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Last Name
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Vijay Kumar Kuchroo, PH.D.

TitleSamuel L. Wasserstrom Professor of Neurology
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressBrigham and Women's Hospital
Ctr for Neurological Diseases
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-5350
Fax617/525-5333

 Mentoring 
 completed student projects
Th1-specific T Cell Immunoglobulin and Mucin-domain-containing molecule (Tim) family genes in autoimmunity
Summer, 06/01/02 - 08/31/02
Phenotypic Characterization of Putative Helper T Cell Subset Induced by Innate Cytokine Milieu
Summer, 06/14/10 - 08/06/10
Induction of T regulatory type 1-like phenotype in CD4+ T cells by interleukin-27 and interferon-á
Summer, 06/21/10 - 08/14/10

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
BWH-BRI Antibody Core Facility - Antibodies (18) and Core services (1)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Joller N, Kuchroo VK. Good guys gone bad: exTreg cells promote autoimmune arthritis. Nat Med. 2014 Jan 7; 20(1):15-7.
    View in: PubMed
  2. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Corrigendum: Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2013 Dec 18; 15(1):109.
    View in: PubMed
  3. Pot C, Quintana FJ, Kuchroo VK. Fine tuning of the immune response by the Aryl Hydrocarbon Receptor. Semin Immunopathol. 2013 Nov; 35(6):613.
    View in: PubMed
  4. Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013 Oct; 14(10):1054-63.
    View in: PubMed
  5. Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest. 2013 Sep 3; 123(9):4023-35.
    View in: PubMed
  6. Sjöstrand M, Ambrosi A, Brauner S, Sullivan J, Malin S, Kuchroo VK, Espinosa A, Wahren-Herlenius M. Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors. J Immunol. 2013 Oct 1; 191(7):3753-63.
    View in: PubMed
  7. Rangachari M, Kuchroo VK. Using EAE to better understand principles of immune function and autoimmune pathology. J Autoimmun. 2013 Sep; 45:31-9.
    View in: PubMed
  8. Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, Chen SH, He JC, Ting AT, Zhou MM, Kuchroo VK, Morse HC, Ozato K, Sikora AG, Xiong H. T cell–derived inducible nitric oxide synthase switches off T(H)17 cell differentiation. J Exp Med. 2013 Jul 1; 210(7):1447-62.
    View in: PubMed
  9. Baeten DL, Kuchroo VK. How Cytokine Networks Fuel Inflammation: Interleukin-17 and a tale of two autoimmune diseases. Nat Med. 2013 Jul; 19(7):824-5.
    View in: PubMed
  10. Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A. 2013 May 7; 110(19):7802-7.
    View in: PubMed
  11. Mitsdoerffer M, Kuchroo V, Korn T. Immunology of neuromyelitis optica: a T cell-B cell collaboration. Ann N Y Acad Sci. 2013 Apr; 1283(1):57-66.
    View in: PubMed
  12. Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 2013 Apr; 14(4):307-8.
    View in: PubMed
  13. Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson AC, Kuchroo VK, Remold HG, Behar SM. IL-1ß Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation. J Immunol. 2013 Apr 15; 190(8):4196-204.
    View in: PubMed
  14. Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ. IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet. J Immunol. 2013 Apr 15; 190(8):3977-84.
    View in: PubMed
  15. Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A. Dynamic regulatory network controlling TH17 cell differentiation. Nature. 2013 Apr 25; 496(7446):461-8.
    View in: PubMed
  16. Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature. 2013 Apr 25; 496(7446):513-7.
    View in: PubMed
  17. Ichinose K, Zhang Z, Koga T, Juang YT, Kis-Tóth K, Sharpe AH, Kuchroo V, Crispín JC, Tsokos GC. Brief Report: Increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum. 2013 Mar; 65(3):764-9.
    View in: PubMed
  18. Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH. MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2270-5.
    View in: PubMed
  19. Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB. TIM Family Proteins Promote the Lysosomal Degradation of the Nuclear Receptor NUR77. Sci Signal. 2012; 5(254):ra90.
    View in: PubMed
  20. Wang C, Wu L, Bulek K, Martin BN, Zepp JA, Kang Z, Liu C, Herjan T, Misra S, Carman JA, Gao J, Dongre A, Han S, Bunting KD, Ko JS, Xiao H, Kuchroo VK, Ouyang W, Li X. The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nat Immunol. 2013 Jan; 14(1):72-81.
    View in: PubMed
  21. Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012 Oct; 13(10):991-9.
    View in: PubMed
  22. Kuchroo VK, Awasthi A. Emerging new roles of Th17 cells. Eur J Immunol. 2012 Sep; 42(9):2211-4.
    View in: PubMed
  23. Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med. 2012 Sep; 18(9):1394-400.
    View in: PubMed
  24. Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24; 37(2):276-89.
    View in: PubMed
  25. Vignali DA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol. 2012 Aug; 13(8):722-8.
    View in: PubMed
  26. Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med. 2012 Jul 8.
    View in: PubMed
  27. Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12105-10.
    View in: PubMed
  28. Joller N, Peters A, Anderson AC, Kuchroo VK. Immune checkpoints in central nervous system autoimmunity. Immunol Rev. 2012 Jul; 248(1):122-39.
    View in: PubMed
  29. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2012 Aug; 13(8):770-7.
    View in: PubMed
  30. Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest. 2012 Jul 2; 122(7):2395-404.
    View in: PubMed
  31. Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR. Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 2012 Jul 19; 120(3):682-90.
    View in: PubMed
  32. Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. The TIGIT/CD226 axis regulates human T cell function. J Immunol. 2012 Apr 15; 188(8):3869-75.
    View in: PubMed
  33. Fowler KD, Kuchroo VK, Chakraborty AK. A model for how signal duration can determine distinct outcomes of gene transcription programs. PLoS One. 2012; 7(3):e33018.
    View in: PubMed
  34. Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012 Apr 1; 188(7):3127-37.
    View in: PubMed
  35. Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez-Manzanet R, Greve B, Sobel RA, Kuchroo VK. A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells. J Immunol. 2012 Mar 1; 188(5):2084-92.
    View in: PubMed
  36. Kuchroo VK, Ohashi PS, Sartor RB, Vinuesa CG. Dysregulation of immune homeostasis in autoimmune diseases. Nat Med. 2012 Jan; 18(1):42-7.
    View in: PubMed
  37. Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Olive D, Kuchroo V, Zarour HM. CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 2012 Feb 15; 72(4):887-96.
    View in: PubMed
  38. Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity. 2011 Dec 23; 35(6):986-96.
    View in: PubMed
  39. Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol. 2012 Jan 1; 188(1):155-62.
