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Lucia Sobrin, M.D.

TitleAssistant Professor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infrm
Ophthalmology
243 Charles St
Boston MA 02114
Phone6175734279

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP, Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B, Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA, Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y, Katsanis N, N Keilhauer C, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P, Lotery AJ, Meitinger T, Mitchell P, Mohand-Saïd S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y, Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R, Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H, Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM, Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR, Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM, Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR, Swaroop A, Weber BH, Kubo M, Deangelis MM, Léveillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, Abecasis GR. Seven new loci associated with age-related macular degeneration. Nat Genet. 2013 Apr; 45(4):433-9.
    View in: PubMed
  2. Faez S, Loewenstein J, Sobrin L. Concordance of antiretinal antibody testing results between laboratories in autoimmune retinopathy. JAMA Ophthalmol. 2013 Jan 1; 131(1):113-5.
    View in: PubMed
  3. Sobrin L. Longitudinal validation of hemoglobin a1c criteria for diabetes diagnosis: risk of retinopathy. Diabetes. 2012 Dec; 61(12):3074-5.
    View in: PubMed
  4. Wing-See Lau T, Wong IY, Sobrin L. Diagnostic and therapeutic challenges. Retina. 2012 Sep; 32(8):1674-7.
    View in: PubMed
  5. Hunter RS, Skondra D, Papaliodis G, Sobrin L. Role of OCT in the Diagnosis and Management of Macular Edema from Uveitis. Semin Ophthalmol. 2012 Sep; 27(5-6):241-6.
    View in: PubMed
  6. Fawzi AA, Pappuru RR, Sarraf D, Le PP, McCannel CA, Sobrin L, Goldstein DA, Honowitz S, Walsh AC, Sadda SR, Jampol LM, Eliott D. Acute macular neuroretinopathy: long-term insights revealed by multimodal imaging. Retina. 2012 Sep; 32(8):1500-13.
    View in: PubMed
  7. Suzuki J, Yoshimura T, Simeonova M, Takeuchi K, Murakami Y, Morizane Y, Miller JW, Sobrin L, Vavvas DG. Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2012; 53(7):4158-69.
    View in: PubMed
  8. Sobrin L, Ripke S, Yu Y, Fagerness J, Bhangale TR, Tan PL, Souied EH, Buitendijk GH, Merriam JE, Richardson AJ, Raychaudhuri S, Reynolds R, Chin KA, Lee AY, Leveziel N, Zack DJ, Campochiaro P, Smith RT, Barile GR, Hogg RE, Chakravarthy U, Behrens TW, Uitterlinden AG, van Duijn CM, Vingerling JR, Brantley MA, Baird PN, Klaver CC, Allikmets R, Katsanis N, Graham RR, Ioannidis JP, Daly MJ, Seddon JM. Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology. 2012 Sep; 119(9):1874-85.
    View in: PubMed
  9. Huynh N, Shildkrot Y, Lobo AM, Sobrin L. Intravitreal triamcinolone for cancer-associated retinopathy refractory to systemic therapy. J Ophthalmic Inflamm Infect. 2012 Sep; 2(3):169-71.
    View in: PubMed
  10. Pachydaki SI, Jakobiec FA, Bhat P, Sobrin L, Michaud NA, Seshan SV, D'Amico DJ. Surgical management and ultrastructural study of choroidal neovascularization in punctate inner choroidopathy after bevacizumab. J Ophthalmic Inflamm Infect. 2012 Mar; 2(1):29-37.
    View in: PubMed
  11. Sobrin L, Green T, Sim X, Jensen RA, Tai ES, Tay WT, Wang JJ, Mitchell P, Sandholm N, Liu Y, Hietala K, Iyengar SK, Brooks M, Buraczynska M, Van Zuydam N, Smith AV, Gudnason V, Doney AS, Morris AD, Leese GP, Palmer CN, Swaroop A, Taylor HA, Wilson JG, Penman A, Chen CJ, Groop PH, Saw SM, Aung T, Klein BE, Rotter JI, Siscovick DS, Cotch MF, Klein R, Daly MJ, Wong TY. Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). Invest Ophthalmol Vis Sci. 2011 Sep; 52(10):7593-602.
    View in: PubMed
  12. Suzuki J, Manola A, Murakami Y, Morizane Y, Takeuchi K, Kayama M, Miller JW, Sobrin L, Vavvas DG. Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2011 Aug; 52(9):6565-71.
    View in: PubMed
  13. Comander J, Loewenstein J, Sobrin L. Diagnostic testing and disease monitoring in birdshot chorioretinopathy. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):329-36.
