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David Bruce Mount, M.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBoston Va Med Ctr-W Roxbury
1400 Vfw Parkway
West Roxbury MA 02132
Phone617/525-5876
Fax617/525-5830

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mount DB. The kidney in hyperuricemia and gout. Curr Opin Nephrol Hypertens. 2013 Mar; 22(2):216-23.
    View in: PubMed
  2. Toka HR, Al-Romaih K, Koshy JM, Dibartolo S, Kos CH, Quinn SJ, Curhan GC, Mount DB, Brown EM, Pollak MR. Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol. 2012 Nov; 23(11):1879-90.
    View in: PubMed
  3. Acton BA, Mahadevan V, Mercado A, Uvarov P, Ding Y, Pressey J, Airaksinen MS, Mount DB, Woodin MA. Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain. J Neurosci. 2012 Jun 20; 32(25):8746-51.
    View in: PubMed
  4. Pan D, Kalfa TA, Wang D, Risinger M, Crable S, Ottlinger A, Chandra S, Mount DB, Hübner CA, Franco RS, Joiner CH. K-Cl cotransporter gene expression during human and murine erythroid differentiation. J Biol Chem. 2011 Sep 2; 286(35):30492-503.
    View in: PubMed
  5. Taylor EN, Stampfer MJ, Mount DB, Curhan GC. DASH-style diet and 24-hour urine composition. Clin J Am Soc Nephrol. 2010 Dec; 5(12):2315-22.
    View in: PubMed
  6. Hartmann AM, Wenz M, Mercado A, Störger C, Mount DB, Friauf E, Nothwang HG. Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4. J Biol Chem. 2010 Jul 30; 285(31):23994-4002.
    View in: PubMed
  7. Mount DB. Regulated endocytosis of NCC. Am J Physiol Renal Physiol. 2010 Aug; 299(2):F297-9.
    View in: PubMed
  8. Choi HK, Zhu Y, Mount DB. Genetics of gout. Curr Opin Rheumatol. 2010 Mar; 22(2):144-51.
    View in: PubMed
  9. Belenky MA, Sollars PJ, Mount DB, Alper SL, Yarom Y, Pickard GE. Cell-type specific distribution of chloride transporters in the rat suprachiasmatic nucleus. Neuroscience. 2010 Feb 17; 165(4):1519-37.
    View in: PubMed
  10. Chen YF, Chou CY, Wilkins RJ, Ellory JC, Mount DB, Shen MR. Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion. Cancer Res. 2009 Nov 15; 69(22):8585-93.
    View in: PubMed
  11. Hekmat-Scafe DS, Mercado A, Fajilan AA, Lee AW, Hsu R, Mount DB, Tanouye MA. Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain. Genetics. 2010 Jan; 184(1):171-83.
    View in: PubMed
  12. Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med. 2009 Sep; 122(9):857-65.
    View in: PubMed
  13. Chang MH, Plata C, Sindic A, Ranatunga WK, Chen AP, Zandi-Nejad K, Chan KW, Thompson J, Mount DB, Romero MF. Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain. J Biol Chem. 2009 Oct 9; 284(41):28306-18.
    View in: PubMed
  14. Mount DB. Splicing a kinase and the regulation of salt transport. J Am Soc Nephrol. 2009 Jun; 20(6):1166-8.
    View in: PubMed
  15. Mount DB, Krahn TA. Hyponatremia: case vignettes. Semin Nephrol. 2009 May; 29(3):300-17.
    View in: PubMed
  16. Mount DB. The brain in hyponatremia: both culprit and victim. Semin Nephrol. 2009 May; 29(3):196-215.
    View in: PubMed
  17. Mount DB. Hyponatremia: introduction. Semin Nephrol. 2009 May; 29(3):175-7.
    View in: PubMed
  18. Chang MH, Plata C, Zandi-Nejad K, Sindic A, Sussman CR, Mercado A, Broumand V, Raghuram V, Mount DB, Romero MF. Slc26a9--anion exchanger, channel and Na+ transporter. J Membr Biol. 2009 Apr; 228(3):125-40.
