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Keywords
Last Name
Institution

Leonard Ira Zon, M.D.

TitleProfessor of Stem Cell and Regenerative Biology
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressChildrens Hospital
Karp Family Research Laboratories, 7th Floor
300 Longwood Ave
Boston MA 02115
Phone617/919-2069
Fax617/730-0222
Other Positions
TitleProfessor of Stem Cell and Regenerative Biology and Grousbeck Professor of Pediatrics, Harvard Medical School
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regen Bio

TitleGrousbeck Professor of Pediatrics
InstitutionChildren's Hospital Boston
DepartmentPediatrics


 Mentoring 
 current student opportunities
Hematopoiesis and Cancer[login at prompt]
Available: 07/01/12, Expires: 08/31/13

The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken chemical genetic approach to blood development and have found that prostaglandins upregulates blood stem cells. This has led to a clinical trial to improve engraftment for patients receiving cord blood transplants. We recently developed suppressor screening genetics and found that transcriptional elongation regulates blood cell fate. The laboratory has also developed zebrafish models of cancer. We have generated a melanoma model in the zebrafish system using transgenics. Transgenic fish get nevi, and in a combination with a p53 mutant fish develop melanomas. We recently found a histone methyltransferase that can accelerate melanoma, and discovered a small molecule that blocks transcription elongation and suppresses melanoma growth.

 completed student projects
Tracing Hematopoetic Stem Cells in Zebrafish
Summer, 07/01/01 - 08/31/01
SMAD1 and GATA1 Protein Interactions in the Myeloid Lineage
Summer, 06/11/12 - 08/10/12
Characterization of the Role of Angiopoietin-Like Proteins in Blood Stem Cell Development
Summer, 01/12/09 - 08/27/09
Melanocyte and Melanoma Regulation
Summer, 06/20/11 - 08/12/11

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ciarlo CA, Zon LI. A Model for Primary Melanoma of the CNS Implicates NRAS. Cancer Discov. 2013 Apr; 3(4):382-3.
    View in: PubMed
  2. Bowman TV, Zon LI. Ageing: Stem cells on a stress-busting diet. Nature. 2013 Feb 21; 494(7437):317-8.
    View in: PubMed
  3. Kim PG, Albacker CE, Lu YF, Jang IH, Lim Y, Heffner GC, Arora N, Bowman TV, Lin MI, Lensch MW, De Los Angeles A, Zon LI, Loewer S, Daley GQ. Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2):E141-50.
    View in: PubMed
  4. Jing CB, Chen Y, Dong M, Peng XL, Jia XE, Gao L, Ma K, Deng M, Liu TX, Zon LI, Zhu J, Zhou Y, Zhou Y. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Dev Biol. 2013 Feb 1; 374(1):24-31.
    View in: PubMed
  5. Bai X, Trowbridge JJ, Riley E, Lee JA, Dibiase A, Kaartinen VM, Orkin SH, Zon LI. TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013 Jan 15; 373(2):422-30.
    View in: PubMed
  6. McKinney-Freeman S, Cahan P, Li H, Lacadie SA, Huang HT, Curran M, Loewer S, Naveiras O, Kathrein KL, Konantz M, Langdon EM, Lengerke C, Zon LI, Collins JJ, Daley GQ. The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 2012 Nov 2; 11(5):701-14.
    View in: PubMed
  7. Mochida GH, Ganesh VS, de Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D, Hill AD, Malik AN, Barry BJ, Partlow JN, Tan WH, Glader LJ, Barkovich AJ, Dobyns WB, Zon LI, Walsh CA. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet. 2012 Nov; 44(11):1260-4.
    View in: PubMed
  8. Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46.
    View in: PubMed
  9. Sorrells S, Carbonneau S, Harrington E, Chen AT, Hast B, Milash B, Pyati U, Major MB, Zhou Y, Zon LI, Stewart RA, Look AT, Jette C. Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53. PLoS Genet. 2012; 8(8):e1002922.
    View in: PubMed
  10. Oubaha M, Lin MI, Margaron Y, Filion D, Price EN, Zon LI, Côté JF, Gratton JP. Formation of a PKC?/ß-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Blood. 2012 Oct 18; 120(16):3371-81.
    View in: PubMed
  11. Cooney JD, Hildick-Smith GJ, Shafizadeh E, McBride PF, Carroll KJ, Anderson H, Shaw GC, Tamplin OJ, Branco DS, Dalton AJ, Shah DI, Wong C, Gallagher PG, Zon LI, North TE, Paw BH. Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev Biol. 2013 Jan 15; 373(2):431-41.
    View in: PubMed
  12. Gupta VA, Kawahara G, Myers JA, Chen AT, Hall TE, Manzini MC, Currie PD, Zhou Y, Zon LI, Kunkel LM, Beggs AH. A splice site mutation in laminin-a2 results in a severe muscular dystrophy and growth abnormalities in zebrafish. PLoS One. 2012; 7(8):e43794.
    View in: PubMed
  13. Mione M, Zon LI. Cancer and inflammation: an aspirin a day keeps the cancer at bay. Curr Biol. 2012 Jul 10; 22(13):R522-5.
    View in: PubMed
  14. Santoriello C, Zon LI. Hooked! Modeling human disease in zebrafish. J Clin Invest. 2012 Jul 2; 122(7):2337-43.
    View in: PubMed
  15. de Jong JL, Zon LI. Histocompatibility and hematopoietic transplantation in the zebrafish. Adv Hematol. 2012; 2012:282318.
    View in: PubMed
  16. Zon LI. A great match. Cell Stem Cell. 2012 Jun 14; 10(6):638-9.
    View in: PubMed
  17. Ganis JJ, Hsia N, Trompouki E, de Jong JL, DiBiase A, Lambert JS, Jia Z, Sabo PJ, Weaver M, Sandstrom R, Stamatoyannopoulos JA, Zhou Y, Zon LI. Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol. 2012 Jun 15; 366(2):185-94.
    View in: PubMed
  18. Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer J, Xiong F, Torregroza I, Evans T, Megason SG, Daley GQ, Schier AF, Young RA, Zon LI. Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Dev Cell. 2012 Mar 13; 22(3):625-38.
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  19. Yu M, Mazor T, Huang H, Huang HT, Kathrein KL, Woo AJ, Chouinard CR, Labadorf A, Akie TE, Moran TB, Xie H, Zacharek S, Taniuchi I, Roeder RG, Kim CF, Zon LI, Fraenkel E, Cantor AB. Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell. 2012 Feb 10; 45(3):330-43.
    View in: PubMed
  20. Bowman TV, Trompouki E, Zon LI. Linking hematopoietic regeneration to developmental signaling pathways: a story of BMP and Wnt. Cell Cycle. 2012 Feb 1; 11(3):424-5.
    View in: PubMed
  21. Shestopalov IA, Zon LI. Stem cells: The right neighbour. Nature. 2012 Jan 26; 481(7382):453-5.
    View in: PubMed
  22. Martin CS, Moriyama A, Zon LI. Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model. Genome Med. 2011; 3(12):83.
    View in: PubMed
  23. Brown KH, Dobrinski KP, Lee AS, Gokcumen O, Mills RE, Shi X, Chong WW, Chen JY, Yoo P, David S, Peterson SM, Raj T, Choy KW, Stranger BE, Williamson RE, Zon LI, Freeman JL, Lee C. Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):529-34.
    View in: PubMed
  24. Zhang L, Alt C, Li P, White RM, Zon LI, Wei X, Lin CP. An optical platform for cell tracking in adult zebrafish. Cytometry A. 2012 Feb; 81(2):176-82.
    View in: PubMed
  25. Taylor AM, Humphries JM, White RM, Murphey RD, Burns CE, Zon LI. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol. 2012 Mar; 40(3):228-237.e5.
    View in: PubMed
  26. Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell. 2011 Oct 28; 147(3):577-89.
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  27. Bugeon L, Taylor HB, Progatzky F, Lin MI, Ellis CD, Welsh N, Smith E, Vargesson N, Gray C, Renshaw SA, Chico TJ, Zon LI, Lamb J, Dallman MJ. The NOTCH pathway contributes to cell fate decision in myelopoiesis. Haematologica. 2011 Dec; 96(12):1753-60.
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  28. Jing L, Zon LI. Zebrafish as a model for normal and malignant hematopoiesis. Dis Model Mech. 2011 Jul; 4(4):433-8.
    View in: PubMed
  29. Adatto I, Lawrence C, Thompson M, Zon LI. A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos. PLoS One. 2011; 6(6):e21715.
