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Stephen Lory, Ph.D.

TitleProfessor of Microbiology and Immunobiology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Medical School
MBIB, Room 1038 A
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-5099

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB. Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20747-52.
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  2. Skurnik D, Roux D, Aschard H, Cattoir V, Yoder-Himes D, Lory S, Pier GB. A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries. PLoS Pathog. 2013 Sep; 9(9):e1003582.
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  3. Cattoir V, Narasimhan G, Skurnik D, Aschard H, Roux D, Ramphal R, Jyot J, Lory S. Transcriptional Response of Mucoid Pseudomonas aeruginosa to Human Respiratory Mucus. MBio. 2013; 3(6).
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  4. Wurtzel O, Yoder-Himes DR, Han K, Dandekar AA, Edelheit S, Greenberg EP, Sorek R, Lory S. The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature. PLoS Pathog. 2012 Sep; 8(9):e1002945.
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  5. Wu W, Huang J, Duan B, Traficante DC, Hong H, Risech M, Lory S, Priebe GP. Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2012 Sep 1; 186(5):420-7.
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  6. Balasubramanian D, Schneper L, Merighi M, Smith R, Narasimhan G, Lory S, Mathee K. The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes. PLoS One. 2012; 7(3):e34067.
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  7. Hoang HH, Nickerson NN, Lee VT, Kazimirova A, Chami M, Pugsley AP, Lory S. Outer membrane targeting of Pseudomonas aeruginosa proteins shows variable dependence on the components of Bam and Lol machineries. MBio. 2011; 2(6).
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  8. Archuleta TL, Du Y, English CA, Lory S, Lesser C, Ohi MD, Ohi R, Spiller BW. The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly. J Biol Chem. 2011 Sep 30; 286(39):33992-8.
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  9. Koh AY, Mikkelsen PJ, Smith RS, Coggshall KT, Kamei A, Givskov M, Lory S, Pier GB. Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination. PLoS One. 2010; 5(12):e15131.
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  10. Mulcahy LR, Burns JL, Lory S, Lewis K. Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J Bacteriol. 2010 Dec; 192(23):6191-9.
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  11. Guss AM, Roeselers G, Newton IL, Young CR, Klepac-Ceraj V, Lory S, Cavanaugh CM. Phylogenetic and metabolic diversity of bacteria associated with cystic fibrosis. ISME J. 2011 Jan; 5(1):20-9.
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  12. Carter MQ, Chen J, Lory S. The Pseudomonas aeruginosa pathogenicity island PAPI-1 is transferred via a novel type IV pilus. J Bacteriol. 2010 Jul; 192(13):3249-58.
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  13. Thaden JT, Lory S, Gardner TS. Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa. J Bacteriol. 2010 May; 192(10):2557-68.
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  14. Klepac-Ceraj V, Lemon KP, Martin TR, Allgaier M, Kembel SW, Knapp AA, Lory S, Brodie EL, Lynch SV, Bohannan BJ, Green JL, Maurer BA, Kolter R. Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa. Environ Microbiol. 2010 May; 12(5):1293-303.
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  15. Aiello D, Williams JD, Majgier-Baranowska H, Patel I, Peet NP, Huang J, Lory S, Bowlin TL, Moir DT. Discovery and characterization of inhibitors of Pseudomonas aeruginosa type III secretion. Antimicrob Agents Chemother. 2010 May; 54(5):1988-99.
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  16. Kamei A, Koh AY, Gadjeva M, Priebe GP, Lory S, Pier GB. Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model. J Infect Dis. 2010 Jan 1; 201(1):71-80.
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  17. Hurley BP, Goodman AL, Mumy KL, Murphy P, Lory S, McCormick BA. The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells. Microbes Infect. 2010 Mar; 12(3):190-8.
