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Joseph J Locascio, PH.D.

TitleAssistant Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Warren Bldg, # 806
55 Fruit St
Boston MA 02114
Phone617/724-7192
Fax617/726-7718

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013 Oct 22; 81(17):1531-7.
    View in: PubMed
  2. Herskovits AZ, Locascio JJ, Peskind ER, Li G, Hyman BT. A Luminex Assay Detects Amyloid ß Oligomers in Alzheimer's Disease Cerebrospinal Fluid. PLoS One. 2013; 8(7):e67898.
    View in: PubMed
  3. Gomperts SN, Locascio JJ, Rentz D, Santarlasci A, Marquie M, Johnson KA, Growdon JH. Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia. Neurology. 2013 Jan 1; 80(1):85-91.
    View in: PubMed
  4. Wadsworth LP, Lorius N, Donovan NJ, Locascio JJ, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum. Dement Geriatr Cogn Disord. 2012; 34(2):96-111.
    View in: PubMed
  5. Gomperts SN, Locascio JJ, Marquie M, Santarlasci AL, Rentz DM, Maye J, Johnson KA, Growdon JH. Brain amyloid and cognition in Lewy body diseases. Mov Disord. 2012 Jul; 27(8):965-73.
    View in: PubMed
  6. Shirk SD, Mitchell MB, Shaughnessy LW, Sherman JC, Locascio JJ, Weintraub S, Atri A. A web-based normative calculator for the uniform data set (UDS) neuropsychological test battery. Alzheimers Res Ther. 2011; 3(6):32.
    View in: PubMed
  7. Locascio JJ, Atri A. An overview of longitudinal data analysis methods for neurological research. Dement Geriatr Cogn Dis Extra. 2011 Jan; 1(1):330-57.
    View in: PubMed
  8. Hu Y, Chopra V, Chopra R, Locascio JJ, Liao Z, Ding H, Zheng B, Matson WR, Ferrante RJ, Rosas HD, Hersch SM, Scherzer CR. Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17141-6.
    View in: PubMed
  9. O'Brien LM, Ziegler DA, Deutsch CK, Frazier JA, Herbert MR, Locascio JJ. Statistical adjustments for brain size in volumetric neuroimaging studies: some practical implications in methods. Psychiatry Res. 2011 Aug 30; 193(2):113-22.
    View in: PubMed
  10. Farabaugh AH, Locascio JJ, Yap L, Fava M, Bitran S, Sousa JL, Growdon JH. Assessing depression and factors possibly associated with depression during the course of Parkinson's disease. Ann Clin Psychiatry. 2011 Aug; 23(3):171-7.
    View in: PubMed
  11. Atri A, O'Brien JL, Sreenivasan A, Rastegar S, Salisbury S, DeLuca AN, O'Keefe KM, LaViolette PS, Rentz DM, Locascio JJ, Sperling RA. Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials. Arch Neurol. 2011 May; 68(5):599-606.
    View in: PubMed
  12. Marshall GA, Rentz DM, Frey MT, Locascio JJ, Johnson KA, Sperling RA. Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease. Alzheimers Dement. 2011 May; 7(3):300-8.
    View in: PubMed
  13. Mollenhauer B, Locascio JJ, Schulz-Schaeffer W, Sixel-Döring F, Trenkwalder C, Schlossmacher MG. a-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol. 2011 Mar; 10(3):230-40.
    View in: PubMed
  14. Putcha D, O'Keefe K, LaViolette P, O'Brien J, Greve D, Rentz DM, Locascio J, Atri A, Sperling R. Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults. Hum Brain Mapp. 2011 Dec; 32(12):2027-44.
    View in: PubMed
  15. Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR. PGC-1a, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med. 2010 Oct 6; 2(52):52ra73.
    View in: PubMed
  16. Serrano-Pozo A, Vega GL, Lütjohann D, Locascio JJ, Tennis MK, Deng A, Atri A, Hyman BT, Irizarry MC, Growdon JH. Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers. Alzheimer Dis Assoc Disord. 2010 Jul-Sep; 24(3):220-6.
