Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Dennis Brown, PH.D.

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Program in Membrane Biology, Simches Research Center
185 Cambridge St
Boston MA 02114
Phone617/726-5665
Fax617/643-3182

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
PMB Microscopy Core (MGH) - Core services (12), Instruments (17) and Software (2)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Brown D, Jenny Lu HA. Aquaporin-2 inhibitors: fishing in the chemical pool. J Am Soc Nephrol. 2013 Apr; 24(5):685-6.
    View in: PubMed
  2. Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D. Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel. Am J Physiol Cell Physiol. 2013 Jan; 304(1):C38-48.
    View in: PubMed
  3. Brown D, Bouley R, Paunescu TG, Breton S, Lu HA. New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells. Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1421-33.
    View in: PubMed
  4. Brown D, Wagner CA. Molecular mechanisms of acid-base sensing by the kidney. J Am Soc Nephrol. 2012 May; 23(5):774-80.
    View in: PubMed
  5. Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R. Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand. Endocrinology. 2011 Oct; 152(10):3893-904.
    View in: PubMed
  6. Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA. Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase. Am J Physiol Renal Physiol. 2011 Aug; 301(2):F309-18.
    View in: PubMed
  7. Shum WW, Da Silva N, Belleannée C, McKee M, Brown D, Breton S. Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells. Am J Physiol Cell Physiol. 2011 Jul; 301(1):C31-43.
    View in: PubMed
  8. Da Silva N, Cortez-Retamozo V, Reinecker HC, Wildgruber M, Hill E, Brown D, Swirski FK, Pittet MJ, Breton S. A dense network of dendritic cells populates the murine epididymis. Reproduction. 2011 May; 141(5):653-63.
    View in: PubMed
  9. Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello DA, Marshansky V. Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution. Am J Physiol Cell Physiol. 2011 Jun; 300(6):C1442-55.
    View in: PubMed
  10. Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D. Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration. J Am Soc Nephrol. 2011 Jan; 22(1):59-72.
    View in: PubMed
  11. Zhuang Z, Marshansky V, Breton S, Brown D. Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situ. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F199-206.
    View in: PubMed
  12. Miranda KC, Bond DT, McKee M, Skog J, Paunescu TG, Da Silva N, Brown D, Russo LM. Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease. Kidney Int. 2010 Jul; 78(2):191-9.
    View in: PubMed
  13. Miranda KC, Karet FE, Brown D. An extended nomenclature for mammalian V-ATPase subunit genes and splice variants. PLoS One. 2010; 5(3):e9531.
    View in: PubMed
  14. Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol. 2010 Apr; 21(4):666-77.
    View in: PubMed
  15. Belleannée C, Da Silva N, Shum WW, Brown D, Breton S. Role of purinergic signaling pathways in V-ATPase recruitment to apical membrane of acidifying epididymal clear cells. Am J Physiol Cell Physiol. 2010 Apr; 298(4):C817-30.
    View in: PubMed
  16. Paunescu TG, Ljubojevic M, Russo LM, Winter C, McLaughlin MM, Wagner CA, Breton S, Brown D. cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F643-54.
    View in: PubMed
  17. Pastor-Soler NM, Fisher JS, Sharpe R, Hill E, Van Hoek A, Brown D, Breton S. Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones. Reproduction. 2010 Mar; 139(3):613-21.
    View in: PubMed
  18. Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF. Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1575-86.
    View in: PubMed
  19. Shum WW, Da Silva N, Brown D, Breton S. Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk. J Exp Biol. 2009 Jun; 212(Pt 11):1753-61.
    View in: PubMed
  20. Brown D, Paunescu TG, Breton S, Marshansky V. Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking. J Exp Biol. 2009 Jun; 212(Pt 11):1762-72.
    View in: PubMed
  21. Brown D, Breton S, Ausiello DA, Marshansky V. Sensing, signaling and sorting events in kidney epithelial cell physiology. Traffic. 2009 Mar; 10(3):275-84.
    View in: PubMed
  22. Russo LM, Sandoval RM, Campos SB, Molitoris BA, Comper WD, Brown D. Impaired tubular uptake explains albuminuria in early diabetic nephropathy. J Am Soc Nephrol. 2009 Mar; 20(3):489-94.
    View in: PubMed
  23. Shum WW, Da Silva N, McKee M, Smith PJ, Brown D, Breton S. Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia. Cell. 2008 Dec 12; 135(6):1108-17.
