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Last Name
Institution

Eng H. Lo, PH.D.

TitleProfessor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMass. General Hospital-East
Room 2401
149 13th Street
Charlestown MA 02129
Phone617/726-4043
Fax617/726-7830

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lauer A, Pfeilschifter W, Schaffer CB, Lo EH, Foerch C. Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies. Lancet Neurol. 2013 Apr; 12(4):394-405.
    View in: PubMed
  2. Dapul HR, Park J, Zhang J, Lee C, Daneshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive Injury before or after Controlled Cortical Impact Exacerbates Histopathology and Functional Outcome in a Mixed Traumatic Brain Injury Model in Mice. J Neurotrauma. 2013 Mar 1; 30(5):382-91.
    View in: PubMed
  3. Fan X, Lo EH, Wang X. Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats. Stroke. 2013 Mar; 44(3):745-52.
    View in: PubMed
  4. Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice. PLoS One. 2013; 8(2):e54203.
    View in: PubMed
  5. Campos F, Qin T, Castillo J, Seo JH, Arai K, Lo EH, Waeber C. Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke. 2013 Feb; 44(2):505-11.
    View in: PubMed
  6. Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH. The vasculome of the mouse brain. PLoS One. 2012; 7(12):e52665.
    View in: PubMed
  7. Lopez MF, Sarracino DA, Vogelsang M, Sutton JN, Athanas M, Krastins B, Garces A, Prakash A, Peterman S, Demirjian Z, Inglessis-Azuaje I, Feeney K, Elia M, McMullin D, William Dec G, Palacios I, Lo EH, Buonanno F, Ning M. Heart-brain signaling in patent foramen ovale-related stroke: differential plasma proteomic expression patterns revealed with a 2-pass liquid chromatography-tandem mass spectrometry discovery workflow. J Investig Med. 2012 Dec; 60(8):1122-30.
    View in: PubMed
  8. Ning M, Lopez M, Cao J, Buonanno FS, Lo EH. Application of proteomics to cerebrovascular disease. Electrophoresis. 2012 Dec; 33(24):3582-97.
    View in: PubMed
  9. Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum JL, Montaner J, Holman TR, Lo EH, van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol. 2013 Jan; 73(1):129-35.
    View in: PubMed
  10. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Wee HJ, Cha JH, Park JH, Lee HS, Lee HJ, Jung H, Park ZY, Park SH, Han BW, Seo JH, Lo EH, Kim KW. The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity. Biochem Biophys Res Commun. 2012 Nov 30; 428(4):438-44.
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  11. Fan X, Ning M, Lo EH, Wang X. Early Insulin Glycemic Control Combined With tPA Thrombolysis Reduces Acute Brain Tissue Damages in a Focal Embolic Stroke Model of Diabetic Rats. Stroke. 2013 Jan; 44(1):255-9.
    View in: PubMed
  12. Guo S, Som AT, Waeber C, Lo EH. Vascular neuroprotection via TrkB- and Akt-dependent cell survival signaling. J Neurochem. 2012 Nov; 123 Suppl 2:58-64.
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  13. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013 Feb; 27(2):437-45.
    View in: PubMed
  14. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, Li G, Ren C, Luo Y, Ling F, Jia J, Hua Y, Wang X, Ding Y, Lo EH, Ji X. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012 Oct 30; 79(18):1853-61.
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  15. Chou SH, Feske SK, Atherton J, Konigsberg RG, De Jager PL, Du R, Ogilvy CS, Lo EH, Ning M. Early elevation of serum tumor necrosis factor-a is associated with poor outcome in subarachnoid hemorrhage. J Investig Med. 2012 Oct; 60(7):1054-8.
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  16. Goergen CJ, Radhakrishnan H, Sakadžic S, Mandeville ET, Lo EH, Sosnovik DE, Srinivasan VJ. Optical coherence tractography using intrinsic contrast. Opt Lett. 2012 Sep 15; 37(18):3882-4.
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  17. Tjärnlund-Wolf A, Brogren H, Lo EH, Wang X. Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases. Stroke. 2012 Oct; 43(10):2833-9.
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  18. Cheung JS, Wang E, Lo EH, Sun PZ. Stratification of heterogeneous diffusion MRI ischemic lesion with kurtosis imaging: evaluation of mean diffusion and kurtosis MRI mismatch in an animal model of transient focal ischemia. Stroke. 2012 Aug; 43(8):2252-4.
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  19. Xing C, Arai K, Lo EH, Hommel M. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 2012 Jul; 7(5):378-85.
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  20. Wu O, Lu J, Mandeville JB, Murata Y, Egi Y, Dai G, Marota JJ, Diwan I, Dijkhuizen RM, Kwong KK, Lo EH, Singhal AB. Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke. J Cereb Blood Flow Metab. 2012 Sep; 32(9):1800-9.
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  21. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012; 13:67.
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  22. Murata Y, Fujiwara N, Seo JH, Yan F, Liu X, Terasaki Y, Luo Y, Arai K, Ji X, Lo EH. Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia. J Neurosci. 2012 Jun 13; 32(24):8112-5.
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  23. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30.
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  24. Hayakawa K, Pham LD, Katusic ZS, Arai K, Lo EH. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012 May 8; 109(19):7505-10.
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  25. Lok J, Zhao S, Leung W, Seo JH, Navaratna D, Wang X, Whalen MJ, Lo EH. Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury. Transl Stroke Res. 2012 Jul 1; 3(S1):S119-S124.
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  26. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH. Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab. 2012 Jun; 32(6):983-8.