    View in: PubMed
  40. Ambrosi A, Dzikaite V, Park J, Strandberg L, Kuchroo VK, Herlenius E, Wahren-Herlenius M. Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model. Ann Rheum Dis. 2012 Mar; 71(3):448-54.
    View in: PubMed
  41. Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BT. T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):19001-6.
    View in: PubMed
  42. Liu SM, Lee DH, Sullivan JM, Chung D, Jäger A, Shum BO, Sarvetnick NE, Anderson AC, Kuchroo VK. Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. J Clin Invest. 2011 Nov; 121(11):4303-10.
    View in: PubMed
  43. Peters A, Lee Y, Kuchroo VK. The many faces of Th17 cells. Curr Opin Immunol. 2011 Dec; 23(6):702-6.
    View in: PubMed
  44. Pot C, Apetoh L, Awasthi A, Kuchroo VK. Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27. Semin Immunol. 2011 Dec; 23(6):438-45.
    View in: PubMed
  45. Awasthi A, Kuchroo VK. Value added: neural progenitor cells suppress inflammation and autoimmunity. Immunity. 2011 Aug 26; 35(2):156-7.
    View in: PubMed
  46. Pot C, Apetoh L, Kuchroo VK. Type 1 regulatory T cells (Tr1) in autoimmunity. Semin Immunol. 2011 Jun; 23(3):202-8.
    View in: PubMed
  47. Lee J, Su EW, Zhu C, Hainline S, Phuah J, Moroco JA, Smithgall TE, Kuchroo VK, Kane LP. Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways. Mol Cell Biol. 2011 Oct; 31(19):3963-74.
    View in: PubMed
  48. Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Control of TH17 cells occurs in the small intestine. Nature. 2011 Jul 28; 475(7357):514-8.
    View in: PubMed
  49. Thakker P, Marusic S, Stedman NL, Lee KL, McKew JC, Wood A, Goldman SJ, Leach MW, Collins M, Kuchroo VK, Wolf SF, Clark JD, Hassan-Zahraee M. Cytosolic phospholipase A2a blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs. J Immunol. 2011 Aug 15; 187(4):1986-97.
    View in: PubMed
  50. Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 2011 Aug; 32(8):345-9.
    View in: PubMed
  51. Xiao S, Zhu B, Jin H, Zhu C, Umetsu DT, DeKruyff RH, Kuchroo VK. Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells. Eur J Immunol. 2011 Jun; 41(6):1539-49.
    View in: PubMed
  52. Wahren-Herlenius M, Kuchroo VK. Gene-environment interaction in induction of autoimmunity. Semin Immunol. 2011 Apr; 23(2):65-6.
    View in: PubMed
  53. Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 2011 Apr 28; 117(17):4501-10.
    View in: PubMed
  54. Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol. 2011 Feb 1; 186(3):1338-42.
    View in: PubMed
  55. Zhu C, Anderson AC, Kuchroo VK. TIM-3 and its regulatory role in immune responses. Curr Top Microbiol Immunol. 2011; 350:1-15.
    View in: PubMed
  56. Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding ROR?t. Nat Immunol. 2011 Jan; 12(1):96-104.
    View in: PubMed
  57. Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM. Tim3 binding to galectin-9 stimulates antimicrobial immunity. J Exp Med. 2010 Oct 25; 207(11):2343-54.
    View in: PubMed
  58. Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR, Heink S, Prinz I, Hemmer B, Kuchroo VK, Oukka M, Korn T. ?d T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity. 2010 Sep 24; 33(3):351-63.
    View in: PubMed
  59. Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med. 2010 Sep 27; 207(10):2187-94.
    View in: PubMed
  60. Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Kuchroo V, Zarour HM. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med. 2010 Sep 27; 207(10):2175-86.
    View in: PubMed
  61. Jäger A, Kuchroo VK. Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol. 2010 Sep; 72(3):173-84.
    View in: PubMed
  62. Strandberg LS, Ambrosi A, Jagodic M, Dzikaite V, Janson P, Khademi M, Salomonsson S, Ottosson L, Klauninger R, Adén U, Sonesson SE, Sunnerhagen M, de Graaf KL, Kuchroo VK, Achour A, Winqvist O, Olsson T, Wahren-Herlenius M. Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block. J Immunol. 2010 Sep 15; 185(6):3574-82.
    View in: PubMed
  63. Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14733-8.
    View in: PubMed
  64. Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010 Sep; 11(9):854-61.
    View in: PubMed
  65. Mitsdoerffer M, Lee Y, Jäger A, Kim HJ, Korn T, Kolls JK, Cantor H, Bettelli E, Kuchroo VK. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14292-7.
    View in: PubMed
  66. Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol. 2010 Aug 1; 185(3):1383-92.
    View in: PubMed
  67. Pot C, Apetoh L, Awasthi A, Kuchroo VK. Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells. J Interferon Cytokine Res. 2010 Jun; 30(6):381-8.
    View in: PubMed
  68. Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 1; 185(1):46-54.
    View in: PubMed
  69. Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8706-11.
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  70. Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol. 2010 May 1; 184(9):4605-9.
    View in: PubMed
  71. Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK. T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur J Immunol. 2010 Mar; 40(3):859-66.
    View in: PubMed
  72. Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson BS, Croxford A, Waisman A, Kuchroo VK, Glimcher LH, Oukka M. IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol. 2010 Feb 15; 184(4):1710-20.
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  73. Korn T, Mitsdoerffer M, Kuchroo VK. Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis. Results Probl Cell Differ. 2010; 51:43-74.
    View in: PubMed
  74. Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009 Dec 21; 206(13):3015-29.
    View in: PubMed
  75. Jäger A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol. 2009 Dec 1; 183(11):7169-77.
    View in: PubMed
  76. Bluestone JA, Kuchroo V. Autoimmunity. Curr Opin Immunol. 2009 Dec; 21(6):579-81.
    View in: PubMed
  77. Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS. Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. J Immunol. 2009 Oct 15; 183(8):5146-57.
    View in: PubMed
  78. Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep; 39(9):2492-501.
    View in: PubMed
  79. Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med. 2009 Aug 27; 361(9):888-98.
    View in: PubMed
  80. Awasthi A, Kuchroo VK. Immunology. The yin and yang of follicular helper T cells. Science. 2009 Aug 21; 325(5943):953-5.
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  81. Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Quintana FJ, Sjöstrand M, Eloranta ML, Ní Gabhann J, Winqvist O, Sundelin B, Jefferies CA, Rozell B, Kuchroo VK, Wahren-Herlenius M. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med. 2009 Aug 3; 206(8):1661-71.
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  82. Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol. 2009 Sep; 83(18):9122-30.
    View in: PubMed
  83. Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009 Jul 15; 183(2):797-801.
    View in: PubMed
  84. Awasthi A, Kuchroo VK. IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation. Nat Immunol. 2009 Jun; 10(6):568-70.
