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Clark Kenneth Colton, PH.D.

TitleMember of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology
Address77 Massachusetts Ave 66-452
Cambridge MA 02139
Phone617/253-4585
Fax617/253-9695

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5022-7.
    View in: PubMed
  2. Johnson AS, O'Sullivan E, D'Aoust LN, Omer A, Bonner-Weir S, Fisher RJ, Weir GC, Colton CK. Quantitative assessment of islets of Langerhans encapsulated in alginate. Tissue Eng Part C Methods. 2011 Apr; 17(4):435-49.
    View in: PubMed
  3. Pisania A, Papas KK, Powers DE, Rappel MJ, Omer A, Bonner-Weir S, Weir GC, Colton CK. Enumeration of islets by nuclei counting and light microscopic analysis. Lab Invest. 2010 Nov; 90(11):1676-86.
    View in: PubMed
  4. Pisania A, Weir GC, O'Neil JJ, Omer A, Tchipashvili V, Lei J, Colton CK, Bonner-Weir S. Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest. 2010 Nov; 90(11):1661-75.
    View in: PubMed
  5. Powers DE, Millman JR, Bonner-Weir S, Rappel MJ, Colton CK. Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation. Biotechnol Prog. 2010 May-Jun; 26(3):805-18.
    View in: PubMed
  6. Papas KK, Colton CK, Qipo A, Wu H, Nelson RA, Hering BJ, Weir GC, Koulmanda M. Prediction of marginal mass required for successful islet transplantation. J Invest Surg. 2010 Feb; 23(1):28-34.
    View in: PubMed
  7. O'Sullivan ES, Johnson AS, Omer A, Hollister-Lock J, Bonner-Weir S, Colton CK, Weir GC. Rat islet cell aggregates are superior to islets for transplantation in microcapsules. Diabetologia. 2010 May; 53(5):937-45.
    View in: PubMed
  8. Millman JR, Tan JH, Colton CK. The effects of low oxygen on self-renewal and differentiation of embryonic stem cells. Curr Opin Organ Transplant. 2009 Dec; 14(6):694-700.
    View in: PubMed
  9. Papas KK, Suszynski TM, Colton CK. Islet assessment for transplantation. Curr Opin Organ Transplant. 2009 Dec; 14(6):674-82.
    View in: PubMed
  10. Horton RE, Millman JR, Colton CK, Auguste DT. Engineering microenvironments for embryonic stem cell differentiation to cardiomyocytes. Regen Med. 2009 Sep; 4(5):721-32.
    View in: PubMed
  11. Powers DE, Millman JR, Huang RB, Colton CK. Effects of oxygen on mouse embryonic stem cell growth, phenotype retention, and cellular energetics. Biotechnol Bioeng. 2008 Oct 1; 101(2):241-54.
    View in: PubMed
  12. Papas KK, Pisania A, Wu H, Weir GC, Colton CK. A stirred microchamber for oxygen consumption rate measurements with pancreatic islets. Biotechnol Bioeng. 2007 Dec 1; 98(5):1071-82.
    View in: PubMed
  13. Papas KK, Colton CK, Nelson RA, Rozak PR, Avgoustiniatos ES, Scott WE, Wildey GM, Pisania A, Weir GC, Hering BJ. Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant. 2007 Mar; 7(3):707-13.
    View in: PubMed
  14. Papas KK, Hering BJ, Guenther L, Gunther L, Rappel MJ, Colton CK, Avgoustiniatos ES. Pancreas oxygenation is limited during preservation with the two-layer method. Transplant Proc. 2005 Oct; 37(8):3501-4.
    View in: PubMed
  15. Papas KK, Avgoustiniatos ES, Tempelman LA, Weir GC, Colton CK, Pisania A, Rappel MJ, Friberg AS, Bauer AC, Hering BJ. High-density culture of human islets on top of silicone rubber membranes. Transplant Proc. 2005 Oct; 37(8):3412-4.
    View in: PubMed
  16. Omer A, Duvivier-Kali V, Fernandes J, Tchipashvili V, Colton CK, Weir GC. Long-term normoglycemia in rats receiving transplants with encapsulated islets. Transplantation. 2005 Jan 15; 79(1):52-8.
    View in: PubMed
  17. Karoor S, Molina J, Buchmann CR, Colton C, Logan JS, Henderson LW. Immunoaffinity removal of xenoreactive antibodies using modified dialysis or microfiltration membranes. Biotechnol Bioeng. 2003 Jan 20; 81(2):134-48.