    View in: PubMed
  27. Lopez MF, Sarracino DA, Prakash A, Athanas M, Krastins B, Rezai T, Sutton JN, Peterman S, Gvozdyak O, Chou S, Lo E, Buonanno F, Ning M. Discrimination of ischemic and hemorrhagic strokes using a multiplexed, mass spectrometry-based assay for serum apolipoproteins coupled to multi-marker ROC algorithm. Proteomics Clin Appl. 2012 Apr; 6(3-4):190-200.
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  28. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, Guo S, Kim KW, Lo EH, Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81.
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  29. Foerch C, You Z, Wang H, Lo EH, Whalen MJ. Traumatic brain injury during warfarin anticoagulation: an experimental study in mice. J Neurotrauma. 2012 Apr 10; 29(6):1150-5.
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  30. Srinivasan VJ, Radhakrishnan H, Lo EH, Mandeville ET, Jiang JY, Barry S, Cable AE. OCT methods for capillary velocimetry. Biomed Opt Express. 2012 Mar 1; 3(3):612-29.
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  31. Hayakawa K, Seo JH, Pham LD, Miyamoto N, Som AT, Guo S, Kim KW, Lo EH, Arai K. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6.
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  32. Simão F, Pagnussat AS, Seo JH, Navaratna D, Leung W, Lok J, Guo S, Waeber C, Salbego CG, Lo EH. Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases. J Cereb Blood Flow Metab. 2012 May; 32(5):884-95.
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  33. Meng R, Konakondla S, Wang X, Lo EH, Ding Y, Ji X. Plasma biomarker may help to distinguish acute CVST from non-thrombotic CVSS in emergency. Int J Stroke. 2012 Feb; 7(2):183-4.
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  34. Lo EH. Biphasic inflammatory responses in injury and repair after stroke. Rinsho Shinkeigaku. 2012; 52(11):913.
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  35. Seo JH, Guo S, Lok J, Navaratna D, Whalen MJ, Kim KW, Lo EH. Neurovascular matrix metalloproteinases and the blood-brain barrier. Curr Pharm Des. 2012; 18(25):3645-8.
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  36. Mbye LH, Keles E, Tao L, Zhang J, Chung J, Larvie M, Koppula R, Lo EH, Whalen MJ. Kollidon VA64, a membrane-resealing agent, reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2012 Mar; 32(3):515-24.
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  37. Zhu X, Tao L, Tejima-Mandeville E, Qiu J, Park J, Garber K, Ericsson M, Lo EH, Whalen MJ. Plasmalemma permeability and necrotic cell death phenotypes after intracerebral hemorrhage in mice. Stroke. 2012 Feb; 43(2):524-31.
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  38. Fan X, Qiu J, Yu Z, Dai H, Singhal AB, Lo EH, Wang X. A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke. 2012 Feb; 43(2):567-70.
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  39. Schlunk F, Van Cott EM, Hayakawa K, Pfeilschifter W, Lo EH, Foerch C. Recombinant activated coagulation factor VII and prothrombin complex concentrates are equally effective in reducing hematoma volume in experimental warfarin-associated intracerebral hemorrhage. Stroke. 2012 Jan; 43(1):246-9.
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  40. Ding MC, Wang Q, Lo EH, Stanley GB. Cortical excitation and inhibition following focal traumatic brain injury. J Neurosci. 2011 Oct 5; 31(40):14085-94.
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  41. Wei X, Yu Z, Cho KS, Chen H, Malik MT, Chen X, Lo EH, Wang X, Chen DF. Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage. Am J Pathol. 2011 Dec; 179(6):2788-97.
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  42. Chou SH, Lee PS, Konigsberg RG, Gallacci D, Chiou T, Arai K, Simmons S, Bauer D, Feske SK, Lo EH, Ning M. Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage. Stroke. 2011 Dec; 42(12):3624-7.
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  43. Park J, Zhang J, Qiu J, Zhu X, Degterev A, Lo EH, Whalen MJ. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):330-40.
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  44. Lauer A, Cianchetti FA, Van Cott EM, Schlunk F, Schulz E, Pfeilschifter W, Steinmetz H, Schaffer CB, Lo EH, Foerch C. Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage. Circulation. 2011 Oct 11; 124(15):1654-62.
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  45. Hayakawa K, Pham LD, Som AT, Lee BJ, Guo S, Lo EH, Arai K. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70.
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  46. Cheung JS, Wang E, Zhang X, Mandeville E, Lo EH, Sorensen AG, Sun PZ. Fast radio-frequency enforced steady state (FRESS) spin echo MRI for quantitative T2 mapping: minimizing the apparent repetition time (TR) dependence for fast T2 measurement. NMR Biomed. 2012 Feb; 25(2):189-94.
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  47. Kahle KT, Walcott BP, Nahed BV, Barnard ZR, Lo EH, Buonanno FS, Venna N, Ning M. Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection. J Clin Neurosci. 2011 Sep; 18(9):1245-8.
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  48. Lok J, Leung W, Zhao S, Pallast S, van Leyen K, Guo S, Wang X, Yalcin A, Lo EH. ?-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma. J Neurochem. 2011 Jul; 118(2):248-55.
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  49. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8.
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  50. Navaratna D, Guo SZ, Hayakawa K, Wang X, Gerhardinger C, Lo EH. Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain. Diabetes. 2011 Jun; 60(6):1789-96.
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  51. Caplan LR, Arenillas J, Cramer SC, Joutel A, Lo EH, Meschia J, Savitz S, Tournier-Lasserve E. Stroke-related translational research. Arch Neurol. 2011 Sep; 68(9):1110-23.
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  52. Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. J Vis Exp. 2011; (51).
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  53. Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH. Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke. 2011 May; 42(5):1469-72.
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  54. Sun PZ, Cheung JS, Wang E, Lo EH. Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Aug; 31(8):1743-50.
