay N, Brown EM. Expression of extracellular calcium (Ca2 + o)-sensing receptor in the clonal osteoblast-like cell lines, UMR-106 and SAOS-2. Biochem Biophys Res Commun. 1998 Feb 24; 243(3):753-7.
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Cheng I, Klingensmith ME, Chattopadhyay N, Kifor O, Butters RR, Soybel DI, Brown EM. Identification and localization of the extracellular calcium-sensing receptor in human breast. J Clin Endocrinol Metab. 1998 Feb; 83(2):703-7.
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Brown EM, Chattopadhyay N, Vassilev PM, Hebert SC. The calcium-sensing receptor (CaR) permits Ca2+ to function as a versatile extracellular first messenger. Recent Prog Horm Res. 1998; 53:257-80; discussion 280-1.
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Chattopadhyay N, Cheng I, Rogers K, Riccardi D, Hall A, Diaz R, Hebert SC, Soybel DI, Brown EM. Identification and localization of extracellular Ca(2+)-sensing receptor in rat intestine. Am J Physiol. 1998 Jan; 274(1 Pt 1):G122-30.
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Brown EM, Pollak M, Hebert SC. The extracellular calcium-sensing receptor: its role in health and disease. Annu Rev Med. 1998; 49:15-29.
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House MG, Kohlmeier L, Chattopadhyay N, Kifor O, Yamaguchi T, Leboff MS, Glowacki J, Brown EM. Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells. J Bone Miner Res. 1997 Dec; 12(12):1959-70.
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Cima RR, Cheng I, Klingensmith ME, Chattopadhyay N, Kifor O, Hebert SC, Brown EM, Soybel DI. Identification and functional assay of an extracellular calcium-sensing receptor in Necturus gastric mucosa. Am J Physiol. 1997 Nov; 273(5 Pt 1):G1051-60.
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Brown EM. Empirical antimicrobial therapy of mechanically ventilated patients with nosocomial pneumonia. J Antimicrob Chemother. 1997 Oct; 40(4):463-8.
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Zafarullah K, Brown EM, Kuivaniemi H, Tromp G, Sieron AL, Fertala A, Prockop DJ. Synthesis and conformational properties of a recombinant C-propeptide of human type III procollagen. Matrix Biol. 1997 Oct; 16(4):201-9.
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Nielsen PK, Rasmussen AK, Butters R, Feldt-Rasmussen U, Bendtzen K, Diaz R, Brown EM, Olgaard K. Inhibition of PTH secretion by interleukin-1 beta in bovine parathyroid glands in vitro is associated with an up-regulation of the calcium-sensing receptor mRNA. Biochem Biophys Res Commun. 1997 Sep 29; 238(3):880-5.
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Diaz R, Hurwitz S, Chattopadhyay N, Pines M, Yang Y, Kifor O, Einat MS, Butters R, Hebert SC, Brown EM. Cloning, expression, and tissue localization of the calcium-sensing receptor in chicken (Gallus domesticus). Am J Physiol. 1997 Sep; 273(3 Pt 2):R1008-16.
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Chattopadhyay N, Vassilev PM, Brown EM. Calcium-sensing receptor: roles in and beyond systemic calcium homeostasis. Biol Chem. 1997 Aug; 378(8):759-68.
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Autry CP, Kifor O, Brown EM, Fuller FH, Rogers KV, Halloran BP. Ca2+ receptor mRNA and protein increase in the rat parathyroid gland with advancing age. J Endocrinol. 1997 Jun; 153(3):437-44.
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Chattopadhyay N, Legradi G, Bai M, Kifor O, Ye C, Vassilev PM, Brown EM, Lechan RM. Calcium-sensing receptor in the rat hippocampus: a developmental study. Brain Res Dev Brain Res. 1997 May 20; 100(1):13-21.
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Vassilev PM, Mitchel J, Vassilev M, Kanazirska M, Brown EM. Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft. Biophys J. 1997 May; 72(5):2103-16.
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Kifor O, Diaz R, Butters R, Brown EM. The Ca2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells. J Bone Miner Res. 1997 May; 12(5):715-25.
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Chattopadhyay N, Ye C, Singh DP, Kifor O, Vassilev PM, Shinohara T, Chylack LT, Brown EM. Expression of extracellular calcium-sensing receptor by human lens epithelial cells. Biochem Biophys Res Commun. 1997 Apr 28; 233(3):801-5.
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Bai M, Janicic N, Trivedi S, Quinn SJ, Cole DE, Brown EM, Hendy GN. Markedly reduced activity of mutant calcium-sensing receptor with an inserted Alu element from a kindred with familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. J Clin Invest. 1997 Apr 15; 99(8):1917-25.
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Vassilev PM, Ho-Pao CL, Kanazirska MP, Ye C, Hong K, Seidman CE, Seidman JG, Brown EM. Cao-sensing receptor (CaR)-mediated activation of K+ channels is blunted in CaR gene-deficient mouse neurons. Neuroreport. 1997 Apr 14; 8(6):1411-6.
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Butters RR, Chattopadhyay N, Nielsen P, Smith CP, Mithal A, Kifor O, Bai M, Quinn S, Goldsmith P, Hurwitz S, Krapcho K, Busby J, Brown EM. Cloning and characterization of a calcium-sensing receptor from the hypercalcemic New Zealand white rabbit reveals unaltered responsiveness to extracellular calcium. J Bone Miner Res. 1997 Apr; 12(4):568-79.
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Brown EM, Hebert SC. Calcium-receptor-regulated parathyroid and renal function. Bone. 1997 Apr; 20(4):303-9.
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Sands JM, Naruse M, Baum M, Jo I, Hebert SC, Brown EM, Harris HW. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest. 1997 Mar 15; 99(6):1399-405.
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Kállay E, Kifor O, Chattopadhyay N, Brown EM, Bischof MG, Peterlik M, Cross HS. Calcium-dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells: a role for a luminal extracellular calcium-sensing receptor. Biochem Biophys Res Commun. 1997 Mar 6; 232(1):80-3.
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Ye C, Ho-Pao CL, Kanazirska M, Quinn S, Rogers K, Seidman CE, Seidman JG, Brown EM, Vassilev PM. Amyloid-beta proteins activate Ca(2+)-permeable channels through calcium-sensing receptors. J Neurosci Res. 1997 Mar 1; 47(5):547-54.
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Vassilev PM, Kanazirska MP, Ye C, Francis J, Hong K, Brown EM. A flickery block of a K+ channel mediated by extracellular Ca2+ and other agonists of the Ca2+-sensing receptors in dispersed bovine parathyroid cells. Biochem Biophys Res Commun. 1997 Jan 23; 230(3):616-23.
