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Manoj T. Duraisingh, Ph.D.

TitleAssociate Professor of Immunology and Infectious Diseases
InstitutionHarvard School of Public Health
DepartmentMalaria/Wirth
AddressHarvard School of Public Health
Bldg 1, Rm 715
665 Huntington Ave
Boston MA 02115
Phone617/432-2675

 Mentoring 
 completed student projects
Genetic analysis of how Duffy antigen expression level affects erythrocyte susceptibility to vivax malaria infection
Summer, 06/20/11 - 08/12/11

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Horn D, Duraisingh MT. Antiparasitic chemotherapy: from genomes to mechanisms. Annu Rev Pharmacol Toxicol. 2014 Jan 6; 54:71-94.
    View in: PubMed
  2. Patel SD, Ahouidi AD, Bei AK, Dieye TN, Mboup S, Harrison SC, Duraisingh MT. Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans. J Infect Dis. 2013 Nov; 208(10):1679-87.
    View in: PubMed
  3. Engelberg K, Paul AS, Prinz B, Kono M, Ching W, Heincke D, Dobner T, Spielmann T, Duraisingh MT, Gilberger TW. Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum. Biochem J. 2013 Jun 15; 452(3):457-66.
    View in: PubMed
  4. Badiane AS, Bei AK, Ahouidi AD, Patel SD, Salinas N, Ndiaye D, Sarr O, Ndir O, Tolia NH, Mboup S, Duraisingh MT. Inhibitory Humoral Responses to the Plasmodium falciparum Vaccine Candidate EBA-175 Are Independent of the Erythrocyte Invasion Pathway. Clin Vaccine Immunol. 2013 Aug; 20(8):1238-45.
    View in: PubMed
  5. Lim C, Hansen E, Desimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MT. Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nat Commun. 2013 Mar 27; 4:1638.
    View in: PubMed
  6. Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. Nuclear Repositioning Precedes Promoter Accessibility and Is Linked to the Switching Frequency of a Plasmodium falciparum Invasion Gene. Cell Host Microbe. 2012 Dec 13; 12(6):739-50.
    View in: PubMed
  7. Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S. Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. J Infect Dev Ctries. 2012 Oct; 6(10):727-33.
    View in: PubMed
  8. Gubbels MJ, Duraisingh MT. Evolution of apicomplexan secretory organelles. Int J Parasitol. 2012 Nov; 42(12):1071-81.
    View in: PubMed
  9. Vorobjev IA, Buchholz K, Prabhat P, Ketman K, Egan ES, Marti M, Duraisingh MT, Barteneva NS. Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters. Malar J. 2012; 11:312.
    View in: PubMed
  10. Duraisingh MT, Lodish HF. Sickle cell microRNAs inhibit the malaria parasite. Cell Host Microbe. 2012 Aug 16; 12(2):127-8.
    View in: PubMed
  11. Bei AK, Duraisingh MT. Functional analysis of erythrocyte determinants of Plasmodium infection. Int J Parasitol. 2012 May 15; 42(6):575-82.
    View in: PubMed
  12. Merrick CJ, Huttenhower C, Buckee C, Amambua-Ngwa A, Gomez-Escobar N, Walther M, Conway DJ, Duraisingh MT. Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria. J Infect Dis. 2012 May 15; 205(10):1593-600.
    View in: PubMed
  13. Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowble J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, Shastri J, Smith J, Valecha N, White J, Rathod PK. Malaria evolution in South Asia: knowledge for control and elimination. Acta Trop. 2012 Mar; 121(3):256-66.
    View in: PubMed
  14. Farrell A, Thirugnanam S, Lorestani A, Dvorin JD, Eidell KP, Ferguson DJ, Anderson-White BR, Duraisingh MT, Marth GT, Gubbels MJ. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science. 2012 Jan 13; 335(6065):218-21.
    View in: PubMed
  15. Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10.
    View in: PubMed
  16. Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D'Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop. 2012 Mar; 121(3):175-83.