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  18. Montor WR, Huang J, Hu Y, Hainsworth E, Lynch S, Kronish JW, Ordonez CL, Logvinenko T, Lory S, LaBaer J. Genome-wide study of Pseudomonas aeruginosa outer membrane protein immunogenicity using self-assembling protein microarrays. Infect Immun. 2009 Nov; 77(11):4877-86.
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  19. Qiu X, Kulasekara BR, Lory S. Role of Horizontal Gene Transfer in the Evolution of Pseudomonas aeruginosa Virulence. Genome Dyn. 2009; 6:126-39.
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  20. Brencic A, McFarland KA, McManus HR, Castang S, Mogno I, Dove SL, Lory S. The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. Mol Microbiol. 2009 Aug; 73(3):434-45.
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  21. Brencic A, Lory S. Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA. Mol Microbiol. 2009 May; 72(3):612-32.
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  22. Goodman AL, Merighi M, Hyodo M, Ventre I, Filloux A, Lory S. Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen. Genes Dev. 2009 Jan 15; 23(2):249-59.
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  23. Lory S, Merighi M, Hyodo M. Multiple activities of c-di-GMP in Pseudomonas aeruginosa. Nucleic Acids Symp Ser (Oxf). 2009; (53):51-2.
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  24. Huang J, Lesser CF, Lory S. The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth. Nature. 2008 Nov 6; 456(7218):112-5.
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  25. Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Merrill RA, Lory S, Stagljar I. Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. PLoS Genet. 2008 Feb; 4(2):e1000005.
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  26. Mathee K, Narasimhan G, Valdes C, Qiu X, Matewish JM, Koehrsen M, Rokas A, Yandava CN, Engels R, Zeng E, Olavarietta R, Doud M, Smith RS, Montgomery P, White JR, Godfrey PA, Kodira C, Birren B, Galagan JE, Lory S. Dynamics of Pseudomonas aeruginosa genome evolution. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3100-5.
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  27. Lee VT, Matewish JM, Kessler JL, Hyodo M, Hayakawa Y, Lory S. A cyclic-di-GMP receptor required for bacterial exopolysaccharide production. Mol Microbiol. 2007 Sep; 65(6):1474-84.
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  28. Merighi M, Lee VT, Hyodo M, Hayakawa Y, Lory S. The second messenger bis-(3'-5')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa. Mol Microbiol. 2007 Aug; 65(4):876-95.
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  29. Ou HY, He X, Harrison EM, Kulasekara BR, Thani AB, Kadioglu A, Lory S, Hinton JC, Barer MR, Deng Z, Rajakumar K. MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands. Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W97-W104.
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  30. Lee VT, Pukatzki S, Sato H, Kikawada E, Kazimirova AA, Huang J, Li X, Arm JP, Frank DW, Lory S. Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU. Infect Immun. 2007 Mar; 75(3):1089-98.
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  31. Qiu X, Gurkar AU, Lory S. Interstrain transfer of the large pathogenicity island (PAPI-1) of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19830-5.
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  32. Linhartova I, Basler M, Ichikawa J, Pelicic V, Osicka R, Lory S, Nassif X, Sebo P. Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells. FEMS Microbiol Lett. 2006 Oct; 263(1):109-18.
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  33. Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ. A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science. 2006 Jun 9; 312(5779):1526-30.
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  34. Kulasekara BR, Kulasekara HD, Wolfgang MC, Stevens L, Frank DW, Lory S. Acquisition and evolution of the exoU locus in Pseudomonas aeruginosa. J Bacteriol. 2006 Jun; 188(11):4037-50.
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  35. Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S. Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2839-44.
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  36. Livny J, Brencic A, Lory S, Waldor MK. Identification of 17 Pseudomonas aeruginosa sRNAs and prediction of sRNA-encoding genes in 10 diverse pathogens using the bioinformatic tool sRNAPredict2. Nucleic Acids Res. 2006; 34(12):3484-93.