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Rogers KV, Dunn CK, Hebert SC, Brown EM. Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization. Brain Res. 1997 Jan 2; 744(1):47-56.
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Ye C, Ho-Pao CL, Kanazirska M, Quinn S, Seidman CE, Seidman JG, Brown EM, Vassilev PM. Deficient cation channel regulation in neurons from mice with targeted disruption of the extracellular Ca2+-sensing receptor gene. Brain Res Bull. 1997; 44(1):75-84.
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el-Hajj Fuleihan G, Klerman EB, Brown EN, Choe Y, Brown EM, Czeisler CA. The parathyroid hormone circadian rhythm is truly endogenous--a general clinical research center study. J Clin Endocrinol Metab. 1997 Jan; 82(1):281-6.
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Seely EW, Brown EM, DeMaggio DM, Weldon DK, Graves SW. A prospective study of calciotropic hormones in pregnancy and post partum: reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am J Obstet Gynecol. 1997 Jan; 176(1 Pt 1):214-7.
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Brown EM. Mutations in the calcium-sensing receptor and their clinical implications. Horm Res. 1997; 48(5):199-208.
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Hebert SC, Brown EM, Harris HW. Role of the Ca(2+)-sensing receptor in divalent mineral ion homeostasis. J Exp Biol. 1997 Jan; 200(Pt 2):295-302.
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Bai M, Pearce SH, Kifor O, Trivedi S, Stauffer UG, Thakker RV, Brown EM, Steinmann B. In vivo and in vitro characterization of neonatal hyperparathyroidism resulting from a de novo, heterozygous mutation in the Ca2+-sensing receptor gene: normal maternal calcium homeostasis as a cause of secondary hyperparathyroidism in familial benign hypocalciuric hypercalcemia. J Clin Invest. 1997 Jan 1; 99(1):88-96.
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Pearce SH, Bai M, Quinn SJ, Kifor O, Brown EM, Thakker RV. Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells. J Clin Invest. 1996 Oct 15; 98(8):1860-6.
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Pearce SH, Williamson C, Kifor O, Bai M, Coulthard MG, Davies M, Lewis-Barned N, McCredie D, Powell H, Kendall-Taylor P, Brown EM, Thakker RV. A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. N Engl J Med. 1996 Oct 10; 335(15):1115-22.
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Riccardi D, Lee WS, Lee K, Segre GV, Brown EM, Hebert SC. Localization of the extracellular Ca(2+)-sensing receptor and PTH/PTHrP receptor in rat kidney. Am J Physiol. 1996 Oct; 271(4 Pt 2):F951-6.
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Ye C, Rogers K, Bai M, Quinn SJ, Brown EM, Vassilev PM. Agonists of the Ca(2+)-sensing receptor (CaR) activate nonselective cation channels in HEK293 cells stably transfected with the human CaR. Biochem Biophys Res Commun. 1996 Sep 13; 226(2):572-9.
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Brown EM, Hebert SC. The First Annual Bayard D. Catherwood Memorial Lecture. Ca2+-receptor-mediated regulation of parathyroid and renal function. Am J Med Sci. 1996 Sep; 312(3):99-109.
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Chattopadhyay N, Baum M, Bai M, Riccardi D, Hebert SC, Harris HW, Brown EM. Ontogeny of the extracellular calcium-sensing receptor in rat kidney. Am J Physiol. 1996 Sep; 271(3 Pt 2):F736-43.
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Bai M, Quinn S, Trivedi S, Kifor O, Pearce SH, Pollak MR, Krapcho K, Hebert SC, Brown EM. Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor. J Biol Chem. 1996 Aug 9; 271(32):19537-45.
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Chattopadhyay N, Mithal A, Brown EM. The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocr Rev. 1996 Aug; 17(4):289-307.
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Ye C, Kanazirska M, Quinn S, Brown EM, Vassilev PM. Modulation by polycationic Ca(2+)-sensing receptor agonists of nonselective cation channels in rat hippocampal neurons. Biochem Biophys Res Commun. 1996 Jul 5; 224(1):271-80.
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Pearce SH, Brown EM. Disorders of calcium ion sensing. J Clin Endocrinol Metab. 1996 Jun; 81(6):2030-5.
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Emanuel RL, Adler GK, Kifor O, Quinn SJ, Fuller F, Krapcho K, Brown EM. Calcium-sensing receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line. Mol Endocrinol. 1996 May; 10(5):555-65.
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Pollak MR, Seidman CE, Brown EM. Three inherited disorders of calcium sensing. Medicine (Baltimore). 1996 May; 75(3):115-23.
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Brown EM, Hebert SC. A cloned extracellular Ca(2+)-sensing receptor: molecular mediator of the actions of extracellular Ca2+ on parathyroid and kidney cells? Kidney Int. 1996 Apr; 49(4):1042-6.
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Kifor O, Moore FD, Wang P, Goldstein M, Vassilev P, Kifor I, Hebert SC, Brown EM. Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab. 1996 Apr; 81(4):1598-606.
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Pearce SH, Brown EM. Calcium-sensing receptor mutations: insights into a structurally and functionally novel receptor. J Clin Endocrinol Metab. 1996 Apr; 81(4):1309-11.
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Fuleihan GE, Brown EM, Gleason R, Scott J, Adler GK. Calcium modulation of adrenocorticotropin levels in women--a clinical research center study. J Clin Endocrinol Metab. 1996 Mar; 81(3):932-6.
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Brown EM, Segre GV, Goldring SR. Serpentine receptors for parathyroid hormone, calcitonin and extracellular calcium ions. Baillieres Clin Endocrinol Metab. 1996 Jan; 10(1):123-61.
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Hebert SC, Pollak M, Riccardi D, Brown EM. A Ca(2+)-sensing receptor: from physiology to inherited disorders of calcium homeostasis. Adv Nephrol Necker Hosp. 1996; 25:245-55.
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Hebert SC, Brown EM. The scent of an ion: calcium-sensing and its roles in health and disease. Curr Opin Nephrol Hypertens. 1996 Jan; 5(1):45-53.
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Brown EM, Hebert SC. A cloned Ca(2+)-sensing receptor: a mediator of direct effects of extracellular Ca2+ on renal function? J Am Soc Nephrol. 1995 Dec; 6(6):1530-40.
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Brown EM, Vassilev PM, Hebert SC. Calcium ions as extracellular messengers. Cell. 1995 Dec 1; 83(5):679-82.