    View in: PubMed
  24. Belleannée C, Da Silva N, Shum WW, Marsolais M, Laprade R, Brown D, Breton S. Segmental expression of the bradykinin type 2 receptor in rat efferent ducts and epididymis and its role in the regulation of aquaporin 9. Biol Reprod. 2009 Jan; 80(1):134-43.
    View in: PubMed
  25. Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D. A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2. Am J Physiol Cell Physiol. 2008 Dec; 295(6):C1476-87.
    View in: PubMed
  26. Brown D, Hasler U, Nunes P, Bouley R, Lu HA. Phosphorylation events and the modulation of aquaporin 2 cell surface expression. Curr Opin Nephrol Hypertens. 2008 Sep; 17(5):491-8.
    View in: PubMed
  27. Paunescu TG, Jones AC, Tyszkowski R, Brown D. V-ATPase expression in the mouse olfactory epithelium. Am J Physiol Cell Physiol. 2008 Oct; 295(4):C923-30.
    View in: PubMed
  28. Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D. Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells. J Biol Chem. 2008 Sep 26; 283(39):26643-61.
    View in: PubMed
  29. Bouley R, Hasler U, Lu HA, Nunes P, Brown D. Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus. Semin Nephrol. 2008 May; 28(3):266-78.
    View in: PubMed
  30. Brown D. Aquaporins and vasopressin signaling in kidney health and disease: introduction. Semin Nephrol. 2008 May; 28(3):215-6.
    View in: PubMed
  31. Lu HJ, Matsuzaki T, Bouley R, Hasler U, Qin QH, Brown D. The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F290-4.
    View in: PubMed
  32. Lu L, Bao Y, Khan A, Goldstein AM, Newburg DS, Quaroni A, Brown D, Walker WA. Hydrocortisone modulates cholera toxin endocytosis by regulating immature enterocyte plasma membrane phospholipids. Gastroenterology. 2008 Jul; 135(1):185-193.e1.
    View in: PubMed
  33. Russo LM, Brown D, Lin HY. The soluble transforming growth factor-beta receptor: advantages and applications. Int J Biochem Cell Biol. 2009 Mar; 41(3):472-6.
    View in: PubMed
  34. Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 1; 283(5):2986-96.
    View in: PubMed
  35. Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D. Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jan; 294(1):F130-8.
    View in: PubMed
  36. Paunescu TG, Russo LM, Da Silva N, Kovacikova J, Mohebbi N, Van Hoek AN, McKee M, Wagner CA, Breton S, Brown D. Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice. Am J Physiol Renal Physiol. 2007 Dec; 293(6):F1915-26.
    View in: PubMed
  37. Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD. Controversies in nephrology: response to 'renal albumin handling, facts, and artifacts'. Kidney Int. 2007 Nov; 72(10):1195-7.
    View in: PubMed
  38. Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. J Biol Chem. 2007 Sep 28; 282(39):28721-32.
    View in: PubMed
  39. Da Silva N, Shum WW, El-Annan J, Paunescu TG, McKee M, Smith PJ, Brown D, Breton S. Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C199-210.
    View in: PubMed
  40. Russo LM, del Re E, Brown D, Lin HY. Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor. Diabetes. 2007 Feb; 56(2):380-8.
    View in: PubMed
  41. Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int. 2007 Mar; 71(6):504-13.
    View in: PubMed
  42. Breton S, Brown D. New insights into the regulation of V-ATPase-dependent proton secretion. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F1-10.
    View in: PubMed
  43. Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K. In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates. Nano Lett. 2006 Oct; 6(10):2225-31.
    View in: PubMed
  44. Da Silva N, Piétrement C, Brown D, Breton S. Segmental and cellular expression of aquaporins in the male excurrent duct. Biochim Biophys Acta. 2006 Aug; 1758(8):1025-33.
    View in: PubMed
  45. Bouley R, Hawthorn G, Russo LM, Lin HY, Ausiello DA, Brown D. Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell. 2006 Apr; 98(4):215-32.
    View in: PubMed
  46. Brown D. Imaging protein trafficking. Nephron Exp Nephrol. 2006; 103(2):e55-61.
    View in: PubMed
  47. Russo LM, McKee M, Brown D. Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney. Am J Physiol Renal Physiol. 2006 Jul; 291(1):F246-53.
    View in: PubMed
  48. Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat Cell Biol. 2006 Feb; 8(2):124-36.
    View in: PubMed
  49. Da Silva N, Silberstein C, Beaulieu V, Piétrement C, Van Hoek AN, Brown D, Breton S. Postnatal expression of aquaporins in epithelial cells of the rat epididymis. Biol Reprod. 2006 Feb; 74(2):427-38.
