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Roger Greenwood Mark, PH.D., M.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressMass Institute Of Technology
Room E25-505
77 Massachusetts Ave
Cambridge MA 02139
Phone617/253-7818
Fax617/258-7859

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Celi LA, Scott DJ, Lee J, Nelson R, Alper SL, Mukamal KJ, Mark RG, Danziger J. Association of hypermagnesemia and blood pressure in the critically ill. J Hypertens. 2013 Nov; 31(11):2136-41.
    View in: PubMed
  2. Lehman LW, Nemati S, Adams RP, Moody G, Malhotra A, Mark RG. Tracking progression of patient state of health in critical care using inferred shared dynamics in physiological time series. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul; 2013:7072-5.
    View in: PubMed
  3. Anthony Celi L, Mark RG, Stone DJ, Montgomery RA. "Big data" in the intensive care unit. Am J Respir Crit Care Med. 2013 Jun 1; 187(11):1157-60.
    View in: PubMed
  4. Danziger J, William JH, Scott DJ, Lee J, Lehman LW, Mark RG, Howell MD, Celi LA, Mukamal KJ. Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int. 2013 Apr; 83(4):692-9.
    View in: PubMed
  5. Scott DJ, Lee J, Silva I, Park S, Moody GB, Celi LA, Mark RG. Accessing the public MIMIC-II intensive care relational database for clinical research. BMC Med Inform Decis Mak. 2013; 13:9.
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  6. Lehman LW, Saeed M, Talmor D, Mark R, Malhotra A. Methods of Blood Pressure Measurement in the ICU*. Crit Care Med. 2013 Jan; 41(1):34-40.
    View in: PubMed
  7. Mandelbaum T, Lee J, Scott DJ, Mark RG, Malhotra A, Howell MD, Talmor D. Empirical relationships among oliguria, creatinine, mortality, and renal replacement therapy in the critically ill. Intensive Care Med. 2013 Mar; 39(3):414-9.
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  8. Lehman LW, Saeed M, Long W, Lee J, Mark R. Risk stratification of ICU patients using topic models inferred from unstructured progress notes. AMIA Annu Symp Proc. 2012; 2012:505-11.
    View in: PubMed
  9. Lehman LW, Nemati S, Adams RP, Mark RG. Discovering shared dynamics in physiological signals: Application to patient monitoring in ICU. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:5939-42.
    View in: PubMed
  10. Silva I, Lee J, Mark RG. Signal quality estimation with multichannel adaptive filtering in intensive care settings. IEEE Trans Biomed Eng. 2012 Sep; 59(9):2476-85.
    View in: PubMed
  11. Mandelbaum T, Scott DJ, Lee J, Mark RG, Malhotra A, Waikar SS, Howell MD, Talmor D. Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria. Crit Care Med. 2011 Dec; 39(12):2659-64.
    View in: PubMed
  12. Saeed M, Villarroel M, Reisner AT, Clifford G, Lehman LW, Moody G, Heldt T, Kyaw TH, Moody B, Mark RG. Multiparameter Intelligent Monitoring in Intensive Care II: a public-access intensive care unit database. Crit Care Med. 2011 May; 39(5):952-60.
    View in: PubMed
  13. Moody GB, Mark RG, Goldberger AL. PhysioNet: physiologic signals, time series and related open source software for basic, clinical, and applied research. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:8327-30.
    View in: PubMed
  14. Silva I, Lee J, Mark R. Photoplethysmograph quality estimation through multichannel filtering. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4361-4.
    View in: PubMed
  15. Lee J, Scott DJ, Villarroel M, Clifford GD, Saeed M, Mark RG. Open-access MIMIC-II database for intensive care research. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:8315-8.
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  16. Lojun SL, Sauper CJ, Medow M, Long WJ, Mark RG, Barzilay R. Investigating Resuscitation Code Assignment in the Intensive Care Unit using Structured and Unstructured Data. AMIA Annu Symp Proc. 2010; 2010:467-71.
    View in: PubMed
  17. Lee J, Mark RG. An investigation of patterns in hemodynamic data indicative of impending hypotension in intensive care. Biomed Eng Online. 2010; 9:62.
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  18. Li Q, Mark RG, Clifford GD. Artificial arterial blood pressure artifact models and an evaluation of a robust blood pressure and heart rate estimator. Biomed Eng Online. 2009; 8:13.
    View in: PubMed
  19. Sun JX, Reisner AT, Saeed M, Heldt T, Mark RG. The cardiac output from blood pressure algorithms trial. Crit Care Med. 2009 Jan; 37(1):72-80.
    View in: PubMed
  20. Neamatullah I, Douglass MM, Lehman LW, Reisner A, Villarroel M, Long WJ, Szolovits P, Moody GB, Mark RG, Clifford GD. Automated de-identification of free-text medical records. BMC Med Inform Decis Mak. 2008; 8:32.
    View in: PubMed
  21. Aboukhalil A, Nielsen L, Saeed M, Mark RG, Clifford GD. Reducing false alarm rates for critical arrhythmias using the arterial blood pressure waveform. J Biomed Inform. 2008 Jun; 41(3):442-51.
    View in: PubMed
  22. Jia X, Malhotra A, Saeed M, Mark RG, Talmor D. Risk factors for ARDS in patients receiving mechanical ventilation for > 48 h. Chest. 2008 Apr; 133(4):853-61.
    View in: PubMed
  23. Jia X, Malhotra A, Saeed M, Mark RG, Talmor D. Risk factors for ARDS in patients mechanically ventilated for >48 hours. CHEST. 2008; 133:853-861.
  24. Aboukhalil A, Nielsen L, Saeed M, Mark RG, Clifford GD. Reducing false alarm rates for critical arrhythmias: a large-scale MIMIC II study. J Biomed Inform. 2008; (in review).