    View in: PubMed
  17. Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop. 2012 Mar; 121(3):166-74.
    View in: PubMed
  18. Crosnier C, Bustamante LY, Bartholdson SJ, Bei AK, Theron M, Uchikawa M, Mboup S, Ndir O, Kwiatkowski DP, Duraisingh MT, Rayner JC, Wright GJ. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature. 2011 Dec 22; 480(7378):534-7.
    View in: PubMed
  19. Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol. 2011; 12(6):R56.
    View in: PubMed
  20. Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Jun; 55(6):2612-22.
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  21. Comeaux CA, Coleman BI, Bei AK, Whitehurst N, Duraisingh MT. Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth. Mol Microbiol. 2011 Apr; 80(2):378-90.
    View in: PubMed
  22. Bei AK, Brugnara C, Duraisingh MT. In vitro genetic analysis of an erythrocyte determinant of malaria infection. J Infect Dis. 2010 Dec 1; 202(11):1722-7.
    View in: PubMed
  23. Booker ML, Bastos CM, Kramer ML, Barker RH, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Oct 22; 285(43):33054-64.
    View in: PubMed
  24. Merrick CJ, Duraisingh MT. Epigenetics in Plasmodium: what do we really know? Eukaryot Cell. 2010 Aug; 9(8):1150-8.
    View in: PubMed
  25. Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science. 2010 May 14; 328(5980):910-2.
    View in: PubMed
  26. Bei AK, Desimone TM, Badiane AS, Ahouidi AD, Dieye T, Ndiaye D, Sarr O, Ndir O, Mboup S, Duraisingh MT. A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. Am J Hematol. 2010 Apr; 85(4):234-7.
    View in: PubMed
  27. Dvorin JD, Bei AK, Coleman BI, Duraisingh MT. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol. 2010 Feb; 75(4):990-1006.
    View in: PubMed
  28. Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem. 2010 Feb 26; 285(9):6857-66.
    View in: PubMed
  29. Ahouidi AD, Bei AK, Neafsey DE, Sarr O, Volkman S, Milner D, Cox-Singh J, Ferreira MU, Ndir O, Premji Z, Mboup S, Duraisingh MT. Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens. Infect Genet Evol. 2010 Mar; 10(2):200-6.
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  30. Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J. Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell. 2010 Feb; 9(2):228-41.
    View in: PubMed
  31. Merrick CJ, Dzikowski R, Imamura H, Chuang J, Deitsch K, Duraisingh MT. The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. Int J Parasitol. 2010 Jan; 40(1):35-43.
    View in: PubMed
  32. DeSimone TM, Jennings CV, Bei AK, Comeaux C, Coleman BI, Refour P, Triglia T, Stubbs J, Cowman AF, Duraisingh MT. Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes. Mol Microbiol. 2009 May; 72(3):578-89.
    View in: PubMed
  33. Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem. 2009 Apr 23; 52(8):2185-7.
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  34. Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Silva LM, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF. Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol. 2009 Apr 14; 7(4):e84.
    View in: PubMed
  35. Lantos PM, Ahouidi AD, Bei AK, Jennings CV, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitology. 2009 Jan; 136(1):1-9.
    View in: PubMed
  36. Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 1; 19(3):972-5.
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  37. Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85.
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  38. DeSimone TM, Bei AK, Jennings CV, Duraisingh MT. Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum. Int J Parasitol. 2009 Mar; 39(4):399-405.
    View in: PubMed
  39. Coleman BI, Duraisingh MT. Transcriptional control and gene silencing in Plasmodium falciparum. Cell Microbiol. 2008 Oct; 10(10):1935-46.
    View in: PubMed
  40. Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler EA. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One. 2008; 3(2):e1570.
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  41. Duraisingh MT, DeSimone T, Jennings C, Refour P, Wu C. Erythrocyte invasion by Plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching. Subcell Biochem. 2008; 47:46-57.
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  42. Comeaux CA, Duraisingh MT. Unravelling a histone code for malaria virulence. Mol Microbiol. 2007 Dec; 66(6):1291-5.
