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Cornelis Terhorst, PH.D.

TitleProfessor of Medicine (Pediatrics)
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Ctr
Cls 938
3 Blackfan Circle
Boston MA 02115
Phone6177354130

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Okamoto S, Ji H, Howie D, Clarke K, Gullo C, Manning S, Coyle AJ, Terhorst C. Expression of the SH2D1A gene is regulated by a combination of transcriptional and post-transcriptional mechanisms. Eur J Immunol. 2004 Nov; 34(11):3176-86.
    View in: PubMed
  2. Roda-Navarro P, Mittelbrunn M, Ortega M, Howie D, Terhorst C, Sánchez-Madrid F, Fernández-Ruiz E. Dynamic redistribution of the activating 2B4/SAP complex at the cytotoxic NK cell immune synapse. J Immunol. 2004 Sep 15; 173(6):3640-6.
    View in: PubMed
  3. Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S, Coyle AJ, Rajewsky K. I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion. J Immunol. 2004 Aug 1; 173(3):1612-9.
    View in: PubMed
  4. Hokama A, Mizoguchi E, Sugimoto K, Shimomura Y, Tanaka Y, Yoshida M, Rietdijk ST, de Jong YP, Snapper SB, Terhorst C, Blumberg RS, Mizoguchi A. Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity. 2004 Jun; 20(6):681-93.
    View in: PubMed
  5. Faubion WA, De Jong YP, Molina AA, Ji H, Clarke K, Wang B, Mizoguchi E, Simpson SJ, Bhan AK, Terhorst C. Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery. Gastroenterology. 2004 Jun; 126(7):1759-70.
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  6. Ji HB, Liao G, Faubion WA, Abadía-Molina AC, Cozzo C, Laroux FS, Caton A, Terhorst C. Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol. 2004 May 15; 172(10):5823-7.
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  7. Wang N, Satoskar A, Faubion W, Howie D, Okamoto S, Feske S, Gullo C, Clarke K, Sosa MR, Sharpe AH, Terhorst C. The cell surface receptor SLAM controls T cell and macrophage functions. J Exp Med. 2004 May 3; 199(9):1255-64.
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  8. Simarro M, Lanyi A, Howie D, Poy F, Bruggeman J, Choi M, Sumegi J, Eck MJ, Terhorst C. SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9. Int Immunol. 2004 May; 16(5):727-36.
    View in: PubMed
  9. de Jong YP, Rietdijk ST, Faubion WA, Abadia-Molina AC, Clarke K, Mizoguchi E, Tian J, Delaney T, Manning S, Gutierrez-Ramos JC, Bhan AK, Coyle AJ, Terhorst C. Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis. Int Immunol. 2004 Feb; 16(2):205-13.
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  10. Nagler-Anderson C, Bhan AK, Podolsky DK, Terhorst C. Control freaks: immune regulatory cells. Nat Immunol. 2004 Feb; 5(2):119-22.
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  11. Engel P, Eck MJ, Terhorst C. The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat Rev Immunol. 2003 Oct; 3(10):813-21.
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  12. Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. 2003 Feb; 5(2):155-60.
    View in: PubMed
  13. Mizoguchi A, Mizoguchi E, de Jong YP, Takedatsu H, Preffer FI, Terhorst C, Bhan AK. Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation. Int Immunol. 2003 Jan; 15(1):97-108.
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  14. Howie D, Okamoto S, Rietdijk S, Clarke K, Wang N, Gullo C, Bruggeman JP, Manning S, Coyle AJ, Greenfield E, Kuchroo V, Terhorst C. The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood. 2002 Oct 15; 100(8):2899-907.
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  15. Ji HB, Gupta A, Okamoto S, Blum MD, Tan L, Goldring MB, Lacy E, Roy AL, Terhorst C. T cell-specific expression of the murine CD3delta promoter. J Biol Chem. 2002 Dec 6; 277(49):47898-906.
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  16. Parolini O, Kagerbauer B, Simonitsch-Klupp I, Ambros P, Jaeger U, Mann G, Haas OA, Morra M, Gadner H, Terhorst C, Knapp W, Holter W. Analysis of SH2D1A mutations in patients with severe Epstein-Barr virus infections, Burkitt's lymphoma, and Hodgkin's lymphoma. Ann Hematol. 2002 Aug; 81(8):441-7.