  25. Li Q, Mark RG, Clifford GD. Robust heart rate estimation from multiple asynchronous noisy sources using signal quality indices and a Kalman filter. Physiol Meas. 2008 Jan; 29(1):15-32.
    View in: PubMed
  26. Villarroel M, Saeed A, Clifford GD, Moody GB, Mark RG. Finding relevant cases in large databases of signals, time series, and clinical data. Comput Cardiol. 2007; 34:265-268.
  27. Lehman LH, Kyaw TH, Clifford GD, Mark RG. A temporal search engine for a massive multi-parameter clinical information database. Comput Cardiol. 2007; 34:637-640.
  28. Jia X, Malhotra A, Talmor D, Saeed M, Mark RG. Risk factors for acute lung injury and acute respiratory distress syndrome in patients mechanically ventilated >48 hours in the ICU. SSCM Critical Care Congress, Orlando FL, Feb. 2007. 2007.
  29. Reisner AT, Clifford GD, Mark RG. Ch 1: The physiological basis of the electrocardiogram in advanced methods and tools for ECG analysis. Engineering in Medicine and Biology. 2006; 1:1-25.
  30. Heldt T, Long W, Verghese GC, Szolovits P, Mark RG. Integrating data, models, and reasoning in critical care. Proceedings. 2006; 350-353.
  31. Mukkamala R, Reisner AT, Hojman HM, Mark RG, Cohen RJ. Continuous cardiac output monitoring by peripheral blood pressure waveform analysis. IEEE Trans Biomed Eng. 2006 Mar; 53(3):459-67.
    View in: PubMed
  32. Saeed M, Mark R. A novel method for the efficient retrieval of similar multiparameter physiologic time series using wavelet-based symbolic representations. AMIA Annu Symp Proc. 2006; 679-83.
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  33. Saeed M, Mark RG. A novel method for the efficient retrieval of similar multiparameter physiologic time series using wavelet-based symbolic representations. Proceedings. 2006; 679-683.
  34. Sun JX, Reisner AT, Mark RG. A signal abnormality index for arterial blood pressure waveforms. Comput Cardiol. 2006; 33:13-16.
  35. Clifford GD, Aboukhalil A, Sun JX, Zong W, Janz BA, Moody GB, Mark RG. Using the blood pressure waveform to reduce critical false ECG alarms. Comput Cardiol. 2006; 33:829-832.
  36. Heldt T, Long B, Verghese GC, Szolovits P, Mark RG. Integrating data, models, and reasoning in critical care. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:350-3.
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  37. Janz BA, Frassica JF, Baker C, Clifford GD, Mark RG. A new paradigm for managing information in the ICU in response to the 80 hour work week. New England Surgical Society, Sept. 30-Oct. 2, 2005, Bretton Woods, NH. 2005; 86:118-119.
  38. Heldt T, Chang JL, Chen JJ, Verghese GC, Mark RG. Cycle-averaged dynamics of a periodically driven, closed-loop circulation model. Control Eng Pract. 2005 Sep; 13(9):1163-71.
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  39. Samar Z, Heldt T, Verghese GC, Mark RG. Model-based cardiovascular parameter estimation in the intensive care unit. Comput Cardiol. 2005; 32:635-638.
  40. Douglass MM, Clifford GD, Reisner A, Long WJ, Moody GB, Mark RG. De-identification algorithm for free-text nursing notes. Comput Cardiol. 2005; 32:331-334.
  41. Oefinger MB, Mark RG. A web-based tool for visualization and collaborative annotation of physiological databases. Comput Cardiol. 2005; 32:163-165.
  42. Oefinger MB, Krieger M, Mark RG. Long-term ECG trends in atherosclerotic mouse subjects. Comput Cardiol. 2005; 32:695-698.
  43. Clifford GD, Zapanta LF, Janz BA, Mietus JE, Youn CY, Mark RG. Segmentation of 24-hour cardiovascular activity using ECG-based sleep/sedation and noise metrics. Comput Cardiol. 2005; 32:595-598.
  44. Sun JX, Reisner AT, Saeed M, Mark RG. Estimating cardiac output from arterial blood pressure waveforms: a critical evaluation using the MIMIC II database. Comput Cardiol. 2005; 32:295-298.
  45. Janz BA, Saeed M, Frassica J, Clifford GD, Mark RG. Development and optimization of a Critical Care Alert and Display (CCAD) system using retrospective ICU databases. AMIA Annu Symp Proc. 2005; 994.
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  46. Heldt T, Mark RG. Understanding post-spaceflight orthostatic intolerance - a simulation study. Comput Cardiol. 2005; 32:631-634.
  47. Janz BA, Clifford GD, Mietus JE, Mark RG. A multivariable analysis of sedation, activity and agitation in critically ill patients using the Riker scale, ECG, blood pressure and respiratory rate. Comput Cardiol. 2005; 32:735-738.
  48. Saeed M, Janz B, Clifford GD, Abdala O, Kyaw T, Douglass M, Shu J, Reisner A, Long W, Szolovits P, Heldt T, Verghese G, Moody G, Raber G, Nielsen L, Zong W, Henry I, Frassica J, Mark R. MIMIC II: a massive temporal database to support research in integrating data, models, and reasoning in critical care. AMIA conference, Oct. 2005, Washington DC. 2005.
  49. Janz BA, Saeed M, Frassica J, Clifford GD, Mark RG. Development and optimization of a critical care alert and display (CCAD) system using retrospective ICU databases. AMIA 2005 Symposium Proceedings. 2005; 994.
  50. Zong W, Moody GB, Mark RG. Reduction of false arterial blood pressure alarms using signal quality assessment and relationships between the electrocardiogram and arterial blood pressure. Med Biol Eng Comput. 2004 Sep; 42(5):698-706.
    View in: PubMed
  51. Jager F, Moody GB, Mark RG. Protocol to assess robustness of ST analysers: a case study. Physiol Meas. 2004 Jun; 25(3):629-43.