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Ho C, Conner DA, Pollak MR, Ladd DJ, Kifor O, Warren HB, Brown EM, Seidman JG, Seidman CE. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet. 1995 Dec; 11(4):389-94.
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Hosokawa Y, Pollak MR, Brown EM, Arnold A. Mutational analysis of the extracellular Ca(2+)-sensing receptor gene in human parathyroid tumors. J Clin Endocrinol Metab. 1995 Nov; 80(11):3107-10.
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Garrett JE, Tamir H, Kifor O, Simin RT, Rogers KV, Mithal A, Gagel RF, Brown EM. Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene. Endocrinology. 1995 Nov; 136(11):5202-11.
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Hebert SC, Brown EM. The extracellular calcium receptor. Curr Opin Cell Biol. 1995 Aug; 7(4):484-92.
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Brown EM, Pollak M, Chou YH, Seidman CE, Seidman JG, Hebert SC. Cloning and functional characterization of extracellular Ca(2+)-sensing receptors from parathyroid and kidney. Bone. 1995 Aug; 17(2 Suppl):7S-11S.
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Brown EM, Pollak M, Seidman CE, Seidman JG, Chou YH, Riccardi D, Hebert SC. Calcium-ion-sensing cell-surface receptors. N Engl J Med. 1995 Jul 27; 333(4):234-40.
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Brown AJ, Zhong M, Ritter C, Brown EM, Slatopolsky E. Loss of calcium responsiveness in cultured bovine parathyroid cells is associated with decreased calcium receptor expression. Biochem Biophys Res Commun. 1995 Jul 26; 212(3):861-7.
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Brown EM, Pollak M, Chou YH, Seidman CE, Seidman JG, Hebert SC. The cloning of extracellular Ca(2+)-sensing receptors from parathyroid and kidney: molecular mechanisms of extracellular Ca(2+)-sensing. J Nutr. 1995 Jul; 125(7 Suppl):1965S-1970S.
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Mithal A, Kifor O, Kifor I, Vassilev P, Butters R, Krapcho K, Simin R, Fuller F, Hebert SC, Brown EM. The reduced responsiveness of cultured bovine parathyroid cells to extracellular Ca2+ is associated with marked reduction in the expression of extracellular Ca(2+)-sensing receptor messenger ribonucleic acid and protein. Endocrinology. 1995 Jul; 136(7):3087-92.
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Garrett JE, Capuano IV, Hammerland LG, Hung BC, Brown EM, Hebert SC, Nemeth EF, Fuller F. Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J Biol Chem. 1995 May 26; 270(21):12919-25.
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Brown EM, Pollak M, Hebert SC. Molecular mechanisms underlying the sensing of extracellular Ca2+ by parathyroid and kidney cells. Eur J Endocrinol. 1995 May; 132(5):523-31.
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Chou YH, Pollak MR, Brandi ML, Toss G, Arnqvist H, Atkinson AB, Papapoulos SE, Marx S, Brown EM, Seidman JG, et al. Mutations in the human Ca(2+)-sensing-receptor gene that cause familial hypocalciuric hypercalcemia. Am J Hum Genet. 1995 May; 56(5):1075-9.
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Kanazirska MP, Vassilev PM, Ye CP, Francis JE, Brown EM. Intracellular Ca(2+)-activated K+ channels modulated by variations in extracellular Ca2+ in dispersed bovine parathyroid cells. Endocrinology. 1995 May; 136(5):2238-43.
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Brown EM, Pollak M, Hebert SC. Sensing of extracellular Ca2+ by parathyroid and kidney cells: cloning and characterization of an extracellular Ca(2+)-sensing receptor. Am J Kidney Dis. 1995 Mar; 25(3):506-13.
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Rogers KV, Dunn CK, Conklin RL, Hadfield S, Petty BA, Brown EM, Hebert SC, Nemeth EF, Fox J. Calcium receptor messenger ribonucleic acid levels in the parathyroid glands and kidney of vitamin D-deficient rats are not regulated by plasma calcium or 1,25-dihydroxyvitamin D3. Endocrinology. 1995 Feb; 136(2):499-504.
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Riccardi D, Park J, Lee WS, Gamba G, Brown EM, Hebert SC. Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci U S A. 1995 Jan 3; 92(1):131-5.
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Fuleihan GE, Gundberg CM, Gleason R, Brown EM, Stromski ME, Grant FD, Conlin PR. Racial differences in parathyroid hormone dynamics. J Clin Endocrinol Metab. 1994 Dec; 79(6):1642-7.
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Pollak MR, Brown EM, Estep HL, McLaine PN, Kifor O, Park J, Hebert SC, Seidman CE, Seidman JG. Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation. Nat Genet. 1994 Nov; 8(3):303-7.
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Rubin LP, Kifor O, Hua J, Brown EM, Torday JS. Parathyroid hormone (PTH) and PTH-related protein stimulate surfactant phospholipid synthesis in rat fetal lung, apparently by a mesenchymal-epithelial mechanism. Biochim Biophys Acta. 1994 Aug 11; 1223(1):91-100.
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Pollak MR, Chou YH, Marx SJ, Steinmann B, Cole DE, Brandi ML, Papapoulos SE, Menko FH, Hendy GN, Brown EM, et al. Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype. J Clin Invest. 1994 Mar; 93(3):1108-12.
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Brown EM, Pollak M, Riccardi D, Hebert SC. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from parathyroid and kidney: new insights into the physiology and pathophysiology of calcium metabolism. Nephrol Dial Transplant. 1994; 9(12):1703-6.
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Pollak MR, Brown EM, Chou YH, Hebert SC, Marx SJ, Steinmann B, Levi T, Seidman CE, Seidman JG. Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell. 1993 Dec 31; 75(7):1297-303.
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Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature. 1993 Dec 9; 366(6455):575-80.
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Brown EM. Mechanisms underlying the regulation of parathyroid hormone secretion in vivo and in vitro. Curr Opin Nephrol Hypertens. 1993 Jul; 2(4):541-51.
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Rivkees SA, el-Hajj-Fuleihan G, Brown EM, Crawford JD. Tertiary hyperparathyroidism during high phosphate therapy of familial hypophosphatemic rickets. J Clin Endocrinol Metab. 1992 Dec; 75(6):1514-8.
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Kifor O, Kifor I, Brown EM. Effects of high extracellular calcium concentrations on phosphoinositide turnover and inositol phosphate metabolism in dispersed bovine parathyroid cells. J Bone Miner Res. 1992 Nov; 7(11):1327-36.
