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Last Name
Institution

Lee Michael Kaplan, M.D.,PH.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Gastrointestinal Unit, Jackson 725
55 Fruit St
Boston MA 02114
Phone617/726-3768
Fax617/724-1515

 Mentoring 
 completed student projects
Steatosis and Obesity: Gaining Insight into the Genetics of Obesity
Full Time/Year Long, 11/01/99 - 07/31/00

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhong H, Beaulaurier J, Lum PY, Molony C, Yang X, Macneil DJ, Weingarth DT, Zhang B, Greenawalt D, Dobrin R, Hao K, Woo S, Fabre-Suver C, Qian S, Tota MR, Keller MP, Kendziorski CM, Yandell BS, Castro V, Attie AD, Kaplan LM, Schadt EE. Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet. 2010 May; 6(5):e1000932.
    View in: PubMed
  2. Zhong H, Yang X, Kaplan LM, Molony C, Schadt EE. Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet. 2010 Apr 9; 86(4):581-91.
    View in: PubMed
  3. Kaplan L, Foster R, Shen Y, Parry DM, McMaster ML, O'Leary MC, Gusella JF. Monozygotic twins discordant for neurofibromatosis 1. Am J Med Genet A. 2010 Mar; 152A(3):601-6.
    View in: PubMed
  4. Rubino F, Kaplan LM, Schauer PR, Cummings DE. The Diabetes Surgery Summit consensus conference: recommendations for the evaluation and use of gastrointestinal surgery to treat type 2 diabetes mellitus. Ann Surg. 2010 Mar; 251(3):399-405.
    View in: PubMed
  5. Kaplan LM. Pharmacologic therapies for obesity. Gastroenterol Clin North Am. 2010 Mar; 39(1):69-79.
    View in: PubMed
  6. Rubino F, Schauer PR, Kaplan LM, Cummings DE. Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action. Annu Rev Med. 2010; 61:393-411.
    View in: PubMed
  7. Hägg S, Skogsberg J, Lundström J, Noori P, Nilsson R, Zhong H, Maleki S, Shang MM, Brinne B, Bradshaw M, Bajic VB, Samnegård A, Silveira A, Kaplan LM, Gigante B, Leander K, de Faire U, Rosfors S, Lockowandt U, Liska J, Konrad P, Takolander R, Franco-Cereceda A, Schadt EE, Ivert T, Hamsten A, Tegnér J, Björkegren J. Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study. PLoS Genet. 2009 Dec; 5(12):e1000754.
    View in: PubMed
  8. Prokunina-Olsson L, Kaplan LM, Schadt EE, Collins FS. Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes. PLoS One. 2009; 4(9):e7231.
    View in: PubMed
  9. Stylopoulos N, Hoppin AG, Kaplan LM. Roux-en-Y gastric bypass enhances energy expenditure and extends lifespan in diet-induced obese rats. Obesity (Silver Spring). 2009 Oct; 17(10):1839-47.
    View in: PubMed
  10. Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum PY, Suver C, Chudin E, Kemp D, Reitman M, Voight BF, Neale BM, Schadt EE, Hirschhorn JN, Kaplan LM, Daly MJ. Common body mass index-associated variants confer risk of extreme obesity. Hum Mol Genet. 2009 Sep 15; 18(18):3502-7.
    View in: PubMed
  11. Bray GA, Bouchard C, Church TS, Cefalu WT, Greenway FL, Gupta AK, Kaplan LM, Ravussin E, Smith SR, Ryan DH. Is it time to change the way we report and discuss weight loss? Obesity (Silver Spring). 2009 Apr; 17(4):619-21.
    View in: PubMed
  12. Levine A, Ramos A, Escalona A, Rodriguez L, Greve JW, Janssen I, Rothstein R, Nepomnayshy D, Gersin KS, Melanson D, Lamport R, Fishman E, Malomo K, Kaplan LM, Neto MG. Radiographic appearance of endoscopic duodenal-jejunal bypass liner for treatment of obesity and type 2 diabetes. Surg Obes Relat Dis. 2009 May-Jun; 5(3):371-4.
    View in: PubMed
  13. Blackburn GL, Hutter MM, Harvey AM, Apovian CM, Boulton HR, Cummings S, Fallon JA, Greenberg I, Jiser ME, Jones DB, Jones SB, Kaplan LM, Kelly JJ, Kruger RS, Lautz DB, Lenders CM, Lonigro R, Luce H, McNamara A, Mulligan AT, Paasche-Orlow MK, Perna FM, Pratt JS, Riley SM, Robinson MK, Romanelli JR, Saltzman E, Schumann R, Shikora SA, Snow RL, Sogg S, Sullivan MA, Tarnoff M, Thompson CC, Wee CC, Ridley N, Auerbach J, Hu FB, Kirle L, Buckley RB, Annas CL. Expert panel on weight loss surgery: executive report update. Obesity (Silver Spring). 2009 May; 17(5):842-62.
