 Peter Libby, M.D.
| Title | Mallinckrodt Professor of Medicine |
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| Institution | Brigham and Women's Hospital |
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| Department | Medicine |
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| Address | Brigham and Women's Hospital
Cardiovascular Medicine
75 Francis St
Boston MA 02115
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| Phone | 617/732-8086 |
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| Fax | 617/264-5111 |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Zamani P, Schwartz GG, Olsson AG, Rifai N, Bao W, Libby P, Ganz P, Kinlay S. Inflammatory Biomarkers, Death, and Recurrent Nonfatal Coronary Events After an Acute Coronary Syndrome in the MIRACL Study. J Am Heart Assoc. 2013; 2(1):e003103.
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Majmudar MD, Yoo J, Keliher EJ, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques. Circ Res. 2013 Mar 1; 112(5):755-61.
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Okamoto Y, Ishii S, Croce K, Katsumata H, Fukushima M, Kihara S, Libby P, Minami S. Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques. Atherosclerosis. 2013 Feb; 226(2):373-7.
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Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, Latini R, Libby P, Lombardi F, O'Gara PT, Page RL, Tavazzi L, Tognoni G. Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. JAMA. 2012 Nov 21; 308(19):2001-11.
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Ridker PM, Howard CP, Walter V, Everett B, Libby P, Hensen J, Thuren T. Effects of interleukin-1ß inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial. Circulation. 2012 Dec 4; 126(23):2739-48.
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Cheng X, Wang J, Xia N, Yan XX, Tang TT, Chen H, Zhang HJ, Liu J, Kong W, Sjöberg S, Folco E, Libby P, Liao YH, Shi GP. A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 2012 Oct; 4(10):1112-25.
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Cheng X, Folco EJ, Shimizu K, Libby P. Adiponectin Induces Pro-inflammatory Programs in Human Macrophages and CD4+ T Cells. J Biol Chem. 2012 Oct 26; 287(44):36896-904.
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Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2045-51.
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Ridker PM, Pradhan A, MacFadyen JG, Libby P, Glynn RJ. Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial. Lancet. 2012 Aug 11; 380(9841):565-71.
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Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M. Myocardial infarction accelerates atherosclerosis. Nature. 2012 Jul 19; 487(7407):325-9.
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Quillard T, Libby P. Molecular imaging of atherosclerosis for improving diagnostic and therapeutic development. Circ Res. 2012 Jul 6; 111(2):231-44.
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Libby P. Peter Libby, MD: a conversation with the editor. Am J Cardiol. 2012 Sep 1; 110(5):741-60.
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Gallino A, Stuber M, Crea F, Falk E, Corti R, Lekakis J, Schwitter J, Camici P, Gaemperli O, Di Valentino M, Prior J, Garcia-Garcia HM, Vlachopoulos C, Cosentino F, Windecker S, Pedrazzini G, Conti R, Mach F, De Caterina R, Libby P. "In vivo" imaging of atherosclerosis. Atherosclerosis. 2012 Sep; 224(1):25-36.
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Libby P. Counterregulation rules in atherothrombosis. J Am Coll Cardiol. 2012 Apr 17; 59(16):1438-40.
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Camici PG, Rimoldi OE, Gaemperli O, Libby P. Non-invasive anatomic and functional imaging of vascular inflammation and unstable plaque. Eur Heart J. 2012 Jun; 33(11):1309-17.
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Moslehi J, Libby P. You Can't Run From Inflammation: Lower Extremity Ischemia, Hypoxia Signaling, and Macrophage Subtypes. Circ Res. 2012 Apr 13; 110(8):1045-6.
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Zamani P, Ganz P, Libby P, Sutradhar SC, Rifai N, Nicholls SJ, Nissen SE, Kinlay S. Relationship of antihypertensive treatment to plasma markers of vascular inflammation and remodeling in the Comparison of Amlodipine versus Enalapril to Limit Occurrences of Thrombosis study. Am Heart J. 2012 Apr; 163(4):735-40.
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Nahrendorf M, McCarthy JR, Libby P. Over a hump for imaging atherosclerosis: nanobodies visualize vascular cell adhesion molecule-1 in inflamed plaque. Circ Res. 2012 Mar 30; 110(7):902-3.
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Swirski FK, Nahrendorf M, Libby P. The ins and outs of inflammatory cells in atheromata. Cell Metab. 2012 Feb 8; 15(2):135-6.
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Tang EH, Libby P, Vanhoutte PM, Xu A. Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. J Cardiovasc Pharmacol. 2012 Feb; 59(2):116-23.
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Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012 Jan 16; 209(1):123-37.
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Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R, Swirski FK. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation. 2012 Jan 17; 125(2):364-74.
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Shimizu K, Libby P, Rocha VZ, Folco EJ, Shubiki R, Grabie N, Jang S, Lichtman AH, Shimizu A, Hogg N, Simon DI, Mitchell RN, Croce K. Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection. Circulation. 2011 Dec 20; 124(25):2920-32.
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Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM, Libby P, Raichlen JS, Uno K, Borgman M, Wolski K, Nissen SE. Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med. 2011 Dec 1; 365(22):2078-87.
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Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, Sukhova GK, Aikawa E, Aikawa M, Libby P. Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2464-72.
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Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP. Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2500-8.
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Libby P, Folco E. Tension in the plaque: hypoxia modulates metabolism in atheroma. Circ Res. 2011 Oct 28; 109(10):1100-2.
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Wolf D, Hohmann JD, Wiedemann A, Bledzka K, Blankenbach H, Marchini T, Gutte K, Zeschky K, Bassler N, Hoppe N, Rodriguez AO, Herr N, Hilgendorf I, Stachon P, Willecke F, Duerschmied D, von zur Muhlen C, Soloviev DA, Zhang L, Bode C, Plow EF, Libby P, Peter K, Zirlik A. Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice. Circ Res. 2011 Nov 11; 109(11):1269-79.
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Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol. 2011 Nov; 29(11):1005-10.
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Medzhitov R, Shevach EM, Trinchieri G, Mellor AL, Munn DH, Gordon S, Libby P, Hansson GK, Shortman K, Dong C, Gabrilovich D, Gabryšová L, Howes A, O'Garra A. Highlights of 10 years of immunology in Nature Reviews Immunology. Nat Rev Immunol. 2011 Oct; 11(10):693-702.
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Ridker PM, Thuren T, Zalewski A, Libby P. Interleukin-1ß inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J. 2011 Oct; 162(4):597-605.
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Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011 Sep; 121(9):3564-77.
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Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xia M, Xiong N, Gelb BD, Shi GP. Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):15-23.
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Folco EJ, Sheikine Y, Rocha VZ, Christen T, Shvartz E, Sukhova GK, Di Carli MF, Libby P. Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomography. J Am Coll Cardiol. 2011 Aug 2; 58(6):603-14.
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Umeda H, Aikawa M, Libby P. Liberation of desmosine and isodesmosine as amino acids from insoluble elastin by elastolytic proteases. Biochem Biophys Res Commun. 2011 Jul 29; 411(2):281-6.
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Jaffer FA, Calfon MA, Rosenthal A, Mallas G, Razansky RN, Mauskapf A, Weissleder R, Libby P, Ntziachristos V. Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury. J Am Coll Cardiol. 2011 Jun 21; 57(25):2516-26.
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Mozaffarian D, Marchioli R, Gardner T, Ferrazzi P, O'Gara P, Latini R, Libby P, Lombardi F, Macchia A, Page R, Santini M, Tavazzi L, Tognoni G. The ?-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation trial--rationale and design. Am Heart J. 2011 Jul; 162(1):56-63.e3.
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Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA. Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques. Sci Transl Med. 2011 May 25; 3(84):84ra45.
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Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011 May 19; 473(7347):317-25.
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Buxton DB, Antman M, Danthi N, Dilsizian V, Fayad ZA, Garcia MJ, Jaff MR, Klimas M, Libby P, Nahrendorf M, Sinusas AJ, Wickline SA, Wu JC, Bonow RO, Weissleder R. Report of the National Heart, Lung, and Blood Institute working group on the translation of cardiovascular molecular imaging. Circulation. 2011 May 17; 123(19):2157-63.
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Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP. Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation. Circ Res. 2011 May 27; 108(11):1316-27.
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Nicholls SJ, Borgman M, Nissen SE, Raichlen JS, Ballantyne C, Barter P, Chapman MJ, Erbel R, Libby P. Impact of statins on progression of atherosclerosis: rationale and design of SATURN (Study of Coronary Atheroma by InTravascular Ultrasound: effect of Rosuvastatin versus AtorvastatiN). Curr Med Res Opin. 2011 Jun; 27(6):1119-29.
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Chatzizisis YS, Baker AB, Sukhova GK, Koskinas KC, Papafaklis MI, Beigel R, Jonas M, Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Feldman CL, Edelman ER, Stone PH. Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs. Circulation. 2011 Feb 15; 123(6):621-30.
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Quillard T, Croce K, Jaffer FA, Weissleder R, Libby P. Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo. Thromb Haemost. 2011 May; 105(5):828-36.
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Tang EH, Shvartz E, Shimizu K, Rocha VZ, Zheng C, Fukuda D, Shi GP, Sukhova G, Libby P. Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):261-9.
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Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M. High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. Circulation. 2010 Oct 26; 122(17):1707-15.
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Libby P, Croce K. Visualizing the vascular glue "shearing" the barriers to atherosclerotic plaque imaging. JACC Cardiovasc Imaging. 2010 Sep; 3(9):956-8.
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Tang EH, Shimizu K, Christen T, Rocha VZ, Shvartz E, Tesmenitsky Y, Sukhova G, Shi GP, Libby P. Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions. Cardiovasc Res. 2011 Jan 1; 89(1):234-43.
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Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum JL, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 2010 Aug 24; 122(8):808-20.
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Christen T, Sheikine Y, Rocha VZ, Hurwitz S, Goldfine AB, Di Carli M, Libby P. Increased glucose uptake in visceral versus subcutaneous adipose tissue revealed by PET imaging. JACC Cardiovasc Imaging. 2010 Aug; 3(8):843-51.
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Ridker PM, Genest J, Boekholdt SM, Libby P, Gotto AM, Nordestgaard BG, Mora S, MacFadyen JG, Glynn RJ, Kastelein JJ. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet. 2010 Jul 31; 376(9738):333-9.
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Ridker PM, MacFadyen J, Libby P, Glynn RJ. Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER). Am J Cardiol. 2010 Jul 15; 106(2):204-9.
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Schulte S, Sun J, Libby P, Macfarlane L, Sun C, Lopez-Ilasaca M, Shi GP, Sukhova GK. Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice. Am J Pathol. 2010 Jul; 177(1):456-63.
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Croce K, Libby P. Stirring the soup of innate immunity in the acute coronary syndromes. Eur Heart J. 2010 Jun; 31(12):1430-2.
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Missiou A, Köstlin N, Varo N, Rudolf P, Aichele P, Ernst S, Münkel C, Walter C, Stachon P, Sommer B, Pfeifer D, Zirlik K, MacFarlane L, Wolf D, Tsitsikov E, Bode C, Libby P, Zirlik A. Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall. Circulation. 2010 May 11; 121(18):2033-44.
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Libby P, DiCarli M, Weissleder R. The vascular biology of atherosclerosis and imaging targets. J Nucl Med. 2010 May 1; 51 Suppl 1:33S-37S.
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Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010 Apr 13; 55(15):1629-38.
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Libby P. How our growing understanding of inflammation has reshaped the way we think of disease and drug development. Clin Pharmacol Ther. 2010 Apr; 87(4):389-91.
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Eagle KA, Ginsburg GS, Musunuru K, Aird WC, Balaban RS, Bennett SK, Blumenthal RS, Coughlin SR, Davidson KW, Frohlich ED, Greenland P, Jarvik GP, Libby P, Pepine CJ, Ruskin JN, Stillman AE, Van Eyk JE, Tolunay HE, McDonald CL, Smith SC. Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation. 2010 Mar 30; 121(12):1447-54.
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Libby P, Crea F. Clinical implications of inflammation for cardiovascular primary prevention. Eur Heart J. 2010 Apr; 31(7):777-83.
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Missiou A, Wolf D, Platzer I, Ernst S, Walter C, Rudolf P, Zirlik K, Köstlin N, Willecke FK, Münkel C, Schönbeck U, Libby P, Bode C, Varo N, Zirlik A. CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease. Thromb Haemost. 2010 Apr; 103(4):788-96.
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Chan JM, Zhang L, Tong R, Ghosh D, Gao W, Liao G, Yuet KP, Gray D, Rhee JW, Cheng J, Golomb G, Libby P, Langer R, Farokhzad OC. Spatiotemporal controlled delivery of nanoparticles to injured vasculature. Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5):2213-8.
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Libby P, Okamoto Y, Rocha VZ, Folco E. Inflammation in atherosclerosis: transition from theory to practice. Circ J. 2010 Feb; 74(2):213-20.
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Libby P, Nahrendorf M, Weissleder R. Molecular imaging of atherosclerosis: a progress report. Tex Heart Inst J. 2010; 37(3):324-7.
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Libby P, Ridker PM, Hansson GK. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009 Dec 1; 54(23):2129-38.
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Shimizu K, Minami M, Shubiki R, Lopez-Ilasaca M, MacFarlane L, Asami Y, Li Y, Mitchell RN, Libby P. CC chemokine receptor-1 activates intimal smooth muscle-like cells in graft arterial disease. Circulation. 2009 Nov 3; 120(18):1800-13.
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Okamoto Y, Christen T, Shimizu K, Asano K, Kihara S, Mitchell RN, Libby P. Adiponectin inhibits allograft rejection in murine cardiac transplantation. Transplantation. 2009 Oct 15; 88(7):879-83.
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Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R. 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis. JACC Cardiovasc Imaging. 2009 Oct; 2(10):1213-22.
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Ridker PM, MacFadyen JG, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ. Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin (JUPITER). Circ Cardiovasc Qual Outcomes. 2009 Nov; 2(6):616-23.
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Heinonen T, Waters DD, Libby P, Tardif JC. A winter's tale: report from the First Annual Canadian Biomarkers and Surrogate Endpoints Symposium. Can J Cardiol. 2009 Sep; 25(9):527-32.
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Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation. 2009 Sep 15; 120(11):973-82.
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Swanson D, Graham M, Heinonen TM, Libby P, Mills GQ. Current good manufacturing practices for PET drug products in the United States. J Nucl Med. 2009 Aug; 50(8):26N-8N.
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Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009 Jul 31; 325(5940):612-6.
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Andersson J, Libby P, Hansson GK. Adaptive immunity and atherosclerosis. Clin Immunol. 2010 Jan; 134(1):33-46.
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Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5.
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Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P, Simon DI. Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation. 2009 Aug 4; 120(5):427-36.
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Folco EJ, Rocha VZ, López-Ilasaca M, Libby P. Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10. J Biol Chem. 2009 Sep 18; 284(38):25569-75.
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Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem. 2009 Sep 11; 284(37):24914-24.
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Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, Offenbacher S, Ridker PM, Van Dyke TE, Roberts WC. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol. 2009 Jul; 80(7):1021-32.
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Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, Offenbacher S, Ridker PM, Van Dyke TE, Roberts WC. The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: periodontitis and atherosclerotic cardiovascular disease. Am J Cardiol. 2009 Jul 1; 104(1):59-68.
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Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum JL, Tsimikas S. Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. J Am Coll Cardiol. 2009 Jun 9; 53(23):2186-96.
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Wildgruber M, Lee H, Chudnovskiy A, Yoon TJ, Etzrodt M, Pittet MJ, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski FK. Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PLoS One. 2009; 4(5):e5663.
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Packard RR, Lichtman AH, Libby P. Innate and adaptive immunity in atherosclerosis. Semin Immunopathol. 2009 Jun; 31(1):5-22.
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Wiviott SD, Mohanavelu S, Raichlen JS, Cain VA, Nissen SE, Libby P. Safety and efficacy of achieving very low low-density lipoprotein cholesterol levels with rosuvastatin 40 mg daily (from the ASTEROID Study). Am J Cardiol. 2009 Jul 1; 104(1):29-35.
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Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. 2009 Jun; 6(6):399-409.
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Jaffer FA, Libby P, Weissleder R. Optical and multimodality molecular imaging: insights into atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1017-24.
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Christen T, Nahrendorf M, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P. Molecular imaging of innate immune cell function in transplant rejection. Circulation. 2009 Apr 14; 119(14):1925-32.
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Glynn RJ, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Ridker PM. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med. 2009 Apr 30; 360(18):1851-61.
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Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, Macfadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009 Apr 4; 373(9670):1175-82.
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Kinlay S, Schwartz GG, Olsson AG, Rifai N, Bao W, Libby P, Ganz P. Endogenous tissue plasminogen activator and risk of recurrent cardiac events after an acute coronary syndrome in the MIRACL study. Atherosclerosis. 2009 Oct; 206(2):551-5.
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Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009 Apr 7; 119(13):1785-94.
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Becker MC, Wang TH, Wisniewski L, Wolski K, Libby P, Lüscher TF, Borer JS, Mascette AM, Husni ME, Solomon DH, Graham DY, Yeomans ND, Krum H, Ruschitzka F, Lincoff AM, Nissen SE. Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis. Am Heart J. 2009 Apr; 157(4):606-12.
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Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, Kihara S, Bloch KD, Libby P, Luster AD. Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol. 2009 Oct; 41(4):397-406.
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Deguchi JO, Huang H, Libby P, Aikawa E, Whittaker P, Sylvan J, Lee RT, Aikawa M. Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II. Lab Invest. 2009 Mar; 89(3):315-26.
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Ovchinnikova O, Robertson AK, Wågsäter D, Folco EJ, Hyry M, Myllyharju J, Eriksson P, Libby P, Hansson GK. T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe(-/-) mice. Am J Pathol. 2009 Feb; 174(2):693-700.
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Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65.
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Libby P. Molecular and cellular mechanisms of the thrombotic complications of atherosclerosis. J Lipid Res. 2009 Apr; 50 Suppl:S352-7.
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Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008 Nov 20; 359(21):2195-207.
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Kawakami A, Osaka M, Aikawa M, Uematsu S, Akira S, Libby P, Shimokado K, Sacks FM, Yoshida M. Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation. Circ Res. 2008 Dec 5; 103(12):1402-9.
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Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R. Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation. 2008 Oct 28; 118(18):1802-9.
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Packard RR, Maganto-García E, Gotsman I, Tabas I, Libby P, Lichtman AH. CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circ Res. 2008 Oct 24; 103(9):965-73.
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Libby P. Role of inflammation in atherosclerosis associated with rheumatoid arthritis. Am J Med. 2008 Oct; 121(10 Suppl 1):S21-31.
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Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol. 2008 Oct; 8(10):802-15.
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Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, Vernon AH, Libby P. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res. 2008 Aug 29; 103(5):467-76.
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Libby P, Nahrendorf M, Pittet MJ, Swirski FK. Diversity of denizens of the atherosclerotic plaque: not all monocytes are created equal. Circulation. 2008 Jun 24; 117(25):3168-70.
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Libby P. Should You Have an A.E.D. at Home?. 2008.
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Libby P. Folic Acid Fails Another Test [blog]. 2008.
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Schulte S, Sukhova GK, Libby P. Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. Am J Pathol. 2008 Jun; 172(6):1500-8.
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Libby P. The molecular mechanisms of the thrombotic complications of atherosclerosis. J Intern Med. 2008 May; 263(5):517-27.
