Barbara Wegiel, Ph.D.
|Title||Assistant Professor of Surgery|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Beth Israel Deaconess Medical Center|
CLS601 - 3 Blackfan Circle
330 Brookline Ave
Boston MA 02215
Available: 10/04/13, Expires: 01/30/15
A major interest of our laboratory is heme degradation pathway and cytoprotective protein, heme oxygenase-1, which during heme catalysis generates carbon monoxide (CO), iron and biliverdin (BV). HO-1 acts in concert with biliverdin reductase (BVR) to form one of the strongest antioxidant, bilirubin (BR). We focus on the role of HO-1 and BVR in inflammation and tumor biology. We have demonstrated that HO-1 is critical regulator of DNA repair pathways and hypothesized its contribution in cancer, premature aging and other diseases. Further, we have uncovered novel properties of BVR to act as a signaling molecule and mediate anti-inflammatory effects of BV. We continue to explore a role of BVR using our newly generated BVR-fl/fl conditional knockout mice as well as transgenic models of carcinogenesis. Our hypothesis is that BVR is a major signaling molecule that is activated upon conversion of BV to BR and has potent regulatory effects in the innate immune system.
Student role: work with transgenic and conditional knockout mice colony, coculture of TAM with cancer cells, in vitro cell culture and treatment, learning and applying multiple biochemical and molecular biology assays.
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