Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Ann Chen Wu, M.D.

TitleAssistant Professor of Population Medicine
InstitutionHarvard Pilgrim Healthcare
DepartmentPopulation Medicine
AddressAmbulatory Care and Prevention
HMS/HPHC 6th Fl
133 Brookline Ave
Boston MA 02215
Phone617/509-9987

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Leyton JV, Olafsen T, Lepin EJ, Hahm S, Fonge H, Reiter RE, Wu AM. Positron Emission Tomographic Imaging of Iodine 124 Anti-Prostate Stem Cell Antigen-Engineered Antibody Fragments in LAPC-9 Tumor-Bearing Severe Combined Immunodeficiency Mice. Mol Imaging. 2013 May 1; 12(3):191-202.
    View in: PubMed
  2. Fu M, Brewer S, Olafsen T, Wu AM, Gordon LK, Said J, Braun J, Wadehra M. Positron Emission Tomography Imaging of Endometrial Cancer Using Engineered Anti-EMP2 Antibody Fragments. Mol Imaging Biol. 2013 Feb; 15(1):68-78.
    View in: PubMed
  3. Girgis MD, Olafsen T, Kenanova V, McCabe KE, Wu AM, Tomlinson JS. CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer. Int J Mol Imaging. 2011; 2011:834515.
    View in: PubMed
  4. Barat B, Kenanova VE, Olafsen T, Wu AM. Evaluation of two internalizing carcinoembryonic antigen reporter genes for molecular imaging. Mol Imaging Biol. 2011 Jun; 13(3):526-35.
    View in: PubMed
  5. Liu K, Lepin EJ, Wang MW, Guo F, Lin WY, Chen YC, Sirk SJ, Olma S, Phelps ME, Zhao XZ, Tseng HR, Michael van Dam R, Wu AM, Shen CK. Microfluidic-based 18F-labeling of biomolecules for immuno-positron emission tomography. Mol Imaging. 2011 Jun; 10(3):168-76, 1-7.
    View in: PubMed
  6. Morizono K, Xie Y, Olafsen T, Lee B, Dasgupta A, Wu AM, Chen IS. The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell Host Microbe. 2011 Apr 21; 9(4):286-98.
    View in: PubMed
  7. Girgis MD, Kenanova V, Olafsen T, McCabe KE, Wu AM, Tomlinson JS. Anti-CA19-9 diabody as a PET imaging probe for pancreas cancer. J Surg Res. 2011 Oct; 170(2):169-78.
    View in: PubMed
  8. Olafsen T, Young SG, Davies BS, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG. Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. J Biol Chem. 2010 Dec 10; 285(50):39239-48.
    View in: PubMed
  9. Kenanova VE, Olafsen T, Salazar FB, Williams LE, Knowles S, Wu AM. Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins. Protein Eng Des Sel. 2010 Oct; 23(10):789-98.
    View in: PubMed
  10. Wong JY, Raubitschek A, Yamauchi D, Williams LE, Wu AM, Yazaki P, Shively JE, Colcher D, Somlo G. A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer. Cancer Biother Radiopharm. 2010 Aug; 25(4):387-94.
    View in: PubMed
  11. McCabe KE, Wu AM. Positive progress in immunoPET--not just a coincidence. Cancer Biother Radiopharm. 2010 Jun; 25(3):253-61.
    View in: PubMed
  12. Olafsen T, Wu AM. Antibody vectors for imaging. Semin Nucl Med. 2010 May; 40(3):167-81.
    View in: PubMed
  13. Aweda TA, Beck HE, Wu AM, Wei LH, Weber WA, Meares CF. Rates and equilibria for probe capture by an antibody with infinite affinity. Bioconjug Chem. 2010 Apr 21; 21(4):784-91.
    View in: PubMed
  14. Lepin EJ, Leyton JV, Zhou Y, Olafsen T, Salazar FB, McCabe KE, Hahm S, Marks JD, Reiter RE, Wu AM. An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors. Eur J Nucl Med Mol Imaging. 2010 Aug; 37(8):1529-38.
    View in: PubMed
  15. Wu AC, Lasky-Su J, Rogers CA, Klanderman BJ, Litonjua A. Polymorphisms of chitinases are not associated with asthma. J Allergy Clin Immunol. 2010 Mar; 125(3):754-7, 757.e1-757.e2.