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  43. Militello KT, Refour P, Comeaux CA, Duraisingh MT. Antisense RNA and RNAi in protozoan parasites: working hard or hardly working? Mol Biochem Parasitol. 2008 Feb; 157(2):117-26.
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  44. Merrick CJ, Duraisingh MT. Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. Eukaryot Cell. 2007 Nov; 6(11):2081-91.
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  45. Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. Mechanisms of gene regulation in Plasmodium. Am J Trop Med Hyg. 2007 Aug; 77(2):201-8.
    View in: PubMed
  46. Jennings CV, Ahouidi AD, Zilversmit M, Bei AK, Rayner J, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal. Infect Immun. 2007 Jul; 75(7):3531-8.
    View in: PubMed
  47. Bei AK, Membi CD, Rayner JC, Mubi M, Ngasala B, Sultan AA, Premji Z, Duraisingh MT. Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania. Mol Biochem Parasitol. 2007 May; 153(1):66-71.
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  48. Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF. A genome-wide map of diversity in Plasmodium falciparum. Nat Genet. 2007 Jan; 39(1):113-9.
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  49. Merrick CJ, Duraisingh MT. Heterochromatin-mediated control of virulence gene expression. Mol Microbiol. 2006 Nov; 62(3):612-20.
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  50. Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol Microbiol. 2006 Sep; 61(5):1187-95.
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  51. Duraisingh M, Ferdig MT, Stoeckert CJ, Volkman SK, McGovern VP. Plasmodium research in the postgenomic era. Trends Parasitol. 2006 Jan; 22(1):1-4.
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  52. Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science. 2005 Aug 26; 309(5739):1384-7.
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  53. Duraisingh MT, Refour P. Multiple drug resistance genes in malaria -- from epistasis to epidemiology. Mol Microbiol. 2005 Aug; 57(4):874-7.
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  54. Duraisingh MT, Cowman AF. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop. 2005 Jun; 94(3):181-90.
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  55. Duraisingh MT, Voss TS, Marty AJ, Duffy MF, Good RT, Thompson JK, Freitas-Junior LH, Scherf A, Crabb BS, Cowman AF. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell. 2005 Apr 8; 121(1):13-24.
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  56. Triglia T, Duraisingh MT, Good RT, Cowman AF. Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol. 2005 Jan; 55(1):162-74.
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  57. Duraisingh MT, Maier AG, Triglia T, Cowman AF. Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4796-801.
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  58. Duraisingh MT, Triglia T, Ralph SA, Rayner JC, Barnwell JW, McFadden GI, Cowman AF. Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J. 2003 Mar 3; 22(5):1047-57.
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  59. Ngo T, Duraisingh M, Reed M, Hipgrave D, Biggs B, Cowman AF. Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin. Am J Trop Med Hyg. 2003 Mar; 68(3):350-6.
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  60. Gilberger TW, Thompson JK, Triglia T, Good RT, Duraisingh MT, Cowman AF. A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem. 2003 Apr 18; 278(16):14480-6.
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  61. Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, Zimmerman PA, Cowman AF. Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med. 2003 Jan; 9(1):87-92.
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  62. Sutherland CJ, Alloueche A, Curtis J, Drakeley CJ, Ord R, Duraisingh M, Greenwood BM, Pinder M, Warhurst D, Targett GA. Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes. Am J Trop Med Hyg. 2002 Dec; 67(6):578-85.
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  63. Baldi DL, Good R, Duraisingh MT, Crabb BS, Cowman AF. Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum. Infect Immun. 2002 Sep; 70(9):5236-45.
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  64. Sangster N, Batterham P, Chapman HD, Duraisingh M, Le Jambre L, Shirley M, Upcroft J, Upcroft P. Resistance to antiparasitic drugs: the role of molecular diagnosis. Int J Parasitol. 2002 May; 32(5):637-53.