    View in: PubMed
  18. Papas KK, Colton CK, Gounarides JS, Roos ES, Jarema MA, Shapiro MJ, Cheng LL, Cline GW, Shulman GI, Wu H, Bonner-Weir S, Weir GC. NMR spectroscopy in beta cell engineering and islet transplantation. Ann N Y Acad Sci. 2001 Nov; 944:96-119.
    View in: PubMed
  19. Trivedi N, Keegan M, Steil GM, Hollister-Lock J, Hasenkamp WM, Colton CK, Bonner-Weir S, Weir GC. Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses. Transplantation. 2001 Jan 27; 71(2):203-11.
    View in: PubMed
  20. Trivedi N, Steil GM, Colton CK, Bonner-Weir S, Weir GC. Improved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor. Cell Transplant. 2000 Jan-Feb; 9(1):115-24.
    View in: PubMed
  21. Wu H, Avgoustiniatos ES, Swette L, Bonner-Weir S, Weir GC, Colton CK. In situ electrochemical oxygen generation with an immunoisolation device. Ann N Y Acad Sci. 1999 Jun 18; 875:105-25.
    View in: PubMed
  22. Tatarkiewicz K, Hollister-Lock J, Quickel RR, Colton CK, Bonner-Weir S, Weir GC. Reversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets. Transplantation. 1999 Mar 15; 67(5):665-71.
    View in: PubMed
  23. Orsello CE, Lauffenburger DA, Colton CK. Characterization of cell detachment from hollow fiber affinity membranes. Biomed Sci Instrum. 1999; 35:315-20.
    View in: PubMed
  24. Suzuki K, Colton CK, Bonner-Weir S, Hollister J, Weir GC. Estimating number and volume of islets transplanted within a planar immunobarrier diffusion chamber. Methods Mol Med. 1999; 18:497-505.
    View in: PubMed
  25. Suzuki K, Bonner-Weir S, Trivedi N, Yoon KH, Hollister-Lock J, Colton CK, Weir GC. Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice. Transplantation. 1998 Jul 15; 66(1):21-8.
    View in: PubMed
  26. Suzuki K, Bonner-Weir S, Hollister-Lock J, Colton CK, Weir GC. Number and volume of islets transplanted in immunobarrier devices. Cell Transplant. 1998 Jan-Feb; 7(1):47-52.
    View in: PubMed
  27. Avgoustiniatos ES, Colton CK. Effect of external oxygen mass transfer resistances on viability of immunoisolated tissue. Ann N Y Acad Sci. 1997 Dec 31; 831:145-67.
    View in: PubMed
  28. Ferber S, Heimberg H, Brownlee M, Colton C. Surrogate beta cells. Diabetologia. 1997 Oct; 40 Suppl 3:B39-43.
    View in: PubMed
  29. Barakat AI, Karino T, Colton CK. Microcinematographic studies of flow patterns in the excised rabbit aorta and its major branches. Biorheology. 1997 May-Jun; 34(3):195-221.
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  30. Barakat AI, Marini RP, Colton CK. Measurement of flow rates through aortic branches in the anesthetized rabbit. Lab Anim Sci. 1997 Apr; 47(2):184-9.
    View in: PubMed
  31. Padera RF, Colton CK. Time course of membrane microarchitecture-driven neovascularization. Biomaterials. 1996 Feb; 17(3):277-84.
    View in: PubMed
  32. Pomianek MJ, Colton CK, Dinarello CA, Miller LC. Synthesis of tumor necrosis factor alpha and interleukin-1 receptor antagonist, but not interleukin-1, by human mononuclear cells is enhanced by exposure of whole blood to shear stress. ASAIO J. 1996 Jan-Feb; 42(1):52-9.
    View in: PubMed
  33. Charcosset C, Su Z, Karoor S, Daun G, Colton CK. Protein A immunoaffinity hollow fiber membranes for immunoglobulin G purification: experimental characterization. Biotechnol Bioeng. 1995 Nov 20; 48(4):415-27.
    View in: PubMed
  34. Colton CK. Implantable biohybrid artificial organs. Cell Transplant. 1995 Jul-Aug; 4(4):415-36.
    View in: PubMed
  35. McKee M, Jupiter J, Toh CL, Wilson L, Colton C, Karras KK. Reconstruction after malunion and nonunion of intra-articular fractures of the distal humerus. Methods and results in 13 adults. J Bone Joint Surg Br. 1994 Jul; 76(4):614-21.