    View in: PubMed
  50. Pietrement C, Sun-Wada GH, Silva ND, McKee M, Marshansky V, Brown D, Futai M, Breton S. Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis. Biol Reprod. 2006 Jan; 74(1):185-94.
    View in: PubMed
  51. Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP. The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13616-21.
    View in: PubMed
  52. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95.
    View in: PubMed
  53. Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005 Jul; 37(7):739-44.
    View in: PubMed
  54. Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA. Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1390-401.
    View in: PubMed
  55. Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12.
    View in: PubMed
  56. Miller RL, Zhang P, Smith M, Beaulieu V, Paunescu TG, Brown D, Breton S, Nelson RD. V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice. Am J Physiol Cell Physiol. 2005 May; 288(5):C1134-44.
    View in: PubMed
  57. Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 4; 280(9):8452-63.
    View in: PubMed
  58. Kahle KT, Macgregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP. Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14877-82.
    View in: PubMed
  59. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Renal vacuolar H+-ATPase. Physiol Rev. 2004 Oct; 84(4):1263-314.
    View in: PubMed
  60. Paredes AM, Ferreira D, Horton M, Saad A, Tsuruta H, Johnston R, Klimstra W, Ryman K, Hernandez R, Chiu W, Brown DT. Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion. Virology. 2004 Jul 1; 324(2):373-86.
    View in: PubMed
  61. Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, Van Hoek AN. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11.
    View in: PubMed
  62. Fujita Y, Terashima M, Kakuta T, Itoh J, Tokimasa T, Brown D, Saito A. Transcellular water transport and stability of expression in aquaporin 1-transfected LLC-PK1 cells in the development of a portable bioartificial renal tubule device. Tissue Eng. 2004 May-Jun; 10(5-6):711-22.
    View in: PubMed
  63. Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D. Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C149-62.
    View in: PubMed
  64. El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. Am J Physiol Cell Physiol. 2004 Apr; 286(4):C768-78.
    View in: PubMed
  65. Smith AN, Lovering RC, Futai M, Takeda J, Brown D, Karet FE. Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes. Mol Cell. 2003 Oct; 12(4):801-3.
    View in: PubMed
  66. Lu H, Sun TX, Bouley R, Blackburn K, McLaughlin M, Brown D. Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2. Am J Physiol Renal Physiol. 2004 Feb; 286(2):F233-43.
    View in: PubMed
  67. Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 5; 278(49):49523-9.
    View in: PubMed
  68. Ba J, Brown D, Friedman PA. Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1233-43.
    View in: PubMed
  69. Pearson AM, Baksa K, Rämet M, Protas M, McKee M, Brown D, Ezekowitz RA. Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Microbes Infect. 2003 Aug; 5(10):815-24.
    View in: PubMed
  70. Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC, Gerber HP, Ferrara N, Melton DA. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol. 2003 Jun 17; 13(12):1070-4.
    View in: PubMed
  71. Bouley R, Sun TX, Chenard M, McLaughlin M, McKee M, Lin HY, Brown D, Ausiello DA. Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C750-62.
    View in: PubMed
  72. Wagner CA, Lükewille U, Valles P, Breton S, Brown D, Giebisch GH, Geibel JP. A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse. Pflugers Arch. 2003 Aug; 446(5):623-32.
    View in: PubMed
  73. Brown D. The ins and outs of aquaporin-2 trafficking. Am J Physiol Renal Physiol. 2003 May; 284(5):F893-901.
    View in: PubMed
  74. Isnard-Bagnis C, Da Silva N, Beaulieu V, Yu AS, Brown D, Breton S. Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C220-32.
    View in: PubMed
  75. Zharkikh L, Zhu X, Stricklett PK, Kohan DE, Chipman G, Breton S, Brown D, Nelson RD. Renal principal cell-specific expression of green fluorescent protein in transgenic mice. Am J Physiol Renal Physiol. 2002 Dec; 283(6):F1351-64.
    View in: PubMed
  76. Sabolic I, Ljubojevic M, Herak-Kramberger CM, Brown D. Cd-MT causes endocytosis of brush-border transporters in rat renal proximal tubules. Am J Physiol Renal Physiol. 2002 Dec; 283(6):F1389-402.
    View in: PubMed
  77. van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7.
    View in: PubMed
  78. Marshansky V, Ausiello DA, Brown D. Physiological importance of endosomal acidification: potential role in proximal tubulopathies. Curr Opin Nephrol Hypertens. 2002 Sep; 11(5):527-37.