    View in: PubMed
  16. Sherman DJ, Kenanova VE, Lepin EJ, McCabe KE, Kamei K, Ohashi M, Wang S, Tseng HR, Wu AM, Behrenbruch CP. A differential cell capture assay for evaluating antibody interactions with cell surface targets. Anal Biochem. 2010 Jun 15; 401(2):173-81.
    View in: PubMed
  17. Wu AC, Himes BE, Lasky-Su J, Litonjua A, Li L, Lange C, Lima J, Irvin CG, Weiss ST. Development of a Pharmacogenetic Predictive Test in asthma: proof of concept. Pharmacogenet Genomics. 2010 Feb; 20(2):86-93.
    View in: PubMed
  18. Olafsen T, Sirk SJ, Betting DJ, Kenanova VE, Bauer KB, Ladno W, Raubitschek AA, Timmerman JM, Wu AM. ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies). Protein Eng Des Sel. 2010 Apr; 23(4):243-9.
    View in: PubMed
  19. Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung CW, Kassa T, Metz MZ, Kim SU, Glackin CA, Wu AM, Yazaki PJ, Aboody KS. Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies. PLoS One. 2009; 4(12):e8314.
    View in: PubMed
  20. Afshar S, Olafsen T, Wu AM, Morrison SL. Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT. J Exp Clin Cancer Res. 2009; 28:147.
    View in: PubMed
  21. Himes BE, Wu AC, Duan QL, Klanderman B, Litonjua AA, Tantisira K, Ramoni MF, Weiss ST. Predicting response to short-acting bronchodilator medication using Bayesian networks. Pharmacogenomics. 2009 Sep; 10(9):1393-412.
    View in: PubMed
  22. Olafsen T, Betting D, Kenanova VE, Salazar FB, Clarke P, Said J, Raubitschek AA, Timmerman JM, Wu AM. Recombinant anti-CD20 antibody fragments for small-animal PET imaging of B-cell lymphomas. J Nucl Med. 2009 Sep; 50(9):1500-8.
    View in: PubMed
  23. Vaidyanathan G, Jestin E, Olafsen T, Wu AM, Zalutsky MR. Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. Nucl Med Biol. 2009 Aug; 36(6):671-80.
    View in: PubMed
  24. Barat B, Sirk SJ, McCabe KE, Li J, Lepin EJ, Remenyi R, Koh AL, Olafsen T, Gambhir SS, Weiss S, Wu AM. Cys-diabody quantum dot conjugates (immunoQdots) for cancer marker detection. Bioconjug Chem. 2009 Aug 19; 20(8):1474-81.
    View in: PubMed
  25. Wu AC, Glauber J, Gay C, Lieu TA. Asthma self-assessment in a Medicaid population. BMC Public Health. 2009; 9:244.
    View in: PubMed
  26. Wu AC, Li L, Miroshnik I, Glauber J, Gay C, Lieu TA. Outcomes after periodic use of inhaled corticosteroids in children. J Asthma. 2009 Jun; 46(5):517-22.
    View in: PubMed
  27. Zheng C, Zhang Y, Liu Y, Wu A, Xia L, Zeng J, Liu J, Qiu G. Characterization and reconstitute of a [Fe4S4] adenosine 5'-phosphosulfate reductase from Acidithiobacillus ferrooxidans. Curr Microbiol. 2009 Jun; 58(6):586-92.
    View in: PubMed
  28. Shimazaki K, Chan AM, Moniz RJ, Wadehra M, Nagy A, Coulam CP, Mareninov S, Lepin EM, Wu AM, Kelly KA, Braun J, Gordon LK. Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model. FEMS Immunol Med Microbiol. 2009 Mar; 55(2):240-9.
    View in: PubMed
  29. Schipper ML, Iyer G, Koh AL, Cheng Z, Ebenstein Y, Aharoni A, Keren S, Bentolila LA, Li J, Rao J, Chen X, Banin U, Wu AM, Sinclair R, Weiss S, Gambhir SS. Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small. 2009 Jan; 5(1):126-34.
    View in: PubMed
  30. Wu AM. Antibodies and antimatter: the resurgence of immuno-PET. J Nucl Med. 2009 Jan; 50(1):2-5.
    View in: PubMed
  31. Wu AC, Tantisira K, Li L, Schuemann B, Weiss S. Repeatability of response to asthma medications. J Allergy Clin Immunol. 2009 Feb; 123(2):385-90.
