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Keywords
Last Name
Institution

Stuart Holland Orkin, M.D.

TitleDavid G. Nathan Professor of Pediatrics
InstitutionDana-Farber Cancer Institute
DepartmentPediatrics
AddressDana Farber Cancer Institute
Dept. of Pediatric Oncology, 16th Floor
44 Binney St
Boston MA 02115
Phone617/355-7910
Fax617/730-0222

 Mentoring 
 completed student projects
A Genetically Engineered Mouse Model of Osteosarcoma that Closely Mimics the Human Disease
Summer, 06/12/07 - 08/31/07

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Orkin Laboratory - Mouse strains (3)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pinello L, Xu J, Orkin SH, Yuan GC. Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):E344-53.
    View in: PubMed
  2. Elagib KE, Rubinstein JD, Delehanty LL, Ngoh VS, Greer PA, Li S, Lee JK, Li Z, Orkin SH, Mihaylov IS, Goldfarb AN. Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and Is Disrupted by Leukemogenic GATA1 Mutation. Dev Cell. 2013 Dec 23; 27(6):607-20.
    View in: PubMed
  3. Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, Angeles Ade L, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, Daley G, Hochedlinger K, Kim J, Orkin SH. Distinct and combinatorial functions of jmjd2b/kdm4b and jmjd2c/kdm4c in mouse embryonic stem cell identity. Mol Cell. 2014 Jan 9; 53(1):32-48.
    View in: PubMed
  4. Xie H, Xu J, Hsu JH, Nguyen M, Fujiwara Y, Peng C, Orkin SH. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell. 2014 Jan 2; 14(1):68-80.
    View in: PubMed
  5. Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science. 2013 Oct 11; 342(6155):253-7.
    View in: PubMed
  6. Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 2013 Oct 3; 13(4):492-505.
    View in: PubMed
  7. Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013 Oct; 9(10):643-50.
    View in: PubMed
  8. Luc S, Orkin SH. Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11670-1.
    View in: PubMed
  9. Kerenyi MA, Shao Z, Hsu YJ, Guo G, Luc S, O'Brien K, Fujiwara Y, Peng C, Nguyen M, Orkin SH. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2013; 2:e00633.
    View in: PubMed
  10. Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6518-23.
    View in: PubMed
  11. Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, Li Z. ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 2013 Mar 15; 27(6):683-98.
    View in: PubMed
  12. Sankaran VG, Orkin SH. Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis. Curr Opin Genet Dev. 2013 Jun; 23(3):339-44.
    View in: PubMed
  13. Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG. Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells. Mol Cell. 2013 Mar 7; 49(5):934-46.
    View in: PubMed
  14. Sankaran VG, Orkin SH. The switch from fetal to adult hemoglobin. Cold Spring Harb Perspect Med. 2013; 3(1).
    View in: PubMed
  15. Bai X, Trowbridge JJ, Riley E, Lee JA, Dibiase A, Kaartinen VM, Orkin SH, Zon LI. TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013 Jan 15; 373(2):422-30.
    View in: PubMed
  16. Maclean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17567-72.
    View in: PubMed
  17. Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HK, Yuan GC, Orkin SH. Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis. Dev Cell. 2012 Oct 16; 23(4):796-811.
    View in: PubMed
  18. Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev. 2012 Sep 15; 26(18):2075-87.
    View in: PubMed
  19. Bauer DE, Kamran SC, Orkin SH. Reawakening fetal hemoglobin: prospects for new therapies for the ß-globin disorders. Blood. 2012 Oct 11; 120(15):2945-53.
    View in: PubMed
  20. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 3; 150(3):590-605.
    View in: PubMed
  21. Funnell AP, Norton LJ, Mak KS, Burdach J, Artuz CM, Twine NA, Wilkins MR, Power CA, Hung TT, Perdomo J, Koh P, Bell-Anderson KS, Orkin SH, Fraser ST, Perkins AC, Pearson RC, Crossley M. The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Mol Cell Biol. 2012 Aug; 32(16):3281-92.
    View in: PubMed
  22. Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest. 2012 Jul 2; 122(7):2439-43.
    View in: PubMed
  23. Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol. 2012; 13(3):R16.
    View in: PubMed
  24. Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5028-33.
    View in: PubMed
  25. Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, Cottrill KA, Shaik RS, Waxman AB, Zhang YY, Maron BA, Hartner JC, Fujiwara Y, Orkin SH, Haley KJ, Barabási AL, Loscalzo J, Chan SY. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 2012 Mar 27; 125(12):1520-32.
    View in: PubMed
  26. Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, MacKenna DA, Orkin SH, Duffield JS. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med. 2012 Feb 15; 4(121):121ra18.
    View in: PubMed
  27. Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012 Feb 15; 26(4):344-9.
    View in: PubMed
  28. Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ. A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Sci Transl Med. 2012 Mar 7; 4(124):124ra29.
    View in: PubMed
  29. Chan KS, Xu J, Wardan H, McColl B, Orkin S, Vadolas J. Generation of a genomic reporter assay system for analysis of ?- and ß-globin gene regulation. FASEB J. 2012 Apr; 26(4):1736-44.
    View in: PubMed
  30. He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 1; 26(1):37-42.
    View in: PubMed
  31. Trowbridge JJ, Orkin SH. Dnmt3a silences hematopoietic stem cell self-renewal. Nat Genet. 2012 Jan; 44(1):13-4.
    View in: PubMed
  32. He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 3; 110(3):406-15.
    View in: PubMed
  33. Kim J, Orkin SH. Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Med. 2011; 3(11):75.
    View in: PubMed
  34. Fidalgo M, Shekar PC, Ang YS, Fujiwara Y, Orkin SH, Wang J. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells. 2011 Nov; 29(11):1705-16.
    View in: PubMed
  35. Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science. 2011 Nov 18; 334(6058):993-6.
    View in: PubMed
  36. Basu-Roy U, Seo E, Ramanathapuram L, Rapp TB, Perry JA, Orkin SH, Mansukhani A, Basilico C. Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. Oncogene. 2012 May 3; 31(18):2270-82.
    View in: PubMed
  37. Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. A functional element necessary for fetal hemoglobin silencing. N Engl J Med. 2011 Sep 1; 365(9):807-14.
    View in: PubMed
  38. Lu TX, Hartner J, Lim EJ, Fabry V, Mingler MK, Cole ET, Orkin SH, Aronow BJ, Rothenberg ME. MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol. 2011 Sep 15; 187(6):3362-73.
    View in: PubMed
  39. Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG, Yan Q. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13379-86.
    View in: PubMed
  40. Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell. 2011 Jun 10; 145(6):835-50.
    View in: PubMed
  41. Orkin SH. Genome Medicine: stem cells, genomics and translational research. Genome Med. 2011; 3(6):34.
    View in: PubMed
  42. Xu J, Orkin SH. The erythroid/myeloid lineage fate paradigm takes a new player. EMBO J. 2011 Mar 16; 30(6):983-5.
    View in: PubMed
  43. Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Context-dependent function of "GATA switch" sites in vivo. Blood. 2011 May 5; 117(18):4769-72.
    View in: PubMed
  44. Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011 Feb 4; 8(2):200-13.
    View in: PubMed
  45. Bauer DE, Orkin SH. Update on fetal hemoglobin gene regulation in hemoglobinopathies. Curr Opin Pediatr. 2011 Feb; 23(1):1-8.
    View in: PubMed
  46. Sankaran VG, Menne TF, Šcepanovic D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1519-24.
    View in: PubMed
  47. Bjork BC, Fujiwara Y, Davis SW, Qiu H, Saunders TL, Sandy P, Orkin S, Camper SA, Beier DR. A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development. PLoS One. 2010; 5(12):e14375.
    View in: PubMed
  48. Wilber A, Hargrove PW, Kim YS, Riberdy JM, Sankaran VG, Papanikolaou E, Georgomanoli M, Anagnou NP, Orkin SH, Nienhuis AW, Persons DA. Therapeutic levels of fetal hemoglobin in erythroid progeny of ß-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood. 2011 Mar 10; 117(10):2817-26.
    View in: PubMed
  49. Kerenyi MA, Orkin SH. Networking erythropoiesis. J Exp Med. 2010 Nov 22; 207(12):2537-41.
    View in: PubMed
  50. Galarneau G, Palmer CD, Sankaran VG, Orkin SH, Hirschhorn JN, Lettre G. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet. 2010 Dec; 42(12):1049-51.
    View in: PubMed
  51. Sankaran VG, Lettre G, Orkin SH, Hirschhorn JN. Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Ann N Y Acad Sci. 2010 Dec; 1214:47-56.
    View in: PubMed
  52. Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW. Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell. 2010 Oct 19; 18(4):316-28.
    View in: PubMed
  53. Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 2010 Oct 15; 143(2):313-24.
    View in: PubMed
  54. Williams DA, Porter ES, Lux SE, Grier HE, Mack JW, Orkin SH. Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. Am J Hematol. 2010 Oct; 85(10):793-4.
    View in: PubMed
  55. Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ. Epigenetic memory in induced pluripotent stem cells. Nature. 2010 Sep 16; 467(7313):285-90.
    View in: PubMed
  56. Rao S, Zhen S, Roumiantsev S, McDonald LT, Yuan GC, Orkin SH. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Mol Cell Biol. 2010 Nov; 30(22):5364-80.
    View in: PubMed
  57. Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. A single cis element maintains repression of the key developmental regulator Gata2. PLoS Genet. 2010 Sep; 6(9).
    View in: PubMed
  58. Sankaran VG, Xu J, Orkin SH. Transcriptional silencing of fetal hemoglobin by BCL11A. Ann N Y Acad Sci. 2010 Aug; 1202:64-8.
    View in: PubMed
  59. Klusmann JH, Godinho FJ, Heitmann K, Maroz A, Koch ML, Reinhardt D, Orkin SH, Li Z. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev. 2010 Aug 1; 24(15):1659-72.
    View in: PubMed
  60. Orkin SH, Higgs DR. Medicine. Sickle cell disease at 100 years. Science. 2010 Jul 16; 329(5989):291-2.
    View in: PubMed
  61. Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 9; 142(1):133-43.
    View in: PubMed
  62. Snow JW, Kim J, Currie CR, Xu J, Orkin SH. Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). J Biol Chem. 2010 Sep 3; 285(36):28064-75.
    View in: PubMed
  63. Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev. 2010 Apr 15; 24(8):783-98.
    View in: PubMed
  64. Sankaran VG, Xu J, Orkin SH. Advances in the understanding of haemoglobin switching. Br J Haematol. 2010 Apr; 149(2):181-94.
