Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Jonathan Noah Thon, PH.D.

TitleInstructor in Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Hematology
75 Francis St
Boston MA 02115
Phone617/732-5840
Fax617/355-9016

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, Dimauro S, Paw BH. Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet. 2013 Nov 7; 93(5):906-14.
    View in: PubMed
  2. Thon JN, Kitterman AC, Italiano JE. Animating platelet production adds physiological context. Trends Mol Med. 2013 Oct; 19(10):583-5.
    View in: PubMed
  3. Gobbi G, Mirandola P, Carubbi C, Masselli E, Sykes SM, Ferraro F, Nouvenne A, Thon JN, Italiano JE, Vitale M. Proplatelet generation in the mouse requires PKC{varepsilon}-dependent RhoA inhibition. Blood. 2013 Aug 15; 122(7):1305-11.
    View in: PubMed
  4. Macaulay IC, Thon JN, Tijssen MR, Steele BM, Macdonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE, Maguire PB. Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood. 2013 Jan 3; 121(1):188-96.
    View in: PubMed
  5. N├╝rnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K, Thon JN, Lloyd-Jones H, Sambrook JG, Tijssen MR, Italiano JE, Deloukas P, Gottgens B, Soranzo N, Ouwehand WH. A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood. 2012 Dec 6; 120(24):4859-68.
    View in: PubMed
  6. Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE. T granules in human platelets function in TLR9 organization and signaling. J Cell Biol. 2012 Aug 20; 198(4):561-74.
    View in: PubMed
  7. Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE, Krause DS. MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation. Blood. 2012 Sep 13; 120(11):2317-29.
    View in: PubMed
  8. Thon JN, Italiano JE. Does size matter in platelet production? Blood. 2012 Aug 23; 120(8):1552-61.
    View in: PubMed
  9. Thon JN, Devine MT, Jurak Begonja A, Tibbitts J, Italiano JE. High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production. Blood. 2012 Sep 6; 120(10):1975-84.
    View in: PubMed
  10. Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE. Microtubule and cortical forces determine platelet size during vascular platelet production. Nat Commun. 2012; 3:852.
    View in: PubMed
  11. Thon JN, Italiano JE. Visualization and manipulation of the platelet and megakaryocyte cytoskeleton. Methods Mol Biol. 2012; 788:109-25.
    View in: PubMed
  12. Thon JN, Italiano JE. Platelets: production, morphology and ultrastructure. Handb Exp Pharmacol. 2012; (210):3-22.
    View in: PubMed
  13. Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011 Aug 11; 118(6):1641-52.
    View in: PubMed
  14. Lu SJ, Li F, Yin H, Feng Q, Kimbrel EA, Hahm E, Thon JN, Wang W, Italiano JE, Cho J, Lanza R. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res. 2011 Mar; 21(3):530-45.
    View in: PubMed
  15. Thon JN, Montalvo A, Patel-Hett S, Devine MT, Richardson JL, Ehrlicher A, Larson MK, Hoffmeister K, Hartwig JH, Italiano JE. Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol. 2010 Nov 15; 191(4):861-74.
    View in: PubMed
  16. Thon JN, Italiano JE. Platelet formation. Semin Hematol. 2010 Jul; 47(3):220-6.
    View in: PubMed
  17. Chase TH, Lyons BL, Bronson RT, Foreman O, Donahue LR, Burzenski LM, Gott B, Lane P, Harris B, Ceglarek U, Thiery J, Wittenburg H, Thon JN, Italiano JE, Johnson KR, Shultz LD. The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood. 2010 Feb 11; 115(6):1267-76.
    View in: PubMed
  18. Schubert P, Thon JN, Walsh GM, Chen CH, Moore ED, Devine DV, Kast J. A signaling pathway contributing to platelet storage lesion development: targeting PI3-kinase-dependent Rap1 activation slows storage-induced platelet deterioration. Transfusion. 2009 Sep; 49(9):1944-55.
    View in: PubMed
  19. Thon JN, Schubert P, Devine DV. Platelet storage lesion: a new understanding from a proteomic perspective. Transfus Med Rev. 2008 Oct; 22(4):268-79.
    View in: PubMed
  20. Thon JN, Schubert P, Duguay M, Serrano K, Lin S, Kast J, Devine DV. Comprehensive proteomic analysis of protein changes during platelet storage requires complementary proteomic approaches. Transfusion. 2008 Mar; 48(3):425-35.
    View in: PubMed
  21. Thon JN, Devine DV. Translation of glycoprotein IIIa in stored blood platelets. Transfusion. 2007 Dec; 47(12):2260-70.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Thon's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_