    View in: PubMed
  32. Sirk SJ, Olafsen T, Barat B, Bauer KB, Wu AM. Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2. Bioconjug Chem. 2008 Dec; 19(12):2527-34.
    View in: PubMed
  33. Shimazaki K, Lepin EJ, Wei B, Nagy AK, Coulam CP, Mareninov S, Fu M, Wu AM, Marks JD, Braun J, Gordon LK, Wadehra M. Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines. Clin Cancer Res. 2008 Nov 15; 14(22):7367-77.
    View in: PubMed
  34. Leyton JV, Olafsen T, Lepin EJ, Hahm S, Bauer KB, Reiter RE, Wu AM. Humanized radioiodinated minibody for imaging of prostate stem cell antigen-expressing tumors. Clin Cancer Res. 2008 Nov 15; 14(22):7488-96.
    View in: PubMed
  35. Leyton JV, Olafsen T, Sherman MA, Bauer KB, Aghajanian P, Reiter RE, Wu AM. Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors. Protein Eng Des Sel. 2009 Mar; 22(3):209-16.
    View in: PubMed
  36. Wei LH, Olafsen T, Radu C, Hildebrandt IJ, McCoy MR, Phelps ME, Meares C, Wu AM, Czernin J, Weber WA. Engineered antibody fragments with infinite affinity as reporter genes for PET imaging. J Nucl Med. 2008 Nov; 49(11):1828-35.
    View in: PubMed
  37. Kenanova V, Barat B, Olafsen T, Chatziioannou A, Herschman HR, Braun J, Wu AM. Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging. Eur J Nucl Med Mol Imaging. 2009 Jan; 36(1):104-14.
    View in: PubMed
  38. Wu AC, Li L, Miroshnik I, Glauber J, Gay C, Lieu TA. Outcomes after periodic use of inhaled corticosteroids in children. Journal of Asthma. 2008; in press.
  39. Brown RH, Irvin CG, Allen GB, Shapiro SD, Martin WJ, Kolb MR, Hyde DM, Nieman GF, Cody DD, Ishii M, Kadlecek SJ, Driehuys B, Rizi RR, Wu AM, Weber WA, Stout DB. An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology. Proc Am Thorac Soc. 2008 Jul 15; 5(5):591-600.
    View in: PubMed
  40. Wu AC, Fuhlbrigge AL. Economic evaluation of pharmacogenetic tests. Clin Pharmacol Ther. 2008 Aug; 84(2):272-4.
    View in: PubMed
  41. Wu AM, Olafsen T. Antibodies for molecular imaging of cancer. Cancer J. 2008 May-Jun; 14(3):191-7.
    View in: PubMed
  42. Wu AC, Gillman MW, Taveras EM, Weiss ST, Litonjua AA. INSIG2 is associated with lower gain in weight-for-length between birth and age 6 months. BMC Pediatrics. 2008; under review..
  43. Wu AC, Smith L, Bokhour B, Hohman K, Lieu TA . Racial/ethnic variation in parent perceptions of asthma. Ambulatory Pediatrics. 2008; 17;8(2):89-97.
  44. Wu AC, Smith L, Bokhour B, Hohman KH, Lieu TA. Racial/Ethnic variation in parent perceptions of asthma. Ambul Pediatr. 2008 Mar-Apr; 8(2):89-97.
    View in: PubMed
  45. Wu AC, Tantisira K, Li L, Schuemann B, Weiss S. Heritability of response to asthma medications. Pediatric Academic Societies Annual Meeting. 2008.
  46. Wu AC, Paltiel AD,l Kuntz KM, Weiss ST, Fuhlbrigge AL. . Omalizumab unlikely cost-effective based on Asthma Policy Model. Journal of Allergy and Clinical Immunology. 2008; in press.
  47. Wu AC, Wisler-Sher DJ, Griswold K, Colson E, Shapiro ED, Holmboe ES, Benin AL. Postpartum mothers' attitudes, knowledge, and trust regarding vaccination. Matern Child Health J. 2008 Nov; 12(6):766-73.
    View in: PubMed
  48. Wu AC, Paltiel AD, Kuntz KM, Weiss ST, Fuhlbrigge AL. Cost-effectiveness of omalizumab in adults with severe asthma: results from the Asthma Policy Model. J Allergy Clin Immunol. 2007 Nov; 120(5):1146-52.