    View in: PubMed
  65. Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev. 2010 Mar 1; 24(5):478-90.
    View in: PubMed
  66. Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 2010 Apr 8; 115(14):2928-37.
    View in: PubMed
  67. Kim J, Orkin SH. Systematic tracking of cell fate changes. Nat Biotechnol. 2010 Feb; 28(2):146-7.
    View in: PubMed
  68. Nathan DG, Orkin SH. Musings on genome medicine: Hepatitis C. Genome Med. 2010; 2(1):4.
    View in: PubMed
  69. Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 2009 Dec 24; 139(7):1303-14.
    View in: PubMed
  70. Nathan DG, Orkin SH. Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Genome Med. 2009; 1(12):114.
    View in: PubMed
  71. Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB. Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell. 2009 Nov 25; 36(4):682-95.
    View in: PubMed
  72. Nathan DG, Orkin SH. Musings on genome medicine: Crohn's disease. Genome Med. 2009; 1(11):103.
    View in: PubMed
  73. Nathan DG, Orkin SH. Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Genome Med. 2009; 1(10):94.
    View in: PubMed
  74. Trowbridge JJ, Snow JW, Kim J, Orkin SH. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell. 2009 Oct 2; 5(4):442-9.
    View in: PubMed
  75. Nathan DG, Orkin SH. Musings on genome medicine: the Obama effect redux. Genome Med. 2009; 1(9):86.
    View in: PubMed
  76. Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009 Aug 27; 460(7259):1093-7.
    View in: PubMed
  77. Snow JW, Orkin SH. Translational isoforms of FOG1 regulate GATA1-interacting complexes. J Biol Chem. 2009 Oct 23; 284(43):29310-9.
    View in: PubMed
  78. Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol. 2009 Sep; 29(18):5168-80.
    View in: PubMed
  79. Schindler JW, Van Buren D, Foudi A, Krejci O, Qin J, Orkin SH, Hock H. TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 2009 Jul 2; 5(1):43-53.
    View in: PubMed
  80. Nathan DG, Orkin SH. Musings on genome medicine: cholesterol and coronary artery disease. Genome Med. 2009; 1(6):60.
    View in: PubMed
  81. Nathan DG, Orkin SH. Musings on genome medicine: cancer genetics and the promise of effective treatment. Genome Med. 2009; 1(5):49.
    View in: PubMed
  82. Nathan DG, Orkin SH. Musings on genome medicine: gene therapy. Genome Med. 2009; 1(4):38.
    View in: PubMed
  83. Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev. 2009 Apr 1; 23(7):837-48.
    View in: PubMed
  84. Kim J, Cantor AB, Orkin SH, Wang J. Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc. 2009; 4(4):506-17.
    View in: PubMed
  85. Nathan DG, Orkin SH. Musings on genome medicine: the Obama effect. Genome Med. 2009; 1(3):30.
    View in: PubMed
  86. Wang J, Cantor AB, Orkin SH. Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Curr Protoc Stem Cell Biol. 2009 Mar; Chapter 1:Unit1B.5.
    View in: PubMed
  87. Nathan DG, Orkin SH. Musings on genome medicine: abuse of genetic tests. Genome Med. 2009; 1(2):18.
    View in: PubMed
  88. Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009 Apr 9; 113(15):3461-71.
    View in: PubMed
  89. Nathan DG, Orkin SH. Musings on genome medicine: genome wide association studies. Genome Med. 2009; 1(1):3.
    View in: PubMed
  90. Shen X, Orkin SH. Glimpses of the epigenetic landscape. Cell Stem Cell. 2009 Jan 9; 4(1):1-2.
    View in: PubMed
  91. Hartner JC, Walkley CR, Lu J, Orkin SH. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol. 2009 Jan; 10(1):109-15.
    View in: PubMed
  92. Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008 Dec 19; 322(5909):1839-42.
    View in: PubMed
  93. Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21; 32(4):491-502.
    View in: PubMed
  94. Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH, Peters AH. Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell. 2008 Nov; 15(5):668-79.
    View in: PubMed
  95. Walkley CR, Sankaran VG, Orkin SH. Rb and hematopoiesis: stem cells to anemia. Cell Div. 2008; 3:13.
    View in: PubMed
  96. Lettre G, Sankaran VG, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11869-74.
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  97. Beuling E, Bosse T, aan de Kerk DJ, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Dev Biol. 2008 Oct 1; 322(1):179-89.
    View in: PubMed
  98. Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 2008 Jun 15; 22(12):1662-76.
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  99. Wang J, Levasseur DN, Orkin SH. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6326-31.
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  100. Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M. Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol. 2008 Jun; 28(12):3967-78.
    View in: PubMed
  101. Kim J, Chu J, Shen X, Wang J, Orkin SH. An extended transcriptional network for pluripotency of embryonic stem cells. Cell. 2008 Mar 21; 132(6):1049-61.
    View in: PubMed
  102. Rhodes KE, Gekas C, Wang Y, Lux CT, Francis CS, Chan DN, Conway S, Orkin SH, Yoder MC, Mikkola HK. The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell. 2008 Mar 6; 2(3):252-63.
    View in: PubMed
  103. Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet. 2008 Apr; 40(4):411-20.
    View in: PubMed
  104. Cantor AB, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH. Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med. 2008 Mar 17; 205(3):611-24.
    View in: PubMed
  105. Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008 Feb 22; 132(4):631-44.
    View in: PubMed
  106. Orkin SH, Zon LI. SnapShot: hematopoiesis. Cell. 2008 Feb 22; 132(4):712.
    View in: PubMed
  107. Levasseur DN, Wang J, Dorschner MO, Stamatoyannopoulos JA, Orkin SH. Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes Dev. 2008 Mar 1; 22(5):575-80.
    View in: PubMed
  108. Sankaran VG, Orkin SH, Walkley CR. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev. 2008 Feb 15; 22(4):463-75.
    View in: PubMed
  109. Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1620-5.
    View in: PubMed
  110. Wang J, Orkin SH. A protein roadmap to pluripotency and faithful reprogramming. Cells Tissues Organs. 2008; 188(1-2):23-30.
    View in: PubMed
  111. Orkin SH, Wang J, Kim J, Chu J, Rao S, Theunissen TW, Shen X, Levasseur DN. The transcriptional network controlling pluripotency in ES cells. Cold Spring Harb Symp Quant Biol. 2008; 73:195-202.
    View in: PubMed
  112. Wang J, Theunissen TW, Orkin SH. Site-directed, virus-free, and inducible RNAi in embryonic stem cells. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20850-5.
    View in: PubMed
  113. Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH. ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 2007 Dec; 12(6):542-58.
    View in: PubMed
  114. Xie H, Orkin SH. Immunology: changed destiny. Nature. 2007 Sep 27; 449(7161):410-1.
    View in: PubMed
  115. Orkin SH, Pera M. Stem cells down under-ISSCR 2007. Cell Stem Cell. 2007 Sep 13; 1(3):271-6.
    View in: PubMed
  116. Saleque S, Kim J, Rooke HM, Orkin SH. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007 Aug 17; 27(4):562-72.
    View in: PubMed
  117. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 Jun 21; 447(7147):1007-11.
    View in: PubMed
  118. Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell. 2007 Jun 15; 129(6):1081-95.
    View in: PubMed
  119. Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR. Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):391-7.
    View in: PubMed
  120. Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006 Dec 15; 127(6):1137-50.
    View in: PubMed
  121. Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH. A protein interaction network for pluripotency of embryonic stem cells. Nature. 2006 Nov 16; 444(7117):364-8.
    View in: PubMed
  122. Ghinassi B, Sanchez M, Martelli F, Amabile G, Vannucchi AM, Migliaccio G, Orkin SH, Migliaccio AR. The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood. 2007 Feb 15; 109(4):1460-71.
    View in: PubMed
  123. Mikkola HK, Orkin SH. The journey of developing hematopoietic stem cells. Development. 2006 Oct; 133(19):3733-44.
    View in: PubMed
  124. Walkley CR, Orkin SH. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9057-62.
    View in: PubMed
  125. de Pooter RF, Schmitt TM, de la Pompa JL, Fujiwara Y, Orkin SH, Zúñiga-Pflücker JC. Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors. J Immunol. 2006 May 1; 176(9):5267-75.
    View in: PubMed
  126. Guyot B, Murai K, Fujiwara Y, Valverde-Garduno V, Hammett M, Wells S, Dear N, Orkin SH, Porcher C, Vyas P. Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1. J Biol Chem. 2006 May 12; 281(19):13733-42.
    View in: PubMed
  127. Bourquin JP, Subramanian A, Langebrake C, Reinhardt D, Bernard O, Ballerini P, Baruchel A, Cavé H, Dastugue N, Hasle H, Kaspers GL, Lessard M, Michaux L, Vyas P, van Wering E, Zwaan CM, Golub TR, Orkin SH. Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3339-44.
    View in: PubMed
  128. Orkin SH. Reactions to the Hwang scandal. Science. 2006 Feb 3; 311(5761):606-7.
    View in: PubMed
  129. Rooke HM, Orkin SH. Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood. 2006 May 1; 107(9):3527-30.
    View in: PubMed
  130. Hock H, Orkin SH. Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Curr Opin Hematol. 2006 Jan; 13(1):1-6.
    View in: PubMed
  131. Rao S, Orkin SH. Unraveling the transcriptional network controlling ES cell pluripotency. Genome Biol. 2006; 7(8):230.
    View in: PubMed
  132. Muroyama Y, Fujiwara Y, Orkin SH, Rowitch DH. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature. 2005 Nov 17; 438(7066):360-3.
    View in: PubMed
  133. Orkin SH. Chipping away at the embryonic stem cell network. Cell. 2005 Sep 23; 122(6):828-30.
    View in: PubMed
  134. Mikkola HK, Gekas C, Orkin SH, Dieterlen-Lievre F. Placenta as a site for hematopoietic stem cell development. Exp Hematol. 2005 Sep; 33(9):1048-54.
    View in: PubMed
  135. Kadri Z, Maouche-Chretien L, Rooke HM, Orkin SH, Romeo PH, Mayeux P, Leboulch P, Chretien S. Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol. 2005 Sep; 25(17):7412-22.
    View in: PubMed
  136. Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep. 2005 Sep; 6(9):879-84.
    View in: PubMed
  137. Hock H, Orkin SH. Stem cells: the road not taken. Nature. 2005 Jun 2; 435(7042):573-5.
    View in: PubMed
  138. Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005 Jun; 37(6):613-9.