    View in: PubMed
  85. Awasthi A, Riol-Blanco L, Jäger A, Korn T, Pot C, Galileos G, Bettelli E, Kuchroo VK, Oukka M. Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. J Immunol. 2009 May 15; 182(10):5904-8.
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  86. Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ. IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 2009 Aug 4; 106(31):12885-90.
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  87. Mitsdoerffer M, Kuchroo V. New pieces in the puzzle: how does interferon-beta really work in multiple sclerosis? Ann Neurol. 2009 May; 65(5):487-8.
    View in: PubMed
  88. Rodriguez-Manzanet R, DeKruyff R, Kuchroo VK, Umetsu DT. The costimulatory role of TIM molecules. Immunol Rev. 2009 May; 229(1):259-70.
    View in: PubMed
  89. Kaufmann SH, Kuchroo VK. Th17 cells. Microbes Infect. 2009 Apr; 11(5):579-83.
    View in: PubMed
  90. Awasthi A, Kuchroo VK. Th17 cells: from precursors to players in inflammation and infection. Int Immunol. 2009 May; 21(5):489-98.
    View in: PubMed
  91. Oke V, Vassilaki I, Espinosa A, Strandberg L, Kuchroo VK, Nyberg F, Wahren-Herlenius M. High Ro52 expression in spontaneous and UV-induced cutaneous inflammation. J Invest Dermatol. 2009 Aug; 129(8):2000-10.
    View in: PubMed
  92. Mariat C, Degauque N, Balasubramanian S, Kenny J, DeKruyff RH, Umetsu DT, Kuchroo V, Zheng XX, Strom TB. Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. J Immunol. 2009 Feb 1; 182(3):1379-85.
    View in: PubMed
  93. Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009 Apr 30; 113(18):4240-9.
    View in: PubMed
  94. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol. 2009; 27:485-517.
    View in: PubMed
  95. Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol. 2009 Feb; 10(2):167-75.
    View in: PubMed
  96. Anderson AC, Chandwaskar R, Lee DH, Kuchroo VK. Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC. J Immunol. 2008 Dec 1; 181(11):7449-52.
    View in: PubMed
  97. Nagahara K, Arikawa T, Oomizu S, Kontani K, Nobumoto A, Tateno H, Watanabe K, Niki T, Katoh S, Miyake M, Nagahata S, Hirabayashi J, Kuchroo VK, Yamauchi A, Hirashima M. Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions. J Immunol. 2008 Dec 1; 181(11):7660-9.
    View in: PubMed
  98. Hafler DA, Kuchroo V. TIMs: central regulators of immune responses. J Exp Med. 2008 Nov 24; 205(12):2699-701.
    View in: PubMed
  99. Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, Galileos G, Vollmar P, Stritesky GL, Kaplan MH, Waisman A, Kuchroo VK, Oukka M. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18460-5.
    View in: PubMed
  100. Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol. 2008 Dec; 9(12):1347-55.
    View in: PubMed
  101. Hafler JP, Maier LM, Cooper JD, Plagnol V, Hinks A, Simmonds MJ, Stevens HE, Walker NM, Healy B, Howson JM, Maisuria M, Duley S, Coleman G, Gough SC, Worthington J, Kuchroo VK, Wicker LS, Todd JA. CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun. 2009 Jan; 10(1):5-10.
    View in: PubMed
  102. Awasthi A, Murugaiyan G, Kuchroo VK. Interplay between effector Th17 and regulatory T cells. J Clin Immunol. 2008 Nov; 28(6):660-70.
    View in: PubMed
  103. Xiao S, Jin H, Korn T, Liu SM, Oukka M, Lim B, Kuchroo VK. Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol. 2008 Aug 15; 181(4):2277-84.
    View in: PubMed
  104. Kuchroo VK, Dardalhon V, Xiao S, Anderson AC. New roles for TIM family members in immune regulation. Nat Rev Immunol. 2008 Aug; 8(8):577-80.
    View in: PubMed
  105. Laouar Y, Town T, Jeng D, Tran E, Wan Y, Kuchroo VK, Flavell RA. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31):10865-70.
    View in: PubMed
  106. Elyaman W, Kivisäkk P, Reddy J, Chitnis T, Raddassi K, Imitola J, Bradshaw E, Kuchroo VK, Yagita H, Sayegh MH, Khoury SJ. Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis. Am J Pathol. 2008 Aug; 173(2):411-22.
    View in: PubMed
  107. Bettelli E, Korn T, Oukka M, Kuchroo VK. Induction and effector functions of T(H)17 cells. Nature. 2008 Jun 19; 453(7198):1051-7.
    View in: PubMed
  108. Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol. 2008 Jun 1; 180(11):7327-37.
    View in: PubMed
  109. Dardalhon V, Korn T, Kuchroo VK, Anderson AC. Role of Th1 and Th17 cells in organ-specific autoimmunity. J Autoimmun. 2008 Nov; 31(3):252-6.
    View in: PubMed
  110. Tzianabos AO, Holsti MA, Zheng XX, Stucchi AF, Kuchroo VK, Strom TB, Glimcher LH, Cruikshank WW. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol. 2008 May 15; 180(10):6970-6.
    View in: PubMed
  111. Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008 Jul 17; 454(7202):350-2.
    View in: PubMed
  112. Strandberg L, Ambrosi A, Espinosa A, Ottosson L, Eloranta ML, Zhou W, Elfving A, Greenfield E, Kuchroo VK, Wahren-Herlenius M. Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies. J Clin Immunol. 2008 May; 28(3):220-31.
    View in: PubMed
  113. Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol. 2008 Apr 1; 180(7):4706-13.
    View in: PubMed
  114. Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M. Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol. 2008 Apr; 127(1):78-88.
    View in: PubMed
  115. Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB. Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest. 2008 Feb; 118(2):735-41.
    View in: PubMed
  116. Seki M, Sakata KM, Oomizu S, Arikawa T, Sakata A, Ueno M, Nobumoto A, Niki T, Saita N, Ito K, Dai SY, Katoh S, Nishi N, Tsukano M, Ishikawa K, Yamauchi A, Kuchroo V, Hirashima M. Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts. Arthritis Rheum. 2007 Dec; 56(12):3968-76.
    View in: PubMed
  117. Korn T, Oukka M, Kuchroo V, Bettelli E. Th17 cells: effector T cells with inflammatory properties. Semin Immunol. 2007 Dec; 19(6):362-71.
    View in: PubMed
  118. Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science. 2007 Nov 16; 318(5853):1141-3.
    View in: PubMed
  119. Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007 Dec; 8(12):1380-9.