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  55. Lauer A, Schlunk F, Van Cott EM, Steinmetz H, Lo EH, Foerch C. Antiplatelet pretreatment does not increase hematoma volume in experimental intracerebral hemorrhage. J Cereb Blood Flow Metab. 2011 Aug; 31(8):1736-42.
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  56. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5.
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  57. Lok J, Leung W, Murphy S, Butler W, Noviski N, Lo EH. Intracranial hemorrhage: mechanisms of secondary brain injury. Acta Neurochir Suppl. 2011; 111:63-9.
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  58. Ning M, Sarracino DA, Kho AT, Guo S, Lee SR, Krastins B, Buonanno FS, Vizcaíno JA, Orchard S, McMullin D, Wang X, Lo EH. Proteomic temporal profile of human brain endothelium after oxidative stress. Stroke. 2011 Jan; 42(1):37-43.
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  59. Ning M, Sarracino DA, Buonanno FS, Krastins B, Chou S, McMullin D, Wang X, Lopez M, Lo EH. Proteomic Protease Substrate Profiling of tPA Treatment in Acute Ischemic Stroke Patients: A Step Toward Individualizing Thrombolytic Therapy at the Bedside. Transl Stroke Res. 2010 Dec 1; 1(4):268-275.
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  60. Wei Y, Yemisci M, Kim HH, Yung LM, Shin HK, Hwang SK, Guo S, Qin T, Alsharif N, Brinkmann V, Liao JK, Lo EH, Waeber C. Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol. 2011 Jan; 69(1):119-29.
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  61. Khuman J, Meehan WP, Zhu X, Qiu J, Hoffmann U, Zhang J, Giovannone E, Lo EH, Whalen MJ. Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. J Cereb Blood Flow Metab. 2011 Feb; 31(2):778-89.
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  62. Hayakawa K, Qiu J, Lo EH. Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke. Ann N Y Acad Sci. 2010 Oct; 1207:50-7.
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  63. Fan X, Yu Z, Liu J, Liu N, Hajjar KA, Furie KL, Lo EH, Wang X. Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy. Stroke. 2010 Oct; 41(10 Suppl):S54-8.
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  64. Lo EH. Degeneration and repair in central nervous system disease. Nat Med. 2010 Nov; 16(11):1205-9.
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  65. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9.
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  66. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Int J Stroke. 2010 Aug; 5(4):238-56.
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  67. Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron. 2010 Jul 29; 67(2):181-98.
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  68. Qiu J, Xu J, Zheng Y, Wei Y, Zhu X, Lo EH, Moskowitz MA, Sims JR. High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia. Stroke. 2010 Sep; 41(9):2077-82.
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  69. Guo S, Stins M, Ning M, Lo EH. Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells. Cerebrovasc Dis. 2010 Aug; 30(3):290-6.
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  70. Freedman OC, Dodge J, Shaw P, Oza AM, Bernadini M, Klachook S, Murphy KJ, Lo E, Rosen B, Mackay H. Diagnosis of epithelial ovarian carcinoma prior to neoadjuvant chemotherapy. Gynecol Oncol. 2010 Oct; 119(1):22-5.
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  71. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Stroke. 2010 Jun; 41(6):1084-99.
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  72. Hayakawa K, Arai K, Lo EH. Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia. 2010 Jun; 58(8):1007-15.
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  73. Yang J, You Z, Kim HH, Hwang SK, Khuman J, Guo S, Lo EH, Whalen MJ. Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice. J Neurotrauma. 2010 Jun; 27(6):1037-46.
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  74. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Cerebrovasc Dis. 2010; 30(2):127-47.
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  75. Xing C, Arai K, Park KP, Lo EH. Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res. 2010 Jul; 35(7):1092-7.
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  76. Arai K, Lo EH. Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling. J Neurosci Res. 2010 Mar; 88(4):758-63.
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  77. Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J, Zhao S, Hajjar KA, Lo EH, Wang X. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1137-46.
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  78. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67.
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  79. Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, Jin G, Lo EH, Mishima K, Fujiwara M. Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2010 Apr; 30(4):871-82.
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  80. Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41.
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  81. Arai K, Lo EH. Experimental models for analysis of oligodendrocyte pathophysiology in stroke. Exp Transl Stroke Med. 2009; 1:6.
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  82. Lee BJ, Egi Y, van Leyen K, Lo EH, Arai K. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res. 2010 Jan 11; 1307:22-7.
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  83. Arai K, Lo EH. Oligovascular signaling in white matter stroke. Biol Pharm Bull. 2009 Oct; 32(10):1639-44.
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  84. Pallast S, Arai K, Wang X, Lo EH, van Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem. 2009 Nov; 111(3):882-9.
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  85. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH. Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res. 2009 Aug 15; 87(11):2571-7.
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  86. Foerch C, Montaner J, Furie KL, Ning MM, Lo EH. Invited article: searching for oracles? Blood biomarkers in acute stroke. Neurology. 2009 Aug 4; 73(5):393-9.
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  87. Lo EH. T time in the brain. Nat Med. 2009 Aug; 15(8):844-6.
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  88. Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009 Sep; 276(17):4644-52.
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  89. Hotokezaka Y, van Leyen K, Lo EH, Beatrix B, Katayama I, Jin G, Nakamura T. alphaNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia. Cell Death Differ. 2009 Nov; 16(11):1505-14.
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  90. Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci. 2009; 10:79.
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  91. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH. Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke. 2009 Aug; 40(8):2836-42.
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  92. Ji RR, Xu ZZ, Wang X, Lo EH. Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci. 2009 Jul; 30(7):336-40.
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  93. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X. Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience. 2009 Aug 18; 162(2):396-403.
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  94. Navaratna D, Guo S, Arai K, Lo EH. Mechanisms and targets for angiogenic therapy after stroke. Cell Adh Migr. 2009 Apr-Jun; 3(2):216-23.