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  36. Colton CK, Ward RA, Shaldon S. Scientific basis for assessment of biocompatibility in extracorporeal blood treatment. Nephrol Dial Transplant. 1994; 9 Suppl 2:11-7.
    View in: PubMed
  37. Dionne KE, Colton CK, Yarmush ML. Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans. Diabetes. 1993 Jan; 42(1):12-21.
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  38. Barakat AI, Uhthoff PA, Colton CK. Topographical mapping of sites of enhanced HRP permeability in the normal rabbit aorta. J Biomech Eng. 1992 Aug; 114(3):283-92.
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  39. Murphy RM, Yarmush ML, Colton CK. Determining molecular weight distributions of antigen-antibody complexes by quasi-elastic light scattering. Biopolymers. 1991 Oct; 31(11):1289-95.
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  40. Dionne KE, Colton CK, Yarmush ML. A microperifusion system with environmental control for studying insulin secretion by pancreatic tissue. Biotechnol Prog. 1991 Jul-Aug; 7(4):359-68.
    View in: PubMed
  41. Colton CK, Avgoustiniatos ES. Bioengineering in development of the hybrid artificial pancreas. J Biomech Eng. 1991 May; 113(2):152-70.
    View in: PubMed
  42. Antonsen KP, Colton CK, Yarmush ML. Elution conditions and degradation mechanisms in long-term immunoadsorbent use. Biotechnol Prog. 1991 Mar-Apr; 7(2):159-72.
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  43. Murphy RM, Chamberlin RA, Schurtenberger P, Colton CK, Yarmush ML. Size and structure of antigen-antibody complexes: thermodynamic parameters. Biochemistry. 1990 Dec 11; 29(49):10889-99.
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  44. Tompkins RG, Yarmush ML, Schnitzer JJ, Colton CK, Smith KA, Stemerman MB. Low-density lipoprotein transport in blood vessel walls of squirrel monkeys. Am J Physiol. 1989 Aug; 257(2 Pt 2):H452-64.
    View in: PubMed
  45. Dionne KE, Colton CK, Yarmush ML. Effect of oxygen on isolated pancreatic tissue. ASAIO Trans. 1989 Jul-Sep; 35(3):739-41.
    View in: PubMed
  46. Murphy RM, Colton CK, Yarmush ML. Staphylococcal protein A adsorption in neoplastic disease: analysis of physicochemical aspects. Mol Biother. 1989; 1(4):186-207.
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  47. Tompkins RG, Schnitzer JJ, Yarmush ML, Colton CK, Smith KA. Measurement of 125I-low density lipoprotein uptake in selected tissues of the squirrel monkey by quantitative autoradiography. Am J Pathol. 1988 Sep; 132(3):526-42.
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  48. Murphy RM, Slayter H, Schurtenberger P, Chamberlin RA, Colton CK, Yarmush ML. Size and structure of antigen-antibody complexes. Electron microscopy and light scattering studies. Biophys J. 1988 Jul; 54(1):45-56.
    View in: PubMed
  49. Colton CK. The interleukin hypothesis: a quantitative assessment. Kidney Int Suppl. 1988 Mar; 24:S27-9.
    View in: PubMed
  50. Yarmush DM, Murphy RM, Colton CK, Fisch M, Yarmush ML. Quasi-elastic light scattering of antigen-antibody complexes. Mol Immunol. 1988 Jan; 25(1):17-32.
    View in: PubMed
  51. Morel GA, Yarmush DM, Colton CK, Benjamin DC, Yarmush ML. Monoclonal antibodies to bovine serum albumin: affinity and specificity determinations. Mol Immunol. 1988 Jan; 25(1):7-15.
    View in: PubMed
  52. Schnitzer JJ, Morrel EM, Colton CK, Smith KA, Stemerman MB. Absolute quantitative autoradiography of low concentrations of [125I]-labeled proteins in arterial tissue. J Histochem Cytochem. 1987 Dec; 35(12):1439-50.
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  53. Ofsthun NJ, Colton CK. Visual evidence of concentration polarization in cross-flow membrane plasmapheresis. ASAIO Trans. 1987 Jul-Sep; 33(3):510-7.
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  54. Colton CK. Analysis of membrane processes for blood purification. Blood Purif. 1987; 5(4):202-51.
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  55. Morrel EM, Holland JA, Pritchard KA, Colton CK, Stemerman MB. Endothelial cell perturbation and low-density lipoprotein. Quantitative autoradiography. Ann N Y Acad Sci. 1987; 516:412-7.