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  17. Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P. Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. Immunogenetics. 2002 Sep; 54(6):394-402.
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  18. Sumegi J, Seemayer TA, Huang D, Davis JR, Morra M, Gross TG, Yin L, Romco G, Klein E, Terhorst C, Lanyi A. A spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnesses. Leuk Lymphoma. 2002 Jun; 43(6):1189-201.
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  19. Guirado M, de Aós I, Orta T, Rivas L, Terhorst C, Zubiaur M, Sancho J. Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells. Biochem Biophys Res Commun. 2002 Mar 1; 291(3):574-81.
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  20. Hwang PM, Li C, Morra M, Lillywhite J, Muhandiram DR, Gertler F, Terhorst C, Kay LE, Pawson T, Forman-Kay JD, Li SC. A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J. 2002 Feb 1; 21(3):314-23.
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  21. Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Blood. 2002 Feb 1; 99(3):957-65.
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  22. Fraser CC, Howie D, Morra M, Qiu Y, Murphy C, Shen Q, Gutierrez-Ramos JC, Coyle A, Kingsbury GA, Terhorst C. Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family. Immunogenetics. 2002 Feb; 53(10-11):843-50.
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  23. Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology. 2002 Jan; 122(1):134-44.
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  24. Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J. 2001 Nov 1; 20(21):5840-52.
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  25. Sohn KJ, Shah SA, Reid S, Choi M, Carrier J, Comiskey M, Terhorst C, Kim YI. Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse. Cancer Res. 2001 Sep 15; 61(18):6912-7.
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  26. Morra M, Silander O, Calpe S, Choi M, Oettgen H, Myers L, Etzioni A, Buckley R, Terhorst C. Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. Blood. 2001 Sep 1; 98(5):1321-5.
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  27. Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. J Biol Chem. 2001 Sep 28; 276(39):36809-16.
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  28. Wang N, Morra M, Wu C, Gullo C, Howie D, Coyle T, Engel P, Terhorst C. CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells. Immunogenetics. 2001 Jul; 53(5):382-94.
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  29. Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C. Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. Blood. 2001 Jun 15; 97(12):3867-74.
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  30. Wu C, Nguyen KB, Pien GC, Wang N, Gullo C, Howie D, Sosa MR, Edwards MJ, Borrow P, Satoskar AR, Sharpe AH, Biron CA, Terhorst C. SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nat Immunol. 2001 May; 2(5):410-4.
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  31. Veltkamp C, Tonkonogy SL, De Jong YP, Albright C, Grenther WB, Balish E, Terhorst C, Sartor RB. Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice. Gastroenterology. 2001 Mar; 120(4):900-13.
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  32. Morra M, Howie D, Grande MS, Sayos J, Wang N, Wu C, Engel P, Terhorst C. X-linked lymphoproliferative disease: a progressive immunodeficiency. Annu Rev Immunol. 2001; 19:657-82.
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  33. Nelson DL, Terhorst C. X-linked lymphoproliferative syndrome. Clin Exp Immunol. 2000 Dec; 122(3):291-5.
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  34. Sayós J, Nguyen KB, Wu C, Stepp SE, Howie D, Schatzle JD, Kumar V, Biron CA, Terhorst C. Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4. Int Immunol. 2000 Dec; 12(12):1749-57.
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  35. De Jong YP, Comiskey M, Kalled SL, Mizoguchi E, Flavell RA, Bhan AK, Terhorst C. Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration. Gastroenterology. 2000 Sep; 119(3):715-23.
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  36. Wu C, Sayos J, Wang N, Howie D, Coyle A, Terhorst C. Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease. Immunogenetics. 2000 Aug; 51(10):805-15.
    View in: PubMed
  37. Howie D, Sayos J, Terhorst C, Morra M. The gene defective in X-linked lymphoproliferative disease controls T cell dependent immune surveillance against Epstein-Barr virus. Curr Opin Immunol. 2000 Aug; 12(4):474-8.