    View in: PubMed
  14. Shildkrot Y, Sobrin L, Gragoudas ES. Cancer-associated retinopathy: update on pathogenesis and therapy. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):321-8.
    View in: PubMed
  15. Benitah NR, Sobrin L, Papaliodis GN. The use of biologic agents in the treatment of ocular manifestations of Behcet's disease. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):295-303.
    View in: PubMed
  16. Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet. 2011 Sep 15; 20(18):3699-709.
    View in: PubMed
  17. Lobo AM, Stacy R, Cestari D, Stone JH, Jakobiec FA, Sobrin L. Optic nerve involvement with panuveitis in Sweet syndrome. Ocul Immunol Inflamm. 2011 Jun; 19(3):167-70.
    View in: PubMed
  18. Gupta M, Durand ML, Sobrin L. Vancomycin resistance in ocular infections. Int Ophthalmol Clin. 2011; 51(4):167-81.
    View in: PubMed
  19. Kanoff J, Sobrin L. New diagnosis and treatment paradigms in acute retinal necrosis. Int Ophthalmol Clin. 2011; 51(4):25-31.
    View in: PubMed
  20. Sobrin L, Reynolds R, Yu Y, Fagerness J, Leveziel N, Bernstein PS, Souied EH, Daly MJ, Seddon JM. ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration. Am J Ophthalmol. 2011 Feb; 151(2):345-52.e3.
    View in: PubMed
  21. Lobo AM, Sobrin L, Papaliodis GN. Drug delivery options for the treatment of ocular inflammation. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):283-8.
    View in: PubMed
  22. Raychaudhuri S, Ripke S, Li M, Neale BM, Fagerness J, Reynolds R, Sobrin L, Swaroop A, Abecasis G, Seddon JM, Daly MJ. Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent. Nat Genet. 2010 Jul; 42(7):553-5; author reply 555-6.
    View in: PubMed
  23. Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, Tan PL, Oh EC, Merriam JE, Souied E, Bernstein PS, Li B, Frederick JM, Zhang K, Brantley MA, Lee AY, Zack DJ, Campochiaro B, Campochiaro P, Ripke S, Smith RT, Barile GR, Katsanis N, Allikmets R, Daly MJ, Seddon JM. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7395-400.
    View in: PubMed
  24. Sobrin L, Maller JB, Neale BM, Reynolds RC, Fagerness JA, Daly MJ, Seddon JM. Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach. Eur J Hum Genet. 2010 Apr; 18(4):496-501.
    View in: PubMed
  25. Bhat PV, Jakobiec FA, Papaliodis G, Sobrin L. Primary T-cell lymphoma of the retina and cerebellum: immunophenotypic and gene rearrangement confirmation. Am J Ophthalmol. 2009 Sep; 148(3):350-60.
    View in: PubMed
  26. Sobrin L, Huang JJ, Christen W, Kafkala C, Choopong P, Foster CS. Daclizumab for treatment of birdshot chorioretinopathy. Arch Ophthalmol. 2008 Feb; 126(2):186-91.
    View in: PubMed
  27. Sobrin L, Christen W, Foster CS. Mycophenolate mofetil after methotrexate failure or intolerance in the treatment of scleritis and uveitis. Ophthalmology. 2008 Aug; 115(8):1416-21, 1421.e1.
    View in: PubMed
  28. Montezuma SR, Rizzo J, Shah A, Snebold N, Sobrin L. HLA-B27-associated papillitis and vasculitis masquerading as idiopathic intracranial hypertension (IIH). North American Neuro-Ophthalmology Society Meeting, Orlando, Florida. 2008.
  29. Sobrin L, Kim IK. Intravitreal bevacizumab as primary treatment for subfoveal choroidal neovascularization secondary to posterior uveitis. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2008.
  30. Montezuma SR, Papaliodis G, Sobrin L. Intravitreal bevacizumab appears to be effective in the treatment of refractory uveitic cystoid macular edema. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2008.
  31. Montezuma SR, Sobrin L, Seddon JM. Review of genetics in age related macular degeneration. Semin Ophthalmol. 2007 Oct-Dec; 22(4):229-40.
    View in: PubMed
  32. Sobrin L, Kump LI, Foster CS. Intravitreal clindamycin for toxoplasmic retinochoroiditis. Retina. 2007 Sep; 27(7):952-7.
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  33. Sobrin L, Kim EC, Christen W, Papadaki T, Letko E, Foster CS. Infliximab therapy for the treatment of refractory ocular inflammatory disease. Arch Ophthalmol. 2007 Jul; 125(7):895-900.