    View in: PubMed
  17. Rentz DM, Locascio JJ, Becker JA, Moran EK, Eng E, Buckner RL, Sperling RA, Johnson KA. Cognition, reserve, and amyloid deposition in normal aging. Ann Neurol. 2010 Mar; 67(3):353-64.
    View in: PubMed
  18. Farabaugh A, Locascio JJ, Yap L, Growdon J, Fava M, Crawford C, Matthews J, McCutchen J, Buchin J, Pava J, Alpert JE. Cognitive-behavioral therapy for patients with Parkinson's disease and comorbid major depressive disorder. Psychosomatics. 2010 Mar-Apr; 51(2):124-9.
    View in: PubMed
  19. Farabaugh AH, Locascio JJ, Yap L, Weintraub D, McDonald WM, Agoston M, Alpert JE, Growdon J, Fava M. Pattern of depressive symptoms in Parkinson's disease. Psychosomatics. 2009 Sep-Oct; 50(5):448-54.
    View in: PubMed
  20. Freeman SH, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Locascio JJ, Lipsitz LA, Hyman BT. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease. J Neuropathol Exp Neurol. 2008 Dec; 67(12):1205-12.
    View in: PubMed
  21. Wonderlick JS, Ziegler DA, Hosseini-Varnamkhasti P, Locascio JJ, Bakkour A, van der Kouwe A, Triantafyllou C, Corkin S, Dickerson BC. Reliability of MRI-derived cortical and subcortical morphometric measures: effects of pulse sequence, voxel geometry, and parallel imaging. Neuroimage. 2009 Feb 15; 44(4):1324-33.
    View in: PubMed
  22. Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA. Imaging amyloid deposition in Lewy body diseases. Neurology. 2008 Sep 16; 71(12):903-10.
    View in: PubMed
  23. Atri A, Shaughnessy LW, Locascio JJ, Growdon JH. Long-term course and effectiveness of combination therapy in Alzheimer disease. Alzheimer Dis Assoc Disord. 2008 Jul-Sep; 22(3):209-21.
    View in: PubMed
  24. Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, Kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, Schlossmacher MG. Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp Neurol. 2008 Oct; 213(2):315-25.
    View in: PubMed
  25. Locascio JJ, Fukumoto H, Yap L, Bottiglieri T, Growdon JH, Hyman BT, Irizarry MC. Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. Arch Neurol. 2008 Jun; 65(6):776-85.
    View in: PubMed
  26. Mollenhauer B, Steinacker P, Bahn E, Bibl M, Brechlin P, Schlossmacher MG, Locascio JJ, Wiltfang J, Kretzschmar HA, Poser S, Trenkwalder C, Otto M. Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies. Neurodegener Dis. 2007; 4(5):366-75.
    View in: PubMed
  27. Scherzer CR, Eklund AC, Morse LJ, Liao Z, Locascio JJ, Fefer D, Schwarzschild MA, Schlossmacher MG, Hauser MA, Vance JM, Sudarsky LR, Standaert DG, Growdon JH, Jensen RV, Gullans SR. Molecular markers of early Parkinson's disease based on gene expression in blood. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):955-60.
    View in: PubMed
  28. Tokuda T, Salem SA, Allsop D, Mizuno T, Nakagawa M, Qureshi MM, Locascio JJ, Schlossmacher MG, El-Agnaf OM. Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease. Biochem Biophys Res Commun. 2006 Oct 13; 349(1):162-6.
    View in: PubMed
  29. Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology. 2005 Nov 8; 65(9):1402-8.
    View in: PubMed
  30. Atri A, Locascio JJ, Lin JM, Yap L, Dickerson BC, Grodstein F, Irizarry MC, Growdon JH, Greenberg SM. Prevalence and effects of lobar microhemorrhages in early-stage dementia. Neurodegener Dis. 2005; 2(6):305-12.