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  95. Arai K, Lo EH. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009 Apr 8; 29(14):4351-5.
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  96. Foerch C, Arai K, Van Cott EM, van Leyen K, Lo EH. Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. J Cereb Blood Flow Metab. 2009 May; 29(5):1015-21.
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  97. Yu Z, Fan X, Lo EH, Wang X. Neuroprotective roles and mechanisms of neuroglobin. Neurol Res. 2009 Mar; 31(2):122-7.
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  98. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009 Jun; 40(6):2244-50.
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  99. Rosell A, Arai K, Lok J, He T, Guo S, Navarro M, Montaner J, Katusic ZS, Lo EH. Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro. J Cereb Blood Flow Metab. 2009 May; 29(5):933-43.
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  100. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH. CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol. 2009 May; 217(1):165-70.
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  101. Park JW, Jang YH, Kim JM, Lee H, Park WK, Lim MB, Chu YK, Lo EH, Lee SR. Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia. J Neurosci Res. 2009 Feb; 87(2):567-75.
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  102. Lee H, Park JW, Kim SP, Lo EH, Lee SR. Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia. Neurobiol Dis. 2009 May; 34(2):189-98.
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  103. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009 Jan; 87(1):164-70.
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  104. Ning M, Wang X, Lo EH. Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier. Handb Clin Neurol. 2009; 92:117-36.
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  105. Devor A, Hillman EM, Tian P, Waeber C, Teng IC, Ruvinskaya L, Shalinsky MH, Zhu H, Haslinger RH, Narayanan SN, Ulbert I, Dunn AK, Lo EH, Rosen BR, Dale AM, Kleinfeld D, Boas DA. Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci. 2008 Dec 31; 28(53):14347-57.
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  106. Lu J, Dai G, Egi Y, Huang S, Kwon SJ, Lo EH, Kim YR. Characterization of cerebrovascular responses to hyperoxia and hypercapnia using MRI in rat. Neuroimage. 2009 May 1; 45(4):1126-34.
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  107. Lo EH, Rosenberg GA. The neurovascular unit in health and disease: introduction. Stroke. 2009 Mar; 40(3 Suppl):S2-3.
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  108. Guo S, Lo EH. Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system disease. Stroke. 2009 Mar; 40(3 Suppl):S4-7.
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  109. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH. Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem. 2009 Jan; 108(2):430-6.
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  110. Guo S, Arai K, Stins MF, Chuang DM, Lo EH. Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke. 2009 Feb; 40(2):652-5.
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  111. Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH. Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke. 2008 Dec; 39(12):3372-7.
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  112. Kim YR, Tejima E, Huang S, Atochin DN, Dai G, Lo EH, Huang PL, Bogdanov A, Rosen BR. In vivo quantification of transvascular water exchange during the acute phase of permanent stroke. Magn Reson Med. 2008 Oct; 60(4):813-21.
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  113. Foerch C, Arai K, Jin G, Park KP, Pallast S, van Leyen K, Lo EH. Experimental model of warfarin-associated intracerebral hemorrhage. Stroke. 2008 Dec; 39(12):3397-404.
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  114. Lok J, Sardi SP, Guo S, Besancon E, Ha DM, Rosell A, Kim WJ, Corfas G, Lo EH. Neuregulin-1 signaling in brain endothelial cells. J Cereb Blood Flow Metab. 2009 Jan; 29(1):39-43.
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  115. Jin G, Arai K, Murata Y, Wang S, Stins MF, Lo EH, van Leyen K. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke. 2008 Sep; 39(9):2538-43.
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  116. Wang X, Rosell A, Lo EH. Targeting extracellular matrix proteolysis for hemorrhagic complications of tPA stroke therapy. CNS Neurol Disord Drug Targets. 2008 Jun; 7(3):235-42.
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  117. Guo S, Kim WJ, Lok J, Lee SR, Besancon E, Luo BH, Stins MF, Wang X, Dedhar S, Lo EH. Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7582-7.
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  118. Lo EH. A new penumbra: transitioning from injury into repair after stroke. Nat Med. 2008 May; 14(5):497-500.
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  119. Sun PZ, Murata Y, Lu J, Wang X, Lo EH, Sorensen AG. Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke. Magn Reson Med. 2008 May; 59(5):1175-82.
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  120. Ding MC, Lo EH, Stanley GB. Sustained focal cortical compression reduces electrically-induced seizure threshold. Neuroscience. 2008 Jun 23; 154(2):551-5.
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  121. Wang X, Liu J, Zhu H, Tejima E, Tsuji K, Murata Y, Atochin DN, Huang PL, Zhang C, Lo EH. Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke. 2008 Jun; 39(6):1869-74.
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  122. Besancon E, Guo S, Lok J, Tymianski M, Lo EH. Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends Pharmacol Sci. 2008 May; 29(5):268-75.
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  123. Rosell A, Cuadrado E, Ortega-Aznar A, Hernández-Guillamon M, Lo EH, Montaner J. MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke. 2008 Apr; 39(4):1121-6.
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  124. van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008 Mar; 86(4):904-9.
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  125. Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, Tan PH, Gao YJ, Roy K, Corfas G, Lo EH, Ji RR. Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med. 2008 Mar; 14(3):331-6.
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  126. Rosell A, Lo EH. Multiphasic roles for matrix metalloproteinases after stroke. Curr Opin Pharmacol. 2008 Feb; 8(1):82-9.
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  127. Kim YR, van Meer MP, Tejima E, Murata Y, Mandeville JB, Dai G, Chuang DM, Rosen BR, Lo EH. Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia. Stroke. 2008 Feb; 39(2):439-47.
