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Ralph Scully, PH.D., M.B.,B.S.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Cls 438
330 Brookline Ave
Boston MA 02215
Phone617/735-2041
Fax617/667-0980

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R. BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids. Nat Commun. 2013 Sep 2; 4:2404.
    View in: PubMed
  2. Scully R, Xie A. Double strand break repair functions of histone H2AX. Mutat Res. 2013 Oct; 750(1-2):5-14.
    View in: PubMed
  3. Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov. 2013 Aug; 3(8):870-9.
    View in: PubMed
  4. Somyajit K, Basavaraju S, Scully R, Nagaraju G. ATM- and ATR-Mediated Phosphorylation of XRCC3 Regulates DNA Double-Strand Break-Induced Checkpoint Activation and Repair. Mol Cell Biol. 2013 May; 33(9):1830-44.
    View in: PubMed
  5. Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R. Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks. PLoS One. 2012; 7(11):e49211.
    View in: PubMed
  6. Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, Cantley LC, Wulf GM. Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer. Cancer Discov. 2012 Nov; 2(11):1048-63.
    View in: PubMed
  7. Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Mol Cell Biol. 2012 Oct; 32(19):3963-77.
    View in: PubMed
  8. Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM. BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell. 2011 Oct 21; 44(2):235-51.
    View in: PubMed
  9. Chandramouly G, Willis NA, Scully R. A protective role for BRCA2 at stalled replication forks. Breast Cancer Res. 2011; 13(5):314.
    View in: PubMed
  10. Scully R. Epistatic relationships in the BRCA1-BRCA2 pathway. PLoS Genet. 2011 Jul; 7(7):e1002183.
    View in: PubMed
  11. Dumitrache LC, Hu L, Son MY, Li H, Wesevich A, Scully R, Stark J, Hasty P. Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair. Genetics. 2011 Aug; 188(4):787-97.
    View in: PubMed
  12. Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev. 2011 Apr 1; 25(7):685-700.
    View in: PubMed
  13. Hartlerode A, Odate S, Shim I, Brown J, Scully R. Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein. PLoS One. 2011; 6(3):e16501.
    View in: PubMed
  14. Scully R. The spindle-assembly checkpoint, aneuploidy, and gastrointestinal cancer. N Engl J Med. 2010 Dec 30; 363(27):2665-6.
    View in: PubMed
  15. Xie A, Odate S, Chandramouly G, Scully R. H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle. 2010 Sep 1; 9(17):3602-10.
    View in: PubMed
  16. Scully R. A histone code for DNA repair. Nat Rev Mol Cell Biol. 2010 Mar; 11(3):164.
    View in: PubMed
  17. Hartlerode AJ, Scully R. Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J. 2009 Oct 15; 423(2):157-68.
    View in: PubMed
  18. Xie A, Kwok A, Scully R. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol. 2009 Aug; 16(8):814-8.
    View in: PubMed
  19. Nagaraju G, Hartlerode A, Kwok A, Chandramouly G, Scully R. XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. Mol Cell Biol. 2009 Aug; 29(15):4283-94.
    View in: PubMed
  20. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18.
    View in: PubMed
  21. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell. 2007 Dec 28; 28(6):1045-57.
    View in: PubMed
  22. Xie A, Scully R. Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX. Mol Cell. 2007 Jul 20; 27(2):178-9.
    View in: PubMed
  23. Nagaraju G, Scully R. Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks. DNA Repair (Amst). 2007 Jul 1; 6(7):1018-31.
    View in: PubMed
  24. Nagaraju G, Odate S, Xie A, Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol Cell Biol. 2006 Nov; 26(21):8075-86.
    View in: PubMed
  25. Scully R, Xie A. In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases. Oncogene. 2005 Apr 18; 24(17):2871-6.
    View in: PubMed
  26. Puget N, Knowlton M, Scully R. Molecular analysis of sister chromatid recombination in mammalian cells. DNA Repair (Amst). 2005 Feb 3; 4(2):149-61.
    View in: PubMed
  27. Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R. Control of sister chromatid recombination by histone H2AX. Mol Cell. 2004 Dec 22; 16(6):1017-25.
    View in: PubMed
  28. Scully R, Xie A. BRCA1 and BRCA2 in breast cancer predisposition and recombination control. J Mammary Gland Biol Neoplasia. 2004 Jul; 9(3):237-46.
    View in: PubMed
  29. Scully R, Xie A, Nagaraju G. Molecular functions of BRCA1 in the DNA damage response. Cancer Biol Ther. 2004 Jun; 3(6):521-7.
    View in: PubMed
  30. Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA. Novel consensus DNA-binding sequence for BRCA1 protein complexes. Mol Carcinog. 2003 Oct; 38(2):85-96.
    View in: PubMed
  31. Avni D, Yang H, Martelli F, Hofmann F, ElShamy WM, Ganesan S, Scully R, Livingston DM. Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Mol Cell. 2003 Sep; 12(3):735-46.
    View in: PubMed
  32. Scully R, Puget N. Hereditary breast and ovarian cancer genes. Methods Mol Biol. 2003; 222:41-57.
    View in: PubMed
  33. Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8173-8.
    View in: PubMed
  34. Scully R, Puget N. BRCA1 and BRCA2 in hereditary breast cancer. Biochimie. 2002 Jan; 84(1):95-102.
    View in: PubMed
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