Tatsuo Kawai, PH.D., M.D.
|Title||Associate Professor of Surgery|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
55 Fruit St
Boston MA 02114
Available: 11/01/11, Expires: 10/01/14
Induction of immunological tolerance is an ultimate goal of organ transplantation. In our lab, using nonhuman primates (NHP), tolerance has been studied with the mixed chimerism approach in kidney, heart and lung transplantation. Our results in NHP have been successfully translated in clinical kidney transplantation. Our current research interests are “How chimerism (even transient) induces allograft tolerance? “How each organ is involved in the maintenance of tolerance?” “ How T regulatory cells (Tregs) are involved in tolerance induction and maintenance” “ How Tregs can be expanded in vivo or in vitro and how they can be applied to clinical organ transplantation” As a research assistant, you will have an opportunity to be involved in above exciting research projects by performing various immunological assays (FACS, ELISPOT, RT-PCR etc.).
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