    View in: PubMed
  34. Gerstenblith AT, Thorne JE, Sobrin L, Do DV, Shah SM, Foster CS, Jabs DA, Nguyen QD. Punctate inner choroidopathy: a survey analysis of 77 persons. Ophthalmology. 2007 Jun; 114(6):1201-4.
    View in: PubMed
  35. Cordero Coma M, Sobrin L, Onal S, Christen W, Foster CS. Intravitreal bevacizumab for treatment of uveitic macular edema. Ophthalmology. 2007 Aug; 114(8):1574-1579.e1.
    View in: PubMed
  36. Cordero-Coma M, Anzaar F, Sobrin L, Foster CS. Systemic immunomodulatory therapy in severe dry eye secondary to inflammation. Ocul Immunol Inflamm. 2007 Mar-Apr; 15(2):99-104.
    View in: PubMed
  37. Pachydaki S, Sobrin L, Miller JW. Photodynamic therapy and combination treatments. Int Ophthalmol Clin. 2007; 47(1):95-115.
    View in: PubMed
  38. Murray TG, Markoe AM, Schiffman JC, Sobrin L. Long-term survival outcomes for patients undergoing observational management prior to definitive iodine-125 brachytherapy: ten-year follow-up of a prospective cohort. Retina Society Annual Meeting, Boston, Massachusetts. 2007.
  39. Sobrin L, Foster CS. Cytomegalovirus retinitis after one decade of HAART. Int Ophthalmol Clin. 2007; 47(2):155-64.
    View in: PubMed
  40. Seddon JM, Sobrin L. Epidemiology of age-related macular degeneration. Albert D, Miller J, Azar D, Blodi B, editors. Albert & Jakobiec’s Principles and Practice of Ophthalmology. 2007; 413-22.
  41. Leroy S, Sobrin L, Hannon W, Temple C. The association between melanoma recurrence and RT-PCR sentinel node status: a systematic review and meta-analysis. Canadian Society of Plastic Surgeons Meeting, Banff, Alberta. 2007.
  42. Sobrin L. Evolving therapies for macular edema. Ophthalmology Rounds. 2007; 1(8):1-6.
  43. Foster CS, Sobrin L. Systemic lupus erythematosus. In: Albert D, Miller J, Azar D, Blodi B, editors. Albert & Jakobiec’s Principles and Practice of Ophthalmology. 2007; 4429-36.
  44. Sobrin L, Davis JL. Management of ocular symptoms and signs. Yu VL, Burdette SD, editors. Antimicrobial therapies and vaccines: Empiric. 2007.
  45. Rhee DJ, Colby KA, Rapuano CJ, Sobrin L, editors. Ophthalmic Drug Guide. 2006.
  46. Sobrin L, Miller JW. Optical coherence tomography pseudo-macular hole appearance after photodynamic therapy. Br J Ophthalmol. 2006 Nov; 90(11):1434-5.
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  47. Murray TG, Sobrin L. The case for observational management of suspected small choroidal melanoma. Arch Ophthalmol. 2006 Sep; 124(9):1342-4.
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  48. Nakazawa T, Matsubara A, Noda K, Hisatomi T, She H, Skondra D, Miyahara S, Sobrin L, Thomas KL, Chen DF, Grosskreutz CL, Hafezi-Moghadam A, Miller JW. Characterization of cytokine responses to retinal detachment in rats. Mol Vis. 2006; 12:867-78.
    View in: PubMed
  49. Onal S, Sobrin L, Foster CS. Long-term immunosuppressive therapy for sympathetic ophthalmia. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2006.
  50. Anzaar F, Bhat P, Quinones K, Sobrin L, Foster CS. The use of mycophenolate mofetil in reclacitrant juvenile idiopathic arthritis-associated uveitis. American Uveitis Society Meeting, Las Vegas, Nevada. 2006.
  51. Pachydaki SI, Sobrin L, Nakazawa T, Zacks DN, Miller J, Grosskreutz CL. Effect of systemic administration of FK506 in a rat model of retinal detachment. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2006.
  52. Sobrin L, Kim EC, Papadaki T, Letko E, Foster CS. Infliximab for the treatment of refractory ocular inflammatory disease. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2006.
  53. Gerstenblith AT, Thorne J, Jabs DA, Foster CS, Sobrin L, Do DV, Nguyen QD. Analysis of survey of patients with punctate inner choroidopathy. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2006.
  54. Sobrin L, Foster CS. Systemic lupus erythematosus. Contemporary Ophthalmology. 2006; 5:1-8.
  55. Sobrin L, Huang JJ, Choopong P, Foster CS. Daclizumab for patients with birdshot retinochoroidopathy refractory to traditional immunomodulatory therapy. American Academy of Ophthalmology Annual Meeting, Las Vegas, Nevada. 2006.
