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Jeffrey Lawrence Ecker, M.D.

TitleProfessor of Obstetrics, Gynecology and Reproductive Biology
InstitutionMassachusetts General Hospital
DepartmentObstetrics Gynecology & Repro. Bio.
AddressMassachusetts General Hospital
Ob/Gyn, Founders 431
55 Fruit St
Boston MA 02114
Phone617/724-9030
Fax617/726-4267

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ecker JL, MacGillivray TE, Fitzsimons MG. Case 40-2012: A woman with cardiorespiratory arrest after a cesarean section. N Engl J Med. 2013 Mar 28; 368(13):1261.
    View in: PubMed
  2. Cáceres IA, Arcaya M, Declercq E, Belanoff CM, Janakiraman V, Cohen B, Ecker J, Smith LA, Subramanian SV. Hospital Differences in Cesarean Deliveries in Massachusetts (US) 2004-2006: The Case against Case-Mix Artifact. PLoS One. 2013; 8(3):e57817.
    View in: PubMed
  3. Durfee SM, Benson CB, Adams SR, Ecker J, House M, Jennings R, Katz D, Pettigrew C, Wolfberg A. Postnatal outcome of fetuses with the prenatal diagnosis of gastroschisis. J Ultrasound Med. 2013 Mar; 32(3):407-12.
    View in: PubMed
  4. Young BC, Ecker JL. Fetal macrosomia and shoulder dystocia in women with gestational diabetes: risks amenable to treatment? Curr Diab Rep. 2013 Feb; 13(1):12-8.
    View in: PubMed
  5. Ecker JL, Solt K, Fitzsimons MG, MacGillivray TE. Case records of the Massachusetts General Hospital. Case 40-2012. A 43-year-old woman with cardiorespiratory arrest after a cesarean section. N Engl J Med. 2012 Dec 27; 367(26):2528-36.
    View in: PubMed
  6. Brown SD, Donelan K, Martins Y, Burmeister K, Buchmiller TL, Sayeed SA, Mitchell C, Ecker JL. Differing attitudes toward fetal care by pediatric and maternal-fetal medicine specialists. Pediatrics. 2012 Dec; 130(6):e1534-40.
    View in: PubMed
  7. Adams SR, Durfee S, Pettigrew C, Katz D, Jennings R, Ecker J, House M, Benson CB, Wolfberg A. Accuracy of sonography to predict estimated weight in fetuses with gastroschisis. J Ultrasound Med. 2012 Nov; 31(11):1753-8.
    View in: PubMed
  8. York-Best CM, Ecker JL. Pelvic examinations under anesthesia: a teachable moment. Obstet Gynecol. 2012 Oct; 120(4):741-2.
    View in: PubMed
  9. Bateman BT, Hernandez-Diaz S, Huybrechts KF, Palmsten K, Mogun H, Ecker JL, Fischer MA. Patterns of outpatient antihypertensive medication use during pregnancy in a Medicaid population. Hypertension. 2012 Oct; 60(4):913-20.
    View in: PubMed
  10. Minkoff H, Ecker J. When legislators play doctor: the ethics of mandatory preabortion ultrasound examinations. Obstet Gynecol. 2012 Sep; 120(3):647-9.
    View in: PubMed
  11. Scholl J, Durfee SM, Russell MA, Heard AJ, Iyer C, Alammari R, Coletta J, Craigo SD, Fuchs KM, D'Alton M, House M, Jennings RW, Ecker J, Panda B, Tanner C, Wolfberg A, Benson CB. First-trimester cystic hygroma: relationship of nuchal translucency thickness and outcomes. Obstet Gynecol. 2012 Sep; 120(3):551-9.
    View in: PubMed
  12. Panda B, Panda A, Ueda I, Abrahams VM, Norwitz ER, Stanic AK, Young BC, Ecker JL, Altfeld M, Shaw AC, Rueda BR. Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors. J Reprod Immunol. 2012 Jun; 94(2):210-5.