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  38. Saubermann LJ, Beck P, De Jong YP, Pitman RS, Ryan MS, Kim HS, Exley M, Snapper S, Balk SP, Hagen SJ, Kanauchi O, Motoki K, Sakai T, Terhorst C, Koezuka Y, Podolsky DK, Blumberg RS. Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology. 2000 Jul; 119(1):119-28.
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  39. van Ewijk W, Holländer G, Terhorst C, Wang B. Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets. Development. 2000 Apr; 127(8):1583-91.
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  40. Simpson SJ, de Jong YP, Comiskey M, Terhorst C. Pathways of T cell pathology in models of chronic intestinal inflammation. Int Rev Immunol. 2000; 19(1):1-37.
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  41. Satoskar AR, Stamm LM, Zhang X, Okano M, David JR, Terhorst C, Wang B. NK cell-deficient mice develop a Th1-like response but fail to mount an efficient antigen-specific IgG2a antibody response. J Immunol. 1999 Nov 15; 163(10):5298-302.
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  42. Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell. 1999 Oct; 4(4):555-61.
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  43. Zubiaur M, Guirado M, Terhorst C, Malavasi F, Sancho J. The CD3-gamma delta epsilon transducing module mediates CD38-induced protein-tyrosine kinase and mitogen-activated protein kinase activation in Jurkat T cells. J Biol Chem. 1999 Jul 16; 274(29):20633-42.
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  44. Satoskar AR, Stamm LM, Zhang X, Satoskar AA, Okano M, Terhorst C, David JR, Wang B. Mice lacking NK cells develop an efficient Th1 response and control cutaneous Leishmania major infection. J Immunol. 1999 Jun 1; 162(11):6747-54.
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  45. Levelt CN, de Jong YP, Mizoguchi E, O'Farrelly C, Bhan AK, Tonegawa S, Terhorst C, Simpson SJ. High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5628-33.
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  46. She J, Ruzek MC, Velupillai P, de Aos I, Wang B, Harn DA, Sancho J, Biron CA, Terhorst C. Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3zeta. Int Immunol. 1999 May; 11(5):845-57.
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  47. Wang B, Wang N, Whitehurst CE, She J, Chen J, Terhorst C. T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta. J Immunol. 1999 Jan 1; 162(1):88-94.
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  48. Wang N, Wang B, Salio M, Allen D, She J, Terhorst C. Expression of a CD3 epsilon transgene in CD3 epsilon(null) mice does not restore CD3 gamma and delta expression but efficiently rescues T cell development from a subpopulation of prothymocytes. Int Immunol. 1998 Dec; 10(12):1777-88.
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  49. Gold DP, Clevers H, Alarcon B, Dunlap S, Novotny J, Williams AF, Terhorst C. Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proc Natl Acad Sci U S A. 1987 Nov; 84(21):7649-53.
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  50. Biron CA, van den Elsen P, Tutt MM, Medveczky P, Kumar V, Terhorst C. Murine natural killer cells stimulated in vivo do not express the T cell receptor alpha, beta, gamma, T3 delta, or T3 epsilon genes. J Immunol. 1987 Sep 1; 139(5):1704-10.
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  51. Alarcon B, De Vries J, Pettey C, Boylston A, Yssel H, Terhorst C, Spits H. The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone. Proc Natl Acad Sci U S A. 1987 Jun; 84(11):3861-5.
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  52. Pettey CL, Alarcon B, Malin R, Weinberg K, Terhorst C. T3-p28 is a protein associated with the delta and epsilon chains of the T cell receptor-T3 antigen complex during biosynthesis. J Biol Chem. 1987 Apr 5; 262(10):4854-9.
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  53. Umetsu DT, Katzen D, Chatila T, Miller R, Jabara HH, Maher M, Oettgen H, Terhorst C, Geha RS. Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3. Clin Immunol Immunopathol. 1987 Apr; 43(1):48-64.
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  54. Oettgen HC, Terhorst C. The T-cell receptor-T3 complex and T-lymphocyte activation. Hum Immunol. 1987 Mar; 18(3):187-204.
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  55. Gold DP, van Dongen JJ, Morton CC, Bruns GA, van den Elsen P, Geurts van Kessel AH, Terhorst C. The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice. Proc Natl Acad Sci U S A. 1987 Mar; 84(6):1664-8.
