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William Francis Bernhard, M.D.

TitleProfessor of Surgery, Emeritus
InstitutionChildren's Hospital Boston
DepartmentEmeritus
AddressW Roxbury/Brockton VA Med Ctr
1400 VFW Pkwy,(112)Lvad Lab 22
West Roxbury MA 02132
Phone617/323-7700

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Black PJ, Bernhard WA. Excess Electron Trapping in Duplex DNA: Long Range Transfer via Stacked Adenines. J Phys Chem B. 2012 Nov 8; 116(44):13211-8.
    View in: PubMed
  2. Peoples AR, Lee J, Weinfeld M, Milligan JR, Bernhard WA. Yields of damage to C4' deoxyribose and to pyrimidines in pUC18 by the direct effect of ionizing radiation. Nucleic Acids Res. 2012 Jul; 40(13):6060-9.
    View in: PubMed
  3. Black PJ, Bernhard WA. EPR detection of an electron scavenging contaminant in irradiated deoxyoligonucleotides: one-electron reduced benzoyl. J Phys Chem B. 2011 Jun 23; 115(24):8009-13.
    View in: PubMed
  4. Sharma KK, Swarts SG, Bernhard WA. Mechanisms of direct radiation damage to DNA: the effect of base sequence on base end products. J Phys Chem B. 2011 Apr 28; 115(16):4843-55.
    View in: PubMed
  5. Price CS, Razskazovskiy Y, Bernhard WA. Factors affecting the yields of C1' and C5' oxidation products in radiation-damaged DNA: the indirect effect. Radiat Res. 2010 Nov; 174(5):645-9.
    View in: PubMed
  6. Peoples AR, Mercer KR, Bernhard WA. What fraction of DNA double-strand breaks produced by the direct effect is accounted for by radical pairs? J Phys Chem B. 2010 Jul 22; 114(28):9283-8.
    View in: PubMed
  7. Sharma KK, Tyagi R, Purkayastha S, Bernhard WA. One-electron oxidation of DNA by ionizing radiation: competition between base-to-base hole-transfer and hole-trapping. J Phys Chem B. 2010 Jun 10; 114(22):7672-80.
    View in: PubMed
  8. Sharma KK, Bernhard WA. Direct damage to the backbone of DNA oligomers is influenced by the OH moiety at strand ends, by the type of base, and by context. J Phys Chem B. 2009 Sep 24; 113(38):12839-43.
    View in: PubMed
  9. Sharma KK, Razskazovskiy Y, Purkayastha S, Bernhard WA. Mechanisms of strand break formation in DNA due to the direct effect of ionizing radiation: the dependency of free base release on the length of alternating CG oligodeoxynucleotides. J Phys Chem B. 2009 Jun 11; 113(23):8183-91.
    View in: PubMed
  10. Sharma KK, Milligan JR, Bernhard WA. Multiplicity of DNA single-strand breaks produced in pUC18 exposed to the direct effects of ionizing radiation. Radiat Res. 2008 Aug; 170(2):156-62.
    View in: PubMed
  11. Bernhard WA, Purkayastha S, Milligan JR. Which DNA damage is likely to be relevant in hormetic responses? Dose Response. 2008; 6(2):184-95.
    View in: PubMed
  12. Purkayastha S, Milligan JR, Bernhard WA. On the chemical yield of base lesions, strand breaks, and clustered damage generated in plasmid DNA by the direct effect of X rays. Radiat Res. 2007 Sep; 168(3):357-66.
    View in: PubMed
  13. Swarts SG, Gilbert DC, Sharma KK, Razskazovskiy Y, Purkayastha S, Naumenko KA, Bernhard WA. Mechanisms of direct radiation damage in DNA, based on a study of the yields of base damage, deoxyribose damage, and trapped radicals in d(GCACGCGTGC)(2). Radiat Res. 2007 Sep; 168(3):367-81.
    View in: PubMed
  14. Sharma KK, Purkayastha S, Bernhard WA. Unaltered free base release from d(CGCGCG)2 produced by the direct effect of ionizing radiation at 4 K and room temperature. Radiat Res. 2007 May; 167(5):501-7.
    View in: PubMed
  15. Purkayastha S, Milligan JR, Bernhard WA. An investigation into the mechanisms of DNA strand breakage by direct ionization of variably hydrated plasmid DNA. J Phys Chem B. 2006 Dec 28; 110(51):26286-91.
    View in: PubMed
  16. Roginskaya M, Bernhard WA, Razskazovskiy Y. Protection of DNA against direct radiation damage by complex formation with positively charged polypeptides. Radiat Res. 2006 Jul; 166(1 Pt 1):9-18.