    View in: PubMed
  13. Brown SD, Ecker JL, Ward JR, Halpern EF, Sayeed SA, Buchmiller TL, Mitchell C, Donelan K. Prenatally diagnosed fetal conditions in the age of fetal care: does who counsels matter? Am J Obstet Gynecol. 2012 May; 206(5):409.e1-11.
    View in: PubMed
  14. Osborne C, Ecker JL, Gauvreau K, Lieberman E. First birth cesarean and risk of antepartum fetal death in a subsequent pregnancy. J Midwifery Womens Health. 2012 Jan-Feb; 57(1):12-7.
    View in: PubMed
  15. Abrams JL, Ecker JL, Barth WH. Case 23-2011--Legal considerations. N Engl J Med. 2011 Nov 10; 365(19):1846-7.
    View in: PubMed
  16. Osborne C, Ecker JL, Gauvreau K, Davidson KM, Lieberman E. Maternal temperature elevation and occiput posterior position at birth among low-risk women receiving epidural analgesia. J Midwifery Womens Health. 2011 Sep; 56(5):446-51.
    View in: PubMed
  17. Seely EW, Ecker J. Clinical practice. Chronic hypertension in pregnancy. N Engl J Med. 2011 Aug 4; 365(5):439-46.
    View in: PubMed
  18. Barth WH, Kwolek CJ, Abrams JL, Ecker JL, Roberts DJ. Case records of the Massachusetts General Hospital. Case 23-2011. A 40-year-old pregnant woman with placenta accreta who declined blood products. N Engl J Med. 2011 Jul 28; 365(4):359-66.
    View in: PubMed
  19. Ecker J, Minkoff H. Home birth: what are physicians' ethical obligations when patient choices may carry increased risk? Obstet Gynecol. 2011 May; 117(5):1179-82.
    View in: PubMed
  20. Shalowitz DI, Ecker JL. Research in pregnancy: back to first principles. Am J Bioeth. 2011 May; 11(5):56-7.
    View in: PubMed
  21. Paris AE, Greenberg JA, Ecker JL, McElrath TF. Is an episiotomy necessary with a shoulder dystocia? Am J Obstet Gynecol. 2011 Sep; 205(3):217.e1-3.
    View in: PubMed
  22. Powe CE, Ecker J, Rana S, Wang A, Ankers E, Ye J, Levine RJ, Karumanchi SA, Thadhani R. Preeclampsia and the risk of large-for-gestational-age infants. Am J Obstet Gynecol. 2011 May; 204(5):425.e1-6.
    View in: PubMed
  23. Tracy EE, Leffert LR, Clark VL, Ecker J. Regulatory and electronic alphabet soup: practice improvements and implications for providers. Technol Health Care. 2011; 19(5):341-7.
    View in: PubMed
  24. Nguyen US, Rothman KJ, Demissie S, Jackson DJ, Lang JM, Ecker JL. Epidural analgesia and risks of cesarean and operative vaginal deliveries in nulliparous and multiparous women. Matern Child Health J. 2010 Sep; 14(5):705-12.
    View in: PubMed
  25. Janakiraman V, Ecker J, Kaimal AJ. Comparing the second stage in induced and spontaneous labor. Obstet Gynecol. 2010 Sep; 116(3):606-11.
    View in: PubMed
  26. Minkoff H, Ecker J. Is there a doctor in the house? Standards of physician availability for laboring women. Obstet Gynecol. 2010 Sep; 116(3):723-7.
    View in: PubMed
  27. Janakiraman V, Ecker J. Quality in obstetric care: measuring what matters. Obstet Gynecol. 2010 Sep; 116(3):728-32.
    View in: PubMed
  28. Powe CE, Seely EW, Rana S, Bhan I, Ecker J, Karumanchi SA, Thadhani R. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension. 2010 Oct; 56(4):758-63.
    View in: PubMed
  29. Quaye AA, Raskin KA, Ecker JL, Leffert LR. Management of a parturient with high-grade osteosarcoma of the proximal femur: a multidisciplinary approach. Int J Obstet Anesth. 2010 Jul; 19(3):340-2.