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  37. Ventre I, Goodman AL, Vallet-Gely I, Vasseur P, Soscia C, Molin S, Bleves S, Lazdunski A, Lory S, Filloux A. Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes. Proc Natl Acad Sci U S A. 2006 Jan 3; 103(1):171-6.
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  38. Ichikawa JK, English SB, Wolfgang MC, Jackson R, Butte AJ, Lory S. Genome-wide analysis of host responses to the Pseudomonas aeruginosa type III secretion system yields synergistic effects. Cell Microbiol. 2005 Nov; 7(11):1635-46.
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  39. Arora SK, Neely AN, Blair B, Lory S, Ramphal R. Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections. Infect Immun. 2005 Jul; 73(7):4395-8.
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  40. Lewis DA, Jones A, Parkhill J, Speert DP, Govan JR, Lipuma JJ, Lory S, Webb AK, Mahenthiralingam E. Identification of DNA markers for a transmissible Pseudomonas aeruginosa cystic fibrosis strain. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):56-64.
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  41. Lee VT, Smith RS, Tümmler B, Lory S. Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection. Infect Immun. 2005 Mar; 73(3):1695-705.
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  42. Kulasekara HD, Ventre I, Kulasekara BR, Lazdunski A, Filloux A, Lory S. A novel two-component system controls the expression of Pseudomonas aeruginosa fimbrial cup genes. Mol Microbiol. 2005 Jan; 55(2):368-80.
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  43. Lhoste EF, Gloux K, De Waziers I, Garrido S, Lory S, Philippe C, Rabot S, Knasmüller S. The activities of several detoxication enzymes are differentially induced by juices of garden cress, water cress and mustard in human HepG2 cells. Chem Biol Interact. 2004 Dec 7; 150(3):211-9.
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  44. Goodman AL, Kulasekara B, Rietsch A, Boyd D, Smith RS, Lory S. A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev Cell. 2004 Nov; 7(5):745-54.
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  45. Labaer J, Qiu Q, Anumanthan A, Mar W, Zuo D, Murthy TV, Taycher H, Halleck A, Hainsworth E, Lory S, Brizuela L. The Pseudomonas aeruginosa PA01 gene collection. Genome Res. 2004 Oct; 14(10B):2190-200.
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  46. Vallet I, Diggle SP, Stacey RE, Cámara M, Ventre I, Lory S, Lazdunski A, Williams P, Filloux A. Biofilm formation in Pseudomonas aeruginosa: fimbrial cup gene clusters are controlled by the transcriptional regulator MvaT. J Bacteriol. 2004 May; 186(9):2880-90.
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  47. Wolfgang MC, Jyot J, Goodman AL, Ramphal R, Lory S. Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6664-8.
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  48. Arora SK, Wolfgang MC, Lory S, Ramphal R. Sequence polymorphism in the glycosylation island and flagellins of Pseudomonas aeruginosa. J Bacteriol. 2004 Apr; 186(7):2115-22.
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  49. Lory S, Wolfgang M, Lee V, Smith R. The multi-talented bacterial adenylate cyclases. Int J Med Microbiol. 2004 Apr; 293(7-8):479-82.
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  50. Smith RS, Wolfgang MC, Lory S. An adenylate cyclase-controlled signaling network regulates Pseudomonas aeruginosa virulence in a mouse model of acute pneumonia. Infect Immun. 2004 Mar; 72(3):1677-84.
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  51. Goodman AL, Lory S. Analysis of regulatory networks in Pseudomonas aeruginosa by genomewide transcriptional profiling. Curr Opin Microbiol. 2004 Feb; 7(1):39-44.
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  52. Hybiske K, Ichikawa JK, Huang V, Lory SJ, Machen TE. Cystic fibrosis airway epithelial cell polarity and bacterial flagellin determine host response to Pseudomonas aeruginosa. Cell Microbiol. 2004 Jan; 6(1):49-63.