    View in: PubMed
  49. Venisnik KM, Olafsen T, Gambhir SS, Wu AM. Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging. Mol Imaging Biol. 2007 Sep-Oct; 9(5):267-77.
    View in: PubMed
  50. Schipper ML, Cheng Z, Lee SW, Bentolila LA, Iyer G, Rao J, Chen X, Wu AM, Weiss S, Gambhir SS. microPET-based biodistribution of quantum dots in living mice. J Nucl Med. 2007 Sep; 48(9):1511-8.
    View in: PubMed
  51. Loening AM, Wu AM, Gambhir SS. Red-shifted Renilla reniformis luciferase variants for imaging in living subjects. Nat Methods. 2007 Aug; 4(8):641-3.
    View in: PubMed
  52. Olafsen T, Gu Z, Sherman MA, Leyton JV, Witkosky ME, Shively JE, Raubitschek AA, Morrison SL, Wu AM, Reiter RE. Targeting, imaging, and therapy using a humanized antiprostate stem cell antigen (PSCA) antibody. J Immunother. 2007 May-Jun; 30(4):396-405.
    View in: PubMed
  53. Barat B, Wu AM. Metabolic biotinylation of recombinant antibody by biotin ligase retained in the endoplasmic reticulum. Biomol Eng. 2007 Sep; 24(3):283-91.
    View in: PubMed
  54. Cai W, Olafsen T, Zhang X, Cao Q, Gambhir SS, Williams LE, Wu AM, Chen X. PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody. J Nucl Med. 2007 Feb; 48(2):304-10.
    View in: PubMed
  55. Kenanova V, Olafsen T, Williams LE, Ruel NH, Longmate J, Yazaki PJ, Shively JE, Colcher D, Raubitschek AA, Wu AM. Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy. Cancer Res. 2007 Jan 15; 67(2):718-26.
    View in: PubMed
  56. Wu AC, Smith L, Bohkour B, Hohman K, Lieu TA. Racial/ethnic variations in perceptions of asthma. Pediatric Academic Societies Annual Meeting. 2007.
  57. Wu AC, Leventhal JM, Ortiz J, Gonzalez EE, Forsyth B. The interpreter as cultural educator of residents: improving communication for Latino parents. Arch Pediatr Adolesc Med. 2006 Nov; 160(11):1145-50.
    View in: PubMed
  58. Sui G, Wang J, Lee CC, Lu W, Lee SP, Leyton JV, Wu AM, Tseng HR. Solution-phase surface modification in intact poly(dimethylsiloxane) microfluidic channels. Anal Chem. 2006 Aug 1; 78(15):5543-51.
    View in: PubMed
  59. Venisnik KM, Olafsen T, Loening AM, Iyer M, Gambhir SS, Wu AM. Bifunctional antibody-Renilla luciferase fusion protein for in vivo optical detection of tumors. Protein Eng Des Sel. 2006 Oct; 19(10):453-60.
    View in: PubMed
  60. Loening AM, Fenn TD, Wu AM, Gambhir SS. Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output. Protein Eng Des Sel. 2006 Sep; 19(9):391-400.
    View in: PubMed
  61. Ferl GZ, Kenanova V, Wu AM, DiStefano JJ. A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments. Mol Cancer Ther. 2006 Jun; 5(6):1550-8.
    View in: PubMed
  62. Wong JY, Chu DZ, Williams LE, Liu A, Zhan J, Yamauchi DM, Wilczynski S, Wu AM, Yazaki PJ, Shively JE, Leong L, Raubitschek AA. A phase I trial of (90)Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies. Cancer Biother Radiopharm. 2006 Apr; 21(2):88-100.
    View in: PubMed
  63. Li L, Yazaki PJ, Anderson AL, Crow D, Colcher D, Wu AM, Williams LE, Wong JY, Raubitschek A, Shively JE. Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody. Bioconjug Chem. 2006 Jan-Feb; 17(1):68-76.
    View in: PubMed
  64. Olafsen T, Kenanova VE, Wu AM. Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment. Nat Protoc. 2006; 1(4):2048-60.
    View in: PubMed
  65. Wu AC, Leventhal JM, Ortiz J, Gonzalez EE, Forsyth B . The interpreter as interactive teacher of residents: Improving communication for Latino patients. Archives of Pediatrics and Adolescent Medicine. 2006; 160:1145-50.