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Grant FD, Mandel SJ, Brown EM, Williams GH, Seely EW. Interrelationships between the renin-angiotensin-aldosterone and calcium homeostatic systems. J Clin Endocrinol Metab. 1992 Oct; 75(4):988-92.
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el-Hajj Fuleihan G, Brown EM, Curtis K, Berger MJ, Berger BM, Gleason R, LeBoff MS. Effect of sequential and daily continuous hormone replacement therapy on indexes of mineral metabolism. Arch Intern Med. 1992 Sep; 152(9):1904-9.
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Katz CL, Butters RR, Chen CJ, Brown EM. Structure-function relationships for the effects of various aminoglycoside antibiotics on dispersed bovine parathyroid cells. Endocrinology. 1992 Aug; 131(2):903-10.
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Chou YH, Brown EM, Levi T, Crowe G, Atkinson AB, Arnqvist HJ, Toss G, Fuleihan GE, Seidman JG, Seidman CE. The gene responsible for familial hypocalciuric hypercalcemia maps to chromosome 3q in four unrelated families. Nat Genet. 1992 Jul; 1(4):295-300.
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Seely EW, Wood RJ, Brown EM, Graves SW. Lower serum ionized calcium and abnormal calciotropic hormone levels in preeclampsia. J Clin Endocrinol Metab. 1992 Jun; 74(6):1436-40.
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Brown EM, Butters R, Katz C, Kifor O, Fuleihan GE. A comparison of the effects of concanavalin-A and tetradecanoylphorbol acetate on the modulation of parathyroid function by extracellular calcium and neomycin in dispersed bovine parathyroid cells. Endocrinology. 1992 Jun; 130(6):3143-51.
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Brown EM, Katz C, Butters R, Kifor O. Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells. J Bone Miner Res. 1991 Nov; 6(11):1217-25.
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Chen JM, Kung CE, Feairheller SH, Brown EM. An energetic evaluation of a "Smith" collagen microfibril model. J Protein Chem. 1991 Oct; 10(5):535-52.
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Fajtova VT, Quinn SJ, Brown EM. Cytosolic calcium responses of single rMTC 44-2 cells to stimulation with external calcium and potassium. Am J Physiol. 1991 Jul; 261(1 Pt 1):E151-8.
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el-Hajj Fuleihan G, Katz C, Kifor O, Gleason R, Brown EM. Effects of the lectin concanavalin-A on the regulation of second messengers and parathyroid hormone release by extracellular Ca2+ in bovine parathyroid cells. Endocrinology. 1991 Jun; 128(6):2931-6.
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Brown EM, Butters R, Katz C, Kifor O. Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells. Endocrinology. 1991 Jun; 128(6):3047-54.
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Mathias RS, Brown EM. Divalent cations modulate PTH-dependent 3',5'-cyclic adenosine monophosphate production in renal proximal tubular cells. Endocrinology. 1991 Jun; 128(6):3005-12.
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Brown EM. Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers. Physiol Rev. 1991 Apr; 71(2):371-411.
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Gundberg CM, Grant FD, Conlin PR, Chen CJ, Brown EM, Johnson PJ, LeBoff MS. Acute changes in serum osteocalcin during induced hypocalcemia in humans. J Clin Endocrinol Metab. 1991 Feb; 72(2):438-43.
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Rubin LP, Posillico JT, Anast CS, Brown EM. Circulating levels of biologically active and immunoreactive intact parathyroid hormone in human newborns. Pediatr Res. 1991 Feb; 29(2):201-7.
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Rabadjija L, Brown EM, Swartz SL, Chen CJ, Goldhaber P. H(+)-stimulated release of prostaglandin E2 and cyclic adenosine 3',5'-monophosphoric acid and their relationship to bone resorption in neonatal mouse calvaria cultures. Bone Miner. 1990 Dec; 11(3):295-304.
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Kifor O, Congo D, Brown EM. Phorbol esters modulate the high Ca2(+)-stimulated accumulation of inositol phosphates in bovine parathyroid cells. J Bone Miner Res. 1990 Oct; 5(10):1003-11.
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Brown EM. A comparison of the effects of divalent and trivalent cations on parathyroid hormone release, 3',5'-cyclic-adenosine monophosphate accumulation, and the levels of inositol phosphates in bovine parathyroid cells. Endocrinology. 1990 Sep; 127(3):1064-71.
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Grant FD, Conlin PR, Brown EM. Rate and concentration dependence of parathyroid hormone dynamics during stepwise changes in serum ionized calcium in normal humans. J Clin Endocrinol Metab. 1990 Aug; 71(2):370-8.
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Leboff MS, Oetting M, Brown EM. Mechanisms underlying the stimulation of PTH release by GppNHp in permeabilized bovine parathyroid cells. J Bone Miner Res. 1990 Jul; 5(7):683-9.
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Chen CJ, Brown EM. The diltiazem analog TA-3090 mimics the actions of high extracellular Ca2+ on parathyroid function in dispersed bovine parathyroid cells. J Bone Miner Res. 1990 Jun; 5(6):581-7.
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Brown EM, Chen CJ, Kifor O, Leboff MS, el-Hajj G, Fajtova V, Rubin LT. Ca2(+)-sensing, second messengers, and the control of parathyroid hormone secretion. Cell Calcium. 1990 May; 11(5):333-7.
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el-Hajj Fuleihan G, Brown EM. Effect of the lectin concanavalin-A on calcium-regulated adenosine 3',5'-monophosphate accumulation in bovine parathyroid cells. Endocrinology. 1990 Apr; 126(4):1996-2002.
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Smith S, Swain J, Brown EM, Wyshak G, Albright T, Ravnikar VA, Schiff I. A preliminary report of the short-term effect of carbonated beverage consumption on calcium metabolism in normal women. Arch Intern Med. 1989 Nov; 149(11):2517-9.
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Warren HB, Lausen NC, Segre GV, el-Hajj G, Brown EM. Regulation of calciotropic hormones in vivo in the New Zealand white rabbit. Endocrinology. 1989 Nov; 125(5):2683-90.
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Brown EM. Fluoride and the therapy of osteoporosis. J Clin Endocrinol Metab. 1989 Nov; 69(5):929-31.
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el-Hajj Fuleihan G, Chen CJ, Rivkees SA, Marynick SP, Stock J, Pallotta JA, Brown EM. Calcium-dependent release of N-terminal fragments and intact immunoreactive parathyroid hormone by human pathological parathyroid tissue in vitro. J Clin Endocrinol Metab. 1989 Oct; 69(4):860-7.
