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Monique M. Breteler, Ph.D., M.D.

TitleAdjunct Professor of Epidemiology
InstitutionHarvard School of Public Health
DepartmentEpidemiology
AddressHarvard School of Public Health
Kresge Bldg 9 Flr, Epidemiology
677 Huntington Ave
Boston MA 02115

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge Rv, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013 Aug; 12(8):822-38.
    View in: PubMed
  2. van Velsen EF, Vernooij MW, Vrooman HA, van der Lugt A, Breteler MM, Hofman A, Niessen WJ, Ikram MA. Brain cortical thickness in the general elderly population: The Rotterdam Scan Study. Neurosci Lett. 2013 Aug 29; 550:189-94.
    View in: PubMed
  3. Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Schagen SB. Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia. Crit Rev Oncol Hematol. 2013 Oct; 88(1):87-101.
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  4. Blom JW, de Ruijter W, Witteman JC, Assendelft WJ, Breteler MM, Hofman A, Gussekloo J. Erratum to: Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study. Age (Dordr). 2013 Apr; 35(2):439-40.
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  5. Verhaaren BF, Vernooij MW, Dehghan A, Vrooman HA, de Boer R, Hofman A, Witteman JC, Niessen WJ, Breteler MM, van der Lugt A, Ikram MA. The relation of uric Acid to brain atrophy and cognition: the rotterdam scan study. Neuroepidemiology. 2013; 41(1):29-34.
    View in: PubMed
  6. Devore EE, Feskens E, Ikram MA, den Heijer T, Vernooij M, van der Lijn F, Hofman A, Niessen WJ, Breteler MM. Total antioxidant capacity of the diet and major neurologic outcomes in older adults. Neurology. 2013 Mar 5; 80(10):904-10.
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  7. Medici M, Ikram MA, van der Lijn F, Heijer Td, Vernooij MW, Hofman A, Niessen WJ, Visser TJ, Breteler MM, Peeters RP. The Thyroid Hormone Receptor Alpha Locus and White Matter Lesions: A Role for the Clock Gene REV-ERBa. Thyroid. 2012 Nov; 22(11):1181-6.
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  8. Wieberdink RG, Koudstaal PJ, Hofman A, Witteman JC, Breteler MM, Arfan Ikram M. Insulin resistance and the risk of stroke and stroke subtypes in the nondiabetic elderly. Am J Epidemiol. 2012 Oct 15; 176(8):699-707.
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  9. Bullock JM, Medway C, Cortina-Borja M, Turton JC, Prince JA, Ibrahim-Verbaas CA, Schuur M, Breteler MM, van Duijn CM, Kehoe PG, Barber R, Coto E, Alvarez V, Deloukas P, Hammond N, Combarros O, Mateo I, Warden DR, Lehmann MG, Belbin O, Brown K, Wilcock GK, Heun R, Kölsch H, Smith AD, Lehmann DJ, Morgan K. Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease. Neurobiol Aging. 2013 Apr; 34(4):1309.e1-7.
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  10. Verlinden VJ, van der Geest JN, Hoogendam YY, Hofman A, Breteler MM, Ikram MA. Gait patterns in a community-dwelling population aged 50 years and older. Gait Posture. 2013 Apr; 37(4):500-5.
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  11. den Heijer T, der Lijn Fv, Vernooij MW, de Groot M, Koudstaal PJ, der Lugt Av, Krestin GP, Hofman A, Niessen WJ, Breteler MM. Structural and diffusion MRI measures of the hippocampus and memory performance. Neuroimage. 2012 Dec; 63(4):1782-9.
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  12. Poels MM, Steyerberg EW, Wieberdink RG, Hofman A, Koudstaal PJ, Ikram MA, Breteler MM. Assessment of cerebral small vessel disease predicts individual stroke risk. J Neurol Neurosurg Psychiatry. 2012 Dec; 83(12):1174-9.
    View in: PubMed
  13. Poels MM, Zaccai K, Verwoert GC, Vernooij MW, Hofman A, van der Lugt A, Witteman JC, Breteler MM, Mattace-Raso FU, Ikram MA. Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study. Stroke. 2012 Oct; 43(10):2637-42.
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  14. Ibrahim-Verbaas CA, Zorkoltseva IV, Amin N, Schuur M, Coppus AM, Isaacs A, Aulchenko YS, Breteler MM, Ikram MA, Axenovich TI, Verbeek MM, van Swieten JC, Oostra BA, van Duijn CM. Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aß-40 levels to presenilin 2. Hum Genet. 2012 Dec; 131(12):1869-76.
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  15. Schrijvers EM, Buitendijk GH, Ikram MK, Koudstaal PJ, Hofman A, Vingerling JR, Breteler MM. Retinopathy and risk of dementia: the Rotterdam Study. Neurology. 2012 Jul 24; 79(4):365-70.
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  16. Verhaaren BF, Vernooij MW, Koudstaal PJ, Uitterlinden AG, van Duijn CM, Hofman A, Breteler MM, Ikram MA. Alzheimer's disease genes and cognition in the nondemented general population. Biol Psychiatry. 2013 Mar 1; 73(5):429-34.
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  17. Schrijvers EM, Verhaaren BF, Koudstaal PJ, Hofman A, Ikram MA, Breteler MM. Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study. Neurology. 2012 May 8; 78(19):1456-63.
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  18. Devore EE, Kang JH, Breteler MM, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol. 2012 Jul; 72(1):135-43.
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  19. Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR, Rivadeneira F, Uitterlinden AG, Knopman DS, Hartikainen AL, Pennell CE, Thiering E, Steegers EA, Hakonarson H, Heinrich J, Palmer LJ, Jarvelin MR, McCarthy MI, Grant SF, St Pourcain B, Timpson NJ, Smith GD, Sovio U, Nalls MA, Au R, Hofman A, Gudnason H, van der Lugt A, Harris TB, Meeks WM, Vernooij MW, van Buchem MA, Catellier D, Jaddoe VW, Gudnason V, Windham BG, Wolf PA, van Duijn CM, Mosley TH, Schmidt H, Launer LJ, Breteler MM, DeCarli C. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet. 2012 May; 44(5):539-44.
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  20. Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Møller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bønnelykke K, Buxton JL, Charoen P, Chawes BL, Eriksson J, Evans DM, Hofman A, Kemp JP, Kim CE, Klopp N, Lahti J, Lye SJ, McMahon G, Mentch FD, Müller-Nurasyid M, O'Reilly PF, Prokopenko I, Rivadeneira F, Steegers EA, Sunyer J, Tiesler C, Yaghootkar H, Breteler MM, Decarli C, Breteler MM, Debette S, Fornage M, Gudnason V, Launer LJ, van der Lugt A, Mosley TH, Seshadri S, Smith AV, Vernooij MW, Blakemore AI, Chiavacci RM, Feenstra B, Fernandez-Banet J, Grant SF, Hartikainen AL, van der Heijden AJ, Iñiguez C, Lathrop M, McArdle WL, Mølgaard A, Newnham JP, Palmer LJ, Palotie A, Pouta A, Ring SM, Sovio U, Standl M, Uitterlinden AG, Wichmann HE, Vissing NH, DeCarli C, van Duijn CM, McCarthy MI, Koppelman GH, Estivill X, Hattersley AT, Melbye M, Bisgaard H, Pennell CE, Widen E, Hakonarson H, Smith GD, Heinrich J, Jarvelin MR, Jaddoe VW. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet. 2012 May; 44(5):532-8.
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  21. Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, DeStefano AL, Lambert JC, Jack CR, Struchalin M, Stankovich J, Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH, Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RF, Beiser A, Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK, Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM, Nalls MA, Uitterlinden AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V, Breteler MM, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA, van der Lugt A, Gudnason V, Longstreth WT, Brown MA, Bennett DA, van Duijn CM, Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet. 2012 May; 44(5):545-51.
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  22. Ray K, Wainwright NW, Visser L, Witteman J, Breteler M, Ambegaonkar B, Hofman A, Stricker B, Wareham N, Khaw KT, Sandhu M. Changes in HDL cholesterol and cardiovascular outcomes after lipid modification therapy. Heart. 2012 May; 98(10):780-5.
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  23. Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, Alvarez V, Sims R, Gerrish A, Chapman J, Deniz-Naranjo C, Solfrizzi V, Sorbi S, Arosio B, Spalletta G, Siciliano G, Epelbaum J, Hannequin D, Dartigues JF, Tzourio C, Berr C, Schrijvers EM, Rogers R, Tosto G, Pasquier F, Bettens K, Van Cauwenberghe C, Fratiglioni L, Graff C, Delepine M, Ferri R, Reynolds CA, Lannfelt L, Ingelsson M, Prince JA, Chillotti C, Pilotto A, Seripa D, Boland A, Mancuso M, Bossù P, Annoni G, Nacmias B, Bosco P, Panza F, Sanchez-Garcia F, Del Zompo M, Coto E, Owen M, O'Donovan M, Valdivieso F, Caffara P, Scarpini E, Combarros O, Buée L, Campion D, Soininen H, Breteler M, Riemenschneider M, Van Broeckhoven C, Alpérovitch A, Lathrop M, Trégouët DA, Williams J, Amouyel P. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. Mol Psychiatry. 2013 Apr; 18(4):461-70.
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  24. Wieberdink RG, Ikram MA, Hofman A, Koudstaal PJ, Breteler MM. Trends in stroke incidence rates and stroke risk factors in Rotterdam, the Netherlands from 1990 to 2008. Eur J Epidemiol. 2012 Apr; 27(4):287-95.
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  25. Hoogendam YY, van der Geest JN, van der Lijn F, van der Lugt A, Niessen WJ, Krestin GP, Hofman A, Vernooij MW, Breteler MM, Ikram MA. Determinants of cerebellar and cerebral volume in the general elderly population. Neurobiol Aging. 2012 Dec; 33(12):2774-81.
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  26. Poels MM, Ikram MA, van der Lugt A, Hofman A, Niessen WJ, Krestin GP, Breteler MM, Vernooij MW. Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology. 2012 Jan 31; 78(5):326-33.
    View in: PubMed
  27. den Heijer T, van der Lijn F, Ikram A, Koudstaal PJ, van der Lugt A, Krestin GP, Vrooman HA, Hofman A, Niessen WJ, Breteler MM. Vascular risk factors, apolipoprotein E, and hippocampal decline on magnetic resonance imaging over a 10-year follow-up. Alzheimers Dement. 2012 Sep; 8(5):417-25.
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  28. Koppelmans V, de Ruiter MB, van der Lijn F, Boogerd W, Seynaeve C, van der Lugt A, Vrooman H, Niessen WJ, Breteler MM, Schagen SB. Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy. Breast Cancer Res Treat. 2012 Apr; 132(3):1099-106.
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  29. Blom JW, de Ruijter W, Witteman JC, Assendelft WJ, Breteler MM, Hofman A, Gussekloo J. Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study. Age (Dordr). 2013 Apr; 35(2):431-8.
    View in: PubMed
  30. Broer L, Koudstaal PJ, Amin N, Rivadeneira F, Uitterlinden AG, Hofman A, Oostra BA, Breteler MM, Ikram MA, van Duijn CM. Association of heat shock proteins with Parkinson's disease. Eur J Epidemiol. 2011 Dec; 26(12):933-5.
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  31. Schrijvers EM, Schürmann B, Koudstaal PJ, van den Bussche H, Van Duijn CM, Hentschel F, Heun R, Hofman A, Jessen F, Kölsch H, Kornhuber J, Peters O, Rivadeneira F, Rüther E, Uitterlinden AG, Riedel-Heller S, Dichgans M, Wiltfang J, Maier W, Breteler MM, Ikram MA. Genome-wide association study of vascular dementia. Stroke. 2012 Feb; 43(2):315-9.
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  32. van der Lijn F, Verhaaren BF, Ikram MA, Klein S, de Bruijne M, Vrooman HA, Vernooij MW, Hammers A, Rueckert D, van der Lugt A, Breteler MM, Niessen WJ. Automated measurement of local white matter lesion volume. Neuroimage. 2012 Feb 15; 59(4):3901-8.
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  33. Koppelmans V, Schagen SB, Poels MM, Boogerd W, Seynaeve C, van der Lugt A, Breteler MM. Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy. Eur J Cancer. 2011 Nov; 47(17):2531-6.
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  34. Ikram MA, van der Lugt A, Niessen WJ, Krestin GP, Koudstaal PJ, Hofman A, Breteler MM, Vernooij MW. The Rotterdam Scan Study: design and update up to 2012. Eur J Epidemiol. 2011 Oct; 26(10):811-24.
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  35. van Durme YM, Lahousse L, Verhamme KM, Stolk L, Eijgelsheim M, Loth DW, Uitterlinden AG, Breteler MM, Joos GF, Hofman A, Stricker BH, Brusselle GG. Mendelian randomization study of interleukin-6 in chronic obstructive pulmonary disease. Respiration. 2011; 82(6):530-8.
