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Michael N. Starnbach, Ph.D.

TitleProfessor of Microbiology and Immunobiology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Medical School
MBIB, Room 852 A
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-1873
Fax617/738-7664

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN. Chlamydia trachomatis-Induced Alterations in the Host Cell Proteome Are Required for Intracellular Growth. Cell Host Microbe. 2014 Jan 15; 15(1):113-24.
    View in: PubMed
  2. Fankhauser SC, Starnbach MN. PD-L1 Limits the Mucosal CD8+ T Cell Response to Chlamydia trachomatis. J Immunol. 2014 Feb 1; 192(3):1079-90.
    View in: PubMed
  3. Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM. A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. Nat Cell Biol. 2013 Dec; 15(12):1473-85.
    View in: PubMed
  4. McCluskey AJ, Olive AJ, Starnbach MN, Collier RJ. Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen. Mol Oncol. 2013 Jun; 7(3):440-51.
    View in: PubMed
  5. Jehl SP, Nogueira CV, Zhang X, Starnbach MN. IFN? inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I. PLoS Pathog. 2012; 8(8):e1002809.
    View in: PubMed
  6. Gondek DC, Olive AJ, Stary G, Starnbach MN. CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract. J Immunol. 2012 Sep 1; 189(5):2441-9.
    View in: PubMed
  7. Rosmarin DM, Carette JE, Olive AJ, Starnbach MN, Brummelkamp TR, Ploegh HL. Attachment of Chlamydia trachomatis L2 to host cells requires sulfation. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):10059-64.
    View in: PubMed
  8. Lamousé-Smith ES, Tzeng A, Starnbach MN. The intestinal flora is required to support antibody responses to systemic immunization in infant and germ free mice. PLoS One. 2011; 6(11):e27662.
    View in: PubMed
  9. Coers J, Gondek DC, Olive AJ, Rohlfing A, Taylor GA, Starnbach MN. Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. PLoS Pathog. 2011 Jun; 7(6):e1001346.
    View in: PubMed
  10. Jehl SP, Doling AM, Giddings KS, Phalipon A, Sansonetti PJ, Goldberg MB, Starnbach MN. Antigen-specific CD8(+) T cells fail to respond to Shigella flexneri. Infect Immun. 2011 May; 79(5):2021-30.
    View in: PubMed
  11. Olive AJ, Gondek DC, Starnbach MN. CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa. Mucosal Immunol. 2011 Mar; 4(2):208-16.
    View in: PubMed
  12. Bergman MA, Loomis WP, Mecsas J, Starnbach MN, Isberg RR. CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. PLoS Pathog. 2009 Sep; 5(9):e1000573.
    View in: PubMed
  13. Gondek DC, Roan NR, Starnbach MN. T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis. J Immunol. 2009 Jul 15; 183(2):1313-9.
    View in: PubMed
  14. Coers J, Starnbach MN, Howard JC. Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses. PLoS Pathog. 2009 May; 5(5):e1000333.
    View in: PubMed
  15. Henry SC, Daniell XG, Burroughs AR, Indaram M, Howell DN, Coers J, Starnbach MN, Hunn JP, Howard JC, Feng CG, Sher A, Taylor GA. Balance of Irgm protein activities determines IFN-gamma-induced host defense. J Leukoc Biol. 2009 May; 85(5):877-85.
    View in: PubMed
  16. Nunes JK, Starnbach MN, Wirth DF. Secreted antibody is required for immunity to Plasmodium berghei. Infect Immun. 2009 Jan; 77(1):414-8.
    View in: PubMed
  17. Coers J, Bernstein-Hanley I, Grotsky D, Parvanova I, Howard JC, Taylor GA, Dietrich WF, Starnbach MN. Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. J Immunol. 2008 May 1; 180(9):6237-45.
    View in: PubMed
  18. van der Velden AW, Dougherty JT, Starnbach MN. Down-modulation of TCR expression by Salmonella enterica serovar Typhimurium. J Immunol. 2008 Apr 15; 180(8):5569-74.
    View in: PubMed
  19. Shaw CA, Starnbach MN. Both CD4+ and CD8+ T cells respond to antigens fused to anthrax lethal toxin. Infect Immun. 2008 Jun; 76(6):2603-11.
    View in: PubMed
  20. Starnbach MN, Roan NR. Conquering sexually transmitted diseases. Nat Rev Immunol. 2008 Apr; 8(4):313-7.
    View in: PubMed
  21. Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL. Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3831-6.
    View in: PubMed
  22. Shaw CA, Starnbach MN. Antigen delivered by anthrax lethal toxin induces the development of memory CD8+ T cells that can be rapidly boosted and display effector functions. Infect Immun. 2008 Mar; 76(3):1214-22.