    View in: PubMed
  52. Oefinger M, Zong W, Krieger M, Mark RG. An interactive web-based tool for multi-scale physiological data visualization. Comput Cardiol. 2004; 31:753-756.
  53. Abdala OT, Clifford GD, Saeed M, Reisner A, Moody GB, Henry I, Mark RG. The annotation station: an open-source technology for annotating large biomedical databases. Comput Cardiol. 2004; 31:681-684.
  54. Abdala OT, Saeed M. Estimation of missing values in clinical laboratory measurements of ICU patients using a weighted k-nearest neighbors algorithm. Comput Cardiol. 2004; 31:693-696.
  55. Jager F, Smrdel A, Mark RG. An open-source tool to evaluate performance of transient ST segment episode detection algorithms. Comput Cardiol. 2004; 31:585-588.
  56. Heldt T, Mark RG. Scaling cardiovascular parameters for population simulations. Comput Cardiol. 2004; 31:133-136.
  57. Oefinger M, Moody GB, Krieger M, Mark RG. System for remote multi-channel real-time monitoring of ECG via the internet. Comput Cardiol. 2004; 31:753-756.
  58. Shu J, Clifford GD, Saeed M, Long WJ, Moody GB, Szolovits P, Mark RG. An open-source, interactive java-based system for rapid encoding of significant events in the ICU using the unified medical language system. Comput Cardiol. 2004; 31:197-200.
  59. Douglass M, Clifford GD, Reisner A, Moody GB, Mark RG . Computer-assisted deidentification of free text in the MIMIC II database. Comput Cardiol. 2004; 31:341-344.
  60. Jager F, Taddei A, Moody GB, Emdin M, Antolic G, Dorn R, Smrdel A, Marchesi C, Mark RG. Long-term ST database: a reference for the development and evaluation of automated ischaemia detectors and for the study of the dynamics of myocardial ischaemia. Med Biol Eng Comput. 2003 Mar; 41(2):172-82.
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  61. Chen JJS, Heldt T, Verghese GC, Mark RG. Analytical solution to simplified circulatory model using piecewise linear elastance. Comput Cardiol. 2003; 30:45-48.
  62. Heldt T, Verghese GC, Kamm RD, and Mark RG. Modeling cardiovascular response to gravitational stress—combined forward and inverse approach. IFMBE Proceedings—World Congress on Medical Physics and Biomedical Engineering. 2003.
  63. Heldt T, Chang JL, Verghese GC, and Mark RG. Cycle-averaged models of cardiovascular dynamics. Proceedings. 2003; 387-392.
  64. Heldt T, Oefinger MB, Hoshiyama M, Mark RG. Circulatory response to passive and active changes in posture. Comput Cardiol. 2003; 30:263-266.
  65. Zong W, Heldt T, Moody GB, Mark RG. An open-source algorithm to detect onset of arterial blood pressure pulses. Comput Cardiol. 2003; 30:259-262.
  66. Mukkamala R, Reisner AT, Hojman HM, Mark RG, Cohen RJ. Continuous cardiac output monitoring by peripheral blood pressure waveform analysis. Comput Cardiol. 2003; 30:255-258.
  67. Zong W, Wang PJ, Leung B, Moody GB, Garan AR, Mark RG. A new web-enabled searchable archiving system for ICD stored data and waveforms. Circulation. 2002; 106(19, Suppl S.):408-409.
  68. Heldt T, Shim EB, Kamm RD, Mark RG. Computational modeling of cardiovascular response to orthostatic stress. J Appl Physiol. 2002 Mar; 92(3):1239-54.
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  69. Shim EB, Youn CH, Heldt T, Kamm RD, Mark RG. Computational modeling of the cardiovascular system after Fontan procedure. Proceedings. 2002; 105-114.
  70. Mukkamala R, Cohen RJ, Mark RG. A computational model-based validation of Guyton's analysis of cardiac output and venous return curves. Comput Cardiol. 2002; 29:561-4.
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  71. Zong W, Wang P, Leung B, Moody GB, Mark RG. An automated, web-enabled and searchable database system for archiving electrogram and related data from implantable cardioverter defibrillators. Comput Cardiol. 2002; 29:269-72.
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  72. Saeed M, Lieu C, Raber G, Mark RG. MIMIC II: a massive temporal ICU patient database to support research in intelligent patient monitoring. Comput Cardiol. 2002; 29:641-4.
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  73. Jager F, Taddei A, Moody G, Emdin M, Antolic G, Smrdel A, Marchesi C, Mark RG. The long-term ST database: reference for automated ischaemia detection systems and for studies of transient myocardial ischaemia. European Heart Journal. 2002; 23 (Aug.-Sept.), Suppl. S:116.
  74. Moody GB, Mark RG, Goldberger AL. PhysioNet: a Web-based resource for the study of physiologic signals. IEEE Eng Med Biol Mag. 2001 May-Jun; 20(3):70-5.
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  75. Moody GB, Mark RG. The impact of the MIT-BIH arrhythmia database. IEEE Eng Med Biol Mag. 2001 May-Jun; 20(3):45-50.
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  76. Choi HG, Mukkamala R, Moody GB, Mark RG. Do nonlinearities play a significant role in short term, beat-to-beat variability? Comput Cardiol. 2001; 28:53-6.
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  77. Mukkamala R, Mark RG, and Cohen RJ. A noninvasive method for characterizing ventricular diastolic filling dynamics. Proceedings (electronic publication). 2001; 1:147-150.
  78. Saeed M, Mark RG. Efficient hemodynamic event detection utilizing relational databases and wavelet analysis. Comput Cardiol. 2001; 28:153-6.
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  79. Mukkamala R, Moody GB, Mark RG. Introduction of computational models to PhysioNet. Comput Cardiol. 2001; 28:77-80.
