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Tadanori Mammoto, Ph.D., M.D.

TitleInstructor in Surgery
InstitutionChildren's Hospital Boston
DepartmentSurgery
AddressChildrens Hospital
Karp Research Bldg. 11th floor
300 Longwood Ave
Boston MA 02115
Phone617/667-3404

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mammoto T, Jiang E, Jiang A, Mammoto A. Extracellular Matrix Structure and Tissue Stiffness Control Postnatal Lung Development through the Lipoprotein Receptor-Related Protein 5/Tie2 Signaling System. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1009-18.
    View in: PubMed
  2. Mammoto T, Mammoto A, Ingber DE. Mechanobiology and developmental control. Annu Rev Cell Dev Biol. 2013 Oct 6; 29:27-61.
    View in: PubMed
  3. Mammoto T, Jiang E, Jiang A, Lu Y, Juan AM, Chen J, Mammoto A. Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering tie2 expression. PLoS One. 2013; 8(9):e73407.
    View in: PubMed
  4. Bischof AG, Yüksel D, Mammoto T, Mammoto A, Krause S, Ingber DE. Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. Integr Biol (Camb). 2013 Aug 22; 5(8):1045-56.
    View in: PubMed
  5. Mammoto T, Jiang A, Jiang E, Panigrahy D, Kieran MW, Mammoto A. Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. Am J Pathol. 2013 Oct; 183(4):1293-305.
    View in: PubMed
  6. Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13528-33.
    View in: PubMed
  7. Mammoto T, Jiang A, Jiang E, Mammoto A. Platelet rich plasma extract promotes angiogenesis through the angiopoietin1-Tie2 pathway. Microvasc Res. 2013 Sep; 89:15-24.
    View in: PubMed
  8. Mammoto A, Mammoto T, Kanapathipillai M, Wing Yung C, Jiang E, Jiang A, Lofgren K, Gee EP, Ingber DE. Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics. Nat Commun. 2013 Apr 23; 4:1759.
    View in: PubMed
  9. Mammoto T, Chen J, Jiang E, Jiang A, Smith LE, Ingber DE, Mammoto A. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One. 2012; 7(7):e41596.
    View in: PubMed
  10. Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science. 2012 Aug 10; 337(6095):738-42.
    View in: PubMed
  11. Mammoto A, Mammoto T, Ingber DE. Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci. 2012 Jul 1; 125(Pt 13):3061-73.
    View in: PubMed
  12. Kanapathipillai M, Mammoto A, Mammoto T, Kang JH, Jiang E, Ghosh K, Korin N, Gibbs A, Mannix R, Ingber DE. Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. Nano Lett. 2012 Jun 13; 12(6):3213-7.
    View in: PubMed
  13. O'Connell DJ, Ho JW, Mammoto T, Turbe-Doan A, O'Connell JT, Haseley PS, Koo S, Kamiya N, Ingber DE, Park PJ, Maas RL. A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis. Sci Signal. 2012 Jan 10; 5(206):ra4.
    View in: PubMed
  14. Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio JA, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D'Amore PA, Kieran MW, Zeldin DC. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest. 2012 Jan 3; 122(1):178-91.
    View in: PubMed
  15. Mammoto T, Mammoto A, Torisawa YS, Tat T, Gibbs A, Derda R, Mannix R, de Bruijn M, Yung CW, Huh D, Ingber DE. Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell. 2011 Oct 18; 21(4):758-69.
    View in: PubMed
  16. Mammoto T, Ingber DE. Mechanical control of tissue and organ development. Development. 2010 May; 137(9):1407-20.
    View in: PubMed
  17. Derda R, Laromaine A, Mammoto A, Tang SK, Mammoto T, Ingber DE, Whitesides GM. Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44):18457-62.
    View in: PubMed
  18. Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8.
    View in: PubMed
  19. Mammoto A, Mammoto T, Ingber DE. Rho signaling and mechanical control of vascular development. Curr Opin Hematol. 2008 May; 15(3):228-34.
    View in: PubMed
  20. Mammoto A, Sero JE, Mammoto T, Ingber DE. Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix. Methods Enzymol. 2008; 443:227-59.
    View in: PubMed
  21. Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007 Aug 17; 282(33):23910-8.
