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Kevin Carl Eggan, Ph.D.

TitleProfessor of Stem Cell and Regenerative Biology
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressHarvard, FAS Molecular & Cell Biology
Sherman Fairchild Biochemistry Bldg
7 Divinity Ave
Cambridge MA 02138
Phone617/496-5611

 Research 
 research resources
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eagle-i@hms.harvard.edu.
Eggan Lab - iPS cells (17)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K. How to make spinal motor neurons. Development. 2014 Feb; 141(3):491-501.
    View in: PubMed
  2. Eggan K. Picking the lock on pluripotency. N Engl J Med. 2013 Nov 28; 369(22):2150-1.
    View in: PubMed
  3. Navara CS, Hornecker J, Grow D, Chaudhari S, Hornsby PJ, Ichida JK, Eggan K, McCarrey JR. Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies. Cell Reprogram. 2013 Dec; 15(6):495-502.
    View in: PubMed
  4. Suzuki N, Maroof AM, Merkle FT, Koszka K, Intoh A, Armstrong I, Moccia R, Davis-Dusenbery BN, Eggan K. The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD. Nat Neurosci. 2013 Dec; 16(12):1725-7.
    View in: PubMed
  5. Sandoe J, Eggan K. Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat Neurosci. 2013 Jun 25; 16(7):780-9.
    View in: PubMed
  6. Merkle FT, Eggan K. Modeling human disease with pluripotent stem cells: from genome association to function. Cell Stem Cell. 2013 Jun 6; 12(6):656-68.
    View in: PubMed
  7. Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell. 2013 May 2; 12(5):559-72.
    View in: PubMed
  8. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28; 495(7442):474-80.
    View in: PubMed
  9. Niakan KK, Eggan K. Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse. Dev Biol. 2013 Mar 1; 375(1):54-64.
    View in: PubMed
  10. Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW, Livet J, Stern JN, Sanes JR, Eggan K. Developmental bias in cleavage-stage mouse blastomeres. Curr Biol. 2013 Jan 7; 23(1):21-31.
    View in: PubMed
  11. Williams LA, Davis-Dusenbery BN, Eggan KC. SnapShot: directed differentiation of pluripotent stem cells. Cell. 2012 May 25; 149(5):1174-1174.e1.
    View in: PubMed
  12. Mekhoubad S, Bock C, de Boer AS, Kiskinis E, Meissner A, Eggan K. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell. 2012 May 4; 10(5):595-609.
    View in: PubMed
  13. Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun. 2011; 2:488.
    View in: PubMed
  14. Egli D, Chen AE, Saphier G, Powers D, Alper M, Katz K, Berger B, Goland R, Leibel RL, Melton DA, Eggan K. Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell. 2011 Oct 4; 9(4):293-4.
    View in: PubMed
  15. Seandel M, Eggan K. Stem Cells: Doing Some Heavy Lifting at ISSCR 2011. Cell Stem Cell. 2011 Oct 4; 9(4):311-5.
    View in: PubMed
  16. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 2011 Sep 2; 9(3):205-18.
    View in: PubMed
  17. Han SS, Williams LA, Eggan KC. Constructing and deconstructing stem cell models of neurological disease. Neuron. 2011 May 26; 70(4):626-44.
    View in: PubMed
  18. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 3; 471(7336):63-7.
    View in: PubMed
  19. Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A. Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell. 2011 Feb 4; 144(3):439-52.
    View in: PubMed
  20. Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol. 2011 Mar; 29(3):279-86.
    View in: PubMed
  21. Ichida JK, Kiskinis E, Eggan K. Shushing down the epigenetic landscape towards stem cell differentiation. Development. 2010 Aug 1; 137(15):2455-60.
    View in: PubMed
  22. Egli D, Eggan K. Recipient cell nuclear factors are required for reprogramming by nuclear transfer. Development. 2010 Jun; 137(12):1953-63.
    View in: PubMed
  23. Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010 Feb 1; 24(3):312-26.
    View in: PubMed
  24. Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest. 2010 Jan; 120(1):51-9.
    View in: PubMed
  25. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 6; 5(5):491-503.
    View in: PubMed
  26. Egli D, Sandler VM, Shinohara ML, Cantor H, Eggan K. Reprogramming after chromosome transfer into mouse blastomeres. Curr Biol. 2009 Aug 25; 19(16):1403-9.
    View in: PubMed
  27. Zhang K, Li JB, Gao Y, Egli D, Xie B, Deng J, Li Z, Lee JH, Aach J, Leproust EM, Eggan K, Church GM. Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nat Methods. 2009 Aug; 6(8):613-8.
    View in: PubMed
  28. Deng J, Shoemaker R, Xie B, Gore A, LeProust EM, Antosiewicz-Bourget J, Egli D, Maherali N, Park IH, Yu J, Daley GQ, Eggan K, Hochedlinger K, Thomson J, Wang W, Gao Y, Zhang K. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol. 2009 Apr; 27(4):353-60.
    View in: PubMed
  29. Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 2009 Feb 6; 4(2):103-6.
    View in: PubMed
  30. Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell. 2008 Dec 4; 3(6):637-48.
    View in: PubMed
  31. Eggan K. Using stem cells and reprogramming to understand disease. Regen Med. 2008 Nov; 3(6):799-801.
    View in: PubMed
  32. Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science. 2008 Aug 29; 321(5893):1218-21.
    View in: PubMed
  33. Egli D, Birkhoff G, Eggan K. Mediators of reprogramming: transcription factors and transitions through mitosis. Nat Rev Mol Cell Biol. 2008 Jul; 9(7):505-16.