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Jarvie KR, Booth G, Brown EM, Niznik HB. Glycoprotein nature of dopamine D1 receptors in the brain and parathyroid gland. Mol Pharmacol. 1989 Oct; 36(4):566-74.
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Conlin PR, Fajtova VT, Mortensen RM, LeBoff MS, Brown EM. Hysteresis in the relationship between serum ionized calcium and intact parathyroid hormone during recovery from induced hyper- and hypocalcemia in normal humans. J Clin Endocrinol Metab. 1989 Sep; 69(3):593-9.
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Niznik HB, Jarvie KR, Brown EM. Dopamine D1 receptors of the calf parathyroid gland: identification of a ligand binding subunit with lower apparent molecular weight but similar primary structure to neuronal D1-receptors. Biochemistry. 1989 Aug 22; 28(17):6925-30.
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Seely EW, Moore TJ, LeBoff MS, Brown EM. A single dose of lithium carbonate acutely elevates intact parathyroid hormone levels in humans. Acta Endocrinol (Copenh). 1989 Aug; 121(2):174-6.
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Ikeda K, Posillico JT, Boyle MB, Webb AC, Brown EM, Broadus AE. Microinjected Xenopus oocytes secrete mature, biologically active parathyroid hormone. Mol Endocrinol. 1989 Jul; 3(7):1084-9.
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Seely EW, LeBoff MS, Brown EM, Chen C, Posillico JT, Hollenberg NK, Williams GH. The calcium channel blocker diltiazem lowers serum parathyroid hormone levels in vivo and in vitro. J Clin Endocrinol Metab. 1989 Jun; 68(6):1007-12.
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Brown EM. Effects of phospholipids on the conformation of chicken high density lipoprotein. Poult Sci. 1989 Mar; 68(3):399-407.
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Brown EM, Chen CJ. Calcium, magnesium and the control of PTH secretion. Bone Miner. 1989 Mar; 5(3):249-57.
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Crigler JF, Glimcher MJ, Brown EM, Lian JB. In memory of Constantine Spiro Anast. Bone Miner. 1989 Mar; 5(3):iii-vii.
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Chen CJ, Barnett JV, Congo DA, Brown EM. Divalent cations suppress 3',5'-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotide-binding protein in cultured bovine parathyroid cells. Endocrinology. 1989 Jan; 124(1):233-9.
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Brown EM, Chen CJ, LeBoff MS, Kifor O, Oetting MH, el-Hajj G. Mechanisms underlying the inverse control of parathyroid hormone secretion by calcium. Soc Gen Physiol Ser. 1989; 44:251-68.
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Kifor O, Brown EM. Relationship between diacylglycerol levels and extracellular Ca2+ in dispersed bovine parathyroid cells. Endocrinology. 1988 Dec; 123(6):2723-9.
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Ikeda K, Weir EC, Mangin M, Dannies PS, Kinder B, Deftos LJ, Brown EM, Broadus AE. Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas. Mol Endocrinol. 1988 Dec; 2(12):1230-6.
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Brent GA, LeBoff MS, Seely EW, Conlin PR, Brown EM. Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans. J Clin Endocrinol Metab. 1988 Nov; 67(5):944-50.
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Davis OK, Hawkins DS, Rubin LP, Posillico JT, Brown EM, Schiff I. Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH. J Clin Endocrinol Metab. 1988 Oct; 67(4):850-2.
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Niznik HB, Fogel EL, Chen CJ, Congo D, Brown EM, Seeman P. Dopamine D1 receptors of the calf parathyroid gland: identification and characterization. Mol Pharmacol. 1988 Jul; 34(1):29-36.
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Chen CJ, Anast CS, Brown EM. Effects of fluoride on parathyroid hormone secretion and intracellular second messengers in bovine parathyroid cells. J Bone Miner Res. 1988 Jun; 3(3):279-88.
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Oetting M, LeBoff MS, Levy S, Swiston L, Preston J, Chen C, Brown EM. Permeabilization reveals classical stimulus-secretion coupling in bovine parathyroid cells. Endocrinology. 1987 Oct; 121(4):1571-6.
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Chen CJ, Anast CS, Brown EM. High osmolality: a potent parathyroid hormone secretogogue in dispersed parathyroid cells. Endocrinology. 1987 Sep; 121(3):958-64.
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Chen CJ, Anast CS, Posillico JT, Brown EM. Effects of extracellular calcium and magnesium on cytosolic calcium concentration in Fura-2-loaded bovine parathyroid cells. J Bone Miner Res. 1987 Aug; 2(4):319-27.
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Posillico JT, Wilson RE, Srikanta SS, Eisenbarth GS, Letarte M, Quackenbush EJ, Quaranta V, Kajaji S, Brown EM. Monoclonal antibody-mediated modulation of parathyroid hormone secretion by dispersed parathyroid cells. Arch Surg. 1987 Apr; 122(4):436-42.
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Brown EM, LeBoff MS, Oetting M, Posillico JT, Chen C. Secretory control in normal and abnormal parathyroid tissue. Recent Prog Horm Res. 1987; 43:337-82.
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Posillico JT, Srikanta S, Eisenbarth G, Quaranta V, Kajiji S, Brown EM. Binding of monoclonal antibody (4F2) to its cell surface antigen on dispersed adenomatous parathyroid cells raises cytosolic calcium and inhibits parathyroid hormone secretion. J Clin Endocrinol Metab. 1987 Jan; 64(1):43-50.
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Brown EM, Watson EJ, Thatcher JG, Koletsky R, Dawson-Hughes BF, Posillico JT, Shoback DM. Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration. Metabolism. 1987 Jan; 36(1):36-42.
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Posillico JT, Wortsman J, Srikanta S, Eisenbarth GS, Mallette LE, Brown EM. Parathyroid cell surface autoantibodies that inhibit parathyroid hormone secretion from dispersed human parathyroid cells. J Bone Miner Res. 1986 Oct; 1(5):475-83.
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Braley LM, Menachery AI, Brown EM, Williams GH. Comparative effect of angiotensin II, potassium, adrenocorticotropin, and cyclic adenosine 3',5'-monophosphate on cytosolic calcium in rat adrenal cells. Endocrinology. 1986 Sep; 119(3):1010-9.
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Wortsman J, Haddad JG, Posillico JT, Brown EM. Primary hyperparathyroidism with low serum 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab. 1986 Jun; 62(6):1305-8.
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LeBoff MS, Chang J, Henry M, Beaudoin D, Swiston L, Brown EM. Role of cytosolic calcium in the control of cAMP content by calcium in bovine parathyroid cells. Mol Cell Endocrinol. 1986 May; 45(2-3):127-35.
