Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Samir Mukund Parikh, M.D.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Research North 280C
330 Brookline Ave
Boston MA 02215
Phone617/667-5813
Fax617/667-2646

 Mentoring 
 current student opportunities
Available: 07/18/12, Expires: 07/17/14

The host immune response to severe infections has evolved in concert with exposure to microbial pathogens. The result is a multi-tiered, highly coordinated, redundant inflammatory and immune attack against invasive organisms. In sepsis, the host response is severe enough to injure its own organs, often culminating in death from shock and multi-organ failure. Yet, efforts to therapeutically manipulate the immune response in sepsis have uniformly failed. Our laboratory studies another approach to sepsis--namely, limiting the bystander damage. In particular, we study molecular mechanisms in the vascular endothelium that prevent the profound leakiness of blood vessels that contributes to lung injury, hypoxia, and shock in sepsis. Applying a combination of human, animal, and cellular studies, we have found across-the-board evidence implicating one such pathway as a critical mediator of vascular leak and inflammation in sepsis, the Angiopoietin-Tie2 axis. We have proposed that Angiopoietin-2 may be an early prognostic biomarker of adverse outcomes in severe sepsis, and we have found that novel methods of stimulating Tie-2 prevent leakage and death of septic animals. Defined student role: The interested student will perform laboratory-based research to study molecular mechanisms of Angiopoietin action in cellular models of sepsis and animal tissues. The project will utilize cloning, eukaryotic cell culture, PCR, Western analysis, confocal microscopy, and/or ELISA. This setting will provide an opportunity to perform translational research on a medically important topic, the results of which may have a lasting impact on the field.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Parikh SM. Therapeutic targeting of the mitochondrial dysfunction in septic acute kidney injury. Curr Opin Crit Care. 2013 Dec; 19(6):554-9.
    View in: PubMed
  2. Karumanchi SA, Parikh SM. Moving forward in sepsis research. Am J Respir Crit Care Med. 2013 Nov 15; 188(10):1264-5.
    View in: PubMed
  3. Maski MR, Parikh SM. The vasculature in diabetic nephropathy: all tied up? J Am Soc Nephrol. 2014 Jan; 25(1):1-3.
    View in: PubMed
  4. Hebert LA, Parikh S, Prosek J, Nadasdy T, Rovin BH. Differential diagnosis of glomerular disease: a systematic and inclusive approach. Am J Nephrol. 2013; 38(3):253-66.
    View in: PubMed
  5. Parikh SM. Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence. 2013 Aug 15; 4(6):517-24.
    View in: PubMed
  6. Nigwekar SU, Bhan I, Turchin A, Skentzos SC, Hajhosseiny R, Steele D, Nazarian RM, Wenger J, Parikh S, Karumanchi A, Thadhani R. Statin use and calcific uremic arteriolopathy: a matched case-control study. Am J Nephrol. 2013; 37:325-32.
    View in: PubMed
  7. Berg AH, Drechsler C, Wenger J, Buccafusca R, Hod T, Kalim S, Ramma W, Parikh SM, Steen H, Friedman DJ, Danziger J, Wanner C, Thadhani R, Karumanchi SA. Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure. Sci Transl Med. 2013 Mar 6; 5(175):175ra29.
    View in: PubMed
  8. David S, Kümpers P, van Slyke P, Parikh SM. Mending leaky blood vessels: the angiopoietin-tie2 pathway in sepsis. J Pharmacol Exp Ther. 2013 Apr; 345(1):2-6.
    View in: PubMed
  9. Singh N, McNeely J, Parikh S, Bhinder A, Rovin BH, Shidham G. Kidney complications of hematopoietic stem cell transplantation. Am J Kidney Dis. 2013 May; 61(5):809-21.
    View in: PubMed
  10. Singh N, Parikh S, Bhatt U, Vonvisger J, Nori U, Hasan A, Samavedi S, Andreoni K, Henry M, Pelletier R, Rajab A, Elkhammas E, Pesavento T. Cardiac stress test as a risk-stratification tool for posttransplant cardiac outcomes in diabetic kidney transplant recipients. Transplantation. 2012 Dec 27; 94(12):1224-9.
    View in: PubMed
  11. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med. 2012 Nov; 40(11):3034-41.