    View in: PubMed
  22. Yuan HT, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme VP, Woolf AS, Karumanchi SA. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB J. 2007 Oct; 21(12):3171-83.
    View in: PubMed
  23. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006 Jun; 12(6):642-9.
    View in: PubMed
  24. Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 2006 Mar; 3(3):e46.
    View in: PubMed
  25. Hanai J, Mammoto T, Seth P, Mori K, Karumanchi SA, Barasch J, Sukhatme VP. Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. J Biol Chem. 2005 Apr 8; 280(14):13641-7.
    View in: PubMed
  26. Kuri M, Kambara N, Baba M, Nakagawa M, Mammoto T, Tanigami H, Kishi Y. [Short-term bed rest as a cause of deep vein thrombosis in a patient with a huge abdominal tumor]. Masui. 2004 Feb; 53(2):191-4.
    View in: PubMed
  27. Feinberg MW, Watanabe M, Lebedeva MA, Depina AS, Hanai J, Mammoto T, Frederick JP, Wang XF, Sukhatme VP, Jain MK. Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. J Biol Chem. 2004 Apr 16; 279(16):16388-93.
    View in: PubMed
  28. Kita T, Mammoto T, Taniguchi H, Yamasaki K, Kishi Y. Diabetes attenuates the hemodynamic stabilizing effects of oral clonidine during off-pump coronary artery bypass surgery. J Clin Anesth. 2003 Nov; 15(7):520-4.
    View in: PubMed
  29. Morisaki A, Yamanaka Y, Mammoto T, Tanigami H, Kishi Y. [A case of silent rupture of a cerebral arteriovenous malformation during laparotomy]. Masui. 2003 Oct; 52(10):1083-5.
    View in: PubMed
  30. Baba M, Nakagawa M, Kuri M, Taniguchi H, Mammoto T, Kanbara N, Sakai T, Kishi Y. [Anesthetic management of a patient with squeezed heart by huge sternal tumor]. Masui. 2003 Jul; 52(7):759-61.
    View in: PubMed
  31. Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003 Jul; 9(7):964-8.
    View in: PubMed
  32. Kambara N, Kishi Y, Taniguchi H, Nakagawa M, Mammoto T, Tanigami H, Sakai T, Imaoka S. [Prophylactic strategies for perioperative pulmonary embolism]. Masui. 2003 May; 52(5):547-50.
    View in: PubMed
  33. Kishi Y, Mizobuchi A, Kuri M, Baba M, Taniguchi H, Nakagawa M, Mammoto T, Kanbara N, Sakai T. [Anesthetic management of two patients with hypertrophic obstructive cardiomyopathy for percutaneous transluminal septal myocardial ablation]. Masui. 2003 Jan; 52(1):42-5.
    View in: PubMed
  34. Mukai M, Togawa A, Imamura F, Iwasaki T, Ayaki M, Mammoto T, Nakamura H, Tatsuta M, Inoue M. Sustained tyrosine-phosphorylation of FAK through Rho-dependent adhesion to fibronectin is essential for cancer cell migration. Anticancer Res. 2002 Nov-Dec; 22(6A):3175-84.
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  35. Mammoto T, Mukai M, Mammoto A, Yamanaka Y, Hayashi Y, Mashimo T, Kishi Y, Nakamura H. Intravenous anesthetic, propofol inhibits invasion of cancer cells. Cancer Lett. 2002 Oct 28; 184(2):165-70.
    View in: PubMed
  36. Mammoto T, Higashiyama S, Mukai M, Mammoto A, Ayaki M, Mashimo T, Hayashi Y, Kishi Y, Nakamura H, Akedo H. Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF). J Cell Physiol. 2002 Sep; 192(3):351-8.
    View in: PubMed
  37. Kita T, Mammoto T, Kishi Y. Fluid management and postoperative respiratory disturbances in patients with transthoracic esophagectomy for carcinoma. J Clin Anesth. 2002 Jun; 14(4):252-6.
    View in: PubMed
  38. Kishi Y, Taniguchi H, Nakagawa M, Kita T, Mammoto T, Kanbara N, Sakai T. [Anesthesia for partial pulmonary resection in a postpneumonectomy patient]. Masui. 2002 Mar; 51(3):261-3.