    View in: PubMed
  30. Glass TJ, Lund TC, Patrinostro X, Tolar J, Bowman TV, Zon LI, Blazar BR. Stromal cell-derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation. Blood. 2011 Jul 21; 118(3):766-74.
    View in: PubMed
  31. Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TE. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell. 2011 Apr 8; 8(4):445-58.
    View in: PubMed
  32. Taylor AM, Zon LI. Modeling Diamond Blackfan anemia in the zebrafish. Semin Hematol. 2011 Apr; 48(2):81-8.
    View in: PubMed
  33. Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 2011 Mar 24; 471(7339):513-7.
    View in: PubMed
  34. White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 2011 Mar 24; 471(7339):518-22.
    View in: PubMed
  35. Stachura DL, Svoboda O, Lau RP, Balla KM, Zon LI, Bartunek P, Traver D. Clonal analysis of hematopoietic progenitor cells in the zebrafish. Blood. 2011 Aug 4; 118(5):1274-82.
    View in: PubMed
  36. de Jong JL, Burns CE, Chen AT, Pugach E, Mayhall EA, Smith AC, Feldman HA, Zhou Y, Zon LI. Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 2011 Apr 21; 117(16):4234-42.
    View in: PubMed
  37. Bolli N, Payne EM, Rhodes J, Gjini E, Johnston AB, Guo F, Lee JS, Stewart RA, Kanki JP, Chen AT, Zhou Y, Zon LI, Look AT. cpsf1 is required for definitive HSC survival in zebrafish. Blood. 2011 Apr 14; 117(15):3996-4007.
    View in: PubMed
  38. Alexander MS, Kawahara G, Kho AT, Howell MH, Pusack TJ, Myers JA, Montanaro F, Zon LI, Guyon JR, Kunkel LM. Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors. Muscle Nerve. 2011 May; 43(5):741-50.
    View in: PubMed
  39. Lacadie SA, Zon LI. The ERGonomics of hematopoietic stem cell self-renewal. Genes Dev. 2011 Feb 15; 25(4):289-93.
    View in: PubMed
  40. Gupta V, Kawahara G, Gundry SR, Chen AT, Lencer WI, Zhou Y, Zon LI, Kunkel LM, Beggs AH. The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies. Hum Mol Genet. 2011 May 1; 20(9):1712-25.
    View in: PubMed
  41. Li P, White RM, Zon LI. Transplantation in zebrafish. Methods Cell Biol. 2011; 105:403-17.
    View in: PubMed
  42. Mosimann C, Zon LI. Advanced zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments. Methods Cell Biol. 2011; 104:173-94.
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  43. Tan JL, Zon LI. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2011; 105:493-516.
    View in: PubMed
  44. Bai X, Yang Z, Jiang H, Lin S, Zon LI. Genetic suppressor screens in haploids. Methods Cell Biol. 2011; 104:129-36.
    View in: PubMed
  45. Detrich HW, Westerfield M, Zon LI. The zebrafish. Preface. Methods Cell Biol. 2011; 105:xxi-xxii.
    View in: PubMed
  46. Zhou Y, Zon LI. The zon laboratory guide to positional cloning in zebrafish. Methods Cell Biol. 2011; 104:287-309.
    View in: PubMed
  47. Trompouki E, Bowman TV, Dibiase A, Zhou Y, Zon LI. Chromatin immunoprecipitation in adult zebrafish red cells. Methods Cell Biol. 2011; 104:341-52.
    View in: PubMed
  48. Li P, Zon LI. Stem cell migration: a zebrafish model. Methods Mol Biol. 2011; 750:157-68.
    View in: PubMed
  49. Mosimann C, Kaufman CK, Li P, Pugach EK, Tamplin OJ, Zon LI. Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development. 2011 Jan; 138(1):169-77.
    View in: PubMed
  50. Durand EM, Zon LI. Stem cells: The blood balance. Nature. 2010 Dec 2; 468(7324):644-5.
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  51. Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66.
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  52. North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, Goessling W. PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17315-20.
    View in: PubMed
  53. Tamplin OJ, Zon LI. Fishing at the cellular level. Nat Methods. 2010 Aug; 7(8):600-1.
    View in: PubMed
  54. Tamplin OJ, Zon LI. Blood flow: metalloproteases cut loose in primitive erythrocytes. Curr Biol. 2010 Jul 13; 20(13):R561-2.
    View in: PubMed
  55. Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 9; 142(1):133-43.
    View in: PubMed
  56. Durand EM, Zon LI. Newly emerging roles for prostaglandin E2 regulation of hematopoiesis and hematopoietic stem cell engraftment. Curr Opin Hematol. 2010 Jul; 17(4):308-12.
    View in: PubMed
  57. Koo S, Huntly BJ, Wang Y, Chen J, Brumme K, Ball B, McKinney-Freeman SL, Yabuuchi A, Scholl C, Bansal D, Zon LI, Fröhling S, Daley GQ, Gilliland DG, Mercher T. Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis. Haematologica. 2010 Oct; 95(10):1642-50.
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  58. Storer NY, Zon LI. Zebrafish models of p53 functions. Cold Spring Harb Perspect Biol. 2010 Aug; 2(8):a001123.
    View in: PubMed
  59. de Jong JL, Davidson AJ, Wang Y, Palis J, Opara P, Pugach E, Daley GQ, Zon LI. Interaction of retinoic acid and scl controls primitive blood development. Blood. 2010 Jul 15; 116(2):201-9.
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  60. Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010 Mar 26; 327(5973):1650-3.
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  61. Li P, Zon LI. Resolving the controversy about N-cadherin and hematopoietic stem cells. Cell Stem Cell. 2010 Mar 5; 6(3):199-202.
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  62. Paik EJ, de Jong JL, Pugach E, Opara P, Zon LI. A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis. Zebrafish. 2010 Mar; 7(1):61-8.
    View in: PubMed
  63. Zon LI, Peterson R. The new age of chemical screening in zebrafish. Zebrafish. 2010 Mar; 7(1):1.
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  64. Bowman TV, Zon LI. Swimming into the future of drug discovery: in vivo chemical screens in zebrafish. ACS Chem Biol. 2010 Feb 19; 5(2):159-61.
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  65. Smith AC, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, Storer NY, de Jong JL, Chen AT, Zhou Y, Revskoy S, Zon LI, Langenau DM. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 22; 115(16):3296-303.
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  66. Detrich HW, Westerfield M, Zon LI. The zebrafish: cellular and developmental biology, part A. Preface. Methods Cell Biol. 2010; 100:xiii.
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  67. Uong A, Zon LI. Melanocytes in development and cancer. J Cell Physiol. 2010 Jan; 222(1):38-41.
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  68. Trompouki E, Zon LI. Small molecule screen in zebrafish and HSC expansion. Methods Mol Biol. 2010; 636:301-16.
    View in: PubMed
  69. Paik EJ, Zon LI. Hematopoietic development in the zebrafish. Int J Dev Biol. 2010; 54(6-7):1127-37.
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  70. Tournoij E, Weber GJ, Akkerman JW, de Groot PG, Zon LI, Moll FL, Schulte-Merker S. Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation. J Thromb Haemost. 2010 Mar; 8(3):588-95.
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  71. Pugach EK, Li P, White R, Zon L. Retro-orbital injection in adult zebrafish. J Vis Exp. 2009; (34).
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  72. Taylor AM, Zon LI. Zebrafish tumor assays: the state of transplantation. Zebrafish. 2009 Dec; 6(4):339-46.
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  73. Dovey M, White RM, Zon LI. Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Zebrafish. 2009 Dec; 6(4):397-404.
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  74. Kaufman CK, White RM, Zon L. Chemical genetic screening in the zebrafish embryo. Nat Protoc. 2009; 4(10):1422-32.
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  75. Chen AT, Zon LI. Zebrafish blood stem cells. J Cell Biochem. 2009 Sep 1; 108(1):35-42.
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  76. North TE, Goessling W, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. Hematopoietic stem cell development is dependent on blood flow. Cell. 2009 May 15; 137(4):736-48.
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  77. Stachura DL, Reyes JR, Bartunek P, Paw BH, Zon LI, Traver D. Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood. 2009 Jul 9; 114(2):279-89.
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  78. Dovey M, Patton EE, Bowman T, North T, Goessling W, Zhou Y, Zon LI. Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Mol Cell Biol. 2009 Jul; 29(13):3746-53.
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  79. Burns CE, Galloway JL, Smith AC, Keefe MD, Cashman TJ, Paik EJ, Mayhall EA, Amsterdam AH, Zon LI. A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 2009 Jun 4; 113(23):5776-82.