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Libby P. Pain Relief Without the Heart Risks [blog]. 2008.
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Libby P. The Great Cholesterol Kerfuffle [blog]. 2008.
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Libby P. Backstage at a Real Medical Drama [blog]. 2008.
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Shimizu K, Libby P, Shubiki R, Sakuma M, Wang Y, Asano K, Mitchell RN, Simon DI. Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection. Circulation. 2008 Apr 15; 117(15):1997-2008.
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Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P. Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem. 2008 Apr 11; 283(15):9692-703.
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Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008 Mar 4; 117(9):1153-60.
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Schneider F, Sukhova GK, Aikawa M, Canner J, Gerdes N, Tang SM, Shi GP, Apte SS, Libby P. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation. 2008 Feb 19; 117(7):931-9.
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Rocha VZ, Libby P. The multiple facets of the fat tissue. Thyroid. 2008 Feb; 18(2):175-83.
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Kircher MF, Grimm J, Swirski FK, Libby P, Gerszten RE, Allport JR, Weissleder R. Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions. Circulation. 2008 Jan 22; 117(3):388-95.
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Croce K and Libby P. Inflammation and Arterial Disease. In: Moliterno, editor-in-chief. CathSAP 3, Cardiac Catheterization and Interventional Cardiology Self-Assessment Program. 2008.
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Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008 Jan; 54(1):24-38.
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Croce K and Libby P. Inflammation and Arterial Disease. In: Moliterno, editor-in-chief. CathSAP 3, Cardiac Catheterization and Interventional Cardiology Self-Assessment Program [CD-ROM]. 2008.
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Braunwald E, Libby P, Bonow R, Mann D. Foreword. In: Zipes D, ed. Clinical Arrhythmology and Electrophysiology. 2008.
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Libby P. . Atlas of Atherosclerosis. Fauci AS, Kasper DL, Braunwald E, Hauser SL, Longo DL, Jameson JL, Loscalzo J. Harrison’s Principles of Internal Medicine, 17th ed. 2008; e171.
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Libby P. Introduction of International Research Facilities: Brigham and Women's Hospital. Int Rev Thromb. 2008; 3:58-65.
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Libby P. Nanoparticle imaging of macrophages with molecular echocardiography [online lecture]. 2008.
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Libby P. Basic biology of the cardiovascular system. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson L, Loscalzo J, editors. Harrison’s principles of internal medicine, 17th ed. 2008; 1365-1374.
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Morrow DA, Wang Y, Croce K, Sakuma M, Sabatine MS, Gao H, Pradhan AD, Healy AM, Buros J, McCabe CH, Libby P, Cannon CP, Braunwald E, Simon DI. Myeloid-related protein-8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the PROVE IT-TIMI 22 trial. American Heart Journal. 2008; 155:49-55.
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Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder RCirculation. Nanoparticle positron-emission tomography-computed tomography imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008; 117:379-387.
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Packard R and Libby P. Atherosclerosis. Encyclopedia of Molecular Pharmacology. 2008; In press..
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Libby P. New vascular medicine/intervention section in Cardiology Today to keep audience informed of trends. Commentary. Cardiology Today. 2008; 11:15.
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Libby P. The pathogenesis, prevention, and treatment of atherosclerosis. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson L, Loscalzo J, editors. Harrison’s principles of internal medicine, 17th ed. 2008; 1501-1508.
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Isoda K, Folco E, Marwali MR, Ohsuzu F, Libby P. Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis. Atherosclerosis. 2008 Jun; 198(2):307-12.
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Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008 Jan 22; 117(3):379-87.
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Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev. 2007 Dec; 65(12 Pt 2):S140-6.
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Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007 Nov 26; 204(12):3037-47.
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Kardys I, Rifai N, Meilhac O, Michel JB, Martin-Ventura JL, Buring JE, Libby P, Ridker PM. Plasma concentration of heat shock protein 27 and risk of cardiovascular disease: a prospective, nested case-control study. Clin Chem. 2008 Jan; 54(1):139-46.
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Kinlay S, Schwartz GG, Olsson AG, Rifai N, Szarek M, Waters DD, Libby P, Ganz P. Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL study. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):142-7.
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Okamoto Y, Folco EJ, Minami M, Wara AK, Feinberg MW, Sukhova GK, Colvin RA, Kihara S, Funahashi T, Luster AD, Libby P. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res. 2008 Feb 1; 102(2):218-25.
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Morrow DA, Wang Y, Croce K, Sakuma M, Sabatine MS, Gao H, Pradhan AD, Healy AM, Buros J, McCabe CH, Libby P, Cannon CP, Braunwald E, Simon DI. Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial. Am Heart J. 2008 Jan; 155(1):49-55.
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Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest. 2007 Nov; 117(11):3359-68.
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Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P. A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages. Chem Biol. 2007 Nov; 14(11):1221-31.
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Ridker PM, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Khurmi NS, Koenig W, Libby P, Lorenzatti AJ, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ. Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein. Am J Cardiol. 2007 Dec 1; 100(11):1659-64.
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Libby P. 5th Annual Cardiovascular Biomarkers and Surrogate Endpoints Symposium. International Partnership for Critical Markers of Disease. 2007.
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Libby P [Content adviser.]. The Mysterious Human Heart. 2007.
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Libby P. Exercise and Pollution. 2007.
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Jaffer FA, Libby P, Weissleder R. Molecular imaging of cardiovascular disease. Circulation. 2007 Aug 28; 116(9):1052-61.
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Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug; 9(8):970-7.
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Zirlik A, Abdullah SM, Gerdes N, MacFarlane L, Schönbeck U, Khera A, McGuire DK, Vega GL, Grundy S, Libby P, de Lemos JA. Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study. Arterioscler Thromb Vasc Biol. 2007 Sep; 27(9):2043-9.
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Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007 Jun; 13(6):719-24.
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Libby P, Shi GP. Mast cells as mediators and modulators of atherogenesis. Circulation. 2007 May 15; 115(19):2471-3.
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Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):8077-82.
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Mitchell RN, Libby P. Vascular remodeling in transplant vasculopathy. Circ Res. 2007 Apr 13; 100(7):967-78.
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Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R. Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation. 2007 May 1; 115(17):2292-8.
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Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X, Peters C, Shi GP. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation. 2007 Apr 17; 115(15):2065-75.
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Miller DT, Ridker PM, Libby P, Kwiatkowski DJ. Atherosclerosis: the path from genomics to therapeutics. J Am Coll Cardiol. 2007 Apr 17; 49(15):1589-99.
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Larose E, Kinlay S, Selwyn AP, Yeghiazarians Y, Yucel EK, Kacher DF, Libby P, Ganz P. Improved characterization of atherosclerotic plaques by gadolinium contrast during intravascular magnetic resonance imaging of human arteries. Atherosclerosis. 2008 Feb; 196(2):919-25.
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Zirlik A, Maier C, Gerdes N, MacFarlane L, Soosairajah J, Bavendiek U, Ahrens I, Ernst S, Bassler N, Missiou A, Patko Z, Aikawa M, Schönbeck U, Bode C, Libby P, Peter K. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation. 2007 Mar 27; 115(12):1571-80.
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Schönbeck U, Ridker P, Libby P, inventors. Soluble CD40L(CD154) as a prognostic marker of atherosclerotic diseases. 2007.
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Zirlik A, Bavendiek U, Libby P, MacFarlane L, Gerdes N, Jagielska J, Ernst S, Aikawa M, Nakano H, Tsitsikov E, Schönbeck U. TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):1101-7.
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Libby P. Fat fuels the flame: triglyceride-rich lipoproteins and arterial inflammation. Circ Res. 2007 Feb 16; 100(3):299-301.
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Forrester JS, Libby P. The inflammation hypothesis and its potential relevance to statin therapy. Am J Cardiol. 2007 Mar 1; 99(5):732-8.
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Ridker PM, Danielson E, Fonseca FAH, Genest J, Gotto AM, Kastelein JJP, Koenig W, Libby P, Lorenzatti A, MacFadyen J, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, on behalf of the JUPITER Trial Study Group. Baseline characteristics of participants in the JUPITER Trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low LDL-C and elevated hsCRP. Am Heart J. 2007; 100:1659-1664.
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De Caterina R, Zampolli A, Lazzerini G, Libby P. Endothelial activation and the initiation of atherosclerosis. De Caterina R and Libby P, editors. Endothelial dysfunctions and vascular disease. 2007; 26-35.
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Farzaneh-Far A, Libby P. Are we victims of our own success in cardiovascular therapeutics? Curr Atheroscler Rep. 2007 Jan; 9(1):1-2.
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Libby P and Knappertz V, editors. Inflammation, Atherosclerosis, and Aspirin: New Insights. 2007.
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Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi G-P. Cathepsin I activity controls adipogenesis and glucose tolerance. Letter to the Editor. Nat Cell Bio. 2007; 9:970-981.
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Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007 Jan; 117(1):195-205.
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De Caterina R, Massaro M, Libby P. Endothelial functions and dysfunctions. De Caterina R and Libby P, editors. Endothelial dysfunctions and vascular disease. 2007; 3-25.
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Croce K, Libby P. Intertwining of thrombosis and inflammation in atherosclerosis [review]. Curr Opin Hematol Curr Opin Hematol. 2007; 14:55-61.
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Kol A, Libby P. Infections in vascular disease. De Caterina R and Libby P, editors. Endothelial dysfunctions and vascular disease. 2007; 165-175.
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Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC. Deletion of the phosphoinositide 3-kinase p110{gamma} gene attenuates murine atherosclerosis. Proc Natl Acad Sci USA. 2007; 104:8077-8082.
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Croce K, Libby P. Intertwining of thrombosis and inflammation in atherosclerosis. Curr Opin Hematol. 2007 Jan; 14(1):55-61.
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De Caterina R, Zampolli A, Del Turco S, Libby P. Mechanisms of plaque progression and complications. De Caterina R and Libby P, editors. Endothelial dysfunctions and vascular disease. 2007; 36-54.
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De Caterina R, Libby P, editors. Endothelial dysfunctions and vascular disease. 2007.
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Farzaneh-Far A, Libby P. Are we victims of our own success in cardiovascular therapeutics [editorial comment]. Curr Atheroscler Rep Curr Atheroscler Rep. 2007; 9:1-2.
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Aikawa M, Libby P. Treatment of endothelial dysfunction and atherosclerosis by cholesterol lowering. De Caterina R and Libby P, editors. Endothelial dysfunctions and vascular disease. 2007; 300-314.
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Ziouzenkova O, Marx N, Libby P, Plutzky J. PPARs in atherosclerosis. De Caterina R and Libby P, editors. Endothelial dysfunctions and vascular disease. 2007; 337-349.
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Libby P, Plutzky J. Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonists. Am J Cardiol. 2007 Feb 19; 99(4A):27B-40B.
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Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):175-81.
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Varo N, Nuzzo R, Natal C, Libby P, Schönbeck U. Influence of pre-analytical and analytical factors on soluble CD40L measurements. Clin Sci (Lond). 2006 Nov; 111(5):341-7.
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Libby P. Atherosclerosis: disease biology affecting the coronary vasculature. Am J Cardiol. 2006 Dec 18; 98(12A):3Q-9Q.
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Kawakami A, Aikawa M, Nitta N, Yoshida M, Libby P, Sacks FM. Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):219-25.
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Libby P, Sasiela W. Plaque stabilization: Can we turn theory into evidence? Am J Cardiol. 2006 Dec 4; 98(11A):26P-33P.
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Libby P. Perplexity of plaque proteinases. Arterioscler Thromb Vasc Biol. 2006 Oct; 26(10):2181-2.
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Isoda K, Folco EJ, Shimizu K, Libby P. AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL. Atherosclerosis. 2007 Jun; 192(2):298-304.
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Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 2006 Oct 3; 114(14):1504-11.
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Kawakami A, Aikawa M, Alcaide P, Luscinskas FW, Libby P, Sacks FM. Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells. Circulation. 2006 Aug 15; 114(7):681-7.
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Tardif JC, Heinonen T, Orloff D, Libby P. Vascular biomarkers and surrogates in cardiovascular disease. Circulation. 2006 Jun 27; 113(25):2936-42.
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Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10340-5.
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Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation. 2006 Jul 4; 114(1):55-62.
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Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 2006 Jul; 6(7):508-19.
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Farzaneh-Far A, Libby P, Singh D. Pravastatin, simvastatin, and atorvastatin appear equally effective for preventing cardiovascular events. Evid Based Cardiovasc Med. 2006 Jun; 10(2):135-7.
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Healy AM, Pickard MD, Pradhan AD, Wang Y, Chen Z, Croce K, Sakuma M, Shi C, Zago AC, Garasic J, Damokosh AI, Dowie TL, Poisson L, Lillie J, Libby P, Ridker PM, Simon DI. Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation. 2006 May 16; 113(19):2278-84.
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Montero I, Orbe J, Varo N, Beloqui O, Monreal JI, Rodríguez JA, Díez J, Libby P, Páramo JA. C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis. J Am Coll Cardiol. 2006 Apr 4; 47(7):1369-78.
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Jaffer FA, Libby P, Weissleder R. Molecular and cellular imaging of atherosclerosis: emerging applications. J Am Coll Cardiol. 2006 Apr 4; 47(7):1328-38.
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Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, Schoenhagen P, Crowe T, Cain V, Wolski K, Goormastic M, Tuzcu EM. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006 Apr 5; 295(13):1556-65.
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Okamoto Y, Kihara S, Funahashi T, Matsuzawa Y, Libby P. Adiponectin: a key adipocytokine in metabolic syndrome. Clin Sci (Lond). 2006 Mar; 110(3):267-78.
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Shimizu K, Mitchell RN, Libby P. Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):987-94.
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Kawakami A, Aikawa M, Libby P, Alcaide P, Luscinskas FW, Sacks FM. Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. Circulation. 2006 Feb 7; 113(5):691-700.
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Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr. 2006 Feb; 83(2):456S-460S.
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Duff GW, Libby P, Ordovas JM, Reilly PR. The future of living well to 100. Am J Clin Nutr. 2006 Feb; 83(2):488S-490S.
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Takayama K, Sukhova GK, Chin MT, Libby P. A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. Circ Res. 2006 Mar 3; 98(4):499-504.
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Libby P. Natural history of an atheroma [animated video]. 2006.
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Libby P. Heart Health in the Inflammation Age. Scientific American Presents Oral and Whole Body Health. 2006; 12-16.
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Koenig W, Libby P. Lipoprotein-associated phospholipase A2 (Lp-PLA2), atherosclerosis, and cardiovascular risk: An evolving story [slide kit]. 2006.
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Libby P. Atherosclerosis. Creager MA, Dzau VJ, Loscalzo J, editors. Vascular Medicine: A Companion to Braunwald’s Heart Disease. 2006; 101-118.
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Libby P. Inflammation in cardiovascular disease: the biological basis of inflammatory biomarkers. Morrow DA, editor. Cardiovascular Biomarkers: Pathophysiology and Disease Management. 2006; 207-221.
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Libby P. Atherosclerosis and inflammation. Ridker P, Rifai N, editors. C-reactive Protein and Cardiovascular Disease. 2006; 25-39.
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Libby P, Aikawa M, Jain MK. Vascular endothelium and atherosclerosis. Handb Exp Pharmacol. 2006; (176 Pt 2):285-306.
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Libby P, Ridker PM. Inflammation and atherothrombosis: from population biology and bench research to clinical practice. J Am Coll Cardiol. 2006; 48:A33-A46.
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Libby P. Pleiotropic effects of statins [animated video]. 2006.
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Libby P. Thrombin receptor antagonist MOA animation [animated 6’15” video]. 2006.
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Libby P. HDL, CETP, and cardiovascular risk [animated video]. 2006.
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Libby P, Simon DI, Ridker PM. Inflammation and atherothrombosis. Colman RW, Marder VJ, Clowes AW, George JN, Goldhaber SZ, editors. Hemostatis and thrombosis: basic principles and clinical practice, 5th edition. 2006; 795-812.
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Libby P. Introduction. Am J Cardiol. 2006; 998:S1 .
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Libby P. A dual approach to LDL cholesterol reduction: inhibiting cholesterol absorption and synthesis [DVD]. 2006.
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Libby P, Cooke J, van der Steen AFW. Inflammatory Aspects and Detection of Vulnerable Plaque [Webcast]. 2006.
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Libby P. LDL lowering by statins [animated video]. 2006.
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Libby P. Foreword. Baughman KL, Baumgartner, eds. Treatment of Advanced Heart Disease. 2006; v.
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Libby P. Lp-PLA2, arterial inflammation, and coronary artery disease [CD]. 2006.
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Libby P. Pathophysiology of vasculitis. Creager MA, Dzau VJ, Loscalzo J, editors. Vascular Medicine: A Companion to Braunwald’s Heart Disease. 2006; 119-124.
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Isoda K, Young JL, Zirlik A, MacFarlane LA, Tsuboi N, Gerdes N, Schönbeck U, Libby P. Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells. Arterioscler Thromb Vasc Biol. 2006 Mar; 26(3):611-7.
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Dollery CM, Libby P. Atherosclerosis and proteinase activation. Cardiovasc Res. 2006 Feb 15; 69(3):625-35.
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Sales VL, Sukhova GK, Lopez-Ilasaca MA, Libby P, Dzau VJ, Pratt RE. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation. 2005 Nov 22; 112(21):3328-36.
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Sugiyama S, Kugiyama K, Nakamura S, Kataoka K, Aikawa M, Shimizu K, Koide S, Mitchell RN, Ogawa H, Libby P. Characterization of smooth muscle-like cells in circulating human peripheral blood. Atherosclerosis. 2006 Aug; 187(2):351-62.
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Deguchi JO, Aikawa E, Libby P, Vachon JR, Inada M, Krane SM, Whittaker P, Aikawa M. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation. 2005 Oct 25; 112(17):2708-15.
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Libby P. The forgotten majority: unfinished business in cardiovascular risk reduction. J Am Coll Cardiol. 2005 Oct 4; 46(7):1225-8.
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Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P. Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging. Circulation. 2005 Oct 11; 112(15):2324-31.
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de Lemos JA, Zirlik A, Schönbeck U, Varo N, Murphy SA, Khera A, McGuire DK, Stanek G, Lo HS, Nuzzo R, Morrow DA, Peshock R, Libby P. Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study. Arterioscler Thromb Vasc Biol. 2005 Oct; 25(10):2192-6.
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Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation. 2005 Jul 26; 112(4):578-86.
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Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation. 2005 Jun 28; 111(25):3481-8.
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Libby P, Nathan DM, Abraham K, Brunzell JD, Fradkin JE, Haffner SM, Hsueh W, Rewers M, Roberts BT, Savage PJ, Skarlatos S, Wassef M, Rabadan-Diehl C. Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus. Circulation. 2005 Jun 28; 111(25):3489-93.
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Liu J, Sukhova GK, Yang JT, Sun J, Ma L, Ren A, Xu WH, Fu H, Dolganov GM, Hu C, Libby P, Shi GP. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis. 2006 Feb; 184(2):302-11.
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Libby P. Act local, act global: inflammation and the multiplicity of "vulnerable" coronary plaques. J Am Coll Cardiol. 2005 May 17; 45(10):1600-2.
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Shimizu K, Libby P, Mitchell RN. Local cytokine environments drive aneurysm formation in allografted aortas. Trends Cardiovasc Med. 2005 May; 15(4):142-8.