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Marx SJ, Lasker RD, Brown EM, Fitzpatrick LA, Sweezey NB, Goldbloom RB, Gillis DA, Cole DE. Secretory dysfunction in parathyroid cells from a neonate with severe primary hyperparathyroidism. J Clin Endocrinol Metab. 1986 Feb; 62(2):445-9.
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Brown EM, Leombruno R, Thatcher J, Burrowes M. The acute secretory response to alterations in extracellular calcium concentration and dopamine in perifused bovine parathyroid cells. Endocrinology. 1985 Mar; 116(3):1123-32.
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LeBoff MS, Shoback D, Brown EM, Thatcher J, Leombruno R, Beaudoin D, Henry M, Wilson R, Pallotta J, Marynick S, et al. Regulation of parathyroid hormone release and cytosolic calcium by extracellular calcium in dispersed and cultured bovine and pathological human parathyroid cells. J Clin Invest. 1985 Jan; 75(1):49-57.
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Brown EM, Swartz SL. Production of prostaglandins by dispersed cells and fragments from bovine parathyroid glands. Prostaglandins. 1985 Jan; 29(1):35-46.
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Shoback DM, Thatcher JG, Brown EM. Interaction of extracellular calcium and magnesium in the regulation of cytosolic calcium and PTH release in dispersed bovine parathyroid cells. Mol Cell Endocrinol. 1984 Dec; 38(2-3):179-86.
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Shoback DM, Brown EM. PTH release stimulated by high extracellular potassium is associated with a decrease in cytosolic calcium in bovine parathyroid cells. Biochem Biophys Res Commun. 1984 Sep 17; 123(2):684-90.
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Brown EM, Redgrave J, Thatcher J. Effect of the phorbol ester TPA on PTH secretion. Evidence for a role for protein kinase C in the control of PTH release. FEBS Lett. 1984 Sep 17; 175(1):72-5.
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Shoback DM, Brown EM. Forskolin increases cellular cyclic adenosine monophosphate content and parathyroid hormone release in dispersed bovine parathyroid cells. Metabolism. 1984 Jun; 33(6):509-14.
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Shoback DM, Thatcher J, Leombruno R, Brown EM. Relationship between parathyroid hormone secretion and cytosolic calcium concentration in dispersed bovine parathyroid cells. Proc Natl Acad Sci U S A. 1984 May; 81(10):3113-7.
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Brown EM, Thatcher JG, Watson EJ, Leombruno R. Extracellular calcium potentiates the inhibitory effects of magnesium on parathyroid function in dispersed bovine parathyroid cells. Metabolism. 1984 Feb; 33(2):171-6.
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Brown EM, Shoback DM. The relationship between PTH secretion and cytosolic calcium concentration in bovine parathyroid cells. Prog Clin Biol Res. 1984; 168:139-44.
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Brown EM, Watson EJ, Leombruno R, Underwood RH. Extracellular calcium is not necessary for acute, low calcium- or dopamine-stimulated PTH secretion in dispersed bovine parathyroid cells. Metabolism. 1983 Nov; 32(11):1038-44.
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Dawson-Hughes BF, Underwood RH, Brown EM. Ca-ATPase activity in bovine parathyroid cells. Metabolism. 1983 Sep; 32(9):874-80.
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Koletsky RJ, Brown EM, Williams GH. Calmodulin-like activity and calcium-dependent phosphodiesterase in purified cells of the rat zona glomerulosa and zona fasciculata. Endocrinology. 1983 Aug; 113(2):485-90.
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LeBoff MS, Rennke HG, Brown EM. Abnormal regulation of parathyroid cell secretion and proliferation in primary cultures of bovine parathyroid cells. Endocrinology. 1983 Jul; 113(1):277-84.
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Brown EM, Jones P, Adragna N. Effects of ouabain on [3H]ouabain binding, 86Rb uptake, cellular sodium and potassium, and parathyroid hormone secretion in dispersed bovine parathyroid cells. Endocrinology. 1983 Jul; 113(1):371-8.
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Gardner DG, Brown EM, Aurbach GD. Inhibition of parathyroid hormone release from dispersed bovine cells by ouabain. Metabolism. 1983 Apr; 32(4):355-8.
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Brown EM. Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue. J Clin Endocrinol Metab. 1983 Mar; 56(3):572-81.
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Brown EM. PTH secretion in vivo and in vitro. Regulation by calcium and other secretagogues. Miner Electrolyte Metab. 1982 Sep-Oct; 8(3-4):130-50.
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Brown EM, Thatcher JG. Adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase and the regulation of parathyroid hormone release by divalent cations and agents elevating cellular cAMP in dispersed bovine parathyroid cells. Endocrinology. 1982 Apr; 110(4):1374-80.
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Thatcher JG, Gardner DG, Brown EM. Adenosine 3',5'-monophosphate-dependent protein kinase in supernatants from dispersed bovine parathyroid cells. Endocrinology. 1982 Apr; 110(4):1367-73.
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Brown EM, Wilson RE, Eastman RC, Pallotta J, Marynick SP. Abnormal regulation of parathyroid hormone release by calcium in secondary hyperparathyroidism due to chronic renal failure. J Clin Endocrinol Metab. 1982 Jan; 54(1):172-9.
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Gardner DG, Brown EM, Aurbach GD. Sodium nitroprusside inhibition of parathyroid hormone release is not mediated through cyclic GMP. Metabolism. 1981 Dec; 30(12):1179-84.
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Brown EM, Adragna N, Gardner DG. Effect of potassium on PTH secretion from dispersed bovine parathyroid cells. J Clin Endocrinol Metab. 1981 Dec; 53(6):1304-6.
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Brown EM, Dawson-Hughes BF, Wilson RE, Adragna N. Calmodulin in dispersed human parathyroid cells. J Clin Endocrinol Metab. 1981 Nov; 53(5):1064-71.
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Gardner DG, Brown EM, Attie MF, Aurbach GD. Effects of prostaglandins on adenosine 3',5'-monophosphate content and adenylate cyclase activity in dispersed bovine parathyroid cells. Endocrinology. 1981 Nov; 109(5):1545-51.
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Brown EM, Wilson RE, Thatcher JG, Marynick SP. Abnormal calcium-regulated PTH release in normal parathyroid tissue from patients with adenoma. Am J Med. 1981 Oct; 71(4):565-70.
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Spiegel AM, Marx SJ, Brennan MF, Brown EM, Downs RW, Gardner DG, Attie MF, Aurbach GD. Parathyroid function after parathyroidectomy: evaluation by measurement of urinary cAMP. Clin Endocrinol (Oxf). 1981 Jul; 15(1):65-73.