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  80. Heldt T, Shim EB, Kamm RD, Mark RG. Model-based parameter estimation using cardiovascular response to orthostatic stress. Comput Cardiol. 2001; 28:337-40.
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  81. Zong W, Mukkamala R, Mark RG. A methodology for predicting paroxysmal atrial fibrillation based on ecg arrhythmia feature analysis. Comput Cardiol. 2001; 28:125-128.
  82. Goldberger AL, Amaral LA, Glass L, Hausdorff JM, Ivanov PC, Mark RG, Mietus JE, Moody GB, Peng CK, Stanley HE. PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals. Circulation. 2000 Jun 13; 101(23):E215-20.
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  83. Jager F, Taddei A, Emdin M, Antolic G, Dorn R, Moody GB, Smrdel A, Varanini M, Bordigiago S, Marchesi C, Mark RG. The long-term ST database: a research resource for algorithm development and physiologic studies of transient myocardial ischemia. Comput Cardiol. 2000; 27:841-844.
  84. Heldt T, Shim EB, Kamm RD, Mark RG. Computational model of cardiovascular function during orthostatic stress. Comput Cardiol. 2000; 27:777-80.
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  85. Saeed M, Mark RG. Multiparameter trend monitoring and intelligent displays using wavelet analysis. Comput Cardiol. 2000; 27:797-800.
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  86. Moody GB, Mark RG, Goldberger AL. PhysioNet: a research resource for studies of complex physiologic and biomedical signals. Comput Cardiol. 2000; 27:179-82.
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  87. Penzel T, Moody GB, Mark RG, Goldberger AL, Peter JH. The Apnea-ECG database. Comput Cardiol. 2000; 27:255-258.
  88. Shim EB, Kamm RD, Heldt T, Mark RG. Numerical analysis of blood flow through a stenosed artery using a coupled, multiscale simulation method. Comput Cardiol. 2000; 27:219-22.
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  89. Moody GB, Mark RG, Goldberger AL, Penzel T. Stimulating rapid research advances via focused competition: the Computers in Cardiology Challenge 2000. Comput Cardiol. 2000; 27:207-210.
  90. Laguna P, Moody GB, García J, Goldberger AL, Mark RG. Analysis of the ST-T complex of the electrocardiogram using the Karhunen--Loève transform: adaptive monitoring and alternans detection. Med Biol Eng Comput. 1999 Mar; 37(2):175-89.
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  91. Zhao R, Mark RG, Szolovits P. A model-based expert system for improving assessment of patients with cardiovascular diseases in intensive care units. Journal of the American College of Cardiology. 1999; 33(2 Suppl. A):5A-6A.
  92. Zong W, Moody GB, Mark RG. Reduction of false blood pressure alarms by use of electrocardiogram blood pressure relationships. Comput Cardiol. 1999; 26:305-308.
  93. Shim EB, Kamm RD, Heldt T, Mark RG. Computational modeling of cardiovascular system after the Fontan procedure. Bioengineering Conference ASM BED. 1999; 42:15-16.
  94. Smrdel A, Moody GB, Antolic G, Jager F, Mark RG. Relationships among heart rate, patterns of ischemic change and time of day. Comput Cardiol. 1999; 26:551-554.
  95. Heldt T, Shim EB, Kamm RD, Mark RG. Computational models of cardiovascular function for analysis of post-flight orthostatic intolerance. Comput Cardiol. 1999; 26:213-6.
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  96. Jager F, Moody GB, Mark RG. Detection of transient ST segment episodes during ambulatory ECG monitoring. Comput Biomed Res. 1998 Oct; 31(5):305-22.
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  97. Laguna P, Moody GB, Mark RG. Power spectral density of unevenly sampled data by least-square analysis: performance and application to heart rate signals. IEEE Trans Biomed Eng. 1998 Jun; 45(6):698-715.
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  98. Laguna P, García J, Roncal I, Wagner G, Lander P, Mark R. Model-based estimation of cardiovascular repolarization features: ischaemia detection and PTCA monitoring. J Med Eng Technol. 1998 Mar-Apr; 22(2):64-72.
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  99. Zong W, Moody GB, Mark RG. Effects of vasoactive drugs on the relationship between ECG-pulse wave delay time and arterial blood pressure in ICU patients. Comput Cardiol. 1998; 25:673-676.
  100. Jager F, Moody GB, Taddei A, Anolic G, Emdin M, Smrdel A, Glavic B, Marchesi C, Mark RG. A long-term ST database for development and evaluation of ischemia detectors. Comput Cardiol. 1998; 25:301-304.
  101. Jager F, Moody GB, Taddei A, Antolic G, Smrdel A, Glavic B, Emdin M, Marchesi C, Mark RG. Research resources for development and evaluation of transient ischemia detectors. Informatica Medica Slovenica. 1998; 5:45-54.
  102. Moody GB, Mark RG. Integration of real-time and off-line clinical data in the MIMIC database. Comput Cardiol. 1997; 24:585-588.
  103. Laguna P, Mark RG, Goldberger A, Moody GB. A database for evaluation of algorithms for measurement of QT and other waveform intervals in the ECG. Comput Cardiol. 1997; 24:673-676.
  104. Jager F, Moody GB, Antolic G, Masic D, Mark RG. Sympatho-vagal correlates of transient ischemia in ambulatory patients. Comput Cardiol. 1997; 24:387-390.
  105. Mark RG, Moody GB. ECG arrhythmia analysis: design and evaluation strategies. Gath, I., and Inbar, G.F., eds., Advances in Processing and Pattern Analysis of Biomedical Signals. 1996.
  106. Moody GB, Mark RG. A database to support development and evaluation of intelligent intensive care monitoring. Comput Cardiol. 1996; 23:657-660.
  107. Jager F, Moody GB, Taddei A, Antolic G, Zabukovec M, Skrjanc M, Emdin M, Mark RG. Development of a long term database for assessing the performance of transient ischemia detectors. Comput Cardiol. 1996; 23:481-484.