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  80. Goessling W, North TE, Loewer S, Lord AM, Lee S, Stoick-Cooper CL, Weidinger G, Puder M, Daley GQ, Moon RT, Zon LI. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009 Mar 20; 136(6):1136-47.
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  81. Freeman JL, Ceol C, Feng H, Langenau DM, Belair C, Stern HM, Song A, Paw BH, Look AT, Zhou Y, Zon LI, Lee C. Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer. 2009 Feb; 48(2):155-70.
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  82. Dovey MC, Zon LI. Defining cancer stem cells by xenotransplantation in zebrafish. Methods Mol Biol. 2009; 568:1-5.
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  83. Novoa B, Bowman TV, Zon L, Figueras A. LPS response and tolerance in the zebrafish (Danio rerio). Fish Shellfish Immunol. 2009 Feb; 26(2):326-31.
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  84. Ceol CJ, Houvras Y, White RM, Zon LI. Melanoma biology and the promise of zebrafish. Zebrafish. 2008 Dec; 5(4):247-55.
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  85. Zon LI, Le X. Potential of zebrafish for anticancer drug screening. Expert Opin Drug Discov. 2008 Dec; 3(12):1451-60.
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  86. Sessa AK, White R, Houvras Y, Burke C, Pugach E, Baker B, Gilbert R, Thomas Look A, Zon LI. The effect of a depth gradient on the mating behavior, oviposition site preference, and embryo production in the zebrafish, Danio rerio. Zebrafish. 2008 Dec; 5(4):335-9.
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  87. Fraenkel PG, Gibert Y, Holzheimer JL, Lattanzi VJ, Burnett SF, Dooley KA, Wingert RA, Zon LI. Transferrin-a modulates hepcidin expression in zebrafish embryos. Blood. 2009 Mar 19; 113(12):2843-50.
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  88. Huang HT, Zon LI. Regulation of stem cells in the zebra fish hematopoietic system. Cold Spring Harb Symp Quant Biol. 2008; 73:111-8.
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  89. de Jong-Curtain TA, Parslow AC, Trotter AJ, Hall NE, Verkade H, Tabone T, Christie EL, Crowhurst MO, Layton JE, Shepherd IT, Nixon SJ, Parton RG, Zon LI, Stainier DY, Lieschke GJ, Heath JK. Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. Gastroenterology. 2009 Mar; 136(3):902-11.
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  90. Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey RD, Bayliss PE, Imai Y, Burns CE, Masutomi K, Gagos S, Zon LI, Roberts TM, Kishi S. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 2008; 3(10):e3364.
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  91. Wang L, Sewell WF, Kim SD, Shin JT, MacRae CA, Zon LI, Seidman JG, Seidman CE. Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish. Development. 2008 Oct; 135(20):3425-34.
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  92. White RM, Zon LI. Melanocytes in development, regeneration, and cancer. Cell Stem Cell. 2008 Sep 11; 3(3):242-52.
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  93. Trede NS, Ota T, Kawasaki H, Paw BH, Katz T, Demarest B, Hutchinson S, Zhou Y, Hersey C, Zapata A, Amemiya CT, Zon LI. Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen. Dev Dyn. 2008 Sep; 237(9):2575-84.
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  94. Flores MV, Hall CJ, Davidson AJ, Singh PP, Mahagaonkar AA, Zon LI, Crosier KE, Crosier PS. Intestinal differentiation in zebrafish requires Cdx1b, a functional equivalent of mammalian Cdx2. Gastroenterology. 2008 Nov; 135(5):1665-75.
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  95. Upadhyay G, Goessling W, North TE, Xavier R, Zon LI, Yajnik V. Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling. Oncogene. 2008 Oct 2; 27(44):5845-55.
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  96. Dooley KA, Fraenkel PG, Langer NB, Schmid B, Davidson AJ, Weber G, Chiang K, Foott H, Dwyer C, Wingert RA, Zhou Y, Paw BH, Zon LI. montalcino, A zebrafish model for variegate porphyria. Exp Hematol. 2008 Sep; 36(9):1132-42.
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  97. Zon LI. Self-renewal and differentiation at Cell Stem Cell. Cell Stem Cell. 2008 Jun 5; 2(6):510.
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  98. Bussmann J, Lawson N, Zon L, Schulte-Merker S. Zebrafish VEGF receptors: a guideline to nomenclature. PLoS Genet. 2008 May; 4(5):e1000064.
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  99. Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol. 2008 Aug 1; 320(1):161-74.
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  100. Zon LI. Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature. 2008 May 15; 453(7193):306-13.
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  101. Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI. Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene. 2008 Jul 10; 27(30):4242-8.
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  102. Deutsch EW, Ball CA, Berman JJ, Bova GS, Brazma A, Bumgarner RE, Campbell D, Causton HC, Christiansen JH, Daian F, Dauga D, Davidson DR, Gimenez G, Goo YA, Grimmond S, Henrich T, Herrmann BG, Johnson MH, Korb M, Mills JC, Oudes AJ, Parkinson HE, Pascal LE, Pollet N, Quackenbush J, Ramialison M, Ringwald M, Salgado D, Sansone SA, Sherlock G, Stoeckert CJ, Swedlow J, Taylor RC, Walashek L, Warford A, Wilkinson DG, Zhou Y, Zon LI, Liu AY, True LD. Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol. 2008 Mar; 26(3):305-12.
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  103. Orkin SH, Zon LI. SnapShot: hematopoiesis. Cell. 2008 Feb 22; 132(4):712.
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  104. Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008 Feb 22; 132(4):631-44.
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  105. White RM, Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, Bourque C, Dovey M, Goessling W, Burns CE, Zon LI. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell. 2008 Feb 7; 2(2):183-9.
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  106. Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LI. Combinatorial regulation of novel erythroid gene expression in zebrafish. Exp Hematol. 2008 Apr; 36(4):424-32.
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  107. Lengerke C, Schmitt S, Bowman TV, Jang IH, Maouche-Chretien L, McKinney-Freeman S, Davidson AJ, Hammerschmidt M, Rentzsch F, Green JB, Zon LI, Daley GQ. BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell. 2008 Jan 10; 2(1):72-82.
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  108. Ceol CJ, Pellman D, Zon LI. APC and colon cancer: two hits for one. Nat Med. 2007 Nov; 13(11):1286-7.
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  109. Burket CT, Montgomery JE, Thummel R, Kassen SC, LaFave MC, Langenau DM, Zon LI, Hyde DR. Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters. Transgenic Res. 2008 Apr; 17(2):265-79.
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  110. Lord AM, North TE, Zon LI. Prostaglandin E2: making more of your marrow. Cell Cycle. 2007 Dec 15; 6(24):3054-7.
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  111. Lensch MW, Schlaeger TM, Zon LI, Daley GQ. Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell. 2007 Sep 13; 1(3):253-8.
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  112. Bahary N, Goishi K, Stuckenholz C, Weber G, Leblanc J, Schafer CA, Berman SS, Klagsbrun M, Zon LI. Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood. 2007 Nov 15; 110(10):3627-36.
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  113. Freeman JL, Adeniyi A, Banerjee R, Dallaire S, Maguire SF, Chi J, Ng BL, Zepeda C, Scott CE, Humphray S, Rogers J, Zhou Y, Zon LI, Carter NP, Yang F, Lee C. Definition of the zebrafish genome using flow cytometry and cytogenetic mapping. BMC Genomics. 2007; 8:195.
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  114. Steffen LS, Guyon JR, Vogel ED, Howell MH, Zhou Y, Weber GJ, Zon LI, Kunkel LM. The zebrafish runzel muscular dystrophy is linked to the titin gene. Dev Biol. 2007 Sep 15; 309(2):180-92.
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  115. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 Jun 21; 447(7147):1007-11.
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  116. Paffett-Lugassy N, Hsia N, Fraenkel PG, Paw B, Leshinsky I, Barut B, Bahary N, Caro J, Handin R, Zon LI. Functional conservation of erythropoietin signaling in zebrafish. Blood. 2007 Oct 1; 110(7):2718-26.
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  117. Pfaff KL, Straub CT, Chiang K, Bear DM, Zhou Y, Zon LI. The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization. Mol Cell Biol. 2007 Aug; 27(16):5887-97.
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  118. Goessling W, North TE, Zon LI. Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors. Nat Methods. 2007 Jul; 4(7):551-3.
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  119. Goessling W, North TE, Zon LI. New waves of discovery: modeling cancer in zebrafish. J Clin Oncol. 2007 Jun 10; 25(17):2473-9.
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  120. Zon LI. Cell stem cell. Cell Stem Cell. 2007 Jun 7; 1(1):7.
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  121. Le X, Langenau DM, Keefe MD, Kutok JL, Neuberg DS, Zon LI. Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9410-5.