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  53. Ernst RK, D'Argenio DA, Ichikawa JK, Bangera MG, Selgrade S, Burns JL, Hiatt P, McCoy K, Brittnacher M, Kas A, Spencer DH, Olson MV, Ramsey BW, Lory S, Miller SI. Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis. Environ Microbiol. 2003 Dec; 5(12):1341-9.
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  54. Dasgupta N, Wolfgang MC, Goodman AL, Arora SK, Jyot J, Lory S, Ramphal R. A four-tiered transcriptional regulatory circuit controls flagellar biogenesis in Pseudomonas aeruginosa. Mol Microbiol. 2003 Nov; 50(3):809-24.
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  55. Wolfgang MC, Kulasekara BR, Liang X, Boyd D, Wu K, Yang Q, Miyada CG, Lory S. Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8484-9.
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  56. Wolfgang MC, Lee VT, Gilmore ME, Lory S. Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway. Dev Cell. 2003 Feb; 4(2):253-63.
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  57. Sundin C, Wolfgang MC, Lory S, Forsberg A, Frithz-Lindsten E. Type IV pili are not specifically required for contact dependent translocation of exoenzymes by Pseudomonas aeruginosa. Microb Pathog. 2002 Dec; 33(6):265-77.
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  58. Lory S, Ichikawa JK. Pseudomonas-epithelial cell interactions dissected with DNA microarrays. Chest. 2002 Mar; 121(3 Suppl):36S-39S.
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  59. Sokurenko EV, Tchesnokova V, Yeung AT, Oleykowski CA, Trintchina E, Hughes KT, Rashid RA, Brint JM, Moseley SL, Lory S. Detection of simple mutations and polymorphisms in large genomic regions. Nucleic Acids Res. 2001 Nov 15; 29(22):E111.
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  60. Whiteley M, Bangera MG, Bumgarner RE, Parsek MR, Teitzel GM, Lory S, Greenberg EP. Gene expression in Pseudomonas aeruginosa biofilms. Nature. 2001 Oct 25; 413(6858):860-4.
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  61. Arora SK, Bangera M, Lory S, Ramphal R. A genomic island in Pseudomonas aeruginosa carries the determinants of flagellin glycosylation. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9342-7.
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  62. Vallet I, Olson JW, Lory S, Lazdunski A, Filloux A. The chaperone/usher pathways of Pseudomonas aeruginosa: identification of fimbrial gene clusters (cup) and their involvement in biofilm formation. Proc Natl Acad Sci U S A. 2001 Jun 5; 98(12):6911-6.
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  63. Cohn LA, Weber A, Phillips T, Lory S, Kaplan M, Smith A. Pseudomonas aeruginosa infection of respiratory epithelium in a cystic fibrosis xenograft model. J Infect Dis. 2001 Mar 15; 183(6):919-27.
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  64. Liang X, Pham XQ, Olson MV, Lory S. Identification of a genomic island present in the majority of pathogenic isolates of Pseudomonas aeruginosa. J Bacteriol. 2001 Feb; 183(3):843-53.
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  65. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31; 406(6799):959-64.
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  66. Ichikawa JK, Norris A, Bangera MG, Geiss GK, van 't Wout AB, Bumgarner RE, Lory S. Interaction of pseudomonas aeruginosa with epithelial cells: identification of differentially regulated genes by expression microarray analysis of human cDNAs. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9659-64.
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  67. Arora SK, Dasgupta N, Lory S, Ramphal R. Identification of two distinct types of flagellar cap proteins, FliD, in Pseudomonas aeruginosa. Infect Immun. 2000 Mar; 68(3):1474-9.
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  68. Motley ST, Lory S. Functional characterization of a serine/threonine protein kinase of Pseudomonas aeruginosa. Infect Immun. 1999 Oct; 67(10):5386-94.
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  69. Nugon-Baudon L, Rabot S, Flinois JP, Lory S, Beaune P. Effects of the bacterial status of rats on the changes in some liver cytochrome P450 (EC 1.14.14.1) apoproteins consequent to a glucosinolate-rich diet. Br J Nutr. 1998 Sep; 80(3):231-4.