    View in: PubMed
  23. Roan NR, Starnbach MN. Immune-mediated control of Chlamydia infection. Cell Microbiol. 2008 Jan; 10(1):9-19.
    View in: PubMed
  24. Kramer RW, Slagowski NL, Eze NA, Giddings KS, Morrison MF, Siggers KA, Starnbach MN, Lesser CF. Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation. PLoS Pathog. 2007 Feb; 3(2):e21.
    View in: PubMed
  25. Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, Ploegh HL. Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. ACS Chem Biol. 2006 Dec 20; 1(11):713-23.
    View in: PubMed
  26. Roan NR, Starnbach MN. Antigen-specific CD8+ T cells respond to Chlamydia trachomatis in the genital mucosa. J Immunol. 2006 Dec 1; 177(11):7974-9.
    View in: PubMed
  27. D'Orazio SE, Troese MJ, Starnbach MN. Cytosolic localization of Listeria monocytogenes triggers an early IFN-gamma response by CD8+ T cells that correlates with innate resistance to infection. J Immunol. 2006 Nov 15; 177(10):7146-54.
    View in: PubMed
  28. Balsara ZR, Misaghi S, Lafave JN, Starnbach MN. Chlamydia trachomatis infection induces cleavage of the mitotic cyclin B1. Infect Immun. 2006 Oct; 74(10):5602-8.
    View in: PubMed
  29. Loomis WP, Starnbach MN. Chlamydia trachomatis infection alters the development of memory CD8+ T cells. J Immunol. 2006 Sep 15; 177(6):4021-7.
    View in: PubMed
  30. Bernstein-Hanley I, Coers J, Balsara ZR, Taylor GA, Starnbach MN, Dietrich WF. The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):14092-7.
    View in: PubMed
  31. Roan NR, Gierahn TM, Higgins DE, Starnbach MN. Monitoring the T cell response to genital tract infection. Proc Natl Acad Sci U S A. 2006 Aug 8; 103(32):12069-74.
    View in: PubMed
  32. Misaghi S, Balsara ZR, Catic A, Spooner E, Ploegh HL, Starnbach MN. Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. Mol Microbiol. 2006 Jul; 61(1):142-50.
    View in: PubMed
  33. Balsara ZR, Roan NR, Steele LN, Starnbach MN. Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen. J Infect Dis. 2006 May 15; 193(10):1459-63.
    View in: PubMed
  34. Bernstein-Hanley I, Balsara ZR, Ulmer W, Coers J, Starnbach MN, Dietrich WF. Genetic analysis of susceptibility to Chlamydia trachomatis in mouse. Genes Immun. 2006 Mar; 7(2):122-9.
    View in: PubMed
  35. D'Orazio SE, Shaw CA, Starnbach MN. H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes. J Exp Med. 2006 Feb 20; 203(2):383-91.
    View in: PubMed
  36. Shaw CA, Starnbach MN. Stimulation of CD8+ T cells following diphtheria toxin-mediated antigen delivery into dendritic cells. Infect Immun. 2006 Feb; 74(2):1001-8.
    View in: PubMed
  37. van der Velden AW, Copass MK, Starnbach MN. Salmonella inhibit T cell proliferation by a direct, contact-dependent immunosuppressive effect. Proc Natl Acad Sci U S A. 2005 Dec 6; 102(49):17769-74.
    View in: PubMed
  38. Cavanagh LL, Bonasio R, Mazo IB, Halin C, Cheng G, van der Velden AW, Cariappa A, Chase C, Russell P, Starnbach MN, Koni PA, Pillai S, Weninger W, von Andrian UH. Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nat Immunol. 2005 Oct; 6(10):1029-37.
    View in: PubMed
  39. Ho TD, Starnbach MN. The Salmonella enterica serovar typhimurium-encoded type III secretion systems can translocate Chlamydia trachomatis proteins into the cytosol of host cells. Infect Immun. 2005 Feb; 73(2):905-11.
    View in: PubMed
  40. Steele LN, Balsara ZR, Starnbach MN. Hematopoietic cells are required to initiate a Chlamydia trachomatis-specific CD8+ T cell response. J Immunol. 2004 Nov 15; 173(10):6327-37.
    View in: PubMed
  41. van der Velden AW, Velasquez M, Starnbach MN. Salmonella rapidly kill dendritic cells via a caspase-1-dependent mechanism. J Immunol. 2003 Dec 15; 171(12):6742-9.
    View in: PubMed
  42. D'Orazio SE, Velasquez M, Roan NR, Naveiras-Torres O, Starnbach MN. The Listeria monocytogenes lemA gene product is not required for intracellular infection or to activate fMIGWII-specific T cells. Infect Immun. 2003 Dec; 71(12):6721-7.
    View in: PubMed
  43. Starnbach MN, Loomis WP, Ovendale P, Regan D, Hess B, Alderson MR, Fling SP. An inclusion membrane protein from Chlamydia trachomatis enters the MHC class I pathway and stimulates a CD8+ T cell response. J Immunol. 2003 Nov 1; 171(9):4742-9.