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  122. Langenau DM, Keefe MD, Storer NY, Guyon JR, Kutok JL, Le X, Goessling W, Neuberg DS, Kunkel LM, Zon LI. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev. 2007 Jun 1; 21(11):1382-95.
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  123. Trede NS, Medenbach J, Damianov A, Hung LH, Weber GJ, Paw BH, Zhou Y, Hersey C, Zapata A, Keefe M, Barut BA, Stuart AB, Katz T, Amemiya CT, Zon LI, Bindereif A. Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6608-13.
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  124. Steffen LS, Guyon JR, Vogel ED, Beltre R, Pusack TJ, Zhou Y, Zon LI, Kunkel LM. Zebrafish orthologs of human muscular dystrophy genes. BMC Genomics. 2007; 8:79.
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  125. Peng CY, Yajima H, Burns CE, Zon LI, Sisodia SS, Pfaff SL, Sharma K. Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron. 2007 Mar 15; 53(6):813-27.
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  126. LeBlanc J, Bowman TV, Zon L. Transplantation of whole kidney marrow in adult zebrafish. J Vis Exp. 2007; (2):159.
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  127. Hultman KA, Bahary N, Zon LI, Johnson SL. Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a. PLoS Genet. 2007 Jan 26; 3(1):e17.
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  128. Shepard JL, Amatruda JF, Finkelstein D, Ziai J, Finley KR, Stern HM, Chiang K, Hersey C, Barut B, Freeman JL, Lee C, Glickman JN, Kutok JL, Aster JC, Zon LI. A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes Dev. 2007 Jan 1; 21(1):55-9.
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  129. Burns CE, Zon LI. Homing sweet homing: odyssey of hematopoietic stem cells. Immunity. 2006 Dec; 25(6):859-62.
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  130. Bansal D, Scholl C, Fröhling S, McDowell E, Lee BH, Döhner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci U S A. 2006 Nov 7; 103(45):16924-9.
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  131. Murphey RD, Stern HM, Straub CT, Zon LI. A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des. 2006 Oct; 68(4):213-9.
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  132. Hu G, Tang J, Zhang B, Lin Y, Hanai J, Galloway J, Bedell V, Bahary N, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP. A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. J Cell Sci. 2006 Oct 1; 119(Pt 19):4117-26.
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  133. Murphey RD, Zon LI. Small molecule screening in the zebrafish. Methods. 2006 Jul; 39(3):255-61.
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  134. Goishi K, Shimizu A, Najarro G, Watanabe S, Rogers R, Zon LI, Klagsbrun M. AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens. Development. 2006 Jul; 133(13):2585-93.
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  135. Gupta S, Zhu H, Zon LI, Evans T. BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development. 2006 Jun; 133(11):2177-87.
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  136. Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE, Gwynn B, Lambert AJ, Wingert RA, Traver D, Trede NS, Barut BA, Zhou Y, Minet E, Donovan A, Brownlie A, Balzan R, Weiss MJ, Peters LL, Kaplan J, Zon LI, Paw BH. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006 Mar 2; 440(7080):96-100.
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  137. DiBiase A, Harte RA, Zhou Y, Zon L, Kent WJ. Piloting the zebrafish genome browser. Dev Dyn. 2006 Mar; 235(3):747-53.
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  138. Davidson AJ, Zon LI. The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis. Dev Biol. 2006 Apr 15; 292(2):506-18.
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  139. Zon LI. Derivation of adult stem cells during embryogenesis. Harvey Lect. 2006-2007; 102:117-32.
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  140. Protas ME, Hersey C, Kochanek D, Zhou Y, Wilkens H, Jeffery WR, Zon LI, Borowsky R, Tabin CJ. Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. Nat Genet. 2006 Jan; 38(1):107-11.
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  141. Stern HM, Murphey RD, Shepard JL, Amatruda JF, Straub CT, Pfaff KL, Weber G, Tallarico JA, King RW, Zon LI. Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol. 2005 Dec; 1(7):366-70.
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  142. Gardiner MR, Daggett DF, Zon LI, Perkins AC. Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching. Dev Dyn. 2005 Dec; 234(4):992-6.
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  143. Tang J, Hu G, Hanai J, Yadlapalli G, Lin Y, Zhang B, Galloway J, Bahary N, Sinha S, Thisse B, Thisse C, Jin JP, Zon LI, Sukhatme VP. A critical role for calponin 2 in vascular development. J Biol Chem. 2006 Mar 10; 281(10):6664-72.
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  144. MacDonald BA, Sund M, Grant MA, Pfaff KL, Holthaus K, Zon LI, Kalluri R. Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome. Blood. 2006 Mar 1; 107(5):1908-15.
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  145. Burns CE, Traver D, Mayhall E, Shepard JL, Zon LI. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 2005 Oct 1; 19(19):2331-42.
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  146. Shepard JL, Amatruda JF, Stern HM, Subramanian A, Finkelstein D, Ziai J, Finley KR, Pfaff KL, Hersey C, Zhou Y, Barut B, Freedman M, Lee C, Spitsbergen J, Neuberg D, Weber G, Golub TR, Glickman JN, Kutok JL, Aster JC, Zon LI. A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13194-9.
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  147. Hsia N, Zon LI. Transcriptional regulation of hematopoietic stem cell development in zebrafish. Exp Hematol. 2005 Sep; 33(9):1007-14.
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  148. Wingert RA, Galloway JL, Barut B, Foott H, Fraenkel P, Axe JL, Weber GJ, Dooley K, Davidson AJ, Schmid B, Schmidt B, Paw BH, Shaw GC, Kingsley P, Palis J, Schubert H, Chen O, Kaplan J, Zon LI. Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature. 2005 Aug 18; 436(7053):1035-39.
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  149. Lin HF, Traver D, Zhu H, Dooley K, Paw BH, Zon LI, Handin RI. Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood. 2005 Dec 1; 106(12):3803-10.
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  150. Shmukler BE, Kurschat CE, Ackermann GE, Jiang L, Zhou Y, Barut B, Stuart-Tilley AK, Zhao J, Zon LI, Drummond IA, Vandorpe DH, Paw BH, Alper SL. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F835-49.
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  151. Zhu H, Traver D, Davidson AJ, Dibiase A, Thisse C, Thisse B, Nimer S, Zon LI. Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish. Dev Biol. 2005 May 15; 281(2):256-69.
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  152. Fraenkel PG, Traver D, Donovan A, Zahrieh D, Zon LI. Ferroportin1 is required for normal iron cycling in zebrafish. J Clin Invest. 2005 Jun; 115(6):1532-41.
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  153. Akashi K, Traver D, Zon LI. The complex cartography of stem cell commitment. Cell. 2005 Apr 22; 121(2):160-2.
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  154. Weber GJ, Choe SE, Dooley KA, Paffett-Lugassy NN, Zhou Y, Zon LI. Mutant-specific gene programs in the zebrafish. Blood. 2005 Jul 15; 106(2):521-30.
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  155. Langenau DM, Zon LI. The zebrafish: a new model of T-cell and thymic development. Nat Rev Immunol. 2005 Apr; 5(4):307-17.
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  156. Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005 Mar; 1(3):191-200.
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  157. Schönberger J, Wang L, Shin JT, Kim SD, Depreux FF, Zhu H, Zon L, Pizard A, Kim JB, Macrae CA, Mungall AJ, Seidman JG, Seidman CE. Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Nat Genet. 2005 Apr; 37(4):418-22.
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  158. Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol. 2005 Feb 8; 15(3):249-54.
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  159. Dooley KA, Davidson AJ, Zon LI. Zebrafish scl functions independently in hematopoietic and endothelial development. Dev Biol. 2005 Jan 15; 277(2):522-36.
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  160. Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, Fletcher CD, Morris JP, Liu TX, Schulte-Merker S, Kanki JP, Plasterk R, Zon LI, Look AT. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):407-12.
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  161. Zon LI, Peterson RT. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005 Jan; 4(1):35-44.
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  162. Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LI. Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell. 2005 Jan; 8(1):109-16.
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  163. Paffett-Lugassy NN, Zon LI. Analysis of hematopoietic development in the zebrafish. Methods Mol Med. 2005; 105:171-98.
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  164. Patton EE, Zon LI. Taking human cancer genes to the fish: a transgenic model of melanoma in zebrafish. Zebrafish. 2005; 1(4):363-8.
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  165. de Jong JL, Zon LI. Use of the zebrafish system to study primitive and definitive hematopoiesis. Annu Rev Genet. 2005; 39:481-501.