    View in: PubMed
  39. Nakata K, Mammoto T, Kita T, Taniguchi H, Kanbara N, Akamatsu T, Sakai T, Kishi Y. Continuous epidural, not intravenous, droperidol inhibits pruritus, nausea, and vomiting during epidural morphine analgesia. J Clin Anesth. 2002 Mar; 14(2):121-5.
    View in: PubMed
  40. Yamanaka Y, Mammoto T, Kirita T, Mukai M, Mashimo T, Sugimura M, Kishi Y, Nakamura H. Epinephrine inhibits invasion of oral squamous carcinoma cells by modulating intracellular cAMP. Cancer Lett. 2002 Feb 25; 176(2):143-8.
    View in: PubMed
  41. Katayama S, Kita T, Mammoto T, Kawahara M, Kishi Y. [Perioperative management for radical esophagectomy in a patient with polycythemia vera]. Masui. 2001 Dec; 50(12):1345-7.
    View in: PubMed
  42. Kita T, Kagawa K, Mammoto T, Takada K, Hayashi Y, Mashimo T, Kishi Y. Diabetes attenuates the minimum anaesthetic concentration (MAC) and MAC-blocking adrenergic response reducing actions of clonidine in rats. Acta Anaesthesiol Scand. 2001 Nov; 45(10):1230-4.
    View in: PubMed
  43. Yamanaka Y, Mammoto T, Kita T, Kishi Y. A study of 13 patients with gastric tube in place after esophageal resection: use of omeprazole to decrease gastric acidity and volume. J Clin Anesth. 2001 Aug; 13(5):370-3.
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  44. Katayama S, Mammoto T, Kita T, Kawahara M, Kishi Y. [Transthoracic radical esophagectomy after extensive myocardial infarction]. Masui. 2001 Aug; 50(8):878-81.
    View in: PubMed
  45. Kita T, Mammoto T, Kishi Y. [Monitoring of cerebral oxygenation status with near-infrared spectroscopy during inferior vena caval reconstruction under extracorporeal circulation]. Masui. 2001 Aug; 50(8):890-4.
    View in: PubMed
  46. Kita T, Nakata K, Mammoto T, Kishi Y. Anesthetic management of a patient with hypertrophic obstructive cardiomyopathy after percutaneous transluminal septal myocardial ablation: early postinterventional period and anesthetic considerations. J Cardiothorac Vasc Anesth. 2001 Jun; 15(3):362-3.
    View in: PubMed
  47. Yamasaki K, Nakata K, Hazama A, Kita T, Mammoto T, Kanbara N, Sakai T, Kishi Y. [Usefulness of a simple expiratory gas monitor during sedation under spinal anesthesia]. Masui. 2001 Apr; 50(4):433-6.
    View in: PubMed
  48. Nakagawa M, Mammoto T, Sakai T, Kishi Y, Mashimo T. Premedication modifies the quality of sedation with propofol during regional anesthesia. Can J Anaesth. 2001 Mar; 48(3):284-7.
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  49. Matsumoto E, Yamasaki K, Nakata K, Hazama A, Kita T, Mammoto T, Kambara N, Sakai T, Kishi Y. [Effects of infusion methods of propofol on quality of sedation and ease of sedation control during gynecological laparotomy under spinal anesthesia]. Masui. 2000 Oct; 49(10):1103-8.
    View in: PubMed
  50. Ohnishi M, Hazama A, Kita T, Mammoto T, Akamatsu T, Kambara N, Sakai T, Kishi Y. [Anesthesia for MIDCAB (minimally invasive direct coronary bypass) in a patient with Tangier disease: a case report]. Masui. 2000 Apr; 49(4):407-9.
    View in: PubMed
  51. Kita T, Kagawa K, Mammoto T, Takada K, Hayashi Y, Mashimo T, Kishi Y. Supraspinal, not spinal, alpha(2) adrenoceptors are involved in the anesthetic-sparing and hemodynamic-stabilizing effects of systemic clonidine in rats. Anesth Analg. 2000 Mar; 90(3):722-6.
    View in: PubMed
  52. Ayaki M, Mukai M, Imamura F, Iwasaki T, Mammoto T, Shinkai K, Nakamura H, Akedo H. Cooperation of fibronectin with lysophosphatidic acid induces motility and transcellular migration of rat ascites hepatoma cells. Biochim Biophys Acta. 2000 Jan 10; 1495(1):40-50.