    View in: PubMed
  30. Stuebe A, Ecker J, Bates DW, Zera C, Bentley-Lewis R, Seely E. Barriers to follow-up for women with a history of gestational diabetes. Am J Perinatol. 2010 Oct; 27(9):705-10.
    View in: PubMed
  31. Steinberg G, Lee C, Rauh-Hain JA, Ecker J, Khankin EV, Hsu CD, Cohen B, Rana S, Karumanchi SA, Thadhani R, Hacker MR, Lim KH. Early-pregnancy soluble Fas levels in idiopathic small-for-gestational-age pregnancies. Am J Obstet Gynecol. 2010 Mar; 202(3):299.e1-7.
    View in: PubMed
  32. Little SE, Janakiraman V, Kaimal A, Musci T, Ecker J, Caughey AB. The cost-effectiveness of prenatal screening for spinal muscular atrophy. Am J Obstet Gynecol. 2010 Mar; 202(3):253.e1-7.
    View in: PubMed
  33. Thadhani R, Powe CE, Tjoa ML, Khankin E, Ye J, Ecker J, Schneyer A, Karumanchi SA. First-trimester follistatin-like-3 levels in pregnancies complicated by subsequent gestational diabetes mellitus. Diabetes Care. 2010 Mar; 33(3):664-9.
    View in: PubMed
  34. Minkoff H, Ecker J. The California octuplets and the duties of reproductive endocrinologists. Am J Obstet Gynecol. 2009 Jul; 201(1):15.e1-3.
    View in: PubMed
  35. Rauh-Hain JA, Rana S, Tamez H, Wang A, Cohen B, Cohen A, Brown F, Ecker JL, Karumanchi SA, Thadhani R. Risk for developing gestational diabetes in women with twin pregnancies. J Matern Fetal Neonatal Med. 2009 Apr; 22(4):293-9.
    View in: PubMed
  36. Nguyen US, Rothman KJ, Demissie S, Jackson DJ, Lang JM, Ecker JL. Transfers among women intending a birth center delivery in the San Diego birth center study. J Midwifery Womens Health. 2009 Mar-Apr; 54(2):104-10.
    View in: PubMed
  37. Stuebe AM, McElrath TF, Thadhani R, Ecker JL. Second trimester insulin resistance, early pregnancy body mass index and gestational weight gain. Matern Child Health J. 2010 Mar; 14(2):254-60.
    View in: PubMed
  38. Ecker JL. Gestational diabetes: an opportunity for improvement. J Clin Endocrinol Metab. 2008 Dec; 93(12):4646-7.
    View in: PubMed
  39. Ecker JL, Greene MF. Gestational diabetes--setting limits, exploring treatments. N Engl J Med. 2008 May 8; 358(19):2061-3.
    View in: PubMed
  40. Minkoff H, Ecker J. Genetic testing and breach of patient confidentiality: law, ethics, and pragmatics. Am J Obstet Gynecol. 2008 May; 198(5):498.e1-4.
    View in: PubMed
  41. Zhang L, Kanda Y, Roberts DJ, Ecker JL, Losel R, Wehling M, Peluso JJ, Pru JK. Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human. Mol Cell Endocrinol. 2008 Jun 11; 287(1-2):81-9.
    View in: PubMed
  42. Ecker JL, O'Rourke PP. An immodest proposal: banking embryonic stem cells for solid organ transplantation is problematic and premature. Am J Bioeth. 2007 Aug; 7(8):48-50; discussion W4-6.
    View in: PubMed
  43. Smirnakis KV, Plati A, Wolf M, Thadhani R, Ecker JL. Predicting gestational diabetes: choosing the optimal early serum marker. Am J Obstet Gynecol. 2007 Apr; 196(4):410.e1-6; discussion 410.e6-7.