    View in: PubMed
  139. Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh CA. Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science. 2005 Jun 17; 308(5729):1794-8.
    View in: PubMed
  140. Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, Enver T, Vyas P, Scadden DT. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood. 2005 Jul 15; 106(2):477-84.
    View in: PubMed
  141. Gekas C, Dieterlen-Lièvre F, Orkin SH, Mikkola HK. The placenta is a niche for hematopoietic stem cells. Dev Cell. 2005 Mar; 8(3):365-75.
    View in: PubMed
  142. Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH. Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood. 2005 May 15; 105(10):3871-4.
    View in: PubMed
  143. Mikkola HK, Orkin SH. Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods Mol Med. 2005; 105:3-22.
    View in: PubMed
  144. Tsuneto M, Tominaga A, Yamazaki H, Yoshino M, Orkin SH, Hayashi S. Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. Stem Cells. 2005; 23(1):134-43.
    View in: PubMed
  145. Cantor AB, Orkin SH. Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Semin Cell Dev Biol. 2005 Feb; 16(1):117-28.
    View in: PubMed
  146. Ling KW, Ottersbach K, van Hamburg JP, Oziemlak A, Tsai FY, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med. 2004 Oct 4; 200(7):871-82.
    View in: PubMed
  147. Rual JF, Ceron J, Koreth J, Hao T, Nicot AS, Hirozane-Kishikawa T, Vandenhaute J, Orkin SH, Hill DE, van den Heuvel S, Vidal M. Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res. 2004 Oct; 14(10B):2162-8.
    View in: PubMed
  148. Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 2004 Oct 21; 431(7011):1002-7.
    View in: PubMed
  149. Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C. A critical role for eosinophils in allergic airways remodeling. Science. 2004 Sep 17; 305(5691):1776-9.
    View in: PubMed
  150. Hock H, Meade E, Medeiros S, Schindler JW, Valk PJ, Fujiwara Y, Orkin SH. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 2004 Oct 1; 18(19):2336-41.
    View in: PubMed
  151. Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C. Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol. 2004 Sep; 24(17):7491-502.
    View in: PubMed
  152. Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, Orkin SH, Zon LI. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004 Aug; 2(8):E237.
    View in: PubMed
  153. Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, Bronson RT, Orkin SH, DePinho RA, Jacks T. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004 Apr; 5(4):375-87.
    View in: PubMed
  154. Garriga-Canut M, Orkin SH. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J Biol Chem. 2004 May 28; 279(22):23597-605.
    View in: PubMed
  155. Hahm K, Sum EY, Fujiwara Y, Lindeman GJ, Visvader JE, Orkin SH. Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol. 2004 Mar; 24(5):2074-82.
    View in: PubMed
  156. Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD. More than blood, a novel gene required for mammalian postimplantation development. Mol Cell Biol. 2004 Feb; 24(3):1168-73.
    View in: PubMed
  157. Roberts CW, Orkin SH. The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer. 2004 Feb; 4(2):133-42.
    View in: PubMed
  158. Pal S, Cantor AB, Johnson KD, Moran TB, Boyer ME, Orkin SH, Bresnick EH. Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):980-5.
    View in: PubMed
  159. Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14030-5.
    View in: PubMed
  160. Orkin SH. Priming the hematopoietic pump. Immunity. 2003 Nov; 19(5):633-4.
    View in: PubMed
  161. Fujiwara Y, Chang AN, Williams AM, Orkin SH. Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood. 2004 Jan 15; 103(2):583-5.
    View in: PubMed
  162. Fossett N, Hyman K, Gajewski K, Orkin SH, Schulz RA. Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11451-6.
    View in: PubMed
  163. Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH, Van Etten RA. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 2003 Jul 31; 424(6948):561-5.
    View in: PubMed
  164. Migliaccio AR, Rana RA, Sanchez M, Lorenzini R, Centurione L, Bianchi L, Vannucchi AM, Migliaccio G, Orkin SH. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J Exp Med. 2003 Feb 3; 197(3):281-96.
    View in: PubMed
  165. Ema M, Faloon P, Zhang WJ, Hirashima M, Reid T, Stanford WL, Orkin S, Choi K, Rossant J. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev. 2003 Feb 1; 17(3):380-93.
    View in: PubMed
  166. Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003 Jan 30; 421(6922):547-51.
    View in: PubMed
  167. Wallis D, Hamblen M, Zhou Y, Venken KJ, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003 Jan; 130(1):221-32.
    View in: PubMed
  168. Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity. 2003 Jan; 18(1):109-20.
    View in: PubMed
  169. Endoh M, Ogawa M, Orkin S, Nishikawa S. SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. EMBO J. 2002 Dec 16; 21(24):6700-8.
    View in: PubMed
  170. Roberts CW, Leroux MM, Fleming MD, Orkin SH. Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell. 2002 Nov; 2(5):415-25.
    View in: PubMed
  171. Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH. Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development. 2002 Oct; 129(19):4627-34.
    View in: PubMed
  172. Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood. 2002 Oct 1; 100(7):2430-40.
    View in: PubMed
  173. Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 2003 Jan 15; 101(2):508-16.
    View in: PubMed
  174. Yu C, Niakan KK, Matsushita M, Stamatoyannopoulos G, Orkin SH, Raskind WH. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood. 2002 Sep 15; 100(6):2040-5.
    View in: PubMed
  175. Ritchie KJ, Malakhov MP, Hetherington CJ, Zhou L, Little MT, Malakhova OA, Sipe JC, Orkin SH, Zhang DE. Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev. 2002 Sep 1; 16(17):2207-12.
    View in: PubMed
  176. Orkin SH, Morrison SJ. Stem-cell competition. Nature. 2002 Jul 4; 418(6893):25-7.
    View in: PubMed
  177. Chang AN, Cantor AB, Fujiwara Y, Lodish MB, Droho S, Crispino JD, Orkin SH. GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A. 2002 Jul 9; 99(14):9237-42.
    View in: PubMed
  178. Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, Orkin SH. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med. 2002 Jun 3; 195(11):1387-95.
    View in: PubMed
  179. Cantor AB, Katz SG, Orkin SH. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol Cell Biol. 2002 Jun; 22(12):4268-79.
    View in: PubMed
  180. Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002 May 13; 21(21):3368-76.
    View in: PubMed
  181. Katz SG, Cantor AB, Orkin SH. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Mol Cell Biol. 2002 May; 22(9):3121-8.
    View in: PubMed
  182. Orkin SH, Zon LI. Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol. 2002 Apr; 3(4):323-8.
    View in: PubMed
  183. Saleque S, Cameron S, Orkin SH. The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev. 2002 Feb 1; 16(3):301-6.
    View in: PubMed
  184. Mikkola HK, Orkin SH. The search for the hemangioblast. J Hematother Stem Cell Res. 2002 Feb; 11(1):9-17.
    View in: PubMed
  185. Crispino JD, Orkin SH. The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. Methods. 2002 Jan; 26(1):84-92.
    View in: PubMed
  186. Han AP, Yu C, Lu L, Fujiwara Y, Browne C, Chin G, Fleming M, Leboulch P, Orkin SH, Chen JJ. Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J. 2001 Dec 3; 20(23):6909-18.
    View in: PubMed
  187. Murga M, Fernández-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, Balomenos D, Vicario A, Carrera AC, Orkin SH, Greenberg ME, Zubiaga AM. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 2001 Dec; 15(6):959-70.
    View in: PubMed
  188. Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol. 2001 Dec; 21(24):8547-64.
    View in: PubMed
  189. Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001 Nov 22; 414(6862):457-62.
    View in: PubMed
  190. Zhou M, Ouyang W, Gong Q, Katz SG, White JM, Orkin SH, Murphy KM. Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. J Exp Med. 2001 Nov 19; 194(10):1461-71.
    View in: PubMed
  191. Jasinski M, Keller P, Fujiwara Y, Orkin SH, Bessler M. GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells). Blood. 2001 Oct 1; 98(7):2248-55.
    View in: PubMed
  192. Cantor AB, Orkin SH. Hematopoietic development: a balancing act. Curr Opin Genet Dev. 2001 Oct; 11(5):513-9.
    View in: PubMed
  193. Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul; 8(1):105-13.
    View in: PubMed
  194. Fossett N, Tevosian SG, Gajewski K, Zhang Q, Orkin SH, Schulz RA. The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7342-7.
    View in: PubMed
  195. Mead PE, Deconinck AE, Huber TL, Orkin SH, Zon LI. Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development. 2001 Jun; 128(12):2301-8.
    View in: PubMed
  196. Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 2001 Apr 1; 15(7):839-44.
    View in: PubMed
  197. Mao X, Fujiwara Y, Chapdelaine A, Yang H, Orkin SH. Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood. 2001 Jan 1; 97(1):324-6.
    View in: PubMed
  198. Roberts CW, Galusha SA, McMenamin ME, Fletcher CD, Orkin SH. Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13796-800.
    View in: PubMed
  199. Vyas P, Norris FA, Joseph R, Majerus PW, Orkin SH. Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13696-701.
    View in: PubMed
  200. Orkin SH. Stem cell alchemy. Nat Med. 2000 Nov; 6(11):1212-3.
    View in: PubMed
  201. Kappel A, Schlaeger TM, Flamme I, Orkin SH, Risau W, Breier G. Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development. Blood. 2000 Nov 1; 96(9):3078-85.
    View in: PubMed
  202. Zhang P, Zhang X, Iwama A, Yu C, Smith KA, Mueller BU, Narravula S, Torbett BE, Orkin SH, Tenen DG. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 2000 Oct 15; 96(8):2641-8.
    View in: PubMed
  203. Orkin SH. Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet. 2000 Oct; 1(1):57-64.
    View in: PubMed
  204. Querfurth E, Schuster M, Kulessa H, Crispino JD, Döderlein G, Orkin SH, Graf T, Nerlov C. Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. Genes Dev. 2000 Oct 1; 14(19):2515-25.
    View in: PubMed
  205. Yamane T, Kunisada T, Yamazaki H, Nakano T, Orkin SH, Hayashi SI. Sequential requirements for SCL/tal-1, GATA-2, macrophage colony-stimulating factor, and osteoclast differentiation factor/osteoprotegerin ligand in osteoclast development. Exp Hematol. 2000 Jul; 28(7):833-40.
    View in: PubMed
  206. Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol. 2000 Jun 29; 10(13):758-65.
    View in: PubMed
  207. Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH. FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000 Jun 23; 101(7):729-39.