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  36. Visser AM, Jaddoe VW, Breteler MM, Hofman A, Moll HA, Arts WF. Frequent fever episodes and the risk of febrile seizures: the Generation R study. Eur J Paediatr Neurol. 2012 Jan; 16(1):29-34.
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  37. Ijsselstijn L, Dekker LJ, Stingl C, van der Weiden MM, Hofman A, Kros JM, Koudstaal PJ, Sillevis Smitt PA, Ikram MA, Breteler MM, Luider TM. Serum levels of pregnancy zone protein are elevated in presymptomatic Alzheimer's disease. J Proteome Res. 2011 Nov 4; 10(11):4902-10.
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  38. van der Lijn F, de Bruijne M, Klein S, den Heijer T, Hoogendam YY, van der Lugt A, Breteler MM, Niessen WJ. Automated brain structure segmentation based on atlas registration and appearance models. IEEE Trans Med Imaging. 2012 Feb; 31(2):276-86.
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  39. Wieberdink RG, Poels MM, Vernooij MW, Koudstaal PJ, Hofman A, van der Lugt A, Breteler MM, Ikram MA. Serum lipid levels and the risk of intracerebral hemorrhage: the Rotterdam Study. Arterioscler Thromb Vasc Biol. 2011 Dec; 31(12):2982-9.
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  40. Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, Ehret GB, Amin N, Larson MG, Mooser V, Hadley D, Dörr M, Bis JC, Aspelund T, Esko T, Janssens AC, Zhao JH, Heath S, Laan M, Fu J, Pistis G, Luan J, Arora P, Lucas G, Pirastu N, Pichler I, Jackson AU, Webster RJ, Zhang F, Peden JF, Schmidt H, Tanaka T, Campbell H, Igl W, Milaneschi Y, Hottenga JJ, Vitart V, Chasman DI, Trompet S, Bragg-Gresham JL, Alizadeh BZ, Chambers JC, Guo X, Lehtimäki T, Kühnel B, Lopez LM, Polašek O, Boban M, Nelson CP, Morrison AC, Pihur V, Ganesh SK, Hofman A, Kundu S, Mattace-Raso FU, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Hwang SJ, Vasan RS, Wang TJ, Bergmann S, Vollenweider P, Waeber G, Laitinen J, Pouta A, Zitting P, McArdle WL, Kroemer HK, Völker U, Völzke H, Glazer NL, Taylor KD, Harris TB, Alavere H, Haller T, Keis A, Tammesoo ML, Aulchenko Y, Barroso I, Khaw KT, Galan P, Hercberg S, Lathrop M, Eyheramendy S, Org E, Sõber S, Lu X, Nolte IM, Penninx BW, Corre T, Masciullo C, Sala C, Groop L, Voight BF, Melander O, O'Donnell CJ, Salomaa V, d'Adamo AP, Fabretto A, Faletra F, Ulivi S, Del Greco F, Facheris M, Collins FS, Bergman RN, Beilby JP, Hung J, Musk AW, Mangino M, Shin SY, Soranzo N, Watkins H, Goel A, Hamsten A, Gider P, Loitfelder M, Zeginigg M, Hernandez D, Najjar SS, Navarro P, Wild SH, Corsi AM, Singleton A, de Geus EJ, Willemsen G, Parker AN, Rose LM, Buckley B, Stott D, Orru M, Uda M, van der Klauw MM, Zhang W, Li X, Scott J, Chen YD, Burke GL, Kähönen M, Viikari J, Döring A, Meitinger T, Davies G, Starr JM, Emilsson V, Plump A, Lindeman JH, Hoen PA, König IR, Felix JF, Clarke R, Hopewell JC, Ongen H, Breteler M, Debette S, Destefano AL, Fornage M, Mitchell GF, Smith NL, Holm H, Stefansson K, Thorleifsson G, Thorsteinsdottir U, Samani NJ, Preuss M, Rudan I, Hayward C, Deary IJ, Wichmann HE, Raitakari OT, Palmas W, Kooner JS, Stolk RP, Jukema JW, Wright AF, Boomsma DI, Bandinelli S, Gyllensten UB, Wilson JF, Ferrucci L, Schmidt R, Farrall M, Spector TD, Palmer LJ, Tuomilehto J, Pfeufer A, Gasparini P, Siscovick D, Altshuler D, Loos RJ, Toniolo D, Snieder H, Gieger C, Meneton P, Wareham NJ, Oostra BA, Metspalu A, Launer L, Rettig R, Strachan DP, Beckmann JS, Witteman JC, Erdmann J, van Dijk KW, Boerwinkle E, Boehnke M, Ridker PM, Jarvelin MR, Chakravarti A, Abecasis GR, Gudnason V, Newton-Cheh C, Levy D, Munroe PB, Psaty BM, Caulfield MJ, Rao DC, Tobin MD, Elliott P, van Duijn CM. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet. 2011 Oct; 43(10):1005-11.
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  41. Verhaaren BF, de Boer R, Vernooij MW, Rivadeneira F, Uitterlinden AG, Hofman A, Krestin GP, van der Lugt A, Niessen WJ, Breteler MM, Ikram MA. Replication study of chr17q25 with cerebral white matter lesion volume. Stroke. 2011 Nov; 42(11):3297-9.
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  42. Schnabel RB, Kerr KF, Lubitz SA, Alkylbekova EL, Marcus GM, Sinner MF, Magnani JW, Wolf PA, Deo R, Lloyd-Jones DM, Lunetta KL, Mehra R, Levy D, Fox ER, Arking DE, Mosley TH, Müller-Nurasyid M, Young TR, Wichmann HE, Seshadri S, Farlow DN, Rotter JI, Soliman EZ, Glazer NL, Wilson JG, Breteler MM, Sotoodehnia N, Newton-Cheh C, Kääb S, Ellinor PT, Alonso A, Benjamin EJ, Heckbert SR. Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project. Circ Cardiovasc Genet. 2011 Oct; 4(5):557-64.
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  43. Boehringer S, van der Lijn F, Liu F, Günther M, Sinigerova S, Nowak S, Ludwig KU, Herberz R, Klein S, Hofman A, Uitterlinden AG, Niessen WJ, Breteler MM, van der Lugt A, Würtz RP, Nöthen MM, Horsthemke B, Wieczorek D, Mangold E, Kayser M. Genetic determination of human facial morphology: links between cleft-lips and normal variation. Eur J Hum Genet. 2011 Nov; 19(11):1192-7.
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  44. Wieberdink RG, Ho L, Ikram MK, Koudstaal PJ, Hofman A, de Jong PT, Vingerling JR, Breteler MM. Age-related macular degeneration and the risk of stroke: the Rotterdam study. Stroke. 2011 Aug; 42(8):2138-42.
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  45. den Heijer T, Tiemeier H, Luijendijk HJ, van der Lijn F, Koudstaal PJ, Hofman A, Breteler MM. A study of the bidirectional association between hippocampal volume on magnetic resonance imaging and depression in the elderly. Biol Psychiatry. 2011 Jul 15; 70(2):191-7.
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  46. Fornage M, Debette S, Bis JC, Schmidt H, Ikram MA, Dufouil C, Sigurdsson S, Lumley T, DeStefano AL, Fazekas F, Vrooman HA, Shibata DK, Maillard P, Zijdenbos A, Smith AV, Gudnason H, de Boer R, Cushman M, Mazoyer B, Heiss G, Vernooij MW, Enzinger C, Glazer NL, Beiser A, Knopman DS, Cavalieri M, Niessen WJ, Harris TB, Petrovic K, Lopez OL, Au R, Lambert JC, Hofman A, Gottesman RF, Garcia M, Heckbert SR, Atwood LD, Catellier DJ, Uitterlinden AG, Yang Q, Smith NL, Aspelund T, Romero JR, Rice K, Taylor KD, Nalls MA, Rotter JI, Sharrett R, van Duijn CM, Amouyel P, Wolf PA, Gudnason V, van der Lugt A, Boerwinkle E, Psaty BM, Seshadri S, Tzourio C, Breteler MM, Mosley TH, Schmidt R, Longstreth WT, DeCarli C, Launer LJ. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol. 2011 Jun; 69(6):928-39.
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  47. Elias-Smale SE, Wieberdink RG, Odink AE, Hofman A, Hunink MG, Koudstaal PJ, Krestin GP, Breteler MM, van der Lugt A, Witteman JC. Burden of atherosclerosis improves the prediction of coronary heart disease but not cerebrovascular events: the Rotterdam Study. Eur Heart J. 2011 Aug; 32(16):2050-8.
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  48. Luijendijk HJ, Stricker BH, Wieberdink RG, Koudstaal PJ, Hofman A, Breteler MM, Tiemeier H. Transient ischemic attack and incident depression. Stroke. 2011 Jul; 42(7):1857-61.
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  49. Mesker DJ, Poels MM, Ikram MA, Vernooij MW, Hofman A, Vrooman HA, van der Lugt A, Breteler MM. Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study. Arch Neurol. 2011 May; 68(5):656-9.
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  50. Schrijvers EM, Koudstaal PJ, Hofman A, Breteler MM. Plasma clusterin and the risk of Alzheimer disease. JAMA. 2011 Apr 6; 305(13):1322-6.
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  53. Medici M, van der Deure WM, Verbiest M, Vermeulen SH, Hansen PS, Kiemeney LA, Hermus AR, Breteler MM, Hofman A, Hegedüs L, Kyvik KO, den Heijer M, Uitterlinden AG, Visser TJ, Peeters RP. A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels. Eur J Endocrinol. 2011 May; 164(5):781-8.
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  64. Visser AM, Jaddoe VW, Arends LR, Tiemeier H, Hofman A, Moll HA, Steegers EA, Breteler MM, Arts WF. Paroxysmal disorders in infancy and their risk factors in a population-based cohort: the Generation R Study. Dev Med Child Neurol. 2010 Nov; 52(11):1014-20.
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  66. Ikram MK, Sim X, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MM, Cheung N, Liew G, Mitchell P, Uitterlinden AG, Rivadeneira F, Hofman A, de Jong PT, van Duijn CM, Kao L, Cheng CY, Smith AV, Glazer NL, Lumley T, McKnight B, Psaty BM, Jonasson F, Eiriksdottir G, Aspelund T, Harris TB, Launer LJ, Taylor KD, Li X, Iyengar SK, Xi Q, Sivakumaran TA, Mackey DA, Macgregor S, Martin NG, Young TL, Bis JC, Wiggins KL, Heckbert SR, Hammond CJ, Andrew T, Fahy S, Attia J, Holliday EG, Scott RJ, Islam FM, Rotter JI, McAuley AK, Boerwinkle E, Tai ES, Gudnason V, Siscovick DS, Vingerling JR, Wong TY. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. PLoS Genet. 2010 Oct; 6(10):e1001184.
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  68. Visser AM, Jaddoe VW, Hofman A, Moll HA, Steegers EA, Tiemeier H, Raat H, Breteler MM, Arts WF. Fetal growth retardation and risk of febrile seizures. Pediatrics. 2010 Oct; 126(4):e919-25.
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  69. Lehmann DJ, Schuur M, Warden DR, Hammond N, Belbin O, Kölsch H, Lehmann MG, Wilcock GK, Brown K, Kehoe PG, Morris CM, Barker R, Coto E, Alvarez V, Deloukas P, Mateo I, Gwilliam R, Combarros O, Arias-Vásquez A, Aulchenko YS, Ikram MA, Breteler MM, van Duijn CM, Oulhaj A, Heun R, Cortina-Borja M, Morgan K, Robson K, Smith AD. Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project. Neurobiol Aging. 2012 Jan; 33(1):202.e1-13.
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  72. Schuur M, van Swieten JC, Schol-Gelok S, Ikram MA, Vernooij MW, Liu F, Isaacs A, de Boer R, de Koning I, Niessen WJ, Vrooman H, Oostra BA, van der Lugt A, Breteler MM, van Duijn CM. Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population. J Neurol Neurosurg Psychiatry. 2011 Jan; 82(1):41-4.
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  73. Devore EE, Grodstein F, van Rooij FJ, Hofman A, Stampfer MJ, Witteman JC, Breteler MM. Dietary antioxidants and long-term risk of dementia. Arch Neurol. 2010 Jul; 67(7):819-25.
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  74. Elias-Smale SE, Odink AE, Wieberdink RG, Hofman A, Hunink MG, Krestin GP, Koudstaal PJ, Breteler MM, van der Lugt A, Witteman JC. Carotid, aortic arch and coronary calcification are related to history of stroke: the Rotterdam Study. Atherosclerosis. 2010 Oct; 212(2):656-60.
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  75. Newson RS, Witteman JC, Franco OH, Stricker BH, Breteler MM, Hofman A, Tiemeier H. Predicting survival and morbidity-free survival to very old age. Age (Dordr). 2010 Dec; 32(4):521-34.