    View in: PubMed
  44. Ecker JL, Frigoletto FD. Cesarean delivery and the risk-benefit calculus. N Engl J Med. 2007 Mar 1; 356(9):885-8.
    View in: PubMed
  45. Brown SD, Truog RD, Johnson JA, Ecker JL. Do differences in the American Academy of Pediatrics and the American College of Obstetricians and Gynecologists positions on the ethics of maternal-fetal interventions reflect subtly divergent professional sensitivities to pregnant women and fetuses? Pediatrics. 2006 Apr; 117(4):1382-7.
    View in: PubMed
  46. Williams WW, Ecker JL, Thadhani RI, Rahemtullah A. Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension. N Engl J Med. 2005 Dec 15; 353(24):2590-600.
    View in: PubMed
  47. Smirnakis KV, Chasan-Taber L, Wolf M, Markenson G, Ecker JL, Thadhani R. Postpartum diabetes screening in women with a history of gestational diabetes. Obstet Gynecol. 2005 Dec; 106(6):1297-303.
    View in: PubMed
  48. Wolf M, Shah A, Lam C, Martinez A, Smirnakis KV, Epstein FH, Taylor RN, Ecker JL, Karumanchi SA, Thadhani R. Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies. Am J Obstet Gynecol. 2005 Jul; 193(1):16-22.
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  49. Ecker JL, Greene MF. The case against private umbilical cord blood banking. Obstet Gynecol. 2005 Jun; 105(6):1282-4.
    View in: PubMed
  50. Smirnakis KV, Martinez A, Blatman KH, Wolf M, Ecker JL, Thadhani R. Early pregnancy insulin resistance and subsequent gestational diabetes mellitus. Diabetes Care. 2005 May; 28(5):1207-8.
    View in: PubMed
  51. Wolf M, Hubel CA, Lam C, Sampson M, Ecker JL, Ness RB, Rajakumar A, Daftary A, Shakir AS, Seely EW, Roberts JM, Sukhatme VP, Karumanchi SA, Thadhani R. Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance. J Clin Endocrinol Metab. 2004 Dec; 89(12):6239-43.
    View in: PubMed
  52. Falk SJ, Campbell LJ, Lee-Parritz A, Cohen AP, Ecker J, Wilkins-Haug L, Lieberman E. Expectant management in spontaneous preterm premature rupture of membranes between 14 and 24 weeks' gestation. J Perinatol. 2004 Oct; 24(10):611-6.
    View in: PubMed
  53. Greenberg JA, Lieberman E, Cohen AP, Ecker JL. Randomized comparison of chromic versus fast-absorbing polyglactin 910 for postpartum perineal repair. Obstet Gynecol. 2004 Jun; 103(6):1308-13.
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  54. Ecker JL. Cesarean delivery for suspected macrosomia: inefficient at best. Clin Obstet Gynecol. 2004 Jun; 47(2):352-64.
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  55. Wolf M, Shah A, Jimenez-Kimble R, Sauk J, Ecker JL, Thadhani R. Differential risk of hypertensive disorders of pregnancy among Hispanic women. J Am Soc Nephrol. 2004 May; 15(5):1330-8.
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  56. Thadhani R, Ecker JL, Mutter WP, Wolf M, Smirnakis KV, Sukhatme VP, Levine RJ, Karumanchi SA. Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia. Hypertension. 2004 May; 43(5):988-92.
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  57. Thadhani R, Mutter WP, Wolf M, Levine RJ, Taylor RN, Sukhatme VP, Ecker J, Karumanchi SA. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab. 2004 Feb; 89(2):770-5.
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  58. Ecker JL. Once a pregnancy, always a cesarean? Rationale and feasibility of a randomized controlled trial. Am J Obstet Gynecol. 2004 Feb; 190(2):314-8.
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  59. Greene MF, Ecker JL. Abortion, health, and the law. N Engl J Med. 2004 Jan 8; 350(2):184-6.
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  60. Wolf M, Sauk J, Shah A, Vossen Smirnakis K, Jimenez-Kimble R, Ecker JL, Thadhani R. Inflammation and glucose intolerance: a prospective study of gestational diabetes mellitus. Diabetes Care. 2004 Jan; 27(1):21-7.