    View in: PubMed
  19. Kahle KT, Staley KJ, Nahed BV, Gamba G, Hebert SC, Lifton RP, Mount DB. Roles of the cation-chloride cotransporters in neurological disease. Nat Clin Pract Neurol. 2008 Sep; 4(9):490-503.
    View in: PubMed
  20. Simão S, Pedrosa R, Hopfer U, Mount DB, Jose PA, Soares-da-Silva P. Short-term regulation of the Cl-/HCO3(-) exchanger in immortalized SHR proximal tubular epithelial cells. Biochem Pharmacol. 2008 Jun 1; 75(11):2224-33.
    View in: PubMed
  21. Jiao Y, Jin X, Yan J, Zhang C, Jiao F, Li X, Roe BA, Mount DB, Gu W. A deletion mutation in Slc12a6 is associated with neuromuscular disease in gaxp mice. Genomics. 2008 May; 91(5):407-14.
    View in: PubMed
  22. Reynolds A, Brustein E, Liao M, Mercado A, Babilonia E, Mount DB, Drapeau P. Neurogenic role of the depolarizing chloride gradient revealed by global overexpression of KCC2 from the onset of development. J Neurosci. 2008 Feb 13; 28(7):1588-97.
    View in: PubMed
  23. Sindic A, Chang MH, Mount DB, Romero MF. Renal physiology of SLC26 anion exchangers. Curr Opin Nephrol Hypertens. 2007 Sep; 16(5):484-90.
    View in: PubMed
  24. Mount DB. Collectrin and the kidney. Curr Opin Nephrol Hypertens. 2007 Sep; 16(5):427-9.
    View in: PubMed
  25. Plata C, Sussman CR, Sindic A, Liang JO, Mount DB, Josephs ZM, Chang MH, Romero MF. Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8). J Biol Chem. 2007 Apr 20; 282(16):11996-2009.
    View in: PubMed
  26. Mount DB, Kwon CY, Zandi-Nejad K. Renal urate transport. Rheum Dis Clin North Am. 2006 May; 32(2):313-31, vi.
    View in: PubMed
  27. Taylor EN, Mount DB, Forman JP, Curhan GC. Association of prevalent hypertension with 24-hour urinary excretion of calcium, citrate, and other factors. Am J Kidney Dis. 2006 May; 47(5):780-9.
    View in: PubMed
  28. Mount DB. Membrane trafficking and the regulation of NKCC2. Am J Physiol Renal Physiol. 2006 Mar; 290(3):F606-7.
    View in: PubMed
  29. de Los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vázquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G. WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc Natl Acad Sci U S A. 2006 Feb 7; 103(6):1976-81.
    View in: PubMed
  30. Romero MF, Chang MH, Plata C, Zandi-Nejad K, Mercado A, Broumand V, Sussman CR, Mount DB. Physiology of electrogenic SLC26 paralogues. Novartis Found Symp. 2006; 273:126-38; discussion 138-47, 261-4.
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  31. Fraga S, Luo Y, Jose P, Zandi-Nejad K, Mount DB, Soares-da-Silva P. Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6). Cell Physiol Biochem. 2006; 18(6):347-60.
    View in: PubMed
  32. Mercado A, Broumand V, Zandi-Nejad K, Enck AH, Mount DB. A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport. J Biol Chem. 2006 Jan 13; 281(2):1016-26.
    View in: PubMed
  33. Choi HK, Mount DB, Reginato AM. Pathogenesis of gout. Ann Intern Med. 2005 Oct 4; 143(7):499-516.
    View in: PubMed
  34. Mount DB. Molecular physiology and the four-component model of renal urate transport. Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):460-3.
    View in: PubMed
  35. Mercado A, Vázquez N, Song L, Cortés R, Enck AH, Welch R, Delpire E, Gamba G, Mount DB. NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter. Am J Physiol Renal Physiol. 2005 Dec; 289(6):F1246-61.
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  36. Nakada T, Zandi-Nejad K, Kurita Y, Kudo H, Broumand V, Kwon CY, Mercado A, Mount DB, Hirose S. Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater. Am J Physiol Regul Integr Comp Physiol. 2005 Aug; 289(2):R575-R585.