  66. Kenanova V, Wu AM. Tailoring antibodies for radionuclide delivery. Expert Opin Drug Deliv. 2006 Jan; 3(1):53-70.
    View in: PubMed
  67. Ferl GZ, Wu AM, DiStefano JJ. A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn). Ann Biomed Eng. 2005 Nov; 33(11):1640-52.
    View in: PubMed
  68. Huang SC, Truong D, Wu HM, Chatziioannou AF, Shao W, Wu AM, Phelps ME. An internet-based "kinetic imaging system" (KIS) for MicroPET. Mol Imaging Biol. 2005 Sep-Oct; 7(5):330-41.
    View in: PubMed
  69. Wu AM, Senter PD. Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol. 2005 Sep; 23(9):1137-46.
    View in: PubMed
  70. Ullrich C, Wu A, Armsby C, Rieber S, Wingerter S, Brugnara C, Shapiro D, Bernstein H. Screening healthy infants for iron deficiency using reticulocyte hemoglobin content. JAMA. 2005 Aug 24; 294(8):924-30.
    View in: PubMed
  71. Olafsen T, Kenanova VE, Sundaresan G, Anderson AL, Crow D, Yazaki PJ, Li L, Press MF, Gambhir SS, Williams LE, Wong JY, Raubitschek AA, Shively JE, Wu AM. Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging. Cancer Res. 2005 Jul 1; 65(13):5907-16.
    View in: PubMed
  72. Bentolila LA, Michalet X, Pinaud FF, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S. Quantum dots for molecular imaging and cancer medicine. Discov Med. 2005 Apr; 5(26):213-8.
    View in: PubMed
  73. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S. Quantum dots for live cells, in vivo imaging, and diagnostics. Science. 2005 Jan 28; 307(5709):538-44.
    View in: PubMed
  74. Kenanova V, Olafsen T, Crow DM, Sundaresan G, Subbarayan M, Carter NH, Ikle DN, Yazaki PJ, Chatziioannou AF, Gambhir SS, Williams LE, Shively JE, Colcher D, Raubitschek AA, Wu AM. Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments. Cancer Res. 2005 Jan 15; 65(2):622-31.
    View in: PubMed
  75. Wu AC, Wisler-Scher DJ, Griswold K, Colson E, Shapiro ED, Holmboe E, Benin AL. . Mothers' attitudes about vaccination. Pediatric Academic Societies Annual Meeting. 2005; 57(853).
  76. Wu AC, Forsyth B. . The interpreter as interactive resident teacher makes a difference for Latino patients. Pediatric Academic Societies Annual Meeting. 2005; 57(832).
  77. Benin AL, Wu AC, Holmboe E, Shapiro, ED, Anyan W. . Communication about vaccines for teenagers: A qualitative study with teens and their parents. Pediatric Academic Societies Annual Meeting. 2005; 57(1803).
  78. Bhat AH, Corbett VN, Liu R, Carpenter ND, Liu NW, Wu AM, Hopkins GD, Li X, Sahn DJ. Validation of volume and mass assessments for human fetal heart imaging by 4-dimensional spatiotemporal image correlation echocardiography: in vitro balloon model experiments. J Ultrasound Med. 2004 Sep; 23(9):1151-9.
    View in: PubMed
  79. Bhat AH, Corbett V, Carpenter N, Liu N, Liu R, Wu A, Hopkins G, Sohaey R, Winkler C, Sahn CS, Sovinsky V, Li X, Sahn DJ. Fetal ventricular mass determination on three-dimensional echocardiography: studies in normal fetuses and validation experiments. Circulation. 2004 Aug 31; 110(9):1054-60.
    View in: PubMed
  80. Yazaki PJ, Sherman MA, Shively JE, Ikle D, Williams LE, Wong JY, Colcher D, Wu AM, Raubitschek AA. Humanization of the anti-CEA T84.66 antibody based on crystal structure data. Protein Eng Des Sel. 2004 May; 17(5):481-9.
    View in: PubMed
  81. Wong JY, Chu DZ, Williams LE, Yamauchi DM, Ikle DN, Kwok CS, Liu A, Wilczynski S, Colcher D, Yazaki PJ, Shively JE, Wu AM, Raubitschek AA. Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer. Clin Cancer Res. 2004 Aug 1; 10(15):5014-21.
    View in: PubMed
  82. Olafsen T, Tan GJ, Cheung CW, Yazaki PJ, Park JM, Shively JE, Williams LE, Raubitschek AA, Press MF, Wu AM. Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting. Protein Eng Des Sel. 2004 Apr; 17(4):315-23.