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Brown EM. Relationship of 3',5'-adenosine monophosphate accumulation to parathyroid hormone release in dispersed cells from pathological human parathyroid tissue. J Clin Endocrinol Metab. 1981 May; 52(5):961-8.
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Brown EM. Lithium induces abnormal calcium-regulated PTH release in dispersed bovine parathyroid cells. J Clin Endocrinol Metab. 1981 May; 52(5):1046-8.
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Attie MF, Brown EM, Gardner DG, Spiegel AM, Aurbach GD. Characterization of the dopamine-responsive adenylate cyclase of bovine parathyroid cells and its relationship to parathyroid hormone secretion. Endocrinology. 1980 Dec; 107(6):1776-81.
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Brown EM. Calcium-regulated phosphodiesterase in bovine parathyroid cells. Endocrinology. 1980 Dec; 107(6):1998-2003.
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Brown EM. Histamine receptors on dispersed parathyroid cells from pathological human parathyroid tissue. J Clin Endocrinol Metab. 1980 Dec; 51(6):1325-9.
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Brown EM, Attie MF, Reen S, Gardner DG, Kebabian J, Aurbach GD. Characterization of dopaminergic receptors in dispersed bovine parathyroid cells. Mol Pharmacol. 1980 Nov; 18(3):335-40.
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Brennan MF, Brown EM. Prediction of in vivo function of human parathyroid tissue autografts by in vitro testing. World J Surg. 1980 Nov; 4(6):747-51.
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Gardner DG, Brown EM, Attie MF, Aurbach GD. Prostaglandin-mediated stimulation of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release in dispersed human parathyroid cells. J Clin Endocrinol Metab. 1980 Jul; 51(1):20-5.
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Marx SJ, Spiegel AM, Sharp ME, Brown EM, Gardner DG, Downs RW, Attie MF, Stock JL. Adenosine 3',5'-monophosphate response to parathyroid hormone: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. J Clin Endocrinol Metab. 1980 Mar; 50(3):546-8.
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Marx SJ, Stock JL, Attie MF, Downs RW, Gardner DG, Brown EM, Spiegel AM, Doppman JL, Brennan MF. Familial hypocalciuric hypercalcemia: recognition among patients referred after unsuccessful parathyroid exploration. Ann Intern Med. 1980 Mar; 92(3):351-6.
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Jacobowitz DM, Brown EM. Bovine parathyroid catecholamines: a chemical and histochemical study. Experientia. 1980 Jan 15; 36(1):115-6.
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Brown EM, Aurbach GD. Role of cyclic nucleotides in secretory mechanisms and actions of parathyroid hormone and calcitonin. Vitam Horm. 1980; 38:205-56.
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Brown EM, Gardner DG, Aurbach GD. Effects of the calcium ionophore A23187 on dispersed bovine parathyroid cells. Endocrinology. 1980 Jan; 106(1):133-8.
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Marx SJ, Spiegel AM, Brown EM, Downs RW, Attie MF, Stock JL, Levine MA, Aurbach GD. Urinary cyclic 3',5'-adenosine monophosphate (cAMP): an index of the action of parathyroid hormone on the kidney. Prog Biochem Pharmacol. 1980; 17:182-9.
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Brown EM, Krishnaprasad D, Smiler BG. Pancuronium for rapid induction technique for tracheal intubation. Can Anaesth Soc J. 1979 Nov; 26(6):489-91.
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Gardner DG, Brown EM, Aurbach GD. Inhibition of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release by sodium nitroprusside. Endocrinology. 1979 Aug; 105(2):360-6.
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Brown EM, Gardner DG, Brennan MF, Marx SJ, Spiegel AM, Attie MF, Downs RW, Doppman JL, Aurbach CD. Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells. Am J Med. 1979 Jun; 66(6):923-31.
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Brown EM, Broadus AE, Brennan MF, Gardner DG, Marx SJ, Spiegel AM, Downs RW, Attie M, Aurbach GD. Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism. J Clin Endocrinol Metab. 1979 Apr; 48(4):604-10.
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Brown EM, Brennan MF, Broadus AE, Marx SJ, Gardner DG, Spiegel AM, Downs RW, Attie MF, Aurbach GD. Human parathyroid autografts: comparison of function in vivo and in vitro. J Clin Endocrinol Metab. 1979 Apr; 48(4):648-54.
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Brown EM, Gardner DG, Windeck RA, Hurwitz S, Brennan MF, Aurbach GD. Beta-adrenergically stimulated adenosine 3',5'-monophosphate accumulation in and parathyroid hormone release from dispersed human parathyroid cells. J Clin Endocrinol Metab. 1979 Apr; 48(4):618-26.
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Doppman JL, Brown EM, Brennan MF, Spiegel A, Marx SJ, Aurbach GD. Angiographic ablation of parathyroid adenomas. Radiology. 1979 Mar; 130(3):577-82.
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Brennan MF, Brown EM, Spiegel AM, Marx SJ, Doppman JL, Jones DC, Aurbach GD. Autotransplantation of cryopreserved parathyroid tissue in man. Ann Surg. 1979 Feb; 189(2):139-42.
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Brown EM, Gardner DG, Windeck RA, Aurbach GD. Cholera toxin stimulates 3',5'-adenosine monophosphate accumulation and parathyroid hormone release from dispersed bovine parathyroid cells. Endocrinology. 1979 Jan; 104(1):218-25.
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Gardner DG, Brown EM, Windeck R, Aurbach GD. Prostaglandin F2alpha inhibits 3',3'-adenosine monophosphate accumulation and parathyroid hormone release from dispersed bovine parathyroid cells. Endocrinology. 1979 Jan; 104(1):1-7.
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Brown EM, Gardner DG, Windeck RA, Aurbach GD. Relationship of intracellular 3',5'-adenosine monophosphate accumulation to parathyroid hormone release from dispersed bovine parathyroid cells. Endocrinology. 1978 Dec; 103(6):2323-33.
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Marx SJ, Spiegel AM, Brown EM, Windeck R, Gardner DG, Downs RW, Attie M, Aurbach GD. Circulating parathyroid hormone activity: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. J Clin Endocrinol Metab. 1978 Dec; 47(6):1190-7.
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Marx SJ, Spiegel AM, Brown EM, Gardner DG, Downs RW, Attie M, Hamstra AJ, DeLuca HF. A familial syndrome of decrease in sensitivity to 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab. 1978 Dec; 47(6):1303-10.