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  70. Grolier P, Borel P, Duszka C, Lory S, Alexandre-Gouabau MC, Azais-Braesco V, Nugon-Baudon L. The bioavailability of alpha- and beta-carotene is affected by gut microflora in the rat. Br J Nutr. 1998 Aug; 80(2):199-204.
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  71. Pepe JC, Lory S. Amino acid substitutions in PilD, a bifunctional enzyme of Pseudomonas aeruginosa. Effect on leader peptidase and N-methyltransferase activities in vitro and in vivo. J Biol Chem. 1998 Jul 24; 273(30):19120-9.
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  72. Arora SK, Ritchings BW, Almira EC, Lory S, Ramphal R. The Pseudomonas aeruginosa flagellar cap protein, FliD, is responsible for mucin adhesion. Infect Immun. 1998 Mar; 66(3):1000-7.
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  73. Lory S. Secretion of proteins and assembly of bacterial surface organelles: shared pathways of extracellular protein targeting. Curr Opin Microbiol. 1998 Feb; 1(1):27-35.
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  74. Francetic O, Lory S, Pugsley AP. A second prepilin peptidase gene in Escherichia coli K-12. Mol Microbiol. 1998 Feb; 27(4):763-75.
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  75. Turner LR, Olson JW, Lory S. The XcpR protein of Pseudomonas aeruginosa dimerizes via its N-terminus. Mol Microbiol. 1997 Dec; 26(5):877-87.
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  76. Arora SK, Ritchings BW, Almira EC, Lory S, Ramphal R. A transcriptional activator, FleQ, regulates mucin adhesion and flagellar gene expression in Pseudomonas aeruginosa in a cascade manner. J Bacteriol. 1997 Sep; 179(17):5574-81.
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  77. Lu HM, Motley ST, Lory S. Interactions of the components of the general secretion pathway: role of Pseudomonas aeruginosa type IV pilin subunits in complex formation and extracellular protein secretion. Mol Microbiol. 1997 Jul; 25(2):247-59.
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  78. Lory S, Strom MS. Structure-function relationship of type-IV prepilin peptidase of Pseudomonas aeruginosa--a review. Gene. 1997 Jun 11; 192(1):117-21.
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  79. Wang J, Lory S, Ramphal R, Jin S. Isolation and characterization of Pseudomonas aeruginosa genes inducible by respiratory mucus derived from cystic fibrosis patients. Mol Microbiol. 1996 Dec; 22(5):1005-12.
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  80. Lory S, Jin S, Boyd JM, Rakeman JL, Bergman P. Differential gene expression by Pseudomonas aeruginosa during interaction with respiratory mucus. Am J Respir Crit Care Med. 1996 Oct; 154(4 Pt 2):S183-6.
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  81. Wang J, Mushegian A, Lory S, Jin S. Large-scale isolation of candidate virulence genes of Pseudomonas aeruginosa by in vivo selection. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10434-9.
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  82. Arora SK, Ritchings BW, Almira EC, Lory S, Ramphal R. Cloning and characterization of Pseudomonas aeruginosa fliF, necessary for flagellar assembly and bacterial adherence to mucin. Infect Immun. 1996 Jun; 64(6):2130-6.
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  83. Fontaine N, Meslin JC, Lory S, Andrieux C. Intestinal mucin distribution in the germ-free rat and in the heteroxenic rat harbouring a human bacterial flora: effect of inulin in the diet. Br J Nutr. 1996 Jun; 75(6):881-92.
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  84. Hardie KR, Lory S, Pugsley AP. Insertion of an outer membrane protein in Escherichia coli requires a chaperone-like protein. EMBO J. 1996 Mar 1; 15(5):978-88.
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  85. Boyd JM, Lory S. Dual function of PilS during transcriptional activation of the Pseudomonas aeruginosa pilin subunit gene. J Bacteriol. 1996 Feb; 178(3):831-9.