    View in: PubMed
  83. Olafsen T, Cheung CW, Yazaki PJ, Li L, Sundaresan G, Gambhir SS, Sherman MA, Williams LE, Shively JE, Raubitschek AA, Wu AM. Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications. Protein Eng Des Sel. 2004 Jan; 17(1):21-7.
    View in: PubMed
  84. Wu AM. Engineering multivalent antibody fragments for in vivo targeting. Methods Mol Biol. 2004; 248:209-25.
    View in: PubMed
  85. Yazaki PJ, Wu AM. Expression of recombinant antibodies in mammalian cell lines. Methods Mol Biol. 2004; 248:255-68.
    View in: PubMed
  86. Sundaresan G, Yazaki PJ, Shively JE, Finn RD, Larson SM, Raubitschek AA, Williams LE, Chatziioannou AF, Gambhir SS, Wu AM. 124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice. J Nucl Med. 2003 Dec; 44(12):1962-9.
    View in: PubMed
  87. Wong JY, Shibata S, Williams LE, Kwok CS, Liu A, Chu DZ, Yamauchi DM, Wilczynski S, Ikle DN, Wu AM, Yazaki PJ, Shively JE, Doroshow JH, Raubitschek AA. A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer. Clin Cancer Res. 2003 Dec 1; 9(16 Pt 1):5842-52.
    View in: PubMed
  88. Ye JJ, Liang SJ, Guo N, Li SL, Wu AM, Giannini S, Sachdev D, Yee D, Brünner N, Ikle D, Fujita-Yamaguchi Y. Combined effects of tamoxifen and a chimeric humanized single chain antibody against the type I IGF receptor on breast tumor growth in vivo. Horm Metab Res. 2003 Nov-Dec; 35(11-12):836-42.
    View in: PubMed
  89. Ray P, Wu AM, Gambhir SS. Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice. Cancer Res. 2003 Mar 15; 63(6):1160-5.
    View in: PubMed
  90. Carmichael JA, Power BE, Garrett TP, Yazaki PJ, Shively JE, Raubischek AA, Wu AM, Hudson PJ. The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility. J Mol Biol. 2003 Feb 14; 326(2):341-51.
    View in: PubMed
  91. Jensen MC, Cooper LJ, Wu AM, Forman SJ, Raubitschek A. Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy. Cytotherapy. 2003; 5(2):131-8.
    View in: PubMed
  92. Yazaki PJ, Wu AM. Construction and characterization of minibodies for imaging and therapy of colorectal carcinomas. Methods Mol Biol. 2003; 207:351-64.
    View in: PubMed
  93. Li L, Olafsen T, Anderson AL, Wu A, Raubitschek AA, Shively JE. Reduction of kidney uptake in radiometal labeled peptide linkers conjugated to recombinant antibody fragments. Site-specific conjugation of DOTA-peptides to a Cys-diabody. Bioconjug Chem. 2002 Sep-Oct; 13(5):985-95.
    View in: PubMed
  94. Wu AC, Lesperance L, Bernstein H. Screening for iron deficiency. Pediatr Rev. 2002 May; 23(5):171-8.
    View in: PubMed
  95. Wu A, Lesperance L, Bernstein H. . Screening for iron deficiency. Pediatrics in Review. 2002; 23(5).
  96. Lesperance L, Wu A, Bernstein H. . Iron deficiency in children. Contemporary Pediatrics. 2002.
  97. Wu AM, Tan GJ, Sherman MA, Clarke P, Olafsen T, Forman SJ, Raubitschek AA. Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange. Protein Eng. 2001 Dec; 14(12):1025-33.
    View in: PubMed
  98. Yazaki PJ, Shively L, Clark C, Cheung CW, Le W, Szpikowska B, Shively JE, Raubitschek AA, Wu AM. Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications. J Immunol Methods. 2001 Jul 1; 253(1-2):195-208.
    View in: PubMed
  99. Wu AM. Tools for pretargeted radioimmunotherapy. Cancer Biother Radiopharm. 2001 Apr; 16(2):103-8.
    View in: PubMed
  100. Yazaki PJ, Wu AM, Tsai SW, Williams LE, Ikler DN, Wong JY, Shively JE, Raubitschek AA. Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments. Bioconjug Chem. 2001 Mar-Apr; 12(2):220-8.