    View in: PubMed
  120. Zhu B, Bando Y, Xiao S, Yang K, Anderson AC, Kuchroo VK, Khoury SJ. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol. 2007 Oct 15; 179(8):5228-37.
    View in: PubMed
  121. Illés Z, Waldner H, Reddy J, Anderson AC, Sobel RA, Kuchroo VK. Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background. Int Immunol. 2007 Oct; 19(10):1235-48.
    View in: PubMed
  122. Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell trilogy. Curr Opin Immunol. 2007 Dec; 19(6):652-7.
    View in: PubMed
  123. Degauque N, Mariat C, Kenny J, Sanchez-Fueyo A, Alexopoulos SP, Kuchroo V, Zheng XX, Strom TB. Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins. Transplantation. 2007 Jul 15; 84(1 Suppl):S12-6.
    View in: PubMed
  124. Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med. 2007 Jul 9; 204(7):1691-702.
    View in: PubMed
  125. Greve B, Weissert R, Hamdi N, Bettelli E, Sobel RA, Coyle A, Kuchroo VK, Rajewsky K, Schmidt-Supprian M. I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. J Immunol. 2007 Jul 1; 179(1):179-85.
    View in: PubMed
  126. Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007 Jul 26; 448(7152):484-7.
    View in: PubMed
  127. Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant. 2007 Jul; 7(7):1722-32.
    View in: PubMed
  128. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11; 204(6):1257-65.
    View in: PubMed
  129. Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007 Apr; 8(4):345-50.
    View in: PubMed
  130. Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med. 2007 Apr; 13(4):423-31.
    View in: PubMed
  131. Anderson AC, Xiao S, Kuchroo VK. Tim protein structures reveal a unique face for ligand binding. Immunity. 2007 Mar; 26(3):273-5.
    View in: PubMed
  132. O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007 Feb; 13(2):211-7.
    View in: PubMed
  133. Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice. J Immunol. 2007 Jan 1; 178(1):179-85.
    View in: PubMed
  134. Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity. J Immunol. 2007 Jan 1; 178(1):172-8.
    View in: PubMed
  135. Bettelli E, Baeten D, Jäger A, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest. 2006 Sep; 116(9):2393-402.
    View in: PubMed
  136. Haynes L, Pfeffer S, Boss JM, Kavathas P, Kuchroo V. Lab management: insights for the new investigator. Nat Immunol. 2006 Sep; 7(9):895-7.
    View in: PubMed
  137. Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006 Jun 12; 203(6):1413-8.
    View in: PubMed
  138. Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Oukka M, Nyberg F, Kuchroo VK, Wahren-Herlenius M. The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death. J Immunol. 2006 May 15; 176(10):6277-85.
    View in: PubMed
  139. Waldner H, Sobel RA, Price N, Kuchroo VK. The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol. 2006 May 1; 176(9):5455-62.
    View in: PubMed
  140. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11; 441(7090):235-8.
    View in: PubMed
  141. Zhang X, Reddy J, Ochi H, Frenkel D, Kuchroo VK, Weiner HL. Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells. Int Immunol. 2006 Apr; 18(4):495-503.
    View in: PubMed
  142. Greenfield EA, Reddy J, Lees A, Dyer CA, Koul O, Nguyen K, Bell S, Kassam N, Hinojoza J, Eaton MJ, Lees MB, Kuchroo VK, Sobel RA. Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species. J Neurosci Res. 2006 Feb 15; 83(3):415-31.
    View in: PubMed
  143. Kuchroo VK, Meyers JH, Umetsu DT, DeKruyff RH. TIM family of genes in immunity and tolerance. Adv Immunol. 2006; 91:227-49.
    View in: PubMed
  144. Illes Z, Stern JN, Keskin DB, Reddy J, Brosnan CF, Waldner H, Santambrogio L, Kuchroo VK, Strominger JL. Copolymer effects on microglia and T cells in the central nervous system of humanized mice. Eur J Immunol. 2005 Dec; 35(12):3683-93.
    View in: PubMed
  145. Miyamoto K, Kingsley CI, Zhang X, Jabs C, Izikson L, Sobel RA, Weiner HL, Kuchroo VK, Sharpe AH. The ICOS molecule plays a crucial role in the development of mucosal tolerance. J Immunol. 2005 Dec 1; 175(11):7341-7.
    View in: PubMed
  146. Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol. 2005 Dec; 6(12):1245-52.
    View in: PubMed
  147. Reddy J, Waldner H, Zhang X, Illes Z, Wucherpfennig KW, Sobel RA, Kuchroo VK. Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 1; 175(9):5591-5.
    View in: PubMed
  148. Illés Z, Waldner H, Reddy J, Bettelli E, Nicholson LB, Kuchroo VK. T cell tolerance induced by cross-reactive TCR ligands can be broken by superagonist resulting in anti-inflammatory T cell cytokine production. J Immunol. 2005 Aug 1; 175(3):1491-7.
    View in: PubMed
  149. Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK. CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J Immunol. 2005 Aug 1; 175(3):1558-65.
    View in: PubMed
  150. Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med. 2005 Aug; 11(8):362-9.
    View in: PubMed
  151. Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK. Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med. 2005 Aug 1; 202(3):437-44.
    View in: PubMed
  152. Hennig J, Ottosson L, Andrésen C, Horvath L, Kuchroo VK, Broo K, Wahren-Herlenius M, Sunnerhagen M. Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52. J Biol Chem. 2005 Sep 30; 280(39):33250-61.
    View in: PubMed
  153. Yu P, Gregg RK, Bell JJ, Ellis JS, Divekar R, Lee HH, Jain R, Waldner H, Hardaway JC, Collins M, Kuchroo VK, Zaghouani H. Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen. J Immunol. 2005 Jun 1; 174(11):6772-80.
    View in: PubMed
  154. Meyers JH, Chakravarti S, Schlesinger D, Illes Z, Waldner H, Umetsu SE, Kenny J, Zheng XX, Umetsu DT, DeKruyff RH, Strom TB, Kuchroo VK. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol. 2005 May; 6(5):455-64.
    View in: PubMed
  155. Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK, Altmann DM. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J Immunol. 2005 Feb 15; 174(4):1938-46.
    View in: PubMed
  156. Ottosson L, Salomonsson S, Hennig J, Sonesson SE, Dörner T, Raats J, Kuchroo VK, Sunnerhagen M, Wahren-Herlenius M. Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein. Scand J Immunol. 2005 Feb; 61(2):109-18.
    View in: PubMed
  157. Stern JN, Illés Z, Reddy J, Keskin DB, Fridkis-Hareli M, Kuchroo VK, Strominger JL. Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1620-5.
    View in: PubMed
  158. Bettelli E, Kuchroo VK. IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J Exp Med. 2005 Jan 17; 201(2):169-71.