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  166. Wingert RA, Brownlie A, Galloway JL, Dooley K, Fraenkel P, Axe JL, Davidson AJ, Barut B, Noriega L, Sheng X, Zhou Y, Zon LI. The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1. Development. 2004 Dec; 131(24):6225-35.
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  167. Mayhall EA, Paffett-Lugassy N, Zon LI. The clinical potential of stem cells. Curr Opin Cell Biol. 2004 Dec; 16(6):713-20.
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  168. Ernst P, Mabon M, Davidson AJ, Zon LI, Korsmeyer SJ. An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol. 2004 Nov 23; 14(22):2063-9.
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  169. Song HD, Sun XJ, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y, Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT, Chen Z. Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16240-5.
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  170. Davidson AJ, Zon LI. The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene. 2004 Sep 20; 23(43):7233-46.
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  171. Gong HY, Lin CJ, Chen MH, Hu MC, Lin GH, Zhou Y, Zon LI, Wu JL. Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish. Gene. 2004 Aug 18; 338(1):35-46.
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  172. Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004 Aug; 2(8):E237.
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  173. Bovenkamp DE, Goishi K, Bahary N, Davidson AJ, Zhou Y, Becker T, Becker CG, Zon LI, Klagsbrun M. Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish. Gene Expr Patterns. 2004 Jul; 4(4):361-70.
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  174. Zon LI, Zoloth L, Kadereit S. Taking the stem cell debate to the public. PLoS Biol. 2004 Jun; 2(6):e188.
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  175. Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, Kutok JL, Look AT, Zon LI. Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood. 2004 Sep 1; 104(5):1298-305.
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  176. Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7369-74.
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  177. Trede NS, Langenau DM, Traver D, Look AT, Zon LI. The use of zebrafish to understand immunity. Immunity. 2004 Apr; 20(4):367-79.
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  178. Hsu K, Traver D, Kutok JL, Hagen A, Liu TX, Paw BH, Rhodes J, Berman JN, Zon LI, Kanki JP, Look AT. The pu.1 promoter drives myeloid gene expression in zebrafish. Blood. 2004 Sep 1; 104(5):1291-7.
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  179. Zhu H, Zon LI. Use of the DsRed fluorescent reporter in zebrafish. Methods Cell Biol. 2004; 76:3-12.
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  180. Bahary N, Davidson A, Ransom D, Shepard J, Stern H, Trede N, Zhou Y, Barut B, Zon LI. The Zon laboratory guide to positional cloning in zebrafish. Methods Cell Biol. 2004; 77:305-29.
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  181. Caro J, Zon LI. Allan j. Erslev, m.d.: truly a great dane (1919-2003). Stem Cells. 2004; 22(1):121-2.
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  182. Traver D, Paw BH, Poss KD, Penberthy WT, Lin S, Zon LI. Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol. 2003 Dec; 4(12):1238-46.
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  183. North TE, Zon LI. Modeling human hematopoietic and cardiovascular diseases in zebrafish. Dev Dyn. 2003 Nov; 228(3):568-83.
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  184. Piotrowski T, Ahn DG, Schilling TF, Nair S, Ruvinsky I, Geisler R, Rauch GJ, Haffter P, Zon LI, Zhou Y, Foott H, Dawid IB, Ho RK. The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development. 2003 Oct; 130(20):5043-52.
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  185. Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003 Sep 18; 425(6955):300-6.
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  186. Ward AC, McPhee DO, Condron MM, Varma S, Cody SH, Onnebo SM, Paw BH, Zon LI, Lieschke GJ. The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood. 2003 Nov 1; 102(9):3238-40.
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  187. Goishi K, Lee P, Davidson AJ, Nishi E, Zon LI, Klagsbrun M. Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects. Mech Dev. 2003 Jul; 120(7):811-22.
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  188. Stern HM, Zon LI. Cancer genetics and drug discovery in the zebrafish. Nat Rev Cancer. 2003 Jul; 3(7):533-9.
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  189. Paw BH, Davidson AJ, Zhou Y, Li R, Pratt SJ, Lee C, Trede NS, Brownlie A, Donovan A, Liao EC, Ziai JM, Drejer AH, Guo W, Kim CH, Gwynn B, Peters LL, Chernova MN, Alper SL, Zapata A, Wickramasinghe SN, Lee MJ, Lux SE, Fritz A, Postlethwait JH, Zon LI. Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet. 2003 May; 34(1):59-64.
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  190. Guyon JR, Mosley AN, Zhou Y, O'Brien KF, Sheng X, Chiang K, Davidson AJ, Volinski JM, Zon LI, Kunkel LM. The dystrophin associated protein complex in zebrafish. Hum Mol Genet. 2003 Mar 15; 12(6):601-15.
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  191. Brownlie A, Hersey C, Oates AC, Paw BH, Falick AM, Witkowska HE, Flint J, Higgs D, Jessen J, Bahary N, Zhu H, Lin S, Zon L. Characterization of embryonic globin genes of the zebrafish. Dev Biol. 2003 Mar 1; 255(1):48-61.
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  192. Davidson AJ, Zon LI. Biomedicine. Love, honor, and protect (your liver). Science. 2003 Feb 7; 299(5608):835-7.
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  193. Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT. Myc-induced T cell leukemia in transgenic zebrafish. Science. 2003 Feb 7; 299(5608):887-90.
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  194. Galloway JL, Zon LI. Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo. Curr Top Dev Biol. 2003; 53:139-58.
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  195. Traver D, Herbomel P, Patton EE, Murphey RD, Yoder JA, Litman GW, Catic A, Amemiya CT, Zon LI, Trede NS. The zebrafish as a model organism to study development of the immune system. Adv Immunol. 2003; 81:253-330.
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  196. Burns CE, DeBlasio T, Zhou Y, Zhang J, Zon L, Nimer SD. Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Exp Hematol. 2002 Dec; 30(12):1381-9.
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  197. Burns CE, Zon LI. Portrait of a stem cell. Dev Cell. 2002 Nov; 3(5):612-3.
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  198. Zhu H, Zon LI. Use of zebrafish models for the analysis of human disease. Curr Protoc Hum Genet. 2002 Nov; Chapter 15:Unit 15.3.
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  199. Pratt SJ, Drejer A, Foott H, Barut B, Brownlie A, Postlethwait J, Kato Y, Yamamoto M, Zon LI. Isolation and characterization of zebrafish NFE2. Physiol Genomics. 2002 Oct 29; 11(2):91-8.
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  200. Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI. SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell. 2002 Oct; 10(4):843-55.
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  201. Ross S, Best JL, Zon LI, Gill G. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell. 2002 Oct; 10(4):831-42.
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  202. Shafizadeh E, Paw BH, Foott H, Liao EC, Barut BA, Cope JJ, Zon LI, Lin S. Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency. Development. 2002 Sep; 129(18):4359-70.
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  203. Langenau DM, Palomero T, Kanki JP, Ferrando AA, Zhou Y, Zon LI, Look AT. Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio). Mech Dev. 2002 Sep; 117(1-2):243-8.
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  204. Donovan A, Brownlie A, Dorschner MO, Zhou Y, Pratt SJ, Paw BH, Phillips RB, Thisse C, Thisse B, Zon LI. The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood. 2002 Dec 15; 100(13):4655-9.
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  205. Murphey RD, Zon LI. Attack of the fish clones. Nat Biotechnol. 2002 Aug; 20(8):785-6.
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  206. Lee P, Goishi K, Davidson AJ, Mannix R, Zon L, Klagsbrun M. Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16):10470-5.
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  207. Lieschke GJ, Oates AC, Paw BH, Thompson MA, Hall NE, Ward AC, Ho RK, Zon LI, Layton JE. Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev Biol. 2002 Jun 15; 246(2):274-95.
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  208. Liu TX, Zhou Y, Kanki JP, Deng M, Rhodes J, Yang HW, Sheng XM, Zon LI, Look AT. Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6136-41.
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  209. Amatruda JF, Shepard JL, Stern HM, Zon LI. Zebrafish as a cancer model system. Cancer Cell. 2002 Apr; 1(3):229-31.
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  210. Orkin SH, Zon LI. Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol. 2002 Apr; 3(4):323-8.
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  211. Traver D, Zon LI. Walking the walk: migration and other common themes in blood and vascular development. Cell. 2002 Mar 22; 108(6):731-4.
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  212. Liao EC, Trede NS, Ransom D, Zapata A, Kieran M, Zon LI. Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish. Development. 2002 Feb; 129(3):649-59.
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  213. Thisse C, Zon LI. Organogenesis--heart and blood formation from the zebrafish point of view. Science. 2002 Jan 18; 295(5554):457-62.