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  56. Oettgen HC, Terhorst C. A review of the structure and function of the T-cell receptor-T3 complex. Crit Rev Immunol. 1987; 7(2):131-67.
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  57. Reiser H, Oettgen H, Yeh ET, Terhorst C, Low MG, Benacerraf B, Rock KL. Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. Cell. 1986 Nov 7; 47(3):365-70.
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  58. Furley AJ, Reeves BR, Mizutani S, Altass LJ, Watt SM, Jacob MC, van den Elsen P, Terhorst C, Greaves MF. Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines. Blood. 1986 Nov; 68(5):1101-7.
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  59. MacLeod CL, Minning L, Gold DP, Terhorst C, Wilkinson M. Negative trans-regulation of T-cell antigen receptor/T3 complex mRNA expression in murine T-lymphoma somatic cell hybrids. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6989-93.
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  60. Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C. Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex. Nature. 1986 May 22-28; 321(6068):431-4.
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  61. van den Elsen P, Georgopoulos K, Shepley BA, Orkin S, Terhorst C. Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. Proc Natl Acad Sci U S A. 1986 May; 83(9):2944-8.
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  62. Spits H, van Schooten W, Keizer H, van Seventer G, van de Rijn M, Terhorst C, de Vries JE. Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells. Science. 1986 Apr 18; 232(4748):403-5.
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  63. Oettgen HC, Pettey CL, Maloy WL, Terhorst C. A T3-like protein complex associated with the antigen receptor on murine T cells. Nature. 1986 Mar 20-26; 320(6059):272-5.
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  64. Lerch PG, van de Rijn M, Smart JE, Knowles RW, Terhorst C. Isolation and purification of the human thymocyte antigens T6 and M241. Mol Immunol. 1986 Feb; 23(2):131-9.
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  65. Terhorst C, de Vries J, Georgopoulos K, Gold D, Oettgen H, Pettey C, Spits H, Ucker D, van den Elsen P, Wileman T. The T cell receptor/T3 complex. Year Immunol. 1986; 2:245-53.
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  66. Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J. The role of the T3/antigen receptor complex in T-cell activation. Annu Rev Immunol. 1986; 4:593-619.
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  67. Keizer GD, Borst J, Figdor CG, Spits H, Miedema F, Terhorst C, De Vries JE. Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1 and p150,95. Eur J Immunol. 1985 Nov; 15(11):1142-8.
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  68. Spits H, Borst J, Tax W, Capel PJ, Terhorst C, de Vries JE. Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen. J Immunol. 1985 Sep; 135(3):1922-8.
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  69. Ohashi PS, Mak TW, Van den Elsen P, Yanagi Y, Yoshikai Y, Calman AF, Terhorst C, Stobo JD, Weiss A. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature. 1985 Aug 15-21; 316(6029):606-9.
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  70. Bernabeu C, Maziarz R, Murre C, Terhorst C. beta 2-Microglobulin from serum associates with several class I antigens expressed on the surface of mouse L-cells. Mol Immunol. 1985 Aug; 22(8):955-60.
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  71. Terhorst C. Structure and function of the T3/T cell receptor complex. Behring Inst Mitt. 1985 Aug; (77):22-9.
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  72. Samelson LE, Lindsten T, Fowlkes BJ, van den Elsen P, Terhorst C, Davis MM, Germain RN, Schwartz RH. Expression of genes of the T-cell antigen receptor complex in precursor thymocytes. Nature. 1985 Jun 27-Jul 3; 315(6022):765-8.
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  73. Snow PM, Van de Rijn M, Terhorst C. Association between the human thymic differentiation antigens T6 and T8. Eur J Immunol. 1985 May; 15(5):529-32.
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  74. van den Elsen P, Bruns G, Gerhard DS, Pravtcheva D, Jones C, Housman D, Ruddle FA, Orkin S, Terhorst C. Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9. Proc Natl Acad Sci U S A. 1985 May; 82(9):2920-4.
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  75. van den Elsen P, Shepley BA, Cho M, Terhorst C. Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. Nature. 1985 Apr 11-17; 314(6011):542-4.