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  76. Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, Longstreth WT, Janssens AC, Pankratz VS, Dartigues JF, Hollingworth P, Aspelund T, Hernandez I, Beiser A, Kuller LH, Koudstaal PJ, Dickson DW, Tzourio C, Abraham R, Antunez C, Du Y, Rotter JI, Aulchenko YS, Harris TB, Petersen RC, Berr C, Owen MJ, Lopez-Arrieta J, Varadarajan BN, Becker JT, Rivadeneira F, Nalls MA, Graff-Radford NR, Campion D, Auerbach S, Rice K, Hofman A, Jonsson PV, Schmidt H, Lathrop M, Mosley TH, Au R, Psaty BM, Uitterlinden AG, Farrer LA, Lumley T, Ruiz A, Williams J, Amouyel P, Younkin SG, Wolf PA, Launer LJ, Lopez OL, van Duijn CM, Breteler MM. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010 May 12; 303(18):1832-40.
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  77. Lorenz MW, Bickel H, Bots ML, Breteler MM, Catapano AL, Desvarieux M, Hedblad B, Iglseder B, Johnsen SH, Juraska M, Kiechl S, Mathiesen EB, Norata GD, Grigore L, Polak J, Poppert H, Rosvall M, Rundek T, Sacco RL, Sander D, Sitzer M, Steinmetz H, Stensland E, Willeit J, Witteman J, Yanez D, Thompson SG. Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project. Am Heart J. 2010 May; 159(5):730-736.e2.
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  80. den Heijer T, van der Lijn F, Koudstaal PJ, Hofman A, van der Lugt A, Krestin GP, Niessen WJ, Breteler MM. A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline. Brain. 2010 Apr; 133(Pt 4):1163-72.
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  82. Rutten JH, Mattace-Raso FU, Steyerberg EW, Lindemans J, Hofman A, Wieberdink RG, Breteler MM, Witteman JC, van den Meiracker AH. Amino-terminal pro-B-type natriuretic peptide improves cardiovascular and cerebrovascular risk prediction in the population: the Rotterdam study. Hypertension. 2010 Mar; 55(3):785-91.
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  84. de Boer R, Schaap M, van der Lijn F, Vrooman HA, de Groot M, Vernooij MW, Ikram MA, van Velsen EF, van der Lugt A, Breteler MM, Niessen WJ. Statistical analysis of structural brain connectivity. Med Image Comput Comput Assist Interv. 2010; 13(Pt 2):101-8.
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  88. Jafari N, Hoppenbrouwers IA, Hop WC, Breteler MM, Hintzen RQ. Cigarette smoking and risk of MS in multiplex families. Mult Scler. 2009 Nov; 15(11):1363-7.
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  92. Odink AE, van der Lugt A, Hofman A, Hunink MG, Breteler MM, Krestin GP, Witteman JC. Risk factors for coronary, aortic arch and carotid calcification; The Rotterdam Study. J Hum Hypertens. 2010 Feb; 24(2):86-92.
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  93. Devore EE, Grodstein F, van Rooij FJ, Hofman A, Rosner B, Stampfer MJ, Witteman JC, Breteler MM. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr. 2009 Jul; 90(1):170-6.
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  94. Donker Kaat L, Boon AJ, Azmani A, Kamphorst W, Breteler MM, Anar B, Heutink P, van Swieten JC. Familial aggregation of parkinsonism in progressive supranuclear palsy. Neurology. 2009 Jul 14; 73(2):98-105.
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  100. Devore EE, Stampfer MJ, Breteler MM, Rosner B, Kang JH, Okereke O, Hu FB, Grodstein F. Dietary fat intake and cognitive decline in women with type 2 diabetes. Diabetes Care. 2009 Apr; 32(4):635-40.
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  108. Ikram MA, Liu F, Oostra BA, Hofman A, van Duijn CM, Breteler MM. The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis. Biol Psychiatry. 2009 Jun 1; 65(11):995-9.
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  109. Vaartjes I, Reitsma JB, de Bruin A, Berger-van Sijl M, Bos MJ, Breteler MM, Grobbee DE, Bots ML. Nationwide incidence of first stroke and TIA in the Netherlands. Eur J Neurol. 2008 Dec; 15(12):1315-23.
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  111. de Lau LM, van Meurs JB, Uitterlinden AG, Smith AD, Refsum H, Johnston C, Breteler MM. Genetic variation in homocysteine metabolism, cognition, and white matter lesions. Neurobiol Aging. 2010 Nov; 31(11):2020-2.
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  113. de Lau LM, Smith AD, Refsum H, Johnston C, Breteler MM. Plasma vitamin B12 status and cerebral white-matter lesions. J Neurol Neurosurg Psychiatry. 2009 Feb; 80(2):149-57.
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  114. Haag MD, Hofman A, Koudstaal PJ, Stricker BH, Breteler MM. Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J Neurol Neurosurg Psychiatry. 2009 Jan; 80(1):13-7.
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  115. van der Deure WM, Peeters RP, Uitterlinden AG, Hofman A, Breteler MM, Witteman J, Visser TJ. Impact of thyroid function and polymorphisms in the type 2 deiodinase on blood pressure: the Rotterdam Study and the Rotterdam Scan Study. Clin Endocrinol (Oxf). 2009 Jul; 71(1):137-44.
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  116. Verwoert GC, Mattace-Raso FU, Hofman A, Heeringa J, Stricker BH, Breteler MM, Witteman JC. Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam study. J Am Geriatr Soc. 2008 Oct; 56(10):1816-20.
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  120. Cheung EY, Bos MJ, Leebeek FW, Koudstaal PJ, Hofman A, de Maat MP, Breteler MM. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. Thromb Haemost. 2008 Aug; 100(2):308-13.
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  121. van Dijk EJ, Prins ND, Vrooman HA, Hofman A, Koudstaal PJ, Breteler MM. Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study. Stroke. 2008 Oct; 39(10):2712-9.
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  122. Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, Wautrecht JC, Kornitzer M, Newman AB, Cushman M, Sutton-Tyrrell K, Fowkes FG, Lee AJ, Price JF, d'Agostino RB, Murabito JM, Norman PE, Jamrozik K, Curb JD, Masaki KH, Rodríguez BL, Dekker JM, Bouter LM, Heine RJ, Nijpels G, Stehouwer CD, Ferrucci L, McDermott MM, Stoffers HE, Hooi JD, Knottnerus JA, Ogren M, Hedblad B, Witteman JC, Breteler MM, Hunink MG, Hofman A, Criqui MH, Langer RD, Fronek A, Hiatt WR, Hamman R, Resnick HE, Guralnik J, McDermott MM. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008 Jul 9; 300(2):197-208.
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  123. Reitz C, van Rooij FJ, Soares HD, de Maat MP, Hofman A, Witteman JC, Breteler MM. Matrix metalloproteinase 3 haplotypes and plasma amyloid beta levels: the Rotterdam Study. Neurobiol Aging. 2010 Apr; 31(4):715-8.
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  124. Poels MM, Ikram MA, Vernooij MW, Krestin GP, Hofman A, Niessen WJ, van der Lugt A, Breteler MM. Total cerebral blood flow in relation to cognitive function: the Rotterdam Scan Study. J Cereb Blood Flow Metab. 2008 Oct; 28(10):1652-5.
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  125. Haag MD, Bos MJ, Hofman A, Koudstaal PJ, Breteler MM, Stricker BH. Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs and risk of stroke. Arch Intern Med. 2008 Jun 9; 168(11):1219-24.
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  126. Ikram MA, Vrooman HA, Vernooij MW, den Heijer T, Hofman A, Niessen WJ, van der Lugt A, Koudstaal PJ, Breteler MM. Brain tissue volumes in relation to cognitive function and risk of dementia. Neurobiol Aging. 2010 Mar; 31(3):378-86.
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  127. van der Deure WM, Friesema EC, de Jong FJ, de Rijke YB, de Jong FH, Uitterlinden AG, Breteler MM, Peeters RP, Visser TJ. Organic anion transporter 1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism. Endocrinology. 2008 Sep; 149(9):4695-701.
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  128. Vernooij MW, van der Lugt A, Breteler MM. Risk of thrombolysis-related hemorrhage associated with microbleed presence. Stroke. 2008 Jul; 39(7):e115; author reply e116.
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  129. Vernooij MW, Ikram MA, Wielopolski PA, Krestin GP, Breteler MM, van der Lugt A. Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection. Radiology. 2008 Jul; 248(1):272-7.
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  130. Euser SM, Schram MT, Hofman A, Westendorp RG, Breteler MM. Measuring cognitive function with age: the influence of selection by health and survival. Epidemiology. 2008 May; 19(3):440-7.
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  131. Geerlings MI, den Heijer T, Koudstaal PJ, Hofman A, Breteler MM. History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease. Neurology. 2008 Apr 8; 70(15):1258-64.
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  132. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, Krestin GP, Breteler MM. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology. 2008 Apr 1; 70(14):1208-14.
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  133. Arias-Vásquez A, Aulchenko YS, Isaacs A, van Oosterhout A, Sleegers K, Hofman A, van Broeckhoven C, Oostra BA, Breteler M, van Duijn CM. Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study. J Neurol. 2008 May; 255(5):655-62.
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  134. Schelleman H, Klungel OH, Witteman JC, Breteler MM, Hofman A, van Duijn CM, de Boer A, Stricker BH. Interaction between polymorphisms in the renin-angiotensin-system and angiotensin-converting enzyme inhibitor or beta-blocker use and the risk of myocardial infarction and stroke. Pharmacogenomics J. 2008 Dec; 8(6):400-7.
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  135. Ikram MA, van Oijen M, de Jong FJ, Kors JA, Koudstaal PJ, Hofman A, Witteman JC, Breteler MM. Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease. Stroke. 2008 May; 39(5):1421-6.
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  136. Bos MJ, Schuit SC, Koudstaal PJ, Hofman A, Uitterlinden AG, Breteler MM. Variation in the estrogen receptor alpha gene and risk of stroke: the Rotterdam Study. Stroke. 2008 Apr; 39(4):1324-6.
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  137. Bos MJ, Lindén T, Koudstaal PJ, Hofman A, Skoog I, Breteler MM, Tiemeier H. Depressive symptoms and risk of stroke: the Rotterdam Study. J Neurol Neurosurg Psychiatry. 2008 Sep; 79(9):997-1001.
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  138. Odink AE, Mattace-Raso FU, van der Lugt A, Hofman A, Hunink MG, Breteler MM, Krestin GP, Witteman JC. The association of arterial stiffness and arterial calcification: the Rotterdam study. J Hum Hypertens. 2008 Mar; 22(3):205-7.
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  139. Bos MJ, van Rijn MJ, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Incidence and prognosis of transient neurological attacks. JAMA. 2007 Dec 26; 298(24):2877-85.
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  140. de Jong FJ, Vernooij MW, Ikram MK, Ikram MA, Hofman A, Krestin GP, van der Lugt A, de Jong PT, Breteler MM. Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters. The Rotterdam Study. Ophthalmology. 2008 May; 115(5):887-92.
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  141. Ikram MA, Vernooij MW, Hofman A, Niessen WJ, van der Lugt A, Breteler MM. Kidney function is related to cerebral small vessel disease. Stroke. 2008 Jan; 39(1):55-61.
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  142. Reitz C, Bos MJ, Hofman A, Koudstaal PJ, Breteler MM. Prestroke cognitive performance, incident stroke, and risk of dementia: the Rotterdam Study. Stroke. 2008 Jan; 39(1):36-41.
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  143. Vernooij MW, Ikram MA, Tanghe HL, Vincent AJ, Hofman A, Krestin GP, Niessen WJ, Breteler MM, van der Lugt A. Incidental findings on brain MRI in the general population. N Engl J Med. 2007 Nov 1; 357(18):1821-8.
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  144. Schram MT, Trompet S, Kamper AM, de Craen AJ, Hofman A, Euser SM, Breteler MM, Westendorp RG. Serum calcium and cognitive function in old age. J Am Geriatr Soc. 2007 Nov; 55(11):1786-92.
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  145. Bos MJ, Koudstaal PJ, Hofman A, Breteler MM. Decreased glomerular filtration rate is a risk factor for hemorrhagic but not for ischemic stroke: the Rotterdam Study. Stroke. 2007 Dec; 38(12):3127-32.
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  146. Hofman A, Breteler MM, van Duijn CM, Krestin GP, Pols HA, Stricker BH, Tiemeier H, Uitterlinden AG, Vingerling JR, Witteman JC. The Rotterdam Study: objectives and design update. Eur J Epidemiol. 2007; 22(11):819-29.
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  147. van Oijen M, Cheung EY, Geluk CE, Hofman A, Koudstaal PJ, Breteler MM, de Maat MP. Haplotypes of the fibrinogen gene and cerebral small vessel disease: the Rotterdam scan study. J Neurol Neurosurg Psychiatry. 2008 Jul; 79(7):799-803.
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  148. de Lau LM, Stricker BH, Breteler MM. Serum cholesterol, use of lipid-lowering drugs, and risk of Parkinson disease. Mov Disord. 2007 Oct 15; 22(13):1985.