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Windeck R, Brown EM, Gardner DG, Aurbach GD. Effect of gastrointestinal hormones on isolated bovine parathyroid cells. Endocrinology. 1978 Dec; 103(6):2020-6.
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Spiegel AM, Doppman JL, Marx SJ, Brennan MF, Brown EM, Downs RW, Gardner DG, Attie M, Aurbach GD. Preoperative localization of abnormal parathyroid: neck massage versus arteriography and selective venous sampling. Ann Intern Med. 1978 Dec; 89(6):935-6.
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Brennan MF, Brown EM, Marx SJ, Spiegel AM, Broadus AE, Doppman JL, Webber B, Aurbach GD. Recurrent hyperparathyroidism from an autotransplanted parathyroid adenoma. N Engl J Med. 1978 Nov 9; 299(19):1057-9.
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Spiegel AM, Marx SJ, Brennan MF, Brown EM, Koehler JO, Aurbach GD. Urinary cAMP excretion during surgery: an index of successful parathyroidectomy in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 1978 Sep; 47(3):537-42.
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Brown EM, Hurwitz SH, Aurbach GD. alpha-Adrenergic inhibition of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release from dispersed bovine parathyroid cells. Endocrinology. 1978 Sep; 103(3):893-9.
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Gardner DG, Brown EM, Windeck R, Aurbach GD. Prostaglandin E2 stimulation of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release in dispersed bovine parathyroid cells. Endocrinology. 1978 Aug; 103(2):577-82.
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Marx SJ, Spiegel AM, Brown EM, Koehler JO, Gardner DG, Brennan MF, Aurbach GD. Divalent cation metabolism. Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. Am J Med. 1978 Aug; 65(2):235-42.
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Brennan MF, Doppman JL, Marx SJ, Spiegel AM, Brown EM, Aurbach GD. Reoperative parathyroid surgery for persistent hyperparathyroidism. Surgery. 1978 Jun; 83(6):669-76.
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Brown EM, Brennan MF, Hurwitz S, Windeck R, Marx SJ, Spiegel AM, Koehler JO, Gardner DG, Aurbach GD. Dispersed cells prepared from human parathyroid glands: distinct calcium sensitivity of adenomas vs. primary hyperplasia. J Clin Endocrinol Metab. 1978 Feb; 46(2):267-75.
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Brown EM, Pazoles CJ, Creutz CE, Aurbach GD, Pollard HB. Role of anions in parathyroid hormone release from dispersed bovine parathyroid cells. Proc Natl Acad Sci U S A. 1978 Feb; 75(2):876-80.
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Brennan MF, Brown EM, Sears HF, Aurbach GD. Human parathyroid cryopreservation: in vitro testing of function by parathyroid hormone release. Ann Surg. 1978 Jan; 187(1):87-90.
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Brown EM, Carroll RJ, Aurbach GD. Dopaminergic stimulation of cyclic AMP accumulation and parathyroid hormone release from dispersed bovine parathyroid cells. Proc Natl Acad Sci U S A. 1977 Oct; 74(10):4210-3.
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Bilezikian JP, Spiegel AM, Brown EM, Aurbach GD. Identification and persistence of beta adrenergic receptors during maturation of the rat reticulocyte. Mol Pharmacol. 1977 Sep; 13(5):775-85.
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Brown EM, Hurwitz S, Aurbach GD. Beta-adrenergic stimulation of cyclic AMP content and parathyroid hormone release from isolated bovine parathyroid cells. Endocrinology. 1977 Jun; 100(6):1696-702.
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Brown EM, Hurwitz S, Woodard CJ, Aurbach GD. Direct identification of beta-adrenergic receptors on isolated bovine parathyroid cells. Endocrinology. 1977 Jun; 100(6):1703-9.
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Aurbach GD, Brown EM, Marx SJ. Receptors and cyclic nucleotides in secretion and action of parathyroid hormone. Calcif Tissue Res. 1977 May; 22 Suppl:117-26.
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Marx SJ, Spiegel AM, Brown EM, Aurbach GD. Family studies in patients with primary parathyroid hyperplasia. Am J Med. 1977 May; 62(5):698-706.
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Spiegel AM, Harrison HE, Marx SJ, Brown EM, Aurbach GD. Neonatal primary hyperparathyroidism with autosomal dominant inheritance. J Pediatr. 1977 Feb; 90(2):269-72.
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Pollard HB, Pazoles CJ, Creutz CE, Ramu A, Strott CA, Ray P, Brown EM, Aurbach GD, Tack-Goldman KM, Shulman NR. A role for anion transport in the regulation of release from chromaffin granules and exocytosis from cells. J Supramol Struct. 1977; 7(3-4):277-85.
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Brown EM, Hurwitz S, Aurbach GD. Preparation of viable isolated bovine parathyroid cells. Endocrinology. 1976 Dec; 99(6):1582-8.
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Spiegel AM, Brown EM, Aurbach GD. Inhibition of adenylate cyclase by arsenite and cadmium: evidence for a vicinal dithiol requirement. J Cyclic Nucleotide Res. 1976 Nov-Dec; 2(6):393-404.
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Brown EM, Gardner JD, Aurbach GD. Direct determination of ligand interactions with beta-adrenergic receptors on intact turkey erythrocytes: correlation of binding with biological activity. Endocrinology. 1976 Nov; 99(5):1370-6.
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Brown EM, Aurbach GD. Beta-Adrenergic receptor interactions. Characterization of iodohydroxybenzylpindolol as a specific ligand. J Biol Chem. 1976 Mar 10; 251(5):1232-8.
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Brown EM, Fedak SA, Woodard CJ, Aurbach GD. Beta-Adrenergic receptor interactions. Direct comparison of receptor interaction and biological activity. J Biol Chem. 1976 Mar 10; 251(5):1239-46.
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Spiegel AM, Brown EM, Fedak SA, Woodard CJ, Aurbach GD. Holocatalytic state of adenylate cyclase in turkey erythrocyte membranes: formation with guanylylimidodiphosphate plus isoproterenol without effect on affinity of beta-receptor. J Cyclic Nucleotide Res. 1976; 2(1):47-56.
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Gardner JD, Aurbach GD, Spiegel AM, Brown EM. Receptor function and ion transport in turkey erythrocytes. Recent Prog Horm Res. 1976; 32:567-95.
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Brown EM, Ulmer DD, Vallee BL. Hydrogen-tritium exchange of partially and fully reconstituted zinc and cobalt alkaline phosphatase of Escherichia coli. Biochemistry. 1974 Dec 17; 13(26):5328-34.
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