    View in: PubMed
  79. Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002 Jun; 66(6):1716-22.
    View in: PubMed
  80. Sun TX, Van Hoek A, Huang Y, Bouley R, McLaughlin M, Brown D. Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F998-1011.
    View in: PubMed
  81. Christmas P, Weber BM, McKee M, Brown D, Soberman RJ. Membrane localization and topology of leukotriene C4 synthase. J Biol Chem. 2002 Aug 9; 277(32):28902-8.
    View in: PubMed
  82. Sabolic I, Herak-Kramberger CM, Ljubojevic M, Biemesderfer D, Brown D. NHE3 and NHERF are targeted to the basolateral membrane in proximal tubules of colchicine-treated rats. Kidney Int. 2002 Apr; 61(4):1351-64.
    View in: PubMed
  83. Breton S, Inoue T, Knepper MA, Brown D. Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia. Am J Physiol Renal Physiol. 2002 Mar; 282(3):F523-9.
    View in: PubMed
  84. Cario E, Brown D, McKee M, Lynch-Devaney K, Gerken G, Podolsky DK. Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am J Pathol. 2002 Jan; 160(1):165-73.
    View in: PubMed
  85. Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W. Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments. Brain Res Mol Brain Res. 2001 Nov 30; 96(1-2):14-20.
    View in: PubMed
  86. Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D. Aquaporin 9 expression along the male reproductive tract. Biol Reprod. 2001 Aug; 65(2):384-93.
    View in: PubMed
  87. Herak-Kramberger CM, Breton S, Brown D, Kraus O, Sabolic I. Distribution of the vacuolar H+ atpase along the rat and human male reproductive tract. Biol Reprod. 2001 Jun; 64(6):1699-707.
    View in: PubMed
  88. Herak-Kramberger CM, Sabolic I, Blanusa M, Smith PJ, Brown D, Breton S. Cadmium inhibits vacuolar H(+)ATPase-mediated acidification in the rat epididymis. Biol Reprod. 2000 Aug; 63(2):599-606.
    View in: PubMed
  89. Breton S, Nsumu NN, Galli T, Sabolic I, Smith PJ, Brown D. Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract. Am J Physiol Renal Physiol. 2000 May; 278(5):F717-25.
    View in: PubMed
  90. Baus M, Medjugorac-Popovski M, Brown D, Sabolic I, Mirela B, Mila MP, Ivan S. In colchicine-treated rats, cellular distribution of AQP-1 in convoluted and straight proximal tubule segments is differently affected. Pflugers Arch. 2000 Jan; 439(3):321-30.
    View in: PubMed
  91. Sabolic I, Herak-Kramberger CM, Breton S, Brown D. Na/K-ATPase in intercalated cells along the rat nephron revealed by antigen retrieval. J Am Soc Nephrol. 1999 May; 10(5):913-22.
    View in: PubMed
  92. Breton S, Tyszkowski R, Sabolic I, Brown D. Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis. Histochem Cell Biol. 1999 Feb; 111(2):97-105.
    View in: PubMed
  93. Herak-Kramberger CM, Brown D, Sabolic I. Cadmium inhibits vacuolar H(+)-ATPase and endocytosis in rat kidney cortex. Kidney Int. 1998 Jun; 53(6):1713-26.
    View in: PubMed
  94. Brown D, Sabolic I, Breton S. Polarized expression of membrane proteins in renal epithelial cells: involvement of specialized transport vesicles and intracellular pathways. Adv Nephrol Necker Hosp. 1997; 27:297-315.
    View in: PubMed
  95. Sabolic I, Brown D, Gluck SL, Alper SL. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int. 1997 Jan; 51(1):125-37.
    View in: PubMed
  96. Sabolic I, Brown D, Barckhardt T. Ecto-ATPase activity and labeling with the anti-ecto-ATPase antibody in renal brush border do not coincide. Am J Physiol. 1996 Nov; 271(5 Pt 2):F1100-1.
    View in: PubMed
  97. Brown D, Katsura T, Kawashima M, Verkman AS, Sabolic I. Cellular distribution of the aquaporins: a family of water channel proteins. Histochem Cell Biol. 1995 Jul; 104(1):1-9.
    View in: PubMed
  98. Schweickhardt C, Sabolic I, Brown D, Burckhardt G. Ecto-adenosinetriphosphatase in rat small intestinal brush-border membranes. Am J Physiol. 1995 Apr; 268(4 Pt 1):G663-72.