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  149. The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol. 2007; 22(12):839-69.
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  150. de Jong FJ, Masaki K, Chen H, Remaley AT, Breteler MM, Petrovitch H, White LR, Launer LJ. Thyroid function, the risk of dementia and neuropathologic changes: the Honolulu-Asia aging study. Neurobiol Aging. 2009 Apr; 30(4):600-6.
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  151. Bornebroek M, de Lau LM, Haag MD, Koudstaal PJ, Hofman A, Stricker BH, Breteler MM. Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease. Neuroepidemiology. 2007; 28(4):193-6.
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  152. Reitz C, den Heijer T, van Duijn C, Hofman A, Breteler MM. Relation between smoking and risk of dementia and Alzheimer disease: the Rotterdam Study. Neurology. 2007 Sep 4; 69(10):998-1005.
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  153. Ikram MA, Vernooij MW, Vrooman HA, Hofman A, Breteler MM. Brain tissue volumes and small vessel disease in relation to the risk of mortality. Neurobiol Aging. 2009 Mar; 30(3):450-6.
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  154. de Lau LM, Refsum H, Smith AD, Johnston C, Breteler MM. Plasma folate concentration and cognitive performance: Rotterdam Scan Study. Am J Clin Nutr. 2007 Sep; 86(3):728-34.
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  155. Bos MJ, Koudstaal PJ, Hofman A, Witteman JC, Breteler MM. Transcranial Doppler hemodynamic parameters and risk of stroke: the Rotterdam study. Stroke. 2007 Sep; 38(9):2453-8.
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  156. Arias-Vásquez A, de Lau L, Pardo L, Liu F, Feng BJ, Bertoli-Avella A, Isaacs A, Aulchenko Y, Hofman A, Oostra B, Breteler M, van Duijn C. Relationship of the Ubiquilin 1 gene with Alzheimer's and Parkinson's disease and cognitive function. Neurosci Lett. 2007 Aug 31; 424(1):1-5.
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  157. Alizadeh BZ, Njajou OT, Millán MR, Hofman A, Breteler MM, van Duijn CM. HFE variants, APOE and Alzheimer's disease: findings from the population-based Rotterdam study. Neurobiol Aging. 2009 Feb; 30(2):330-2.
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  158. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Vrooman HA, Hofman A, Krestin GP, Breteler MM. Total cerebral blood flow and total brain perfusion in the general population: the Rotterdam Scan Study. J Cereb Blood Flow Metab. 2008 Feb; 28(2):412-9.
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  159. de Jong FJ, Ikram MK, Despriet DD, Uitterlinden AG, Hofman A, Breteler MM, de Jong PT. Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study. Invest Ophthalmol Vis Sci. 2007 Jul; 48(7):3014-8.
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  160. Reitz C, Berger K, de Maat MP, Stoll M, Friedrichs F, Kardys I, Witteman JC, Breteler MM. CRP gene haplotypes, serum CRP, and cerebral small-vessel disease: the Rotterdam Scan Study and the MEMO Study. Stroke. 2007 Aug; 38(8):2356-9.
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  161. Vrooman HA, Cocosco CA, van der Lijn F, Stokking R, Ikram MA, Vernooij MW, Breteler MM, Niessen WJ. Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification. Neuroimage. 2007 Aug 1; 37(1):71-81.
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  162. Arias-Vásquez A, Isaacs A, Aulchenko YS, Hofman A, Oostra BA, Breteler M, van Duijn CM. The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease. Neurogenetics. 2007 Aug; 8(3):189-93.
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  163. de Jong FJ, Ikram MK, Witteman JC, Hofman A, de Jong PT, Breteler MM. Retinal vessel diameters and the role of inflammation in cerebrovascular disease. Ann Neurol. 2007 May; 61(5):491-5.
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  164. van Oijen M, de Jong FJ, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Atherosclerosis and risk for dementia. Ann Neurol. 2007 May; 61(5):403-10.
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  165. Schram MT, Euser SM, de Craen AJ, Witteman JC, Frölich M, Hofman A, Jolles J, Breteler MM, Westendorp RG. Systemic markers of inflammation and cognitive decline in old age. J Am Geriatr Soc. 2007 May; 55(5):708-16.
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  166. Frigerio R, Breteler MM, de Lau LM, Sanft KR, Bower JH, Ahlskog JE, Grossardt BR, Maraganore DM, Rocca WA. Number of children and risk of Parkinson's disease. Mov Disord. 2007 Apr 15; 22(5):632-9.
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  167. van Oijen M, de Jong FJ, Hofman A, Koudstaal PJ, Breteler MM. Subjective memory complaints, education, and risk of Alzheimer's disease. Alzheimers Dement. 2007 Apr; 3(2):92-7.
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  168. Reitz C, van Rooij FJ, de Maat MP, den Heijer T, Hofman A, Witteman JC, Breteler MM. Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease. The Rotterdam Study. Neurobiol Aging. 2008 Jun; 29(6):874-81.
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  169. Schelleman H, Klungel OH, Witteman JC, Breteler MM, Yazdanpanah M, Danser AH, Hofman A, van Duijn CM, de Boer A, Stricker BH. Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. Eur J Hum Genet. 2007 Apr; 15(4):478-84.
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  170. Poels MM, van Oijen M, Mattace-Raso FU, Hofman A, Koudstaal PJ, Witteman JC, Breteler MM. Arterial stiffness, cognitive decline, and risk of dementia: the Rotterdam study. Stroke. 2007 Mar; 38(3):888-92.
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  171. Ikram MA, Vrooman HA, Vernooij MW, van der Lijn F, Hofman A, van der Lugt A, Niessen WJ, Breteler MM. Brain tissue volumes in the general elderly population. The Rotterdam Scan Study. Neurobiol Aging. 2008 Jun; 29(6):882-90.
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  172. van Rijn MJ, Bos MJ, Isaacs A, Yazdanpanah M, Arias-Vásquez A, Stricker BH, Klungel OH, Oostra BA, Koudstaal PJ, Witteman JC, Hofman A, Breteler MM, van Duijn CM. Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. J Neurol Neurosurg Psychiatry. 2007 Oct; 78(10):1083-7.
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  173. Schelleman H, Klungel OH, Witteman JC, Breteler MM, Hofman A, van Duijn CM, de Boer A, Stricker BH. Diuretic-gene interaction and the risk of myocardial infarction and stroke. Pharmacogenomics J. 2007 Oct; 7(5):346-52.
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  174. van Rossum EF, de Jong FJ, Koper JW, Uitterlinden AG, Prins ND, van Dijk EJ, Koudstaal PJ, Hofman A, de Jong FH, Lamberts SW, Breteler MM. Glucocorticoid receptor variant and risk of dementia and white matter lesions. Neurobiol Aging. 2008 May; 29(5):716-23.
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  175. López-León S, Janssens AC, Hofman A, Claes S, Breteler MM, Tiemeier H, van Duijn CM. No association between the angiotensin-converting enzyme gene and major depression: a case-control study and meta-analysis. Psychiatr Genet. 2006 Dec; 16(6):225-6.
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  176. de Jong FJ, Peeters RP, den Heijer T, van der Deure WM, Hofman A, Uitterlinden AG, Visser TJ, Breteler MM. The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe. J Clin Endocrinol Metab. 2007 Feb; 92(2):636-40.
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  177. Ikram MA, Hollander M, Bos MJ, Kors JA, Koudstaal PJ, Hofman A, Witteman JC, Breteler MM. Unrecognized myocardial infarction and the risk of stroke: the Rotterdam Study. Neurology. 2006 Nov 14; 67(9):1635-9.
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  178. van Rijn MJ, Bos MJ, Yazdanpanah M, Isaacs A, Arias-Vásquez A, Koudstaal PJ, Hofman A, Witteman JC, van Duijn CM, Breteler MM. Alpha-adducin polymorphism, atherosclerosis, and cardiovascular and cerebrovascular risk. Stroke. 2006 Dec; 37(12):2930-4.
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  179. Naarding P, Tiemeier H, Breteler MM, Schoevers RA, Jonker C, Koudstaal PJ, Beekman AT. Clinically defined vascular depression in the general population. Psychol Med. 2007 Mar; 37(3):383-92.
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  180. Tiemeier H, Fekkes D, Hofman A, van Tuijl HR, Kiliaan AJ, Breteler MM. Plasma pterins and folate in late life depression: the Rotterdam Study. Psychiatry Res. 2006 Dec 7; 145(2-3):199-206.
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  181. Smit P, Dekker MJ, de Jong FJ, van den Beld AW, Koper JW, Pols HA, Brinkmann AO, de Jong FH, Breteler MM, Lamberts SW. Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia. J Clin Endocrinol Metab. 2007 Jan; 92(1):359-62.
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  182. Sie MP, Uitterlinden AG, Bos MJ, Arp PP, Breteler MM, Koudstaal PJ, Pols HA, Hofman A, van Duijn CM, Witteman JC. TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study. Stroke. 2006 Nov; 37(11):2667-71.
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  183. Bos MJ, Schipper CM, Koudstaal PJ, Witteman JC, Hofman A, Breteler MM. High serum C-reactive protein level is not an independent predictor for stroke: the Rotterdam Study. Circulation. 2006 Oct 10; 114(15):1591-8.
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  184. Odink AE, van der Lugt A, Hofman A, Hunink MG, Breteler MM, Krestin GP, Witteman JC. Association between calcification in the coronary arteries, aortic arch and carotid arteries: the Rotterdam study. Atherosclerosis. 2007 Aug; 193(2):408-13.
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  185. Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, Powers WJ, DeCarli C, Merino JG, Kalaria RN, Vinters HV, Holtzman DM, Rosenberg GA, Wallin A, Dichgans M, Marler JR, Leblanc GG. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006 Sep; 37(9):2220-41.
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  186. de Lau LM, Koudstaal PJ, Hofman A, Breteler MM. Serum cholesterol levels and the risk of Parkinson's disease. Am J Epidemiol. 2006 Nov 15; 164(10):998-1002.
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  187. van Oijen M, Hofman A, Soares HD, Koudstaal PJ, Breteler MM. Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study. Lancet Neurol. 2006 Aug; 5(8):655-60.
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  188. de Lau LM, Koudstaal PJ, Witteman JC, Hofman A, Breteler MM. Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. Neurology. 2006 Jul 25; 67(2):315-8.
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  189. van Oijen M, de Maat MP, Kardys I, de Jong FJ, Hofman A, Koudstaal PJ, Witteman JC, Breteler MM. Polymorphisms and haplotypes in the C-reactive protein gene and risk of dementia. Neurobiol Aging. 2007 Sep; 28(9):1361-6.
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  190. Heeringa J, Conway DS, van der Kuip DA, Hofman A, Breteler MM, Lip GY, Witteman JC. A longitudinal population-based study of prothrombotic factors in elderly subjects with atrial fibrillation: the Rotterdam Study 1990-1999. J Thromb Haemost. 2006 Sep; 4(9):1944-9.
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  191. Hofman A, de Jong PT, van Duijn CM, Breteler MM. Epidemiology of neurological diseases in elderly people: what did we learn from the Rotterdam Study? Lancet Neurol. 2006 Jun; 5(6):545-50.
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  192. de Lau LM, Breteler MM. Epidemiology of Parkinson's disease. Lancet Neurol. 2006 Jun; 5(6):525-35.
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  193. van Dijk EJ, Prins ND, Hofman A, van Duijn CM, Koudstaal PJ, Breteler MM. Plasma beta amyloid and impaired CO2-induced cerebral vasomotor reactivity. Neurobiol Aging. 2007 May; 28(5):707-12.
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  194. Ikram MK, de Jong FJ, Bos MJ, Vingerling JR, Hofman A, Koudstaal PJ, de Jong PT, Breteler MM. Retinal vessel diameters and risk of stroke: the Rotterdam Study. Neurology. 2006 May 9; 66(9):1339-43.
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  195. Bos MJ, Koudstaal PJ, Hofman A, Witteman JC, Breteler MM. Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. Stroke. 2006 Jun; 37(6):1503-7.
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  196. van Oijen M, Arp PP, de Jong FJ, Hofman A, Koudstaal PJ, Uitterlinden AG, Breteler MM. Polymorphisms in the interleukin 6 and transforming growth factor beta1 gene and risk of dementia. The Rotterdam Study. Neurosci Lett. 2006 Jul 10; 402(1-2):113-7.
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  197. de Jong FJ, den Heijer T, Visser TJ, de Rijke YB, Drexhage HA, Hofman A, Breteler MM. Thyroid hormones, dementia, and atrophy of the medial temporal lobe. J Clin Endocrinol Metab. 2006 Jul; 91(7):2569-73.
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  198. den Heijer T, Sijens PE, Prins ND, Hofman A, Koudstaal PJ, Oudkerk M, Breteler MM. MR spectroscopy of brain white matter in the prediction of dementia. Neurology. 2006 Feb 28; 66(4):540-4.