    View in: PubMed
  208. Lewis BA, Kim TK, Orkin SH. A downstream element in the human beta-globin promoter: evidence of extended sequence-specific transcription factor IID contacts. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7172-7.
    View in: PubMed
  209. Shirihai OS, Gregory T, Yu C, Orkin SH, Weiss MJ. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J. 2000 Jun 1; 19(11):2492-502.
    View in: PubMed
  210. Deconinck AE, Mead PE, Tevosian SG, Crispino JD, Katz SG, Zon LI, Orkin SH. FOG acts as a repressor of red blood cell development in Xenopus. Development. 2000 May; 127(10):2031-40.
    View in: PubMed
  211. Faloon P, Arentson E, Kazarov A, Deng CX, Porcher C, Orkin S, Choi K. Basic fibroblast growth factor positively regulates hematopoietic development. Development. 2000 May; 127(9):1931-41.
    View in: PubMed
  212. Perkins AC, Peterson KR, Stamatoyannopoulos G, Witkowska HE, Orkin SH. Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. Blood. 2000 Mar 1; 95(5):1827-33.
    View in: PubMed
  213. Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet. 2000 Mar; 24(3):266-70.
    View in: PubMed
  214. Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH. An essential role in liver development for transcription factor XBP-1. Genes Dev. 2000 Jan 15; 14(2):152-7.
    View in: PubMed
  215. Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development. 1999 Oct; 126(20):4603-15.
    View in: PubMed
  216. Orkin SH, Weiss MJ. Apoptosis. Cutting red-cell production. Nature. 1999 Sep 30; 401(6752):433, 435-6.
    View in: PubMed
  217. Alberts BM, Ayala FJ, Botstein D, Frank E, Holmes EW, Lee RD, Macagno ER, Marrack P, Oparil S, Orkin SH, Rubenstein AH, Slayman CW, Sparling PF, Squire LR, von Hippel PH, Yamamoto KR. Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health. Science. 1999 Jul 30; 285(5428):666-7.
    View in: PubMed
  218. Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood. 1999 Jul 1; 94(1):87-96.
    View in: PubMed
  219. Nardelli J, Thiesson D, Fujiwara Y, Tsai FY, Orkin SH. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol. 1999 Jun 15; 210(2):305-21.
    View in: PubMed
  220. Vyas P, McDevitt MA, Cantor AB, Katz SG, Fujiwara Y, Orkin SH. Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development. 1999 Jun; 126(12):2799-811.
    View in: PubMed
  221. Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA. Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood. 1999 May 1; 93(9):2867-75.
    View in: PubMed
  222. Mao X, Fujiwara Y, Orkin SH. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5037-42.
    View in: PubMed
  223. Orkin SH, Porcher C, Fujiwara Y, Visvader J, Wang LC. Intersections between blood cell development and leukemia genes. Cancer Res. 1999 Apr 1; 59(7 Suppl):1784s-1787s; discussion 1788s.
    View in: PubMed
  224. Tevosian SG, Deconinck AE, Cantor AB, Rieff HI, Fujiwara Y, Corfas G, Orkin SH. FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc Natl Acad Sci U S A. 1999 Feb 2; 96(3):950-5.
    View in: PubMed
  225. Crispino JD, Lodish MB, MacKay JP, Orkin SH. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol Cell. 1999 Feb; 3(2):219-28.
    View in: PubMed
  226. Strauss EC, Orkin SH. Guanine-adenine ligation-mediated polymerase chain reaction in vivo footprinting. Methods Enzymol. 1999; 304:572-84.
    View in: PubMed
  227. Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998 Dec 23; 95(7):891-902.
    View in: PubMed
  228. Zhou Y, Lim KC, Onodera K, Takahashi S, Ohta J, Minegishi N, Tsai FY, Orkin SH, Yamamoto M, Engel JD. Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J. 1998 Nov 16; 17(22):6689-700.
    View in: PubMed
  229. Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 1998 Aug 1; 12(15):2392-402.
    View in: PubMed
  230. Tsang AP, Fujiwara Y, Hom DB, Orkin SH. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998 Apr 15; 12(8):1176-88.
    View in: PubMed
  231. Tsai FY, Browne CP, Orkin SH. Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Dev Biol. 1998 Apr 15; 196(2):218-27.
    View in: PubMed
  232. Guy LG, Mei Q, Perkins AC, Orkin SH, Wall L. Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression. Blood. 1998 Apr 1; 91(7):2259-63.
    View in: PubMed
  233. Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc Natl Acad Sci U S A. 1998 Mar 3; 95(5):2061-6.
    View in: PubMed
  234. Visvader JE, Fujiwara Y, Orkin SH. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev. 1998 Feb 15; 12(4):473-9.
    View in: PubMed
  235. Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development. Stem Cells. 1998; 16 Suppl 2:79-83.
    View in: PubMed
  236. Orkin SH. Embryonic stem cells and transgenic mice in the study of hematopoiesis. Int J Dev Biol. 1998; 42(7):927-34.
    View in: PubMed
  237. Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A. 1997 Dec 9; 94(25):13707-12.
    View in: PubMed
  238. Deveaux S, Cohen-Kaminsky S, Shivdasani RA, Andrews NC, Filipe A, Kuzniak I, Orkin SH, Roméo PH, Mignotte V. p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J. 1997 Sep 15; 16(18):5654-61.
    View in: PubMed
  239. Shivdasani RA, Fielder P, Keller GA, Orkin SH, de Sauvage FJ. Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood. 1997 Sep 1; 90(5):1821-7.
    View in: PubMed
  240. Qu CK, Shi ZQ, Shen R, Tsai FY, Orkin SH, Feng GS. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol. 1997 Sep; 17(9):5499-507.
    View in: PubMed
  241. McDevitt MA, Fujiwara Y, Shivdasani RA, Orkin SH. An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7976-81.
    View in: PubMed
  242. Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 1997 Jul 16; 16(14):4374-83.
    View in: PubMed
  243. Tsang AP, Visvader JE, Turner CA, Fujiwara Y, Yu C, Weiss MJ, Crossley M, Orkin SH. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 1997 Jul 11; 90(1):109-19.
    View in: PubMed
  244. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 1; 16(13):3965-73.
    View in: PubMed
  245. McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH. A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6781-5.
    View in: PubMed
  246. Tsai FY, Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood. 1997 May 15; 89(10):3636-43.
    View in: PubMed
  247. Lien LL, Lee Y, Orkin SH. Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements. Mol Cell Biol. 1997 Apr; 17(4):2279-90.
    View in: PubMed
  248. Weiss MJ, Yu C, Orkin SH. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol Cell Biol. 1997 Mar; 17(3):1642-51.
    View in: PubMed
  249. Ma GT, Roth ME, Groskopf JC, Tsai FY, Orkin SH, Grosveld F, Engel JD, Linzer DI. GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development. 1997 Feb; 124(4):907-14.
    View in: PubMed
  250. Strauss EC, Orkin SH. Guanine-adenine ligation-mediated PCR in vivo footprinting. Methods. 1997 Feb; 11(2):164-70.
    View in: PubMed
  251. Orkin SH, Zon LI. Genetics of erythropoiesis: induced mutations in mice and zebrafish. Annu Rev Genet. 1997; 31:33-60.
    View in: PubMed
  252. Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12355-8.
    View in: PubMed
  253. Perkins AC, Gaensler KM, Orkin SH. Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12267-71.
    View in: PubMed
  254. Orkin SH. Development of the hematopoietic system. Curr Opin Genet Dev. 1996 Oct; 6(5):597-602.
    View in: PubMed
  255. Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE. Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27.
    View in: PubMed
  256. Kieran MW, Perkins AC, Orkin SH, Zon LI. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9126-31.
    View in: PubMed
  257. Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 1996 Jul 12; 86(1):47-57.
    View in: PubMed
  258. Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996 May 17; 85(4):549-61.
    View in: PubMed
  259. Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. Blood. 1996 May 15; 87(10):4025-39.
    View in: PubMed
  260. Kotkow KJ, Orkin SH. Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3514-8.
    View in: PubMed
  261. Blobel GA, Orkin SH. Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1. Mol Cell Biol. 1996 Apr; 16(4):1687-94.
    View in: PubMed
  262. Crossley M, Whitelaw E, Perkins A, Williams G, Fujiwara Y, Orkin SH. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol Cell Biol. 1996 Apr; 16(4):1695-705.
    View in: PubMed
  263. Weiss MJ, Orkin SH. In vitro differentiation of murine embryonic stem cells. New approaches to old problems. J Clin Invest. 1996 Feb 1; 97(3):591-5.
    View in: PubMed
  264. Orkin SH. Hematopoiesis: how does it happen? Curr Opin Cell Biol. 1995 Dec; 7(6):870-7.
    View in: PubMed
  265. Lewis BA, Orkin SH. A functional initiator element in the human beta-globin promoter. J Biol Chem. 1995 Nov 24; 270(47):28139-44.
    View in: PubMed
  266. Weiss MJ, Orkin SH. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9623-7.
    View in: PubMed
  267. Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8690-4.
    View in: PubMed
  268. Kotkow KJ, Orkin SH. Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer. Mol Cell Biol. 1995 Aug; 15(8):4640-7.
    View in: PubMed
  269. Orkin SH. Regulation of globin gene expression in erythroid cells. Eur J Biochem. 1995 Jul 15; 231(2):271-81.
    View in: PubMed
  270. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 1995 Jun 2; 81(5):695-704.
    View in: PubMed
  271. Blobel GA, Sieff CA, Orkin SH. Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor. Mol Cell Biol. 1995 Jun; 15(6):3147-53.
    View in: PubMed
  272. Perkins AC, Sharpe AH, Orkin SH. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25; 375(6529):318-22.
    View in: PubMed
  273. Crossley M, Merika M, Orkin SH. Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains. Mol Cell Biol. 1995 May; 15(5):2448-56.
    View in: PubMed
  274. Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. J Exp Med. 1995 May 1; 181(5):1603-13.
    View in: PubMed
  275. Merika M, Orkin SH. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol. 1995 May; 15(5):2437-47.
    View in: PubMed
  276. Chui DH, Tang W, Orkin SH. cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor. Biochem Biophys Res Commun. 1995 Apr 6; 209(1):40-6.
    View in: PubMed
  277. Zhang R, Alt FW, Davidson L, Orkin SH, Swat W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature. 1995 Mar 30; 374(6521):470-3.
    View in: PubMed
  278. Orkin SH. Transcription factors and hematopoietic development. J Biol Chem. 1995 Mar 10; 270(10):4955-8.
    View in: PubMed
  279. Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995 Feb 2; 373(6513):432-4.