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  37. Mount DB. Novel physiology for an orphan transporter. Curr Opin Nephrol Hypertens. 2004 Sep; 13(5):521-3.
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  38. Karadsheh MF, Byun N, Mount DB, Delpire E. Localization of the KCC4 potassium-chloride cotransporter in the nervous system. Neuroscience. 2004; 123(2):381-91.
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  39. Mercado A, Mount DB, Gamba G. Electroneutral cation-chloride cotransporters in the central nervous system. Neurochem Res. 2004 Jan; 29(1):17-25.
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  40. Mercado A, Gamba G, Mount DB. Molecular physiology of mammalian K(+)-Cl- cotransporters. Adv Exp Med Biol. 2004; 559:29-41.
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  41. Chauhan S, Pandey R, Way JF, Sroka TC, Demetriou MC, Kunz S, Cress AE, Mount DW, Miesfeld RL. Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation. Biochem Biophys Res Commun. 2003 Oct 17; 310(2):421-32.
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  42. Mount DB, Romero MF. The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch. 2004 Feb; 447(5):710-21.
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  43. Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Pflugers Arch. 2004 Feb; 447(5):580-93.
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  44. Gallazzini M, Attmane-Elakeb A, Mount DB, Hebert SC, Bichara M. Regulation by glucocorticoids and osmolality of expression of ROMK (Kir 1.1), the apical K channel of thick ascending limb. Am J Physiol Renal Physiol. 2003 May; 284(5):F977-86.
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  45. Pandey R, Müller A, Napoli CA, Selinger DA, Pikaard CS, Richards EJ, Bender J, Mount DW, Jorgensen RA. Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Nucleic Acids Res. 2002 Dec 1; 30(23):5036-55.
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  46. Howard HC, Mount DB, Rochefort D, Byun N, Dupré N, Lu J, Fan X, Song L, Rivière JB, Prévost C, Horst J, Simonati A, Lemcke B, Welch R, England R, Zhan FQ, Mercado A, Siesser WB, George AL, McDonald MP, Bouchard JP, Mathieu J, Delpire E, Rouleau GA. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet. 2002 Nov; 32(3):384-92.
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  47. Xie Q, Welch R, Mercado A, Romero MF, Mount DB. Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. Am J Physiol Renal Physiol. 2002 Oct; 283(4):F826-38.
    View in: PubMed
  48. Song L, Mercado A, Vázquez N, Xie Q, Desai R, George AL, Gamba G, Mount DB. Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. Brain Res Mol Brain Res. 2002 Jun 30; 103(1-2):91-105.
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  49. Woo NS, Lu J, England R, McClellan R, Dufour S, Mount DB, Deutch AY, Lovinger DM, Delpire E. Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus. 2002; 12(2):258-68.
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  50. Delpire E, Mount DB. Human and murine phenotypes associated with defects in cation-chloride cotransport. Annu Rev Physiol. 2002; 64:803-43.
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  51. Lauf PK, Zhang J, Delpire E, Fyffe RE, Mount DB, Adragna NC. K-Cl co-transport: immunocytochemical and functional evidence for more than one KCC isoform in high K and low K sheep erythrocytes. Comp Biochem Physiol A Mol Integr Physiol. 2001 Oct; 130(3):499-509.
    View in: PubMed
  52. Mount DB, Gamba G. Renal potassium-chloride cotransporters. Curr Opin Nephrol Hypertens. 2001 Sep; 10(5):685-91.
    View in: PubMed
  53. Mercado A, de los Heros P, Vázquez N, Meade P, Mount DB, Gamba G. Functional and molecular characterization of the K-Cl cotransporter of Xenopus laevis oocytes. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C670-80.
    View in: PubMed
  54. Steinlein OK, Neubauer BA, Sander T, Song L, Stoodt J, Mount DB. Mutation analysis of the potassium chloride cotransporter KCC3 (SLC12A6) in rolandic and idiopathic generalized epilepsy. Epilepsy Res. 2001 May; 44(2-3):191-5.