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  214. Lyons SE, Shue BC, Lei L, Oates AC, Zon LI, Liu PP. Molecular cloning, genetic mapping, and expression analysis of four zebrafish c/ebp genes. Gene. 2001 Dec 27; 281(1-2):43-51.
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  215. Hukriede N, Fisher D, Epstein J, Joly L, Tellis P, Zhou Y, Barbazuk B, Cox K, Fenton-Noriega L, Hersey C, Miles J, Sheng X, Song A, Waterman R, Johnson SL, Dawid IB, Chevrette M, Zon LI, McPherson J, Ekker M. The LN54 radiation hybrid map of zebrafish expressed sequences. Genome Res. 2001 Dec; 11(12):2127-32.
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  216. Patton EE, Zon LI. The art and design of genetic screens: zebrafish. Nat Rev Genet. 2001 Dec; 2(12):956-66.
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  217. Bahary N, Zon LI. Development. Endothelium--chicken soup for the endoderm. Science. 2001 Oct 19; 294(5542):530-1.
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  218. Huber TL, Perkins AC, Deconinck AE, Chan FY, Mead PE, Zon LI. neptune, a Krüppel-like transcription factor that participates in primitive erythropoiesis in Xenopus. Curr Biol. 2001 Sep 18; 11(18):1456-61.
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  219. Oates AC, Pratt SJ, Vail B. The zebrafish klf gene family. Blood. 2001 Sep 15; 98(6):1792-801.
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  220. Moretti PA, Davidson AJ, Baker E, Lilley B, Zon LI, D'Andrea RJ. Molecular cloning of a human Vent-like homeobox gene. Genomics. 2001 Aug; 76(1-3):21-9.
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  221. Bennett CM, Kanki JP, Rhodes J, Liu TX, Paw BH, Kieran MW, Langenau DM, Delahaye-Brown A, Zon LI, Fleming MD, Look AT. Myelopoiesis in the zebrafish, Danio rerio. Blood. 2001 Aug 1; 98(3):643-51.
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  222. Trede NS, Zapata A, Zon LI. Fishing for lymphoid genes. Trends Immunol. 2001 Jun; 22(6):302-7.
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  223. Mead PE, Deconinck AE, Huber TL, Orkin SH, Zon LI. Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development. 2001 Jun; 128(12):2301-8.
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  224. Hamazaki T, Iiboshi Y, Oka M, Papst PJ, Meacham AM, Zon LI, Terada N. Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett. 2001 May 18; 497(1):15-9.
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  225. Lyons SE, Shue BC, Oates AC, Zon LI, Liu PP. A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain. Blood. 2001 May 1; 97(9):2611-7.
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  226. Chayama K, Papst PJ, Garrington TP, Pratt JC, Ishizuka T, Webb S, Ganiatsas S, Zon LI, Sun W, Johnson GL, Gelfand EW. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4599-604.
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  227. Zon LI. Self-renewal versus differentiation, a job for the mighty morphogens. Nat Immunol. 2001 Feb; 2(2):142-3.
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  228. Miyoshi K, Cui Y, Riedlinger G, Robinson P, Lehoczky J, Zon L, Oka T, Dewar K, Hennighausen L. Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Genomics. 2001 Jan 15; 71(2):150-5.
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  229. Blake T, Adya N, Kim CH, Oates AC, Zon L, Chitnis A, Weinstein BM, Liu PP. Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 2000 Dec 15; 96(13):4178-84.
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  230. Liao EC, Paw BH, Peters LL, Zapata A, Pratt SJ, Do CP, Lieschke G, Zon LI. Hereditary spherocytosis in zebrafish riesling illustrates evolution of erythroid beta-spectrin structure, and function in red cell morphogenesis and membrane stability. Development. 2000 Dec; 127(23):5123-32.
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  231. LaPatra SE, Barone L, Jones GR, Zon LI. Effects of infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus infection on hematopoietic precursors of the zebrafish. Blood Cells Mol Dis. 2000 Oct; 26(5):445-52.
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  232. Jagadeeswaran P, Gregory M, Zhou Y, Zon L, Padmanabhan K, Hanumanthaiah R. Characterization of zebrafish full-length prothrombin cDNA and linkage group mapping. Blood Cells Mol Dis. 2000 Oct; 26(5):479-89.
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  233. Tsai M, Wedemeyer J, Ganiatsas S, Tam SY, Zon LI, Galli SJ. In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo. Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):9186-90.
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  234. Parichy DM, Ransom DG, Paw B, Zon LI, Johnson SL. An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development. 2000 Jul; 127(14):3031-44.
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  235. Dooley K, Zon LI. Zebrafish: a model system for the study of human disease. Curr Opin Genet Dev. 2000 Jun; 10(3):252-6.
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  236. Deconinck AE, Mead PE, Tevosian SG, Crispino JD, Katz SG, Zon LI, Orkin SH. FOG acts as a repressor of red blood cell development in Xenopus. Development. 2000 May; 127(10):2031-40.
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  237. Barut BA, Zon LI. Realizing the potential of zebrafish as a model for human disease. Physiol Genomics. 2000 Mar 13; 2(2):49-51.
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  238. Paw BH, Zon LI. Zebrafish: a genetic approach in studying hematopoiesis. Curr Opin Hematol. 2000 Mar; 7(2):79-84.
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  239. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000 Feb 17; 403(6771):776-81.
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  240. White RA, Pasztor LM, Richardson PM, Zon LI. The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. Cytogenet Cell Genet. 2000; 89(3-4):272-5.
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  241. Davidson AJ, Zon LI. Turning mesoderm into blood: the formation of hematopoietic stem cells during embryogenesis. Curr Top Dev Biol. 2000; 50:45-60.
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  242. Shepard JL, Zon LI. Developmental derivation of embryonic and adult macrophages. Curr Opin Hematol. 2000 Jan; 7(1):3-8.
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  243. Amatruda JF, Zon LI. Dissecting hematopoiesis and disease using the zebrafish. Dev Biol. 1999 Dec 1; 216(1):1-15.
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  244. Kieran MW, Katz S, Vail B, Zon LI, Mayer BJ. Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase. Oncogene. 1999 Nov 18; 18(48):6647-57.
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  245. Oates AC, Brownlie A, Pratt SJ, Irvine DV, Liao EC, Paw BH, Dorian KJ, Johnson SL, Postlethwait JH, Zon LI, Wilks AF. Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis. Blood. 1999 Oct 15; 94(8):2622-36.
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  246. Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999 Oct; 126(20):4603-15.
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  247. Hukriede NA, Joly L, Tsang M, Miles J, Tellis P, Epstein JA, Barbazuk WB, Li FN, Paw B, Postlethwait JH, Hudson TJ, Zon LI, McPherson JD, Chevrette M, Dawid IB, Johnson SL, Ekker M. Radiation hybrid mapping of the zebrafish genome. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9745-50.
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  248. Rubin DA, Hellman P, Zon LI, Lobb CJ, Bergwitz C, Jüppner H. A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones. J Biol Chem. 1999 Aug 13; 274(33):23035-42.
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  249. Oates AC, Wollberg P, Pratt SJ, Paw BH, Johnson SL, Ho RK, Postlethwait JH, Zon LI, Wilks AF. Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Dev Dyn. 1999 Aug; 215(4):352-70.
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  250. Amemiya CT, Zon LI. Generation of a zebrafish P1 artificial chromosome library. Genomics. 1999 Jun 1; 58(2):211-3.
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  251. Meriin AB, Yaglom JA, Gabai VL, Zon L, Ganiatsas S, Mosser DD, Zon L, Sherman MY. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol. 1999 Apr; 19(4):2547-55.
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  252. Zon LI. Zebrafish: a new model for human disease. Genome Res. 1999 Feb; 9(2):99-100.
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  253. Ransom DG, Zon LI. Mapping zebrafish mutations by AFLP. Methods Cell Biol. 1999; 60:195-211.
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  254. Parker LH, Zon LI, Stainier DY. Vascular and blood gene expression. Methods Cell Biol. 1999; 59:313-36.
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  255. Kane DA, Zon LI, Detrich HW. Centromeric markers in the zebrafish. Methods Cell Biol. 1999; 60:361-3.
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  256. Paw BH, Zon LI. Primary fibroblast cell culture. Methods Cell Biol. 1999; 59:39-43.
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  257. Liao EC, Zon LI. Simple sequence-length polymorphism analysis. Methods Cell Biol. 1999; 60:181-3.
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  258. Johnson SL, Zon LI. Genetic backgrounds and some standard stocks and strains used in zebrafish developmental biology and genetics. Methods Cell Biol. 1999; 60:357-9.
