Christos Mantzoros, M.D.
|Title||Professor of Medicine|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Beth Israel Deaconess Med Ctr|
330 Brookline Ave
Boston MA 02215
Available: 08/01/12, Expires: 07/31/14
Adipose tissue plays an active role in energy homeostasis because it not only stores/mobilizes lipids but also produces heat or releases a vast number of hormones so called adipokines. Similarly, muscle secretes myokines that interact with adipose tissue and adipose tissue secreted molecules to alter energy homeostasis, body weight and risk for diabetes and cardiovascular disease. The research project in our laboratory will focus on the molecular mechanisms and signaling pathways mediating the effects of novel myokines in metabolic diseases, such as obesity and diabetes. This project will involve in vitro experiments using both mouse and human samples and analysis of human clinical samples from clinical trials on obesity and diabtes. Students will be guided by a postdoctoral fellow and acquire the basic research techniques needed to excel in the molecular biology area. Preferably, candidates should have strong interest in translational research and be eager to learn new things. Exploring the mechanism of action of novel hormones on metabolism will be an enjoyable and valuable experience as the student will learn how to translate basic research findings into clinical discoveries applicable to human diseases and their treatments.
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