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  61. Styer AK, Parker HJ, Roberts DJ, Palmer-Toy D, Toth TL, Ecker JL. Placental villitis of unclear etiology during ovum donor in vitro fertilization pregnancy. Am J Obstet Gynecol. 2003 Oct; 189(4):1184-6.
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  62. Thadhani R, Wolf M, Hsu-Blatman K, Sandler L, Nathan D, Ecker JL. First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus. Am J Obstet Gynecol. 2003 Jul; 189(1):171-6.
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  63. Riley L, Appollon K, Haider S, Chan-Flynn S, Cohen A, Ecker J, Rein M, Lieberman E. "Real World" compliance with strategies to prevent early-onset group B streptococcal disease. J Perinatol. 2003 Jun; 23(4):272-7.
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  64. Jackson DJ, Lang JM, Swartz WH, Ganiats TG, Fullerton J, Ecker J, Nguyen U. Outcomes, safety, and resource utilization in a collaborative care birth center program compared with traditional physician-based perinatal care. Am J Public Health. 2003 Jun; 93(6):999-1006.
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  65. Smith-Bindman R, Chu PW, Ecker J, Feldstein VA, Filly RA, Bacchetti P. Adverse birth outcomes in relation to prenatal sonographic measurements of fetal size. J Ultrasound Med. 2003 Apr; 22(4):347-56; quiz 357-8.
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  66. Jackson DJ, Lang JM, Ecker J, Swartz WH, Heeren T. Impact of collaborative management and early admission in labor on method of delivery. J Obstet Gynecol Neonatal Nurs. 2003 Mar-Apr; 32(2):147-57; discussion 158-60.
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  67. Wolf M, Sandler L, Hsu K, Vossen-Smirnakis K, Ecker JL, Thadhani R. First-trimester C-reactive protein and subsequent gestational diabetes. Diabetes Care. 2003 Mar; 26(3):819-24.
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  68. Wolf M, Sandler L, Jimenez-Kimble R, Shah A, Ecker JL, Thadhani R. Insulin resistance but not inflammation is associated with gestational hypertension. Hypertension. 2002 Dec; 40(6):886-91.
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  69. Wu J, Viguera A, Riley L, Cohen L, Ecker J. Mood disturbance in pregnancy and the mode of delivery. Am J Obstet Gynecol. 2002 Oct; 187(4):864-7.
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  70. Smith-Bindman R, Chu PW, Ecker JL, Feldstein VA, Filly RA, Bacchetti P. US evaluation of fetal growth: prediction of neonatal outcomes. Radiology. 2002 Apr; 223(1):153-61.
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  71. Wolf M, Sandler L, Muñoz K, Hsu K, Ecker JL, Thadhani R. First trimester insulin resistance and subsequent preeclampsia: a prospective study. J Clin Endocrinol Metab. 2002 Apr; 87(4):1563-8.
    View in: PubMed
  72. Wolf M, Kettyle E, Sandler L, Ecker JL, Roberts J, Thadhani R. Obesity and preeclampsia: the potential role of inflammation. Obstet Gynecol. 2001 Nov; 98(5 Pt 1):757-62.
    View in: PubMed
  73. Ecker JL, Chen KT, Cohen AP, Riley LE, Lieberman ES. Increased risk of cesarean delivery with advancing maternal age: indications and associated factors in nulliparous women. Am J Obstet Gynecol. 2001 Oct; 185(4):883-7.
    View in: PubMed
  74. Thadhani R, Ecker JL, Kettyle E, Sandler L, Frigoletto FD. Pulse pressure and risk of preeclampsia: a prospective study. Obstet Gynecol. 2001 Apr; 97(4):515-20.
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  75. McElrath TF, Robinson JN, Ecker JL, Ringer SA, Norwitz ER. Neonatal outcome of infants born at 23 weeks' gestation. Obstet Gynecol. 2001 Jan; 97(1):49-52.
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  76. Ecker JL, Shipp TD, Bromley B, Benacerraf B. The sonographic diagnosis of Dandy-Walker and Dandy-Walker variant: associated findings and outcomes. Prenat Diagn. 2000 Apr; 20(4):328-32.