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  199. Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, Asmar R, Reneman RS, Hoeks AP, Breteler MM, Witteman JC. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006 Feb 7; 113(5):657-63.
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  200. Ikram MK, Janssen JA, Roos AM, Rietveld I, Witteman JC, Breteler MM, Hofman A, van Duijn CM, de Jong PT. Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the Rotterdam study. Diabetes. 2006 Feb; 55(2):506-10.
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  201. de Lau LM, Koudstaal PJ, Hofman A, Breteler MM. Subjective complaints precede Parkinson disease: the rotterdam study. Arch Neurol. 2006 Mar; 63(3):362-5.
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  202. den Heijer T, Geerlings MI, Hoebeek FE, Hofman A, Koudstaal PJ, Breteler MM. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people. Arch Gen Psychiatry. 2006 Jan; 63(1):57-62.
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  203. Söderlund H, Nilsson LG, Berger K, Breteler MM, Dufouil C, Fuhrer R, Giampaoli S, Hofman A, Pajak A, de Ridder M, Sans S, Schmidt R, Launer LJ. Cerebral changes on MRI and cognitive function: the CASCADE study. Neurobiol Aging. 2006 Jan; 27(1):16-23.
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  204. van Rijn MJ, Slooter AJ, Bos MJ, Catarino CF, Koudstaal PJ, Hofman A, Breteler MM, van Duijn CM. Insulin-like growth factor I promoter polymorphism, risk of stroke, and survival after stroke: the Rotterdam study. J Neurol Neurosurg Psychiatry. 2006 Jan; 77(1):24-7.
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  205. van Oijen M, van der Meer IM, Hofman A, Witteman JC, Koudstaal PJ, Breteler MM. Lipoprotein-associated phospholipase A2 is associated with risk of dementia. Ann Neurol. 2006 Jan; 59(1):139-44.
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  206. Ikram MK, Witteman JC, Vingerling JR, Breteler MM, Hofman A, de Jong PT. Retinal vessel diameters and risk of hypertension: the Rotterdam Study. Hypertension. 2006 Feb; 47(2):189-94.
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  207. Kardys I, Oei HH, van der Meer IM, Hofman A, Breteler MM, Witteman JC. Lipoprotein-associated phospholipase A2 and measures of extracoronary atherosclerosis: the Rotterdam Study. Arterioscler Thromb Vasc Biol. 2006 Mar; 26(3):631-6.
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  208. Ikram MK, De Jong FJ, Van Dijk EJ, Prins ND, Hofman A, Breteler MM, De Jong PT. Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study. Brain. 2006 Jan; 129(Pt 1):182-8.
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  209. van Oijen M, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia. Stroke. 2005 Dec; 36(12):2637-41.
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  210. de Lau LM, Koudstaal PJ, Hofman A, Breteler MM. Serum uric acid levels and the risk of Parkinson disease. Ann Neurol. 2005 Nov; 58(5):797-800.
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  211. Launer LJ, Berger K, Breteler MM, Dufouil C, Fuhrer R, Giampaoli S, Nilsson LG, Pajak A, de Ridder M, van Dijk EJ, Sans S, Schmidt R, Hofman A. Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries (CASCADE). Neuroepidemiology. 2006; 26(1):23-9.
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  212. Tiemeier H, Breteler MM, Hofman A, Stijnen T. A multivariate score objectively assessed health of depressed elderly. J Clin Epidemiol. 2005 Nov; 58(11):1134-41.
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  213. Tiemeier H, Schuit SC, den Heijer T, van Meurs JB, van Tuijl HR, Hofman A, Breteler MM, Pols HA, Uitterlinden AG. Estrogen receptor alpha gene polymorphisms and anxiety disorder in an elderly population. Mol Psychiatry. 2005 Sep; 10(9):806-7.
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  214. van Dijk EJ, Prins ND, Vermeer SE, Vrooman HA, Hofman A, Koudstaal PJ, Breteler MM. C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study. Circulation. 2005 Aug 9; 112(6):900-5.
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  215. de Lau LM, Schipper CM, Hofman A, Koudstaal PJ, Breteler MM. Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study. Arch Neurol. 2005 Aug; 62(8):1265-9.
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  216. de Lau LM, Bornebroek M, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study. Neurology. 2005 Jun 28; 64(12):2040-5.
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  217. Prins ND, van Dijk EJ, den Heijer T, Vermeer SE, Jolles J, Koudstaal PJ, Hofman A, Breteler MM. Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain. 2005 Sep; 128(Pt 9):2034-41.
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  218. Ruitenberg A, den Heijer T, Bakker SL, van Swieten JC, Koudstaal PJ, Hofman A, Breteler MM. Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann Neurol. 2005 Jun; 57(6):789-94.
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  219. de Lau LM, Koudstaal PJ, van Meurs JB, Uitterlinden AG, Hofman A, Breteler MM. Methylenetetrahydrofolate reductase C677T genotype and PD. Ann Neurol. 2005 Jun; 57(6):927-30.
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  220. den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Serum lipids and hippocampal volume: the link to Alzheimer's disease? Ann Neurol. 2005 May; 57(5):779-80; author reply 7780.
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  221. Ikram MK, de Voogd S, Wolfs RC, Hofman A, Breteler MM, Hubbard LD, de Jong PT. Retinal vessel diameters and incident open-angle glaucoma and optic disc changes: the Rotterdam study. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1182-7.
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  222. Oei HH, van der Meer IM, Hofman A, Koudstaal PJ, Stijnen T, Breteler MM, Witteman JC. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam Study. Circulation. 2005 Feb 8; 111(5):570-5.
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  223. den Heijer T, Launer LJ, Prins ND, van Dijk EJ, Vermeer SE, Hofman A, Koudstaal PJ, Breteler MM. Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe. Neurology. 2005 Jan 25; 64(2):263-7.
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  224. Engelhart MJ, Ruitenberg A, Meijer J, Kiliaan A, van Swieten JC, Hofman A, Witteman JC, Breteler MM. Plasma levels of antioxidants are not associated with Alzheimer's disease or cognitive decline. Dement Geriatr Cogn Disord. 2005; 19(2-3):134-9.
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  225. den Heijer T, Schuit SC, Pols HA, van Meurs JB, Hofman A, Koudstaal PJ, van Duijn CM, Uitterlinden AG, Breteler MM. Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI. Mol Psychiatry. 2004 Dec; 9(12):1129-35.
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  226. Sleegers K, den Heijer T, van Dijk EJ, Hofman A, Bertoli-Avella AM, Koudstaal PJ, Breteler MM, van Duijn CM. ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala. Neurobiol Aging. 2005 Aug-Sep; 26(8):1153-9.
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  227. de Lau LM, Giesbergen PC, de Rijk MC, Hofman A, Koudstaal PJ, Breteler MM. Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study. Neurology. 2004 Oct 12; 63(7):1240-4.
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  228. van Dijk EJ, Breteler MM, Schmidt R, Berger K, Nilsson LG, Oudkerk M, Pajak A, Sans S, de Ridder M, Dufouil C, Fuhrer R, Giampaoli S, Launer LJ, Hofman A. The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study. Hypertension. 2004 Nov; 44(5):625-30.
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  229. Prins ND, van Dijk EJ, den Heijer T, Vermeer SE, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM. Cerebral white matter lesions and the risk of dementia. Arch Neurol. 2004 Oct; 61(10):1531-4.
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  230. den Heijer T, Vermeer SE, van Dijk EJ, Prins ND, Koudstaal PJ, van Duijn CM, Hofman A, Breteler MM. Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia. Am J Clin Nutr. 2004 Oct; 80(4):992-7.
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  231. Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F. Physical activity, including walking, and cognitive function in older women. JAMA. 2004 Sep 22; 292(12):1454-61.
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  232. Mattace-Raso FU, van der Cammen TJ, van Popele NM, van der Kuip DA, Schalekamp MA, Hofman A, Breteler MM, Witteman JC. Blood pressure components and cardiovascular events in older adults: the Rotterdam study. J Am Geriatr Soc. 2004 Sep; 52(9):1538-42.
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  233. Vokó Z, Hollander M, Koudstaal PJ, Hofman A, Breteler MM. How do American stroke risk functions perform in a Western European population? Neuroepidemiology. 2004 Sep-Oct; 23(5):247-53.
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  234. Artero S, Tiemeier H, Prins ND, Sabatier R, Breteler MM, Ritchie K. Neuroanatomical localisation and clinical correlates of white matter lesions in the elderly. J Neurol Neurosurg Psychiatry. 2004 Sep; 75(9):1304-8.
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  235. Bakker SL, de Leeuw FE, den Heijer T, Koudstaal PJ, Hofman A, Breteler MM. Cerebral haemodynamics in the elderly: the rotterdam study. Neuroepidemiology. 2004 Jul-Aug; 23(4):178-84.
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  236. Ikram MK, de Jong FJ, Vingerling JR, Witteman JC, Hofman A, Breteler MM, de Jong PT. Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study. Invest Ophthalmol Vis Sci. 2004 Jul; 45(7):2129-34.
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  237. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, de Groot LC, Hofman A, Witteman JC, van Leeuwen JP, Breteler MM, Lips P, Pols HA, Uitterlinden AG. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004 May 13; 350(20):2033-41.
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  238. Prins ND, van Straaten EC, van Dijk EJ, Simoni M, van Schijndel RA, Vrooman HA, Koudstaal PJ, Scheltens P, Breteler MM, Barkhof F. Measuring progression of cerebral white matter lesions on MRI: visual rating and volumetrics. Neurology. 2004 May 11; 62(9):1533-9.
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  239. Engelhart MJ, Geerlings MI, Meijer J, Kiliaan A, Ruitenberg A, van Swieten JC, Stijnen T, Hofman A, Witteman JC, Breteler MM. Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. Arch Neurol. 2004 May; 61(5):668-72.
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  240. van Dijk EJ, Vermeer SE, de Groot JC, van de Minkelis J, Prins ND, Oudkerk M, Hofman A, Koudstaal PJ, Breteler MM. Arterial oxygen saturation, COPD, and cerebral small vessel disease. J Neurol Neurosurg Psychiatry. 2004 May; 75(5):733-6.
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  241. Slooter AJ, Cruts M, Hofman A, Koudstaal PJ, van der Kuip D, de Ridder MA, Witteman JC, Breteler MM, Van Broeckhoven C, van Duijn CM. The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study. Neurology. 2004 Apr 13; 62(7):1196-8.
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  242. de Leeuw FE, Richard F, de Groot JC, van Duijn CM, Hofman A, Van Gijn J, Breteler MM. Interaction between hypertension, apoE, and cerebral white matter lesions. Stroke. 2004 May; 35(5):1057-60.
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  243. Tiemeier H, van Dijck W, Hofman A, Witteman JC, Stijnen T, Breteler MM. Relationship between atherosclerosis and late-life depression: the Rotterdam Study. Arch Gen Psychiatry. 2004 Apr; 61(4):369-76.
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  244. van Dijk EJ, Prins ND, Vermeer SE, Hofman A, van Duijn CM, Koudstaal PJ, Breteler MM. Plasma amyloid beta, apolipoprotein E, lacunar infarcts, and white matter lesions. Ann Neurol. 2004 Apr; 55(4):570-5.
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  245. Maitland-van der Zee AH, Klungel OH, Stricker BH, Verschuren WM, Witteman JC, Stijnen T, Hofman A, Breteler MM, Leufkens HG, de Boer A. Comparison of two methodologies to analyze exposure to statins in an observational study on effectiveness. J Clin Epidemiol. 2004 Mar; 57(3):237-42.
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  246. Schmidt R, Launer LJ, Nilsson LG, Pajak A, Sans S, Berger K, Breteler MM, de Ridder M, Dufouil C, Fuhrer R, Giampaoli S, Hofman A. Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes. 2004 Mar; 53(3):687-92.
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  247. Vokó Z, Hollander M, Hofman A, Koudstaal PJ, Breteler MM. Dietary antioxidants and the risk of ischemic stroke: the Rotterdam Study. Neurology. 2003 Nov 11; 61(9):1273-5.
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  248. den Heijer T, Vermeer SE, van Dijk EJ, Prins ND, Koudstaal PJ, Hofman A, Breteler MM. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia. 2003 Dec; 46(12):1604-10.
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  249. Dekker MC, Giesbergen PC, Njajou OT, van Swieten JC, Hofman A, Breteler MM, van Duijn CM. Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism. Neurosci Lett. 2003 Sep 11; 348(2):117-9.
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  250. Hollander M, Hak AE, Koudstaal PJ, Bots ML, Grobbee DE, Hofman A, Witteman JC, Breteler MM. Comparison between measures of atherosclerosis and risk of stroke: the Rotterdam Study. Stroke. 2003 Oct; 34(10):2367-72.
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  251. Dekker MC, van Swieten JC, Houwing-Duistermaat JJ, Snijders PJ, Boeren E, Hofman A, Breteler MM, Heutink P, Oostra BA, van Duijn CM. A clinical-genetic study of Parkinson's disease in a genetically isolated community. J Neurol. 2003 Sep; 250(9):1056-62.