  108. Laguna P, Ruiz M, Moody GB, Mark RG. Repolarization alternans detection using the KL transform and the beatquency spectrum. Comput Cardiol. 1996; 23:673-676.
  109. Garcia J, Olmos S, Moody GB, Mark RG, Laguna P. Adaptive estimation of Karhunen-Loeve Series applied to the study of ischemic ECG records. Comput Cardiol. 1996; 23:249-252.
  110. Zhao R, Mark RG, Szolovits P. A model-based expert system for interpretation of hemodynamic data from ICU patients. Comput Cardiol. 1996; 23:585-588.
  111. Jager F, Moody GB, Pavlic B, Blazina I, Zupic I, Mark RG. Characterization of temporal patterns of transient ischemic ST change episodes during ambulatory ECG monitoring. Comput Cardiol. 1996; 23:681-684.
  112. Jager F, Moody GB, Mark RG. Characterization of transient ischemic and non-ischemic ST segment changes. Comput Cardiol. 1995; 22:721-724.
  113. Silipo R, Laguna P, Marchesi C, Mark, RG. ST-T segment change recognition using artificial neural networks and principal component analysis. Comput Cardiol. 1995; 22:213-216.
  114. Laguna P, Moody GB, Jané R, Caminal P, Mark RG. Karhunen-Loève transform as a tool to analyze the ST-segment. Comparison with QT interval. J Electrocardiol. 1995; 28 Suppl:41-9.
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  115. Moody GB, Mark RG. The MIT-BIH arrhythmia database CD-ROM. World Congress on Medical Physics and Biomedical Engineering, Rio De Janeiro, Brazil. 1994.
  116. Laguna P, Jané R, Moody GB, Caminal P, Mark RG. ECG signal analysis of the ventricular repolarization period: QT interval and ST-T waveform measurements. World Congress on Medical Physics and Biomedical Engineering, Rio De Janeiro, Brazil. 1994.
  117. Jager F, Moody GB, Divjak S, Mark RG. Assessing the robustness of algorithms for detecting transient ischemic ST segment changes. Comput Cardiol. 1994; 21:229-232.
  118. Mark RG, Artis SG, Chow H, Moody GB. Neural network applications in arrhythmia analysis. World Congress on Medical Physics and Biomedical Engineering, Rio De Janeiro, Brazil. 1994.
  119. Laguna P, Moody GB, Mark RG. Analysis of the cardiac repolarization period using the KL transform: Applications on the ST-T database. Comput Cardiol. 1994; 21:233-236.
  120. Lee CC, Mark RG. Analysis of arterial waves by the single-pulse-response method. IEEE Trans Biomed Eng. 1993 Aug; 40(8):833-6.
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  121. Ocasio WC, Rigney DR, Clark KP, Mark RG. bpshape wk4: a computer program that implements a physiological model for analyzing the shape of blood pressure waveforms. Comput Methods Programs Biomed. 1993 Apr; 39(3-4):169-94.
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  122. Rigney DF, Goldberger AL, Ocasio WC, Ichimaru Y, Moody GB, Mark RG. Multi-channel physiological data: description and analysis (data set B). Times Series Prediction: Forecasting the Future and Understanding the Past. Eds. A. S. Weigend and N. A. Gershenfeld, SFI Studies in the Sciences of Complexity. 1993; Proc. Vol. XV:105-129.
  123. Lee CC, Mark RG. Study of arterial pressure waves using a simple tube model of the ventriculo-arterial system. Comput Cardiol. 1993; 20: 771-774.
  124. Greenwald SD, Patil RS, Mark RG. Improved detection and classification of arrhythmias in noise-corrupted electrocardiograms using contextual information within an expert system. Biomed Instrum Technol. 1992 Mar-Apr; 26(2):124-32.
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  125. Jager F, Mark RG, Moody GB, Divjak S. Analysis of transient ST segment changes during ambulatory monitoring using the Karhunen-Loève transform. Comput Cardiol. 1992; 19:691-694.
  126. Chow HS, Moody GB, Mark RG. Detection of ventricular ectopic beats using neural networks. Comput Cardiol. 1992; 19:659-662.
  127. Chia CW, Saul JP, Lee CC, Mark RG. Monitoring the changes in peripheral vascular resistance using the shape of the radial blood pressure pulse. Comput Cardiol. 1992; 19:567-570.
  128. Jager F, Mark RG, Moody GB. Analysis of transient ST segment changes during ambulatory monitoring. Comput Cardiol. 1991; 18:453-456.
  129. Jager F, Moody GB,Taddei A, Mark RG. Performance measures for algorithms to detect transient ischemic ST segment changes. Comput Cardiol. 1991; 18:369-372.
  130. Artis SG, Mark RG, Moody GB. Detection of atrial fibrillation using artificial neural networks. Comput Cardiol. 1991; 18:173-176.
  131. Habboush I, Moody GB, Mark RG. Neural networks for ECG compression and classification. Comput Cardiol. 1991; 18:185-188.
  132. Israel DA, Edell DJ, Mark RG. Time delays in propagation of cardiac action potential. Am J Physiol. 1990 Jun; 258(6 Pt 2):H1906-17.
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  133. Artis SG, Moody GB, Mark RG. Algorithms for improved detection of supraventricular arrhythmia. Comput Cardiol. 1990; 17:507-510.
  134. Davis TL, Mark RG. Software for teaching cardiovascular hemodynamics. IBM Academic Computing Conference, Miami Beach, FL. 1990.
  135. Clark KP, Mark RG. Extracting New Information from the Shape of the Blood pressure Pulse. Comput Cardiol. 1990; 17:225-228.
  136. Mark RG, Greenwald S. Finding QRS complexes in severe noise by intelligent use of context and experience. J Electrocardiol. 1990; 23 Suppl:198-9.