    View in: PubMed
  14. Ellsmere JC, Thompson CC, Brugge WR, Chuttani R, J Desilets D, Rattner DW, E Tarnoff M, Kaplan LM. Endoscopic interventions for weight loss surgery. Obesity (Silver Spring). 2009 May; 17(5):929-33.
    View in: PubMed
  15. Shikora SA, Kruger RS, Blackburn GL, Fallon JA, Harvey AM, Johnson EQ, Kaplan L, Mun EC, Riley S, Robinson MK, Sabin JE, Snow RL, Lonigro R, Steingisser LJ, Lautz DB. Best practices in policy and access (coding and reimbursement) for weight loss surgery. Obesity (Silver Spring). 2009 May; 17(5):918-23.
    View in: PubMed
  16. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C, Burtt NP, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M, Ferrucci L, Scheet P, Sanna S, Uda M, Yang Q, Lunetta KL, Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS, Hercberg S, Meneton P, Lakatta EG, Scuteri A, Schlessinger D, Tuomilehto J, Collins FS, Groop L, Altshuler D, Collins R, Lathrop GM, Melander O, Salomaa V, Peltonen L, Orho-Melander M, Ordovas JM, Boehnke M, Abecasis GR, Mohlke KL, Cupples LA. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009 Jan; 41(1):56-65.
    View in: PubMed
  17. Hatoum IJ, Stein HK, Merrifield BF, Kaplan LM. Capacity for physical activity predicts weight loss after Roux-en-Y gastric bypass. Obesity (Silver Spring). 2009 Jan; 17(1):92-9.
    View in: PubMed
  18. Aguirre V, Stylopoulos N, Grinbaum R, Kaplan LM. An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity. Obesity (Silver Spring). 2008 Dec; 16(12):2585-92.
    View in: PubMed
  19. Kaplan LM, Ahmad NN. The cutting edge in diabetes treatment--is weight-loss surgery an effective therapeutic strategy? Nat Clin Pract Endocrinol Metab. 2008 Aug; 4(8):438-9.
    View in: PubMed
  20. Tarnoff M, Kaplan LM, Shikora S. An evidenced-based assessment of preoperative weight loss in bariatric surgery. Obes Surg. 2008 Sep; 18(9):1059-61.
    View in: PubMed
  21. Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y, Lally E, Weiss LA, Najm J, Kutsche K, Descartes M, Holt L, Braddock S, Troxell R, Kaplan L, Volkmar F, Klin A, Tsatsanis K, Harris DJ, Noens I, Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF. Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet. 2008 Jan; 82(1):199-207.
    View in: PubMed
  22. Kaplan LM, Klein S, Boden G, Brenner DA, Gostout CJ, Lavine JE, Popkin BM, Schirmer BD, Seeley RJ, Yanovski SZ, Cominelli F. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Gastroenterology. 2007 May; 132(6):2272-5.
    View in: PubMed
  23. Kaplan LM, Gorman MJ. Addressing the big challenge of obesity: how to prevent regain of lost weight. Nat Clin Pract Gastroenterol Hepatol. 2007 May; 4(5):254-5.
    View in: PubMed
  24. Hoppin AG, Katz ES, Kaplan LM, Lauwers GY. Case records of the Massachusetts General Hospital. Case 31-2006. A 15-year-old girl with severe obesity. N Engl J Med. 2006 Oct 12; 355(15):1593-602.
    View in: PubMed
  25. Stylopoulos N, Davis P, Pettit JD, Rattner DW, Kaplan LM. Changes in serum ghrelin predict weight loss after Roux-en-Y gastric bypass in rats. Surg Endosc. 2005 Jul; 19(7):942-6.
    View in: PubMed
  26. Fillingim RB, Kaplan L, Staud R, Ness TJ, Glover TL, Campbell CM, Mogil JS, Wallace MR. The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J Pain. 2005 Mar; 6(3):159-67.
    View in: PubMed
  27. Kaplan LM. Pharmacological therapies for obesity. Gastroenterol Clin North Am. 2005 Mar; 34(1):91-104.
    View in: PubMed
  28. Kaplan LM. Gastrointestinal management of the bariatric surgery patient. Gastroenterol Clin North Am. 2005 Mar; 34(1):105-25.
    View in: PubMed
  29. Kaplan LM, Fallon JA, Mun EC, Harvey AM, Kastrinakis WV, Johnson EQ, Nierman RS, Keroack CR. Coding and reimbursement for weight loss surgery: best practice recommendations. Obes Res. 2005 Feb; 13(2):290-300.