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  86. Lu HM, Lory S. A specific targeting domain in mature exotoxin A is required for its extracellular secretion from Pseudomonas aeruginosa. EMBO J. 1996 Jan 15; 15(2):429-36.
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  87. Ritchings BW, Almira EC, Lory S, Ramphal R. Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin. Infect Immun. 1995 Dec; 63(12):4868-76.
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  88. Simpson DA, Ramphal R, Lory S. Characterization of Pseudomonas aeruginosa fliO, a gene involved in flagellar biosynthesis and adherence. Infect Immun. 1995 Aug; 63(8):2950-7.
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  89. Jin S, Ishimoto KS, Lory S. PilR, a transcriptional regulator of piliation in Pseudomonas aeruginosa, binds to a cis-acting sequence upstream of the pilin gene promoter. Mol Microbiol. 1994 Dec; 14(5):1049-57.
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  90. Zhang HZ, Lory S, Donnenberg MS. A plasmid-encoded prepilin peptidase gene from enteropathogenic Escherichia coli. J Bacteriol. 1994 Nov; 176(22):6885-91.
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  91. Cervin MA, Simpson DA, Smith AL, Lory S. Differences in eucaryotic cell binding of Pseudomonas. Microb Pathog. 1994 Nov; 17(5):291-9.
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  92. Boyd JM, Koga T, Lory S. Identification and characterization of PilS, an essential regulator of pilin expression in Pseudomonas aeruginosa. Mol Gen Genet. 1994 Jun 3; 243(5):565-74.
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  93. Gautom RK, Lory S, Seyedirashti S, Bergeron DL, Fritsche TR. Mitochondrial DNA fingerprinting of Acanthamoeba spp. isolated from clinical and environmental sources. J Clin Microbiol. 1994 Apr; 32(4):1070-3.
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  94. Jin S, Ishimoto K, Lory S. Nucleotide sequence of the rpoN gene and characterization of two downstream open reading frames in Pseudomonas aeruginosa. J Bacteriol. 1994 Mar; 176(5):1316-22.
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  95. Strom MS, Nunn DN, Lory S. Posttranslational processing of type IV prepilin and homologs by PilD of Pseudomonas aeruginosa. Methods Enzymol. 1994; 235:527-40.
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  96. Lu HM, Mizushima S, Lory S. A periplasmic intermediate in the extracellular secretion pathway of Pseudomonas aeruginosa exotoxin A. J Bacteriol. 1993 Nov; 175(22):7463-7.
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  97. Turner LR, Lara JC, Nunn DN, Lory S. Mutations in the consensus ATP-binding sites of XcpR and PilB eliminate extracellular protein secretion and pilus biogenesis in Pseudomonas aeruginosa. J Bacteriol. 1993 Aug; 175(16):4962-9.
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  98. Strom MS, Bergman P, Lory S. Identification of active-site cysteines in the conserved domain of PilD, the bifunctional type IV pilin leader peptidase/N-methyltransferase of Pseudomonas aeruginosa. J Biol Chem. 1993 Jul 25; 268(21):15788-94.
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  99. Nunn DN, Lory S. Cleavage, methylation, and localization of the Pseudomonas aeruginosa export proteins XcpT, -U, -V, and -W. J Bacteriol. 1993 Jul; 175(14):4375-82.
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  100. Koga T, Ishimoto K, Lory S. Genetic and functional characterization of the gene cluster specifying expression of Pseudomonas aeruginosa pili. Infect Immun. 1993 Apr; 61(4):1371-7.
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  101. Strom MS, Nunn DN, Lory S. A single bifunctional enzyme, PilD, catalyzes cleavage and N-methylation of proteins belonging to the type IV pilin family. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2404-8.