  56. Cordero M, Anzaar F, Sobrin L, Foster CS. Systemic immunomodulatory therapy in severe dry eye secondary to dacryoadenitis. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2006.
  57. Cordero Coma M, Sobrin L, Foster CS. Sympathetic ophthalmia. Contemporary Ophthalmology. 2006; 5:1-8.
  58. Sobrin L, Schiffman JC, Markoe AM, Murray TG. Outcomes of iodine 125 plaque radiotherapy after initial observation of suspected small choroidal melanomas: a pilot study. Ophthalmology. 2005 Oct; 112(10):1777-83.
    View in: PubMed
  59. Sobrin L, Lam BL, Liu M, Feuer WJ, Davis JL. Electroretinographic monitoring in birdshot chorioretinopathy. Am J Ophthalmol. 2005 Jul; 140(1):52-64.
    View in: PubMed
  60. Sobrin L, Dubovy SR, Davis JL, Murray TG. Isolated, bilateral intraocular lymphoma in a 15-year-old girl. Retina. 2005 Apr-May; 25(3):370-3.
    View in: PubMed
  61. Sobrin L, Kim EC, Papadaki T, Letko E, Foster CS. Infliximab for the treatment of refractory ocular inflammatory disease. American Uveitis Society Meeting, Chicago, Illinois. 2005.
  62. Sobrin L, D'Amico DJ. Controversies in intravitreal triamcinolone acetonide use. Int Ophthalmol Clin. 2005; 45(4):133-41.
    View in: PubMed
  63. Sobrin L, Pachydaki SI, Nakazawa T, Grosskreutz Cl, Zacks DN, Miller JW. Effect of systemic neuroprotective agents on photoreceptor apoptosis in a rat model of retinal detachment. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2005.
  64. Nakazawa T, Matsubara A, Chen DF, Sobrin L, Noda K, Skondra D, Grosskreutz CL, Hafezi-Moghadam A, Miller JW. Characterization of cytokine responses to retinal detachment in rats. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2005.
  65. Pachydaki SI, Sobrin L, Nakazawa T, Grosskreutz CL, Zacks DN, Miller JW. Characterization of effects of systemic antibiotics in a rat model of retinal detachment. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2005.
  66. Sobrin L, Hayden BC, Murray TG, Cicciarelli N, Scott IU, Hernandez E, Wu X, Markoe AM, Feuer W, Fulton L, O'Brien JM. External beam radiation "salvage" therapy in transgenic murine retinoblastoma. Arch Ophthalmol. 2004 Feb; 122(2):251-7.
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  67. Sobrin L, Young TA, Sharma A, Nakazawa T, Grosskreutz Cl, Zacks DN, Miller JW. Pigment epithelial-derived factor (PEDF) inhibits apoptosis in a rat model of retinal detachment. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2004.
  68. Young TA, Nakazawa T, Sobrin L, Sharma A, Grosskreutz CL, Gragoudas ES, Miller JW. Modulation of apoptosis following combination PEDF and photodynamic therapy for choroidal neovascularization in the rat model. Association for Research in Vision and Ophthalmology Annual Meeting, Ft. Lauderdale, Florida. 2004.
  69. Sobrin L, Berrocal AM, Murray TG. Retinal detachment 7 years after prophylactic schisis cavity excision in juvenile X-linked retinoschisis. Ophthalmic Surg Lasers Imaging. 2003 Sep-Oct; 34(5):401-2.
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  70. Sobrin L, Davis JL. Ocular complications. Swindels S, Shafer RW, Singh N, editors. HIV Clinical Manual. 2003; 227-244.
  71. Sobrin L, Liu Z, Monroy DC, Solomon A, Selzer MG, Lokeshwar BL, Pflugfelder SC. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1703-9.
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  72. Afonso AA, Sobrin L, Monroy DC, Selzer M, Lokeshwar B, Pflugfelder SC. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci. 1999 Oct; 40(11):2506-12.
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  73. Fournier AM, Harea C, Ardalan K, Sobrin L . Health fairs as a unique teaching methodology. Teaching and Learning in Medicine. 1999; 11:48-51.
  74. Bourguignon LYW, Mathew L, Sobrin L, Bourguignon GJ. Ca2+ signaling and cytoskeleton reorganization in endothelial cells stimulated by bradykinin. Kohen E, Hirschberg JG, editors. Analytical use of fluorescent probes in oncology. 1996; 309-15.
  75. Bourguignon LY, Iida N, Sobrin L, Bourguignon GJ. Identification of an IP3 receptor in endothelial cells. J Cell Physiol. 1994 Apr; 159(1):29-34.
    View in: PubMed
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