    View in: PubMed
  101. Williams LE, Wu AM, Yazaki PJ, Liu A, Raubitschek AA, Shively JE, Wong JY. Numerical selection of optimal tumor imaging agents with application to engineered antibodies. Cancer Biother Radiopharm. 2001 Feb; 16(1):25-35.
    View in: PubMed
  102. Chen A, Armsby L, Shapiro D, Brugnara C, Bernstein H. Reticulocyte hemoglobin content (CHr) in healthy infants. Pediatric Academic Societies Annual Meeting. 2001; (899).
  103. Chu DZ, Yamauchi DM, Williams LE, Liu A, Wilczynski S, Wu AM, Shively JE, Doroshow JH, Raubitschek AA. A phase I radioimmunotherapy trial evaluating 90yttrium-labeled anti-carcinoembryonic antigen (CEA) chimeric T84.66 in patients with metastatic CEA-producing malignancies. Clin Cancer Res. 2000 Oct; 6(10):3855-63.
    View in: PubMed
  104. Wu AM, Yazaki PJ. Designer genes: recombinant antibody fragments for biological imaging. Q J Nucl Med. 2000 Sep; 44(3):268-83.
    View in: PubMed
  105. Wu AM, Yazaki PJ, Tsai Sw, Nguyen K, Anderson AL, McCarthy DW, Welch MJ, Shively JE, Williams LE, Raubitschek AA, Wong JY, Toyokuni T, Phelps ME, Gambhir SS. High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8495-500.
    View in: PubMed
  106. Li SL, Liang SJ, Guo N, Wu AM, Fujita-Yamaguchi Y. Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth. Cancer Immunol Immunother. 2000 Jul; 49(4-5):243-52.
    View in: PubMed
  107. Williams LE, Liu A, Wu AM, Yazaki PJ, Yamauchi DM, Lopatin G, Raubitschek AA, Wong JY. Truncation of blood curves to enhance imaging and therapy with monoclonal antibodies. Med Phys. 2000 May; 27(5):988-94.
    View in: PubMed
  108. Tsai SW, Sun Y, Williams LE, Raubitschek AA, Wu AM, Shively JE. Biodistribution and radioimmunotherapy of human breast cancer xenografts with radiometal-labeled DOTA conjugated anti-HER2/neu antibody 4D5. Bioconjug Chem. 2000 May-Jun; 11(3):327-34.
    View in: PubMed
  109. Jensen MC, Clarke P, Tan G, Wright C, Chung-Chang W, Clark TN, Zhang F, Slovak ML, Wu AM, Forman SJ, Raubitschek A. Human T lymphocyte genetic modification with naked DNA. Mol Ther. 2000 Jan; 1(1):49-55.
    View in: PubMed
  110. Wu AM, Wu JH, Chen Y, Tsai M, Herp A. Forssman pentasaccharide and polyvalent Galbeta1-->4GlcNAc as major ligands with affinity for Caragana arborescens agglutinin. FEBS Lett. 1999 Dec 17; 463(3):225-30.
    View in: PubMed
  111. Wong JY, Somlo G, Odom-Maryon T, Williams LE, Liu A, Yamauchi D, Wu AM, Yazaki P, Wilczynski S, Shively JE, Forman S, Doroshow JH, Raubitschek AA. Initial clinical experience evaluating Yttrium-90-chimeric T84.66 anticarcinoembryonic antigen antibody and autologous hematopoietic stem cell support in patients with carcinoembryonic antigen-producing metastatic breast cancer. Clin Cancer Res. 1999 Oct; 5(10 Suppl):3224s-3231s.
    View in: PubMed
  112. Chen A, Adams JM, Smith EO, Weisman LE. . The incidence of necrotizing enterocolitis (NEC) is increased following surgical ligation versus indomethacin treatment of a patent ductus arteriosus (PDA). Pediatric Academic Societies Annual Meeting. 1999; (1412).
  113. Chen A, Zaidi AK, Mueller BU, Huskins WC, Perez-Atayde AR, McIntosh K. . Pneumocystis carinii presenting as a mediastinal mass in a child with acquired immunodeficiency syndrome. Pediatrics Infectious Disease Journal. 1999; 18:827-31.
  114. Wong JY, Chu DZ, Yamauchi D, Odom-Maryon TL, Williams LE, Liu A, Esteban JM, Wu AM, Primus FJ, Beatty JD, Shively JE, Raubitschek AA. Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients. J Nucl Med. 1998 Dec; 39(12):2097-104.