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  102. Lory S, von Tscharner C, Marti E, Bestetti G, Grimm S, Waldvogel A. In situ hybridisation of equine sarcoids with bovine papilloma virus. Vet Rec. 1993 Feb 6; 132(6):132-3.
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  103. Strom MS, Lory S. Structure-function and biogenesis of the type IV pili. Annu Rev Microbiol. 1993; 47:565-96.
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  104. Strom MS, Lory S. Kinetics and sequence specificity of processing of prepilin by PilD, the type IV leader peptidase of Pseudomonas aeruginosa. J Bacteriol. 1992 Nov; 174(22):7345-51.
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  105. Simpson DA, Ramphal R, Lory S. Genetic analysis of Pseudomonas aeruginosa adherence: distinct genetic loci control attachment to epithelial cells and mucins. Infect Immun. 1992 Sep; 60(9):3771-9.
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  106. Ishimoto KS, Lory S. Identification of pilR, which encodes a transcriptional activator of the Pseudomonas aeruginosa pilin gene. J Bacteriol. 1992 Jun; 174(11):3514-21.
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  107. Lory S. Determinants of extracellular protein secretion in gram-negative bacteria. J Bacteriol. 1992 Jun; 174(11):3423-8.
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  108. Starnbach MN, Lory S. The fliA (rpoF) gene of Pseudomonas aeruginosa encodes an alternative sigma factor required for flagellin synthesis. Mol Microbiol. 1992 Feb; 6(4):459-69.
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  109. Nunn DN, Lory S. Components of the protein-excretion apparatus of Pseudomonas aeruginosa are processed by the type IV prepilin peptidase. Proc Natl Acad Sci U S A. 1992 Jan 1; 89(1):47-51.
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  110. Nunn DN, Lory S. Product of the Pseudomonas aeruginosa gene pilD is a prepilin leader peptidase. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3281-5.
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  111. Ramphal R, Koo L, Ishimoto KS, Totten PA, Lara JC, Lory S. Adhesion of Pseudomonas aeruginosa pilin-deficient mutants to mucin. Infect Immun. 1991 Apr; 59(4):1307-11.
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  112. Chi E, Mehl T, Nunn D, Lory S. Interaction of Pseudomonas aeruginosa with A549 pneumocyte cells. Infect Immun. 1991 Mar; 59(3):822-8.
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  113. Strom MS, Nunn D, Lory S. Multiple roles of the pilus biogenesis protein pilD: involvement of pilD in excretion of enzymes from Pseudomonas aeruginosa. J Bacteriol. 1991 Feb; 173(3):1175-80.
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  114. Strom MS, Lory S. Amino acid substitutions in pilin of Pseudomonas aeruginosa. Effect on leader peptide cleavage, amino-terminal methylation, and pilus assembly. J Biol Chem. 1991 Jan 25; 266(3):1656-64.
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  115. Totten PA, Lory S. Characterization of the type a flagellin gene from Pseudomonas aeruginosa PAK. J Bacteriol. 1990 Dec; 172(12):7188-99.
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  116. Mohr CD, Martin DW, Konyecsni WM, Govan JR, Lory S, Deretic V. Role of the far-upstream sites of the algD promoter and the algR and rpoN genes in environmental modulation of mucoidy in Pseudomonas aeruginosa. J Bacteriol. 1990 Nov; 172(11):6576-80.
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  117. Nunn D, Bergman S, Lory S. Products of three accessory genes, pilB, pilC, and pilD, are required for biogenesis of Pseudomonas aeruginosa pili. J Bacteriol. 1990 Jun; 172(6):2911-9.
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  118. Saiman L, Ishimoto K, Lory S, Prince A. The effect of piliation and exoproduct expression on the adherence of Pseudomonas aeruginosa to respiratory epithelial monolayers. J Infect Dis. 1990 Mar; 161(3):541-8.
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  119. Totten PA, Lara JC, Lory S. The rpoN gene product of Pseudomonas aeruginosa is required for expression of diverse genes, including the flagellin gene. J Bacteriol. 1990 Jan; 172(1):389-96.