    View in: PubMed
  159. Salomonsson S, Sonesson SE, Ottosson L, Muhallab S, Olsson T, Sunnerhagen M, Kuchroo VK, Thorén P, Herlenius E, Wahren-Herlenius M. Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block. J Exp Med. 2005 Jan 3; 201(1):11-7.
    View in: PubMed
  160. Vijayakrishnan L, Slavik JM, Illés Z, Rainbow D, Peterson LB, Sharpe AS, Wicker LS, Kuchroo VK. An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells. Novartis Found Symp. 2005; 267:200-12; discussion 212-8.
    View in: PubMed
  161. Reddy J, Illes Z, Zhang X, Encinas J, Pyrdol J, Nicholson L, Sobel RA, Wucherpfennig KW, Kuchroo VK. Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2004 Oct 26; 101(43):15434-9.
    View in: PubMed
  162. Tadokoro CE, Vallochi AL, Rios LS, Martins GA, Schlesinger D, Mosca T, Kuchroo VK, Rizzo LV, Abrahamsohn IA. Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi. J Autoimmun. 2004 Sep; 23(2):103-15.
    View in: PubMed
  163. Illés Z, Stern JN, Reddy J, Waldner H, Mycko MP, Brosnan CF, Ellmerich S, Altmann DM, Santambrogio L, Strominger JL, Kuchroo VK. Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11749-54.
    View in: PubMed
  164. Stern JN, Illés Z, Reddy J, Keskin DB, Sheu E, Fridkis-Hareli M, Nishimura H, Brosnan CF, Santambrogio L, Kuchroo VK, Strominger JL. Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11743-8.
    View in: PubMed
  165. Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol. 2004 Aug 1; 173(3):1689-98.
    View in: PubMed
  166. Anderson AC, Reddy J, Nazareno R, Sobel RA, Nicholson LB, Kuchroo VK. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol. 2004 Jul 15; 173(2):828-34.
    View in: PubMed
  167. Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10691-6.
    View in: PubMed
  168. Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med. 2004 Jul 5; 200(1):79-87.
    View in: PubMed
  169. Greve B, Reddy J, Waldner HP, Sobel RA, Kuchroo VK. Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes. Eur J Immunol. 2004 Jul; 34(7):1828-38.
    View in: PubMed
  170. Greve B, Vijayakrishnan L, Kubal A, Sobel RA, Peterson LB, Wicker LS, Kuchroo VK. The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J Immunol. 2004 Jul 1; 173(1):157-63.
    View in: PubMed
  171. Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. Eur J Immunol. 2004 Jul; 34(7):1839-48.
    View in: PubMed
  172. Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol. 2004 Jun 1; 172(11):7169-76.
    View in: PubMed
  173. Hawiger D, Masilamani RF, Bettelli E, Kuchroo VK, Nussenzweig MC. Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity. 2004 Jun; 20(6):695-705.
    View in: PubMed
  174. Petersen TR, Gülland S, Bettelli E, Kuchroo V, Palmer E, Bäckström BT. A chimeric T cell receptor with super-signaling properties. Int Immunol. 2004 Jul; 16(7):889-94.
    View in: PubMed
  175. Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 2004 May; 20(5):563-75.
    View in: PubMed
  176. Waldner H, Collins M, Kuchroo VK. Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest. 2004 Apr; 113(7):990-7.
    View in: PubMed
  177. Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol. 2004 Feb; 16(2):249-56.
    View in: PubMed
  178. Petersen TR, Bettelli E, Sidney J, Sette A, Kuchroo V, Bäckström BT. Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide. Eur J Immunol. 2004 Jan; 34(1):165-73.
    View in: PubMed
  179. Anderson AC, Kuchroo VK. Expression of self-antigen in the thymus: a little goes a long way. J Exp Med. 2003 Dec 1; 198(11):1627-9.
    View in: PubMed
  180. Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutiérrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003 Nov; 4(11):1093-101.
    View in: PubMed
  181. Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003 Nov; 4(11):1102-10.
    View in: PubMed
  182. Robinson WH, Fontoura P, Lee BJ, de Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003 Sep; 21(9):1033-9.
    View in: PubMed
  183. Chang TT, Sobel RA, Wei T, Ransohoff RM, Kuchroo VK, Sharpe AH. Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. Eur J Immunol. 2003 Jul; 33(7):2022-2032.
    View in: PubMed
  184. Kuchroo VK, Umetsu DT, DeKruyff RH, Freeman GJ. The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol. 2003 Jun; 3(6):454-62.
    View in: PubMed
  185. Bettelli E, Nicholson LB, Kuchroo VK. IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis. J Autoimmun. 2003 Jun; 20(4):265-7.
    View in: PubMed
  186. Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 5; 197(9):1073-81.
    View in: PubMed
  187. Kuchroo VK, Nicholson LB. Immunology: Fast and feel good? Nature. 2003 Mar 6; 422(6927):27-8.
    View in: PubMed
  188. Reddy J, Bettelli E, Nicholson L, Waldner H, Jang MH, Wucherpfennig KW, Kuchroo VK. Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J Immunol. 2003 Jan 15; 170(2):870-7.
    View in: PubMed
  189. Wahren-Herlenius M, Kuchroo VK. Killers come to the rescue. Nat Biotechnol. 2002 Dec; 20(12):1205-6.
    View in: PubMed
  190. Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK. Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions. J Immunol. 2002 Nov 15; 169(10):5382-6.
    View in: PubMed
  191. Munder M, Bettelli E, Monney L, Slavik JM, Nicholson LB, Kuchroo VK. Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand. J Exp Med. 2002 Nov 4; 196(9):1151-62.
    View in: PubMed
  192. Howie D, Okamoto S, Rietdijk S, Clarke K, Wang N, Gullo C, Bruggeman JP, Manning S, Coyle AJ, Greenfield E, Kuchroo V, Terhorst C. The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood. 2002 Oct 15; 100(8):2899-907.
    View in: PubMed
  193. Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol. 2002 Sep; 32(9):2687-97.
    View in: PubMed
  194. Freeman GJ, Sharpe AH, Kuchroo VK. Protect the killer: CTLs need defenses against the tumor. Nat Med. 2002 Aug; 8(8):787-9.
    View in: PubMed
  195. Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK. Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. J Immunol. 2002 May 15; 168(10):5070-8.
    View in: PubMed
  196. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002 Jan 31; 415(6871):536-41.
    View in: PubMed
  197. Chang TT, Kuchroo VK, Sharpe AH. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Curr Dir Autoimmun. 2002; 5:113-30.
    View in: PubMed
  198. McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec; 2(12):1109-16.
    View in: PubMed
  199. Gaglia JL, Mattoo A, Greenfield EA, Freeman GJ, Kuchroo VK. Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation. Cell Immunol. 2001 Nov 1; 213(2):83-93.