    View in: PubMed
  17. Purkayastha S, Milligan JR, Bernhard WA. The role of hydration in the distribution of free radical trapping in directly ionized DNA. Radiat Res. 2006 Jul; 166(1 Pt 1):1-8.
    View in: PubMed
  18. Roginskaya M, Razskazovskiy Y, Bernhard WA. 2-Deoxyribonolactone lesions in X-ray-irradiated DNA: quantitative determination by catalytic 5-methylene-2-furanone release. Angew Chem Int Ed Engl. 2005 Sep 26; 44(38):6210-3.
    View in: PubMed
  19. Purkayastha S, Milligan JR, Bernhard WA. Correlation of free radical yields with strand break yields produced in plasmid DNA by the direct effect of ionizing radiation. J Phys Chem B. 2005 Sep 8; 109(35):16967-73.
    View in: PubMed
  20. Roginskaya M, Bernhard WA, Marion RT, Razskazovskiy Y. The release of 5-methylene-2-furanone from irradiated DNA catalyzed by cationic polyamines and divalent metal cations. Radiat Res. 2005 Jan; 163(1):85-9.
    View in: PubMed
  21. Purkayastha S, Bernhard WA. What is the initial chemical precursor of DNA strand breaks generated by direct-type effects? J Phys Chem B. 2004 Nov 25; 108(47):18377-82.
    View in: PubMed
  22. Roginskaya M, Bernhard WA, Razskazovskiy Y. Diffusion Approach to Long Distance Charge Migration in DNA: Time-Dependent and Steady-State Analytical Solutions for the Product Yields. J Phys Chem B. 2004 Feb 19; 108(7):2432-7.
    View in: PubMed
  23. Razskazovskiy Y, Debije MG, Howerton SB, Williams LD, Bernhard WA. Strand breaks in X-irradiated crystalline DNA: alternating CG oligomers. Radiat Res. 2003 Sep; 160(3):334-9.
    View in: PubMed
  24. Razskazovskiy Y, Debije MG, Bernhard WA. Strand breaks produced in X-írradiated crystalline DNA: influence of base sequence. Radiat Res. 2003 May; 159(5):663-9.
    View in: PubMed
  25. Debije MG, Close DM, Bernhard WA. Reductive damage in directly ionized DNA: saturation of the C5=C6 bond of cytosine in d(CGCG)(2) crystals. Radiat Res. 2002 Mar; 157(3):235-42.
    View in: PubMed
  26. Debije MG, Bernhard WA. Electron paramagnetic resonance evidence for a C3' sugar radical in crystalline d(CTCTCGAGAG) X-irradiated at 4 K. Radiat Res. 2001 May; 155(5):687-92.
    View in: PubMed
  27. Debije MG, Razskazovskiy Y, Bernhard WA. The yield of strand breaks resulting from direct-type effects in crystalline DNA X-irradiated at 4 K and room temperature. J Am Chem Soc. 2001 Mar 28; 123(12):2917-8.
    View in: PubMed
  28. Debije MG, Strickler MD, Bernhard WA. On the efficiency of hole and electron transfer from the hydration layer to DNA: An EPR study of crystalline DNA X-irradiated at 4 K. Radiat Res. 2000 Aug; 154(2):163-70.
    View in: PubMed
  29. Razskazovskiy Y, Debije MG, Bernhard WA. Direct radiation damage to crystalline DNA: what is the source of unaltered base release? Radiat Res. 2000 Apr; 153(4):436-41.
    View in: PubMed
  30. Debije MG, Bernhard WA. Free radical yields in crystalline DNA X-irradiated at 4 K. Radiat Res. 1999 Dec; 152(6):583-9.
    View in: PubMed
  31. Milano MT, Bernhard WA. The influence of packing on free radical yields in solid-state DNA: film compared to lyophilized frozen solution. Radiat Res. 1999 Aug; 152(2):196-201.
    View in: PubMed
  32. Milano MT, Bernhard WA. The effect of packing and conformation on free radical yields in films of variably hydrated DNA. Radiat Res. 1999 Jan; 151(1):39-49.
    View in: PubMed
  33. Milano MT, Hu GG, Williams LD, Bernhard WA. Migration of electrons and holes in crystalline d(CGATCG)-anthracycline complexes X-irradiated at 4 K. Radiat Res. 1998 Jul; 150(1):101-14.
    View in: PubMed
  34. Mroczka NE, Mercer KR, Bernhard WA. The effects of lattice water on free radical yields in X-irradiated crystalline pyrimidines and purines: a low-temperature electron paramagnetic resonance investigation. Radiat Res. 1997 May; 147(5):560-8.