    View in: PubMed
  30. Pratt JS, Cummings S, Vineberg DA, Graeme-Cook F, Kaplan LM. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 25-2004. A 49-year-old woman with severe obesity, diabetes, and hypertension. N Engl J Med. 2004 Aug 12; 351(7):696-705.
    View in: PubMed
  31. Kaplan LM. Body weight regulation and obesity. J Gastrointest Surg. 2003 May-Jun; 7(4):443-51.
    View in: PubMed
  32. Mogil JS, Wilson SG, Chesler EJ, Rankin AL, Nemmani KV, Lariviere WR, Groce MK, Wallace MR, Kaplan L, Staud R, Ness TJ, Glover TL, Stankova M, Mayorov A, Hruby VJ, Grisel JE, Fillingim RB. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4867-72.
    View in: PubMed
  33. Hoppin AG, Kaplan LM. The leptin era: new insight into the mechanisms of body weight homeostasis. J Pediatr Gastroenterol Nutr. 1999 Sep; 29(3):250-64.
    View in: PubMed
  34. Chung RT, Monto A, Dienstag JL, Kaplan LM. Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus. J Med Virol. 1999 Aug; 58(4):353-8.
    View in: PubMed
  35. Chung RT, Kaplan LM. Heterogeneous nuclear ribonucleoprotein I (hnRNP-I/PTB) selectively binds the conserved 3' terminus of hepatitis C viral RNA. Biochem Biophys Res Commun. 1999 Jan 19; 254(2):351-62.
    View in: PubMed
  36. Kaplan LM. Leptin, obesity, and liver disease. Gastroenterology. 1998 Oct; 115(4):997-1001.
    View in: PubMed
  37. Epstein SK, Zilberberg MD, Jacoby C, Ciubotaru RL, Kaplan LM. Response to symptom-limited exercise in patients with the hepatopulmonary syndrome. Chest. 1998 Sep; 114(3):736-41.
    View in: PubMed
  38. Epstein SK, Ciubotaru RL, Zilberberg MD, Kaplan LM, Jacoby C, Freeman R, Kaplan MM. Analysis of impaired exercise capacity in patients with cirrhosis. Dig Dis Sci. 1998 Aug; 43(8):1701-7.
    View in: PubMed
  39. Patel BK, Koenig JI, Kaplan LM, Hooi SC. Increase in plasma leptin and Lep mRNA concentrations by food intake is dependent on insulin. Metabolism. 1998 May; 47(5):603-7.
    View in: PubMed
  40. Hoppin AG, Kaplan LM, Zurakowski D, Leichtner AM, Bousvaros A. Serum leptin in children and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1998 May; 26(5):500-5.
    View in: PubMed
  41. Kaplan LM, Epstein SK, Schwartz SL, Cao QL, Pandian NG. Clinical, echocardiographic, and hemodynamic evidence of cardiac tamponade caused by large pleural effusions. Am J Respir Crit Care Med. 1995 Mar; 151(3 Pt 1):904-8.
    View in: PubMed
  42. Richter JM, Christensen MR, Kaplan LM, Nishioka NS. Effectiveness of current technology in the diagnosis and management of lower gastrointestinal hemorrhage. Gastrointest Endosc. 1995 Feb; 41(2):93-8.
    View in: PubMed
  43. Chung RT, Kaplan LM. Parenterally transmitted hepatitis: viruses, vaccines, and antiviral therapy. Compr Ther. 1993; 19(4):163-73.
    View in: PubMed
  44. Agnello V, Chung RT, Kaplan LM. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med. 1992 Nov 19; 327(21):1490-5.
    View in: PubMed
  45. Hsu DW, Hooi SC, Hedley-Whyte ET, Strauss RM, Kaplan LM. Coexpression of galanin and adrenocorticotropic hormone in human pituitary and pituitary adenomas. Am J Pathol. 1991 Apr; 138(4):897-909.
    View in: PubMed
  46. Hsu DW, el-Azouzi M, Black PM, Chin WW, Hedley-Whyte ET, Kaplan LM. Estrogen increases galanin immunoreactivity in hyperplastic prolactin-secreting cells in Fisher 344 rats. Endocrinology. 1990 Jun; 126(6):3159-67.
    View in: PubMed
  47. Kaplan LM, Gabriel SM, Koenig JI, Sunday ME, Spindel ER, Martin JB, Chin WW. Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7408-12.
    View in: PubMed
  48. Kaplan LM, Spindel ER, Isselbacher KJ, Chin WW. Tissue-specific expression of the rat galanin gene. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1065-9.
    View in: PubMed
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