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Varo N, Libby P, Nuzzo R, Italiano J, Doria A, Schönbeck U. Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and advanced glycation end products. Diab Vasc Dis Res. 2005 May; 2(2):81-7.
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Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS. CADASIL mutations impair Notch3 glycosylation by Fringe. Hum Mol Genet. 2005 Jun 15; 14(12):1631-9.
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Bavendiek U, Zirlik A, LaClair S, MacFarlane L, Libby P, Schönbeck U. Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1244-9.
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Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005 Feb 18; 96(3):368-75.
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Sukhova GK, Libby P. The macrophage and the atherosclerotic process. Grundy SM, editor. Atlas of Atherosclerosis, 4th edition. 2005; 21-31.
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Libby P. Atherothrombosis and inflammation [CD]. In: State of the Art Symposium. Venous and Arterial Thrombosis: Recent Advances in Biology and Therapy. San Francisco, April 2005. 2005.
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Libby P. Closing the research-practice gap: a contemporary challenge for cardiovascular risk assessment and reduction [editorial]. ESLM Lipid Letter. 2005; 4 :1,12.
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Libby P. Prevention and treatment of atherosclerosis. Kasper DL, Braunwald E, Fauci S, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s Principles of Medicine, 16th ed. 2005; 1430-1433.
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Libby P. New frontiers in CV risk factor management [CD]. In: Gotto AM Jr., Libby P, co-chairs. Practice implications of endpoint trials in CV risk factor management. 2005.
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Ridker PM, Libby P. Risk factors for atherothrombotic disease. Zipes DP, Libby P, Bonow RO, Braunwald E, editors. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 7th edition. 2005; 939-958.
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Libby P. Scientific rationale for BP and lipid therapy [CD]. In: Gotto AM Jr., Libby P, co-chairs. Beyond the numbers: an integrated approach to CV risk. 2005.
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Libby P. Pathophysiology of plaque rupture/erosion. ACCSAP 6: Adult Clinical Cardiology Self-Assessment Program [Webcast]. 2005.
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Beckman JA, Creager MA, Libby P. Diabetes mellitus, the metabolic syndrome, and atherosclerotic disease. Zipes DP, Libby P, Bonow RO, Braunwald E, editors. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 7th edition. 2005; 1035-1046.
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Libby P. The vascular biology of atherosclerosis. Zipes DP, Libby P, Bonow RO, Braunwald E, editors. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 7th edition. 2005; 921-958.
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Libby P, Skerrett PJ. Searching for hidden heart risks. New technologies offer incredible images, but more tests are probably all you need. Newsweek. 2005; (CXLVI):73-74.
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Gotto AM, Jr., Libby P. Statin safety: weighing the evidence [editorial]. ESLM Lipid Letter. 2005; 5:1,4-6.
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Creager MA, Libby P. Peripheral arterial diseases. Zipes DP, Libby P, Bonow RO, Braunwald E, editors. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 7th edition. 2005; 1437-1461.
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Libby P. The biology of inflammation: a common pathway in cardiovascular disease, Part I. Textbook of Functional Medicine. 2005; 203-211.
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Pepine CJ, Bakris GL, Blumenthal RS, Libby P, Messerli FH, Redberg RF, Thadani U, Vaughn DE. Obesity, diabetes and the metabolic syndrome: the growing epidemic. Roundtable discussion. Part 1. Today Cardiol. 2005; 8:9-12.
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Pepine CJ, Bakris GL, Blumenthal RS, Libby P, Messerli FH, Redberg RF, Thadani U, Vaughn DE. Obesity, diabetes and the metabolic syndrome: the growing epidemic. Roundtable discussion. Today Cardiol. 2005; 8.
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Libby P. Panel discussion [CD]. In: State of the Art Symposium. Venous and Arterial Thrombosis: Recent Advances in Biology and Therapy. San Francisco, April 2005. 2005.
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Libby P. The pathogenesis of atherosclerosis. Kasper DL, Braunwald E, Fauci S, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s Principles of Medicine, 16th ed. 2005; 1425-1430.
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Macedo AV, Moffa PJ, Grupi CJ, Martinez Filho EE, Libby P, Guitierrez PS. Fatal myocardial infarction in a 88-year-old woman. Arq Bras Cardiol. 2005; 85:139-146.
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Libby P. The biology of inflammation: a common pathway in cardiovascular diseases, Part II. Textbook of Functional Medicine. 2005; 405-408.
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Genest J, Libby P, Gotto AM, Jr. Lipoprotein disorders and cardiovascular disease. Zipes DP, Libby P, Bonow RO, Braunwald E, editors. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 7th edition. 2005; 1013-1033.
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Varo N, Libby P, Nuzzo R, Italiano J, Doria A, Schönbeck U. Elevated release of sCD40L from platelets of diabetic patients by thrombin glucose and advanced glycation endproducts. Diabetes Vasc Dis Res. 2005; 2:81-87.
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Libby P. Pathophysiology of plaque rupture/erosion; unstable angina/non-ST elevation myocardial infarction. Lewis RP, editor. Adult Clinical Cardiology Self Assessment Program (ACCSAP), Vol. 6. 2005.
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Libby P. Inflammation to eruption: plaque and platelet. Evolving Management of Arterial Thrombosis: From Pathophysiology to Practice [Webcast]. 2005.
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Cannon CP, Libby P, Smith SC Jr., Ballantyne CM, editors. Advances in lipid management: AHA Scientific Sessions 2004 [monograph]. 2005.
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Rocha VZ, Libby P. Biologia vascular da aterosclerose e complicações agudas do ateroma [in Portuguese]. Nobre F, Serrano Jr., CV, editors. Tratado de Cardiologia. 2005; 541-554.
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Smith SC, Anderson JL, Cannon RO, Fadl YY, Koenig W, Libby P, Lipshultz SE, Mensah GA, Ridker PM, Rosenson R. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the clinical practice discussion group. Circulation. 2004 Dec 21; 110(25):e550-3.
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Nissen SE, Tuzcu EM, Libby P, Thompson PD, Ghali M, Garza D, Berman L, Shi H, Buebendorf E, Topol EJ. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial. JAMA. 2004 Nov 10; 292(18):2217-25.
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Aikawa M, Libby P. Lipid lowering therapy in atherosclerosis. Semin Vasc Med. 2004 Nov; 4(4):357-66.
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Krettek A, Sukhova GK, Schönbeck U, Libby P. Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells. Am J Pathol. 2004 Nov; 165(5):1571-81.
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Fukumoto Y, Deguchi JO, Libby P, Rabkin-Aikawa E, Sakata Y, Chin MT, Hill CC, Lawler PR, Varo N, Schoen FJ, Krane SM, Aikawa M. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation. 2004 Oct 5; 110(14):1953-9.
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Furukawa Y, Cole SE, Shah RV, Fukumoto Y, Libby P, Mitchell RN. Wild-type but not interferon-gamma-deficient T cells induce graft arterial disease in the absence of B cells. Cardiovasc Res. 2004 Aug 1; 63(2):347-56.
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Kinlay S, Schwartz GG, Olsson AG, Rifai N, Sasiela WJ, Szarek M, Ganz P, Libby P. Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study. Circulation. 2004 Jul 27; 110(4):386-91.
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Libby P, Willerson JT, Braunwald E. C-reactive protein and coronary heart disease. N Engl J Med. 2004 Jul 15; 351(3):295-8; author reply 295-8.
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Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest. 2004 Jul; 114(2):300-8.
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Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Jun 29; 109(25):3149-53.
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Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP. Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Aug; 24(8):1359-66.
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Schönbeck U, Libby P. Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents? Circulation. 2004 Jun 1; 109(21 Suppl 1):II18-26.
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Faxon DP, Fuster V, Libby P, Beckman JA, Hiatt WR, Thompson RW, Topper JN, Annex BH, Rundback JH, Fabunmi RP, Robertson RM, Loscalzo J. Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology. Circulation. 2004 Jun 1; 109(21):2617-25.
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Sugiyama S, Kugiyama K, Aikawa M, Nakamura S, Ogawa H, Libby P. Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis. Arterioscler Thromb Vasc Biol. 2004 Jul; 24(7):1309-14.
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Aikawa M, Libby P. The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach. Cardiovasc Pathol. 2004 May-Jun; 13(3):125-38.
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Aikawa M, Libby P. Atherosclerotic plaque inflammation: the final frontier? Can J Cardiol. 2004 May 1; 20(6):631-4.
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Buono C, Pang H, Uchida Y, Libby P, Sharpe AH, Lichtman AH. B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Apr 27; 109(16):2009-15.
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Libby P, Ridker PM. Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. Am J Med. 2004 Mar 22; 116 Suppl 6A:9S-16S.
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Libby P. Examining the dyslipidemia constellation: an interactive forum on new treatment advances. Introduction. Am J Med. 2004 Mar 22; 116 Suppl 6A:1S-2S.
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Feinberg MW, Shimizu K, Lebedeva M, Haspel R, Takayama K, Chen Z, Frederick JP, Wang XF, Simon DI, Libby P, Mitchell RN, Jain MK. Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. Circ Res. 2004 Mar 19; 94(5):601-8.
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Marx N, Walcher D, Raichle C, Aleksic M, Bach H, Grüb M, Hombach V, Libby P, Zieske A, Homma S, Strong J. C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. Arterioscler Thromb Vasc Biol. 2004 Mar; 24(3):540-5.
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Libby P, Hansson GK, Pober JS. Inflammation and immunity in atherogenesis. Chien KR, editor. Molecular basis of cardiovascular disease, 2nd ed.: a companion to Braunwald’s Heart Disease. 2004; 349-364.
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Libby P, Willerson JT. Introduction. Libby P, Willerson JT, editors. Vascular effects of statins. Circulation. 2004; 109 [suppl I]:II-1.
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Libby P, Chairman. Lp-PLA2 as an emerging biomarker in cardiovascular risk assessment [CD]. 2004.
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Cannon CP, Libby P, Smith SC Jr., editors. Coronary artery disease: AHA Scientific Sessions 2003. [monograph]. 2004.
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Hansson G, Libby P. The role of lymphocyte. Fuster V, Topol EJ, Nabel EG, editors. Atherothrombosis and coronary artery disease, 2nd edition. 2004; 521-528.
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Libby P. Frontiers: Inflammation [CD]. BBC Science Radio Unit. 2004.
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Assman G, Corsini A, Davignon J, Grundy SM, Libby P, März W, Mason RP, Nissen SE, Pedersen TR, Ridker PM, Riesen W, Schaefer EJ, Waters D. Summary of the expert panel meeting: Cholesterol-lowering with statins – are they all the same? International Task Force for the Prevention of Coronary Heart Disease [Webcast]. 2004.
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Raines E, Rosenfeld M, Libby P. The role of macrophages. Fuster V, Topol EJ, Nabel EG, editors. Atherothrombosis and coronary artery disease, 2nd edition. 2004; 505-520.
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Libby P. Clinical implications of vulnerable plaque [audio tape]. American College of Cardiology 53rd Annual Scientific Session. 2004.
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Libby P, Ridker PM. Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. Libby P, editor. Examining the dyslipidemia constellation; an interactive forum on new treatment advances. Proceedings of a symposium. Am J Med. 2004; 116 [suppl 6A]:9S-16S.
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Libby P. Angiotensin, inflammation, and atherogenesis [animated 5’8” video]. 2004.
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Balantyne C, Chapman J, Hughes E, Libby P, Reasner C, Schachter M, Betteridge J. Improved CV risk reduction: the evidence for raising HDL-C [CD]. Interviews and presentations from IDF Paris and ESC Vienna. 2004.
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Libby P. Progression of atherothrombosis. Part 1: the role of thrombosis. REACH Newsletter. 2004; 7 .
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Libby P. Vulnerable plaque [audio tape]. American College of Cardiology 53rd Annual Scientific Session. 2004.
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Libby P. The healthcare costs of gluttony and sloth. ESLM Lipid Letter. 2004; 4:1.
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Krettek A, Sukhova GK, Schoenbeck U, Libby P. Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm. Am J Pathol. 2004; 165:1571-1581.
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Blake G, Ridker PM, Libby P. Inflammatory markers. Fuster V, Topol EJ, Nabel EG, editors. Atherothrombosis and coronary artery disease, 2nd edition. 2004; 691-701.
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Libby P. Reducing the risk of atherosclerosis: the role of high-density lipoprotein cholesterol. Br J Cardiol. 2004; 11 [suppl 2]:S3-S6.
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Libby P. Interview [animated video]. 2004.
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Libby P. Vascular basis for statin action: implications for clinical practice [CD]. Gotto AM Jr., Libby P, Williams B, co-chairs. Lipids & BP management in intensive cardiovascular prevention. 2004.
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Libby P. How do we propose and prove the new concept and theory of the initiation and progress of atherosclerosis [interview (in Japanese)]. ACROSS. 2004; 7:14-17.
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Schönbeck U, Libby P. Cytokines and growth regulatory molecules. Fuster V, Topol EJ, Nabel EG, editors. Atherothrombosis and coronary artery disease, 2nd edition. 2004; 547-559.
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Gotto AM, Jr., Libby P. Updated ATP III guidelines: historical context and perspective on the future. ESLM Lipid Letter. 2004; 4:1.
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Libby P. Introduction. Libby P, editor. Examining the dyslipidemia constellation; an interactive forum on new treatment advances. Proceedings of a symposium. Am J Med. 2004; 116 [suppl 6A]:1S-2S.
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Libby P. . Inflammation and oxidative stress in cardiovascular disease: the role of angiotensin II blockade in the management of the cardiovascular continuum. Angiotensin Receptor Blockade: Setting the Standard for Treatment Across the Cardiovascular Continuum [Webcast]. 2004.
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Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation. 2003 Oct 14; 108(15):1772-8.
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Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation. 2003 Oct 7; 108(14):1664-72.
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Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation. 2003 Oct 28; 108(17):2113-20.
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Kinlay S, Schwartz GG, Olsson AG, Rifai N, Leslie SJ, Sasiela WJ, Szarek M, Libby P, Ganz P. High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study. Circulation. 2003 Sep 30; 108(13):1560-6.
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Libby P. Metformin and vascular protection: a cardiologist's view. Diabetes Metab. 2003 Sep; 29(4 Pt 2):6S117-20.
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Varo N, de Lemos JA, Libby P, Morrow DA, Murphy SA, Nuzzo R, Gibson CM, Cannon CP, Braunwald E, Schönbeck U. Soluble CD40L: risk prediction after acute coronary syndromes. Circulation. 2003 Sep 2; 108(9):1049-52.
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Libby P. Inflammatory markers are useful risk assessment tools. Am J Manag Care. 2003 Aug; Suppl:6-7.
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Suzuki J, Cole SE, Batirel S, Kosuge H, Shimizu K, Isobe M, Libby P, Mitchell RN. Tumor necrosis factor receptor -1 and -2 double deficiency reduces graft arterial disease in murine cardiac allografts. Am J Transplant. 2003 Aug; 3(8):968-76.
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Libby P. Bone marrow: a fountain of vascular youth? Circulation. 2003 Jul 29; 108(4):378-9.
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Lindsey ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa M, Libby P, Krane SM, Lee RT. Effect of a cleavage-resistant collagen mutation on left ventricular remodeling. Circ Res. 2003 Aug 8; 93(3):238-45.
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Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation. 2003 Jun 10; 107(22):2829-36.
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Varo N, Vicent D, Libby P, Nuzzo R, Calle-Pascual AL, Bernal MR, Fernández-Cruz A, Veves A, Jarolim P, Varo JJ, Goldfine A, Horton E, Schönbeck U. Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones. Circulation. 2003 Jun 3; 107(21):2664-9.
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Libby P, Zhao DX. Allograft arteriosclerosis and immune-driven angiogenesis. Circulation. 2003 Mar 11; 107(9):1237-9.
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Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906.
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Pan JH, Lindholt JS, Sukhova GK, Baugh JA, Henneberg EW, Bucala R, Donnelly SC, Libby P, Metz C, Shi GP. Macrophage migration inhibitory factor is associated with aneurysmal expansion. J Vasc Surg. 2003 Mar; 37(3):628-35.
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Krettek A, Sukhova GK, Libby P. Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis. Arterioscler Thromb Vasc Biol. 2003 Apr 1; 23(4):582-7.
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Libby P, Aikawa M. Mechanisms of plaque stabilization with statins. Am J Cardiol. 2003 Feb 20; 91(4A):4B-8B.
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Libby P. Vascular biology of atherosclerosis: overview and state of the art. Am J Cardiol. 2003 Feb 6; 91(3A):3A-6A.
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Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res. 2003 Mar 21; 92(5):493-500.
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Illingworth DR, Libby P, Rosenson RS, panelists. Salgo PL, moderator: Medical Crossfire. Realizing the goals of ATPIII: expanding aggressive treatment in high-risk patients [CD]. 2003.
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Libby P, Ridker PM, Pearson TA. The role of inflammatory markers in CVD: detection & treatment [CD]. 2003.
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Libby P. Preface. da Luz PL, editor. Endotélio e doenças cardiovasculares. 2003.
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Libby P. Molecular mechanisms of the acute coronary syndromes: the roles of inflammation and immunity. Theroux P, editor. Acute coronary syndromes: a companion to Braunwald’s Heart Disease. 2003; 80-87.
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Libby P. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): it’s not either/or” in hypertension therapy. Curr Atheroscler Rep. 2003; 5:199-200.
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Suzuki J, Cole SE, Batirel S, Shimizu K, Libby P, Mitchell RN. TNF receptor-1 and –2 double deficiency reduces graft arterial disease despite normal inflammatory cell IFN-? production. Am J Transplant. 2003; 3:968-976.
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Libby P. Inflammation: a common pathway in cardiovascular diseases. Dialogues Cardiovasc Med. 2003; 8:59-73.
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Illingworth DR, Libby P, Rosenson RS. Realizing the goals of ATP III: expanding the aggressive treatment in high-risk patients. Salgo L, moderator. Medical Crossfire. 2003; 4:3-21.
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Libby P. Cholesterol reduction and atherosclerosis: a look into the future [DVD]. 2003.
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Blake GJ, Ostfeld RJ, Yucel EK, Varo N, Schönbeck U, Blake MA, Gerhard M, Ridker PM, Libby P, Lee RT. Soluble CD40 ligand levels indicate lipid accumulation in carotid atheroma: an in vivo study with high-resolution MRI. Arterioscler Thromb Vasc Biol. 2003 Jan 1; 23(1):e11-4.
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Libby P, Aikawa M. Effects of statins in reducing thrombotic risk and modulating plaque vulnerability. Clin Cardiol. 2003 Jan; 26(1 Suppl 1):I11-4.
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Blake GJ, Ostfeld RJ, Yucel EK, Varo N, Schönbeck U, Blake MA, Gerhard M, Ridker PM, Libby P, Lee RT. Soluble CD40 ligand levels indicate lipid accumulation in carotid atheroma: an in vivo study using high-resolution MRI. Arterioscler Thromb Vasc Biol. 2003; 23:E11-E14.
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Libby P. Acute coronary syndromes and hyperlipidemia [DVD]. 2003.
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Libby P. The vulnerable patient: looking beyond the heart [editorial]. ESLM Lipid Letter. 2003; 3:1,8.
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Henney A, Libby P. Professor Michael John Davies [appreciation]. Circulation. 2003; 108:124-125.