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  76. Snow PM, Coligan JE, Terhorst C. Analysis of the structure of the human T cell surface antigen T8 by limited proteolysis and chemical cleavage. J Biol Chem. 1985 Mar 10; 260(5):2700-8.
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  77. Oettgen HC, Terhorst C, Cantley LC, Rosoff PM. Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. Cell. 1985 Mar; 40(3):583-90.
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  78. Pessano S, Oettgen H, Bhan AK, Terhorst C. The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits. EMBO J. 1985 Feb; 4(2):337-44.
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  79. Terhorst C, van den Elsen P. The T-cell receptor/T3 complex. Year Immunol. 1985; 62-73.
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  80. Terhorst C. Structure and function of the T cell receptor/T3 complex. Prog Clin Biol Res. 1985; 184:317-29.
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  81. Yoshikai Y, Anatoniou D, Clark SP, Yanagi Y, Sangster R, Van den Elsen P, Terhorst C, Mak TW. Sequence and expression of transcripts of the human T-cell receptor beta-chain genes. Nature. 1984 Dec 6-12; 312(5994):521-4.
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  82. Bernabeu C, Maziarz R, Spits H, de Vries J, Burakoff SJ, Terhorst C. Coexpression of the human HLA-A2 or HLA-B7 heavy chain gene and human beta 2-microglobulin gene in L cells. J Immunol. 1984 Dec; 133(6):3188-94.
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  83. van de Rijn M, Bernabeu C, Royer-Pokora B, Weiss J, Seidman JG, de Vries J, Spits H, Terhorst C. Recognition of HLA-A2 by cytotoxic T lymphocytes after DNA transfer into human and murine cells. Science. 1984 Nov 30; 226(4678):1083-5.
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  84. van den Elsen P, Shepley BA, Borst J, Coligan JE, Markham AF, Orkin S, Terhorst C. Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. Nature. 1984 Nov 29-Dec 5; 312(5993):413-8.
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  85. Borst J, Coligan JE, Oettgen H, Pessano S, Malin R, Terhorst C. The delta- and epsilon-chains of the human T3/T-cell receptor complex are distinct polypeptides. Nature. 1984 Nov 29-Dec 5; 312(5993):455-8.
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  86. Oettgen HC, Kappler J, Tax WJ, Terhorst C. Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes. J Biol Chem. 1984 Oct 10; 259(19):12039-48.
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  87. Arnaout MA, Spits H, Terhorst C, Pitt J, Todd RF. Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest. 1984 Oct; 74(4):1291-300.
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  88. Snow PM, Keizer G, Coligan JE, Terhorst C. Purification and N-terminal amino acid sequence of the human T cell surface antigen T8. J Immunol. 1984 Oct; 133(4):2058-66.
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  89. Bernabeu C, van de Rijn M, Lerch PG, Terhorst CP. Beta 2-microglobulin from serum associates with MHC class I antigens on the surface of cultured cells. Nature. 1984 Apr 12-18; 308(5960):642-5.
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  90. van de Rijn M, Lerch PG, Bronstein BR, Knowles RW, Bhan AK, Terhorst C. Human cutaneous dendritic cells express two glycoproteins T6 and M241 which are biochemically identical to those found on cortical thymocytes. Hum Immunol. 1984 Apr; 9(4):201-10.
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  91. Spits H, Borst J, Giphart M, Coligan J, Terhorst C, De Vries JE. HLA-DC antigens can serve as recognition elements for human cytotoxic T lymphocytes. Eur J Immunol. 1984 Apr; 14(4):299-304.
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  92. Snow PM, Terhorst C. The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes. J Biol Chem. 1983 Dec 10; 258(23):14675-81.
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  93. Pessano S, Bottero L, Faust J, Trucco M, Palumbo A, Pegoraro L, Lange B, Brezin C, Borst J, Terhorst C, Rovera G. Differentiation antigens of human hemopoietic cells: patterns of reactivity of two monoclonal antibodies. Cancer Res. 1983 Oct; 43(10):4812-5.