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  259. Amemiya CT, Zhong TP, Silverman GA, Fishman MC, Zon LI. Zebrafish YAC, BAC, and PAC genomic libraries. Methods Cell Biol. 1999; 60:235-58.
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  260. Detrich HW, Westerfield M, Zon LI. Overview of the Zebrafish system. Methods Cell Biol. 1999; 59:3-10.
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  261. Ransom DG, Zon LI. Collection, storage, and use of zebrafish sperm. Methods Cell Biol. 1999; 60:365-72.
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  262. Huber TL, Zhou Y, Mead PE, Zon LI. Cooperative effects of growth factors involved in the induction of hematopoietic mesoderm. Blood. 1998 Dec 1; 92(11):4128-37.
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  263. Brownlie A, Donovan A, Pratt SJ, Paw BH, Oates AC, Brugnara C, Witkowska HE, Sassa S, Zon LI. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet. 1998 Nov; 20(3):244-50.
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  264. Mead PE, Zhou Y, Lustig KD, Huber TL, Kirschner MW, Zon LI. Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11251-6.
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  265. Alberola-Ila J, Levin SD, Barton G, Forbush K, Zon LI, Perlmutter RM. Analysis of the role of MKK-4/Sek-1 in T cell development and apoptosis. Int Immunol. 1998 Aug; 10(8):1077-82.
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  266. Kwok C, Korn RM, Davis ME, Burt DW, Critcher R, McCarthy L, Paw BH, Zon LI, Goodfellow PN, Schmitt K. Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. Nucleic Acids Res. 1998 Aug 1; 26(15):3562-6.
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  267. Förnzler D, Her H, Knapik EW, Clark M, Lehrach H, Postlethwait JH, Zon LI, Beier DR. Gene mapping in zebrafish using single-strand conformation polymorphism analysis. Genomics. 1998 Jul 15; 51(2):216-22.
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  268. Mead PE, Kelley CM, Hahn PS, Piedad O, Zon LI. SCL specifies hematopoietic mesoderm in Xenopus embryos. Development. 1998 Jul; 125(14):2611-20.
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  269. Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA, Zon LI. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):6881-6.
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  270. Thompson MA, Ransom DG, Pratt SJ, MacLennan H, Kieran MW, Detrich HW, Vail B, Huber TL, Paw B, Brownlie AJ, Oates AC, Fritz A, Gates MA, Amores A, Bahary N, Talbot WS, Her H, Beier DR, Postlethwait JH, Zon LI. The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol. 1998 May 15; 197(2):248-69.
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  271. Trede NS, Zon LI. Development of T-cells during fish embryogenesis. Dev Comp Immunol. 1998 May-Jun; 22(3):253-63.
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  272. Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 1998 May; 8(5):625-34.
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  273. Jessen JR, Meng A, McFarlane RJ, Paw BH, Zon LI, Smith GR, Lin S. Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5121-6.
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  274. Huber TL, Zon LI. Transcriptional regulation of blood formation during Xenopus development. Semin Immunol. 1998 Apr; 10(2):103-9.
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  275. Postlethwait JH, Yan YL, Gates MA, Horne S, Amores A, Brownlie A, Donovan A, Egan ES, Force A, Gong Z, Goutel C, Fritz A, Kelsh R, Knapik E, Liao E, Paw B, Ransom D, Singer A, Thomson M, Abduljabbar TS, Yelick P, Beier D, Joly JS, Larhammar D, Rosa F, Westerfield M, Zon LI, Johnson SL, Talbot WS. Vertebrate genome evolution and the zebrafish gene map. Nat Genet. 1998 Apr; 18(4):345-9.
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  276. Mead PE, Zon LI. Molecular insights into early hematopoiesis. Curr Opin Hematol. 1998 Mar; 5(2):156-60.
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  277. Liao EC, Paw BH, Oates AC, Pratt SJ, Postlethwait JH, Zon LI. SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev. 1998 Mar 1; 12(5):621-6.
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  278. Yamaguchi Y, Zon LI, Ackerman SJ, Yamamoto M, Suda T. Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation. Blood. 1998 Jan 15; 91(2):450-7.
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  279. Bahary N, Zon LI. Use of the zebrafish (Danio rerio) to define hematopoiesis. Stem Cells. 1998; 16 Suppl 2:67-78.
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  280. Bahary N, Zon LI. Use of the zebrafish (Danio rerio) to define hematopoiesis. Stem Cells. 1998; 16(2):89-98.
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  281. Lee KH, Marden JJ, Thompson MS, MacLennan H, Kishimoto Y, Pratt SJ, Schulte-Merker S, Hammerschmidt M, Johnson SL, Postlethwaite JH, Beier DC, Zon LI. Cloning and genetic mapping of zebrafish BMP-2. Dev Genet. 1998; 23(2):97-103.
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  282. Kishimoto Y, Lee KH, Zon L, Hammerschmidt M, Schulte-Merker S. The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development. 1997 Nov; 124(22):4457-66.
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  283. Turpen JB, Kelley CM, Mead PE, Zon LI. Bipotential primitive-definitive hematopoietic progenitors in the vertebrate embryo. Immunity. 1997 Sep; 7(3):325-34.
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  284. Hirai Si, Katoh M, Terada M, Kyriakis JM, Zon LI, Rana A, Avruch J, Ohno S. MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem. 1997 Jun 13; 272(24):15167-73.
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  285. Molnár A, Theodoras AM, Zon LI, Kyriakis JM. Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK. J Biol Chem. 1997 May 16; 272(20):13229-35.
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  286. Chan FY, Robinson J, Brownlie A, Shivdasani RA, Donovan A, Brugnara C, Kim J, Lau BC, Witkowska HE, Zon LI. Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997 Jan 15; 89(2):688-700.
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  287. Lustig KD, Stukenberg PT, McGarry TJ, King RW, Cryns VL, Mead PE, Zon LI, Yuan J, Kirschner MW. Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. Methods Enzymol. 1997; 283:83-99.
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  288. Orkin SH, Zon LI. Genetics of erythropoiesis: induced mutations in mice and zebrafish. Annu Rev Genet. 1997; 31:33-60.
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  289. Watanabe G, Howe A, Lee RJ, Albanese C, Shu IW, Karnezis AN, Zon L, Kyriakis J, Rundell K, Pestell RG. Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12861-6.
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  290. Maeno M, Mead PE, Kelley C, Xu RH, Kung HF, Suzuki A, Ueno N, Zon LI. The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis. Blood. 1996 Sep 15; 88(6):1965-72.
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  291. Pestell RG, Albanese C, Watanabe G, Lee RJ, Lastowiecki P, Zon L, Ostrowski M, Jameson JL. Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways. Mol Endocrinol. 1996 Sep; 10(9):1084-94.
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  292. Kieran MW, Perkins AC, Orkin SH, Zon LI. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9126-31.
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  293. Haire RN, Ota T, Rast JP, Litman RT, Chan FY, Zon LI, Litman GW. A third Ig light chain gene isotype in Xenopus laevis consists of six distinct VL families and is related to mammalian lambda genes. J Immunol. 1996 Aug 15; 157(4):1544-50.
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  294. Rana A, Gallo K, Godowski P, Hirai S, Ohno S, Zon L, Kyriakis JM, Avruch J. The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J Biol Chem. 1996 Aug 9; 271(32):19025-8.
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  295. Mead PE, Brivanlou IH, Kelley CM, Zon LI. BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein Mix.1. Nature. 1996 Jul 25; 382(6589):357-60.
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  296. Bishop TR, Miller MW, Beall J, Zon LI, Dierks P. Genetic regulation of delta-aminolevulinate dehydratase during erythropoiesis. Nucleic Acids Res. 1996 Jul 1; 24(13):2511-8.
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  297. Sen J, Kapeller R, Fragoso R, Sen R, Zon LI, Burakoff SJ. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. J Immunol. 1996 Jun 15; 156(12):4535-8.
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  298. White RA, Hughes RT, Adkison LR, Bruns G, Zon LI. The gene encoding protein kinase SEK1 maps to mouse chromosome 11 and human chromosome 17. Genomics. 1996 Jun 15; 34(3):430-2.
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  299. Zanke BW, Boudreau K, Rubie E, Winnett E, Tibbles LA, Zon L, Kyriakis J, Liu FF, Woodgett JR. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr Biol. 1996 May 1; 6(5):606-13.
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  300. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 1996 Mar 7; 380(6569):75-9.
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  301. Woodgett JR, Kyriakis JM, Avruch J, Zon LI, Zanke B, Templeton DJ. Reconstitution of novel signalling cascades responding to cellular stresses. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):135-41; discussion 142.