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Libby P, Simon DI, Rogers C. Inflammation and arterial injury. Topol EJ, editor. Textbook of interventional cardiology, 4th ed. 2003; 381-389.
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Libby P. The macrophage and the atherosclerotic process: risk factors and treatment. Wilson PWF, editor. Atlas of Atherosclerosis, 3rd ed. 2003; 41-49.
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Libby P. CRP in risk management [editorial]. ESLM Lipid Letter. 2003; 2:1,7.
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Libby P. Inflammation: its role in atherogenesis [animated 7’4” video]. 2003.
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Libby P. The role of inflammation in atherogenesis and in guiding therapy of atherosclerosis. Adv Stud Med. 2003; 3:S311-S314.
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Libby P. From vascular biology to vascular pathophysiology [audio tape]. American College of Cardiology 52rd Annual Scientific Session. 2003.
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Libby P. Inflammation and atherogenesis: novel therapeutic targets [CD]. In Merck Symposium: Inflammation and Cardiovascular Disease: From Theory to Clinic. 2003.
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Feuerstein GZ, Libby P, Mann DL. Summary: Immune and inflammatory modulators as potential therapeutic targets for cardiac diseases. Feuerstein GZ, Libby P, Mann DL, editors. Inflammation and Cardiac Disease. 2003; 407-409.
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Libby P. The role of inflammatory markers in CVD: detection & treatment [monograph]. 2003.
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Feuerstein GZ, Firestein R, Mann DL, Libby P. A biomarker of inflammation in cardiovascular diseases. Feuerstein GZ, Libby P, Mann DL, editors. Inflammation and Cardiac Disease. 2003; 9-20.
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Plutzky J, Libby P. Pathophysiology of atherosclerotic heart disease. Tonkin AM, editor. Atherosclerosis and heart disease. 2003; 1-12.
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Libby P, Waters DD, Fonarow GC, Selwyn AP, editors. Integrating lipid therapy into ACS critical pathways: merging mechanisms with management [monograph]. 2003.
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Blake GJ, Ostfeld RJ, Yucel EK, Varo N, Schönbeck U, Blake MA, Gerhard M, Ridker PM, Libby P, Lee RT. In response. Circulation. 2003; 23:1130-1131.
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De Caterina R, Libby P. Arteriosclerosi: basi molecolari e meccanismi d’azione dei fattori di rischio. Medicina Clinica: Basi Biologiche Diagnostica Terapia. 2003; 1:Chap. IX.
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Feuerstein GZ, Libby P, Mann DL. Inflammation—a new frontier in cardiac disease and therapeutics. Feuerstein GZ, Libby P, Mann DL, editors. Inflammation and Cardiac Disease. 2003; 1-5.
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Libby P. Vascular biology of atherosclerosis: overview and state of the art. Franciosa JA, Alexander RW, editors. A symposium: biology of atherosclerosis and its implications for treatment strategies. Am J Cardiol. 2003; 91:3A-6A.
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Kalayoglu MV, Libby P, Byrne GI. Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease. JAMA. 2002 Dec 4; 288(21):2724-31.
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Schönbeck U, Gerdes N, Varo N, Reynolds RS, Horton DB, Bavendiek U, Robbie L, Ganz P, Kinlay S, Libby P. Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells. Circulation. 2002 Dec 3; 106(23):2888-93.
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Libby P. Inflammation in atherosclerosis. Nature. 2002 Dec 19-26; 420(6917):868-74.
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Libby P, Plutzky J. Diabetic macrovascular disease: the glucose paradox? Circulation. 2002 Nov 26; 106(22):2760-3.
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Libby P, Aikawa M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat Med. 2002 Nov; 8(11):1257-62.
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Young JL, Libby P, Schönbeck U. Cytokines in the pathogenesis of atherosclerosis. Thromb Haemost. 2002 Oct; 88(4):554-67.
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Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation. 2002 Sep 24; 106(13):1708-15.
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Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002 Sep 10; 106(11):1390-6.
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Takayama K, García-Cardena G, Sukhova GK, Comander J, Gimbrone MA, Libby P. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem. 2002 Nov 15; 277(46):44147-54.
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Sukhova GK, Williams JK, Libby P. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol. 2002 Sep 1; 22(9):1452-8.
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Geng YJ, Libby P. Progression of atheroma: a struggle between death and procreation. Arterioscler Thromb Vasc Biol. 2002 Sep 1; 22(9):1370-80.
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Hansson GK, Libby P, Schönbeck U, Yan ZQ. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002 Aug 23; 91(4):281-91.
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Zhao DX, Hu Y, Miller GG, Luster AD, Mitchell RN, Libby P. Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and acute rejection. J Immunol. 2002 Aug 1; 169(3):1556-60.
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Schönbeck U, Sukhova GK, Gerdes N, Libby P. T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm. Am J Pathol. 2002 Aug; 161(2):499-506.
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Sakash JB, Byrne GI, Lichtman A, Libby P. Cytokines induce indoleamine 2,3-dioxygenase expression in human atheroma-asociated cells: implications for persistent Chlamydophila pneumoniae infection. Infect Immun. 2002 Jul; 70(7):3959-61.
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Higuchi ML, Gutierrez PS, Bezerra HG, Palomino SA, Aiello VD, Silvestre JM, Libby P, Ramires JA. Comparison between adventitial and intimal inflammation of ruptured and nonruptured atherosclerotic plaques in human coronary arteries. Arq Bras Cardiol. 2002 Jul; 79(1):20-4.
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Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002 May 15; 287(19):2570-81.
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Libby P. Extending knowledge of the benefits of statins: The Heart Protection Study. Curr Atheroscler Rep. 2002 May; 4(3):211-2.
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Libby P. Atherosclerosis: the new view. Sci Am. 2002 May; 286(5):46-55.
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Bavendiek U, Libby P, Kilbride M, Reynolds R, Mackman N, Schönbeck U. Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1. J Biol Chem. 2002 Jul 12; 277(28):25032-9.
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Marx N, Kehrle B, Kohlhammer K, Grüb M, Koenig W, Hombach V, Libby P, Plutzky J. PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res. 2002 Apr 5; 90(6):703-10.
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Libby P, Aikawa M. Vitamin C, collagen, and cracks in the plaque. Circulation. 2002 Mar 26; 105(12):1396-8.
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Baim D, Brady TJ, Casscells SW, Dunne M, Fayad Z, Fuster V, Gazelle S, Heldman A, Hatsukami T, Kinlay S, Lafont A, Lee R, Libby P, Meier B, Muller JE, Naghavi M, O'Donnell C, Perin E, Rekhter M, Rumberger J, Russell M, Schwartz R, Selwyn A, Strauss HW, Tearney G, Tomaru T, Tuzcu EM, Wasserman B. Thoughts on the role of the healing professions and the events of September 11, 2001. Circulation. 2002 Mar 26; 105(12):1509-10.
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Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002 Mar 5; 105(9):1135-43.
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Furukawa Y, Libby P, Stinn JL, Becker G, Mitchell RN. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts. Am J Pathol. 2002 Mar; 160(3):1077-87.
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Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT. Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation. 2002 Feb 12; 105(6):753-8.
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Gerdes N, Sukhova GK, Libby P, Reynolds RS, Young JL, Schönbeck U. Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. J Exp Med. 2002 Jan 21; 195(2):245-57.
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Mach F, Sukhova GK, Michetti M, Libby P, Michetti P. Influence of Helicobacter pylori infection during atherogenesis in vivo in mice. Circ Res. 2002 Jan 11; 90(1):E1-4.
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Libby P. Science, evidence, guidelines: advancing dyslipidemia care [audio tape]. 2002.
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Bakris GL, Blumenthal RS, Konstam MA, Libby P, Lucchesi BR, Nissen SE, Willerson J, Cooper-DeHoff RM. The safety of COX-2 inhibitors in patients with CHD. Round table discussion (Part II), Pepine CJ, moderator. Today in Cardiology. 2002; 5:5-10.
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Libby P. Lipid-lowering therapy stabilizes plaque, reduces events by limiting inflammation. Am J Manag Care. 2002 Jan; Suppl:1, 4.
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Libby P. Reverse cholesterol transport [animated 1’49” video]. Changes and challenges in cardiovascular protection. 2002.
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Libby P, Deanfield JE, editors. Atherosclerosis and vascular disease: a mechanistic framework for CV risk management [monograph]. 2002.
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Libby P. Multiple risk factors for atherogenesis [animated 7’55” video]. 2002.
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Libby P. New insights into the pathogenesis of the acute coronary syndromes and lipid lowering. Baylor Coll Med Reports Dyslipidemias. 2002; 1:1-12.
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Bakris GL, Blumenthal RS, Konstam MA, Libby P, Lucchesi BR, Nissen SE, Willerson J, Cooper-DeHoff RM. The safety of COX-2 inhibitors in patients with CHD. Round table discussion (Part I), Pepine CJ, moderator. Cardiology Today. 2002; 5:5-8.
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Libby P. Diabetic dyslipidemia [animated 2’3” video]. Changes and challenges in cardiovascular protection. 2002.
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Libby P. Plaque instability and acute events [animated 1’45” video]. Changes and challenges in cardiovascular protection. 2002.
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Schönbeck U, Libby P. Matrix metalloproteinases and their inhibitors. Fuster V, editor. Assessing and modifying the vulnerable atherosclerotic plaque. 2002; 335-345.
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Plutzky J, Libby P. Type 2 diabetes and the heart [CD]. 2002.
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Libby P. Aldosterone and inflammation: a new understanding of hypertensive cardiovascular damage [CD]. American Heart Association, 75th Scientific Sessions. 2002.
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Libby P. Acute coronary syndromes and hyperlipidemia [animated 6’40” video, updated 2003]. 2002.
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Bavendiek U, Libby P, Kilbride M, Reynolds R, Mackman N, Schönbeck U. Induction of tissue factor expression in human endothelial cells by CD40-ligand is mediated via activator protein 1, nuclear factor ?B, and Egr-1. J Biol Chem. 2002; 277:25032-25039.
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Gotto AM Jr., Libby P, editors. Evidence supporting lipid-lowering therapy to reduce coronary risk: a focus of special populations [monograph]. 2002.
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Libby P. Use of genomics to discover new targets for therapy [CD]. National Lipid Education Council annual update meeting: Evolving issues in the management of CHD. 2002.
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Libby P. Atherothrombosis from the inside out: the latest findings and imaging techniques. A Case-based Symposium. Beyond the Acute Phase: Long-Term Management Post Intervention [Webcast]. 2002.
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Zhao X-M, Hu Y, Miller GG, Luster AD, Mitchell RN, Libby P. Differential expression of IFN-?-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell ? chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and acute rejection. J Immunol. 2002; 169:1556-1560.
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Libby P. Atherosclerosis [animated 1’37” video]. Changes and challenges in cardiovascular protection. 2002.
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Libby P, Ridker PM, Maseri A. Inflammation in atherosclerosis [review]. Circulation. 2002; 105:1135-1143.
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Gotto, AM, Jr., Libby P. Mounting evidence supports lipid strategies post-ACS [editorial]. ESLM Lipid Letter. 2002; 1:1 .
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Libby P, editor. Vascular biology section. Curr Atheroscler Rep. 2002; 4:207-251.
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Libby P. A new blood test to predict heart disease: measures the level of C-reactive protein [animated 6’ video]. 2002.
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Libby P. Novel inflammatory pathways in atherogenesis [CD]. Plenary session III, 6th International Symposium of Global Risk of Coronary Heart Disease and Stroke: Assessment, Prevention, and Treatment. Florence, Italy, June 12-15, 2002. 2002.
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Libby P. Inflammation: its role in atherogenesis [CD]. 2002.
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Libby P. Metabolic syndrome, diabetes, and atherogenesis [animated 1’14” video]. Changes and challenges in cardiovascular protection. 2002.
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Libby P. Vascular biology of the thrombotic complications of atherothrombosis [CD]. National Summit on Atherothrombosis, Naples, FL, April 2002. 2002.
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Higuchi MdL, Bezerra HG, Palomino SAP, Gutierrez P, Aiello VD, Silvestre JML, Libby P, Ramires JAF. A role for chronic adventitial inflammation in positive arterial remodeling and atheroma instability. Arq Bras Cardiol. 2002; 79:20-24.
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Libby P. The role of HDL-C in atherogenesis and cardiovascular disease [CD]. 2002.
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Gotto, AM, Jr., Libby P. Impact of the Heart Protection Study [editorial]. ESLM Lipid Letter. 2002; 2:1-3.
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Libby P. Inflammatory processes in the development and progression of atherosclerosis [CD]. Transcatheter Cardiovascular Therapeutics, 14th Annual Scientific Sessions, Washington, DC, September 24-28, 2002. 2002.
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Libby P. The role of HDL-C in atherogenesis and cardiovascular disease [animated video]. 2002.
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Libby P. Major pharmacologic pathways of cholesterol modification [animated 1’54” video]. Changes and challenges in cardiovascular protection. 2002.
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Libby P. The role of HDL-C in atherogenesis and cardiovascular disease [CD]. American College of Cardiology Symposium on the Evolving Relationship Between Lipoproteins and Cardiovascular Risk: The Role of Statins. 2002.
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Libby P. The lipoprotein menagerie [animated 1’39” video]. Changes and challenges in cardiovascular protection. 2002.
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Libby P, Gordon MB. Atherosclerosis. Lilly LS, editor. Pathophysiology of heart disease: a collaborative project of medical students and faculty, 3rd edition. 2002; 111-130.
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Libby P. Foreword. Goldhaber SZ, Ridker PM, editors. Thrombosis and thromboembolism. 2002; vii-viii.
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Libby P. Inflammation and atherogenesis: novel therapeutic targets [Webcast]. 2002.
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Sakash JB, Byrne G, Lichtman A, Libby P. Cytokines induce indoleamine 2,3-dioxygenase expression in human atheroma-associated cells: implications for persistent Chlamydia pneumoniae infection. Infect Immunol. 2002; 70:359-361.
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Libby P, Aikawa M. Mechanisms of plaque stability and stabilization. Ther Res. 2002; 23:2387-2428.
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Libby P. Managing the risk of atherosclerosis: the role of high-density lipoprotein. Am J Cardiol. 2001 Dec 20; 88(12A):3N-8N.
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Schönbeck U, Libby P. CD40 signaling and plaque instability. Circ Res. 2001 Dec 7; 89(12):1092-103.
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Horton DB, Libby P, Schonbeck U. Ligation of CD40 onvascular smooth muscle cells mediates loss of interstitial collagen via matrix metalloproteinase activity. Ann N Y Acad Sci. 2001 Dec; 947:329-36.
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Robbie L, Libby P. Inflammation and atherothrombosis. Ann N Y Acad Sci. 2001 Dec; 947:167-79; discussion 179-80.
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Rabkin E, Aikawa M, Stone JR, Fukumoto Y, Libby P, Schoen FJ. Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation. 2001 Nov 20; 104(21):2525-32.
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Schönbeck U, Varo N, Libby P, Buring J, Ridker PM. Soluble CD40L and cardiovascular risk in women. Circulation. 2001 Nov 6; 104(19):2266-8.
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Herman MP, Sukhova GK, Libby P, Gerdes N, Tang N, Horton DB, Kilbride M, Breitbart RE, Chun M, Schönbeck U. Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling. Circulation. 2001 Oct 16; 104(16):1899-904.
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Libby P. What have we learned about the biology of atherosclerosis? The role of inflammation. Am J Cardiol. 2001 Oct 11; 88(7B):3J-6J.
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O'Connor S, Taylor C, Campbell LA, Epstein S, Libby P. Potential infectious etiologies of atherosclerosis: a multifactorial perspective. Emerg Infect Dis. 2001 Sep-Oct; 7(5):780-8.
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Libby P, Schönbeck U. Drilling for oxygen: angiogenesis involves proteolysis of the extracellular matrix. Circ Res. 2001 Aug 3; 89(3):195-7.
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Marx N, Libby P, Plutzky J. Peroxisome proliferator-activated receptors (PPARs) and their role in the vessel wall: possible mediators of cardiovascular risk? J Cardiovasc Risk. 2001 Aug; 8(4):203-10.
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Kinlay S, Libby P, Ganz P. Endothelial function and coronary artery disease. Curr Opin Lipidol. 2001 Aug; 12(4):383-9.
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Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation. 2001 Jul 17; 104(3):365-72.
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Sakamoto H, Aikawa M, Hill CC, Weiss D, Taylor WR, Libby P, Lee RT. Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension. Circulation. 2001 Jul 3; 104(1):109-14.
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Bezerra HG, Higuchi ML, Gutierrez PS, Palomino SA, Silvestre JM, Libby P, Ramires JA. Atheromas that cause fatal thrombosis are usually large and frequently accompanied by vessel enlargement. Cardiovasc Pathol. 2001 Jul-Aug; 10(4):189-96.
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Libby P, Aikawa M. Evolution and stabilization of vulnerable atherosclerotic plaques. Jpn Circ J. 2001 Jun; 65(6):473-9.
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Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. Nat Med. 2001 Jun; 7(6):738-41.
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Herman MP, Sukhova GK, Kisiel W, Foster D, Kehry MR, Libby P, Schönbeck U. Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis. J Clin Invest. 2001 May; 107(9):1117-26.
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Libby P, Simon DI. Inflammation and thrombosis: the clot thickens. Circulation. 2001 Apr 3; 103(13):1718-20.
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Libby P, Pober JS. Chronic rejection. Immunity. 2001 Apr; 14(4):387-97.
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Sugiyama S, Okada Y, Sukhova GK, Virmani R, Heinecke JW, Libby P. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol. 2001 Mar; 158(3):879-91.
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Fukumoto Y, Libby P, Rabkin E, Hill CC, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits. Circulation. 2001 Feb 20; 103(7):993-9.
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De Caterina R, Bourcier T, Laufs U, La Fata V, Lazzerini G, Neish AS, Libby P, Liao JK. Induction of endothelial-leukocyte interaction by interferon-gamma requires coactivation of nuclear factor-kappaB. Arterioscler Thromb Vasc Biol. 2001 Feb; 21(2):227-32.
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Zhao XM, Hu Y, Miller GG, Mitchell RN, Libby P. Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts. Circulation. 2001 Jan 30; 103(4):525-31.
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Lee RT, Yamamoto C, Feng Y, Potter-Perigo S, Briggs WH, Landschulz KT, Turi TG, Thompson JF, Libby P, Wight TN. Mechanical strain induces specific changes in the synthesis and organization of proteoglycans by vascular smooth muscle cells. J Biol Chem. 2001 Apr 27; 276(17):13847-51.
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Aikawa M, Rabkin E, Sugiyama S, Voglic SJ, Fukumoto Y, Furukawa Y, Shiomi M, Schoen FJ, Libby P. An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation. 2001 Jan 16; 103(2):276-83.
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Marx N, Mackman N, Schönbeck U, Yilmaz N, Hombach V, Libby P, Plutzky J. PPARalpha activators inhibit tissue factor expression and activity in human monocytes. Circulation. 2001 Jan 16; 103(2):213-9.
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Schönbeck U, Libby P. CD40 and CD40 L (CD154). Creighton TE, editor. Encyclopedia of molecular medicine. 2001; 608-612.
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Creager MA, Libby P. Peripheral arterial diseases. Braunwald E, Zipes DP, Libby P, editors. Heart disease: a textbook of cardiovascular medicine, 6th ed. 2001; 1457-1484.