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  77. Ecker JL, Mascola MA, Riley LE. Gestational diabetes. N Engl J Med. 2000 Mar 23; 342(12):896-7.
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  78. Ecker JL, Parer JT. Obstetric evaluation of fetal acid-base balance. Crit Rev Clin Lab Sci. 1999 Oct; 36(5):407-51.
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  79. Ecker JL, Frigoletto FD. Routine ultrasound screening in low-risk pregnancies: imperatives for further study. Obstet Gynecol. 1999 Apr; 93(4):607-10.
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  80. Lim KH, Friedman SA, Ecker JL, Kao L, Kilpatrick SJ. The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. Am J Obstet Gynecol. 1998 May; 178(5):1067-71.
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  81. Ecker JL, Filly RA, Zaloudek C, Wright RR, Drexler B, Goldberg JD. Chorionicity inaccurately predicted by early ultrasound: a case report. Prenat Diagn. 1998 May; 18(5):485-9.
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  82. Ecker JL, Musci TJ. Treatment of thyroid disease in pregnancy. Obstet Gynecol Clin North Am. 1997 Sep; 24(3):575-89.
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  83. Bansal RK, Goldsmith PC, He Y, Zaloudek CJ, Ecker JL, Riemer RK. A decline in myometrial nitric oxide synthase expression is associated with labor and delivery. J Clin Invest. 1997 May 15; 99(10):2502-8.
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  84. Ecker JL, Greenberg JA, Norwitz ER, Nadel AS, Repke JT. Birth weight as a predictor of brachial plexus injury. Obstet Gynecol. 1997 May; 89(5 Pt 1):643-7.
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  85. Ecker JL, Tan WM, Bansal RK, Bishop JT, Kilpatrick SJ. Is there a benefit to episiotomy at operative vaginal delivery? Observations over ten years in a stable population. Am J Obstet Gynecol. 1997 Feb; 176(2):411-4.
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  86. Ecker JL, Kilpatrick SJ. Prelabor rupture of the membranes at term. N Engl J Med. 1996 Oct 10; 335(15):1157-8.
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  87. Bansal RK, Tan WM, Ecker JL, Bishop JT, Kilpatrick SJ. Is there a benefit to episiotomy at spontaneous vaginal delivery? A natural experiment. Am J Obstet Gynecol. 1996 Oct; 175(4 Pt 1):897-901.
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  88. Bansal RK, Ecker JL, Laros RK. Blood glucose monitoring in gestational diabetes mellitus. N Engl J Med. 1996 Feb 29; 334(9):598; author reply 599.
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  89. Ecker JL. The cost-effectiveness of human immunodeficiency virus screening in pregnancy. Am J Obstet Gynecol. 1996 Feb; 174(2):716-21.
    View in: PubMed
  90. Ecker JL. Mandatory disclosure of human immunodeficiency virus status by surgeons is philosophically and practically counterproductive. Am J Obstet Gynecol. 1995 May; 172(5):1647.
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  91. Laufer MR, Ecker JL, Hill JA. Pregnancy outcome following ultrasound-detected fetal cardiac activity in women with a history of multiple spontaneous abortions. J Soc Gynecol Investig. 1994 Apr-Jun; 1(2):138-42.
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  92. Ecker JL, Laufer MR, Hill JA. Measurement of embryotoxic factors is predictive of pregnancy outcome in women with a history of recurrent abortion. Obstet Gynecol. 1993 Jan; 81(1):84-7.
    View in: PubMed
  93. Ecker JL, Sorem KA, Soodak L, Roberts DJ, Safon LE, Osathanondh R. Placenta increta complicating a first-trimester abortion. A case report. J Reprod Med. 1992 Oct; 37(10):893-5.
    View in: PubMed
  94. Ryan ET, Ecker JL, Christakis NA, Folkman J. Hirschsprung's disease: associated abnormalities and demography. J Pediatr Surg. 1992 Jan; 27(1):76-81.
    View in: PubMed
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