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  252. Croes EA, Dermaut B, Houwing-Duistermaat JJ, Van den Broeck M, Cruts M, Breteler MM, Hofman A, van Broeckhoven C, van Duijn CM. Early cognitive decline is associated with prion protein codon 129 polymorphism. Ann Neurol. 2003 Aug; 54(2):275-6.
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  253. Tiemeier H, Breteler MM, van Popele NM, Hofman A, Witteman JC. Late-life depression is associated with arterial stiffness: a population-based study. J Am Geriatr Soc. 2003 Aug; 51(8):1105-10.
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  254. Tiemeier H, van Tuijl HR, Hofman A, Kiliaan AJ, Breteler MM. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study. Am J Clin Nutr. 2003 Jul; 78(1):40-6.
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  255. Geerlings MI, Launer LJ, de Jong FH, Ruitenberg A, Stijnen T, van Swieten JC, Hofman A, Witteman JC, Pols HA, Breteler MM. Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study. Ann Neurol. 2003 May; 53(5):607-15.
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  256. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke. 2003 May; 34(5):1126-9.
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  257. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003 Mar 27; 348(13):1215-22.
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  258. Heijer Td, Skoog I, Oudkerk M, de Leeuw FE, de Groot JC, Hofman A, Breteler MM. Association between blood pressure levels over time and brain atrophy in the elderly. Neurobiol Aging. 2003 Mar-Apr; 24(2):307-13.
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  259. Hollander M, Koudstaal PJ, Bots ML, Grobbee DE, Hofman A, Breteler MM. Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study. J Neurol Neurosurg Psychiatry. 2003 Mar; 74(3):317-21.
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  260. den Heijer T, Geerlings MI, Hofman A, de Jong FH, Launer LJ, Pols HA, Breteler MM. Higher estrogen levels are not associated with larger hippocampi and better memory performance. Arch Neurol. 2003 Feb; 60(2):213-20.
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  261. Vermeer SE, Den Heijer T, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke. 2003 Feb; 34(2):392-6.
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  262. Sijens PE, den Heijer T, Origgi D, Vermeer SE, Breteler MM, Hofman A, Oudkerk M. Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. Radiology. 2003 Mar; 226(3):889-96.
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  263. Tiemeier H, Hofman A, van Tuijl HR, Kiliaan AJ, Meijer J, Breteler MM. Inflammatory proteins and depression in the elderly. Epidemiology. 2003 Jan; 14(1):103-7.
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  264. Bornebroek M, Breteler M. Studying risk factors for Parkinson's disease. Eur J Epidemiol. 2003; 18(12):1113-4.
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  265. den Heijer T, Vermeer SE, Clarke R, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MM. Homocysteine and brain atrophy on MRI of non-demented elderly. Brain. 2003 Jan; 126(Pt 1):170-5.
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  266. Engelhart MJ, Geerlings MI, Ruitenberg A, Van Swieten JC, Hofman A, Witteman JC, Breteler MM. Diet and risk of dementia: Does fat matter?: The Rotterdam Study. Neurology. 2002 Dec 24; 59(12):1915-21.
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  267. Tiemeier H, van Tuijl HR, Hofman A, Meijer J, Kiliaan AJ, Breteler MM. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry. 2002 Dec; 159(12):2099-101.
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  268. Prins ND, Den Heijer T, Hofman A, Koudstaal PJ, Jolles J, Clarke R, Breteler MM. Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology. 2002 Nov 12; 59(9):1375-80.
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  269. Maitland-van der Zee AH, Stricker BH, Klungel OH, Kastelein JJ, Hofman A, Witteman JC, Breteler MM, Leufkens HG, van Duijn CM, de Boer A. The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype. Pharmacogenetics. 2002 Nov; 12(8):647-53.
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  270. Hackert VH, den Heijer T, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MM. Hippocampal head size associated with verbal memory performance in nondemented elderly. Neuroimage. 2002 Nov; 17(3):1365-72.
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  271. Tiemeier H, Hofman A, Kiliaan AJ, Meijer J, Breteler MM. Vitamin E and depressive symptoms are not related. The Rotterdam Study. J Affect Disord. 2002 Oct; 72(1):79-83.
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  272. Njajou OT, Hollander M, Koudstaal PJ, Hofman A, Witteman JC, Breteler MM, van Duijn CM. Mutations in the hemochromatosis gene (HFE) and stroke. Stroke. 2002 Oct; 33(10):2363-6.
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  273. den Heijer T, Oudkerk M, Launer LJ, van Duijn CM, Hofman A, Breteler MM. Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes. Neurology. 2002 Sep 10; 59(5):746-8.
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  274. De Groot JC, De Leeuw FE, Oudkerk M, Van Gijn J, Hofman A, Jolles J, Breteler MM. Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann Neurol. 2002 Sep; 52(3):335-41.
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  275. Roks G, Cruts M, Houwing-Duistermaat JJ, Dermaut B, Serneels S, Havekes LM, Hofman A, Breteler MM, Van Broeckhoven C, van Duijn CM. Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study. Am J Med Genet. 2002 Jul 8; 114(5):570-3.
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  276. Tiemeier H, Bakker SL, Hofman A, Koudstaal PJ, Breteler MM. Cerebral haemodynamics and depression in the elderly. J Neurol Neurosurg Psychiatry. 2002 Jul; 73(1):34-9.
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  277. Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC, Breteler MM. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA. 2002 Jun 26; 287(24):3223-9.
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  278. Hollander M, Bots ML, Del Sol AI, Koudstaal PJ, Witteman JC, Grobbee DE, Hofman A, Breteler MM. Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam study. Circulation. 2002 Jun 18; 105(24):2872-7.
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  279. van der Meer IM, de Maat MP, Bots ML, Breteler MM, Meijer J, Kiliaan AJ, Hofman A, Witteman JC. Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study. Arterioscler Thromb Vasc Biol. 2002 May 1; 22(5):838-42.
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  280. de Leeuw FE, de Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J, Breteler MM. Hypertension and cerebral white matter lesions in a prospective cohort study. Brain. 2002 Apr; 125(Pt 4):765-72.
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  281. Vermeer SE, van Dijk EJ, Koudstaal PJ, Oudkerk M, Hofman A, Clarke R, Breteler MM. Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study. Ann Neurol. 2002 Mar; 51(3):285-9.
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  282. Vliegenthart R, Hollander M, Breteler MM, van der Kuip DA, Hofman A, Oudkerk M, Witteman JC. Stroke is associated with coronary calcification as detected by electron-beam CT: the Rotterdam Coronary Calcification Study. Stroke. 2002 Feb; 33(2):462-5.
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  283. Ruitenberg A, van Swieten JC, Witteman JC, Mehta KM, van Duijn CM, Hofman A, Breteler MM. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet. 2002 Jan 26; 359(9303):281-6.
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  284. Degl'Innocenti A, Elmfeldt D, Hansson L, Breteler M, James O, Lithell H, Olofsson B, Skoog I, Trenkwalder P, Zanchetti A, Wiklund I. Cognitive function and health-related quality of life in elderly patients with hypertension--baseline data from the study on cognition and prognosis in the elderly (SCOPE). Blood Press. 2002; 11(3):157-65.
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  285. in 't Veld BA, Launer LJ, Breteler MM, Hofman A, Stricker BH. Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence. Epidemiol Rev. 2002; 24(2):248-68.
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  286. Valente EM, Brancati F, Ferraris A, Graham EA, Davis MB, Breteler MM, Gasser T, Bonifati V, Bentivoglio AR, De Michele G, Dürr A, Cortelli P, Wassilowsky D, Harhangi BS, Rawal N, Caputo V, Filla A, Meco G, Oostra BA, Brice A, Albanese A, Dallapiccola B, Wood NW. PARK6-linked parkinsonism occurs in several European families. Ann Neurol. 2002 Jan; 51(1):14-8.
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  287. Vermeer SE, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM. Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke. 2002 Jan; 33(1):21-5.
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  288. van Dijk EJ, Prins ND, Vermeer SE, Koudstaal PJ, Breteler MM. Frequency of white matter lesions and silent lacunar infarcts. J Neural Transm Suppl. 2002; (62):25-39.
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  289. Salas M, In't Veld BA, van der Linden PD, Hofman A, Breteler M, Stricker BH. Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study. Clin Pharmacol Ther. 2001 Dec; 70(6):561-6.
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  290. Clarke R, Lewington S, Donald A, Johnston C, Refsum H, Stratton I, Jacques P, Breteler MM, Holman R. Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies. J Cardiovasc Risk. 2001 Dec; 8(6):363-9.
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  291. in t' Veld BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T, Breteler MM, Stricker BH. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med. 2001 Nov 22; 345(21):1515-21.
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  292. Dermaut B, Roks G, Theuns J, Rademakers R, Houwing-Duistermaat JJ, Serneels S, Hofman A, Breteler MM, Cruts M, Van Broeckhoven C, van Duijn CM. Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's disease. J Neurol. 2001 Nov; 248(11):935-9.
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  293. Sijens PE, Den Heijer T, De Leeuw FE, De Groot JC, Achten E, Heijboer RJ, Hofman A, Breteler MM, Oudkerk M. Human brain chemical shift imaging at age 60 to 90: analysis of the causes of the observed sex differences in brain metabolites. Invest Radiol. 2001 Oct; 36(10):597-603.
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  294. Hak AE, Pols HA, Stehouwer CD, Meijer J, Kiliaan AJ, Hofman A, Breteler MM, Witteman JC. Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study. J Clin Endocrinol Metab. 2001 Sep; 86(9):4398-405.
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  295. Ruitenberg A, Kalmijn S, de Ridder MA, Redekop WK, van Harskamp F, Hofman A, Launer LJ, Breteler MM. Prognosis of Alzheimer's disease: the Rotterdam Study. Neuroepidemiology. 2001 Aug; 20(3):188-95.
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  296. van de Vijver DA, Stricker BH, Breteler MM, Roos RA, Porsius AJ, de Boer A. Evaluation of antiparkinsonian drugs in pharmacy records as a marker for Parkinson's disease. Pharm World Sci. 2001 Aug; 23(4):148-52.
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  297. Breteler MM. Early life circumstances and late life Alzheimer's disease. Epidemiology. 2001 Jul; 12(4):378-9.
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  298. Ruitenberg A, Ott A, van Swieten JC, Hofman A, Breteler MM. Incidence of dementia: does gender make a difference? Neurobiol Aging. 2001 Jul-Aug; 22(4):575-80.
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  299. del Sol AI, Moons KG, Hollander M, Hofman A, Koudstaal PJ, Grobbee DE, Breteler MM, Witteman JC, Bots ML. Is carotid intima-media thickness useful in cardiovascular disease risk assessment? The Rotterdam Study. Stroke. 2001 Jul; 32(7):1532-8.
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  300. de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM. Cerebral white matter lesions and subjective cognitive dysfunction: the Rotterdam Scan Study. Neurology. 2001 Jun 12; 56(11):1539-45.
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  301. den Heijer T, Launer LJ, de Groot JC, de Leeuw FE, Oudkerk M, van Gijn J, Hofman A, Breteler MM. Serum carotenoids and cerebral white matter lesions: the Rotterdam scan study. J Am Geriatr Soc. 2001 May; 49(5):642-6.
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  302. in't Veld BA, Ruitenberg A, Hofman A, Stricker BH, Breteler MM. Antihypertensive drugs and incidence of dementia: the Rotterdam Study. Neurobiol Aging. 2001 May-Jun; 22(3):407-12.
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  303. Klungel OH, Stricker BH, Breteler MM, Seidell JC, Psaty BM, de Boer A. Is drug treatment of hypertension in clinical practice as effective as in randomized controlled trials with regard to the reduction of the incidence of stroke? Epidemiology. 2001 May; 12(3):339-44.
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  304. Geerlings MI, Ruitenberg A, Witteman JC, van Swieten JC, Hofman A, van Duijn CM, Breteler MM, Launer LJ. Reproductive period and risk of dementia in postmenopausal women. JAMA. 2001 Mar 21; 285(11):1475-81.
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  305. Harhangi BS, Oostra BA, Heutink P, van Duijn CM, Hofman A, Breteler MM. CYP2D6 polymorphism in Parkinson's disease: the Rotterdam Study. Mov Disord. 2001 Mar; 16(2):290-3.
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  306. Vokó Z, Koudstaal PJ, Bots ML, Hofman A, Breteler MM. Aspirin use and risk of stroke in the elderly: the Rotterdam Study. Neuroepidemiology. 2001 Feb; 20(1):40-4.
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  307. de Leeuw FE, de Groot JC, Achten E, Oudkerk M, Ramos LM, Heijboer R, Hofman A, Jolles J, van Gijn J, Breteler MM. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry. 2001 Jan; 70(1):9-14.