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Robbie L, Libby P. Inflammation and atherothrombosis. Saratoga Conference 2001. Ann NY Acad Sci. 2001; 947:167-180.
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Libby P, Aikawa M. Evolution and stabilization of vulnerable atherosclerotic plaques [review]. Japan Circ J. 2001; 65:473-479.
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Libby P. Mechanistic effect of aggressive lipid lowering on ACS [CD]. National Lipid Education Council annual update meeting: Exploring the continuum of CHD risk. 2001.
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Ridker PM, Genest J, Libby P. Risk factors for atherosclerotic disease. Braunwald E, Zipes DP, Libby P, editors. Heart disease: a textbook of cardiovascular medicine, 6th ed. 2001; 1010-1039.
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Herman MP, Sukhova GK, Foster D, Kisiel W, Kehry M, Libby P, Schönbeck U. Tissue factor pathway inhibitor-2: A novel inhibitor of active MMPs with implications for atherosclerosis. J Clin Invest. 2001; 107:1117-1126.
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Libby P . New concepts in plaque biology [CD]. American Heart Association, 73rd Scientific Sessions. 2001.
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Libby P, Simon D. Thrombosis and atherosclerosis. Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN, editors. Hemostasis and thrombosis: basic principles and clinical practice, 4th ed. 2001; 743-752.
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Libby P. Prevention and treatment of atherosclerosis. Braunwald E, Fauci S, Kasper DL, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s principles of internal medicine, 15th ed. 2001; 1382-1386.
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Libby P. Statins, arterial wall, and vascular interaction [CD]. Consensus on Statins 2001. 2001.
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Libby P, Simon DI. Multiple mechanisms of arterial thrombosis [CD]. STRIVE: Acute coronary syndromes grand rounds lecture. 2001.
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Libby P, editor. Vascular biology section. In Gotto AM, Jr., Olsson AG, editors. Curr Atheroscler Rep. 2001; 3:224-266.
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Libby P, Deanfield JE, editors. Targeting global risk in the management of atherosclerosis and vascular disease [monograph]. 2001.
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Libby P. Statins: therapeutic benefits in vascular disease [animated 8'48" video]. 2001.
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Libby P, Nissen SE, Pitt B, editors. Intervention to prevention: evolving atherosclerosis management [CD]. Faculty lecture kit. 2001.
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Libby P. The pathogenesis of atherosclerosis. Braunwald E, Fauci S, Kasper DL, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s principles of internal medicine, 15th ed. 2001; 1377-1382.
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Brown WV, Assman G, Ballantyne CM, Gotto AM, Libby P, Olsson AG, Stein EA. Current issues in dyslipidemia: Advice from the experts [CD]. Brown WV, Chairman. 2001.
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Plutzky J, Marx N, Libby P. Perixosome proliferator-activated receptors (PPARs) and their role in the vessel wall: possible mediators of cardiovascular risk? [review]. J Cardiovasc Risk. 2001; 8:203-210.
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Nesto, R, Libby P. Diabetes mellitus and the cardiovascular system. Braunwald E, Zipes DP, Libby P, editors. Heart disease: a textbook of cardiovascular medicine. 2001; 2133-2150.
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Libby P. La plaque athéromateuse: Mécanismes de la rupture et des complications. Vacheron A, editor. La cardiologie à l’aube du troisème millénaire. 2001; 33-49.
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Aikawa M, Libby P. Vascular inflammation and activation: new targets for lipid lowering [review]. Eur Heart J. 2001; 3 [Suppl B]:B3-B11.
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Libby P, Pitt B, editors. Evolving atherosclerosis management [monograph]. 2001.
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Libby P, Epstein M, Kuritzky L. Managing multiple CV risk factors in primary care: An interactive workshop [CD]. 2001.
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Libby P. The vascular biology of atherosclerosis. Braunwald E, Zipes DP, Libby P, editors. Heart disease: a textbook of cardiovascular medicine, 6th ed. 2001; 995-1009.
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Libby P. Statins: Therapeutic benefits in vascular disease [CD]. APOLLO. 2001.
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Libby P. Advances in cardiology: The new biology of atherosclerosis and its complications. ESLM Lipid Letter. 2001; 1:4-5.
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Schönbeck U, Libby P. The CD40/CD154 receptor/ligand dyad. Cell Mol Life Sci. 2001 Jan; 58(1):4-43.
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Horton DB, Libby P, Schönbeck U. Ligation of CD40 on vascular smooth muscle cells mediates loss of interstitial collagen via matrix metalloproteinase activity. Ann NY Acad Sci. 2001; 947:329-336.
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Libby P, Simon DI. Acute coronary syndromes: thrombosis [animated video]. 2001.
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Stone RM, Bridges K, Libby P. Hematological-oncological disorders and heart disease. Braunwald E, Zipes DP, Libby P, editors. Heart disease: a textbook of cardiovascular medicine, 6th ed. 2001; 2223-2243.
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Libby P. Dyslipidemia and atheroma in the young [commentary]. Lipid Management. 2001; 5:5 .
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Libby P, Braunwald E, De Sanctis RW. Thomas Woodward Smith. In Memorium. 2001; 3.
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Libby P, Gotto AM, Jr. ATP III: Translating a scientific achievement into improved patient care [editorial]. ESLM Lipid Letter. 2001; 1:1 .
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Schoenbeck U, Libby P. The CD40/CD154 receptor/ligand dyad [review]. In special issue honoring Konrad Bloch, MD. Cell Mol Life Sci. 2001; 58:4-43.
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Libby P. Biomechanical and cellular basis of the vulnerable plaque [CD]. CMIT 2001 Vulnerable Plaque Conference on Pathophysiology, Detection, and Treatment. Libby P, Muller JE, Fuster V, Chairmen. 2001.
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Libby P. Beyond lipids: the potential of screening tools for improving primary prevention [editorial]. ESLM Lipid Letter. 2001; 1:1 .
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Libby P, Aikawa M, Schönbeck U. Cholesterol and atherosclerosis. Biochim Biophys Acta. 2000 Dec 15; 1529(1-3):299-309.
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Libby P, Dzau VJ. In memoriam : arthur Mu-En Lee Circ Res. 2000 Nov 10; 87(10):831-2.
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Libby P. Multiple mechanisms of thrombosis complicating atherosclerotic plaques. Clin Cardiol. 2000 Nov; 23 Suppl 6:VI-3-7.
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Haley KJ, Lilly CM, Yang JH, Feng Y, Kennedy SP, Turi TG, Thompson JF, Sukhova GH, Libby P, Lee RT. Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. Circulation. 2000 Oct 31; 102(18):2185-9.
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Libby P. Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization. Am J Cardiol. 2000 Oct 19; 86(8B):3J-8J; discussion 8J-9J.
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Libby P, Lee RT. Matrix matters. Circulation. 2000 Oct 17; 102(16):1874-6.
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Lee RT, Libby P. Matrix metalloproteinases: not-so-innocent bystanders in heart failure. J Clin Invest. 2000 Oct; 106(7):827-8.
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Shimizu K, Schönbeck U, Mach F, Libby P, Mitchell RN. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis. J Immunol. 2000 Sep 15; 165(6):3506-18.
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Furukawa Y, Mandelbrot DA, Libby P, Sharpe AH, Mitchell RN. Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. Am J Pathol. 2000 Aug; 157(2):473-84.
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Schönbeck U, Mach F, Libby P. CD154 (CD40 ligand). Int J Biochem Cell Biol. 2000 Jul; 32(7):687-93.
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Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest. 2000 Jul; 106(1):55-62.
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Libby P, Aikawa M, Kinlay S, Selwyn A, Ganz P. Lipid lowering improves endothelial functions. Int J Cardiol. 2000 Jun 30; 74 Suppl 1:S3-S10.
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Schönbeck U, Sukhova GK, Shimizu K, Mach F, Libby P. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7458-63.
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Marx N, Mach F, Sauty A, Leung JH, Sarafi MN, Ransohoff RM, Libby P, Plutzky J, Luster AD. Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol. 2000 Jun 15; 164(12):6503-8.
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Byrne GI, Skarlotos SI, Grunfeld C, Kalayoglu MV, Libby P, Saikku P, Summersgill JT, Wyrick P. Collaborative multidisciplinary workshop report: interface of lipid metabolism, atherosclerosis, and Chlamydia infection. J Infect Dis. 2000 Jun; 181 Suppl 3:S490-1.
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Aikawa M, Libby P. Lipid lowering reduces proteolytic and prothrombotic potential in rabbit atheroma. Ann N Y Acad Sci. 2000 May; 902:140-52.
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Young JL, Sukhova GK, Foster D, Kisiel W, Libby P, Schönbeck U. The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J Exp Med. 2000 May 1; 191(9):1535-44.
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Libby P. Changing concepts of atherogenesis. J Intern Med. 2000 Mar; 247(3):349-58.
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Abi-Younes S, Sauty A, Mach F, Sukhova GK, Libby P, Luster AD. The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques. Circ Res. 2000 Feb 4; 86(2):131-8.
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Fabunmi RP, Moore KJ, Libby P, Freeman MW. Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice. Atherosclerosis. 2000 Feb; 148(2):375-86.
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Bourcier T, Libby P. HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells. Arterioscler Thromb Vasc Biol. 2000 Feb; 20(2):556-62.
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Libby P. "The endothelium: A target for vascular health" [CD]. Global Management of the High-Risk Patient: Annual Update 2000. National Lipid Education Council. 2000.
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Libby P. "The vulnerable plaque: 1999 update" [CD]. American Heart Association, 72nd Scientific Sessions. 2000.
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Libby P. Coronary artery injury and the biology of atherosclerosis: Inflammation, thrombosis, and stabilization. Waters DD, Libby P, editors. A symposium: new directions in the understanding and management of acute coronary syndromes. 2000; 86 [Suppl]:3J-9J.
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Libby P. "The endothelium: A target for vascular health" [CD]. Global Management of the High-Risk Patient: Annual Update 2000. National Lipid Education Council. 2000.
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Libby P. Anti-atherogenic mechanisms of high density lipoprotein (HDL-C) [animated 12' video]. 2000.
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Kol A, Lichtman AH, Finberg RW, Libby P, Kurt-Jones EA. Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells. J Immunol. 2000 Jan 1; 164(1):13-7.
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De Caterina R, Liao JK, Libby P. Fatty acid modulation of endothelial activation. Am J Clin Nutr. 2000 Jan; 71(1 Suppl):213S-23S.
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Libby P, Dzau VJ. In memorium: Arthur Mu-En Lee. Circ Res. 2000; 87:831-832.
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Libby P, Aikawa M, Schönbeck U. Cholesterol and atherosclerosis. Molecular and Cell Biology of Lipids Special Issue: Cholesterol 2000 (Festschrift issue in honor of Konrad Bloch). Biochim Biophys Acta. 2000; 1529:299-309.
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Aikawa M, Fukumoto Y, Rabkin E, Libby P. Rabbit models of atherosclerosis. Simon DI, Rogers C, editors. Contemporary cardiology: vascular disease and injury: preclinical research. 2000; 175-191.
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Libby P, Aikawa M, Schoenbeck U, Sukhova GK, Mach F, Marx N, Plutzky J. Inflammation and plaque stability. Stemme S, Olsson AG, editors. Atherosclerosis XII. Excerpta Medica International Congress Series 1215. 2000; 67-80.
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De Caterina R, Libby P. L'attivazione e la patogensi dell'aterosclerosi. De Caterina R, editor. Attivazione endoteliale e aterosclerosi. 2000; 17-40.
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Young J, Sukhova GK, Foster D, Kisiel W, Libby P, Schoenbeck U. The serpin PI-9 is an endogenous inhibitor of Interleukin-1?-converting enzyme (Caspase-1). J Exp Med. 2000; 191:1535-1544.
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Libby P. "Modifying approaches" [CD]. (Includes video) Scientific Conference: Assessing and Modifying the Vulnerable Atherosclerotic Plaque. 2000.
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Schönbeck U, Mach F, Sukhova GK, Herman M, Graber P, Kehry MR, Libby P. CD40 ligation induces tissue factor expression in human vascular smooth muscle cells. Am J Pathol. 2000 Jan; 156(1):7-14.
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Waters DD, Libby P, editors. A symposium: new directions in the understanding and management of acute coronary syndromes. Am J Cardiol. 2000; 86 [Suppl].
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Libby P. Lipid lowering and the acute coronary syndromes [animated 6' video]. 2000.
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Libby P. "White cells, monocytes, and macrophages in arterial disease" [CD]. The 32nd Annual New York Cardiovascular Symposium: Challenges in Coronary Artery Disease, Vol. 1. 2000.
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Schoenbeck U, Mach F, Libby P. Molecules in focus: CD154 (CD40 ligand) [review]. Int J Biochem Cell Biol. 2000; 32:687-693.
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Libby P. Multiple mechanisms of thrombosis complicating atherosclerotic plaques. King SB III, Montalescot G, editors. Reducing the risk of vascular disease: antiplatelet therapy in the new millennium. Clin Cardiol. 2000; 23:V13-V17.
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Libby P. Heart failure [animated 1'43" video]. 2000.
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Libby P, Aikawa M, Schönbeck U. Cholesterol and atherosclerosis. Molecular and Cell Biology of Lipids Special Issue: Cholesterol 2000 (Festschrift issue in honor of Konrad Bloch). Biochim Biophys Acta. 2000; 1529:299-309.
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Libby P. The acute coronary syndromes: have our tools constrained our thinking? [review]. Gould L, editor. The past and the present: prologues to the future. ACC Current Journal Review. 2000; 9:20-22.
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Libby P. Pulse pressure [animated 1'40" video]. 2000.
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Libby P. La Théorie infectieuse dans la genèse de la plaque d'athérome [CD]. American Heart Association Planète Congrès. 2000.
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Libby P. HDL-C and reducing the risk of atherosclerosis: a mechanistic review. Cook S, editor. HDL cholesterol: the missing link in cardiovascular risk reduction. Clinician. 2000; 18:3-8.
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Libby P. The progress and promise of the endothelial biology of atherosclerosis. Preface to: De Caterina R, editor. Attivazione endoteliale e aterosclerosi. 2000; XIII-XIV.
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Libby P, Lee RT. Matrix matters [editorial]. Circulation. 2000; 102:1874-1876.
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Libby P. Atherosclerosis: An inflammatory disease. Plutzky J, Libby P, Nakamura H, editors. Second US-Japanese dialogue on lipid disorders and coronary heart disease. 2000; 27-31.
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Libby P, Ganz P, Schoen FJ, Lee RT. The vascular biology of the acute coronary syndromes. Topol EJ, editor. Acute coronary syndromes, 2nd ed. 2000; 33-57.
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Shimizu K, Schoenbeck U, Mach F, Libby P, Mitchell RN. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation, but does not prevent graft arteriosclerosis. J Immunol. 2000; 165:3506-3518.
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Libby P. Atherosclerosis and infection [animated 4' video]. 2000.
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Marx N, Mach F, Sauty A, Leung JH, Sarafi MN, Ransohoff RM, Libby P, Plutzky J, Luster AD. Peroxisome proliferator-activated receptor-? activators inhibit IFN-?-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol. 2000; 164:6503-6508.
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Libby P. The macrophage and atherosclerotic process. Wilson P, editor. Atlas of atherosclerosis: risk factors and treatment, 2nd ed. 2000; 41-49.
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Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling?concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 2000; 35:569-582.
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Furukawa Y, Becker G, Stinn JL, Shimizu K, Libby P, Mitchell RN. Interleukin-10 (IL-10) augments allograft arterial disease: paradoxical effects of IL-10 in vivo. Am J Pathol. 1999 Dec; 155(6):1929-39.
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Feng Y, Yang JH, Huang H, Kennedy SP, Turi TG, Thompson JF, Libby P, Lee RT. Transcriptional profile of mechanically induced genes in human vascular smooth muscle cells. Circ Res. 1999 Dec 3-17; 85(12):1118-23.
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Kol A, Libby P. Molecular mediators of arterial inflammation: a role for microbial products? Am Heart J. 1999 Nov; 138(5 Pt 2):S450-2.
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Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest. 1999 Nov; 104(9):1191-7.
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Schönbeck U, Sukhova GK, Graber P, Coulter S, Libby P. Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions. Am J Pathol. 1999 Oct; 155(4):1281-91.
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Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol. 1999 Oct 1; 163(7):3753-7.
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Mach F, Sauty A, Iarossi AS, Sukhova GK, Neote K, Libby P, Luster AD. Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells. J Clin Invest. 1999 Oct; 104(8):1041-50.
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Aikawa M, Voglic SJ, Sugiyama S, Rabkin E, Taubman MB, Fallon JT, Libby P. Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. Circulation. 1999 Sep 14; 100(11):1215-22.
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Libby P, Ridker PM. Novel inflammatory markers of coronary risk: theory versus practice. Circulation. 1999 Sep 14; 100(11):1148-50.
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Kranzhöfer R, Maraganore JM, Baciu R, Libby P. Systemic thrombin inhibition by Hirulog does not alter medial smooth muscle cell proliferation and inflammatory activation after vascular injury in the rabbit. Cardiovasc Drugs Ther. 1999 Sep; 13(5):429-34.
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Melián A, Geng YJ, Sukhova GK, Libby P, Porcelli SA. CD1 expression in human atherosclerosis. A potential mechanism for T cell activation by foam cells. Am J Pathol. 1999 Sep; 155(3):775-86.
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McConnell MV, Aikawa M, Maier SE, Ganz P, Libby P, Lee RT. MRI of rabbit atherosclerosis in response to dietary cholesterol lowering. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):1956-9.
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Libby P, Mach F, Schönbeck U, Bourcier T, Aikawa M. Regulation of the thrombotic potential of atheroma. Thromb Haemost. 1999 Aug; 82(2):736-41.
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Lichtman AH, Clinton SK, Iiyama K, Connelly PW, Libby P, Cybulsky MI. Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):1938-44.
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Kranzhöfer R, Schmidt J, Pfeiffer CA, Hagl S, Libby P, Kübler W. Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1999 Jul; 19(7):1623-9.
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Rohde LE, Arroyo LH, Rifai N, Creager MA, Libby P, Ridker PM, Lee RT. Plasma concentrations of interleukin-6 and abdominal aortic diameter among subjects without aortic dilatation. Arterioscler Thromb Vasc Biol. 1999 Jul; 19(7):1695-9.
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Higuchi ML, Benvenuti LA, Demarchi LM, Libby P. Histological evidence of concomitant intramyocardial and epicardial vasculitis in necropsied heart allografts: a possible relationship with graft coronary arteriosclerosis. Transplantation. 1999 Jun 27; 67(12):1569-76.
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Marx N, Sukhova GK, Collins T, Libby P, Plutzky J. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation. 1999 Jun 22; 99(24):3125-31.
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Rohde LE, Ducharme A, Arroyo LH, Aikawa M, Sukhova GH, Lopez-Anaya A, McClure KF, Mitchell PG, Libby P, Lee RT. Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation. 1999 Jun 15; 99(23):3063-70.
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Sukhova GK, Schönbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation. 1999 May 18; 99(19):2503-9.
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Rajavashisth TB, Liao JK, Galis ZS, Tripathi S, Laufs U, Tripathi J, Chai NN, Xu XP, Jovinge S, Shah PK, Libby P. Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase. J Biol Chem. 1999 Apr 23; 274(17):11924-9.