    View in: PubMed
  200. Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, Nicholson LB. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu Rev Immunol. 2002; 20:101-23.
    View in: PubMed
  201. Stremmel C, Exley M, Balk S, Hohenberger W, Kuchroo VK. Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets. Eur J Immunol. 2001 Sep; 31(9):2818-28.
    View in: PubMed
  202. Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A, Kuchroo V, Cohen IR, Weiner H, Schwartz M. Protective autoimmunity is a physiological response to CNS trauma. J Neurosci. 2001 Jun 1; 21(11):3740-8.
    View in: PubMed
  203. Theien BE, Vanderlugt CL, Eagar TN, Nickerson-Nutter C, Nazareno R, Kuchroo VK, Miller SD. Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. J Clin Invest. 2001 Apr; 107(8):995-1006.
    View in: PubMed
  204. Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Int Immunol. 2001 Mar; 13(3):257-64.
    View in: PubMed
  205. Anderson AC, Nicholson LB, Kuchroo VK. The origin and regulation of autopathogenic T cells. J Clin Immunol. 2001 Mar; 21(2):74-80.
    View in: PubMed
  206. Encinas JA, Kuchroo VK. Mapping and identification of autoimmunity genes. Curr Opin Immunol. 2000 Dec; 12(6):691-7.
    View in: PubMed
  207. Gaglia JL, Greenfield EA, Mattoo A, Sharpe AH, Freeman GJ, Kuchroo VK. Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells. J Immunol. 2000 Dec 1; 165(11):6091-8.
    View in: PubMed
  208. McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe AH, Freeman GJ. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol. 2000 Nov 1; 165(9):5035-40.
    View in: PubMed
  209. Nicholson LB, Kuchroo VK. Selecting killers: the line between life and death. Nat Immunol. 2000 Sep; 1(3):192-4.
    View in: PubMed
  210. Anderson AC, Waldner H, Turchin V, Jabs C, Prabhu Das M, Kuchroo VK, Nicholson LB. Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity. Cell Immunol. 2000 Jun 15; 202(2):88-96.
    View in: PubMed
  211. Young DA, Lowe LD, Booth SS, Whitters MJ, Nicholson L, Kuchroo VK, Collins M. IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. J Immunol. 2000 Apr 1; 164(7):3563-72.
    View in: PubMed
  212. Waldner H, Whitters MJ, Sobel RA, Collins M, Kuchroo VK. Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3412-7.
    View in: PubMed
  213. Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, Kuchroo VK. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J Exp Med. 2000 Mar 6; 191(5):761-70.
    View in: PubMed
  214. Nicholson LB, Anderson AC, Kuchroo VK. Tuning T cell activation threshold and effector function with cross-reactive peptide ligands. Int Immunol. 2000 Feb; 12(2):205-13.
    View in: PubMed
  215. Griffiths MM, Encinas JA, Remmers EF, Kuchroo VK, Wilder RL. Mapping autoimmunity genes. Curr Opin Immunol. 1999 Dec; 11(6):689-700.
    View in: PubMed
  216. Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J Exp Med. 1999 Sep 6; 190(5):733-40.
    View in: PubMed
  217. Maron R, Hancock WW, Slavin A, Hattori M, Kuchroo V, Weiner HL. Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines. Int Immunol. 1999 Sep; 11(9):1573-80.
    View in: PubMed
  218. Liu L, Kuchroo VK, Weiner HL. B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance. J Immunol. 1999 Aug 15; 163(4):2284-90.
    View in: PubMed
  219. Stremmel C, Greenfield EA, Howard E, Freeman GJ, Kuchroo VK. B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism. J Exp Med. 1999 Mar 15; 189(6):919-30.
    View in: PubMed
  220. Murtaza A, Kuchroo VK, Freeman GJ. Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands. Int Immunol. 1999 Mar; 11(3):407-16.
    View in: PubMed
  221. Encinas JA, Wicker LS, Peterson LB, Mukasa A, Teuscher C, Sobel R, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. Nat Genet. 1999 Feb; 21(2):158-60.
    View in: PubMed
  222. Encinas JA, Kuchroo VK. Genetics of experimental autoimmune encephalomyelitis. Curr Dir Autoimmun. 1999; 1:247-72.
    View in: PubMed
  223. Kuchroo VK, Weiner HL. Antigen-driven regulation of experimental autoimmune encephalomyelitis. Res Immunol. 1998 Nov-Dec; 149(9):759-71; discussion 842-3, 855-60.
    View in: PubMed
  224. Bettelli E, Das MP, Howard ED, Weiner HL, Sobel RA, Kuchroo VK. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol. 1998 Oct 1; 161(7):3299-306.
    View in: PubMed
  225. Carrizosa AM, Nicholson LB, Farzan M, Southwood S, Sette A, Sobel RA, Kuchroo VK. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J Immunol. 1998 Oct 1; 161(7):3307-14.
    View in: PubMed
  226. Nicholson LB, Waldner H, Carrizosa AM, Sette A, Collins M, Kuchroo VK. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1):264-9.
    View in: PubMed
  227. Greenfield EA, Nguyen KA, Kuchroo VK. CD28/B7 costimulation: a review. Crit Rev Immunol. 1998; 18(5):389-418.
    View in: PubMed
  228. Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ, Hafler DA. Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. J Immunol. 1997 Nov 15; 159(10):4799-805.
    View in: PubMed
  229. Waldner H, Sobel RA, Howard E, Kuchroo VK. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. J Immunol. 1997 Oct 1; 159(7):3100-3.
    View in: PubMed
  230. Das MP, Nicholson LB, Greer JM, Kuchroo VK. Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein. J Exp Med. 1997 Sep 15; 186(6):867-76.
    View in: PubMed
  231. Nicholson LB, Murtaza A, Hafler BP, Sette A, Kuchroo VK. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9279-84.
    View in: PubMed
  232. Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Höllsberg P, Davis G, Hafler DA, Sharpe AH, Freeman GJ, Kuchroo VK. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. J Immunol. 1997 Mar 1; 158(5):2025-34.
    View in: PubMed
  233. Nicholson LB, Kuchroo VK. T cell recognition of self and altered self antigens. Crit Rev Immunol. 1997; 17(5-6):449-62.
    View in: PubMed
  234. Ausubel LJ, Kwan CK, Sette A, Kuchroo V, Hafler DA. Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proc Natl Acad Sci U S A. 1996 Dec 24; 93(26):15317-22.
    View in: PubMed
  235. Nicholson LB, Kuchroo VK. Manipulation of the Th1/Th2 balance in autoimmune disease. Curr Opin Immunol. 1996 Dec; 8(6):837-42.
