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Shiladitya Sengupta, PH.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Partners Research Bldg, Room 317
65 Landsdowne St
Cambridge MA 02139
Phone617/768-8993
Other Positions
TitleAssistant Professor of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kulkarni AA, Roy B, Rao PS, Wyant GA, Mahmoud A, Ramachandran M, Sengupta P, Goldman A, Kotamraju VR, Basu S, Mashelkar RA, Ruoslahti E, Dinulescu DM, Sengupta S. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013 Dec 1; 73(23):6987-97.
    View in: PubMed
  2. Papa AL, Sidiqui A, Balasubramanian SU, Sarangi S, Luchette M, Sengupta S, Harfouche R. PEGylated liposomal Gemcitabine: insights into a potential breast cancer therapeutic. Cell Oncol (Dordr). 2013 Dec; 36(6):449-57.
    View in: PubMed
  3. Sengupta S, Mitra S, Bhakat KK. Dual Regulatory Roles of Human AP-Endonuclease (APE1/Ref-1) in CDKN1A/p21 Expression. PLoS One. 2013; 8(7):e68467.
    View in: PubMed
  4. Sengupta S, Kulkarni A. Design principles for clinical efficacy of cancer nanomedicine: a look into the basics. ACS Nano. 2013 Apr 23; 7(4):2878-82.
    View in: PubMed
  5. Sarangi S, Pandey A, Papa AL, Sengupta P, Kopparam J, Dadwal U, Basu S, Sengupta S. P2Y12 receptor inhibition augments cytotoxic effects of cisplatin in breast cancer. Med Oncol. 2013 Jun; 30(2):567.
    View in: PubMed
  6. Papa AL, Basu S, Sengupta P, Banerjee D, Sengupta S, Harfouche R. Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells. BMC Cancer. 2012; 12:419.
    View in: PubMed
  7. Sengupta P, Basu S, Soni S, Pandey A, Roy B, Oh MS, Chin KT, Paraskar AS, Sarangi S, Connor Y, Sabbisetti VS, Kopparam J, Kulkarni A, Muto K, Amarasiriwardena C, Jayawardene I, Lupoli N, Dinulescu DM, Bonventre JV, Mashelkar RA, Sengupta S. Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11294-9.
    View in: PubMed
  8. Paraskar A, Soni S, Roy B, Papa AL, Sengupta S. Rationally designed oxaliplatin-nanoparticle for enhanced antitumor efficacy. Nanotechnology. 2012 Feb 24; 23(7):075103.
    View in: PubMed
  9. Piecewicz SM, Pandey A, Roy B, Xiang SH, Zetter BR, Sengupta S. Insulin-like growth factors promote vasculogenesis in embryonic stem cells. PLoS One. 2012; 7(2):e32191.
    View in: PubMed
  10. Roy RS, Roy B, Sengupta S. Emerging technologies for enabling proangiogenic therapy. Nanotechnology. 2011 Dec 9; 22(49):494004.
    View in: PubMed
  11. Paraskar A, Soni S, Basu S, Amarasiriwardena CJ, Lupoli N, Srivats S, Roy RS, Sengupta S. Rationally engineered polymeric cisplatin nanoparticles for improved antitumor efficacy. Nanotechnology. 2011 Jul 1; 22(26):265101.
    View in: PubMed
  12. Sengupta P, Basu S, Sengupta S. Cancer, signal transduction and nanotechnology. Curr Drug Deliv. 2011 May; 8(3):254-60.
    View in: PubMed
  13. Banerjee D, Harfouche R, Sengupta S. Nanotechnology-mediated targeting of tumor angiogenesis. Vasc Cell. 2011; 3(1):3.
    View in: PubMed
  14. Piecewicz S, Sengupta S. The dynamic glycome microenvironment and stem cell differentiation into vasculature. Stem Cells Dev. 2011 May; 20(5):749-58.
    View in: PubMed
  15. Banerjee D, Sengupta S. Nanoparticles in cancer chemotherapy. Prog Mol Biol Transl Sci. 2011; 104:489-507.
    View in: PubMed
  16. Sinha Roy R, Soni S, Harfouche R, Vasudevan PR, Holmes O, de Jonge H, Rowe A, Paraskar A, Hentschel DM, Chirgadze D, Blundell TL, Gherardi E, Mashelkar RA, Sengupta S. Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis. Proc Natl Acad Sci U S A. 2010 Aug 3; 107(31):13608-13.
    View in: PubMed
  17. Paraskar AS, Soni S, Chin KT, Chaudhuri P, Muto KW, Berkowitz J, Handlogten MW, Alves NJ, Bilgicer B, Dinulescu DM, Mashelkar RA, Sengupta S. Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12435-40.
    View in: PubMed
  18. Agarwal S, Dugar D, Sengupta S. Ranking chemical structures for drug discovery: a new machine learning approach. J Chem Inf Model. 2010 May 24; 50(5):716-31.
    View in: PubMed
  19. Chaudhuri P, Harfouche R, Soni S, Hentschel DM, Sengupta S. Shape effect of carbon nanovectors on angiogenesis. ACS Nano. 2010 Jan 26; 4(1):574-82.
