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Albert Edge, PH.D.

TitleAssociate Professor of Otology and Laryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtology and Laryngology
AddressMassachusetts Eye & Ear Infrm
Eaton Peabody Lab
243 Charles St
Boston MA 02114
Phone617/573-4452
Fax617/720-4408

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Shi F, Hu L, Edge AS. Generation of hair cells in neonatal mice by ß-catenin overexpression in Lgr5-positive cochlear progenitors. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13851-6.
    View in: PubMed
  2. Kao SY, Kempfle JS, Jensen JB, Perez-Fernandez D, Lysaght AC, Edge AS, Stankovic KM. Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss. Neurobiol Dis. 2013 Aug; 56:25-33.
    View in: PubMed
  3. Tong M, Brugeaud A, Edge AS. Regenerated synapses between postnatal hair cells and auditory neurons. J Assoc Res Otolaryngol. 2013 Jun; 14(3):321-9.
    View in: PubMed
  4. Shi F, Edge AS. Prospects for replacement of auditory neurons by stem cells. Hear Res. 2013 Mar; 297:106-12.
    View in: PubMed
  5. Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge AS. Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Neuron. 2013 Jan 9; 77(1):58-69.
    View in: PubMed
  6. Shi F, Kempfle JS, Edge AS. Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. J Neurosci. 2012 Jul 11; 32(28):9639-48.
    View in: PubMed
  7. Jeon SJ, Fujioka M, Kim SC, Edge AS. Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells. J Neurosci. 2011 Jun 8; 31(23):8351-8.
    View in: PubMed
  8. Fujioka M, Tokano H, Fujioka KS, Okano H, Edge AS. Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation. J Clin Invest. 2011 Jun; 121(6):2462-9.
    View in: PubMed
  9. Parker MA, Jiang K, Kempfle JS, Mizutari K, Simmons CL, Bieber R, Adams J, Edge AS. TAK1 expression in the cochlea: a specific marker for adult supporting cells. J Assoc Res Otolaryngol. 2011 Aug; 12(4):471-83.
    View in: PubMed
  10. Parker M, Brugeaud A, Edge AS. Primary culture and plasmid electroporation of the murine organ of Corti. J Vis Exp. 2010; (36).
    View in: PubMed
  11. Shi F, Cheng YF, Wang XL, Edge AS. Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhancer. J Biol Chem. 2010 Jan 1; 285(1):392-400.
    View in: PubMed
  12. Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. BMC Neurosci. 2009; 10:122.
    View in: PubMed
  13. Edge AS, Chen ZY. Hair cell regeneration. Curr Opin Neurobiol. 2008 Aug; 18(4):377-82.
    View in: PubMed
  14. Martinez-Monedero R, Yi E, Oshima K, Glowatzki E, Edge AS. Differentiation of inner ear stem cells to functional sensory neurons. Dev Neurobiol. 2008 Apr; 68(5):669-84.
    View in: PubMed
  15. Shi F, Corrales CE, Liberman MC, Edge AS. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. Eur J Neurosci. 2007 Dec; 26(11):3016-23.
    View in: PubMed
  16. Martinez-Monedero R, Oshima K, Heller S, Edge AS. The potential role of endogenous stem cells in regeneration of the inner ear. Hear Res. 2007 May; 227(1-2):48-52.
    View in: PubMed
  17. Martinez-Monedero R, Edge AS. Stem cells for the replacement of inner ear neurons and hair cells. Int J Dev Biol. 2007; 51(6-7):655-61.
    View in: PubMed
  18. Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. J Assoc Res Otolaryngol. 2007 Mar; 8(1):18-31.
    View in: PubMed
  19. Jeon SJ, Oshima K, Heller S, Edge AS. Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Mol Cell Neurosci. 2007 Jan; 34(1):59-68.
    View in: PubMed
  20. Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS. Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. J Neurobiol. 2006 Nov; 66(13):1489-500.
    View in: PubMed
  21. Huang L, Shimaoka M, Rondon IJ, Roy I, Chang Q, Po M, Dransfield DT, Ladner RC, Edge AS, Salas A, Wood CR, Springer TA, Cohen EH. Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1. J Leukoc Biol. 2006 Oct; 80(4):905-14.
    View in: PubMed
  22. Martinez-Monedero R, Corrales CE, Cuajungco MP, Heller S, Edge AS. Reinnervation of hair cells by auditory neurons after selective removal of spiral ganglion neurons. J Neurobiol. 2006 Mar; 66(4):319-31.