    View in: PubMed
  34. Eggan K. Short-circuiting epiblast development. Cell Stem Cell. 2007 Aug 16; 1(2):131-2.
    View in: PubMed
  35. Egli D, Rosains J, Birkhoff G, Eggan K. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature. 2007 Jun 7; 447(7145):679-85.
    View in: PubMed
  36. Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci. 2007 May; 10(5):608-14.
    View in: PubMed
  37. Eggan K. Dolly's legacy: human nuclear transplantation and better medicines for our children. Cloning Stem Cells. 2007; 9(1):21-5.
    View in: PubMed
  38. Egli D, Eggan K. Nuclear transfer into mouse oocytes. J Vis Exp. 2006 Dec; (1):116.
    View in: PubMed
  39. Trish E, Dimos J, Eggan K. Human ES cells: starting culture from frozen cells. J Vis Exp. 2006 Dec; (1):86.
    View in: PubMed
  40. Trish E, Dimos J, Eggan K. Passaging HuES human embryonic stem cell-lines with trypsin. J Vis Exp. 2006 Dec; (1):49.
    View in: PubMed
  41. Trish E, Dimos J, Eggan K. Freezing human ES cells. J Vis Exp. 2006 Dec; (1):50.
    View in: PubMed
  42. Rodolfa KT, Eggan K. A transcriptional logic for nuclear reprogramming. Cell. 2006 Aug 25; 126(4):652-5.
    View in: PubMed
  43. Eggan K, Jurga S, Gosden R, Min IM, Wagers AJ. Ovulated oocytes in adult mice derive from non-circulating germ cells. Nature. 2006 Jun 29; 441(7097):1109-14.
    View in: PubMed
  44. Yang X, Eggan K, Seidel G, Jaenisch R, Melton D. A simple system of checks and balances to cut fraud. Nature. 2006 Feb 16; 439(7078):782.
    View in: PubMed
  45. Sullivan S, Eggan K. The potential of cell fusion for human therapy. Stem Cell Rev. 2006; 2(4):341-9.
    View in: PubMed
  46. Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science. 2005 Aug 26; 309(5739):1369-73.
    View in: PubMed
  47. Jaenisch R, Hochedlinger K, Eggan K. Nuclear cloning, epigenetic reprogramming and cellular differentiation. Novartis Found Symp. 2005; 265:107-18; discussion 118-28.
    View in: PubMed
  48. Eggan K, Baldwin K, Tackett M, Osborne J, Gogos J, Chess A, Axel R, Jaenisch R. Mice cloned from olfactory sensory neurons. Nature. 2004 Mar 4; 428(6978):44-9.
    View in: PubMed
  49. Jaenisch R, Hochedlinger K, Blelloch R, Yamada Y, Baldwin K, Eggan K. Nuclear cloning, epigenetic reprogramming, and cellular differentiation. Cold Spring Harb Symp Quant Biol. 2004; 69:19-27.
    View in: PubMed
  50. Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ. Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature. 2004 Jan 8; 427(6970):148-54.
    View in: PubMed
  51. Eggan K, Jaenisch R. Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation. Semin Cell Dev Biol. 2003 Dec; 14(6):349-58.
    View in: PubMed
  52. Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC, Jaenisch R. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. 2003 Apr; 130(8):1673-80.
    View in: PubMed
  53. Eggan K, Jaenisch R. Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. Methods Enzymol. 2003; 365:25-39.
    View in: PubMed
  54. Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20):12889-94.
    View in: PubMed
  55. Eggan K, Rode A, Jentsch I, Samuel C, Hennek T, Tintrup H, Zevnik B, Erwin J, Loring J, Jackson-Grusby L, Speicher MR, Kuehn R, Jaenisch R. Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. Nat Biotechnol. 2002 May; 20(5):455-9.
    View in: PubMed
  56. Biniszkiewicz D, Gribnau J, Ramsahoye B, Gaudet F, Eggan K, Humpherys D, Mastrangelo MA, Jun Z, Walter J, Jaenisch R. Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Mol Cell Biol. 2002 Apr; 22(7):2124-35.
    View in: PubMed
  57. Possemato R, Eggan K, Moeller BJ, Jaenisch R, Jackson-Grusby L. Flp recombinase regulated lacZ expression at the ROSA26 locus. Genesis. 2002 Feb; 32(2):184-6.
    View in: PubMed
  58. Jeanisch R, Eggan K, Humpherys D, Rideout W, Hochedlinger K. Nuclear cloning, stem cells, and genomic reprogramming. Cloning Stem Cells. 2002; 4(4):389-96.
    View in: PubMed
  59. Rideout WM, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science. 2001 Aug 10; 293(5532):1093-8.
    View in: PubMed
  60. Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM, Biniszkiewicz D, Yanagimachi R, Jaenisch R. Epigenetic instability in ES cells and cloned mice. Science. 2001 Jul 6; 293(5527):95-7.
    View in: PubMed
  61. Eggan K, Akutsu H, Loring J, Jackson-Grusby L, Klemm M, Rideout WM, Yanagimachi R, Jaenisch R. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6209-14.
    View in: PubMed
  62. Eggan K, Akutsu H, Hochedlinger K, Rideout W, Yanagimachi R, Jaenisch R. X-Chromosome inactivation in cloned mouse embryos. Science. 2000 Nov 24; 290(5496):1578-81.
    View in: PubMed
  63. Rideout WM, Wakayama T, Wutz A, Eggan K, Jackson-Grusby L, Dausman J, Yanagimachi R, Jaenisch R. Generation of mice from wild-type and targeted ES cells by nuclear cloning. Nat Genet. 2000 Feb; 24(2):109-10.
    View in: PubMed
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