    View in: PubMed
  99. Bachinsky DR, Sabolic I, Emmanouel DS, Jefferson DM, Carone FA, Brown D, Perrone RD. Water channel expression in human ADPKD kidneys. Am J Physiol. 1995 Mar; 268(3 Pt 2):F398.
    View in: PubMed
  100. Sabolic I, Katsura T, Verbavatz JM, Brown D. The AQP2 water channel: effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats. J Membr Biol. 1995 Feb; 143(3):165-75.
    View in: PubMed
  101. Valenti G, Verbavatz JM, Sabolic I, Ausiello DA, Verkman AS, Brown D. A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells. Am J Physiol. 1994 Sep; 267(3 Pt 1):C812-20.
    View in: PubMed
  102. Sabolic I, Brown D. Water transport in renal tubules is mediated by aquaporins. Clin Investig. 1994 Sep; 72(9):698-700.
    View in: PubMed
  103. Sabolic I, Brown D, Verbavatz JM, Kleinman J. H(+)-ATPases of renal cortical and medullary endosomes are differentially sensitive to Sch-28080 and omeprazole. Am J Physiol. 1994 Jun; 266(6 Pt 2):F868-77.
    View in: PubMed
  104. Verbavatz JM, Van Hoek AN, Ma T, Sabolic I, Valenti G, Ellisman MH, Ausiello DA, Verkman AS, Brown D. A 28 kDa sarcolemmal antigen in kidney principal cell basolateral membranes: relationship to orthogonal arrays and MIP26. J Cell Sci. 1994 Apr; 107 ( Pt 4):1083-94.
    View in: PubMed
  105. Verbavatz JM, Brown D, Sabolic I, Valenti G, Ausiello DA, Van Hoek AN, Ma T, Verkman AS. Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. J Cell Biol. 1993 Nov; 123(3):605-18.
    View in: PubMed
  106. Brown D, Verbavatz JM, Valenti G, Lui B, Sabolic I. Localization of the CHIP28 water channel in reabsorptive segments of the rat male reproductive tract. Eur J Cell Biol. 1993 Aug; 61(2):264-73.
    View in: PubMed
  107. Brown D, Sabolic I. Endosomal pathways for water channel and proton pump recycling in kidney epithelial cells. J Cell Sci Suppl. 1993; 17:49-59.
    View in: PubMed
  108. Sabolic I, Valenti G, Verbavatz JM, Van Hoek AN, Verkman AS, Ausiello DA, Brown D. Localization of the CHIP28 water channel in rat kidney. Am J Physiol. 1992 Dec; 263(6 Pt 1):C1225-33.
    View in: PubMed
  109. Brown D, Sabolic I, Gluck S. Polarized targeting of V-ATPase in kidney epithelial cells. J Exp Biol. 1992 Nov; 172:231-43.
    View in: PubMed
  110. Sabolic I, Wuarin F, Shi LB, Verkman AS, Ausiello DA, Gluck S, Brown D. Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping ATPase. J Cell Biol. 1992 Oct; 119(1):111-22.
    View in: PubMed
  111. Brown D, Lui B, Gluck S, Sabolic I. A plasma membrane proton ATPase in specialized cells of rat epididymis. Am J Physiol. 1992 Oct; 263(4 Pt 1):C913-6.
    View in: PubMed
  112. Sabolic I, Culic O, Lin SH, Brown D. Localization of ecto-ATPase in rat kidney and isolated renal cortical membrane vesicles. Am J Physiol. 1992 Feb; 262(2 Pt 2):F217-28.
    View in: PubMed
  113. Sabolic I, Shi LB, Brown D, Ausiello DA, Verkman AS. Proteinases inhibit H(+)-ATPase and Na+/H+ exchange but not water transport in apical and endosomal membranes from rat proximal tubule. Biochim Biophys Acta. 1992 Jan 10; 1103(1):137-47.
    View in: PubMed
  114. Stow JL, Sabolic I, Brown D. Heterogeneous localization of G protein alpha-subunits in rat kidney. Am J Physiol. 1991 Nov; 261(5 Pt 2):F831-40.
    View in: PubMed
  115. Brown D, Sabolic I, Gluck S. Colchicine-induced redistribution of proton pumps in kidney epithelial cells. Kidney Int Suppl. 1991 Jul; 33:S79-83.
    View in: PubMed
  116. Sabolic I, Brown D. Na+(Li+)-H+ exchange in rat renal cortical vesicles with endosomal characteristics. Am J Physiol. 1990 May; 258(5 Pt 2):F1245-53.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Brown's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_