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  128. Singhal AB, Lo EH. Advances in emerging nondrug therapies for acute stroke 2007. Stroke. 2008 Feb; 39(2):289-91.
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  129. Rosell A, Foerch C, Murata Y, Lo EH. Mechanisms and markers for hemorrhagic transformation after stroke. Acta Neurochir Suppl. 2008; 105:173-8.
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  130. Lo EH. Experimental models, neurovascular mechanisms and translational issues in stroke research. Br J Pharmacol. 2008 Mar; 153 Suppl 1:S396-405.
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  131. Kelly PJ, Morrow JD, Ning M, Koroshetz W, Lo EH, Terry E, Milne GL, Hubbard J, Lee H, Stevenson E, Lederer M, Furie KL. Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Stroke. 2008 Jan; 39(1):100-4.
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  132. Lok J, Wang H, Murata Y, Zhu HH, Qin T, Whalen MJ, Lo EH. Effect of neuregulin-1 on histopathological and functional outcome after controlled cortical impact in mice. J Neurotrauma. 2007 Dec; 24(12):1817-22.
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  133. Lee SR, Lok J, Rosell A, Kim HY, Murata Y, Atochin D, Huang PL, Wang X, Ayata C, Moskowitz MA, Lo EH. Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia. Neuroscience. 2007 Nov 30; 150(1):50-7.
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  134. Whalen MJ, Dalkara T, You Z, Qiu J, Bermpohl D, Mehta N, Suter B, Bhide PG, Lo EH, Ericsson M, Moskowitz MA. Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2008 Mar; 28(3):490-505.
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  135. Shin HK, Dunn AK, Jones PB, Boas DA, Lo EH, Moskowitz MA, Ayata C. Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain. 2007 Jun; 130(Pt 6):1631-42.
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  136. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K, Lo EH. Cell-cell signaling in the neurovascular unit. Neurochem Res. 2007 Dec; 32(12):2032-45.
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  137. Bermpohl D, You Z, Lo EH, Kim HH, Whalen MJ. TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1806-18.
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  138. Zhao BQ, Tejima E, Lo EH. Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke. Stroke. 2007 Feb; 38(2 Suppl):748-52.
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  139. Lee SR, Guo SZ, Scannevin RH, Magliaro BC, Rhodes KJ, Wang X, Lo EH. Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators. Neurosci Lett. 2007 Apr 24; 417(1):1-5.
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  140. Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D. Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging. Radiology. 2006 Dec; 241(3):822-30.
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  141. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke. 2006 Dec; 37(12):3014-8.
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  142. Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res. 2006 Sep 21; 1111(1):222-6.
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  143. Tejima E, Zhao BQ, Tsuji K, Rosell A, van Leyen K, Gonzalez RG, Montaner J, Wang X, Lo EH. Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage. J Cereb Blood Flow Metab. 2007 Mar; 27(3):460-8.
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  144. Wang S, Lee SR, Guo SZ, Kim WJ, Montaner J, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes. Stroke. 2006 Jul; 37(7):1910-2.
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  145. Ning M, Furie KL, Koroshetz WJ, Lee H, Barron M, Lederer M, Wang X, Zhu M, Sorensen AG, Lo EH, Kelly PJ. Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke. Neurology. 2006 May 23; 66(10):1550-5.
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  146. Kim YR, van Meer MP, Mandeville JB, Tejima E, Dai G, Topalkara K, Qui J, Dijkhuizen RM, Moskowitz MA, Lo EH, Rosen BR. fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brains. J Cereb Blood Flow Metab. 2007 Jan; 27(1):142-53.
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  147. Rosell A, Ortega-Aznar A, Alvarez-Sabín J, Fernández-Cadenas I, Ribó M, Molina CA, Lo EH, Montaner J. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke. 2006 Jun; 37(6):1399-406.
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  148. Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM. Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow Metab. 2007 Jan; 27(1):196-204.
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  149. Lee SR, Kim HY, Rogowska J, Zhao BQ, Bhide P, Parent JM, Lo EH. Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. J Neurosci. 2006 Mar 29; 26(13):3491-5.
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  150. Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang X, Lo EH. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006 Apr; 12(4):441-5.
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  151. Flaumenhaft R, Lo EH. Different strokes for rodent folks. Nat Methods. 2006 Feb; 3(2):79-80.
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  152. Lee ST, Chu K, Jung KH, Ko SY, Kim EH, Sinn DI, Lee YS, Lo EH, Kim M, Roh JK. Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia. Brain Res. 2005 Oct 5; 1058(1-2):120-8.
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  153. Singhal AB, Lo EH, Dalkara T, Moskowitz MA. Advances in stroke neuroprotection: hyperoxia and beyond. Neuroimaging Clin N Am. 2005 Aug; 15(3):697-720, xii-xiii.
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  154. Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J, Lo EH. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke. 2005 Sep; 36(9):1954-9.
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  155. Pham W, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A. Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging. Neuroimage. 2005 Oct 15; 28(1):287-92.
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  156. Kim YR, Huang IJ, Lee SR, Tejima E, Mandeville JB, van Meer MP, Dai G, Choi YW, Dijkhuizen RM, Lo EH, Rosen BR. Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in rats. J Cereb Blood Flow Metab. 2005 Jul; 25(7):820-9.
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  157. Asahi M, Huang Z, Thomas S, Yoshimura S, Sumii T, Mori T, Qiu J, Amin-Hanjani S, Huang PL, Liao JK, Lo EH, Moskowitz MA. Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab. 2005 Jun; 25(6):722-9.
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  158. Kim HY, Singhal AB, Lo EH. Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia. Ann Neurol. 2005 Apr; 57(4):571-5.