    View in: PubMed
  35. Mroczka NE, Bernhard WA. Electron paramagnetic resonance investigation of X-irradiated poly(U), poly(A) and poly(A):poly(U): influence of hydration, packing and conformation on radical yield at 4 K. Radiat Res. 1995 Dec; 144(3):251-7.
    View in: PubMed
  36. Barnes JP, Bernhard WA. The distribution of electron trapping in DNA: one-electron-reduced oligodeoxynucleotides of adenine and thymine. Radiat Res. 1995 Jul; 143(1):85-92.
    View in: PubMed
  37. Bernhard WA, Barnes J, Mercer KR, Mroczka N. The influence of packing on free radical yields in crystalline nucleic acids: the pyrimidine bases. Radiat Res. 1994 Nov; 140(2):199-214.
    View in: PubMed
  38. Bernhard WA, Mroczka N, Barnes J. Combination is the dominant free radical process initiated in DNA by ionizing radiation: an overview based on solid-state EPR studies. Int J Radiat Biol. 1994 Nov; 66(5):491-7.
    View in: PubMed
  39. Mroczka N, Bernhard WA. Hydration effects on free radical yields in DNA X-irradiated at 4 K. Radiat Res. 1993 Aug; 135(2):155-9.
    View in: PubMed
  40. Spalletta RA, Bernhard WA. Influence of primary structure on initial free radical products trapped in A:T polydeoxynucleotides X-irradiated at 4 K. Radiat Res. 1993 Feb; 133(2):143-50.
    View in: PubMed
  41. Spalletta RA, Bernhard WA. Free radical yields in A:T polydeoxynucleotides, oligodeoxynucleotides, and monodeoxynucleotides at 4 K. Radiat Res. 1992 Apr; 130(1):7-14.
    View in: PubMed
  42. Barnes J, Bernhard WA, Mercer KR. Distribution of electron trapping in DNA: protonation of one-electron reduced cytosine. Radiat Res. 1991 Apr; 126(1):104-7.
    View in: PubMed
  43. Bernhard WA, Patrzalek AZ. ESR characteristics of one-electron reduced thymine in monomer, oligomer, and polymer derivatives. Radiat Res. 1989 Mar; 117(3):379-94.
    View in: PubMed
  44. Bernhard WA. Free radicals formed by electron gain in oligomers of DNA. Free Radic Res Commun. 1989; 6(2-3):93-4.
    View in: PubMed
  45. Bernhard WA, Huttermann J, Close DM, Mercer KR. Free radicals trapped in methyl alpha-D-mannopyranoside X-irradiated at 77 K: an ESR/ENDOR study. Radiat Res. 1987 Oct; 112(1):54-61.
    View in: PubMed
  46. Radvany P, Pine M, Weintraub R, Abelmann WH, Bernhard WF. Mechanical circulatory support in postoperative cardiogenic shock. J Thorac Cardiovasc Surg. 1978 Jan; 75(1):97-103.
    View in: PubMed
  47. Hüttermann J, Haindl E, Schmidt G, Bernhard WA. A C5'-centred deoxyribose radical in single crystals of 5-chloro-and 5-bromodeoxyuridine X-irradiated at low temperatures. Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Nov; 32(5):431-8.
    View in: PubMed
  48. Bernhard WA, Hüttermann J, Müller A. A stable radical in the ribose moiety of X-irradiated 3'-cytidylic acid and its relation to a similar radical in cytidine: an ESR-ENDOR study. Radiat Res. 1976 Dec; 68(3):390-413.
    View in: PubMed
  49. Bernhard WA, Farley RA. ESR of hydrogen addition radicals in single crystals of 1-methylcytosine and 1-methyluracil. Radiat Res. 1976 May; 66(2):189-98.
    View in: PubMed
  50. Bernhard WA, Close DM, Mercer KR. ESR of x-irradiated single crystals of 3'-cytidylic acid: hydrogen abstraction from C5' of the sugar moiety. Radiat Res. 1976 Apr; 66(1):19-32.
    View in: PubMed
  51. Farley RA, Bernhard WA. Electron spin resonance of gamma- and x-irradiated nucleic acid base pairs. 1-Methylcytosine: 5-fluorouracil co-crystals at 77 degrees K. Radiat Res. 1975 Jan; 61(1):17-54.
    View in: PubMed
  52. Bernhard WA, Danyluk SS. Electron spin resonance studies of -irradiated dinucleotides and related compounds at 77 degrees K. Radiat Res. 1973 Feb; 53(2):169-80.
    View in: PubMed
  53. Snipes W, Bernhard W. Irradiation of dihydropyrimidines. Radiat Res. 1968 Jan; 33(1):162-73.
    View in: PubMed
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