    View in: PubMed
  12. Clajus C, Lukasz A, David S, Hertel B, Lichtinghagen R, Parikh SM, Simon A, Ismail I, Haller H, Kümpers P. Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass. Cytokine. 2012 Nov; 60(2):352-9.
    View in: PubMed
  13. Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM. Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):10024-9.
    View in: PubMed
  14. Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem. 2012 Jul; 60(7):521-9.
    View in: PubMed
  15. van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K. Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock. 2012 Apr; 37(4):392-8.
    View in: PubMed
  16. Xie Z, Ghosh CC, Patel R, Iwaki S, Gaskins D, Nelson C, Jones N, Greipp PR, Parikh SM, Druey KM. Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood. 2012 May 3; 119(18):4321-32.
    View in: PubMed
  17. Rajakumar A, Cerdeira AS, Rana S, Zsengeller Z, Edmunds L, Jeyabalan A, Hubel CA, Stillman IE, Parikh SM, Karumanchi SA. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension. 2012 Feb; 59(2):256-64.
    View in: PubMed
  18. Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med. 2012 Jan 15; 52(2):497-506.
    View in: PubMed
  19. David S, Ghosh CC, Mukherjee A, Parikh SM. Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2643-52.
    View in: PubMed
  20. Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N. The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care. 2011; 15(5):R261.
    View in: PubMed
  21. Parikh SM. Circulating mediators of focal segmental glomerulosclerosis: soluble urokinase plasminogen activator receptor in context. Am J Kidney Dis. 2012 Mar; 59(3):336-9.
    View in: PubMed
  22. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011 Oct; 121(10):4003-14.
    View in: PubMed
  23. David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM. Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L851-62.
    View in: PubMed
  24. Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care. 2010; 14(5):R182.
    View in: PubMed
  25. Parikh SM, Pollak MR. VEGF receptors and glomerular function. J Am Soc Nephrol. 2010 Oct; 21(10):1599-600.
    View in: PubMed
  26. Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010 Jul 1; 185(1):517-24.
    View in: PubMed
  27. Yuan HT, Khankin EV, Karumanchi SA, Parikh SM. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol. 2009 Apr; 29(8):2011-22.
    View in: PubMed
  28. Parikh SM, Karumanchi SA. Putting pressure on pre-eclampsia. Nat Med. 2008 Aug; 14(8):810-2.
    View in: PubMed
  29. Gallagher DC, Parikh SM, Balonov K, Miller A, Gautam S, Talmor D, Sukhatme VP. Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome. Shock. 2008 Jun; 29(6):656-61.
    View in: PubMed
  30. Cohen RA, Parikh SM. Images in clinical medicine. Calcinosis associated with renal failure. N Engl J Med. 2007 Dec 20; 357(25):2615.
    View in: PubMed
  31. Giuliano JS, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS. Admission angiopoietin levels in children with septic shock. Shock. 2007 Dec; 28(6):650-654.
    View in: PubMed
  32. Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007 Aug 17; 282(33):23910-8.
    View in: PubMed
  33. Gallagher DC, Bhatt RS, Parikh SM, Patel P, Seery V, McDermott DF, Atkins MB, Sukhatme VP. Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak. Clin Cancer Res. 2007 Apr 1; 13(7):2115-20.
    View in: PubMed
  34. Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 2006 Mar; 3(3):e46.
    View in: PubMed
  35. Del Rio M, Imam A, DeLeon M, Gomez G, Mishra J, Ma Q, Parikh S, Devarajan P. The death domain of kidney ankyrin interacts with Fas and promotes Fas-mediated cell death in renal epithelia. J Am Soc Nephrol. 2004 Jan; 15(1):41-51.
    View in: PubMed
  36. Parikh SM, Diedrich A, Biaggioni I, Robertson D. The nature of the autonomic dysfunction in multiple system atrophy. J Neurol Sci. 2002 Aug 15; 200(1-2):1-10.
    View in: PubMed
  37. Reddy VS, Parikh SM, Drinkwater DC, Lo A, Rauth TP, Moleski RM, Chang PA. Morbidity after procurement of radial arteries in diabetic patients and the elderly undergoing coronary revascularization. Ann Thorac Surg. 2002 Mar; 73(3):803-7; discussion 807-8.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Parikh's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_