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  94. Bernabeu C, Finlay D, van de Rijn M, Maziarz RT, Biro PA, Spits H, de Vries J, Terhorst CP. Expression of the major histocompatibility antigens HLA-A2 and HLA-B7 by DNA-mediated gene transfer. J Immunol. 1983 Oct; 131(4):2032-7.
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  95. van de Rijn M, Lerch PG, Knowles RW, Terhorst C. The thymic differentiation markers T6 and M241 are two unusual MHC class I antigens. J Immunol. 1983 Aug; 131(2):851-5.
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  96. Borst J, Prendiville MA, Terhorst C. The T3 complex on human thymus-derived lymphocytes contains two different subunits of 20 kDa. Eur J Immunol. 1983 Jul; 13(7):576-80.
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  97. Perussia B, Acuto O, Terhorst C, Faust J, Lazarus R, Fanning V, Trinchieri G. Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. II. Studies of B73.1 antibody-antigen interaction on the lymphocyte membrane. J Immunol. 1983 May; 130(5):2142-8.
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  98. Borst J, Alexander S, Elder J, Terhorst C. The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins. J Biol Chem. 1983 Apr 25; 258(8):5135-41.
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  99. Oettgen HC, Bayard PJ, Van Ewijk W, Nadler LM, Terhorst CP. Further biochemical studies of the human B-cell differentiation antigens B1 and B2. Hybridoma. 1983; 2(1):17-28.
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  100. Spits H, Keizer G, Borst J, Terhorst C, Hekman A, de Vries JE. Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma. 1983; 2(4):423-37.
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  101. Snow P, Spits H, De Vries J, Terhorst C. Comparison of target antigens of monoclonal reagents OKT5, OKT8, and Leu2A, which inhibit effector function of human cytotoxic T lymphocytes. Hybridoma. 1983; 2(2):187-99.
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  102. Borst J, Spits H, de Vries J, Pessano S, Rovera G, Terhorst C. Target antigen of monoclonal reagent S5.7: comparison with T3 antigen. Hybridoma. 1983; 2(3):265-74.
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  103. Lerch PG, van de Rijn M, Schrier P, Terhorst C. Biochemical comparison of the T6 antigen and HLA-A,B antigens. Hum Immunol. 1983 Jan; 6(1):13-30.
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  104. van de Rijn M, Geurts van Kessel AH, Kroezen V, van Agthoven AJ, Verstijnen K, Terhorst C, Hilgers J. Localization of a gene controlling the expression of the human transferrin receptor to the region q12 leads to qter of chromosome 3. Cytogenet Cell Genet. 1983; 36(3):525-31.
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  105. Terhorst C, Borst J, Lerch P, van de Rijn M, Snow P, Spits H, de Vries J. Structural and functional aspects of the T-cell differentiation antigens T3, T6, and T8. Haematol Blood Transfus. 1983; 28:440-6.
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  106. Spits H, Borst J, Terhorst C, de Vries JE. The role of T cell differentiation markers in antigen-specific and lectin-dependent cellular cytotoxicity mediated by T8+ and T4+ human cytotoxic T cell clones directed at class I and class II MHC antigens. J Immunol. 1982 Oct; 129(4):1563-9.
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  107. Borst J, Prendiville MA, Terhorst C. Complexity of the human T lymphocyte-specific cell surface antigen T3. J Immunol. 1982 Apr; 128(4):1560-5.
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  108. Spits H, Ijssel H, Terhorst C, de Vries JE. Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: isolation of clones that differ in phenotype and specificity. J Immunol. 1982 Jan; 128(1):95-9.
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  109. Todd RF, Van Agthoven A, Schlossman SF, Terhorst C. Structural analysis of differentiation antigens Mo1 and Mo2 on human monocytes. Hybridoma. 1982; 1(3):329-37.
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  110. van Agthoven A, Terhorst C. Further biochemical characterization of the human thymocyte differentiation antigen T6. J Immunol. 1982 Jan; 128(1):426-32.
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  111. Reinherz EL, Hussey RE, Fitzgerald K, Snow P, Terhorst C, Schlossman SF. Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes. Nature. 1981 Nov 12; 294(5837):168-70.
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  112. Spits H, de Vries JE, Terhorst C. The cell-mediated lympholysis-inducing capacity of highly purified human monocytes and T lymphocytes in primary and secondary mixed leukocyte cultures. J Immunol. 1981 Jun; 126(6):2275-8.