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  53. Nakagawa M, Mammoto T, Hazama A, Kita T, Akamatsu T, Kambara N, Sakai T, Kishi Y. Midazolam premedication reduces propofol requirements for sedation during regional anesthesia. Can J Anaesth. 2000 Jan; 47(1):47-9.
    View in: PubMed
  54. Murakami K, Mammoto T, Kita T, Imai Y, Mashimo T, Kirita T, Sugimura M, Kishi Y. Oral clonidine reduces the requirement of prostaglandin E1 for induced hypotension. Can J Anaesth. 1999 Nov; 46(11):1043-7.
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  55. Murata K, Kameyama M, Fukui F, Ohigashi H, Hiratsuka M, Sasaki Y, Kabuto T, Mukai M, Mammoto T, Akedo H, Ishikawa O, Imaoka S. Phosphodiesterase type III inhibitor, cilostazol, inhibits colon cancer cell motility. Clin Exp Metastasis. 1999; 17(6):525-30.
    View in: PubMed
  56. Imai Y, Mammoto T, Murakami K, Kita T, Sakai T, Kagawa K, Kirita T, Sugimura M, Kishi Y. The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia. J Clin Anesth. 1998 Dec; 10(8):660-5.
    View in: PubMed
  57. Mammoto T, Hayashi Y, Ohnishi Y, Kuro M. Incidence of venous and paradoxical air embolism in neurosurgical patients in the sitting position: detection by transesophageal echocardiography. Acta Anaesthesiol Scand. 1998 Jul; 42(6):643-7.
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  58. Kagawa K, Mammoto T, Hayashi Y, Kamibayashi T, Mashimo T, Yoshiya I. The effect of imidazoline receptors and alpha2-adrenoceptors on the anesthetic requirement (MAC) for halothane in rats. Anesthesiology. 1997 Oct; 87(4):963-7.
    View in: PubMed
  59. Mammoto T, Yamamoto Y, Kagawa K, Hayashi Y, Mashimo T, Yoshiya I, Yamatodani A. Interactions between neuronal histamine and halothane anesthesia in rats. J Neurochem. 1997 Jul; 69(1):406-11.
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  60. Takada K, Hayashi Y, Kamibayashi T, Mammoto T, Yamatodani A, Kitamura S, Yoshiya I. The involvement of pertussis toxin-sensitive G proteins in the post receptor mechanism of central I1-imidazoline receptors. Br J Pharmacol. 1997 Apr; 120(8):1575-81.
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  61. Mammoto T, Kamibayashi T, Hayashi Y, Yamatodani A, Takada K, Yoshiya I. Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br J Pharmacol. 1996 Apr; 117(8):1744-8.
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  62. Kamibayashi T, Hayashi Y, Mammoto T, Yamatodani A, Sumikawa K, Yoshiya I. Role of the vagus nerve in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology. 1995 Nov; 83(5):992-9.
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  63. Kamibayashi T, Mammoto T, Hayashi Y, Yamatodani A, Takada K, Sasaki S, Yoshiya I. Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology. 1995 Nov; 83(5):1082-9.
    View in: PubMed
  64. Kamibayashi T, Hayashi Y, Mammoto T, Yamatodani A, Taenaka N, Yoshiya I. Thoracic epidural anesthesia attenuates halothane-induced myocardial sensitization to dysrhythmogenic effect of epinephrine in dogs. Anesthesiology. 1995 Jan; 82(1):129-34.
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  65. Mammoto T, Kamibayashi T, Hayashi Y, Takada K, Yamatodani A, Yoshiya I. Rilmenidine prevents epinephrine-induced arrhythmias in halothane-anesthetized dogs. J Cardiovasc Pharmacol. 1995; 26 Suppl 2:S40-3.
    View in: PubMed
  66. Hayashi Y, Sumikawa K, Yamatodani A, Kamibayashi T, Mammoto T, Kuro M. Quantitative analysis of pulmonary clearance of exogenous dopamine after cardiopulmonary bypass in humans. Anesth Analg. 1993 Jan; 76(1):107-12.
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  67. Hayashi Y, Sumikawa K, Kamibayashi T, Yamatodani A, Mammoto T, Kuro M, Yoshiya I. Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs. Can J Anaesth. 1992 Oct; 39(8):873-6.
    View in: PubMed
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