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  137. Chia WC, Greenwald SD, Mark RG. A comparison of human experts and computer algorithms in detecting and classifying beats in noise-corrupted electrocardiograms. Comput Cardiol. 1990; 17:465-468.
  138. Taddei A, Biagini A, Distante G, Emdin M, Mazzei M, Pisani P, Roggero N,Varanini M, Mark R, Moody G, Braaksma L, Zeelenberg C, Marchesi C. The European ST-T database: development, distribution and use. Comput Cardiol. 1990; 17:177-180.
  139. Davis TL, Mark RG. Teaching physiology through simulation of hemodynamics. Computers in Cardiology. 1990; 17:649-652.
  140. Moody GB, Mark RG. The MIT-BIH arrhythmia database on CD-ROM and software for use with it. Comput Cardiol. 1990; 17:185-188.
  141. Greenwald SD, Patil R, Mark RG. Improved detection and classification of arrhythmias in noise-corrupted electrocardiograms using contextual information. Comput Cardiol. 1990; 17:461-464.
  142. Malek AM, Mark RG. Functional electrical stimulation of the latissimus dorsi muscle for use in cardiac assist. IEEE Trans Biomed Eng. 1989 Jul; 36(7):781-8.
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  143. Madwed JB, Albrecht P, Mark RG, Cohen RJ. Low-frequency oscillations in arterial pressure and heart rate: a simple computer model. Am J Physiol. 1989 Jun; 256(6 Pt 2):H1573-9.
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  144. Moody GB, Mark RG. QRS Morphology Representation and Noise Estimation Using the Karhunen-Loeve Transform. Comput Cardiol. 1989; 16:269-272.
  145. Mark RG, Patil R, Moody G. CALVIN: An expert system to improve arrhythmia detector performance in noise. J Electrophys. 1988; 21(Supp. S):117.
  146. Albrecht P, Cohen RJ, Mark RG. A stochastic characterization of chronic ventricular ectopic activity. IEEE Trans Biomed Eng. 1988 Jul; 35(7):539-50.
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  147. Greenwald SD, Patil RS, Mark RG. Improved arrhythmia detection in noisy ECG through the use of expert systems. Comput Cardiol. 1988; 15:163-165.
  148. Zlateva S, Mark R, Moody G. A two-channel model of baroreceptor dynamics. Bulgarian Acad of Sci, Biomechanics. 1988; 21:49-59.
  149. Albrecht P, Moody GB, Mark RG. Use of the "bootstrap" to assess the robustness of the performance statistics of an arrhythmia detector. .J Ambul Monitoring. 1988; 1(2):171-176.
  150. Israel DA, Edell DJ, Mark RG. Time delays in the propogation of cardiac action potentials. J Am Col Cardiol. 1988; 11(2):179A.
  151. Moody GB, Mark RG, Goldberger AL. Evaluation of the "Trim" ECG data compressor. Comput Cardiol. 1988; 15:167-169.
  152. Mark RG, Moody GB. Automated arrhythmia analysis. Webster JG, ed. Encyclopedia of medical devices and instrumentation. 1988; 1:120-130.
  153. Maddens M, Lipsitz LA, Wei JY, Pluchino FC, Mark R. Impaired heart rate responses to cough and deep breathing in elderly patients with unexplained syncope. Am J Cardiol. 1987 Dec 1; 60(16):1368-72.
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  154. Madwed JB, Albrecht P, Mark RG, Cohen RJ. Low-frequency (0.05 Hz) oscillations (LFO) in arterial blood-pressure (ABP) and heart-rate (HR) - a simple computer-model. Federation Proceedings. 1987; 46(3):673.
  155. Albrecht P, Cohen RJ, Mark RG. A novel method of representing the characteristics of ventricular ectopic activity in Holter recordings. Comput Cardiol. 1987; 14:169-172.
  156. Moody GB, Soroushian K, Mark RG. ECG data compression for tapeless ambulatory monitors. Comput Cardiol. 1987; 14:467-470.
  157. Mark RG. Electrical characteristics of the heart. In: Oxford, England: Pergarmon Press, 1987; Biomedical Measurement:449-456. Singh M, Ed. Systems and Control Encyclopedia. 1987; 449-456.
  158. Miklozek CL, Kingsley EM, Crumpaker CS, Modlin JF, Royal HD, Come PC, Mark R, Abelmann WH. Serial cardiac function tests in myocarditis. Postgrad Med J. 1986 Jun; 62(728):577-9.
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  159. Muldrow WK, Mark RG, Long WJ, Moody GB. CALVIN: A rule based expert system for improving arrhythmia detector performance during noisy ECGs. Comput Cardiol. 1986; 13:21-26.
  160. Albrecht P, Cohen RJ, Mark RG. An analysis of the influence of preceding R-R intervals on generation of ventricular ectopic beats. Comput Cardiol. 1986; 13:335-338.
  161. Moody GB, Mark RG. Clinical validation of the ECG-derived respiration (EDR) technique. Comput Cardiol. 1986; 13:507-510.
  162. Ferguson Jr PF, Mark RG, Burns SK. An algorithm to reduce false positive alarms in arrhythmia detectors using dynamic electrode impedance monitoring. Comput Cardiol. 1986; 13:511-514.
  163. Moody GB, Mark RG, Zoccola A, and Manero S. Derivation of respiratory signals from multi-lead ECGs. Comput Cardiol. 1985; 12:113-116.
  164. Jarisch WR, Albrecht P, Mark RG. Minimal representation of QRS complexes with principal components. Proc. Annual Meeting of Assoc. Advancement Medical Instrumentation. 1985; 38.
  165. Mark RG. Arrhythmia monitoring: current status and future challenges. Patient monitoring and data management. 1985; 7-11.