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  302. Johnson NL, Gardner AM, Diener KM, Lange-Carter CA, Gleavy J, Jarpe MB, Minden A, Karin M, Zon LI, Johnson GL. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J Biol Chem. 1996 Feb 9; 271(6):3229-37.
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  303. Kieran MW, Zon LI. Stress- and mitogen-activated signal transduction in hematopoietic cells. Curr Opin Hematol. 1996 Jan; 3(1):27-34.
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  304. Kharbanda S, Pandey P, Ren R, Mayer B, Zon L, Kufe D. c-Abl activation regulates induction of the SEK1/stress-activated protein kinase pathway in the cellular response to 1-beta-D-arabinofuranosylcytosine. J Biol Chem. 1995 Dec 22; 270(51):30278-81.
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  305. Winardi R, Discher D, Kelley C, Zon L, Mays K, Mohandas N, Conboy JG. Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrin-actin binding domain of erythroid protein 4.1. Blood. 1995 Dec 1; 86(11):4315-22.
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  306. Detrich HW, Kieran MW, Chan FY, Barone LM, Yee K, Rundstadler JA, Pratt S, Ransom D, Zon LI. Intraembryonic hematopoietic cell migration during vertebrate development. Proc Natl Acad Sci U S A. 1995 Nov 7; 92(23):10713-7.
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  307. Pombo CM, Kehrl JH, Sánchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis JM. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature. 1995 Oct 26; 377(6551):750-4.
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  308. Zon LI. Developmental biology of hematopoiesis. Blood. 1995 Oct 15; 86(8):2876-91.
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  309. Stainier DY, Weinstein BM, Detrich HW, Zon LI, Fishman MC. Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development. 1995 Oct; 121(10):3141-50.
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  310. Richardson PM, Zon LI. Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Oncogene. 1995 Sep 21; 11(6):1139-48.
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  311. Hughes R, Chan FY, White RA, Zon LI. Cloning and chromosomal localization of a mouse cDNA with homology to the Saccharomyces cerevisiae gene zuotin. Genomics. 1995 Sep 20; 29(2):546-50.
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  312. Sánchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM, Zon LI. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature. 1994 Dec 22-29; 372(6508):794-8.
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  313. Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR, Templeton DJ. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature. 1994 Dec 22-29; 372(6508):798-800.
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  314. Kelley C, Yee K, Harland R, Zon LI. Ventral expression of GATA-1 and GATA-2 in the Xenopus embryo defines induction of hematopoietic mesoderm. Dev Biol. 1994 Sep; 165(1):193-205.
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  315. Yashar BM, Kelley C, Yee K, Errede B, Zon LI. Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. Mol Cell Biol. 1993 Sep; 13(9):5738-48.
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  316. Yee K, Bishop TR, Mather C, Zon LI. Isolation of a novel receptor tyrosine kinase cDNA expressed by developing erythroid progenitors. Blood. 1993 Aug 15; 82(4):1335-43.
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  317. Kelley C, Blumberg H, Zon LI, Evans T. GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Development. 1993 Jul; 118(3):817-27.
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  318. Zon LI, Yamaguchi Y, Yee K, Albee EA, Kimura A, Bennett JC, Orkin SH, Ackerman SJ. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood. 1993 Jun 15; 81(12):3234-41.
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  319. Barut BA, Zon LI, Cochran MK, Paul SR, Chauhan D, Mohrbacher A, Fingeroth J, Anderson KC. Role of interleukin 6 in the growth of myeloma-derived cell lines. Leuk Res. 1992 Oct; 16(10):951-9.
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  320. Sposi NM, Zon LI, Carè A, Valtieri M, Testa U, Gabbianelli M, Mariani G, Bottero L, Mather C, Orkin SH, et al. Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6353-7.
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  321. Zon LI, Moreau JF, Koo JW, Mathey-Prevot B, D'Andrea AD. The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein. Mol Cell Biol. 1992 Jul; 12(7):2949-57.
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  322. Zon LI, Orkin SH. Sequence of the human GATA-1 promoter. Nucleic Acids Res. 1992 Apr 11; 20(7):1812.
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  323. Hromas R, Zon L, Friedman AD. Hematopoietic transcription regulators and the origins of leukemia. Crit Rev Oncol Hematol. 1992 Mar; 12(2):167-90.
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  324. Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5; 266(34):22948-53.
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  325. Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10638-41.
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  326. Zon LI, Mather C, Burgess S, Bolce ME, Harland RM, Orkin SH. Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10642-6.
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  327. D'Andrea AD, Yoshimura A, Youssoufian H, Zon LI, Koo JW, Lodish HF. The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol Cell Biol. 1991 Apr; 11(4):1980-7.
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  328. Mignotte V, Navarro S, Eleouet JF, Zon LI, Romeo PH. The extinction of erythroid genes after tetradecanoylphorbol acetate treatment of erythroleukemic cells correlates with down-regulation of the tissue-specific factors NF-E1 and NF-E2. J Biol Chem. 1990 Dec 25; 265(36):22090-2.
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  329. D'Andrea AD, Zon LI. Erythropoietin receptor. Subunit structure and activation. J Clin Invest. 1990 Sep; 86(3):681-7.
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  330. Youssoufian H, Zon LI, Orkin SH, D'Andrea AD, Lodish HF. Structure and transcription of the mouse erythropoietin receptor gene. Mol Cell Biol. 1990 Jul; 10(7):3675-82.
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  331. Martin DI, Zon LI, Mutter G, Orkin SH. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature. 1990 Mar 29; 344(6265):444-7.
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  332. Zon LI, Tsai SF, Burgess S, Matsudaira P, Bruns GA, Orkin SH. The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):668-72.
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  333. D'Andrea AD, Fasman GD, Zon LI, Li JP, Lodish HF. Structure of the erythropoietin receptor in stable fibroblast transfectants. Prog Clin Biol Res. 1990; 352:153-9.
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  334. Scadden DT, Zon LI, Groopman JE. Pathophysiology and management of HIV-associated hematologic disorders. Blood. 1989 Oct; 74(5):1455-63.
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  335. Zon LI, Dorfman DM, Orkin SH. The polymerase chain reaction colony miniprep. Biotechniques. 1989 Jul-Aug; 7(7):696-8.
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  336. Tsai SF, Martin DI, Zon LI, D'Andrea AD, Wong GG, Orkin SH. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989 Jun 8; 339(6224):446-51.
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  337. Dorfman DM, Zon LI, Orkin SH. Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR). Biotechniques. 1989 Jun; 7(6):568, 570.
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  338. Zon LI, Johns WD, Stomper PC, Kaplan WD, Connolly JL, Morris JH, Harris JR, Henderson IC, Skarin AT. Breast carcinoma metastatic to a meningioma. Case report and review of the literature. Arch Intern Med. 1989 Apr; 149(4):959-62.
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  339. Zon LI, Groopman JE. Hematologic manifestations of the human immune deficiency virus (HIV). Semin Hematol. 1988 Jul; 25(3):208-18.
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  340. Zon LI, Arkin C, Groopman JE. Haematologic manifestations of the human immune deficiency virus (HIV). Br J Haematol. 1987 Jun; 66(2):251-6.
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  341. Canoso RT, Zon LI, Groopman JE. Anticardiolipin antibodies associated with HTLV-III infection. Br J Haematol. 1987 Apr; 65(4):495-8.
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  342. Donahue RE, Johnson MM, Zon LI, Clark SC, Groopman JE. Suppression of in vitro haematopoiesis following human immunodeficiency virus infection. Nature. 1987 Mar 12-18; 326(6109):200-3.
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  343. Clairmont GJ, Zon LI, Groopman JE. Hemophilus parainfluenzae prostatitis in a homosexual man with chronic lymphadenopathy syndrome and HTLV-III infection. Am J Med. 1987 Jan; 82(1):175-8.
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  344. Zon LI, Archibald DW, McLane MF, Essex M, Hepner MJ, Groopman JE. IgA deficiency and salivary transmission of human immunodeficiency virus. Lancet. 1986 Nov 1; 2(8514):1039-40.
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  345. Archibald DW, Zon LI, Groopman JE, Allan JS, McLane MF, Essex ME. Salivary antibodies as a means of detecting human T cell lymphotropic virus type III/lymphadenopathy-associated virus infection. J Clin Microbiol. 1986 Nov; 24(5):873-5.
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  346. Archibald DW, Zon L, Groopman JE, McLane MF, Essex M. Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS. Blood. 1986 Mar; 67(3):831-4.
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  347. Caro J, Zon LI, Silver R, Miller O, Erslev AJ. Erythropoietin in liver tissue extracts and in liver perfusates from hypoxic rats. Am J Physiol. 1983 May; 244(5):E431-4.
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