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  113. Nadler LM, Stashenko P, Hardy R, van Agthoven A, Terhorst C, Schlossman SF. Characterization of a human B cell-specific antigen (B2) distinct from B1. J Immunol. 1981 May; 126(5):1941-7.
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  114. Spits H, de Vries JE, Terhorst C. A permanent human cytotoxic T-cell line with high killing capacity against a lymphoblastoid B-cell line shows preference for HLA A, B target antigens and lacks spontaneous cytotoxic activity. Cell Immunol. 1981 Apr; 59(2):435-47.
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  115. Maassen JA, Terhorst C. Identification of a cell-surface protein involved in the binding site of Sindbis virus on human lymphoblastic cell lines using a heterobifunctional cross-linker. Eur J Biochem. 1981 Mar 16; 115(1):153-8.
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  116. Terhorst C, van Agthoven A, LeClair K, Snow P, Reinherz E, Schlossman S. Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10. Cell. 1981 Mar; 23(3):771-80.
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  117. Terhorst C, Leclair K, Ma A, Slayter H. Protein micelles of human histocompatibility antigens (HLA-A and HLA-B). Mol Immunol. 1981 Feb; 18(2):103-12.
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  118. LeClair K, Van Agthoven A, Terhorst C. A rapid method for isolation of antigenically active human cell surface antigens associated with beta 2-microglobulin using a monoclonal antibody. J Immunol Methods. 1981; 41(2):137-44.
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  119. van Agthoven A, Terhorst C, Reinherz E, Schlossman S. Characterization of T cell surface glycoproteins T 1 and T 3 present on all human peripheral T lymphocytes and functionally mature thymocytes. Eur J Immunol. 1981 Jan; 11(1):18-21.
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  120. Gazit E, Terhorst C, Mahoney RJ, Yunis EJ. Alloantigens of the human T (HT) genetic region of the HLA linkage group. Hum Immunol. 1980 Sep; 1(2):97-109.
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  121. Terhorst C, van Agthoven A, Reinherz E, Schlossman S. Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5. Science. 1980 Jul 25; 209(4455):520-1.
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  122. Pesando JM, Ritz J, Levine H, Terhorst C, Lazarus H, Schlossman SF. Human leukemia-associated antigen: relation to a family of surface glycoproteins. J Immunol. 1980 Jun; 124(6):2794-9.
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  123. Gazit E, Terhorst C, Yunis EJ. The human 'T' genetic region of the HLA linkage group is a polymorphism detected on lectin-activated lymphocytes. Nature. 1980 Mar 20; 284(5753):275-7.
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  124. Strominger JL, Kabat EA, Bilofsky H, Mann D, Orr H, Parham P, Ploegh H, Robb R, Terhorst C, Wu TT. Structural and sequence homologies between HLA-A and HLA-B antigens and immunoglobulins. Transplant Proc. 1979 Jun; 11(2):1303.
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  125. Ferguson WS, Terhorst CT, Robb RJ, Strominger JL. Localization of the disulfide bridges of human histocompatibility antigens. Mol Immunol. 1979 Jan; 16(1):23-8.
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  126. Robb RJ, Terhorst C, Strominger JL. Sequence of the COOH-terminal hydrophilic region of histocompatibility antigens HLA-A2 and HLA-B7. J Biol Chem. 1978 Aug 10; 253(15):5319-24.
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  127. Helenius A, Morein B, Fries E, Simons K, Robinson P, Schirrmacher V, Terhorst C, Strominger JL. Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus. Proc Natl Acad Sci U S A. 1978 Aug; 75(8):3846-50.
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  128. Engelhard VH, Guild BC, Helenius A, Terhorst C, Strominger JL. Reconstitution of purified detergent-soluble HLA-A and HLA-B antigens into phospholipid vesicles. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3230-4.
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  129. Strominger JL, Ferguson W, Fuks A, Giphart M, Kaufman J, Mann D, Orr H, Parham P, Robb R, Terhorst C. Isolation and structure of HLA antigens. Birth Defects Orig Artic Ser. 1978; 14(2):235-46.