  166. Greenwald SD, Jarisch WR, Mark RG. Detection of malignant ventricular arrhythmias using linear prediction. Proc. Ann Mtg of Assoc Advancement of Med Instrum. 1985.
  167. Greenwald SD, Albrecht P, Moody GB, Mark RG. Estimating confidence limits for arrhythmia detector performance. Comput Cardiol. 1985; 12:383-386.
  168. Albrecht P, Mark R. Simple probabilistic models for characterization of PVC production. Proceedings of 11th Ann NE Bioengineering Conf, IEEE. 1985; 369-373.
  169. Mark RG, Ripley KL. Ambulatory ECG monitoring: real-time analysis versus tape scanning systems. MD Comput. 1985 Jan-Feb; 2(1):38-50, 68.
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  170. Albrecht P, Jarisch WR, Mark RG. A more sensitive method for detecting changes in the level of ventricular ectopy in long-term ECG recordings. Comput Cardiol. 1985; 12:47-52.
  171. Israel DA, Barry WH, Edell DJ, Mark RG. An array of microelectrodes to stimulate and record from cardiac cells in culture. Am J Physiol. 1984 Oct; 247(4 Pt 2):H669-74.
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  172. Mark RG, Moody GB. Evaluation of automated arrhythmia monitors using an annotated ECG database. Proceedings. 1984; 333-357.
  173. Kavesh WN, Mark RG, Kearney B. Medical care teams improve nursing home care and reduce costs. 37th Ann Sci Mtg Gerontol Soc Am, San Antonio TX. 1984.
  174. Moody GB, Mark RG. Methods for predicting real-world performance of arrhythmia detectors. Proc. Annual Meeting of Assoc. Advancement of Medical Instrumentation. 1984; 57.
  175. Kavesh WN, Mark RG, Kearney, B. Medical care teams improve nursing home care and reduce costs. Gerontologist. 1984; 24(Sp. Iss. Si):132.
  176. Fraeman ME, Wiegner AW, Mark RG, Bing OH. A STOIC-based application language for muscle mechanics research. Comput Biol Med. 1984; 14(2):179-90.
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  177. Moody GB, Muldrow WK, Mark RG. A noise stress test for arrhythmia detectors. Comput Cardiol. 1984; 11:381-384.
  178. Devlin PH, Mark RG, Ketchum JW. Detecting electrode motion noise in ECG signals by monitoring electrode impedance. Comput Cardiol. 1984; 11:227-230.
  179. Jarisch WR, Mark RG. A stochastic modeling approach to cluster identification with application to arrhythmia detection. Comput Cardiol. 1984; 11:185-188.
  180. Mark RG, Ripley KL. Ambulatory monitoring: real-time analysis versus tape scanning systems. Proceedings. 1984; 323-337.
  181. Swerdlow B, Axelrod P, Kolman B, Perry D, Mark R. Ambulatory ventricular tachycardia: characteristics of the initiating beat. Am Heart J. 1983 Dec; 106(6):1326-31.
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  182. Conrad CH, Mark RG, Bing OH. Outward current and repolarization in hypoxic rat myocardium. Am J Physiol. 1983 Mar; 244(3):H341-50.
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  183. Albrecht P, Rice K, Jarisch W, Mark R. Efficient measurement of long-term ST-segment trends. IEEE Frontiers of Engineering and Computing in Health Care (Proc. 5th Ann. Conf. IEEE Eng Med Biol Society). 1983; 644-649.
  184. Phillips P, Mark R, Breed C. Single patient arrhythmia monitor. IEEE, Proc of 36th Ann Conf Engineering in Medicine and Biology (Columbus OH). 1983.
  185. Nobari K, Jarisch WR, Mark RG. Reduction of false alarms in automatic arrhythmia detectors. Proc. of 36th Annual Conf. Engineering in Medicine and Biology (Columbus OH). 1983.
  186. Moody GB, Mark RG. A new method for detecting atrial fibrillation using R-R intervals. Comput Cardiol. 1983; 10:227-230.
  187. Moody GB, Mark RG. How can we predict real-world performance of an arrhythmia detector?. Comput Cardiol. 1983; 10:71-76.
  188. Mark R, Lennox S, Jainchill J, Kavesh W, Master R. An 8-year follow-up study of a nursing home medical care system. 110th annual meeting of American Public Health Association (Montreal, Canada). 1982.
  189. Moody GB, Mark RG. Development and evaluation of a 2-lead ECG analysis program. Comput Cardiol. 1982; 9:39-44.
  190. Mark R, Schluter P, Moody G, Devlin P, Chernoff D. An annotated ECG database for evaluating arrhythmia detectors. Frontiers of Engineering in Health Care (Proc. 4th Annual Conference IEEE Engineering in Medicine and Biology Society). 1982; 205-210.
  191. Mark RG, Moody GB, Schluter PS, Olson WH, Peterson SK. Real-time cardiac arrhythmia monitoring using microprocessors. Pinciroli F, Anderson eds. Changes in health care instrumentation due to microprocessor technology. 1981; 257-271.
  192. Chernoff D, Lee T, Moody GB, Mark RG. Evaluation of R-R interval predictors using an annotated ECG database. Comput Cardiol. 1981; 8:359-362.
  193. Rappaport S, Gillick L, Moody G, and Mark RG. QRS morphology classification: quantitative evaluation of different strategies. Comput Cardiol. 1981; 8:33-38.
  194. Master RJ, Feltin M, Jainchill J, Mark R, Kavesh WN, Rabkin MT, Turner B, Bachrach S, Lennox S. A continuum of care for the inner city: assessment of its benefits for Boston's elderly and high-risk populations. N Engl J Med. 1980 Jun 26; 302(26):1434-40.
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  195. Willemain TR, Mark RB. The distribution of intervals between visits as a basis for assessing and regulating physician services in nursing homes. Med Care. 1980 Apr; 18(4):427-41.