    View in: PubMed
  236. Das MR, Cohen A, Zamvil SS, Offner H, Kuchroo VK. Prior exposure to superantigen can inhibit or exacerbate autoimmune encephalomyelitis: T-cell repertoire engaged by the autoantigen determines clinical outcome. J Neuroimmunol. 1996 Dec; 71(1-2):3-10.
    View in: PubMed
  237. Ranger AM, Das MP, Kuchroo VK, Glimcher LH. B7-2 (CD86) is essential for the development of IL-4-producing T cells. Int Immunol. 1996 Oct; 8(10):1549-60.
    View in: PubMed
  238. Encinas JA, Weiner HL, Kuchroo VK. Inheritance of susceptibility to experimental autoimmune encephalomyelitis. J Neurosci Res. 1996 Sep 15; 45(6):655-69.
    View in: PubMed
  239. Encinas JA, Lees MB, Sobel RA, Symonowicz C, Greer JM, Shovlin CL, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J Immunol. 1996 Sep 1; 157(5):2186-92.
    View in: PubMed
  240. Hafler DA, Saadeh MG, Kuchroo VK, Milford E, Steinman L. TCR usage in human and experimental demyelinating disease. Immunol Today. 1996 Apr; 17(4):152-9.
    View in: PubMed
  241. Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA, Weiner HL. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci U S A. 1996 Jan 9; 93(1):388-91.
    View in: PubMed
  242. Windhagen A, Nicholson LB, Weiner HL, Kuchroo VK, Hafler DA. Role of Th1 and Th2 cells in neurologic disorders. Chem Immunol. 1996; 63:171-86.
    View in: PubMed
  243. Greer JM, Sobel RA, Sette A, Southwood S, Lees MB, Kuchroo VK. Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. J Immunol. 1996 Jan 1; 156(1):371-9.
    View in: PubMed
  244. Nicholson LB, Greer JM, Sobel RA, Lees MB, Kuchroo VK. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity. 1995 Oct; 3(4):397-405.
    View in: PubMed
  245. Markovic-Plese S, Fukaura H, Zhang J, al-Sabbagh A, Southwood S, Sette A, Kuchroo VK, Hafler DA. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J Immunol. 1995 Jul 15; 155(2):982-92.
    View in: PubMed
  246. Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 1995 Jul 13; 376(6536):177-80.
    View in: PubMed
  247. Kuchroo VK, Byrne MC, Greenfield E, Whitters MJ, Nalefsky EA, Rao A, Collins M, Dorf ME. Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity. J Immunol. 1995 May 15; 154(10):5030-8.
    View in: PubMed
  248. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 1995 Mar 10; 80(5):707-18.
    View in: PubMed
  249. O'Hara RM, Byrne MC, Kuchroo VK, Nagelin A, Whitters MJ, Jayaraman S, Henderson SL, Dorf ME, Collins M. T cell receptor alpha-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction. J Immunol. 1995 Mar 1; 154(5):2075-81.
    View in: PubMed
  250. Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur J Immunol. 1995 Jan; 25(1):207-11.
    View in: PubMed
  251. Kuchroo VK, Greer JM, Kaul D, Ishioka G, Franco A, Sette A, Sobel RA, Lees MB. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J Immunol. 1994 Oct 1; 153(7):3326-36.
    View in: PubMed
  252. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994 Aug 26; 265(5176):1237-40.
    View in: PubMed
  253. Sobel RA, Greer JM, Kuchroo VK. Minireview: autoimmune responses to myelin proteolipid protein. Neurochem Res. 1994 Aug; 19(8):915-21.
    View in: PubMed
  254. Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL, et al. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. J Exp Med. 1994 May 1; 179(5):1659-64.
    View in: PubMed
  255. Franco A, Southwood S, Arrhenius T, Kuchroo VK, Grey HM, Sette A, Ishioka GY. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis. Eur J Immunol. 1994 Apr; 24(4):940-6.
    View in: PubMed
  256. Zamvil SS, al-Sabbagh A, Nelson PA, Kaul D, Charles MS, Mitchell DJ, Steinman L, Weiner HL, Kuchroo VK. 'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis. Pathobiology. 1994; 62(3):113-9.
    View in: PubMed
  257. Kuchroo VK, Martin CA, Greer JM, Ju ST, Sobel RA, Dorf ME. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J Immunol. 1993 Oct 15; 151(8):4371-82.
    View in: PubMed
  258. Byrne MC, O'Hara RM, Kuchroo VK, Jayaraman S, Rao A, Dorf ME, Collins M. The role of the T cell receptor alpha chain in antigen-specific immune suppression. Ann N Y Acad Sci. 1993 Jun 23; 685:611-3.
    View in: PubMed
  259. Ozdemirli M, el-Khatib M, Bastiani L, Akdeniz H, Kuchroo V, Ju ST. The cytotoxic process of CD4 Th1 clones. J Immunol. 1992 Sep 15; 149(6):1889-95.
    View in: PubMed
  260. Sobel RA, Kuchroo VK. The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions. J Immunol. 1992 Aug 15; 149(4):1444-51.
    View in: PubMed
  261. Greer JM, Kuchroo VK, Sobel RA, Lees MB. Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J Immunol. 1992 Aug 1; 149(3):783-8.
    View in: PubMed
  262. Dorf ME, Kuchroo VK, Collins M. Suppressor T cells: some answers but more questions. Immunol Today. 1992 Jul; 13(7):241-3.
    View in: PubMed
  263. Kuchroo VK, Sobel RA, Laning JC, Martin CA, Greenfield E, Dorf ME, Lees MB. Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage. J Immunol. 1992 Jun 15; 148(12):3776-82.
    View in: PubMed
  264. Kuchroo VK, Byrne MC, Atsumi Y, Greenfield E, Connolly JB, Whitters MJ, O'Hara RM, Collins M, Dorf ME. T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function. Proc Natl Acad Sci U S A. 1991 Oct 1; 88(19):8700-4.
    View in: PubMed
  265. Kuchroo VK, Sobel RA, Yamamura T, Greenfield E, Dorf ME, Lees MB. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991; 59(5):305-12.
    View in: PubMed
  266. Gallina MJ, Kuchroo VK, Steele JK. Serologic, biologic, and western blot analysis of a T suppressor factor with specificity for the hapten 4-hydroxy-3-nitrophenyl acetyl derived from serum-free medium. J Immunol. 1990 Dec 1; 145(11):3570-7.
    View in: PubMed
  267. Collins M, Kuchroo VK, Whitters MJ, O'Hara RM, Kelleher K, Kubo RT, Dorf ME. Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function. J Immunol. 1990 Nov 1; 145(9):2809-19.