    View in: PubMed
  31. Skotko BG, Kensinger EA, Locascio JJ, Einstein G, Rubin DC, Tupler LA, Krendl A, Corkin S. Puzzling thoughts for H. M.: can new semantic information be anchored to old semantic memories? Neuropsychology. 2004 Oct; 18(4):756-69.
    View in: PubMed
  32. Fukumoto H, Tennis M, Locascio JJ, Hyman BT, Growdon JH, Irizarry MC. Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. Arch Neurol. 2003 Jul; 60(7):958-64.
    View in: PubMed
  33. Kensinger EA, Shearer DK, Locascio JJ, Growdon JH, Corkin S. Working memory in mild Alzheimer's disease and early Parkinson's disease. Neuropsychology. 2003 Apr; 17(2):230-9.
    View in: PubMed
  34. Locascio JJ, Corkin S, Growdon JH. Relation between clinical characteristics of Parkinson's disease and cognitive decline. J Clin Exp Neuropsychol. 2003 Feb; 25(1):94-109.
    View in: PubMed
  35. Cha JH, Farrell LA, Ahmed SF, Frey A, Hsiao-Ashe KK, Young AB, Penney JB, Locascio JJ, Hyman BT, Irizarry MC. Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein. Neurobiol Dis. 2001 Feb; 8(1):90-102.
    View in: PubMed
  36. Irizarry MC, Locascio JJ, Hyman BT. beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging. Am J Pathol. 2001 Jan; 158(1):173-7.
    View in: PubMed
  37. Binetti G, Locascio JJ, Corkin S, Vonsattel JP, Growdon JH. Differences between Pick disease and Alzheimer disease in clinical appearance and rate of cognitive decline. Arch Neurol. 2000 Feb; 57(2):225-32.
    View in: PubMed
  38. Rebeck GW, Cheung BS, Growdon WB, Deng A, Akuthota P, Locascio J, Greenberg SM, Hyman BT. Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease. Neurosci Lett. 1999 Sep 17; 272(3):155-8.
    View in: PubMed
  39. Postle BR, Locascio JJ, Corkin S, Growdon JH. The time course of spatial and object learning in Parkinson's disease. Neuropsychologia. 1997 Oct; 35(10):1413-22.
    View in: PubMed
  40. Locascio JJ, Jennings PJ, Moore CI, Corkin S. Time series analysis in the time domain and resampling methods for studies of functional magnetic resonance brain imaging. Hum Brain Mapp. 1997; 5(3):168-93.
    View in: PubMed
  41. Growdon JH, Locascio JJ, Corkin S, Gomez-Isla T, Hyman BT. Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology. 1996 Aug; 47(2):444-8.
    View in: PubMed
  42. Gomez-Isla T, West HL, Rebeck GW, Harr SD, Growdon JH, Locascio JJ, Perls TT, Lipsitz LA, Hyman BT. Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease. Ann Neurol. 1996 Jan; 39(1):62-70.
    View in: PubMed
  43. Locascio JJ, Growdon JH, Corkin S. Cognitive test performance in detecting, staging, and tracking Alzheimer's disease. Arch Neurol. 1995 Nov; 52(11):1087-99.
    View in: PubMed
  44. Harris DT, LoCascio J, Acevedo A, Olson GB, Bard J, Boyse EA. Analysis of the hairless mouse as a model for the effects of aging on the immune system. Immunol Lett. 1993 Apr; 36(1):19-26.
    View in: PubMed
  45. Locascio JJ, Lee J, Meltzer HY. Importance of adjusting for correlated concomitant variables in psychiatric research. Psychiatry Res. 1988 Mar; 23(3):311-27.
    View in: PubMed
  46. Arora RC, Locascio JJ, Meltzer HY. 3H-imipramine binding in blood platelets of schizophrenic patients. Psychiatry Res. 1986 Nov; 19(3):215-24.
    View in: PubMed
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