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  308. Sijens PE, den Heijer T, de Leeuw FE, de Groot JC, Achten E, Heijboer RJ, Hofman A, Breteler MM, Oudkerk M. MR spectroscopy detection of lactate and lipid signals in the brains of healthy elderly people. Eur Radiol. 2001; 11(8):1495-501.
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  309. Ruitenberg A, Skoog I, Ott A, Aevarsson O, Witteman JC, Lernfelt B, van Harskamp F, Hofman A, Breteler MM. Blood pressure and risk of dementia: results from the Rotterdam study and the Gothenburg H-70 Study. Dement Geriatr Cogn Disord. 2001 Jan-Feb; 12(1):33-9.
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  310. McDonnell J, Redekop WK, van der Roer N, Goes E, Ruitenberg A, Busschbach JJ, Breteler MM, Rutten FF. The cost of treatment of Alzheimer's disease in The Netherlands: a regression-based simulation model. Pharmacoeconomics. 2001; 19(4):379-90.
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  311. Kalmijn S, Janssen JA, Pols HA, Lamberts SW, Breteler MM. A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly. J Clin Endocrinol Metab. 2000 Dec; 85(12):4551-5.
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  312. Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM. Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clin Endocrinol (Oxf). 2000 Dec; 53(6):733-7.
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  313. de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM. Cerebral white matter lesions and depressive symptoms in elderly adults. Arch Gen Psychiatry. 2000 Nov; 57(11):1071-6.
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  314. Elbaz A, Manubens-Bertran JM, Baldereschi M, Breteler MM, Grigoletto F, Lopez-Pousa S, Dartigues JF, Alpérovitch A, Rocca WA, Tzourio C. Parkinson's disease, smoking, and family history. EUROPARKINSON Study Group. J Neurol. 2000 Oct; 247(10):793-8.
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  315. Koster MN, Dermaut B, Cruts M, Houwing-Duistermaat JJ, Roks G, Tol J, Ott A, Hofman A, Munteanu G, Breteler MM, van Duijn CM, Van Broeckhoven C. The alpha2-macroglobulin gene in AD: a population-based study and meta-analysis. Neurology. 2000 Sep 12; 55(5):678-84.
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  316. Klungel OH, Stricker BH, Breteler MM, Seidell JC, de Boer A. [Undertreatment of hypertension and the risk of stroke in the oldest old]. Tijdschr Gerontol Geriatr. 2000 Jun; 31(3):119-22.
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  317. de Leeuw FE, de Groot JC, Oudkerk M, Kors JA, Hofman A, van Gijn J, Breteler MM. Atrial fibrillation and the risk of cerebral white matter lesions. Neurology. 2000 May 9; 54(9):1795-801.
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  318. Launer LJ, Oudkerk M, Nilsson LG, Alperovitch A, Berger K, Breteler MM, Fuhrer R, Giampaoli S, Nissinen A, Pajak A, Sans S, Schmidt R, Hofman A. CASCADE: a European collaborative study on vascular determinants of brain lesions. Study design and objectives. Neuroepidemiology. 2000 May-Jun; 19(3):113-20.
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  319. Breteler MM. Vascular involvement in cognitive decline and dementia. Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study. Ann N Y Acad Sci. 2000 Apr; 903:457-65.
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  320. de Leeuw FE, de Groot JC, Bots ML, Witteman JC, Oudkerk M, Hofman A, van Gijn J, Breteler MM. Carotid atherosclerosis and cerebral white matter lesions in a population based magnetic resonance imaging study. J Neurol. 2000 Apr; 247(4):291-6.
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  321. Harhangi BS, de Rijk MC, van Duijn CM, Van Broeckhoven C, Hofman A, Breteler MM. APOE and the risk of PD with or without dementia in a population-based study. Neurology. 2000 Mar 28; 54(6):1272-6.
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  322. Breteler MM. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol Aging. 2000 Mar-Apr; 21(2):153-60.
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  323. Bakker SL, de Leeuw FE, Koudstaal PJ, Hofman A, Breteler MM. Cerebral CO2 reactivity, cholesterol, and high-density lipoprotein cholesterol in the elderly. Neurology. 2000 Feb 22; 54(4):987-9.
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  324. de Leeuw FE, De Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J, Breteler MM. Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly. Stroke. 2000 Feb; 31(2):425-9.
    View in: PubMed
  325. de Groot JC, de Leeuw FE, Oudkerk M, van Gijn J, Hofman A, Jolles J, Breteler MM. Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann Neurol. 2000 Feb; 47(2):145-51.
    View in: PubMed
  326. de Rijk MC, Launer LJ, Berger K, Breteler MM, Dartigues JF, Baldereschi M, Fratiglioni L, Lobo A, Martinez-Lage J, Trenkwalder C, Hofman A. Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000; 54(11 Suppl 5):S21-3.
    View in: PubMed
  327. Hansson L, Lithell H, Skoog I, Baro F, Bánki CM, Breteler M, Castaigne A, Correia M, Degaute JP, Elmfeldt D, Engedal K, Farsang C, Ferro J, Hachinski V, Hofman A, James OF, Krisin E, Leeman M, de Leeuw PW, Leys D, Lobo A, Nordby G, Olofsson B, Opolski G, Prince M, Reischies FM. Study on COgnition and Prognosis in the Elderly (SCOPE): baseline characteristics. Blood Press. 2000; 9(2-3):146-51.
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  328. Schmidt R, Breteler MM, Inzitari D, Fratiglioni L, Hofman A, Launer LJ. Prognosis with stroke in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000; 54(11 Suppl 5):S34-7.
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  329. Jagger C, Andersen K, Breteler MM, Copeland JR, Helmer C, Baldereschi M, Fratiglioni L, Lobo A, Soininen H, Hofman A, Launer LJ. Prognosis with dementia in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000; 54(11 Suppl 5):S16-20.
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  330. Di Carlo A, Launer LJ, Breteler MM, Fratiglioni L, Lobo A, Martinez-Lage J, Schmidt R, Hofman A. Frequency of stroke in Europe: A collaborative study of population-based cohorts. ILSA Working Group and the Neurologic Diseases in the Elderly Research Group. Italian Longitudinal Study on Aging. Neurology. 2000; 54(11 Suppl 5):S28-33.
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  331. Berger K, Breteler MM, Helmer C, Inzitari D, Fratiglioni L, Trenkwalder C, Hofman A, Launer LJ. Prognosis with Parkinson's disease in europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000; 54(11 Suppl 5):S24-7.
    View in: PubMed
  332. Fratiglioni L, Launer LJ, Andersen K, Breteler MM, Copeland JR, Dartigues JF, Lobo A, Martinez-Lage J, Soininen H, Hofman A. Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000; 54(11 Suppl 5):S10-5.
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  333. Lobo A, Launer LJ, Fratiglioni L, Andersen K, Di Carlo A, Breteler MM, Copeland JR, Dartigues JF, Jagger C, Martinez-Lage J, Soininen H, Hofman A. Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology. 2000; 54(11 Suppl 5):S4-9.
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  334. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology. 1999 Dec 10; 53(9):1937-42.
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  335. Mehta KM, Ott A, Kalmijn S, Slooter AJ, van Duijn CM, Hofman A, Breteler MM. Head trauma and risk of dementia and Alzheimer's disease: The Rotterdam Study. Neurology. 1999 Dec 10; 53(9):1959-62.
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  336. Vokó Z, Bots ML, Hofman A, Koudstaal PJ, Witteman JC, Breteler MM. J-shaped relation between blood pressure and stroke in treated hypertensives. Hypertension. 1999 Dec; 34(6):1181-5.
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  337. de Leeuw FE, de Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J, Breteler MM. A follow-up study of blood pressure and cerebral white matter lesions. Ann Neurol. 1999 Dec; 46(6):827-33.
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  338. Baker FM, Launer LJ, Breteler MM, Hofman A. Ommoord district residents: prevalence and treatment of depression. Int Psychogeriatr. 1999 Dec; 11(4):385-97.
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  339. Klaver CC, Ott A, Hofman A, Assink JJ, Breteler MM, de Jong PT. Is age-related maculopathy associated with Alzheimer's Disease? The Rotterdam Study. Am J Epidemiol. 1999 Nov 1; 150(9):963-8.
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  340. Slooter AJ, Cruts M, Ott A, Bots ML, Witteman JC, Hofman A, Van Broeckhoven C, Breteler MM, van Duijn CM. The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study. Neurology. 1999 Oct 22; 53(7):1593-5.
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  341. Harhangi BS, Oostra BA, Heutink P, van Duijn CM, Hofman A, Breteler MM. N-acetyltransferase-2 polymorphism in Parkinson's disease: the Rotterdam study. J Neurol Neurosurg Psychiatry. 1999 Oct; 67(4):518-20.
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  342. Skoog I, Kalaria RN, Breteler MM. Vascular factors and Alzheimer disease. Alzheimer Dis Assoc Disord. 1999 Oct-Dec; 13 Suppl 3:S106-14.
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  343. Kalmijn S, Launer LJ, Lindemans J, Bots ML, Hofman A, Breteler MM. Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. Am J Epidemiol. 1999 Aug 1; 150(3):283-9.
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  344. Harhangi BS, Farrer MJ, Lincoln S, Bonifati V, Meco G, De Michele G, Brice A, Dürr A, Martinez M, Gasser T, Bereznai B, Vaughan JR, Wood NW, Hardy J, Oostra BA, Breteler MM. The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease. Neurosci Lett. 1999 Jul 23; 270(1):1-4.
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  345. Klungel OH, Stricker BH, Paes AH, Seidell JC, Bakker A, Voko Z, Breteler MM. Excess stroke among hypertensive men and women attributable to undertreatment of hypertension. Stroke. 1999 Jul; 30(7):1312-8.
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  346. Sijens PE, Oudkerk M, de Leeuw FE, de Groot JC, Achten E, Heijboer R, Hofman A, Breteler MM. 1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men. Magn Reson Med. 1999 Jul; 42(1):24-31.
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  347. Witthaus E, Ott A, Barendregt JJ, Breteler M, Bonneux L. Burden of mortality and morbidity from dementia. Alzheimer Dis Assoc Disord. 1999 Jul-Sep; 13(3):176-81.
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  348. Elbaz A, Grigoletto F, Baldereschi M, Breteler MM, Manubens-Bertran JM, Lopez-Pousa S, Dartigues JF, Alpérovitch A, Tzourio C, Rocca WA. Familial aggregation of Parkinson's disease: a population-based case-control study in Europe. EUROPARKINSON Study Group. Neurology. 1999 Jun 10; 52(9):1876-82.
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  349. Slooter AJ, Houwing-Duistermaat JJ, van Harskamp F, Cruts M, Van Broeckhoven C, Breteler MM, Hofman A, Stijnen T, van Duijn CM. Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study. J Neurol. 1999 Apr; 246(4):304-8.
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  350. Ott A, van Rossum CT, van Harskamp F, van de Mheen H, Hofman A, Breteler MM. Education and the incidence of dementia in a large population-based study: the Rotterdam Study. Neurology. 1999 Feb; 52(3):663-6.
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  351. van Rossum CT, van de Mheen H, Breteler MM, Grobbee DE, Mackenbach JP. Socioeconomic differences in stroke among Dutch elderly women: the Rotterdam Study. Stroke. 1999 Feb; 30(2):357-62.
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  352. Bakker SL, de Leeuw FE, de Groot JC, Hofman A, Koudstaal PJ, Breteler MM. Cerebral vasomotor reactivity and cerebral white matter lesions in the elderly. Neurology. 1999 Feb; 52(3):578-83.
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  353. Hansson L, Lithell H, Skoog I, Baro F, Bánki CM, Breteler M, Carbonin PU, Castaigne A, Correia M, Degaute JP, Elmfeldt D, Engedal K, Farsang C, Ferro J, Hachinski V, Hofman A, James OF, Krisin E, Leeman M, de Leeuw PW, Leys D, Lobo A, Nordby G, Olofsson B, Zanchetti A, et al. Study on COgnition and Prognosis in the Elderly (SCOPE). Blood Press. 1999; 8(3):177-83.
    View in: PubMed
  354. Dermaut B, Cruts M, Slooter AJ, Van Gestel S, De Jonghe C, Vanderstichele H, Vanmechelen E, Breteler MM, Hofman A, van Duijn CM, Van Broeckhoven C. The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease. Am J Hum Genet. 1999 Jan; 64(1):290-2.
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  355. Buijs PC, Krabbe-Hartkamp MJ, Bakker CJ, de Lange EE, Ramos LM, Breteler MM, Mali WP. Effect of age on cerebral blood flow: measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults. Radiology. 1998 Dec; 209(3):667-74.
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  356. in 't Veld BA, Launer LJ, Hoes AW, Ott A, Hofman A, Breteler MM, Stricker BH. NSAIDs and incident Alzheimer's disease. The Rotterdam Study. Neurobiol Aging. 1998 Nov-Dec; 19(6):607-11.