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  130. Fuks A, Kaufman JF, Orr HT, Parham P, Robb RR, Terhorst C, Strominger JL. Structural aspects of the products of the human major histocompatibility complex. Transplant Proc. 1977 Dec; 9(4):1685-9.
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  131. Terhorst C, Robb R, Jones C, Strominger JL. Further structural studies of the heavy chain of HLA antigens and its similarity to immunoglobulins. Proc Natl Acad Sci U S A. 1977 Sep; 74(9):4002-6.
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  132. Springer TA, Kaufman JF, Terhorst C, Strominger JL. Purification and structural characterisation of human HLA-linked B-cell antigens. Nature. 1977 Jul 21; 268(5617):213-8.
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  133. Springer TA, Robb RJ, Terhorst C, Strominger JL. Submit and disulfide structure of monomeric and dimeric forms of detergent-soluble HLA antigens. J Biol Chem. 1977 Jul 10; 252(13):4694-700.
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  134. Strominger JL, Mann DL, Parham P, Robb R, Springer T, Terhorst C. Structure of HL-A A and B antigens isolated from cultured human lymphocytes. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:323-9.
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  135. Springer TA, Kaufman JF, Siddoway LA, Giphart M, Mann DL, Terhorst C, Strominger JL. Chemical and immunological characterization of HL-A linked B-lymphocyte alloantigens. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:387-96.
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  136. Strominger JL, Humphreys RE, McCune JM, Parham P, Robb R, Springer T, Terhorst C. The immunoglobulin-like structure of human histocompatibility antigens. Fed Proc. 1976 Apr; 35(5):1177-82.
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  137. Terhorst C, Parham P, Mann DL, Strominger JL. Structure of HLA antigens: amino-acid and carbohydrate compositions and NH2-terminal sequences of four antigen preparations. Proc Natl Acad Sci U S A. 1976 Mar; 73(3):910-4.
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  138. Parham P, Terhorst C, Herrmann H, Humphreys RE, Waterfield MD, Strominger JL. Immunological and chemical purity of papain-solubilized HL-A antigens. Proc Natl Acad Sci U S A. 1975 Apr; 72(4):1594-8.
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  139. Strominger JL, Cresswell P, Grey H, Humphreys RE, Mann D. The immunoglobulin-like structure of human histocompatibility antigens. Transplant Rev. 1974; 21(0):126-43.
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  140. Terhorst C, Möller W, Laursen R, Wittmann-Liebold B. The primary structure of an acidic protein from 50-S ribosomes of Escherichia coli which is involved in GTP hydrolysis dependent on elongation factors G and T. Eur J Biochem. 1973 Apr 2; 34(1):138-52.
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  141. Terhorst C, Möller W, Laursen R, Wittmann-Liebold B. Amino acid sequence of a 50 S ribosomal protein involved in both EFG and EFT dependent GTP-hydrolysis. FEBS Lett. 1972 Dec 15; 28(3):325-328.
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  142. Terhorst C, Wittmann-Liebold B, Möller W. 50-S ribosomal proteins. Peptide studies on two acidic proteins, A 1 and A 2 , isolated from 50-S ribosomes of Escherichia coli. Eur J Biochem. 1972 Jan 31; 25(1):13-9.
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  143. Möller W, Groene A, Terhorst C, Amons R. 50-S ribosomal proteins. Purification and partial characterization of two acidic proteins, A 1 and A 2, isolated from 50-S ribosomes of Escherichia coli. Eur J Biochem. 1972 Jan 31; 25(1):5-12.
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  144. Möller W, Castleman H, Terhorst CP. Characterization of an acidic protein in 50 s ribosomes of E. coli. FEBS Lett. 1970 Jun 8; 8(4):192-196.
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  145. Möller W, Amons R, Groene JC, Garrett RA, Terhorst CP. Protein-ribonucleic acid interactions in ribosomes. Biochim Biophys Acta. 1969 Oct 22; 190(2):381-90.
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  146. van Eyk HG, Terhorst C, de Vijlder MM. Fragmentation of human IgG globulin with papain, trypsin and pepsin. Clin Chim Acta. 1967 Jun; 16(3):429-31.
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