    View in: PubMed
  280. Blobel GA, Simon MC, Orkin SH. Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins. Mol Cell Biol. 1995 Feb; 15(2):626-33.
    View in: PubMed
  281. Weiss MJ, Orkin SH. GATA transcription factors: key regulators of hematopoiesis. Exp Hematol. 1995 Feb; 23(2):99-107.
    View in: PubMed
  282. Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J, Orkin SH, Doerschuk CM, Dinauer MC. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet. 1995 Feb; 9(2):202-9.
    View in: PubMed
  283. Visvader JE, Crossley M, Hill J, Orkin SH, Adams JM. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Mol Cell Biol. 1995 Feb; 15(2):634-41.
    View in: PubMed
  284. Ney PA, Farina SF, Bodine DM, Andrews NC, Orkin SH, Neinhuis AW. Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2. Exp Hematol. 1995 Jan; 23(1):74-80.
    View in: PubMed
  285. Pevny L, Lin CS, D'Agati V, Simon MC, Orkin SH, Costantini F. Development of hematopoietic cells lacking transcription factor GATA-1. Development. 1995 Jan; 121(1):163-72.
    View in: PubMed
  286. Zhang R, Tsai FY, Orkin SH. Hematopoietic development of vav-/- mouse embryonic stem cells. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12755-9.
    View in: PubMed
  287. Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994 Sep 15; 371(6494):221-6.
    View in: PubMed
  288. Aufiero B, Neufeld EJ, Orkin SH. Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein. Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16):7757-61.
    View in: PubMed
  289. Crossley M, Orkin SH. Phosphorylation of the erythroid transcription factor GATA-1. J Biol Chem. 1994 Jun 17; 269(24):16589-96.
    View in: PubMed
  290. Crossley M, Tsang AP, Bieker JJ, Orkin SH. Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. J Biol Chem. 1994 Jun 3; 269(22):15440-4.
    View in: PubMed
  291. Weiss MJ, Keller G, Orkin SH. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev. 1994 May 15; 8(10):1184-97.
    View in: PubMed
  292. Andrews NC, Orkin SH. Transcriptional control of erythropoiesis. Curr Opin Hematol. 1994 Mar; 1(2):119-24.
    View in: PubMed
  293. Gessler M, König A, Arden K, Grundy P, Orkin S, Sallan S, Peters C, Ruyle S, Mandell J, Li F, et al. Infrequent mutation of the WT1 gene in 77 Wilms' Tumors. Hum Mutat. 1994; 3(3):212-22.
    View in: PubMed
  294. Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11488-92.
    View in: PubMed
  295. Zhen L, King AA, Xiao Y, Chanock SJ, Orkin SH, Dinauer MC. Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. Proc Natl Acad Sci U S A. 1993 Nov 1; 90(21):9832-6.
    View in: PubMed
  296. Bodine DM, Moritz T, Donahue RE, Luskey BD, Kessler SW, Martin DI, Orkin SH, Nienhuis AW, Williams DA. Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood. 1993 Oct 1; 82(7):1975-80.
    View in: PubMed
  297. Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW. Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Mol Cell Biol. 1993 Sep; 13(9):5604-12.
    View in: PubMed
  298. Kreider BL, Orkin SH, Ihle JN. Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6454-8.
    View in: PubMed
  299. Merika M, Orkin SH. DNA-binding specificity of GATA family transcription factors. Mol Cell Biol. 1993 Jul; 13(7):3999-4010.
    View in: PubMed
  300. Zon LI, Yamaguchi Y, Yee K, Albee EA, Kimura A, Bennett JC, Orkin SH, Ackerman SJ. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood. 1993 Jun 15; 81(12):3234-41.
    View in: PubMed
  301. Peters LL, Andrews NC, Eicher EM, Davidson MB, Orkin SH, Lux SE. Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Nature. 1993 Apr 22; 362(6422):768-70.
    View in: PubMed
  302. Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH. Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature. 1993 Apr 22; 362(6422):722-8.
    View in: PubMed
  303. Arceci RJ, King AA, Simon MC, Orkin SH, Wilson DB. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993 Apr; 13(4):2235-46.
    View in: PubMed
  304. Crossley M, Orkin SH. Regulation of the beta-globin locus. Curr Opin Genet Dev. 1993 Apr; 3(2):232-7.
    View in: PubMed
  305. Scherer SW, Neufeld EJ, Lievens PM, Orkin SH, Kim J, Tsui LC. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids. Genomics. 1993 Mar; 15(3):695-6.
    View in: PubMed
  306. Aplan PD, Nakahara K, Orkin SH, Kirsch IR. The SCL gene product: a positive regulator of erythroid differentiation. EMBO J. 1992 Nov; 11(11):4073-81.
    View in: PubMed
  307. de Boer M, Bolscher BG, Dinauer MC, Orkin SH, Smith CI, Ahlin A, Weening RS, Roos D. Splice site mutations are a common cause of X-linked chronic granulomatous disease. Blood. 1992 Sep 15; 80(6):1553-8.
    View in: PubMed
  308. Orkin SH. GATA-binding transcription factors in hematopoietic cells. Blood. 1992 Aug 1; 80(3):575-81.
    View in: PubMed
  309. Sposi NM, Zon LI, Carè A, Valtieri M, Testa U, Gabbianelli M, Mariani G, Bottero L, Mather C, Orkin SH, et al. Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6353-7.
    View in: PubMed
  310. Strauss EC, Orkin SH. In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):5809-13.
    View in: PubMed
  311. Strauss EC, Andrews NC, Higgs DR, Orkin SH. In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction. Mol Cell Biol. 1992 May; 12(5):2135-42.
    View in: PubMed
  312. Simon MC, Pevny L, Wiles MV, Keller G, Costantini F, Orkin SH. Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat Genet. 1992 May; 1(2):92-8.
    View in: PubMed
  313. Zon LI, Orkin SH. Sequence of the human GATA-1 promoter. Nucleic Acids Res. 1992 Apr 11; 20(7):1812.
    View in: PubMed
  314. Neufeld EJ, Skalnik DG, Lievens PM, Orkin SH. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat Genet. 1992 Apr; 1(1):50-5.
    View in: PubMed
  315. Dorfman DM, Wilson DB, Bruns GA, Orkin SH. Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J Biol Chem. 1992 Jan 15; 267(2):1279-85.
    View in: PubMed
  316. Dinauer MC, Orkin SH. Chronic granulomatous disease. Annu Rev Med. 1992; 43:117-24.
    View in: PubMed
  317. Dinauer MC, Pierce EA, Erickson RW, Muhlebach TJ, Messner H, Orkin SH, Seger RA, Curnutte JT. Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11231-5.
    View in: PubMed
  318. Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5; 266(34):22948-53.
    View in: PubMed
  319. Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10638-41.
    View in: PubMed
  320. Zon LI, Mather C, Burgess S, Bolce ME, Harland RM, Orkin SH. Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10642-6.
    View in: PubMed
  321. Skalnik DG, Dorfman DM, Perkins AS, Jenkins NA, Copeland NG, Orkin SH. Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies. Proc Natl Acad Sci U S A. 1991 Oct 1; 88(19):8505-9.
    View in: PubMed
  322. Skalnik DG, Strauss EC, Orkin SH. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. J Biol Chem. 1991 Sep 5; 266(25):16736-44.
    View in: PubMed
  323. Skalnik DG, Dorfman DM, Williams DA, Orkin SH. Restriction of neuroblastoma to the prostate gland in transgenic mice. Mol Cell Biol. 1991 Sep; 11(9):4518-27.
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  324. Marsden PA, Dorfman DM, Collins T, Brenner BM, Orkin SH, Ballermann BJ. Regulated expression of endothelin 1 in glomerular capillary endothelial cells. Am J Physiol. 1991 Jul; 261(1 Pt 2):F117-25.
    View in: PubMed
  325. Tsai SF, Strauss E, Orkin SH. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 1991 Jun; 5(6):919-31.
    View in: PubMed
  326. Ho IC, Vorhees P, Marin N, Oakley BK, Tsai SF, Orkin SH, Leiden JM. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. EMBO J. 1991 May; 10(5):1187-92.
    View in: PubMed
  327. Chapman VM, Stephenson DA, Mullins LJ, Keitz BT, Disteche C, Orkin SH. Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice. Genomics. 1991 Feb; 9(2):309-13.
    View in: PubMed
  328. Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Costantini F. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991 Jan 17; 349(6306):257-60.
    View in: PubMed
  329. Ezekowitz RA, Sieff CA, Dinauer MC, Nathan DG, Orkin SH, Newburger PE. Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. Blood. 1990 Dec 15; 76(12):2443-8.
    View in: PubMed
  330. Whitelaw E, Tsai SF, Hogben P, Orkin SH. Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse. Mol Cell Biol. 1990 Dec; 10(12):6596-606.
    View in: PubMed
  331. Orkin SH. Preparing for the next generation. J Clin Invest. 1990 Dec; 86(6):1773-6.
    View in: PubMed
  332. Orkin SH. Cell-specific transcription and cell differentiation in the erythroid lineage. Curr Opin Cell Biol. 1990 Dec; 2(6):1003-12.
    View in: PubMed
  333. Orkin SH. Globin gene regulation and switching: circa 1990. Cell. 1990 Nov 16; 63(4):665-72.
    View in: PubMed
  334. Young RM, Mendoza AE, Collins T, Orkin SH. Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins. Mol Cell Biol. 1990 Nov; 10(11):6051-4.
    View in: PubMed
  335. Martin DI, Orkin SH. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev. 1990 Nov; 4(11):1886-98.
    View in: PubMed
  336. Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest. 1990 Nov; 86(5):1729-37.
    View in: PubMed
  337. Yamamoto M, Ko LJ, Leonard MW, Beug H, Orkin SH, Engel JD. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev. 1990 Oct; 4(10):1650-62.
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  338. Wilson DB, Dorfman DM, Orkin SH. A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol Cell Biol. 1990 Sep; 10(9):4854-62.
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  339. Youssoufian H, Zon LI, Orkin SH, D'Andrea AD, Lodish HF. Structure and transcription of the mouse erythropoietin receptor gene. Mol Cell Biol. 1990 Jul; 10(7):3675-82.
    View in: PubMed
  340. Martin DI, Zon LI, Mutter G, Orkin SH. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature. 1990 Mar 29; 344(6265):444-7.
    View in: PubMed
  341. Mendoza AE, Young R, Orkin SH, Collins T. Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2177-81.
    View in: PubMed
  342. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GA. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature. 1990 Feb 22; 343(6260):774-8.