    View in: PubMed
  23. Li H, Corrales CE, Edge A, Heller S. Stem cells as therapy for hearing loss. Trends Mol Med. 2004 Jul; 10(7):309-15.
    View in: PubMed
  24. Crosby K, Yatko C, Dersimonian H, Pan L, Edge AS. A novel monoclonal antibody inhibits the immune response of human cells against porcine cells: identification of a porcine antigen homologous to CD58. Transplantation. 2004 Apr 27; 77(8):1288-94.
    View in: PubMed
  25. Edge AS. Deglycosylation of glycoproteins with trifluoromethanesulphonic acid: elucidation of molecular structure and function. Biochem J. 2003 Dec 1; 376(Pt 2):339-50.
    View in: PubMed
  26. Nagata H, Ito M, Shirota C, Edge A, McCowan TC, Fox IJ. Route of hepatocyte delivery affects hepatocyte engraftment in the spleen. Transplantation. 2003 Aug 27; 76(4):732-4.
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  27. Pagani FD, DerSimonian H, Zawadzka A, Wetzel K, Edge AS, Jacoby DB, Dinsmore JH, Wright S, Aretz TH, Eisen HJ, Aaronson KD. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol. 2003 Mar 5; 41(5):879-88.
    View in: PubMed
  28. Del Priore LV, Sheng Y, Johnson E, Jacoby D, Edge A, Suzuki T, Geng L, Tezel TH, Kaplan HJ. Identification of transplanted retinal pigment epithelium with a novel chromosomal marker. Curr Eye Res. 2003 Feb; 26(2):125-31.
    View in: PubMed
  29. Nagata H, Ito M, Cai J, Edge AS, Platt JL, Fox IJ. Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation. Gastroenterology. 2003 Feb; 124(2):422-31.
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  30. Nagata H, Ito M, Shirota C, Edge ASB, McCowan TC, Fox IJ. Transplantation. Route of hepatocyte delivery affects hepatocyte engraftment in the spleen. 2003; 76:732-734.
  31. Jain M, DerSimonian H, Brenner DA, Ngoy S, Teller P, Edge AS, Zawadzka A, Wetzel K, Sawyer DB, Colucci WS, Apstein CS, Liao R. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation. 2001 Apr 10; 103(14):1920-7.
    View in: PubMed
  32. Edge ASB. Graft. Xenotransplantation of neural cells. 2001; 4:118-119.
  33. Edge AS, Spiro RG. A specific structural alteration in the heparan sulphate of human glomerular basement membrane in diabetes. Diabetologia. 2000 Aug; 43(8):1056-9.
    View in: PubMed
  34. Edge AS. Current applications of cellular xenografts. Transplant Proc. 2000 Aug; 32(5):1169-71.
    View in: PubMed
  35. Stefan AM, Coulter S, Gray B, LaMorte W, Nikelaeson S, Edge AS, Afdhal NH. Xenogeneic transplantation of porcine hepatocytes into the CCl4 cirrhotic rat model. Cell Transplant. 1999 Nov-Dec; 8(6):649-59.
    View in: PubMed
  36. DerSimonian H, Pan L, Yatko C, Rodrigue-Way A, Johnson E, Edge AS. Human anti-porcine T cell response: blocking with anti-class I antibody leads to hyporesponsiveness and a switch in cytokine production. J Immunol. 1999 Jun 15; 162(12):6993-7001.
    View in: PubMed
  37. Edge AS, Gosse ME, Dinsmore J. Xenogeneic cell therapy: current progress and future developments in porcine cell transplantation. Cell Transplant. 1998 Nov-Dec; 7(6):525-39.
    View in: PubMed
  38. Sullivan JA, Oettinger HF, Sachs DH, Edge AS. Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes. J Immunol. 1997 Sep 1; 159(5):2318-26.
    View in: PubMed
  39. Edge AS, Spiro RG. Structure of the O-linked oligosaccharides from a major thyroid cell surface glycoprotein. Arch Biochem Biophys. 1997 Jul 1; 343(1):73-80.
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  40. Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med. 1997 Mar; 3(3):350-3.
    View in: PubMed
  41. Gunsalus JR, Coulter SM, Gray BM, Edge AS. Xenotransplantation for the treatment of hypercholesterolemia. Transplant Proc. 1997 Feb-Mar; 29(1-2):905-6.
    View in: PubMed
  42. Donnelly CE, Yatko C, Johnson EW, Edge AS. Human natural killer cells account for non-MHC class I-restricted cytolysis of porcine cells. Cell Immunol. 1997 Feb 1; 175(2):171-8.
