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Joshua M. Kaplan, PH.D.

TitleProfessor of Neurobiology
InstitutionMassachusetts General Hospital
DepartmentNeurobiology
AddressMassachusetts General Hospital
Simches Research Ctr CPZN# 7810
185 Cambridge St
Boston MA 02114
Phone617/726-5962
Fax617/726-6893

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hu Z, Tong XJ, Kaplan JM. UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans. Elife. 2013; 2:e00967.
    View in: PubMed
  2. Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, and Kaplan JM (2013). . Analysis of NPR-1 Reveals a Circuit Mechanism for Behavioral Quiescence in C. elegans. . Neuron. 2013; 5(78):869-80.
  3. Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, Kaplan JM. Analysis of NPR-1 Reveals a Circuit Mechanism for Behavioral Quiescence in C. elegans. Neuron. 2013 Jun 5; 78(5):869-80.
    View in: PubMed
  4. Hu Z, Hom S, Kudze T, Tong XJ, Choi S, Aramuni G, Zhang W, Kaplan JM. Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science. 2012 Aug 24; 337(6097):980-4.
    View in: PubMed
  5. Thompson-Peer KL, Bai J, Hu Z, Kaplan JM. HBL-1 patterns synaptic remodeling in C. elegans. Neuron. 2012 Feb 9; 73(3):453-65.
    View in: PubMed
  6. Hao Y, Hu Z, Sieburth D, Kaplan JM. RIC-7 promotes neuropeptide secretion. PLoS Genet. 2012 Jan; 8(1):e1002464.
    View in: PubMed
  7. Babu K, Hu Z, Chien SC, Garriga G, Kaplan JM. The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling. Neuron. 2011 Jul 14; 71(1):103-16.
    View in: PubMed
  8. Hu Z, Pym EC, Babu K, Vashlishan Murray AB, Kaplan JM. A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release. Neuron. 2011 Jul 14; 71(1):92-102.
    View in: PubMed
  9. Bai J, Hu Z, Dittman JS, Pym EC, Kaplan JM. Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis. Cell. 2010 Oct 29; 143(3):430-41.
    View in: PubMed
  10. Ch'ng Q, Sieburth D, Kaplan JM. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008 Nov; 4(11):e1000283.
    View in: PubMed
  11. Dittman JS, Kaplan JM. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. J Neurosci. 2008 Jul 9; 28(28):7104-12.
    View in: PubMed
  12. McEwen JM, Kaplan JM. UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin. Mol Biol Cell. 2008 Sep; 19(9):3836-46.
    View in: PubMed
  13. Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008 May 30; 133(5):903-15.
    View in: PubMed
  14. Vashlishan AB, Madison JM, Dybbs M, Bai J, Sieburth D, Ch'ng Q, Tavazoie M, Kaplan JM. An RNAi screen identifies genes that regulate GABA synapses. Neuron. 2008 May 8; 58(3):346-61.
    View in: PubMed
  15. Chun DK, McEwen JM, Burbea M, Kaplan JM. UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans. Mol Biol Cell. 2008 Jul; 19(7):2682-95.
    View in: PubMed
  16. Juo P, Harbaugh T, Garriga G, Kaplan JM. CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans. Mol Biol Cell. 2007 Oct; 18(10):3883-93.
    View in: PubMed
  17. Sieburth D, Madison JM, Kaplan JM. PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007 Jan; 10(1):49-57.
    View in: PubMed
  18. McEwen JM, Madison JM, Dybbs M, Kaplan JM. Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13. Neuron. 2006 Aug 3; 51(3):303-15.
    View in: PubMed
  19. Dittman JS, Kaplan JM. Factors regulating the abundance and localization of synaptobrevin in the plasma membrane. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11399-404.
    View in: PubMed
  20. Madison JM, Nurrish S, Kaplan JM. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr Biol. 2005 Dec 20; 15(24):2236-42.
    View in: PubMed
  21. Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature. 2005 Jul 28; 436(7050):510-7.
    View in: PubMed
  22. Dybbs M, Ngai J, Kaplan JM. Using microarrays to facilitate positional cloning: identification of tomosyn as an inhibitor of neurosecretion. PLoS Genet. 2005 Jul; 1(1):6-16.
    View in: PubMed
  23. Dreier L, Burbea M, Kaplan JM. LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Neuron. 2005 Apr 7; 46(1):51-64.
    View in: PubMed
  24. Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science. 2005 May 20; 308(5725):1164-7.
    View in: PubMed
  25. Juo P, Kaplan JM. The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Curr Biol. 2004 Nov 23; 14(22):2057-62.
    View in: PubMed
  26. Grunwald ME, Mellem JE, Strutz N, Maricq AV, Kaplan JM. Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade. Proc Natl Acad Sci U S A. 2004 Mar 2; 101(9):3190-5.
    View in: PubMed
  27. Grunwald ME, Kaplan JM. Mutations in the ligand-binding and pore domains control exit of glutamate receptors from the endoplasmic reticulum in C. elegans. Neuropharmacology. 2003 Nov; 45(6):768-76.
    View in: PubMed
  28. Jacob TC, Kaplan JM. The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. J Neurosci. 2003 Mar 15; 23(6):2122-30.
    View in: PubMed
  29. Burbea M, Dreier L, Dittman JS, Grunwald ME, Kaplan JM. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron. 2002 Jul 3; 35(1):107-20.
    View in: PubMed
  30. Kass J, Jacob TC, Kim P, Kaplan JM. The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J Neurosci. 2001 Dec 1; 21(23):9265-72.
    View in: PubMed
  31. Rongo C, Kaplan JM. CaMKII regulates the density of central glutamatergic synapses in vivo. Nature. 1999 Nov 11; 402(6758):195-9.
    View in: PubMed
  32. Lackner MR, Nurrish SJ, Kaplan JM. Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release. Neuron. 1999 Oct; 24(2):335-46.
    View in: PubMed
  33. Nurrish S, Ségalat L, Kaplan JM. Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites. Neuron. 1999 Sep; 24(1):231-42.
    View in: PubMed
  34. Hart AC, Kass J, Shapiro JE, Kaplan JM. Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron. J Neurosci. 1999 Mar 15; 19(6):1952-8.
    View in: PubMed
  35. Rongo C, Whitfield CW, Rodal A, Kim SK, Kaplan JM. LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell. 1998 Sep 18; 94(6):751-9.
    View in: PubMed
  36. Berger AJ, Hart AC, Kaplan JM. G alphas-induced neurodegeneration in Caenorhabditis elegans. J Neurosci. 1998 Apr 15; 18(8):2871-80.
    View in: PubMed
  37. Elkes DA, Cardozo DL, Madison J, Kaplan JM. EGL-36 Shaw channels regulate C. elegans egg-laying muscle activity. Neuron. 1997 Jul; 19(1):165-74.
    View in: PubMed
  38. Kaplan JM. Sensory signaling in Caenorhabditis elegans. Curr Opin Neurobiol. 1996 Aug; 6(4):494-9.
    View in: PubMed
  39. Hart AC, Sims S, Kaplan JM. Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. Nature. 1995 Nov 2; 378(6552):82-5.
    View in: PubMed
  40. Ségalat L, Elkes DA, Kaplan JM. Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans. Science. 1995 Mar 17; 267(5204):1648-51.
    View in: PubMed
  41. Kaplan JM, Horvitz HR. A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2227-31.
    View in: PubMed
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