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  55. Liu Z, Hall JD, Mount DW. Arabidopsis UVH3 gene is a homolog of the Saccharomyces cerevisiae RAD2 and human XPG DNA repair genes. Plant J. 2001 May; 26(3):329-38.
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  56. Pearson MM, Lu J, Mount DB, Delpire E. Localization of the K(+)-Cl(-) cotransporter, KCC3, in the central and peripheral nervous systems: expression in the choroid plexus, large neurons and white matter tracts. Neuroscience. 2001; 103(2):481-91.
    View in: PubMed
  57. Mercado A, Song L, Vazquez N, Mount DB, Gamba G. Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4. J Biol Chem. 2000 Sep 29; 275(39):30326-34.
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  58. D'Agata EM, Mount DB, Thayer V, Schaffner W. Hospital-acquired infections among chronic hemodialysis patients. Am J Kidney Dis. 2000 Jun; 35(6):1083-8.
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  59. Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G. Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. J Biol Chem. 1999 Jun 4; 274(23):16355-62.
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  60. Liu H, Mount DB, Nasjletti A, Wang W. Carbon monoxide stimulates the apical 70-pS K+ channel of the rat thick ascending limb. J Clin Invest. 1999 Apr; 103(7):963-70.
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  61. Plata C, Mount DB, Rubio V, Hebert SC, Gamba G. Isoforms of the Na-K-2Cl cotransporter in murine TAL II. Functional characterization and activation by cAMP. Am J Physiol. 1999 Mar; 276(3 Pt 2):F359-66.
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  62. Mount DB, Baekgaard A, Hall AE, Plata C, Xu J, Beier DR, Gamba G, Hebert SC. Isoforms of the Na-K-2Cl cotransporter in murine TAL I. Molecular characterization and intrarenal localization. Am J Physiol. 1999 Mar; 276(3 Pt 2):F347-58.
    View in: PubMed
  63. Attmane-Elakeb A, Mount DB, Sibella V, Vernimmen C, Hebert SC, Bichara M. Stimulation by in vivo and in vitro metabolic acidosis of expression of rBSC-1, the Na+-K+(NH4+)-2Cl- cotransporter of the rat medullary thick ascending limb. J Biol Chem. 1998 Dec 11; 273(50):33681-91.
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  64. Luyckx VA, Goda FO, Mount DB, Nishio T, Hall A, Hebert SC, Hammond TG, Yu AS. Intrarenal and subcellular localization of rat CLC5. Am J Physiol. 1998 Nov; 275(5 Pt 2):F761-9.
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  65. Mount DB, Delpire E, Gamba G, Hall AE, Poch E, Hoover RS, Hebert SC. The electroneutral cation-chloride cotransporters. J Exp Biol. 1998 Jul; 201(Pt 14):2091-102.
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  66. Mount DB, Hoover RS, Hebert SC. The molecular physiology of electroneutral cation-chloride cotransport. J Membr Biol. 1997 Aug 1; 158(3):177-86.
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  67. Kaplan MR, Mount DB, Delpire E. Molecular mechanisms of NaCl cotransport. Annu Rev Physiol. 1996; 58:649-68.
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  68. Jenkins ME, Harlow GR, Liu Z, Shotwell MA, Ma J, Mount DW. Radiation-sensitive mutants of Arabidopsis thaliana. Genetics. 1995 Jun; 140(2):725-32.
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  69. Duncan-Hewitt WC, Mount DL, Yu A. Hardness anisotropy of acetaminophen crystals. Pharm Res. 1994 May; 11(5):616-23.
    View in: PubMed
  70. Park IR, Mount DB, Himms-Hagen J. Role of T3 in thermogenic and trophic responses of brown adipose tissue to cold. Am J Physiol. 1989 Jul; 257(1 Pt 1):E81-7.
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  71. Gibbs JS, Chiou HC, Hall JD, Mount DW, Retondo MJ, Weller SK, Coen DM. Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain. Proc Natl Acad Sci U S A. 1985 Dec; 82(23):7969-73.
    View in: PubMed
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