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Marx N, Bourcier T, Sukhova GK, Libby P, Plutzky J. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler Thromb Vasc Biol. 1999 Mar; 19(3):546-51.
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Schönbeck U, Mach F, Sukhova GK, Atkinson E, Levesque E, Herman M, Graber P, Basset P, Libby P. Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo. J Exp Med. 1999 Mar 1; 189(5):843-53.
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Rohde LE, Aikawa M, Cheng GC, Sukhova G, Solomon SD, Libby P, Pfeffer J, Pfeffer MA, Lee RT. Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction. J Am Coll Cardiol. 1999 Mar; 33(3):835-42.
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Kol A, Bourcier T, Lichtman AH, Libby P. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J Clin Invest. 1999 Feb; 103(4):571-7.
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Newby AC, Libby P, van der Wal AC. Plaque instability--the real challenge for atherosclerosis research in the next decade? Cardiovasc Res. 1999 Feb; 41(2):321-2.
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Nagano H, Tilney NL, Stinn JL, Becker G, Hasegawa S, Libby P, Mitchell RN. Deficiencies of IL-4 or TNF-alpha receptor-1 do not diminish graft arteriosclerosis in cardiac allografts. Transplant Proc. 1999 Feb-Mar; 31(1-2):152.
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Libby P, Edelman E. Restenosis: involvement of growth factors and cytokines. Topol EJ, editor. Textbook of interventional cardiology, 3rd ed. 1999; 346-357.
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De Caterina R, Spiecker M, Solaini G, Basta G, Bosetti F, Libby P, Liao J. The inhibition of endothelial activation by unsaturated fatty acids. Lipids. 1999; 34 Suppl:S191-4.
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Mach F, Schönbeck U, Fabunmi RP, Murphy C, Atkinson E, Bonnefoy JY, Graber P, Libby P. T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism: implications for tubule formation. Am J Pathol. 1999 Jan; 154(1):229-38.
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Vatner SF, Berk BC, Hintze TH, Leinwand LA, Libby P, Marbán E, Schwartz K, Strauss HC, Yazaki Y . Eight years behind the masthead [editorial]. Circ Res. 1999; 84:1361-1364.
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Libby P. The increasing significance of the unstable atheroma. Adapted from: Lee R, Libby P. The increasing significance of the unstable atheroma. Atherosclerosis XI, Proceedings of the XIth International Atherosclerosis Symposium. Paris, October 1997. Newsletter of the International Atherosclerosis Society. 1999; 8:2-3.
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Libby P, Simon DI. Mechanisms of thrombosis and antiplatelet treatment [animated 6' video]. 1999.
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Henderson EL, Geng YJ, Sukhova GK, Whittemore AD, Knox J, Libby P. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation. 1999 Jan 5-12; 99(1):96-104.
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Libby P. Atherosclerosis [Harrison's 14 CD-ROM Version 1.2]. 1999.
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Libby P. Atherosclerotic vascular disease: new issues for the millennium. Plutzky J, Libby P, Nakamura H, editors. First US-Japanese dialogue on lipid disorders and coronary artery disease: new issues for the next millennium. International Congress and Symposium Series 238. 1999; 11-16.
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Libby P. Pathophysiology of acute coronary syndromes [CD]. 1999.
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Libby P. Russell Ross 1929-1999 [obituary]. Nature Med. 1999; 5:475.
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Libby P. Stabilization of the vulnerable atherosclerotic plaque [Interview with George A. Beller on audio tape]. 31(1):1. 1999.
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Aikawa M, Libby P. Potential mechanisms of atherosclerotic plaque stabilization by lipid lowering. Cardiovascular Risk Factors. 1999; 9:183-194.
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Libby P. The atherosclerotic process: The molecular basis of coronary artery disease [CD]. 1999.
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Nissen SE, Libby P. "Intra-vascular ultrasound and angiography: Exploring therapeutic options." [CD]
. 1999.
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Liao JK, Libby P. Nitric oxide and gene transcription. Rubanyi GM, editor. Pathophysiology and clinical applications of nitric oxide. 1999; 99-120.
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Newby AC, Libby P, van der Wal AC. Plaque instability—the real challenge for atherosclerosis in the next decade? [editorial}. Cardiovasc Res. 1999; 41:321-322.
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Libby P, Beller GA. Stabilization of the vulnerable atherosclerotic plaque [interview]. ACC Current Journal Review. 1999; 8:15-16.
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Kranzhöfer R, Schmidt J, Pfeiffer CAH, Hagl S, Libby P, Kübler W. Angiotensin induces inflammatory activation of human vascular smooth muscle cells: Mechanism of atherogenic action of the renin-angiotensin system. Arterioscler Thromb Vasc Biol. 1999; 19:1623-1629.
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Libby P. Plaque stabilization [CD]. 1999.
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Geng YJ, Azuma T, Tang JX, Hartwig JH, Muszynski M, Wu Q, Libby P, Kwiatkowski DJ. Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines. Eur J Cell Biol. 1998 Dec; 77(4):294-302.
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Marx N, Schönbeck U, Lazar MA, Libby P, Plutzky J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ Res. 1998 Nov 30; 83(11):1097-103.
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Aikawa M, Rabkin E, Voglic SJ, Shing H, Nagai R, Schoen FJ, Libby P. Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma. Circ Res. 1998 Nov 16; 83(10):1015-26.
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Stinn JL, Taylor MK, Becker G, Nagano H, Hasegawa S, Furakawa Y, Shimizu K, Libby P, Mitchell RN. Interferon-gamma-secreting T-cell populations in rejecting murine cardiac allografts: assessment by flow cytometry. Am J Pathol. 1998 Nov; 153(5):1383-92.
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Rohde LE, Lee RT, Rivero J, Jamacochian M, Arroyo LH, Briggs W, Rifai N, Libby P, Creager MA, Ridker PM. Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 1998 Nov; 18(11):1765-70.
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Ridker P, Libby P. Nontraditional coronary risk factors and vascular biology: the frontiers of preventive cardiology. J Investig Med. 1998 Oct; 46(8):338-50.
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Schönbeck U, Mach F, Libby P. Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing. J Immunol. 1998 Oct 1; 161(7):3340-6.
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Fabunmi RP, Sukhova GK, Sugiyama S, Libby P. Expression of tissue inhibitor of metalloproteinases-3 in human atheroma and regulation in lesion-associated cells: a potential protective mechanism in plaque stability. Circ Res. 1998 Aug 10; 83(3):270-8.
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Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell. 1998 Aug; 2(2):275-81.
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Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest. 1998 Aug 1; 102(3):576-83.
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Kol A, Sukhova GK, Lichtman AH, Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation. 1998 Jul 28; 98(4):300-7.
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Mach F, Schönbeck U, Sukhova GK, Atkinson E, Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature. 1998 Jul 9; 394(6689):200-3.
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Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. Am J Pathol. 1998 Jul; 153(1):17-23.
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Lafont A, Libby P. The smooth muscle cell: sinner or saint in restenosis and the acute coronary syndromes? J Am Coll Cardiol. 1998 Jul; 32(1):283-5.
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Hasegawa S, Becker G, Nagano H, Libby P, Mitchell RN. Pattern of graft- and host-specific MHC class II expression in long-term murine cardiac allografts: origin of inflammatory and vascular wall cells. Am J Pathol. 1998 Jul; 153(1):69-79.
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Kol A, Libby P. The mechanisms by which infectious agents may contribute to atherosclerosis and its clinical manifestations. Trends Cardiovasc Med. 1998 Jul; 8(5):191-9.
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Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE, Sukhova GK, Libby P. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation. 1998 Jun 23; 97(24):2433-44.
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De Caterina R, Bernini W, Carluccio MA, Liao JK, Libby P. Structural requirements for inhibition of cytokine-induced endothelial activation by unsaturated fatty acids. J Lipid Res. 1998 May; 39(5):1062-70.
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Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Becker G, Tilney NL, Mitchell RN. Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma. Am J Pathol. 1998 May; 152(5):1187-97.
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Mach F, Schönbeck U, Libby P. CD40 signaling in vascular cells: a key role in atherosclerosis? Atherosclerosis. 1998 Apr; 137 Suppl:S89-95.
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Yang JH, Briggs WH, Libby P, Lee RT. Small mechanical strains selectively suppress matrix metalloproteinase-1 expression by human vascular smooth muscle cells. J Biol Chem. 1998 Mar 13; 273(11):6550-5.
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Williams JK, Sukhova GK, Herrington DM, Libby P. Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys. J Am Coll Cardiol. 1998 Mar 1; 31(3):684-91.
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Libby P, Schoenbeck U, Mach F, Selwyn AP, Ganz P. Current concepts in cardiovascular pathology: the role of LDL cholesterol in plaque rupture and stabilization. Am J Med. 1998 Feb 23; 104(2A):14S-18S.
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Libby P. Gene therapy of restenosis: promise and perils. Circ Res. 1998 Feb 23; 82(3):404-6.
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Libby P, Schoenbeck U, Mach F, Selwyn AP, Ganz P. Current concepts in cardiovascular pathology: the role of LDL cholesterol in plaque rupture and stabilization. Gotto AM, editor. Challenges in clinical cardiology: a new era in lipid management. Am J Med. 1998; 104 [Suppl 2A]:14S-18S.
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Kinlay S, Selwyn AP, Libby P, Ganz P. Inflammation, the endothelium, and the acute coronary syndromes. J Cardiovasc Pharmacol. 1998; 32 Suppl 3:S62-6.
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Libby P, Ganz P, Schoen FJ, Lee RT. Vascular biology of the acute coronary syndromes. Topol EJ, editor. Acute coronary syndromes. 1998; 1-19.
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Libby P. "Biology of atherosclerosis" [audio tape]. American Diabetes Association, 58th Scientific Sessions. 1998.
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Libby P. The interface of atherosclerosis and thrombosis: basic mechanisms. Vasc Med. 1998; 3(3):225-9.
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Libby P. Biology of the vessel wall. Topol EJ, editor. Comprehensive cardiovascular medicine. 1998; 2893-2906.
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Lee RT, Libby P. The increasing significance of the unstable atheroma. Jacotot B, Mathé D, Fruchart J-C, editors. Atherosclerosis XI. 1998; 83-88.
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Libby P. Pathogenesis of atherosclerosis [animated 3'15" video]. 1998.
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Libby P, Aikawa M. New insights into plaque stabilisation by lipid lowering. Libby P, editor. Drugs. 1998; 56 [Suppl 1]:9-13.
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Bhattacharyya G, Libby P. Atherosclerosis. Lilly LJ, editor. Pathophysiology of heart disease: a collaborative project of medical students and faculty. 1998; 101-118.
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Aikawa M, Libby P. Stabilization of atherosclerotic plaques [in Japanese]. The Circulation Frontier. 1998; 3:20-26.
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Libby P. Inflammation and infection as risk factors for atherosclerosis [Interview with Carmichael DB on audio tape]. 30(7):4. 1998.
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Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPAR?: Differentiation-dependent peroxisomal proliferator-activated receptor ? (PPAR?) expression and reduction of MMP-9 activity through PPAR? activation in mononuclear phagocytes in vitro. Am J Pathol. 1998; 153:17-23.
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Libby P, Aikawa M. New insights into plaque stabilisation by lipid lowering. Drugs. 1998; 56 Suppl 1:9-13; discussion 33.
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Libby P. 1998;56 Suppl.1. Foreword to: Managing cholesterol in cardiovascular disease: use of cerivastatin in at-risk patients. Drugs. 1998; 56 [Suppl 1].
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Rajavashtisth T, Qiao J-H, Mishra N, Tripathi S, Tripathi J, Mishra N, Hua M, Wang X-P, Loussararian A, Clinton S, Libby P, Lusis A. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 1998; 101:2702-2710.
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Libby P, Hansson GK, Pober JS. Atherogenesis and inflammation. Chien KR, Breslow JL, Leiden JM, Rosenberg RD, Seidman C, editors. Molecular basis of heart disease. 1998; 349-366.
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Libby P, Sukhova G, Lee RT, Liao JK. Molecular biology of atherosclerosis. Int J Cardiol. 1997 Dec 31; 62 Suppl 2:S23-9.
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Libby P, Egan D, Skarlatos S. Roles of infectious agents in atherosclerosis and restenosis: an assessment of the evidence and need for future research. Circulation. 1997 Dec 2; 96(11):4095-103.
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Lee RT, Briggs WH, Cheng GC, Rossiter HB, Libby P, Kupper T. Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist. J Immunol. 1997 Nov 15; 159(10):5084-8.
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Lee RT, Libby P. The unstable atheroma. Arterioscler Thromb Vasc Biol. 1997 Oct; 17(10):1859-67.
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Geng YJ, Henderson LE, Levesque EB, Muszynski M, Libby P. Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997 Oct; 17(10):2200-8.
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Libby P, Tanaka H. The molecular bases of restenosis. Prog Cardiovasc Dis. 1997 Sep-Oct; 40(2):97-106.
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Schönbeck U, Mach F, Sukhova GK, Murphy C, Bonnefoy JY, Fabunmi RP, Libby P. Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture? Circ Res. 1997 Sep; 81(3):448-54.
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Libby P. Diabetes and vascular diseases. Therapie. 1997 Sep-Oct; 52(5):403-5.
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Schönbeck U, Mach F, Bonnefoy JY, Loppnow H, Flad HD, Libby P. Ligation of CD40 activates interleukin 1beta-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1beta. J Biol Chem. 1997 Aug 1; 272(31):19569-74.
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Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest. 1997 Aug 1; 100(3):550-7.
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Mach F, Schönbeck U, Bonnefoy JY, Pober JS, Libby P. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor. Circulation. 1997 Jul 15; 96(2):396-9.
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Bourcier T, Sukhova G, Libby P. The nuclear factor kappa-B signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis. J Biol Chem. 1997 Jun 20; 272(25):15817-24.
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Qiao JH, Tripathi J, Mishra NK, Cai Y, Tripathi S, Wang XP, Imes S, Fishbein MC, Clinton SK, Libby P, Lusis AJ, Rajavashisth TB. Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol. 1997 May; 150(5):1687-99.
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Libby P, Geng YJ, Sukhova GK, Simon DI, Lee RT. Molecular determinants of atherosclerotic plaque vulnerability. Ann N Y Acad Sci. 1997 Apr 15; 811:134-42; discussion 142-5.
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De Caterina R, Libby P. Towards an understanding of the molecular pathogenesis of acute coronary syndromes. Cardiologia. 1997 Apr; 42(4):359-74.
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Selwyn AP, Kinlay S, Creager M, Libby P, Ganz P. Cell dysfunction in atherosclerosis and the ischemic manifestations of coronary artery disease. Am J Cardiol. 1997 Mar 6; 79(5A):17-23.
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Mach F, Schönbeck U, Sukhova GK, Bourcier T, Bonnefoy JY, Pober JS, Libby P. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad Sci U S A. 1997 Mar 4; 94(5):1931-6.
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Galis ZS, Kranzhöfer R, Fenton JW, Libby P. Thrombin promotes activation of matrix metalloproteinase-2 produced by cultured vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997 Mar; 17(3):483-9.
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Selwyn AP, Kinlay S, Libby P, Ganz P. Atherogenic lipids, vascular dysfunction, and clinical signs of ischemic heart disease. Circulation. 1997 Jan 7; 95(1):5-7.
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Knox JB, Sukhova GK, Whittemore AD, Libby P. Evidence for altered balance between matrix metalloproteinases and their inhibitors in human aortic diseases. Circulation. 1997 Jan 7; 95(1):205-12.
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Libby P. Plaque rupture and triggering of cardiovascular disease onset: Role of mechanical factors and inflammation [Interview with Dennis M. Krickler on audio tape]. 29(1):3. 1997.
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Libby P. The vulnerable atherosclerotic plaque: Understanding, identification, and modification. IV: Structure of cellular components of vulnerable plaque. "Inflammatory cells." [CD]. 1997.
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Libby P, Kol A. Instabile, quindi pericolosa [Italian]. Sagramoso A, editor. Ricerce Roche, la cardiopatia ischemica, vol. 16. 1997; 51-52.
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Libby P. Atherosclerosis. Fauci S, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, editors. Harrison’s principles of internal medicine. 1997; 1345-1352.
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Libby P, Geng YJ, Sukhova GK, Simon DI, Lee RT. Molecular determinants of atherosclerotic plaque vulnerability. Numano F, Ross R, editors. Atherosclerosis IV: Recent advances in atherosclerosis research. The Fourth Saratoga International Conference on Atherosclerosis. Ann NY Acad Sci. 1997; 811:134-145.
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Libby P. Lipid management in clinical practice: Improving patient outcomes™ [CD]. 1997.
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Libby P. Restenosis: remodeling our thinking. Forward to: LaFont A, Topol EJ, editors. Arterial remodeling: a critical factor in restenosis. 1997; xxv-xxix.
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Cheng GC, Briggs WH, Gerson DS, Libby P, Grodzinsky AJ, Gray ML, Lee RT. Mechanical strain tightly controls fibroblast growth factor-2 release from cultured human vascular smooth muscle cells. Circ Res. 1997 Jan; 80(1):28-36.
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Libby P. The vulnerable atherosclerotic plaque: Understanding, identification, and modification. Session VI: Functional components of the vulnerable plaque. "Metalloproteinases and TIMP proteins." [CD]. 1997.
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Mach F, Schoenbeck U, Sukhova G, Bourcier T, Bonnefoy J, Pober JS, Libby P. Functional CD40 ligand is expressed on human vascular endothelial cells , smooth muscle cells and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad of Sci USA. 1997; 94:1931-1936.
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Allaire E, Libby P, Clowes A. Matrix metalloproteinases in injured artery. LaFont A, Topol EJ, editors. Arterial remodeling: a critical factor in restenosis. 1997; 305-338.
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Libby P and Ganz P. Restenosis revisited: new targets, new therapies [editorial]. N Eng J Med. 1997; 337:418-419.
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Libby P, Tanaka H, Kranzhöfer R, Sukhova G, Allaire E, Clowes AW, Ganz P. Inflammatory mechanisms of remodeling in injured arteries. LaFont A, Topol EJ, editors. Arterial remodeling: a critical factor in restenosis. 1997; 439-452.
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Libby P, Tanaka H. The molecular bases of restenosis. Topol EJ, editor. Prog Cardiovasc Dis. 1997; 40:97-106.
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Schoenbeck U, Mach F, Bonnefoy J-Y, Libby P. Ligation of CD40 activates interleukin-1?-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and yields secretion of active interleukin-1?. J Biol Chem. 1997; 272:19569-19574.
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Tanaka H, Sunamori M, Suzuki A, Sukhova G, Libby P. Endothelial activation potentiates neointimal lesion formation in the rabbit aorta after balloon injury. Numano F, Ross R, editors. Atherosclerosis IV: recent advances in atherosclerosis research. The Fourth Saratoga International Conference on Atherosclerosis. Ann NY Acad Sci. 1997; 811:448-458.
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Bourcier T, Sukhova G, Libby P. The nuclear factor kappa-B signaling pathway in dysregulation of vascular smooth muscle cells in vitro and in human arteriosclerosis. J Biol Chem. 1997; 25:15817-15824.