    View in: PubMed
  343. Luskey BD, Lim B, Apperley JF, Orkin SH, Williams DA. Gene transfer into murine hematopoietic stem cells and bone marrow stromal cells. Ann N Y Acad Sci. 1990; 612:398-406.
    View in: PubMed
  344. Skalnik DG, Dorfman DM, Perkins AS, Jenkins NA, Copeland NG, Orkin SH. Targeting of transgene expression to monocytes by cytochrome b heavy chain gene 5'-flanking sequences induces histiocytic malignancies. Trans Assoc Am Physicians. 1990; 103:129-36.
    View in: PubMed
  345. Zon LI, Tsai SF, Burgess S, Matsudaira P, Bruns GA, Orkin SH. The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):668-72.
    View in: PubMed
  346. Skalnik DG, Orkin S. A rapid method for characterizing transgenic mice. Biotechniques. 1990 Jan; 8(1):34.
    View in: PubMed
  347. Dinauer MC, Curnutte JT, Rosen H, Orkin SH. A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. J Clin Invest. 1989 Dec; 84(6):2012-6.
    View in: PubMed
  348. Quinn MT, Parkos CA, Walker L, Orkin SH, Dinauer MC, Jesaitis AJ. Association of a Ras-related protein with cytochrome b of human neutrophils. Nature. 1989 Nov 9; 342(6246):198-200.
    View in: PubMed
  349. Lim B, Apperley JF, Orkin SH, Williams DA. Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8892-6.
    View in: PubMed
  350. Wise RJ, Orkin SH, Collins T. Aberrant expression of platelet-derived growth factor A-chain cDNAs due to cryptic splicing of RNA transcripts in COS-1 cells. Nucleic Acids Res. 1989 Aug 25; 17(16):6591-601.
    View in: PubMed
  351. Zon LI, Dorfman DM, Orkin SH. The polymerase chain reaction colony miniprep. Biotechniques. 1989 Jul-Aug; 7(7):696-8.
    View in: PubMed
  352. Tsai SF, Martin DI, Zon LI, D'Andrea AD, Wong GG, Orkin SH. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 1989 Jun 8; 339(6224):446-51.
    View in: PubMed
  353. Dorfman DM, Zon LI, Orkin SH. Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR). Biotechniques. 1989 Jun; 7(6):568, 570.
    View in: PubMed
  354. Parkos CA, Dinauer MC, Jesaitis AJ, Orkin SH, Curnutte JT. Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease. Blood. 1989 May 1; 73(6):1416-20.
    View in: PubMed
  355. Martin DI, Tsai SF, Orkin SH. Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor. Nature. 1989 Mar 30; 338(6214):435-8.
    View in: PubMed
  356. Wong C, Antonarakis SE, Goff SC, Orkin SH, Forget BG, Nathan DG, Giardina PJ, Kazazian HH. Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene. Blood. 1989 Mar; 73(4):914-8.
    View in: PubMed
  357. Orkin SH. X-linked chronic granulomatous disease: more than two years later. Mol Biol Med. 1989 Feb; 6(1):1-5.
    View in: PubMed
  358. Hirschhorn R, Tzall S, Ellenbogen A, Orkin SH. Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency. J Clin Invest. 1989 Feb; 83(2):497-501.
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  359. Martin DI, Orkin SH. An erythroid-specific DNA binding factor mediates increased gamma-globin expression in hereditary persistence of fetal hemoglobin (HPFH). Prog Clin Biol Res. 1989; 316A:217-28.
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  360. Miller BA, Salameh M, Ahmed M, Olivieri N, Huisman TH, Orkin SH, Nathan DG. Saudi Arabian sickle cell anemia. A molecular approach. Ann N Y Acad Sci. 1989; 565:143-51.
    View in: PubMed
  361. Orkin SH. Molecular genetics of chronic granulomatous disease. Annu Rev Immunol. 1989; 7:277-307.
    View in: PubMed
  362. de Saint-Basile G, Bohler MC, Fischer A, Cartron J, Dufier JL, Griscelli C, Orkin SH. Xp21 DNA microdeletion in a patient with chronic granulomatous disease, retinitis pigmentosa, and McLeod phenotype. Hum Genet. 1988 Sep; 80(1):85-9.
    View in: PubMed
  363. Ezekowitz RA, Dinauer MC, Jaffe HS, Orkin SH, Newburger PE. Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma. N Engl J Med. 1988 Jul 21; 319(3):146-51.
    View in: PubMed
  364. Barker KA, Orkin SH, Newburger PE. Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60. Mol Cell Biol. 1988 Jul; 8(7):2804-10.
    View in: PubMed
  365. Newburger PE, Ezekowitz RA, Whitney C, Wright J, Orkin SH. Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5215-9.
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  366. Dinauer MC, Orkin SH. Chronic granulomatous disease. Molecular genetics. Hematol Oncol Clin North Am. 1988 Jun; 2(2):225-40.
    View in: PubMed
  367. Parkos CA, Dinauer MC, Walker LE, Allen RA, Jesaitis AJ, Orkin SH. Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b. Proc Natl Acad Sci U S A. 1988 May; 85(10):3319-23.
    View in: PubMed
  368. Bonthron DT, Morton CC, Orkin SH, Collins T. Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1492-6.
    View in: PubMed
  369. Wise RJ, Pittman DD, Handin RI, Kaufman RJ, Orkin SH. The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers. Cell. 1988 Jan 29; 52(2):229-36.
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  370. Bonthron D, Orkin SH. The human von Willebrand factor gene. Structure of the 5' region. Eur J Biochem. 1988 Jan 15; 171(1-2):51-7.
    View in: PubMed
  371. Frey D, Mächler M, Seger R, Schmid W, Orkin SH. Gene deletion in a patient with chronic granulomatous disease and McLeod syndrome: fine mapping of the Xk gene locus. Blood. 1988 Jan; 71(1):252-5.
    View in: PubMed
  372. Dinauer MC, Orkin SH. Molecular genetics of chronic granulomatous disease. Immunodefic Rev. 1988; 1(1):55-69.
    View in: PubMed
  373. Orkin SH, Williams DA. Gene therapy of somatic cells: status and prospects. Prog Med Genet. 1988; 7:130-42.
    View in: PubMed
  374. Brockdorff N, Fisher EM, Orkin SH, Lyon MF, Brown SD. Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution. Cytogenet Cell Genet. 1988; 48(2):124-5.
    View in: PubMed
  375. Wojchowski DM, Orkin SH, Sytkowski AJ. Active human erythropoietin expressed in insect cells using a baculovirus vector: a role for N-linked oligosaccharide. Biochim Biophys Acta. 1987 Dec 8; 910(3):224-32.
    View in: PubMed
  376. Orkin SH. Genetic diagnosis by DNA analysis: progress through amplification. N Engl J Med. 1987 Oct 15; 317(16):1023-5.
    View in: PubMed
  377. Ezekowitz RA, Orkin SH, Newburger PE. Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. J Clin Invest. 1987 Oct; 80(4):1009-16.
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  378. Lim B, Williams DA, Orkin SH. Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo. Mol Cell Biol. 1987 Oct; 7(10):3459-65.
    View in: PubMed
  379. Vogelstein B, Fearon ER, Hamilton SR, Preisinger AC, Willard HF, Michelson AM, Riggs AD, Orkin SH. Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Res. 1987 Sep 15; 47(18):4806-13.
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  380. Olivieri NF, Chang LS, Poon AO, Michelson AM, Orkin SH. An alpha-globin gene initiation codon mutation in a black family with HbH disease. Blood. 1987 Sep; 70(3):729-32.
    View in: PubMed
  381. Miller BA, Salameh M, Ahmed M, Olivieri N, Antognetti G, Orkin SH, Huisman TH, Nathan DG. Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia. Blood. 1987 Sep; 70(3):716-20.
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  382. Collins T, Bonthron DT, Orkin SH. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain. Nature. 1987 Aug 13-19; 328(6131):621-4.
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  383. Dinauer MC, Orkin SH, Brown R, Jesaitis AJ, Parkos CA. The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex. Nature. 1987 Jun 25-Jul 1; 327(6124):717-20.
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  384. Miller BA, Olivieri N, Salameh M, Ahmed M, Antognetti G, Huisman TH, Nathan DG, Orkin SH. Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. N Engl J Med. 1987 Jan 29; 316(5):244-50.
    View in: PubMed
  385. Miller BA, Salameh M, Ahmed M, Olivieri N, Huisman TH, Orkin SH, Nathan DG. Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia. Prog Clin Biol Res. 1987; 251:415-26.
    View in: PubMed
  386. Williams DA, Lim B, Orkin SH. Transfer and expression of human ADA in murine hematopoietic stem cells. Prog Clin Biol Res. 1987; 251:567-80.
    View in: PubMed
  387. Orkin SH. "Forward" and "reverse" genetics of inherited human disorders: the thalassemia syndromes and chronic granulomatous disease. Harvey Lect. 1987-1988; 83:57-76.
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  388. Orkin SH. Reverse genetics and human disease. Cell. 1986 Dec 26; 47(6):845-50.
    View in: PubMed
  389. Bonthron DT, Handin RI, Kaufman RJ, Wasley LC, Orr EC, Mitsock LM, Ewenstein B, Loscalzo J, Ginsburg D, Orkin SH. Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Nature. 1986 Nov 20-26; 324(6094):270-3.
    View in: PubMed
  390. Kwiatkowski DJ, Stossel TP, Orkin SH, Mole JE, Colten HR, Yin HL. Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature. 1986 Oct 2-8; 323(6087):455-8.
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  391. Bonthron D, Orr EC, Mitsock LM, Ginsburg D, Handin RI, Orkin SH. Nucleotide sequence of pre-pro-von Willebrand factor cDNA. Nucleic Acids Res. 1986 Sep 11; 14(17):7125-7.
    View in: PubMed
  392. Wong C, Antonarakis SE, Goff SC, Orkin SH, Boehm CD, Kazazian HH. On the origin and spread of beta-thalassemia: recurrent observation of four mutations in different ethnic groups. Proc Natl Acad Sci U S A. 1986 Sep; 83(17):6529-32.
    View in: PubMed
  393. Orkin SH. Molecular genetics and potential gene therapy. Clin Immunol Immunopathol. 1986 Jul; 40(1):151-6.
    View in: PubMed
  394. Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH. Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature. 1986 Jul 3-9; 322(6074):32-8.