    View in: PubMed
  43. Oettinger HF, Sullivan JA, Horvath KE, Kelley JA, Jacoby DB, Dinsmore J, Zawadska A, Edge ASB. Xenotransplantation. Species-specific detection of porcine xenografts with an antibody against a novel epitope of the lymphocyte homing receptor CD44. 1997; 4:252-261.
  44. Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge AS. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med. 1997 Jan; 3(1):48-53.
    View in: PubMed
  45. Edge ASB, DInsmore J. Xeno. Xenotransplantation in the central nervous system. 1997; 5:23-25.
  46. LaVecchio JA, Dunne AD, Edge AS. Enzymatic removal of alpha-galactosyl epitopes from porcine endothelial cells diminishes the cytotoxic effect of natural antibodies. Transplantation. 1995 Oct 27; 60(8):841-7.
    View in: PubMed
  47. Oettinger HF, Rodrigue-Way A, Bousquet JJ, Edge AS. Porcine repeat element DNA: in situ detection of xenotransplanted cells. Cell Transplant. 1995 Mar-Apr; 4(2):253-6.
    View in: PubMed
  48. Edge AS, Karasik A, Yamada K, Kahn CR. Effect of dexamethasone on the carbohydrate chains of the insulin receptor. Biochem Biophys Res Commun. 1994 Apr 29; 200(2):852-9.
    View in: PubMed
  49. Edge AS, Kahn CR, Spiro RG. Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains. Endocrinology. 1990 Oct; 127(4):1887-95.
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  50. Edge AS, Spiro RG. Characterization of novel sequences containing 3-O-sulfated glucosamine in glomerular basement membrane heparan sulfate and localization of sulfated disaccharides to a peripheral domain. J Biol Chem. 1990 Sep 15; 265(26):15874-81.
    View in: PubMed
  51. Edge AS, Spiro RG. Presence of an O-glycosidically linked hexasaccharide in fetuin. J Biol Chem. 1987 Nov 25; 262(33):16135-41.
    View in: PubMed
  52. Edge AS, Spiro RG. Selective deglycosylation of the heparan sulfate proteoglycan of bovine glomerular basement membrane and identification of the core protein. J Biol Chem. 1987 May 15; 262(14):6893-8.
    View in: PubMed
  53. Edge AS, Van Langenhove A, Reinhold V, Weber P. Characterization of O-glycosidically linked oligosaccharides of rat erythrocyte membrane sialoglycoproteins. Biochemistry. 1986 Dec 2; 25(24):8017-24.
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  54. Edge AS, Spiro RG. Thyroid cell surface glycoproteins. Nature and disposition of carbohydrate units and evaluation of their blood group I activity. J Biol Chem. 1985 Dec 5; 260(28):15332-8.
    View in: PubMed
  55. Edge AS, Spiro RG. Structural elucidation of glycosaminoglycans through characterization of disaccharides obtained after fragmentation by hydrazine-nitrous acid treatment. Arch Biochem Biophys. 1985 Aug 1; 240(2):560-72.
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  56. Herzberg VL, Grigorescu F, Edge AS, Spiro RG, Kahn CR. Characterization of insulin receptor carbohydrate by comparison of chemical and enzymatic deglycosylation. Biochem Biophys Res Commun. 1985 Jun 28; 129(3):789-96.
    View in: PubMed
  57. Edge AS, Spiro RG. Presence of sulfate in N-glycosidically linked carbohydrate units of calf thyroid plasma membrane glycoproteins. J Biol Chem. 1984 Apr 25; 259(8):4710-3.
    View in: PubMed
  58. Edge AS, Weber P. Isolation of sulfited oligosaccharides from glycoproteins treated with alkaline sulfite. Carbohydr Res. 1984 Mar 15; 126(2):279-85.
    View in: PubMed
  59. Edge AS, Faltynek CR, Hof L, Reichert LE, Weber P. Deglycosylation of glycoproteins by trifluoromethanesulfonic acid. Anal Biochem. 1981 Nov 15; 118(1):131-7.
    View in: PubMed
  60. Edge AS, Weber P. Purification and characterization of the major sialoglycoproteins of the rat erythrocyte membrane. Arch Biochem Biophys. 1981 Jul; 209(2):697-705.
    View in: PubMed
  61. Edge AS, Weber P. Cleavage of dehydroalanine-containing peptides with mercuric acetate. Int J Pept Protein Res. 1981 Jul; 18(1):1-5.
    View in: PubMed
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