    View in: PubMed
  44. Starnbach MN, Collier RJ. Anthrax delivers a lethal blow to host immunity. Nat Med. 2003 Aug; 9(8):996-7.
    View in: PubMed
  45. D'Orazio SE, Halme DG, Ploegh HL, Starnbach MN. Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection. J Immunol. 2003 Jul 1; 171(1):291-8.
    View in: PubMed
  46. Loomis WP, Starnbach MN. T cell responses to Chlamydia trachomatis. Curr Opin Microbiol. 2002 Feb; 5(1):87-91.
    View in: PubMed
  47. Boyartchuk VL, Broman KW, Mosher RE, D'Orazio SE, Starnbach MN, Dietrich WF. Multigenic control of Listeria monocytogenes susceptibility in mice. Nat Genet. 2001 Mar; 27(3):259-60.
    View in: PubMed
  48. Fling SP, Sutherland RA, Steele LN, Hess B, D'Orazio SE, Maisonneuve J, Lampe MF, Probst P, Starnbach MN. CD8+ T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1160-5.
    View in: PubMed
  49. Lu Y, Friedman R, Kushner N, Doling A, Thomas L, Touzjian N, Starnbach M, Lieberman J. Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity. Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14):8027-32.
    View in: PubMed
  50. Zarozinski CC, Collier RJ, Starnbach MN. Use of anthrax toxin fusions to stimulate immune responses. Methods Enzymol. 2000; 326:542-51.
    View in: PubMed
  51. Doling AM, Ballard JD, Shen H, Krishna KM, Ahmed R, Collier RJ, Starnbach MN. Cytotoxic T-lymphocyte epitopes fused to anthrax toxin induce protective antiviral immunity. Infect Immun. 1999 Jul; 67(7):3290-6.
    View in: PubMed
  52. Lampe MF, Wilson CB, Bevan MJ, Starnbach MN. Gamma interferon production by cytotoxic T lymphocytes is required for resolution of Chlamydia trachomatis infection. Infect Immun. 1998 Nov; 66(11):5457-61.
    View in: PubMed
  53. Ballard JD, Collier RJ, Starnbach MN. Anthrax toxin as a molecular tool for stimulation of cytotoxic T lymphocytes: disulfide-linked epitopes, multiple injections, and role of CD4(+) cells. Infect Immun. 1998 Oct; 66(10):4696-9.
    View in: PubMed
  54. Ballard JD, Doling AM, Beauregard K, Collier RJ, Starnbach MN. Anthrax toxin-mediated delivery in vivo and in vitro of a cytotoxic T-lymphocyte epitope from ovalbumin. Infect Immun. 1998 Feb; 66(2):615-9.
    View in: PubMed
  55. Ballard JD, Collier RJ, Starnbach MN. Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12531-4.
    View in: PubMed
  56. Starnbach MN, Bevan MJ, Lampe MF. Murine cytotoxic T lymphocytes induced following Chlamydia trachomatis intraperitoneal or genital tract infection respond to cells infected with multiple serovars. Infect Immun. 1995 Sep; 63(9):3527-30.
    View in: PubMed
  57. Starnbach MN, Bevan MJ, Lampe MF. Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis. J Immunol. 1994 Dec 1; 153(11):5183-9.
    View in: PubMed
  58. Starnbach MN, Bevan MJ. Cells infected with Yersinia present an epitope to class I MHC-restricted CTL. J Immunol. 1994 Aug 15; 153(4):1603-12.
    View in: PubMed
  59. Francis CL, Starnbach MN, Falkow S. Morphological and cytoskeletal changes in epithelial cells occur immediately upon interaction with Salmonella typhimurium grown under low-oxygen conditions. Mol Microbiol. 1992 Nov; 6(21):3077-87.
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  60. Starnbach MN, Lory S. The fliA (rpoF) gene of Pseudomonas aeruginosa encodes an alternative sigma factor required for flagellin synthesis. Mol Microbiol. 1992 Feb; 6(4):459-69.
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  61. Starnbach MN. Bacterial Motility and Association with Mammalian Cells. 1992.
  62. Starnbach MN, Falkow S, Tompkins LS. Species-specific detection of Legionella pneumophila in water by DNA amplification and hybridization. J Clin Microbiol. 1989 Jun; 27(6):1257-61.
    View in: PubMed
  63. Finlay BB, Starnbach MN, Francis CL, Stocker BA, Chatfield S, Dougan G, Falkow S. Identification and characterization of TnphoA mutants of Salmonella that are unable to pass through a polarized MDCK epithelial cell monolayer. Mol Microbiol. 1988 Nov; 2(6):757-66.
    View in: PubMed
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