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  196. Moody GB, Mark RG, Olson WH, Peterson SK, Schluter PS, Walters JB. A microprocessor-based ECG monitor for ambulatory patients. Proceedings. 1980; 371-375.
  197. Mark RG, Schluter PS, Moody GB, Peterson SK. Real-time arrhythmia monitoring using microprocessors. Eden HS, Eden M, eds. Microcomputers in patient care. 1980; 137-157.
  198. Conrad CH, Mark RG, Bing OHL. Influence of glucose on the steady-state outward current in hypoxic rat myocardium. Clinical Research. 1980; 28(2):A162.
  199. Mark RG, Moody GB, Olson WH, Peterson SK. Event recorders and future systems. Wenger NK, Mock MB, Ringqvist R, eds. Ambulatory electrocardiographic recording. 1980; 113-132.
  200. Schluter PS, Mark RG, Moody GB, Olson WH, Peterson SK. Performance measures for arrhythmia detectors. Comput Cardiol. 1980; 7:267-270.
  201. Schluter PS, Mark RG. A bedside cardiac arrhythmia monitor. Proceedings. 1980; 381-384.
  202. Mark RG, Moody GB, Olson WH, Peterson SK, Schluter PS, Walters JB. Real-time ambulatory arrhythmia analysis with a microcomputer. Comput Cardiol. 1979; 6:57-62.
  203. Burns SK, Dowling NB, Peterson SK, Pettyjohn RL, Schluter PS, Tole JR, Valvano JW, Mark RG. Experience with a modular microprocessor base for medical instruments. IEEE Conf Eng Cong (Denver, Colorado). 1979.
  204. Mark R, Master R, Willemain T. Medical care to nursing home patients: evaluation of a new system. American Public Health Assoc., 106th annual meeting, Los Angeles, Oct. 15-19, 1978. 1978; 216.
  205. Dowling NB, McFadden ER, Sykes TW, Burns SK, Mark RG. Microcomputer controlled operation of a whole body plethysmograph. Proc. 31st Annual Conf. Engineering in Medicine and Biology. 1978; 20:229.
  206. Schluter PS, Peterson SK, Siegel LC, Walters JB, Mark RG. A database for arrhythmia detector evaluation. Proc. 31st Annual Conf. Engineering in Medicine and Biology. 1978; 20:58.
  207. Asimocopoulos PJ, Axelrod P, Mark RG, Thaler S, Cannon R. An artificial conduction system: the atrial tracking pacemaker. Proc. 29th Annual Conf. Engineering in Medicine and Biology. 1976; 18:21.
  208. Mark RG, Willemain TR. Evaluation of the application of telecommunications to health care delivery in nursing homes. Realizing knowledge as a resource: Proc. of the 2nd symposium on research applied to national needs. 1976; V:116-118.
  209. Conrad CH, Keks B, Derry CD, Mark RG, Slapak M. Normothermic perfusion of canine kidneys. Pegg DE, ed. Organ Preservation. 1975; 42-50.
  210. Mark RG. Communications requirements in telemedicine systems. Bashur R, Armstrong P, Youssef Z, eds. Telemedicine. 1975; 145-152.
  211. Sulman DL, Bing OH, Mark RG, Burns SK. Physiologic loading of isolated heart muscle. Biochem Biophys Res Commun. 1974 Feb 27; 56(4):947-51.
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  212. Mark RG. Telemedicine system: the missing link between homes and hospitals? Mod Nurs Home. 1974 Feb; 32(2):39-42.
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  213. Sulman DL, Bing OHL, Mark RG, Burns SK. Relaxation of isolated cardiac muscle: the effects of physiologic loading. Circ. 1974; 49&50 (Suppl III):208.
  214. Mark RG, Willemain TR, Master RJ. A measure of medical care responsiveness in nursing homes. Clin Res. 1974.
  215. Mark RG, Keshner M. Non-invasive blood pressure measurements using aortic pulse wave velocity. NEREM 74 Record (Proc. IEEE Northeast Electronics Research and Engineering Meeting). 1974; 16:70-72.
  216. Sulman DL, Bing OHL, Mark RG, Burns Sk. Physiologic loading of the isolated cardiac muscle. Clin Res. 1973; 21:954.
  217. Kelinbaum JI, Bing OHL, Mark RG. A load control system for isolated cardiac muscle. Clin Res. 1972; 20:857.
  218. Mark RG. Telemedicine for improved medical care. IEEE International Convention Digest. 1972; 232-233.
  219. Mark RG, Dudley WE, Keazirian M, Liang MH. A hospital-based system for providing nursing home medical care. Clin Res. 1972; 20:875.
  220. Mylrea KC, Mark RG. Considerations in the development of remote health care systems. Biomed Sci Instrum. 1971; 8:1-4.
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  221. Willemain TR, Mark RG. Planning telemedicine systems. NEREM 71 Record (Proc. IEEE Northeast Electronics Research and Engineering Meeting). 1971; 13:268-271.
  222. Willemain TR, Mark RG. Models of remote health care systems. Biomed Sci Instrum. 1971; 8:9-17.
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  223. Mark RG, Smullin L. Telecommunications and medical services. Communications Technology for Urban Improvement. 1971; 63-68.
  224. Mark RG. Telecommunications and health care. NEREM 70 Record (Proc. IEEE Northeast Electronics Research and Engineering Meeting), Technical Applications Papers. 1970; 7-8.
  225. Mark RG, Hall RD. Acoustically evoked potentials in the rat during conditioning. J Neurophysiol. 1967 Jul; 30(4):875-92.
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  226. Hall RD, Mark RG. Fear and the modification of acoustically evoked potentials during conditioning. J Neurophysiol. 1967 Jul; 30(4):893-910.
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  227. Hall RD, Clayton RJ, Mark RG. A device for the partial restraint of rats in operant conditioning studies. J Exp Anal Behav. 1966 Mar; 9(2):143-5.
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