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  120. Ishimoto KS, Lory S. Formation of pilin in Pseudomonas aeruginosa requires the alternative sigma factor (RpoN) of RNA polymerase. Proc Natl Acad Sci U S A. 1989 Mar; 86(6):1954-7.
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  121. Samadpour M, Moseley SL, Lory S. Biotinylated DNA probes for exotoxin A and pilin genes in the differentiation of Pseudomonas aeruginosa strains. J Clin Microbiol. 1988 Nov; 26(11):2319-23.
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  122. Lory S, Strom MS, Johnson K. Expression and secretion of the cloned Pseudomonas aeruginosa exotoxin A by Escherichia coli. J Bacteriol. 1988 Feb; 170(2):714-9.
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  123. Johnson K, Lory S. Characterization of Pseudomonas aeruginosa mutants with altered piliation. J Bacteriol. 1987 Dec; 169(12):5663-7.
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  124. Strom MS, Lory S. Mapping of export signals of Pseudomonas aeruginosa pilin with alkaline phosphatase fusions. J Bacteriol. 1987 Jul; 169(7):3181-8.
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  125. Lory S. Effect of iron on accumulation of exotoxin A-specific mRNA in Pseudomonas aeruginosa. J Bacteriol. 1986 Dec; 168(3):1451-6.
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  126. Johnson K, Parker ML, Lory S. Nucleotide sequence and transcriptional initiation site of two Pseudomonas aeruginosa pilin genes. J Biol Chem. 1986 Nov 25; 261(33):15703-8.
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  127. Strom MS, Lory S. Cloning and expression of the pilin gene of Pseudomonas aeruginosa PAK in Escherichia coli. J Bacteriol. 1986 Feb; 165(2):367-72.
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  128. Lory S, Tai PC. Biochemical and genetic aspects of Pseudomonas aeruginosa virulence. Curr Top Microbiol Immunol. 1985; 118:53-69.
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  129. Ding J, Lory S, Tai PC. Orientation and expression of the cloned hemolysin gene of Pseudomonas aeruginosa. Gene. 1985; 33(3):313-21.
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  130. Lory S, Tai PC, Davis BD. Mechanism of protein excretion by gram-negative bacteria: Pseudomonas aeruginosa exotoxin A. J Bacteriol. 1983 Nov; 156(2):695-702.
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  131. Lory S, Tai PC. Characterization of the phospholipase C gene of Pseudomonas aeruginosa cloned in Escherichia coli. Gene. 1983 Apr; 22(1):95-101.
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  132. Lory S, Carroll SF, Bernard PD, Collier RJ. Ligand interactions of diphtheria toxin. I. Binding and hydrolysis of NAD. J Biol Chem. 1980 Dec 25; 255(24):12011-5.
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  133. Carroll SF, Lory S, Collier RJ. Ligand interactions of diphtheria toxin. III. Direct photochemical cross-linking of ATP and NAD to toxin. J Biol Chem. 1980 Dec 25; 255(24):12020-4.
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  134. Lory S, Carroll SF, Collier RJ. Ligand interactions of diphtheria toxin. II. Relationships between the NAD site and the P site. J Biol Chem. 1980 Dec 25; 255(24):12016-9.
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  135. Lory S, Collier RJ. Expression of enzymic activity by exotoxin A from Pseudomonas aeruginosa. Infect Immun. 1980 May; 28(2):494-501.
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  136. Lory S, Collier RJ. Diphtheria toxin: nucleotide binding and toxin heterogeneity. Proc Natl Acad Sci U S A. 1980 Jan; 77(1):267-71.
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  137. Collier RJ, Gilliland DG, Lory S. Structure-activity relationships in diphtheria toxin and exotoxin A from Pseudomonas aeruginosa. Prog Clin Biol Res. 1979; 31:751-9.
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