    View in: PubMed
  115. You YH, Hefta LJ, Yazaki PJ, Wu AM, Shively JE. Expression, purification, and characterization of a two domain carcinoembryonic antigen minigene (N-A3) in pichia pastoris. The essential role of the N-domain. Anticancer Res. 1998 Sep-Oct; 18(5A):3193-201.
    View in: PubMed
  116. Jensen M, Tan G, Forman S, Wu AM, Raubitschek A. CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy. Biol Blood Marrow Transplant. 1998; 4(2):75-83.
    View in: PubMed
  117. Wong JY, Thomas GE, Yamauchi D, Williams LE, Odom-Maryon TL, Liu A, Esteban JM, Neumaier M, Dresse S, Wu AM, Primus FJ, Shively JE, Raubitschek AA. Clinical evaluation of indium-111-labeled chimeric anti-CEA monoclonal antibody. J Nucl Med. 1997 Dec; 38(12):1951-9.
    View in: PubMed
  118. Hu S, Shively L, Raubitschek A, Sherman M, Williams LE, Wong JY, Shively JE, Wu AM. Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts. Cancer Res. 1996 Jul 1; 56(13):3055-61.
    View in: PubMed
  119. Wu AM, Chen W, Raubitschek A, Williams LE, Neumaier M, Fischer R, Hu SZ, Odom-Maryon T, Wong JY, Shively JE. Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers. Immunotechnology. 1996 Feb; 2(1):21-36.
    View in: PubMed
  120. Williams LE, Liu A, Wu AM, Odom-Maryon T, Chai A, Raubitschek AA, Wong JY. Figures of merit (FOMs) for imaging and therapy using monoclonal antibodies. Med Phys. 1995 Dec; 22(12):2025-7.
    View in: PubMed
  121. Wong JY, Williams LE, Yamauchi DM, Odom-Maryon T, Esteban JM, Neumaier M, Wu AM, Johnson DK, Primus FJ, Shively JE, et al. Initial experience evaluating 90yttrium-radiolabeled anti-carcinoembryonic antigen chimeric T84.66 in a phase I radioimmunotherapy trial. Cancer Res. 1995 Dec 1; 55(23 Suppl):5929s-5934s.
    View in: PubMed
  122. Reers M, Smiley ST, Mottola-Hartshorn C, Chen A, Lin M, Chen LB . Mitochondrial membrane potential monitored by JC-1 dye. Methods in Enzymology. 1995; 260:406-17.
  123. Gu ZM, Ji YQ, Wu AM, Yang JH. [Review of the original texts on wujia (Cortex Acanthopanacis)]. Zhongguo Zhong Yao Za Zhi. 1993 Mar; 18(3):131-2, 189.
    View in: PubMed
  124. Ehsani A, Low J, Wallace RB, Wu AM. Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization. Genomics. 1993 Feb; 15(2):426-9.
    View in: PubMed
  125. Kashani-Sabet M, Funato T, Tone T, Jiao L, Wang W, Yoshida E, Kashfinn BI, Shitara T, Wu AM, Moreno JG, et al. Reversal of the malignant phenotype by an anti-ras ribozyme. Antisense Res Dev. 1992; 2(1):3-15.
    View in: PubMed
  126. Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW, Steele GD, Chen LB. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proceedings of the National Academy of Sciences of the USA. 1991; 88(9):3671-5.
  127. Wu AM, Winberg CD, Sheibani K, Colombero AM, Wallace RB, Rappaport H. Genotype and phenotype: a practical approach to the immunogenetic analysis of lymphoproliferative disorders. Hum Pathol. 1990 Nov; 21(11):1132-41.
    View in: PubMed
  128. Wu AM, Ben-Ezra J, Winberg C, Colombero AM, Rappaport H. Analysis of antigen receptor gene rearrangements in ethanol and formaldehyde-fixed, paraffin-embedded specimens. Lab Invest. 1990 Jul; 63(1):107-14.
    View in: PubMed
  129. Traweek ST, Sheibani K, Winberg CD, Mena RR, Wu AM, Rappaport H. Monocytoid B-cell lymphoma: its evolution and relationship to other low-grade B-cell neoplasms. Blood. 1989 Feb; 73(2):573-8.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Wu's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (484) concept(s)
_
Co-Authors
See all (15) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_