    View in: PubMed
  20. Chaudhuri P, Soni S, Sengupta S. Single-walled carbon nanotube-conjugated chemotherapy exhibits increased therapeutic index in melanoma. Nanotechnology. 2010 Jan 15; 21(2):025102.
    View in: PubMed
  21. Basu S, Chaudhuri P, Sengupta S. Targeting oncogenic signaling pathways by exploiting nanotechnology. Cell Cycle. 2009 Nov 1; 8(21):3480-7.
    View in: PubMed
  22. Harfouche R, Hentschel DM, Piecewicz S, Basu S, Print C, Eavarone D, Kiziltepe T, Sasisekharan R, Sengupta S. Glycome and transcriptome regulation of vasculogenesis. Circulation. 2009 Nov 10; 120(19):1883-92.
    View in: PubMed
  23. Chaudhuri P, Paraskar A, Soni S, Mashelkar RA, Sengupta S. Fullerenol-cytotoxic conjugates for cancer chemotherapy. ACS Nano. 2009 Sep 22; 3(9):2505-14.
    View in: PubMed
  24. Basu S, Harfouche R, Soni S, Chimote G, Mashelkar RA, Sengupta S. Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7957-61.
    View in: PubMed
  25. Harfouche R, Basu S, Soni S, Hentschel DM, Mashelkar RA, Sengupta S. Nanoparticle-mediated targeting of phosphatidylinositol-3-kinase signaling inhibits angiogenesis. Angiogenesis. 2009; 12(4):325-38.
    View in: PubMed
  26. Sengupta S, Sasisekharan R. Exploiting nanotechnology to target cancer. Br J Cancer. 2007 May 7; 96(9):1315-9.
    View in: PubMed
  27. Sengupta S, Chakrabarti S, Roy A, Panda CK, Roychoudhury S. Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype. Cancer. 2007 Feb 15; 109(4):703-12.
    View in: PubMed
  28. Mondal G, Sengupta S, Panda CK, Gollin SM, Saunders WS, Roychoudhury S. Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer. Carcinogenesis. 2007 Jan; 28(1):81-92.
    View in: PubMed
  29. Chakrabarti S, Sengupta S, Sengupta A, Basak SN, Roy A, Panda C, Roychoudhury S. Genomic instabilities in squamous cell carcinoma of head and neck from the Indian population. Mol Carcinog. 2006 Apr; 45(4):270-7.
    View in: PubMed
  30. Sengupta S, Eavarone D, Capila I, Zhao G, Watson N, Kiziltepe T, Sasisekharan R. Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature. 2005 Jul 28; 436(7050):568-72.
    View in: PubMed
  31. Sengupta S, Sellers LA, Gherardi E, Sasisekharan R, Fan TP. Nitric oxide modulates hepatocyte growth factor/scatter factor-induced angiogenesis. Angiogenesis. 2004; 7(4):285-94.
    View in: PubMed
  32. Sengupta S, Toh SA, Sellers LA, Skepper JN, Koolwijk P, Leung HW, Yeung HW, Wong RN, Sasisekharan R, Fan TP. Modulating angiogenesis: the yin and the yang in ginseng. Circulation. 2004 Sep 7; 110(10):1219-25.
    View in: PubMed
  33. Sengupta S, Kiziltepe T, Sasisekharan R. A dual-color fluorescence imaging-based system for the dissection of antiangiogenic and chemotherapeutic activity of molecules. FASEB J. 2004 Oct; 18(13):1565-7.
    View in: PubMed
  34. Qi Y, Zhao G, Liu D, Shriver Z, Sundaram M, Sengupta S, Venkataraman G, Langer R, Sasisekharan R. Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9867-72.
    View in: PubMed
  35. Sengupta S, Sellers LA, Cindrova T, Skepper J, Gherardi E, Sasisekharan R, Fan TP. Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis. Cancer Res. 2003 Dec 1; 63(23):8351-9.
    View in: PubMed
  36. Johnson NA, Sengupta S, Saidi SA, Lessan K, Charnock-Jones SD, Scott L, Stephens R, Freeman TC, Tom BD, Harris M, Denyer G, Sundaram M, Sasisekharan R, Smith SK, Print CG. Endothelial cells preparing to die by apoptosis initiate a program of transcriptome and glycome regulation. FASEB J. 2004 Jan; 18(1):188-90.
    View in: PubMed
  37. Sengupta S, Sellers LA, Li RC, Gherardi E, Zhao G, Watson N, Sasisekharan R, Fan TP. Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis. Circulation. 2003 Jun 17; 107(23):2955-61.
    View in: PubMed
  38. Sengupta S, Sellers LA, Matheson HB, Fan TP. Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms. Br J Pharmacol. 2003 May; 139(2):219-31.
    View in: PubMed
  39. Sengupta S, Gherardi E, Sellers LA, Wood JM, Sasisekharan R, Fan TP. Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2003 Jan 1; 23(1):69-75.
    View in: PubMed
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