    View in: PubMed
  56. Colton CK. Quantitation of membrane biocompatibility. Contrib Nephrol. 1987; 59:110-25.
    View in: PubMed
  57. Stemerman MB, Morrel EM, Burke KR, Colton CK, Smith KA, Lees RS. Local variation in arterial wall permeability to low density lipoprotein in normal rabbit aorta. Arteriosclerosis. 1986 Jan-Feb; 6(1):64-9.
    View in: PubMed
  58. Ramirez CA, Colton CK, Smith KA, Stemerman MB, Lees RS. Transport of 125I-albumin across normal and deendothelialized rabbit thoracic aorta in vivo. Arteriosclerosis. 1984 May-Jun; 4(3):283-91.
    View in: PubMed
  59. Stemerman MB, Colton C, Morell E. Perturbations of the endothelium. Prog Hemost Thromb. 1984; 7:289-324.
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  60. Schneiderman G, Pritchard WF, Ramírez CA, Colton CK, Smith KA, Stemerman MB. Rabbit aortic medial thickness under relaxed and specified simulated in vivo conditions. Am J Physiol. 1983 Oct; 245(4):H623-7.
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  61. Chisolm GM, Bohrer MP, Colton CK, Smith KA, Lees RS. Transmural [125I]albumin concentration in the rabbit aorta during acute hypoxia. Atherosclerosis. 1983 Feb; 46(2):195-202.
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  62. Feig LA, Peppas NA, Colton CK, Smith KA, Lees RS. The effect of angiotensin II on in vivo albumin transport in normal rabbit aortic tissue. Atherosclerosis. 1982 Sep; 44(3):307-18.
    View in: PubMed
  63. Ramírez CA, Stemerman MB, Isaacson KA, Colton CK, Smith KA, Lees RS. Morphological and morphometric characterization of platelet adhesion to the exposed subendothelium of the rabbit thoracic aorta in vivo. Microvasc Res. 1981 May; 21(3):320-31.
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  64. Vilker VL, Dileo AJ, Colton CK, Smith KA. Device for the measurement of small liquid flow rates. Rev Sci Instrum. 1979 May; 50(5):640.
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  65. Guyton JR, Soeldner JS, Giner J, Colton CK, Morris RS. The development of an implantable electrochemical glucose sensor: response to glucose in bovine serum ultrafiltrate. Horm Metab Res Suppl. 1979; (8):24-6.
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  66. Bratzler RL, Chisolm GM, Colton CK, Smith KA, Lees RS. The distribution of labeled low-density lipoproteins across the rabbit thoracic aorta in vivo. Atherosclerosis. 1977 Nov; 28(3):289-307.
    View in: PubMed
  67. Chick WL, Perna JJ, Lauris V, Low D, Galletti PM, Panol G, Whittemore AD, Like AA, Colton CK, Lysaght MJ. Artificial pancreas using living beta cells:. effects on glucose homeostasis in diabetic rats. Science. 1977 Aug 19; 197(4305):780-2.
    View in: PubMed
  68. Bratzler RL, Chisolm GM, Colton CK, Smith KA, Zilversmit DB, Lees RS. The distribution of labeled albumin across the rabbit thoracic aorta in vivo. Circ Res. 1977 Feb; 40(2):182-90.
    View in: PubMed
  69. Bratzler RL, Colton CK, Smith KA. Theoretical models for transport of low-density lipoproteins in the arterial wall. Adv Exp Med Biol. 1977; 82:943-51.
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  70. Whittemore AD, Chick WL, Galletti PM, Like AA, Colton CK, Lysaght MJ, Richardson PD. Effects of the hybrid artificial pancreas in diabetic rats. Trans Am Soc Artif Intern Organs. 1977; 23:336-41.
    View in: PubMed
  71. Stroeve P, Smith KA, Colton CK. Facilitated diffusion of oxygen in red blood cell suspensions. Adv Exp Med Biol. 1976; 75:191-8.
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  72. Stroeve P, Smith KA, Colton CK. Facilitated transport of oxygen in blood in terms of the Adair mechanism and the effect of 2,3-Diphosphoglycerate. Bibl Anat. 1975; 13:173-4.
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  73. Meldon JH, Smith KA, Colton CK. Analysis of 2,3 diphosphoglycerate-mediated, hemoglobin-facilitated oxygen transport in terms of the Adair reaction mechanism. Adv Exp Med Biol. 1973; 37A:199-205.
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  74. Colton CK, Smith KA, Merrill EW, Farrell PC. Permeability studies with cellulosic membranes. J Biomed Mater Res. 1971 Sep; 5(5):459-88.
    View in: PubMed
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