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  159. Singhal AB, Benner T, Roccatagliata L, Koroshetz WJ, Schaefer PW, Lo EH, Buonanno FS, Gonzalez RG, Sorensen AG. A pilot study of normobaric oxygen therapy in acute ischemic stroke. Stroke. 2005 Apr; 36(4):797-802.
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  160. van Leyen K, Siddiq A, Ratan RR, Lo EH. Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity. J Neurochem. 2005 Feb; 92(4):824-30.
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  161. Lo EH, Moskowitz MA, Jacobs TP. Exciting, radical, suicidal: how brain cells die after stroke. Stroke. 2005 Feb; 36(2):189-92.
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  162. Lee SR, Wang X, Tsuji K, Lo EH. Extracellular proteolytic pathophysiology in the neurovascular unit after stroke. Neurol Res. 2004 Dec; 26(8):854-61.
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  163. Lo EH. Combination stroke therapy: easy as APC? Nat Med. 2004 Dec; 10(12):1295-6.
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  164. Wang X, Tsuji K, Lee SR, Ning M, Furie KL, Buchan AM, Lo EH. Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke. 2004 Nov; 35(11 Suppl 1):2726-30.
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  165. Kaur J, Zhao Z, Klein GM, Lo EH, Buchan AM. The neurotoxicity of tissue plasminogen activator? J Cereb Blood Flow Metab. 2004 Sep; 24(9):945-63.
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  166. Lee SR, Lo EH. Induction of caspase-mediated cell death by matrix metalloproteinases in cerebral endothelial cells after hypoxia-reoxygenation. J Cereb Blood Flow Metab. 2004 Jul; 24(7):720-7.
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  167. Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H, Wang X, Rosenberg GA, Lo EH, Moskowitz MA. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest. 2004 May; 113(10):1447-55.
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  168. Arai K, Lee SR, van Leyen K, Kurose H, Lo EH. Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells. J Neurochem. 2004 Apr; 89(1):232-9.
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  169. Tian X, Gotoh T, Tsuji K, Lo EH, Huang S, Feig LA. Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. EMBO J. 2004 Apr 7; 23(7):1567-75.
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  170. Lo EH, Broderick JP, Moskowitz MA. tPA and proteolysis in the neurovascular unit. Stroke. 2004 Feb; 35(2):354-6.
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  171. Lee SR, Tsuji K, Lee SR, Lo EH. Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. J Neurosci. 2004 Jan 21; 24(3):671-8.
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  172. Wang X, Lo EH. Triggers and mediators of hemorrhagic transformation in cerebral ischemia. Mol Neurobiol. 2003 Dec; 28(3):229-44.
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  173. Lee SR, Lo EH. Interactions between p38 mitogen-activated protein kinase and caspase-3 in cerebral endothelial cell death after hypoxia-reoxygenation. Stroke. 2003 Nov; 34(11):2704-9.
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  174. Wang X, Lee SR, Arai K, Lee SR, Tsuji K, Rebeck GW, Lo EH. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003 Oct; 9(10):1313-7.
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  175. Arai K, Lee SR, Lo EH. Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia. 2003 Sep; 43(3):254-64.
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  176. Asahi M, Rammohan R, Sumii T, Wang X, Pauw RJ, Weissig V, Torchilin VP, Lo EH. Antiactin-targeted immunoliposomes ameliorate tissue plasminogen activator-induced hemorrhage after focal embolic stroke. J Cereb Blood Flow Metab. 2003 Aug; 23(8):895-9.
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  177. Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 2003 May; 4(5):399-415.
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  178. Moskowitz MA, Lo EH. Neurogenesis and apoptotic cell death. Stroke. 2003 Feb; 34(2):324-6.
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  179. Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, Rosen BR, Lo EH. Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci. 2003 Jan 15; 23(2):510-7.
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  180. Petty MA, Lo EH. Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation. Prog Neurobiol. 2002 Dec; 68(5):311-23.
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  181. Aoki T, Sumii T, Mori T, Wang X, Lo EH. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Stroke. 2002 Nov; 33(11):2711-7.
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  182. Mori T, Wang X, Aoki T, Lo EH. Downregulation of matrix metalloproteinase-9 and attenuation of edema via inhibition of ERK mitogen activated protein kinase in traumatic brain injury. J Neurotrauma. 2002 Nov; 19(11):1411-9.
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  183. Ge Y, Wang X, Chen Z, Landman N, Lo EH, Kang JX. Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis. J Neurochem. 2002 Sep; 82(6):1360-6.
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  184. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke. 2002 Aug; 33(8):2100-4.
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  185. Singhal AB, Wang X, Sumii T, Mori T, Lo EH. Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab. 2002 Jul; 22(7):861-8.
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  186. Lo EH, Wang X, Cuzner ML. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J Neurosci Res. 2002 Jul 1; 69(1):1-9.
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  187. Wang X, Mori T, Sumii T, Lo EH. Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke. 2002 Jul; 33(7):1882-8.
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  188. Wang X, Mori T, Jung JC, Fini ME, Lo EH. Secretion of matrix metalloproteinase-2 and -9 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase. J Neurotrauma. 2002 May; 19(5):615-25.
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  189. Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab. 2002 Apr; 22(4):444-52.
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  190. Singhal AB, Dijkhuizen RM, Rosen BR, Lo EH. Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology. 2002 Mar 26; 58(6):945-52.
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  191. Sumii T, Lo EH. Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke. 2002 Mar; 33(3):831-6.
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  192. Mori T, Wang X, Kline AE, Siao CJ, Dixon CE, Tsirka SE, Lo EH. Reduced cortical injury and edema in tissue plasminogen activator knockout mice after brain trauma. Neuroreport. 2001 Dec 21; 12(18):4117-20.