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Kinlay S, Selwyn AP, Delagrange D, Creager MA, Libby P, Ganz P. Biological mechanisms for the clinical success of lipid-lowering in coronary artery disease and the use of surrogate end-points. Curr Opin Lipidol. 1996 Dec; 7(6):389-97.
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Libby P. Atheroma: more than mush. Lancet. 1996 Nov; 348 Suppl 1:s4-7.
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Ganz P, Creager MA, Fang JC, McConnell MV, Lee RT, Libby P, Selwyn AP. Pathogenic mechanisms of atherosclerosis: effect of lipid lowering on the biology of atherosclerosis. Am J Med. 1996 Oct 8; 101(4A):4A10S-16S.
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Libby P, Geng YJ, Aikawa M, Schoenbeck U, Mach F, Clinton SK, Sukhova GK, Lee RT. Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol. 1996 Oct; 7(5):330-5.
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Kranzhöfer R, Clinton SK, Ishii K, Coughlin SR, Fenton JW, Libby P. Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circ Res. 1996 Aug; 79(2):286-94.
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Lee RT, Schoen FJ, Loree HM, Lark MW, Libby P. Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture. Arterioscler Thromb Vasc Biol. 1996 Aug; 16(8):1070-3.
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Vatner SF, Berk BC, Leinwand LA, Libby P, Schwartz K, Strauss HC. A second term for the editors. Status and goals for the review process. Circ Res. 1996 Jul; 79(1):1-3.
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Shin WS, Hong YH, Peng HB, De Caterina R, Libby P, Liao JK. Nitric oxide attenuates vascular smooth muscle cell activation by interferon-gamma. The role of constitutive NF-kappa B activity. J Biol Chem. 1996 May 10; 271(19):11317-24.
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Fuster V, Gotto AM, Libby P, Loscalzo J, McGill HC. 27th Bethesda Conference: matching the intensity of risk factor management with the hazard for coronary disease events. Task Force 1. Pathogenesis of coronary disease: the biologic role of risk factors. J Am Coll Cardiol. 1996 Apr; 27(5):964-76.
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De Caterina R, Libby P. Control of endothelial leukocyte adhesion molecules by fatty acids. Lipids. 1996 Mar; 31 Suppl:S57-63.
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McConnell MV, Ganz P, Lee RT, Selwyn AP, Libby P. Imaging atherosclerosis: lesion vs. lumen. Reiber JHC, van der Wall EE, editors. Cardiovascular imaging. 1996; 93-107.
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Libby P. "The role of mechanical factors and inflammation" [audio tape]. American Heart Association, Plenary Session V, 69th Scientific Sessions of the Joint AHA/ESC Symposium: Plaque Rupture and Triggering of Cardiovascular Disease Onset. 1996.
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Lee E, Vaughan DE, Parikh SH, Grodzinsky AJ, Libby P, Lark MW, Lee RT. Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells. Circ Res. 1996 Jan; 78(1):44-9.
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Lee RT, Libby P. Metalloproteinases and atherosclerotic plaque rupture. Schultheiss H-P, Schwimmbeck P, editors. The role of immune mechanisms in cardiovascular disease. 1996; 238-246.
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Libby P. Transplantation-associated arteriosclerosis: potential mechanisms. Tilney TB, Paul LC, editors. Transplantation biology: cellular and molecular aspects. 1996; 577-586.
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Libby P, Ross R
. Cytokines and growth regulatory molecules in atherosclerosis. Fuster V, Ross R, Topol E, editors. Atherosclerosis and coronary artery disease. 1996; 585-594.
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Libby P. Vascular cells produce and respond to cytokines. Hansson GK and Libby P, editors. Immune functions of the vessel wall. 1996; 45-64.
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Hansson GK, Libby P. The role of the lymphocyte. Fuster V, Ross R, Topol E, editors. Atherosclerosis and coronary artery disease. 1996; 557-568.
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Cheng GC, Libby P, Grodzinsky AJ, Lee RT. Induction of DNA synthesis by a single transient mechanical stimulus of human vascular smooth muscle cells. Role of fibroblast growth factor-2. Circulation. 1996 Jan 1; 93(1):99-105.
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Tanaka H, Sukhova G, Schwartz D, Libby P. Arterial smooth muscle cells proliferating following balloon injury express Tumor Necrosis Factor-? but not interleukin-1 or basic fibroblast growth factor. Arterioscler Thromb Vasc Biol. 1996; 16:12-18.
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Libby P. Pathogenesis of atherosclerosis: cellular interactions. Loscalzo J, Creager M, Dzau V, editors. Vascular medicine, 2nd ed. 1996; 297-306.
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Geng YJ, Wu Q, Muszynski M, Hansson GK, Libby P. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscler Thromb Vasc Biol. 1996 Jan; 16(1):19-27.
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Hansson GK, Libby P, editors. Immune functions of the vessel wall [monograph]. 1996.
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Newman KD, Dunn PF, Owens JW, Schulick AH, Virmani R, Sukhova G, Libby P, Dichek DA. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest. 1995 Dec; 96(6):2955-65.
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Lee E, Grodzinsky AJ, Libby P, Clinton SK, Lark MW, Lee RT. Human vascular smooth muscle cell-monocyte interactions and metalloproteinase secretion in culture. Arterioscler Thromb Vasc Biol. 1995 Dec; 15(12):2284-9.
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Hauptman PJ, Nakagawa T, Tanaka H, Libby P. Acute rejection: culprit or coincidence in the pathogenesis of cardiac graft vascular disease? J Heart Lung Transplant. 1995 Nov-Dec; 14(6 Pt 2):S173-80.
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Lipton BA, Parthasarathy S, Ord VA, Clinton SK, Libby P, Rosenfeld ME. Components of the protein fraction of oxidized low density lipoprotein stimulate interleukin-1 alpha production by rabbit arterial macrophage-derived foam cells. J Lipid Res. 1995 Oct; 36(10):2232-42.
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Tanaka H, Swanson SJ, Sukhova G, Schoen FJ, Libby P. Smooth muscle cells of the coronary arterial tunica media express tumor necrosis factor-alpha and proliferate during acute rejection of rabbit cardiac allografts. Am J Pathol. 1995 Sep; 147(3):617-26.
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De Caterina R, Tanaka H, Nakagawa T, Hauptman PJ, Libby P. The direct effect of injectable cyclosporine and its vehicle, cremophor, on endothelial vascular cell adhesion molecule-1 expression. Ricinoleic acid inhibits coronary artery endothelial activation. Transplantation. 1995 Aug 15; 60(3):270-5.
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Nakagawa T, Sukhova GK, Rabkin E, Winters GL, Schoen FJ, Libby P. Acute rejection accelerates graft coronary disease in transplanted rabbit hearts. Circulation. 1995 Aug 15; 92(4):987-93.
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Geng YJ, Libby P. Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme. Am J Pathol. 1995 Aug; 147(2):251-66.
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Peng HB, Rajavashisth TB, Libby P, Liao JK. Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells. J Biol Chem. 1995 Jul 14; 270(28):17050-5.
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De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MA, Shin WS, Liao JK. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest. 1995 Jul; 96(1):60-8.
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Galis ZS, Sukhova GK, Libby P. Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue. FASEB J. 1995 Jul; 9(10):974-80.
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Peng HB, Libby P, Liao JK. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem. 1995 Jun 9; 270(23):14214-9.
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Libby P. Molecular bases of the acute coronary syndromes. Circulation. 1995 Jun 1; 91(11):2844-50.
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De Caterina R, Cybulsky MA, Clinton SK, Gimbrone MA, Libby P. Omega-3 fatty acids and endothelial leukocyte adhesion molecules. Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar; 52(2-3):191-5.
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Tanaka H, Suzuki A, Schwartz D, Sukhova G, Libby P. Activation of smooth muscle and endothelial cells following balloon injury. Ann N Y Acad Sci. 1995 Jan 17; 748:526-9.
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Galis ZS, Sukhova GK, Kranzhöfer R, Clark S, Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci U S A. 1995 Jan 17; 92(2):402-6.
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Libby P, Galis ZS. Cytokines regulate genes involved in atherogenesis. Ann N Y Acad Sci. 1995 Jan 17; 748:158-68; discussion 168-70.
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Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Libby P. Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions. Ann N Y Acad Sci. 1995 Jan 17; 748:501-7.
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Libby P. Lesion versus lumen. Nat Med. 1995 Jan; 1(1):17-8.
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Tanaka H, Swanson SJ, Sukhova G, Schoen FJ, Libby P. Early proliferation of medial smooth muscle cells in coronary arteries of rabbit cardiac allografts during immunosuppression with cyclosporin A. Transplant Proc. 1995; 27:2062-2065.
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Libby P, Sukhova G, Lee RT, Galis ZS. Cytokines regulate vascular functions related to stability of the atherosclerotic plaque. J Cardiovasc Pharmacol. 1995; 25 Suppl 2:S9-12.
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Libby P. Future perspectives in atherosclerosis research: the promise of molecular biology. Koenig W, Hombach V, Bond MG, Kramsch DM, editors. Progression and regression of atherosclerosis. 1995; 476-477.
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Libby P, Lee RT. Role of activated macrophages and T lymphocytes in rupture of coronary plaques. Heart disease: a textbook of cardiovascular medicine. 1995; 1-9.
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De Caterina R, Libby P. n-3 fatty acids and atherogenesis: effects on leukocyte-endothelial interactions. Kristensen SD, Schmidt EB, De Caterina R, Endres S, editors. n-3 fatty acids: prevention and treatment in vascular disease. 1995; 24-44.
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Libby P, Sukhova G, Brogi E, Schoen FJ, Tanaka H. Schoen FJ, Tanaka H. Restenosis as an example of vascular hyperplastic disease: reassessment of potential mechanisms. Advances in vascular surgery, vol. 3. 1995; 279-290.
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Mitchell RN, Libby P. Cytokines as modulators of vascular disease. Orosz CG, editor. Transplantation vascular sclerosis. 1995; 165-174.
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Li H, Freeman MW, Libby P. Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines. J Clin Invest. 1995 Jan; 95(1):122-33.
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Sopko G, Libby P. Restenosis: pathophysiology and rational approaches to interventions: Theseus and Minotaur?. Vetrovec G, Carabello B, editors. Current diagnostic and therapeutic issues in invasive cardiology. 1995; 301-327.
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Libby P. The mechanistics of restenosis post angioplasty: a contratrian view. International Society for Applied Cardiovascular Biology (ISACB) Newsletter. 1995; 6-7.
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Libby P, Schoen FJ, Pober JS. The arteriosclerosis of cardiac transplantation. Haber E, editor. Molecular Cardiovascular Medicine. 1995; 311-324.
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Murray AG, Libby P, Pober JS. Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro. J Immunol. 1995 Jan 1; 154(1):151-61.
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Kranzhöfer R, Libby P. Interrelation between atherosclerosis and restenosis. Z Kardiol. 1995; 84 Suppl 4:125-8.
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Peng HB, Libby P, Liao JK. Induction and stabilization of I?B? by nitric oxide mediates inhibition of NF-?B. J Biol Chem. 1995; 270:14214-14219.
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De Caterina R, Libby P, Thannickal VJ, Peng HB, Rajavashisth TB, Gimbrone MA, Shin WS, Liao JK. Nitric oxide decreases cytokine-induced endothelial activation. J Clin Invest. 1995; 96:60-68.
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Libby P, Sukhova G, Kranzhöfer R, Tanaka H. Cellular activation in restenosis following angioplasty. Davignon J, Woodford FP, editors. Atherosclerosis X. 1995; 690-693.
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Libby P, Li H, Cybulsky MI. Adhesion molecules in recruitment of mononuclear cells to the arterial intima. Davignon J and Woodford FP, editors. Atherosclerosis X. 1995; 5282-585.
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Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994 Dec; 94(6):2493-503.
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De Caterina R, Cybulsky MI, Clinton SK, Gimbrone MA, Libby P. The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler Thromb. 1994 Nov; 14(11):1829-36.
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Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Unemori EN, Lark MW, Amento E, Libby P. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res. 1994 Jul; 75(1):181-9.
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Swanson SJ, Rosenzweig A, Seidman JG, Libby P. Diversity of T-cell antigen receptor V beta gene utilization in advanced human atheroma. Arterioscler Thromb. 1994 Jul; 14(7):1210-4.
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Libby P, Tanaka H. The pathogenesis of coronary arteriosclerosis ("chronic rejection") in transplanted hearts. Clin Transplant. 1994 Jun; 8(3 Pt 2):313-8.
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Tanaka H, Sukhova GK, Swanson SJ, Cybulsky MI, Schoen FJ, Libby P. Endothelial and smooth muscle cells express leukocyte adhesion molecules heterogeneously during acute rejection of rabbit cardiac allografts. Am J Pathol. 1994 May; 144(5):938-51.
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Tanaka H, Sukhova GK, Libby P. Interaction of the allogeneic state and hypercholesterolemia in arterial lesion formation in experimental cardiac allografts. Arterioscler Thromb. 1994 May; 14(5):734-45.
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Libby P . Restenosis: involvement of growth factors and cytokines. Topol EJ, editor. Textbook of interventional cardiology. 1994; 355-364.
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Libby P. "Cytokines as endogenous mediators of the vascular diseases" [audio tape]. American College of Cardiology 43rd Annual Scientific Congress: Role of Endogenous Mediators in the Development and Progression of Cardiovascular Diseases. ACC 94-641; part 1. 1994.
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Galis Z, Unemori E, Amento E, Lark M, Libby P. Cytokine-stimulated smooth muscle cells can produce a complement of metalloproteinases required for degradation of the vascular extracellular matrix. Circ Res. 1994; 75:181-189.
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Libby P. Advances in vascular biology: Implications for the clinical cardiologist [audio tape]. American College of Cardiology 43rd Annual Scientific Congress. ACC94-113; Part 2. 1994.
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Libby P. "Cytokines as endogenous mediators of the vascular diseases" [audio tape]. American College of Cardiology 43rd Annual Scientific Congress: Role of endogenous mediators in the development and progression of cardiovascular diseases. ACC94-651; Part 1. 1994.
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Li H, Cybulsky MI, Gimbrone MA, Libby P. Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma. Am J Pathol. 1993 Dec; 143(6):1551-9.
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Salomon RN, Friedman GB, Callow AD, Payne DD, Libby P. Cryopreserved aortic homografts contain viable smooth muscle cells capable of expressing transplantation antigens. J Thorac Cardiovasc Surg. 1993 Dec; 106(6):1173-80.
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Brogi E, Winkles JA, Underwood R, Clinton SK, Alberts GF, Libby P. Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages. J Clin Invest. 1993 Nov; 92(5):2408-18.
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Tanaka H, Sukhova GK, Swanson SJ, Clinton SK, Ganz P, Cybulsky MI, Libby P. Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury. Circulation. 1993 Oct; 88(4 Pt 1):1788-803.
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Libby P, Li H. Vascular cell adhesion molecule-1 and smooth muscle cell activation during atherogenesis. J Clin Invest. 1993 Aug; 92(2):538-9.
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Winkles JA, Alberts GF, Brogi E, Libby P. Endothelin-1 and endothelin receptor mRNA expression in normal and atherosclerotic human arteries. Biochem Biophys Res Commun. 1993 Mar 31; 191(3):1081-8.
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Li H, Cybulsky MI, Gimbrone MA, Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb. 1993 Feb; 13(2):197-204.
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Loppnow H, Rietschel E, Brade H, Schoenbeck U, Libby P, Wang M, Heine H, Feist W, Durrbaum-Landmann I, Ernst M, Brandt E, Grage-Griebenow E, Ulmer A, Campos-Portuguez S, Schade U, Kirikae T., Kusumoto S, Krauss J, Mayer H, and Flad, H. Lipid A precursor Ia (compound 406) and Rhodobacter capsulatus lipopolysaccharide: potent endotoxin antagonists in the human system in vitro. Levin J, Alving C, Munford R, Stutz P, editors. Bacterial endotoxin: recognition and effector mechanisms. 1993; 337-348.
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Libby P, Clinton SK. The role of macrophages in atherogenesis. Thompson G, editor. Curr Opin Lipidol. 1993; 4:355-363.
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Brandon EP, Kotik AN, Vachino G, Swack JA, Libby P, Janicka MW, Atkins MB, Mier JW. Cultured human endothelial cells express the 140 kD isoform of neural cell adhesion molecule (NCAM). Int J Immunopathol and Pharmacol. 1993; 6:77-84.
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Libby P, Schoen FJ. Vascular lesion formation. Didesheim P, Ratner B, Harker L, editors. Cardiovascular biomaterials and biocompatibility. NIH Handbook. Cardiovasc Pathol. 1993; 2:43S-52S.
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Schoen FJ, Libby P, Didesheim P. Future directions and therapeutic approaches. Didesheim P, Ratner B, Harker L, editors. Cardiovascular biomaterials and biocompatibility. NIH Handbook. Cardiovasc Pathol. 1993; 2:209S-216S.
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Libby P, Rabbani LE, Brogi E, Creager MA. The challenge of diabetic vascular disease. Bagdade JD, editor. Mosby yearbook of endocrinology. 1993; xix-xxv.
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Clinton SK, Libby P. Cytokines and growth factors in atherogenesis. Arch Pathol Lab Med. 1992 Dec; 116(12):1292-300.
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Libby P, Schwartz D, Brogi E, Tanaka H, Clinton SK. A cascade model for restenosis. A special case of atherosclerosis progression. Circulation. 1992 Dec; 86(6 Suppl):III47-52.
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Libby P. Do vascular wall cytokines promote atherogenesis? Hosp Pract (Off Ed). 1992 Oct 15; 27(10):51-8.
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Nadal-Ginard B, Leinwand LA, Libby P, Schwartz K, Strauss HC, Vatner SF. Cellular and molecular biology of the cardiovascular system. Circ Res. 1992 Jul; 71(1):1-2.
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Palmer H, Libby P. Interferon-beta. A potential autocrine regulator of human vascular smooth muscle cell growth. Lab Invest. 1992 Jun; 66(6):715-21.
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Libby P. Inducible gene expression in vascular wall cells and lesional leukocytes. J Vasc Surg. 1992 May; 15(5):916-7.
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Libby P, Swanson SJ, Tanaka H, Murray A, Schoen FJ, Pober JS. Immunopathology of coronary arteriosclerosis in transplanted hearts. J Heart Lung Transplant. 1992 May-Jun; 11(3 Pt 2):S5-6.
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Salomon RN, Underwood R, Doyle MV, Wang A, Libby P. Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma. Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):2814-8.
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Fleet JC, Clinton SK, Salomon RN, Loppnow H, Libby P. Atherogenic diets enhance endotoxin-stimulated interleukin-1 and tumor necrosis factor gene expression in rabbit aortae. J Nutr. 1992 Feb; 122(2):294-305.
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Clinton SK, Underwood R, Hayes L, Sherman ML, Kufe DW, Libby P. Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis. Am J Pathol. 1992 Feb; 140(2):301-16.
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Loppnow H, Libby P. Functional significance of human vascular smooth muscle cell-derived interleukin 1 in paracrine and autocrine regulation pathways. Exp Cell Res. 1992 Feb; 198(2):283-90.
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Libby P. Endothelium in the pathophysiology of coronary arteriopathy [Interview with James S. Forrester on audio tape]. 24(4):1. 1992.
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Libby P, Clinton SK. Cytokines as mediators of vascular pathology. Nouv Rev Fr Hematol. 1992; 34 Suppl:S47-53.