    View in: PubMed
  268. Wilson SD, Kuchroo VK, Israel DI, Dorf ME. Expression and characterization of TCA3: a murine inflammatory protein. J Immunol. 1990 Oct 15; 145(8):2745-50.
    View in: PubMed
  269. Kuchroo VK, Billings PR, Levine C, Martin CA, Kubo RT, Dorf ME. Antigen-specific and antibody-mediated growth inhibition of suppressor T cell hybridomas. Roles of H-2 and the CD3-T cell receptor-alpha/beta complex. J Immunol. 1990 Aug 15; 145(4):1059-65.
    View in: PubMed
  270. Kuchroo VK, Steele JK, O'Hara RM, Jayaraman S, Selvaraj P, Greenfield E, Kubo RT, Dorf ME. Relationships between antigen-specific helper and inducer suppressor T cell hybridomas. J Immunol. 1990 Jul 15; 145(2):438-48.
    View in: PubMed
  271. Ishikura H, Jayaraman S, Kuchroo V, Diamond B, Saito S, Dorf ME. Functional analysis of cloned macrophage hybridomas. VII. Modulation of suppressor T cell-inducing activity. J Immunol. 1989 Jul 15; 143(2):414-9.
    View in: PubMed
  272. Kuchroo VK, Minami M, Diamond B, Dorf ME. Requirements for suppressor cell activation. Role of accessory cells. J Immunol. 1989 Apr 1; 142(7):2192-9.
    View in: PubMed
  273. Steele JK, Kuchroo VK, Kawasaki H, Jayaraman S, Iwata M, Ishizaka K, Dorf ME. A monoclonal antibody raised to lipomodulin recognizes T suppressor factors in two independent hapten-specific suppressor networks. J Immunol. 1989 Apr 1; 142(7):2213-20.
    View in: PubMed
  274. Kuchroo VK, Steele JK, Billings PR, Selvaraj P, Dorf ME. Expression of CD3-associated antigen-binding receptors on suppressor T cells. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9209-13.
    View in: PubMed
  275. Ishikura H, Kuchroo V, Abromson-Leeman S, Dorf ME. Comparisons between helper and suppressor T-cell induction. Immunol Rev. 1988 Dec; 106:93-114.
    View in: PubMed
  276. Dorf ME, Kuchroo VK, Steele JK, O'Hara RM. Understanding suppressor cells: where have we gone wrong? Int Rev Immunol. 1988 Aug; 3(4):375-92.
    View in: PubMed
  277. Kuchroo VK, Noma T, Minami M, Dorf ME. Down-regulation of suppressor cell induction. Immunology. 1988 Aug; 64(4):633-42.
    View in: PubMed
  278. Kuchroo VK, Minami M, Diamond B, Dorf ME. Functional analysis of cloned macrophage hybridomas. VI. Differential ability to induce immunity or suppression. J Immunol. 1988 Jul 1; 141(1):10-6.
    View in: PubMed
  279. Jaureguiberry B, Liao L, Kuchroo V, Dorf ME, Diamond B. Monoclonal anti-idiotypic antibodies to an I-J interacting molecule inhibit suppression in an H-2 restricted way. J Immunol. 1988 May 15; 140(10):3286-9.
    View in: PubMed
  280. Steele JK, Kawasaki H, Kuchroo VK, Minami M, Levy JG, Dorf ME. A monoclonal antibody raised to tumor-specific T cell-derived suppressor factors also recognizes T suppressor inducer factors of the 4-hydroxy-3-nitrophenyl acetyl hapten suppressor network. J Immunol. 1987 Oct 15; 139(8):2629-34.
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  281. Kuchroo VK, Lee VK, Hellström I, Hellström KE, Halliday WJ. Tumor-specific idiotopes on suppressor factors and suppressor cells revealed by monoclonal anti-idiotope antibodies. Cell Immunol. 1987 Jan; 104(1):105-14.
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  282. Nelson M, Nelson DS, Kuchroo VK, Spradbrow PB, Jennings PA. Depression of cell-mediated immunity by tumour cell products: induction of resistance by immunotherapeutically active extracts of bovine ocular squamous cell carcinoma. Cancer Immunol Immunother. 1987; 24(3):231-6.
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  283. Kuchroo VK, Halliday WJ. Cellular requirements for the suppression of leucocyte adherence inhibition reactions by serum factors from tumour-bearing mice. Immunology. 1986 Apr; 57(4):545-52.
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  284. Lee VK, Harriott TG, Kuchroo VK, Halliday WJ, Hellström I, Hellström KE. Monoclonal antiidiotypic antibodies related to a murine oncofetal bladder tumor antigen induce specific cell-mediated tumor immunity. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6286-90.
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  285. Nelson M, Nelson DS, Spradbrow PB, Kuchroo VK, Jennings PA, Cianciolo GJ, Snyderman R. Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms. Clin Exp Immunol. 1985 Jul; 61(1):109-17.
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  286. Kuchroo VK, Spradbrow PB. Tumour-associated antigens in bovine ocular squamous cell carcinoma: studies with sera from tumour-bearing animals. Vet Immunol Immunopathol. 1985 May; 9(1):23-36.
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  287. Kuchroo VK, Halliday WJ, Jennings PA, Spradbrow PB. Serum blocking factors in bovine ocular squamous cell carcinoma demonstrated by inhibition of erythrocyte rosette augmentation. Cancer Res. 1983 Mar; 43(3):1325-9.
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  288. Kuchroo VK, Jennings PA, Spradbrow PB. Bovine ocular squamous cell carcinoma: tumor-associated immunity detected by E-rosette augmentation test. J Natl Cancer Inst. 1983 Feb; 70(2):305-9.
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  289. Kuchroo VK, Jennings PA. Rosetting of bovine T-lymphocytes with autologous and allogeneic red blood cells. Vet Immunol Immunopathol. 1982 Sep; 3(5):461-74.
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  290. Kuchroo VK, Dutta BM, Gupta RK. Tumour associated antigens in bovine horn cancer. Aust Vet J. 1982 Jan; 58(1):16-9.
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  291. Kuchroo V, Gupta RK, Kalra DS. Thymus derived rosette forming cell counts and lymphocyte response to phytohaemagglutinin in animals affected with squamous cell carcinoma of horn. Res Vet Sci. 1981 Sep; 31(2):144-6.
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  292. Gupta RK, Sadana JR, Kuchroo VK, Kalra DS. Horn cancer in an intact bull. Vet Rec. 1980 Sep 27; 107(13):312.
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  293. Kuchroo V, Gupta RK, Kalra DS. Antigenic similarity between squamous cell carcinoma of horn (horn cancer) and normal bovine foetal tissues. Trop Anim Health Prod. 1979 Nov; 11(4):203-7.
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