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  193. Chu AC, Tsang SY, Lo EH, Fung KP. Low density lipoprotein as a targeted carrier for doxorubicin in nude mice bearing human hepatoma HepG2 cells. Life Sci. 2001 Dec 21; 70(5):591-601.
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  194. Lo EH, Singhal AB, Torchilin VP, Abbott NJ. Drug delivery to damaged brain. Brain Res Brain Res Rev. 2001 Dec; 38(1-2):140-8.
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  195. Wang X, Shimizu-Sasamata M, Moskowitz MA, Newcomb R, Lo EH. Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice. Neurosci Lett. 2001 Nov 9; 313(3):121-4.
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  196. Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001 Oct 1; 21(19):7724-32.
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  197. Asahi M, Sumii T, Fini ME, Itohara S, Lo EH. Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia. Neuroreport. 2001 Sep 17; 12(13):3003-7.
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  198. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab. 2001 Aug; 21(8):964-71.
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  199. Tejima E, Katayama Y, Suzuki Y, Kano T, Lo EH. Hemorrhagic transformation after fibrinolysis with tissue plasminogen activator: evaluation of role of hypertension with rat thromboembolic stroke model. Stroke. 2001 Jun; 32(6):1336-40.
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  200. Sumii T, Singhal AB, Asahi M, Shimizu-Sasamata M, Suzuki M, Miyata K, Lo EH. Protective effects of pamiteplase, a modified t-PA, in a rat model of embolic stroke. Neuroreport. 2001 Mar 5; 12(3):615-8.
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  201. Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab. 2000 Dec; 20(12):1681-9.
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  202. Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, Dixon CE, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci. 2000 Sep 15; 20(18):7037-42.
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  203. Aymard C, Katz R, Lafitte C, Lo E, Pénicaud A, Pradat-Diehl P, Raoul S. Presynaptic inhibition and homosynaptic depression: a comparison between lower and upper limbs in normal human subjects and patients with hemiplegia. Brain. 2000 Aug; 123 ( Pt 8):1688-702.
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  204. Sasamata M, Moskowitz MA, Lo EH. [New method for evaluating the effects of neuroprotective therapy in the hemodynamic penumbra]. Nihon Yakurigaku Zasshi. 2000 Mar; 115(3):161-9.
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  205. Asahi M, Asahi K, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2000 Mar; 20(3):452-7.
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  206. Matsushita K, Meng W, Wang X, Asahi M, Asahi K, Moskowitz MA, Lo EH. Evidence for apoptosis after intercerebral hemorrhage in rat striatum. J Cereb Blood Flow Metab. 2000 Feb; 20(2):396-404.
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  207. Kano T, Katayama Y, Tejima E, Lo EH. Hemorrhagic transformation after fibrinolytic therapy with tissue plasminogen activator in a rat thromboembolic model of stroke. Brain Res. 2000 Jan 31; 854(1-2):245-8.
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  208. Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL, Moskowitz MA. Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience. 2000; 95(3):639-45.
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  209. Meng W, Wang X, Asahi M, Kano T, Asahi K, Ackerman RH, Lo EH. Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1999 Dec; 19(12):1316-21.
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  210. Wang X, Asahi M, Lo EH. Tissue type plasminogen activator amplifies hemoglobin-induced neurotoxicity in rat neuronal cultures. Neurosci Lett. 1999 Oct 22; 274(2):79-82.
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  211. Strausbaugh HJ, Green PG, Lo E, Tangemann K, Reichling DB, Rosen SD, Levine JD. Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils. Nat Med. 1999 Sep; 5(9):1057-61.
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  212. Abbott NJ, Chugani DC, Zaharchuk G, Rosen BR, Lo EH. Delivery of imaging agents into brain. Adv Drug Deliv Rev. 1999 Apr 5; 37(1-3):253-77.
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  213. Wan H, Hu D, Lo E, Holmgren CJ, He D, Liu Y. [Atraumatic restorative treatment fillings and fissure sealants in permanent teeth--a 2-year study]. Hua Xi Kou Qiang Yi Xue Za Zhi. 1999 Feb; 17(1):42-5.
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  214. Newcomb R, Pierce AR, Kano T, Meng W, Bosque-Hamilton P, Taylor L, Curthoys N, Lo EH. Characterization of mitochondrial glutaminase and amino acids at prolonged times after experimental focal cerebral ischemia. Brain Res. 1998 Nov 30; 813(1):103-11.
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  215. Shimizu-Sasamata M, Bosque-Hamilton P, Huang PL, Moskowitz MA, Lo EH. Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene. J Neurosci. 1998 Nov 15; 18(22):9564-71.
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  216. Kano T, Shimizu-Sasamata M, Huang PL, Moskowitz MA, Lo EH. Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo. Neuroscience. 1998 Oct; 86(3):695-9.
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  217. Shimizu-Sasamata M, Kano T, Rogowska J, Wolf GL, Moskowitz MA, Lo EH. YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats. Stroke. 1998 Oct; 29(10):2141-8.
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  218. Lo EH, Bosque-Hamilton P, Meng W. Inhibition of poly(ADP-ribose) polymerase: reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation. Stroke. 1998 Apr; 29(4):830-6.
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  219. Lo EH, Pierce AR, Matsumoto K, Kano T, Evans CJ, Newcomb R. Alterations in K+ evoked profiles of neurotransmitter and neuromodulator amino acids after focal ischemia-reperfusion. Neuroscience. 1998 Mar; 83(2):449-58.
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  220. Huang PL, Lo EH. Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals. Prog Brain Res. 1998; 118:13-25.
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  221. Pierce AR, Lo EH, Mandeville JB, Gonzalez RG, Rosen BR, Wolf GL. MRI measurements of water diffusion and cerebral perfusion: their relationship in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab. 1997 Feb; 17(2):183-90.