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Libby P. Do vascular wall cytokines promote atherogenesis?. Hosp Pract. 1992; 27:51-58.
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Libby P, Fleet JC, Salomon RN, Li H, Loppnow H, Clinton SK. Possible roles of cytokines in atherogenesis. Stein O, Eisenberg S, Stein Y, editors. Atherosclerosis. 1992; 339-350.
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Libby P. The biochemical basis of atherosclerosis: roles for cytokines. Rheinisch-Westfälische Akademie der Wissenchaften. 1992; 23-29.
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Libby P, Clinton SK. Cytokines as mediators of vascular pathology. J Exp Clin Hematol. 1992; S47-S53.
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Wang JM, Sica A, Peri G, Walter S, Padura IM, Libby P, Ceska M, Lindley I, Colotta F, Mantovani A. Expression of monocyte chemotactic protein and interleukin-8 by cytokine-activated human vascular smooth muscle cells. Arterioscler Thromb. 1991 Sep-Oct; 11(5):1166-74.
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Amento EP, Ehsani N, Palmer H, Libby P. Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arterioscler Thromb. 1991 Sep-Oct; 11(5):1223-30.
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Schoen FJ, Libby P. Cardiac transplant graft arteriosclerosis. Trends Cardiovasc Med. 1991 Jul-Aug; 1(5):216-23.
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Salomon RN, Hughes CC, Schoen FJ, Payne DD, Pober JS, Libby P. Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells. Am J Pathol. 1991 Apr; 138(4):791-8.
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Libby P, Pober JS, Swanson SJ, Mudge GH, Schoen FJ. Arteriosclerosis in transplanted hearts: too much and too soon. Can J Cardiol. 1991 Apr; 7(3):XI-XII.
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Clinton SK, Fleet JC, Loppnow H, Salomon RN, Clark BD, Cannon JG, Shaw AR, Dinarello CA, Libby P. Interleukin-1 gene expression in rabbit vascular tissue in vivo. Am J Pathol. 1991 Apr; 138(4):1005-14.
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Libby P, Hansson GK. Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. Lab Invest. 1991 Jan; 64(1):5-15.
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Pober JS, Hughes CCW, Savage COS, Schoen FJ, Libby P. Endothelial cell-lymphocyte interactions. Meltzer, MS and Mantovani A, editors. Cellular and cytokine networks in tissue immunity. 1991; 183-188.
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Libby P, Loppnow H, Fleet JC, Palmer H, Li HM, Warner SJC, Salomon RN, Clinton SK. Production of cytokines by vascular wall cells – an update and implications for atherogenesis. Gotlieb AI, Langille BL, Federoff S, editors. Atherosclerosis: cellular and molecular interactions in the artery wall. 1991; 161-169.
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Schoen FJ, Libby P. Cardiac transplant graft arteriosclerosis. Trends in Cardiovascular Medicine. 1991; 1:216-223.
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Libby P. Roles of vascular cells in inflammation and immunopathology. Catravas JD, Callow AD, Gillis CN, Ryan US, editors. Vascular endothelium: physiological basis of clinical problems. 1991; 87-95.
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Loppnow H, Libby P, Freudenberg M, Krauss JH, Weckesser J, Mayer H. Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS. Infect Immun. 1990 Nov; 58(11):3743-50.
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Loppnow H, Libby P. Proliferating or interleukin-1 activated human vascular smooth muscle cells secrete copious interleukin-6. J Clin Invest. 1990; 85:731-738.
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Libby P. Reactivity of the arterial wall: a remaining obstacle to the success of modern interventional therapy of cardiovascular diseases. Zilla P, Callow AD, editors. Applied cardiovascular biology. 1990; 147-153.
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Libby P. Vascular growth factors in heart disease [Interview with Adoph M. Hutter Jr. on audio tape]. 22(9):1. 1990.
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Libby P. Inflammatory and immune mechanisms in atherogenesis. Leaf A, Weber PC, editors. Atherosclerosis Reviews. 1990; 21:79-89.
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Libby P. Clinical importance of vascular growth factors in heart disease [audio tape]. ACC87-23, Side 2. 1990.
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Libby P, Friedman GB, Salomon RN. Cytokines as modulators of cell proliferation in fibrotic diseases. Am Rev Respir Dis. 1989 Oct; 140(4):1114-7.
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Mier JW, Brandon EP, Libby P, Janicka MW, Aronson FR. Activated endothelial cells resist lymphokine-activated killer cell-mediated injury. Possible role of induced cytokines in limiting capillary leak during IL-2 therapy. J Immunol. 1989 Oct 1; 143(7):2407-14.
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Loppnow H, Libby P. Adult human vascular endothelial cells express the IL6 gene differentially in response to LPS or IL1. Cell Immunol. 1989 Sep; 122(2):493-503.
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Libby P. The functions of blood vessel wall cells in atherogenesis and coronary artery disease. Arq Bras Cardiol. 1989 Aug; 53(2):71-4.
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Libby P, Salomon RN, Payne DD, Schoen FJ, Pober JS. Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis. Transplant Proc. 1989 Aug; 21(4):3677-84.
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Wilson JM, Birinyi LK, Salomon RN, Libby P, Callow AD, Mulligan RC. Implantation of vascular grafts lined with genetically modified endothelial cells. Science. 1989 Jun 16; 244(4910):1344-6.
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Warner SJ, Friedman GB, Libby P. Regulation of major histocompatibility gene expression in human vascular smooth muscle cells. Arteriosclerosis. 1989 May-Jun; 9(3):279-88.
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Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell. 1989 Apr 7; 57(1):167-75.
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Warner SJC, Friedman GB, Libby P. Immune interferon inhibits proliferation and induces 2’-5’-oligoadenylate synthetase gene expression in human vascular smooth muscle cells. J Clin Invest. 1989; 83:1174-1182.
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Birinyi LK, Warner SJC, Salomon RN, Callow AD, Libby P. Observations on smooth muscle cell cultures from hyperplastic lesions of prosthetic bypass grafts: production of platelet-derived growth factor-like mitogen and expression of a gene for a PDGF-receptor, a preliminary study. J Vasc Surg. 1989; 10:157-165.
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Warner SJ, Libby P. Human vascular smooth muscle cells. Target for and source of tumor necrosis factor. J Immunol. 1989 Jan 1; 142(1):100-9.
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Wilson JM, Birinyi LK, Salomon RN, Libby P, Callow AD, Mulligan RC. Genetically modified endothelial cells in the treatment of human diseases. Trans Assoc Am Physicians. 1989; 102:139-47.
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Loppnow H, Libby P. Comparative analysis of cytokine induction in human vascular endothelial and smooth muscle cells. Lymphokine Res. 1989; 8(3):293-9.
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Libby P. Regulation of smooth muscle proliferation in hyperplastic arterial lesions. J Vasc Surg. 1989; 10:564-566.
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Libby P, Warner SJC, Birinyi LK. Immune functions of vascular wall cells. Reichart B, editor. Recent advances in cardiovascular surgery. 1989; 250-269.
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Libby P, Loppnow H, Girard J. The rôles of endothelial cells in septic shock. Mercier JC, Beaufils F, editors. Chocs septiques en pédiatrie. 1989; 25-31.
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Chang BK, Libby PR, Bergeron RJ, Porter CW. Modulation of polyamine biosynthesis and transport by oncogene transfection. Biochem Biophys Res Commun. 1988 Nov 30; 157(1):264-70.
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Aronson FR, Libby P, Brandon EP, Janicka MW, Mier JW. IL-2 rapidly induces natural killer cell adhesion to human endothelial cells. A potential mechanism for endothelial injury. J Immunol. 1988 Jul 1; 141(1):158-63.
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Libby P, Warner SJ, Salomon RN, Birinyi LK. Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheroma. N Engl J Med. 1988 Jun 9; 318(23):1493-8.
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Libby P. Modification of vascular homeostasis by mediators of the inflammatory and immune responses. Schlegel N, Beaufils F, editors. Hemorragies et thromboses en pédiatrie. 1988; 157-163.
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Libby P, Warner SJC, Friedman GB. Interleukin-1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest. 1988; 88:487-498.
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Wyler DJ, Libby P, Prakash S, Prioli RP, Pereira ME. Elaboration by mammalian mesenchymal cells infected with Trypanosoma cruzi of a fibroblast-stimulating factor that may contribute to chagasic cardiomyopathy. Infect Immun. 1987 Dec; 55(12):3188-91.
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Warner SJ, Auger KR, Libby P. Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells. J Immunol. 1987 Sep 15; 139(6):1911-7.
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Warner SJ, Auger KR, Libby P. Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells. J Exp Med. 1987 May 1; 165(5):1316-31.
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Libby PR, Porter CW. Separation of two isozymes of polyamine oxidase from murine L1210 leukemia cells. Biochem Biophys Res Commun. 1987 Apr 14; 144(1):528-35.
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Wyler DJ, Prakash S, Libby P. Mesenchymal target cell specificity of egg granuloma-derived fibroblast growth factor in schistosomiasis. J Infect Dis. 1987 Apr; 155(4):728-36.
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Libby P. The active roles of cells of the blood vessel wall in health and disease. Mol Aspects Med. 1987; 9(6):499-567.
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Dinarello CA, Ikejima T, Warner SJC, Orencole SF, Lonnemann G, Cannon JG, Libby P. Interleukin-1 induces interleukin-1. I. Induction of circulating interleukin-1 in rabbits in vivo and in human mononuclear cells in vitro. J Immunol. 1987; 139:1902-1910.
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Libby P, Birinyi LK. The dynamic nature of vascular endothelial cell functions. Zilla P, Fasol RD, Deutch M, editors. Endothelialization of vascular grafts. 1987; 80-99.
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Libby P, Ordovas JM, Birinyi LK, Auger KR, Dinarello CA. Inducible interleukin-1 gene expression in human vascular smooth muscle cells. J Clin Invest. 1986 Dec; 78(6):1432-8.
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Libby P, Ordovas JM, Auger KR, Robbins AH, Birinyi LK, Dinarello CA. Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells. Am J Pathol. 1986 Aug; 124(2):179-85.
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Foxall TL, Auger KR, Callow AD, Libby P. Adult human endothelial cell coverage of small-caliber Dacron and polytetrafluoroethylene vascular prostheses in vitro. J Surg Res. 1986 Aug; 41(2):158-72.
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Shepard AD, Eldrup-Jorgensen J, Keough EM, Foxall TF, Ramberg K, Connolly RJ, Mackey WC, Gavris V, Auger KR, Libby P, et al. Endothelial cell seeding of small-caliber synthetic grafts in the baboon. Surgery. 1986 Mar; 99(3):318-26.
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Pober JS, Collins T, Gimbrone MA, Libby P, Reiss CS. Inducible expression of class II major histocompatibility complex antigens and the immunogenicity of vascular endothelium. Transplantation. 1986 Feb; 41(2):141-6.
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Libby P, Alroy J, Pereira ME. A neuraminidase from Trypanosoma cruzi removes sialic acid from the surface of mammalian myocardial and endothelial cells. J Clin Invest. 1986 Jan; 77(1):127-35.
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Libby P, Birinyi LK, Callow AD. Functions of endothelial cells related to seeding of vascular prostheses: the unanswered questions. Herring MB Glover J, editors. Endothelial seeding in vascular surgery. 1986; 17-35.
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Libby P, Raines EW, Cullinane PM, Ross R. Analysis of the mitogenic effect of fetuin preparations on arterial smooth muscle cells: the role of contaminant platelet-derived growth factor. J Cell Physiol. 1985 Dec; 125(3):357-66.
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Libby P, Miao P, Ordovas JM, Schaefer EJ. Lipoproteins increase growth of mitogen-stimulated arterial smooth muscle cells. J Cell Physiol. 1985 Jul; 124(1):1-8.
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Libby P, Wyler DJ, Janicka MW, Dinarello CA. Differential effects of human interleukin-1 on growth of human fibroblasts and vascular smooth muscle cells. Arteriosclerosis. 1985 Mar-Apr; 5(2):186-91.
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Ramberg K, Keough EM, Callow AD, Connolly R, Shepard A, Eldrup-Jorgensen J, Foxall T, Libby P, Kahn P. Indium-111 labeled platelet imaging of endothelial cell seeded small caliber synthetic grafts in the baboon. Journal of American Society Artificial Internal Organs. 1985; 8:95-98.
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Libby P, Russell RM. Hypertension in the elderly: nutritional considerations. Horan MJ et al., editor. NIH workshop on nutrition and hypertension. 1985; 285-301.
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Libby P, O'Brien KV. The role of protein breakdown in growth, quiescence, and starvation of vascular smooth muscle cells. J Cell Physiol. 1984 Mar; 118(3):317-23.
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Libby P. Long-term culture of contractile mammalian heart cells in a defined medium that limits non-muscle cell proliferation. J Mol Cell Cardiol. 1984; 16:803-811.
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Libby P, O’Brien KV. Culture of quiescent vascular smooth muscle cells in a defined serum-free medium. J Cell Physiol. 1983; 115:217-223.
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Libby P, Goldberg AL. The use of protease inhibitors to investigate pathways of protein breakdown in muscle. Schotland DL, editor. Disorders of the motor unit. 1982; 683-695.
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Libby P, Goldberg AL. Comparison of the control and pathways for degradation of the acetylcholine receptor and average protein in cultured muscle cells. J Cell Physiol. 1981 May; 107(2):185-94.
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Benacerraf BR, McLoud TC, Rhea JT, Tritschler V, Libby P. An assessment of the contribution of chest radiography in outpatients with acute chest complaints: a prospective study. Radiology. 1981 Feb; 138(2):293-9.
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Bursztajn S, Libby P. Morphological changes in cultured myotubes treated with agents that interfere with lysosomal function. Cell Tissue Res. 1981; 220(3):573-88.
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Goldberg AL, Tischler M, Libby P. Regulation of protein degradation in skeletal muscle. Biochem Soc Trans. 1980 Oct; 8(5):497.
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Libby PR. Rat liver nuclear N-acetyltransferases: separation of two enzymes with both histone and spermidine acetyltransferase activity. Arch Biochem Biophys. 1980 Aug; 203(1):384-9.
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Libby P, Goldberg AL. Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. Biochem J. 1980 Apr 15; 188(1):213-20.
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Libby P, Bursztajn S, Goldberg AL. Degradation of the acetylcholine receptor in cultured muscle cells: selective inhibitors and the fate of undegraded receptors. Cell. 1980 Feb; 19(2):481-91.
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Libby P, Goldberg AL. The control and mechanism of protein breakdown in striated muscle: studies with selective inhibitors. Wildenthal K, editor. Degradative processes in heart and skeletal muscle. 1980; 201-222.
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Libby P, Ingwall JS, Goldberg AL. Reduction of protein degradation and atrophy in cultured fetal mouse hearts by leupeptin. Am J Physiol. 1979 Jul; 237(1):E35-9.
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Libby P, Ingwall JS, Goldberg AL. Leupeptin decreases atrophy in cultured fetal mouse hearts. Am J Physiol. 1979; 237:E35-E39.
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Goldberg AL, DeMartino GN, Libby P. Influence of thyroid hormones and protease inhibitors on protein degradation in skeletal muscle. Aguayo AJ, Karpati G, editors. Current topics in nerve and muscle research. 1979; 53-69.
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Libby P, Goldberg AL. Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles. Science. 1978 Feb 3; 199(4328):534-6.
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Maroko PR, Hillis LD, Muller JE, Tavazzi L, Heyndrickx GR, Ray M, Chiariello M, Distante A, Askenazi J, Salerno J, Carpentier J, Reshetnaya NI, Radvany P, Libby P, Raabe DS, Chazov EI, Bobba P, Braunwald E. Favorable effects of hyaluronidase on electrocardiographic evidence of necrosis in patients with acute myocardial infarction. N Engl J Med. 1977 Apr 21; 296(16):898-903.
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Libby P, Maroko PR, Braunwald E. The effect of hypoglycemia on myocardial ischemic injury during acute experimental coronary artery occlusion. Circulation. 1975 Apr; 51(4):621-6.
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Maroko PR, Davidson DM, Libby P, Hagan AD, Braunwald E. The effect of hyaluronidase administration on myocardial ischemic injury in patients with acute myocardial infarction-a preliminary study. Ann Intern Med. 1975; 82:516-520.
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Braunwald E, Maroko PR, Libby P. Reduction of infarct size following coronary occlusion. Circ Res. 1974 Sep; 35 Suppl 3:192-201.
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Maroko PR, Libby P, Braunwald E. Effect of pharmacologic agents on the function of the ischemic heart. Am J Cardiol. 1973 Dec; 32(7):930-6.
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Libby PR. Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney. Biochem J. 1973 Aug; 134(4):907-12.
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Libby P, Maroko PR, Covell JW, Malloch CI, Ross J, Braunwald E. Effect of practolol on the extent of myocardial ischaemic injury after experimental coronary occlusion and its effects of ventricular function in the normal and ischaemic heart. Cardiovasc Res. 1973 Mar; 7(2):167-73.
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Libby P, Maroko PR, Bloor CM, Sobel BE, Braunwald E. Reduction of experimental myocardial infarct size by corticosteroid administration. J Clin Invest. 1973 Mar; 52(3):599-607.
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Sybers HD, Maroko PR, Ashraf M, Libby P, Braunwald E. The effect of glucose-insulin-potassium therapy on ultrastructure in acute experimental myocardial infarction. Am J Pathol. 1973; 70:401-420.
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Libby PR. Histone acetylation and hormone action. Early effects of oestradiol-17beta on histone acetylation in rat uterus. Biochem J. 1972 Dec; 130(3):663-9.
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Maroko PR, Libby P, Bloor CM, Sobel BE, Braunwald E. Reduction by hyaluronidase of myocardial necrosis following coronary artery occlusion. Circulation. 1972 Sep; 46(3):430-7.
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Maroko PR, Libby P, Sobel BE, Bloor CM, Sybers HD, Shell WE, Covell JW, Braunwald E. Effect of glucose-insulin-potassium infusion on myocardial infarction following experimental coronary artery occlusion. Circulation. 1972 Jun; 45(6):1160-75.
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Maroko PR, Bernstein EF, Libby P, DeLaria GA, Covell JW, Ross J, Braunwald E. Effects of intraaortic balloon counterpulsation on the severity of myocardial ischemic injury following acute coronary occlusion. Counterpulsation and myocardial injury. Circulation. 1972 Jun; 45(6):1150-9.
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Maroko PR, Libby P, Covell JW, Sobel BE, Ross J, Braunwald E. Precordial S-T segment elevation mapping: an atraumatic method for assessing alterations in the extent of myocardial ischemic injury. The effects of pharmacologic and hemodynamic interventions. Am J Cardiol. 1972 Feb; 29(2):223-30.
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Maroko PR, Libby P, Ginks WR, Bloor CM, Shell, WE Sobel BE, Ross J, Jr . Coronary artery reperfusion: I. Early effects on local myocardial function and the extent of myocardial necrosis. J Clin Invest. 1972; 51:2710-2717.
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Dao TL, Libby PR. Conjugation of steroid hormones by breast cancer tissue and selection of patients for adrenalectomy. Surgery. 1969 Jul; 66(1):162-6.
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Libby PR. Histone acetylation by cell-free preparations from rat uterus: in vitro stimulation by estradiol-17 beta. Biochem Biophys Res Commun. 1968 Apr 5; 31(1):59-65.
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