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  357. Kalmijn S, Launer LJ, Stolk RP, de Jong FH, Pols HA, Hofman A, Breteler MM, Lamberts SW. A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly. J Clin Endocrinol Metab. 1998 Oct; 83(10):3487-92.
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  358. Vaughan J, Durr A, Tassin J, Bereznai B, Gasser T, Bonifati V, De Michele G, Fabrizio E, Volpe G, Bandmann O, Johnson WG, Golbe LI, Breteler M, Meco G, Agid Y, Brice A, Marsden CD, Wood NW. The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease. Ann Neurol. 1998 Aug; 44(2):270-3.
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  359. Slooter AJ, Cruts M, Kalmijn S, Hofman A, Breteler MM, Van Broeckhoven C, van Duijn CM. Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Arch Neurol. 1998 Jul; 55(7):964-8.
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  360. Anderson DW, Rocca WA, de Rijk MC, Grigoletto F, Melcon MO, Breteler MM, Maraganore DM. Case ascertainment uncertainties in prevalence surveys of Parkinson's disease. Mov Disord. 1998 Jul; 13(4):626-32.
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  361. Ott A, Slooter AJ, Hofman A, van Harskamp F, Witteman JC, Van Broeckhoven C, van Duijn CM, Breteler MM. Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study. Lancet. 1998 Jun 20; 351(9119):1840-3.
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  362. Slooter AJ, de Knijff P, Hofman A, Cruts M, Breteler MM, Van Broeckhoven C, Havekes LM, van Duijn CM. Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam study. Neurosci Lett. 1998 May 22; 248(1):21-4.
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  363. Breteler MM, Ott A, Hofman A. The new epidemic: frequency of dementia in the Rotterdam Study. Haemostasis. 1998 May-Aug; 28(3-4):117-23.
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  364. Bots ML, Breteler MM, van Kooten F, Haverkate F, Meijer P, Koudstaal PJ, Grobbee DE, Kluft C. Coagulation and fibrinolysis markers and risk of dementia. The Dutch Vascular Factors in Dementia Study. Haemostasis. 1998 May-Aug; 28(3-4):216-22.
    View in: PubMed
  365. Breteler MM, Bots ML, Ott A, Hofman A. Risk factors for vascular disease and dementia. Haemostasis. 1998 May-Aug; 28(3-4):167-73.
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  366. Bots ML, van Kooten F, Breteler MM, Slagboom PE, Hofman A, Haverkate F, Meijer P, Koudstaal PJ, Grobbee DE, Kluft C. Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study. Haemostasis. 1998 May-Aug; 28(3-4):209-15.
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  367. Claus JJ, de Koning I, van Harskamp F, Breteler MM, Voet B, Gutzmann H, Dahlke F, van der Cammen T, Hofman A. Lisuride treatment of Alzheimer's disease. A preliminary placebo-controlled clinical trial of safety and therapeutic efficacy. Clin Neuropharmacol. 1998 May-Jun; 21(3):190-5.
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  368. Fahim S, van Duijn CM, Baker FM, Launer L, Breteler MM, Schudel WJ, Hofman A. A study of familial aggregation of depression, dementia and Parkinson's disease. Eur J Epidemiol. 1998 Apr; 14(3):233-8.
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  369. Krabbe-Hartkamp MJ, van der Grond J, de Leeuw FE, de Groot JC, Algra A, Hillen B, Breteler MM, Mali WP. Circle of Willis: morphologic variation on three-dimensional time-of-flight MR angiograms. Radiology. 1998 Apr; 207(1):103-11.
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  370. Ott A, Breteler MM, van Harskamp F, Stijnen T, Hofman A. Incidence and risk of dementia. The Rotterdam Study. Am J Epidemiol. 1998 Mar 15; 147(6):574-80.
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  371. van Kooten F, Bots ML, Breteler MM, Haverkate F, van Swieten JC, Grobbee DE, Koudstaal PJ, Kluft C. The Dutch Vascular Factors in Dementia Study: rationale and design. J Neurol. 1998 Jan; 245(1):32-9.
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  372. de Groot JC, de Leeuw FE, Breteler MM. Cognitive correlates of cerebral white matter changes. J Neural Transm Suppl. 1998; 53:41-67.
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  373. Claus JJ, Breteler MM, Hasan D, Krenning EP, Bots ML, Grobbee DE, Van Swieten JC, Van Harskamp F, Hofman A. Regional cerebral blood flow and cerebrovascular risk factors in the elderly population. Neurobiol Aging. 1998 Jan-Feb; 19(1):57-64.
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  374. Tzourio C, Rocca WA, Breteler MM, Baldereschi M, Dartigues JF, Lopez-Pousa S, Manubens-Bertran JM, Alpérovitch A. Smoking and Parkinson's disease. An age-dependent risk effect? The EUROPARKINSON Study Group. Neurology. 1997 Nov; 49(5):1267-72.
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  375. Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol. 1997 Nov; 42(5):776-82.
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  376. Li X, Breteler MM, de Bruyne MC, Meinardi H, Hauser WA, Hofman A. Vascular determinants of epilepsy: the Rotterdam Study. Epilepsia. 1997 Nov; 38(11):1216-20.
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  377. de Rijk MC, Breteler MM, den Breeijen JH, Launer LJ, Grobbee DE, van der Meché FG, Hofman A. Dietary antioxidants and Parkinson disease. The Rotterdam Study. Arch Neurol. 1997 Jun; 54(6):762-5.
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  378. de Rijk MC, Rocca WA, Anderson DW, Melcon MO, Breteler MM, Maraganore DM. A population perspective on diagnostic criteria for Parkinson's disease. Neurology. 1997 May; 48(5):1277-81.
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  379. Stolk RP, Breteler MM, Ott A, Pols HA, Lamberts SW, Grobbee DE, Hofman A. Insulin and cognitive function in an elderly population. The Rotterdam Study. Diabetes Care. 1997 May; 20(5):792-5.
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  380. Slooter AJ, Tang MX, van Duijn CM, Stern Y, Ott A, Bell K, Breteler MM, Van Broeckhoven C, Tatemichi TK, Tycko B, Hofman A, Mayeux R. Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. JAMA. 1997 Mar 12; 277(10):818-21.
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  381. Launer LJ, Jama JW, Ott A, Breteler MM, Hoes AW, Hofman A. Histamine H2 blocking drugs and the risk for Alzheimer's disease: the Rotterdam Study. Neurobiol Aging. 1997 Mar-Apr; 18(2):257-9.
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  382. Ott A, Breteler MM, de Bruyne MC, van Harskamp F, Grobbee DE, Hofman A. Atrial fibrillation and dementia in a population-based study. The Rotterdam Study. Stroke. 1997 Feb; 28(2):316-21.
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  383. Hofman A, Ott A, Breteler MM, Bots ML, Slooter AJ, van Harskamp F, van Duijn CN, Van Broeckhoven C, Grobbee DE. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet. 1997 Jan 18; 349(9046):151-4.
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  384. de Rijk MC, Tzourio C, Breteler MM, Dartigues JF, Amaducci L, Lopez-Pousa S, Manubens-Bertran JM, Alpérovitch A, Rocca WA. Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease. J Neurol Neurosurg Psychiatry. 1997 Jan; 62(1):10-5.
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  385. Perenboom RJ, Boshuizen HC, Breteler MM, Ott A, Van de Water HP. Dementia-free life expectancy (DemFLE) in The Netherlands. Soc Sci Med. 1996 Dec; 43(12):1703-7.
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  386. Ott A, Stolk RP, Hofman A, van Harskamp F, Grobbee DE, Breteler MM. Association of diabetes mellitus and dementia: the Rotterdam Study. Diabetologia. 1996 Nov; 39(11):1392-7.
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  387. Jama JW, Launer LJ, Witteman JC, den Breeijen JH, Breteler MM, Grobbee DE, Hofman A. Dietary antioxidants and cognitive function in a population-based sample of older persons. The Rotterdam Study. Am J Epidemiol. 1996 Aug 1; 144(3):275-80.
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  388. Claus JJ, Breteler MM, Hasan D, Krenning EP, Bots ML, Grobbee DE, van Swieten JC, van Harskamp F, Hofman A. Vascular risk factors, atherosclerosis, cerebral white matter lesions and cerebral perfusion in a population-based study. Eur J Nucl Med. 1996 Jun; 23(6):675-82.
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  389. de la Court A, Breteler MM, Meinardi H, Hauser WA, Hofman A. Prevalence of epilepsy in the elderly: the Rotterdam Study. Epilepsia. 1996 Feb; 37(2):141-7.
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  390. Breteler MM, de Groot RR, van Romunde LK, Hofman A. Risk of dementia in patients with Parkinson's disease, epilepsy, and severe head trauma: a register-based follow-up study. Am J Epidemiol. 1995 Dec 15; 142(12):1300-5.
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  391. de Rijk MC, Breteler MM, Graveland GA, Ott A, Grobbee DE, van der Meché FG, Hofman A. Prevalence of Parkinson's disease in the elderly: the Rotterdam Study. Neurology. 1995 Dec; 45(12):2143-6.
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  392. Andersen K, Launer LJ, Ott A, Hoes AW, Breteler MM, Hofman A. Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study. Neurology. 1995 Aug; 45(8):1441-5.
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  393. Ott A, Breteler MM, van Harskamp F, Claus JJ, van der Cammen TJ, Grobbee DE, Hofman A. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ. 1995 Apr 15; 310(6985):970-3.
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  394. Claus JJ, van Harskamp F, Breteler MM, Krenning EP, van der Cammen TJ, Hofman A, Hasan D. Assessment of cerebral perfusion with single-photon emission tomography in normal subjects and in patients with Alzheimer's disease: effects of region of interest selection. Eur J Nucl Med. 1994 Oct; 21(10):1044-51.
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  395. Breteler MM, van Swieten JC, Bots ML, Grobbee DE, Claus JJ, van den Hout JH, van Harskamp F, Tanghe HL, de Jong PT, van Gijn J, et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology. 1994 Jul; 44(7):1246-52.
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  396. Breteler MM, Claus JJ, Grobbee DE, Hofman A. Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam Study. BMJ. 1994 Jun 18; 308(6944):1604-8.
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  397. Breteler MM, van Amerongen NM, van Swieten JC, Claus JJ, Grobbee DE, van Gijn J, Hofman A, van Harskamp F. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study. Stroke. 1994 Jun; 25(6):1109-15.
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  398. Claus JJ, van Harskamp F, Breteler MM, Krenning EP, de Koning I, van der Cammen TJ, Hofman A, Hasan D. The diagnostic value of SPECT with Tc 99m HMPAO in Alzheimer's disease: a population-based study. Neurology. 1994 Mar; 44(3 Pt 1):454-61.
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  399. Bots ML, van Swieten JC, Breteler MM, de Jong PT, van Gijn J, Hofman A, Grobbee DE. Cerebral white matter lesions and atherosclerosis in the Rotterdam Study. Lancet. 1993 May 15; 341(8855):1232-7.
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  400. Breteler MM, van den Ouweland FA, Grobbee DE, Hofman A. A community-based study of dementia: the Rotterdam Elderly Study. Neuroepidemiology. 1992; 11 Suppl 1:23-8.
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  401. Breteler MM, Claus JJ, van Duijn CM, Launer LJ, Hofman A. Epidemiology of Alzheimer's disease. Epidemiol Rev. 1992; 14:59-82.
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  402. Launer LJ, Brayne C, Breteler MM. Epidemiologic approach to the study of dementing diseases: a nested case-control study in European incidence studies of dementia. Neuroepidemiology. 1992; 11 Suppl 1:114-8.
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  403. Rocca WA, Hofman A, Brayne C, Breteler MM, Clarke M, Copeland JR, Dartigues JF, Engedal K, Hagnell O, Heeren TJ, et al. The prevalence of vascular dementia in Europe: facts and fragments from 1980-1990 studies. EURODEM-Prevalence Research Group. Ann Neurol. 1991 Dec; 30(6):817-24.
    View in: PubMed
  404. Hofman A, Rocca WA, Brayne C, Breteler MM, Clarke M, Cooper B, Copeland JR, Dartigues JF, da Silva Droux A, Hagnell O, et al. The prevalence of dementia in Europe: a collaborative study of 1980-1990 findings. Eurodem Prevalence Research Group. Int J Epidemiol. 1991 Sep; 20(3):736-48.
    View in: PubMed
  405. Rocca WA, Hofman A, Brayne C, Breteler MM, Clarke M, Copeland JR, Dartigues JF, Engedal K, Hagnell O, Heeren TJ, et al. Frequency and distribution of Alzheimer's disease in Europe: a collaborative study of 1980-1990 prevalence findings. The EURODEM-Prevalence Research Group. Ann Neurol. 1991 Sep; 30(3):381-90.
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  406. Breteler MM, van Duijn CM, Chandra V, Fratiglioni L, Graves AB, Heyman A, Jorm AF, Kokmen E, Kondo K, Mortimer JA, et al. Medical history and the risk of Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol. 1991; 20 Suppl 2:S36-42.
    View in: PubMed
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