    View in: PubMed
  395. Kazazian HH, Orkin SH, Boehm CD, Goff SC, Wong C, Dowling CE, Newburger PE, Knowlton RG, Brown V, Donis-Keller H. Characterization of a spontaneous mutation to a beta-thalassemia allele. Am J Hum Genet. 1986 Jun; 38(6):860-7.
    View in: PubMed
  396. Fay PJ, Kawai Y, Wagner DD, Ginsburg D, Bonthron D, Ohlsson-Wilhelm BM, Chavin SI, Abraham GN, Handin RI, Orkin SH, et al. Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. Science. 1986 May 23; 232(4753):995-8.
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  397. Miller BA, Salameh M, Ahmed M, Wainscoat J, Antognetti G, Orkin S, Weatherall D, Nathan DG. High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. Blood. 1986 May; 67(5):1404-10.
    View in: PubMed
  398. van den Elsen P, Georgopoulos K, Shepley BA, Orkin S, Terhorst C. Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. Proc Natl Acad Sci U S A. 1986 May; 83(9):2944-8.
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  399. Baehner RL, Kunkel LM, Monaco AP, Haines JL, Conneally PM, Palmer C, Heerema N, Orkin SH. DNA linkage analysis of X chromosome-linked chronic granulomatous disease. Proc Natl Acad Sci U S A. 1986 May; 83(10):3398-401.
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  400. Williams DA, Orkin SH. Somatic gene therapy. Current status and future prospects. J Clin Invest. 1986 Apr; 77(4):1053-6.
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  401. Williams DA, Orkin SH, Mulligan RC. Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2566-70.
    View in: PubMed
  402. Groopman JE, Sullivan JL, Mulder C, Ginsburg D, Orkin SH, O'Hara CJ, Falchuk K, Wong-Staal F, Gallo RC. Pathogenesis of B cell lymphoma in a patient with AIDS. Blood. 1986 Mar; 67(3):612-5.
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  403. Daddona PE, Orkin SH, Kelley WN. Expression defects of mutant human adenosine deaminase. Adv Exp Med Biol. 1986; 195 Pt A:217-22.
    View in: PubMed
  404. Ma NS, Gerhard DS, Housman DE, Orkin S, Bruns G. Owl monkey gene mapping: the assignment of gene loci for catalase, beta-globin gene cluster, HRAS1, insulin, and parathyroid hormone. Cytogenet Cell Genet. 1986; 43(1-2):57-68.
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  405. Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH. Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:177-83.
    View in: PubMed
  406. Horányi M, Földi J, Szelényi JG, Hollán SR, István L, Orkin SH. First occurrence of Hb H in Hungary. Haematologia (Budap). 1986; 19(3):193-5.
    View in: PubMed
  407. Erickson RP, Michelson AM, Rosenberg MP, Sánchez E, Orkin SH. Post-meiotic transcription of phosphoglycerate-kinase 2 in mouse testes. Biosci Rep. 1985 Dec; 5(12):1087-91.
    View in: PubMed
  408. Antin JH, Ginsburg D, Smith BR, Nathan DG, Orkin SH, Rappeport JM. Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. Blood. 1985 Dec; 66(6):1247-50.
    View in: PubMed
  409. Michelson AM, Blake CC, Evans ST, Orkin SH. Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain. Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6965-9.
    View in: PubMed
  410. Prochownik EV, Bock SC, Orkin SH. Intron structure of the human antithrombin III gene differs from that of other members of the serine protease inhibitor superfamily. J Biol Chem. 1985 Aug 15; 260(17):9608-12.
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  411. Bonthron DT, Markham AF, Ginsburg D, Orkin SH. Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency. J Clin Invest. 1985 Aug; 76(2):894-7.
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  412. Collins T, Ginsburg D, Boss JM, Orkin SH, Pober JS. Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Nature. 1985 Aug 22-28; 316(6030):748-50.
    View in: PubMed
  413. Ginsburg D, Handin RI, Bonthron DT, Donlon TA, Bruns GA, Latt SA, Orkin SH. Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization. Science. 1985 Jun 21; 228(4706):1401-6.
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  414. Michelson AM, Bruns GA, Morton CC, Orkin SH. The human phosphoglycerate kinase multigene family. HLA-associated sequences and an X-linked locus containing a processed pseudogene and its functional counterpart. J Biol Chem. 1985 Jun 10; 260(11):6982-92.
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  415. Ault KA, Antin JH, Ginsburg D, Orkin SH, Rappeport JM, Keohan ML, Martin P, Smith BR. Phenotype of recovering lymphoid cell populations after marrow transplantation. J Exp Med. 1985 Jun 1; 161(6):1483-502.
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  416. van den Elsen P, Bruns G, Gerhard DS, Pravtcheva D, Jones C, Housman D, Ruddle FA, Orkin S, Terhorst C. Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9. Proc Natl Acad Sci U S A. 1985 May; 82(9):2920-4.
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  417. Orkin SH, Goff SC, Kelley WN, Daddona PE. Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution. Mol Cell Biol. 1985 Apr; 5(4):762-7.
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  418. Ginsburg D, Antin JH, Smith BR, Orkin SH, Rappeport JM. Origin of cell populations after bone marrow transplantation. Analysis using DNA sequence polymorphisms. J Clin Invest. 1985 Feb; 75(2):596-603.
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  419. Orkin SH, Cheng TC, Antonarakis SE, Kazazian HH. Thalassemia due to a mutation in the cleavage-polyadenylation signal of the human beta-globin gene. EMBO J. 1985 Feb; 4(2):453-6.
    View in: PubMed
  420. Antonarakis SE, Kazazian HH, Orkin SH. DNA polymorphism and molecular pathology of the human globin gene clusters. Hum Genet. 1985; 69(1):1-14.
    View in: PubMed
  421. Daddona PE, Orkin SH, Shewach DS, Kelley WN. cDNA and amino acid sequence of human adenosine deaminase. Ann N Y Acad Sci. 1985; 451:238-44.
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  422. Prochownik EV, Orkin SH. In vivo transcription of a human antithrombin III "minigene". J Biol Chem. 1984 Dec 25; 259(24):15386-92.
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  423. Huebner K, Nagarajan L, deJesus E, Orkin SH, Caskey CT, Croce CM. Activity of X-linked genes in stem and differentiated Mus musculus X Mus caroli hybrid cells. Cell Differ. 1984 Dec; 15(2-4):241-8.
    View in: PubMed
  424. van den Elsen P, Shepley BA, Borst J, Coligan JE, Markham AF, Orkin S, Terhorst C. Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. Nature. 1984 Nov 29-Dec 5; 312(5993):413-8.
    View in: PubMed
  425. Daddona PE, Shewach DS, Kelley WN, Argos P, Markham AF, Orkin SH. Human adenosine deaminase. cDNA and complete primary amino acid sequence. J Biol Chem. 1984 Oct 10; 259(19):12101-6.
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  426. Orkin SH. Molecular analysis of human disease: dissection of beta-thalassemia. Clin Res. 1984 Sep; 32(3):329-33.
    View in: PubMed
  427. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest. 1984 Aug; 74(2):652-6.
    View in: PubMed
  428. Orkin SH, Antonarakis SE, Kazazian HH. Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC. J Biol Chem. 1984 Jul 25; 259(14):8679-81.
    View in: PubMed
  429. Kazazian HH, Orkin SH, Markham AF, Chapman CR, Youssoufian H, Waber PG. Quantification of the close association between DNA haplotypes and specific beta-thalassaemia mutations in Mediterraneans. Nature. 1984 Jul 12-18; 310(5973):152-4.
    View in: PubMed
  430. Orkin SH, Antonarakis SE, Loukopoulos D. Abnormal processing of beta Knossos RNA. Blood. 1984 Jul; 64(1):311-3.
    View in: PubMed
  431. Weinberg RS, Antonarakis SE, Kazazian HH, Dover GJ, Orkin SH, Lenes AL, Schofield JM, Alter BP. Fetal hemoglobin synthesis in erythroid cultures in hereditary persistence of fetal hemoglobin and beta o-thalassemia. Blood. 1984 Jun; 63(6):1278-84.
    View in: PubMed
  432. Cheng TC, Orkin SH, Antonarakis SE, Potter MJ, Sexton JP, Markham AF, Giardina PJ, Li A, Kazazian HH. beta-Thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects. Proc Natl Acad Sci U S A. 1984 May; 81(9):2821-5.
    View in: PubMed
  433. Morton CC, Kirsch IR, Taub R, Orkin SH, Brown JA. Localization of the beta-globin gene by chromosomal in situ hybridization. Am J Hum Genet. 1984 May; 36(3):576-85.
    View in: PubMed
  434. Orkin SH, Goldman DS, Sallan SE. Development of homozygosity for chromosome 11p markers in Wilms' tumour. Nature. 1984 May 10-16; 309(5964):172-4.
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  435. Kazazian HH, Orkin SH, Antonarakis SE, Sexton JP, Boehm CD, Goff SC, Waber PG. Molecular characterization of seven beta-thalassemia mutations in Asian Indians. EMBO J. 1984 Mar; 3(3):593-6.
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  436. Orkin SH. Prenatal diagnosis of hemoglobin disorders by DNA analysis. Blood. 1984 Feb; 63(2):249-53.
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  437. Orkin SH, Kazazian HH. The mutation and polymorphism of the human beta-globin gene and its surrounding DNA. Annu Rev Genet. 1984; 18:131-71.
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  438. Hutz MH, Michelson AM, Antonarakis SE, Orkin SH, Kazazian HH. Restriction site polymorphism in the phosphoglycerate kinase gene on the X chromosome. Hum Genet. 1984; 66(2-3):217-9.
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  439. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. Trans Assoc Am Physicians. 1984; 97:268-74.
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  440. Michelson AM, Orkin SH. Boundaries of gene conversion within the duplicated human alpha-globin genes. Concerted evolution by segmental recombination. J Biol Chem. 1983 Dec 25; 258(24):15245-54.
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  441. Orkin SH, Daddona PE, Shewach DS, Markham AF, Bruns GA, Goff SC, Kelley WN. Molecular cloning of human adenosine deaminase gene sequences. J Biol Chem. 1983 Nov 10; 258(21):12753-6.
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  442. Kazazian HH, Orkin SH, Boehm CD, Sexton JP, Antonarakis SE. beta-Thalassemia due to a deletion of the nucleotide which is substituted in the beta S-globin gene. Am J Hum Genet. 1983 Sep; 35(5):1028-33.
