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Zoltan Pierre Arany, M.D.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Ecls906
330 Brookline Ave
Boston MA 02215
Phone617/735-4252

 Overview 
 overview
The lab focuses on gene regulatory events underlying cardiovascular metabolism. The heart and skeletal muscle are highly metabolically active tissues, and are accordingly richly supplied by blood vessels. We have recently identified important molecular regulatory links between cardiac or skeletal muscle metabolism and vascular homeostasis. The pathways have led us to new insights into peripheral vascular disease, exercise physiology, and most recently peripartum cardiomyopathy. Projects are available for medical and graduate students, ranging from molecular biology, to animal experiments and human biomarker or genetic studies.


 Mentoring 
 current student opportunities
Available: 09/01/11, Expires: 09/01/14

All metabolites must pass through blood vessels to enter or leave tissues. We have an active program investigating metabolism in vascular cells. Various opportunities exist for medical students to participate, ranging from molecular projects to small molecule screens.

Available: 09/01/11, Expires: 09/01/14

Peripartum Cardiomyopathy (PPCM) is a significant cause of morbidity and mortality in pregnant women worldwide. We have an active research program delving into the causes of this disease. There are opportunities for medical students to get involved at multiple stages, ranging from molecular biology to establishing tissue/plasma cohorts for biomarker and genetic analyses.

Available: 10/31/12, Expires: 10/31/14

Pregnancy poses unique stresses to the maternal heart, occasionally leading to heart failure, cardiomyopathy, or even death. Little is understood of the normal and pathologic cardiac events surrounding pregnancy.

Various projects are available:
1. Patient record evaluations to identify risk factors for the development of peripartum cardiomyopathy
2. Echocardiographic studies to evaluate cardiac function in the peripartum period
3. Mouse and genetic studies to probe mechanisms underlying cardiac physiology and pathology in pregnancy.
4. Molecular/cellular biology investigations into the vascular and metabolic mechanisms of cardiac function.

 completed student projects
PGC-1á may promote tumor growth through activation of ERRá mediated VEGF transcription.
Summer, 04/28/08 - 09/09/08
The Role of Macrophages in PGC-1α Induced Angiogenesis in Skeletal Muscle
Summer, 06/20/11 - 08/12/11