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  65. O'Donnell RA, Freitas-Junior LH, Preiser PR, Williamson DH, Duraisingh M, McElwain TF, Scherf A, Cowman AF, Crabb BS. A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J. 2002 Mar 1; 21(5):1231-9.
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  66. Cowman AF, Baldi DL, Duraisingh M, Healer J, Mills KE, O'Donnell RA, Thompson J, Triglia T, Wickham ME, Crabb BS. Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philos Trans R Soc Lond B Biol Sci. 2002 Jan 29; 357(1417):25-33.
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  67. Duraisingh MT, Triglia T, Cowman AF. Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol. 2002 Jan; 32(1):81-9.
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  68. Warhurst DC, Duraisingh MT. Rational use of drugs against Plasmodium falciparum. Trans R Soc Trop Med Hyg. 2001 Jul-Aug; 95(4):345-6.
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  69. Cowman AF, Duraisingh MT. An old enemy, a new battle plan. Perspective on combating drug-resistant malaria. EMBO Rep. 2001 Feb; 2(2):77-9.
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  70. Duraisingh MT, von Seidlein LV, Jepson A, Jones P, Sambou I, Pinder M, Warhurst DC. Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum. Parasitology. 2000 Jul; 121 ( Pt 1):1-7.
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  71. Duraisingh MT, Roper C, Walliker D, Warhurst DC. Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol. 2000 May; 36(4):955-61.
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  72. Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol. 2000 Apr 30; 108(1):13-23.
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  73. von Seidlein L, Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, Coleman R, Ude JI, Sadiq A, Duraisingh M, Warhurst D, Alloueche A, Targett G, McAdam K, Greenwood B, Walraven G, Olliaro P, Doherty T. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet. 2000 Jan 29; 355(9201):352-7.
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  74. Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother. 1999 Dec; 43(12):2943-9.
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  75. Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study. Parasitology. 1999 Nov; 119 ( Pt 5):435-40.
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  76. Jelinek T, Kilian AH, Curtis J, Duraisingh MT, Kabagambe G, von Sonnenburg F, Warhurst DC. Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children. Am J Trop Med Hyg. 1999 Jul; 61(1):125-30.
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  77. Jelinek T, Rønn AM, Lemnge MM, Curtis J, Mhina J, Duraisingh MT, Bygbjerg IC, Warhurst DC. Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania. Trop Med Int Health. 1998 Aug; 3(8):605-9.
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  78. Curtis J, Duraisingh MT, Warhurst DC. In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. J Infect Dis. 1998 May; 177(5):1429-33.
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  79. Duraisingh MT, Curtis J, Warhurst DC. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol. 1998 May; 89(1):1-8.
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  80. Jelinek T, Rønn AM, Curtis J, Duraisingh MT, Lemnge MM, Mhina J, Bygbjerg IC, Warhurst DC. High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance. Trop Med Int Health. 1997 Nov; 2(11):1075-9.
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  81. von Seidlein L, Duraisingh MT, Drakeley CJ, Bailey R, Greenwood BM, Pinder M. Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia. Trans R Soc Trop Med Hyg. 1997 Jul-Aug; 91(4):450-3.
    View in: PubMed
  82. Duraisingh MT, Drakeley CJ, Muller O, Bailey R, Snounou G, Targett GA, Greenwood BM, Warhurst DC. Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine. Parasitology. 1997 Mar; 114 ( Pt 3):205-11.
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  83. Curtis J, Duraisingh MT, Trigg JK, Mbwana H, Warhurst DC, Curtis CF. Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania. Trans R Soc Trop Med Hyg. 1996 Nov-Dec; 90(6):678-80.
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  84. Drakeley CJ, Duraisingh MT, Póvoa M, Conway DJ, Targett GA, Baker DA. Geographical distribution of a variant epitope of Pfs48/45, a Plasmodium falciparum transmission-blocking vaccine candidate. Mol Biochem Parasitol. 1996 Oct 30; 81(2):253-7.
    View in: PubMed
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Duraisingh's Networks
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Concepts
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Co-Authors
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Similar People
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Same Department