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  443. Orkin SH, Sexton JP, Cheng TC, Goff SC, Giardina PJ, Lee JI, Kazazian HH. ATA box transcription mutation in beta-thalassemia. Nucleic Acids Res. 1983 Jul 25; 11(14):4727-34.
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  444. Prochownik EV, Markham AF, Orkin SH. Isolation of a cDNA clone for human antithrombin III. J Biol Chem. 1983 Jul 10; 258(13):8389-94.
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  445. Schwaber J, Molgaard H, Orkin SH, Gould HJ, Rosen FS. Early pre-B cells from normal and X-linked agammaglobulinaemia produce C mu without an attached VH region. Nature. 1983 Jul 28-Aug 3; 304(5924):355-8.
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  446. Prochownik EV, Antonarakis S, Bauer KA, Rosenberg RD, Fearon ER, Orkin SH. Molecular heterogeneity of inherited antithrombin III deficiency. N Engl J Med. 1983 Jun 30; 308(26):1549-52.
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  447. Orkin SH, Sexton JP, Goff SC, Kazazian HH. Inactivation of an acceptor RNA splice site by a short deletion in beta-thalassemia. J Biol Chem. 1983 Jun 25; 258(12):7249-51.
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  448. Wainscoat JS, Old JM, Weatherall DJ, Orkin SH. The molecular basis for the clinical diversity of beta thalassaemia in Cypriots. Lancet. 1983 Jun 4; 1(8336):1235-7.
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  449. Fearon ER, Kazazian HH, Waber PG, Lee JI, Antonarakis SE, Orkin SH, Vanin EF, Henthorn PS, Grosveld FG, Scott AF, Buchanan GR. The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia. Blood. 1983 Jun; 61(6):1269-74.
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  450. Treisman R, Orkin SH, Maniatis T. Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature. 1983 Apr 14; 302(5909):591-6.
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  451. Orkin SH, Markham AF, Kazazian HH. Direct detection of the common Mediterranean beta-thalassemia gene with synthetic DNA probes. An alternative approach for prenatal diagnosis. J Clin Invest. 1983 Mar; 71(3):775-9.
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  452. Orkin SH. Controlling the fetal globin switch in man. Nature. 1983 Jan 13; 301(5896):108-9.
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  453. Dryja TP, Bruns GA, Orkin SH, Albert DM, Gerald PS. Isolation of DNA fragments from chromosome 13. Retina. 1983; 3(2):121-5.
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  454. Orkin SH, Antonarakis SE, Kazazian HH. Polymorphism and molecular pathology of the human beta-globin gene. Prog Hematol. 1983; 13:49-73.
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  455. Treisman R, Orkin SH, Maniatis T. Structural and functional defects in beta-thalassemia. Prog Clin Biol Res. 1983; 134:99-121.
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  456. Michelson AM, Markham AF, Orkin SH. Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase. Proc Natl Acad Sci U S A. 1983 Jan; 80(2):472-6.
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  457. Michelson AM, Orkin SH. Characterization of the homopolymer tailing reaction catalyzed by terminal deoxynucleotidyl transferase. Implications for the cloning of cDNA. J Biol Chem. 1982 Dec 25; 257(24):14773-82.
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  458. Orkin SH, Kazazian HH, Antonarakis SE, Ostrer H, Goff SC, Sexton JP. Abnormal RNA processing due to the exon mutation of beta E-globin gene. Nature. 1982 Dec 23; 300(5894):768-9.
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  459. Spritz RA, Orkin SH. Duplication followed by deletion accounts for the structure of an Indian deletion beta (0)-thalassemia gene. Nucleic Acids Res. 1982 Dec 20; 10(24):8025-9.
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  460. Antonarakis SE, Orkin SH, Kazazian HH, Goff SC, Boehm CD, Waber PG, Sexton JP, Ostrer H, Fairbanks VF, Chakravarti A. Evidence for multiple origins of the beta E-globin gene in Southeast Asia. Proc Natl Acad Sci U S A. 1982 Nov; 79(21):6608-11.
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  461. Orkin SH, Little PF, Kazazian HH, Boehm CD. Improved detection of the sickle mutation by DNA analysis: application to prenatal diagnosis. N Engl J Med. 1982 Jul 1; 307(1):32-6.
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  462. Felber BK, Orkin SH, Hamer DH. Abnormal RNA splicing causes one form of alpha thalassemia. Cell. 1982 Jul; 29(3):895-902.
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  463. Orkin SH, Kazazian HH, Antonarakis SE, Goff SC, Boehm CD, Sexton JP, Waber PG, Giardina PJ. Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster. Nature. 1982 Apr 15; 296(5858):627-31.
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  464. Orkin SH. Genetic diagnosis of the fetus. Nature. 1982 Mar 18; 296(5854):202-3.
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  465. Disteche CM, Kunkel LM, Lojewski A, Orkin SH, Eisenhard M, Sahar E, Travis B, Latt SA. Isolation of mouse x-chromosome specific DNA from an x-enriched lambda phage library derived from flow sorted chromosomes. Cytometry. 1982 Mar; 2(5):282-6.
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  466. Kurnit D, Orkin S, White R. Prenatal analysis of human DNA-sequence variation. Methods Cell Biol. 1982; 26:311-30.
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  467. Orkin SH, Goff SC. Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes. J Biol Chem. 1981 Oct 10; 256(19):9782-4.
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  468. Orkin SH, Goff SC, Hechtman RL. Mutation in an intervening sequence splice junction in man. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):5041-5.
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  469. Orkin SH, Goff SC. The duplicated human alpha-globin genes: their relative expression as measured by RNA analysis. Cell. 1981 May; 24(2):345-51.
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  470. Orkin SH, Goff SC, Nathan DG. Heterogeneity of DNA deletion in gamma delta beta-thalassemia. J Clin Invest. 1981 Mar; 67(3):878-84.
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  471. Orkin SH, Nathan DG. The molecular genetics of thalassemia. Adv Hum Genet. 1981; 11:233-80.
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  472. Michelson AM, Orkin SH. The 3' untranslated regions of the duplicated human alpha-globin genes are unexpectedly divergent. Cell. 1980 Nov; 22(2 Pt 2):371-7.
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  473. Orkin SH, Michelson A. Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia. Nature. 1980 Jul 31; 286(5772):538-40.
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  474. Orkin SH, Kolodner R, Michelson A, Husson R. Cloning and direct examination of a structurally abnormal human beta 0-thalassemia globin gene. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3558-62.
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  475. Orkin SH. Specific abnormalities of globin gene organization in the thalassemia syndromes. Ann N Y Acad Sci. 1980; 344:48-61.
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  476. Alter BP, Orkin SH, Forget BG, Nathan DG. Prenatal diagnosis of hemoglobinopathies: the New England approach. Ann N Y Acad Sci. 1980; 344:151-64.
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  477. Orkin SH. The alpha thalassemias. Tex Rep Biol Med. 1980-1981; 40:335-42.
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  478. Gusella J, Varsanyi-Breiner A, Kao FT, Jones C, Puck TT, Keys C, Orkin S, Housman D. Precise localization of human beta-globin gene complex on chromosome 11. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5239-42.
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  479. Nathan DG, Alter BP, Orkin SH. Prenatal diagnosis of hemoglobinopathies. Clin Perinatol. 1979 Sep; 6(2):275-91.
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  480. Orkin SH, Alter BP, Altay C. Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia. J Clin Invest. 1979 Sep; 64(3):866-9.
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  481. Orkin SH, Old J, Lazarus H, Altay C, Gurgey A, Weatherall DJ, Nathan DG. The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. 1979 May; 17(1):33-42.
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  482. Orkin SH, Old JM, Weatherall DJ, Nathan DG. Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. Proc Natl Acad Sci U S A. 1979 May; 76(5):2400-4.
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  483. Orkin SH. The duplicated human alpha globin genes lie close together in cellular DNA. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5950-4.
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  484. Orkin SH, Alter BP, Altay C, Mahoney MJ, Lazarus H, Hobbins JC, Nathan DG. Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. N Engl J Med. 1978 Jul 27; 299(4):166-72.
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  485. Orkin SH. Fidelity of globin ribonucleic acid synthesis in vitro by isolated nuclei: asymmetric gene expression. Biochemistry. 1978 Feb 7; 17(3):487-92.
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  486. Orkin SH. Selective restriction endonuclease cleavage of human globin genes. J Biol Chem. 1978 Jan 10; 253(1):12-5.
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  487. Orkin SH. Differentiation of murine erythroleukemic (Friend) cells: an in vitro model of erythropoiesis. In Vitro. 1978 Jan; 14(1):146-54.
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  488. Orkin SH. In vitro synthesis of a DNA probe for antisense globin sequences. J Biol Chem. 1977 Aug 25; 252(16):5606-8.
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  489. Orkin SH, Swerdlow PS. Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: direct evidence for increased transcription during erythroid differentiation. Proc Natl Acad Sci U S A. 1977 Jun; 74(6):2475-9.
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  490. Orkin SH, Nathan DG. The thalassemias. N Engl J Med. 1976 Sep 23; 295(13):710-4.
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  491. Orkin SH, Nathan DG. The molecular genetics of thalassemia. Birth Defects Orig Artic Ser. 1976; 12(8):145-59.
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  492. Littlefield JW, Chang SE, Hänggi UJ, Nakamura H, Orkin SH. Studies on the overproduction of dihydrofolate reductase by variant hamster cells in culture. Adv Enzyme Regul. 1976; 15:301-17.
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  493. Leder A, Orkin S, Leder P. Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis. Science. 1975 Nov 28; 190(4217):893-4.
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  494. Orkin SH, Swan D, Leder P. Differential expression of alpha- and beta-globin genes during differentiation of cultured erythroleukemic cells. J Biol Chem. 1975 Nov 25; 250(22):8753-60.
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  495. Orkin SH, Harosi FI, Leder P. Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci U S A. 1975 Jan; 72(1):98-102.
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  496. Orkin SH, Buchanan PD, Yount WJ, Reisner H, Littlefield JW. Lambda-chain production in human lymphoblast-mouse fibroblast hybrids. Proc Natl Acad Sci U S A. 1973 Aug; 70(8):2401-5.
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  497. Orkin SH, Littlefield JW. Mutagenesis to aminopterin resistance in cultured hamster cells. Exp Cell Res. 1971 Nov; 69(1):174-80.
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  498. Dowben RM, Orkin SH. Extrinsic cotton effects in dye-bovine plasma albumin adducts. Proc Natl Acad Sci U S A. 1967 Nov; 58(5):2051-4.
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