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Icli B, Wara AK, Moslehi J, Sun X, Plovie E, Cahill M, Marchini JF, Schissler A, Padera RF, Shi J, Cheng HW, Raghuram S, Arany Z, Liao R, Croce K, Macrae C, Feinberg MW. MicroRNA-26a Regulates Pathological and Physiological Angiogenesis by Targeting BMP/SMAD1 Signaling. Circ Res. 2013 Nov 8; 113(11):1231-41.
    View in: PubMed
  2. Bello N, Rendon IS, Arany Z. The relationship between pre-eclampsia and peripartum cardiomyopathy: a systematic review and meta-analysis. J Am Coll Cardiol. 2013 Oct 29; 62(18):1715-23.
    View in: PubMed
  3. Jang C, Arany Z. Metabolism: Sweet enticements to move. Nature. 2013 Aug 22; 500(7463):409-11.
    View in: PubMed
  4. Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting Mitochondrial Content from Respiratory Chain Capacity in PGC-1-Deficient Skeletal Muscle. Cell Rep. 2013 May 30; 3(5):1449-56.
    View in: PubMed
  5. Rana S, Schnettler WT, Powe C, Wenger J, Salahuddin S, Cerdeira AS, Verlohren S, Perschel FH, Arany Z, Lim KH, Thadhani R, Karumanchi SA. Clinical characterization and outcomes of preeclampsia with normal angiogenic profile. Hypertens Pregnancy. 2013 May; 32(2):189-201.
    View in: PubMed
  6. Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR. Oncogenic BRAF Regulates Oxidative Metabolism via PGC1a and MITF. Cancer Cell. 2013 Mar 18; 23(3):302-15.
    View in: PubMed
  7. Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. PGC-1 Coactivators Regulate MITF and the Tanning Response. Mol Cell. 2013 Jan 10; 49(1):145-57.
    View in: PubMed
  8. Saint-Geniez M, Jiang A, Abend S, Liu L, Sweigard H, Connor KM, Arany Z. PGC-1a Regulates Normal and Pathological Angiogenesis in the Retina. Am J Pathol. 2013 Jan; 182(1):255-65.
    View in: PubMed
  9. Shahul S, Rhee J, Hacker MR, Gulati G, Mitchell JD, Hess P, Mahmood F, Arany Z, Rana S, Talmor D. Subclinical Left Ventricular Dysfunction in Preeclamptic Women With Preserved Left Ventricular Ejection Fraction: A 2D Speckle-Tracking Imaging Study. Circ Cardiovasc Imaging. 2012 Nov 1; 5(6):734-9.
    View in: PubMed
  10. Rowe GC, El-Khoury R, Patten IS, Rustin P, Arany Z. PGC-1a is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle. PLoS One. 2012; 7(7):e41817.
    View in: PubMed
  11. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature. 2012 May 17; 485(7398):333-8.
    View in: PubMed
  12. Hoeks J, Arany Z, Phielix E, Moonen-Kornips E, Hesselink MK, Schrauwen P. Enhanced lipid-but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1a overexpressing mice. J Cell Physiol. 2012 Mar; 227(3):1026-33.
    View in: PubMed
  13. Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Skeletal muscle transcriptional coactivator PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2931-6.
    View in: PubMed
  14. Patten IS, Arany Z. PGC-1 coactivators in the cardiovascular system. Trends Endocrinol Metab. 2012 Feb; 23(2):90-7.
    View in: PubMed
  15. McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA. Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature. 2011 Oct 6; 478(7367):114-8.
    View in: PubMed
  16. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011 Oct; 121(10):4003-14.
    View in: PubMed
  17. Rowe GC, Jang C, Patten IS, Arany Z. PGC-1ß regulates angiogenesis in skeletal muscle. Am J Physiol Endocrinol Metab. 2011 Jul; 301(1):E155-63.
    View in: PubMed
  18. LeBrasseur NK, Walsh K, Arany Z. Metabolic benefits of resistance training and fast glycolytic skeletal muscle. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E3-10.
    View in: PubMed
  19. Rowe GC, Jiang A, Arany Z. PGC-1 coactivators in cardiac development and disease. Circ Res. 2010 Oct 1; 107(7):825-38.
    View in: PubMed
  20. Menconi MJ, Arany ZP, Alamdari N, Aversa Z, Gonnella P, O'Neal P, Smith IJ, Tizio S, Hasselgren PO. Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle. Am J Physiol Endocrinol Metab. 2010 Oct; 299(4):E533-43.
    View in: PubMed
  21. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010 May 26; 2(33):33ra37.
    View in: PubMed
  22. Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Transcriptional control of preadipocyte determination by Zfp423. Nature. 2010 Mar 25; 464(7288):619-23.
    View in: PubMed
  23. Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, Sawada N, Raghuram S, Arany Z. The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21401-6.
    View in: PubMed
  24. Shoag J, Arany Z. Regulation of hypoxia-inducible genes by PGC-1 alpha. Arterioscler Thromb Vasc Biol. 2010 Apr; 30(4):662-6.
    View in: PubMed
  25. Gonçalves DA, Lira EC, Baviera AM, Cao P, Zanon NM, Arany Z, Bedard N, Tanksale P, Wing SS, Lecker SH, Kettelhut IC, Navegantes LC. Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle. Endocrinology. 2009 Dec; 150(12):5395-404.
    View in: PubMed
  26. Sawada N, Itoh H, Miyashita K, Tsujimoto H, Sone M, Yamahara K, Arany ZP, Hofmann F, Nakao K. Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels. Mol Cell Biol. 2009 Nov; 29(22):6018-32.
    View in: PubMed
  27. Wagner BK, Arany Z. High-throughput real-time PCR for detection of gene-expression levels. Methods Mol Biol. 2009; 486:167-75.
    View in: PubMed
  28. Arany Z. PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev. 2008 Oct; 18(5):426-34.
    View in: PubMed
  29. Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem. 2008 Nov 14; 283(46):31960-7.
    View in: PubMed
  30. Arany ZP. High-throughput quantitative real-time PCR. Curr Protoc Hum Genet. 2008 Jul; Chapter 11:Unit 11.10.
    View in: PubMed
  31. Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4721-6.
    View in: PubMed
  32. Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 2008 Feb 21; 451(7181):1008-12.
    View in: PubMed
  33. Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, Spiegelman BM. The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 2007 Jan; 5(1):35-46.
    View in: PubMed
  34. Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM. PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16260-5.
    View in: PubMed
  35. Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM. Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):10086-91.
    View in: PubMed
  36. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005 Apr; 1(4):259-71.
    View in: PubMed
  37. Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 1999 Jan 1; 13(1):64-75.
    View in: PubMed
  38. Huang LE, Ho V, Arany Z, Krainc D, Galson D, Tendler D, Livingston DM, Bunn HF. Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors. Kidney Int. 1997 Feb; 51(2):548-52.
    View in: PubMed
  39. Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem. 1996 Dec 13; 271(50):32253-9.
    View in: PubMed
  40. Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, Livingston DM. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12969-73.
    View in: PubMed
  41. Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston DM. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature. 1996 Sep 26; 383(6598):344-7.
    View in: PubMed
  42. Eckner R, Ludlow JW, Lill NL, Oldread E, Arany Z, Modjtahedi N, DeCaprio JA, Livingston DM, Morgan JA. Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol. 1996 Jul; 16(7):3454-64.
    View in: PubMed
  43. Kitabayashi I, Eckner R, Arany Z, Chiu R, Gachelin G, Livingston DM, Yokoyama KK. Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells. EMBO J. 1995 Jul 17; 14(14):3496-509.
    View in: PubMed
  44. Arany Z, Newsome D, Oldread E, Livingston DM, Eckner R. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature. 1995 Mar 2; 374(6517):81-4.
    View in: PubMed
  45. Qin XQ, Livingston DM, Ewen M, Sellers WR, Arany Z, Kaelin WG. The transcription factor E2F-1 is a downstream target of RB action. Mol Cell Biol. 1995 Feb; 15(2):742-55.
    View in: PubMed
  46. Krek W, Ewen ME, Shirodkar S, Arany Z, Kaelin WG, Livingston DM. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell. 1994 Jul 15; 78(1):161-72.
    View in: PubMed
  47. Arany Z, Sellers WR, Livingston DM, Eckner R. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell. 1994 Jun 17; 77(6):799-800.
    View in: PubMed
  48. Eckner R, Arany Z, Ewen M, Sellers W, Livingston DM. The adenovirus E1A-associated 300-kD protein exhibits properties of a transcriptional coactivator and belongs to an evolutionarily conserved family. Cold Spring Harb Symp Quant Biol. 1994; 59:85-95.
    View in: PubMed
  49. Smith CM, Arany Z, Orrego C, Eisenstadt E. Mutations in topA interfere with the inducible expression of DNA damage response loci in Salmonella typhimurium. Environ Mol Mutagen. 1992; 19(3):185-94.
    View in: PubMed
  50. Smith CM, Arany Z, Orrego C, Eisenstadt E. DNA damage-inducible loci in Salmonella typhimurium. J Bacteriol. 1991 Jun; 173(11):3587-90.
    View in: PubMed
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