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  222. Lo EH, Pierce AR, Mandeville JB, Rosen BR. Neuroprotection with NBQX in rat focal cerebral ischemia. Effects on ADC probability distribution functions and diffusion-perfusion relationships. Stroke. 1997 Feb; 28(2):439-46; discussion 446-7.
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  223. Hamberg LM, Hunter GJ, Kierstead D, Lo EH, Gilberto González R, Wolf GL. Measurement of cerebral blood volume with subtraction three-dimensional functional CT. AJNR Am J Neuroradiol. 1996 Nov-Dec; 17(10):1861-9.
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  224. Lo EH, Hara H, Rogowska J, Trocha M, Pierce AR, Huang PL, Fishman MC, Wolf GL, Moskowitz MA. Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression. Stroke. 1996 Aug; 27(8):1381-5.
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  225. Yelnik A, Bonan I, Debray M, Lo E, Gelbert F, Bussel B. Changes in the execution of a complex manual task after ipsilateral ischemic cerebral hemispheric stroke. Arch Phys Med Rehabil. 1996 Aug; 77(8):806-10.
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  226. Lo EH, Rogowska J, Batchelder KF, Wolf GL. Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging. Neurol Res. 1996 Apr; 18(2):150-6.
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  227. Matsumoto K, Lo EH, Pierce AR, Halpern EF, Newcomb R. Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia. J Cereb Blood Flow Metab. 1996 Jan; 16(1):114-24.
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  228. Lo EH, Rogowska J, Bogorodzki P, Trocha M, Matsumoto K, Saffran B, Wolf GL. Temporal correlation analysis of penumbral dynamics in focal cerebral ischemia. J Cereb Blood Flow Metab. 1996 Jan; 16(1):60-8.
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  229. Pan Y, Lo EH, Matsumoto K, Hamberg L, Jiang H. Quantitative and dynamic MRI of neuroprotection in experimental stroke. J Neurol Sci. 1995 Aug; 131(2):128-34.
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  230. Matsumoto K, Lo EH, Pierce AR, Wei H, Garrido L, Kowall NW. Role of vasogenic edema and tissue cavitation in ischemic evolution on diffusion-weighted imaging: comparison with multiparameter MR and immunohistochemistry. AJNR Am J Neuroradiol. 1995 May; 16(5):1107-15.
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  231. Lo EH, Matsumoto K, Pierce AR, Garrido L, Luttinger D. Pharmacologic reversal of acute changes in diffusion-weighted magnetic resonance imaging in focal cerebral ischemia. J Cereb Blood Flow Metab. 1994 Jul; 14(4):597-603.
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  232. Safran C, Gladstone S, Lo E, Boro JE, Slack WV. Trends in computer applications in medical care. MD Comput. 1994 May-Jun; 11(3):155-9.
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  233. Lo EH, Pan Y, Matsumoto K, Kowall NW. Blood-brain barrier disruption in experimental focal ischemia: comparison between in vivo MRI and immunocytochemistry. Magn Reson Imaging. 1994; 12(3):403-11.
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  234. Lo EH. A theoretical analysis of hemodynamic and biomechanical alterations in intracranial AVMs after radiosurgery. Int J Radiat Oncol Biol Phys. 1993 Sep 30; 27(2):353-61.
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  235. Lo EH, Steinberg GK, Panahian N, Maidment NT, Newcomb R. Profiles of extracellular amino acid changes in focal cerebral ischaemia: effects of mild hypothermia. Neurol Res. 1993 Aug; 15(4):281-7.
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  236. Lo EH. A haemodynamic analysis of intracranial arteriovenous malformations. Neurol Res. 1993 Feb; 15(1):51-5.
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  237. Lo EH, Steinberg GK. Effects of hypothermia on evoked potentials, magnetic resonance imaging, and blood flow in focal ischemia in rabbits. Stroke. 1992 Jun; 23(6):889-93.
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  238. Lo EH, Frankel KA, Steinberg GK, DeLaPaz RL, Fabrikant JI. High-dose single-fraction brain irradiation: MRI, cerebral blood flow, electrophysiological, and histological studies. Int J Radiat Oncol Biol Phys. 1992; 22(1):47-55.
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  239. Steinberg GK, Lo EH, Kunis DM, Grant GA, Poljak A, DeLaPaz R. Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia. Neurosci Lett. 1991 Dec 9; 133(2):225-8.
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  240. Lo EH, Sun GH, Steinberg GK. Effects of NMDA and calcium channel antagonists on regional cerebral blood flow. Neurosci Lett. 1991 Sep 30; 131(1):17-20.
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  241. Lo EH, Steinberg GK. Effects of dextromethorphan on regional cerebral blood flow in focal cerebral ischemia. J Cereb Blood Flow Metab. 1991 Sep; 11(5):803-9.
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  242. Lo EH, DeLaPaz RL, Frankel KA, Poljak A, Phillips MH, Brennan KM, Woodruf KH, Valk PE, Steinberg GK, Fabrikant JI. MRI and PET of delayed heavy-ion radiation injury in the rabbit brain. Int J Radiat Oncol Biol Phys. 1991 Apr; 20(4):689-96.
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  243. Lo EH, Fabrikant JI. Delayed biologic reactions to stereotactic charged-particle radiosurgery in the human brain. Stereotact Funct Neurosurg. 1991; 56(4):197-212.
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  244. Lo EH, Frankel KA, Delapaz RL, Poljak A, Woodruff KH, Brennan KM, Phillips MH, Valk PE, Steinberg GK, Fabrikant JI. Cerebrovascular and metabolic perturbations in delayed heavy charged particle radiation injury. Brain Res. 1989 Dec 11; 504(1):168-72.
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