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Vadim Bolshakov, Ph.D.

TitleProfessor of Psychiatry
InstitutionMcLean Hospital
DepartmentPsychiatry
AddressMclean Hospital
Cellular Neurobio Lab - Mrc II
115 Mill St
Belmont MA 02478
Phone617/855-3171
Fax617/855-2023

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cho JH, Deisseroth K, Bolshakov VY. Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits. Neuron. 2013 Dec 18; 80(6):1491-507.
    View in: PubMed
  2. Balu DT, Li Y, Puhl MD, Benneyworth MA, Basu AC, Takagi S, Bolshakov VY, Coyle JT. Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2400-9.
    View in: PubMed
  3. Li Y, Sacchi S, Pollegioni L, Basu AC, Coyle JT, Bolshakov VY. Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level. Nat Commun. 2013 Apr 23; 4:1760.
    View in: PubMed
  4. Li Y, Meloni EG, Carlezon WA, Milad MR, Pitman RK, Nader K, Bolshakov VY. Learning and reconsolidation implicate different synaptic mechanisms. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4798-803.
    View in: PubMed
  5. Cho JH, Zushida K, Shumyatsky GP, Carlezon WA, Meloni EG, Bolshakov VY. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci. 2012 Oct 10; 32(41):14165-77.
    View in: PubMed
  6. Gisabella B, Bolshakov VY, Benes FM. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012; 7(3):e32483.
    View in: PubMed
  7. Benneyworth MA, Li Y, Basu AC, Bolshakov VY, Coyle JT. Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons. Cell Mol Neurobiol. 2012 May; 32(4):613-24.
    View in: PubMed
  8. Cho JH, Bayazitov IT, Meloni EG, Myers KM, Carlezon WA, Zakharenko SS, Bolshakov VY. Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdala. Nat Neurosci. 2012 Jan; 15(1):113-22.
    View in: PubMed
  9. Chung S, Moon JI, Leung A, Aldrich D, Lukianov S, Kitayama Y, Park S, Li Y, Bolshakov VY, Lamonerie T, Kim KS. ES cell-derived renewable and functional midbrain dopaminergic progenitors. Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23):9703-8.
    View in: PubMed
  10. Shin RM, Tully K, Li Y, Cho JH, Higuchi M, Suhara T, Bolshakov VY. Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala. Proc Natl Acad Sci U S A. 2010 Nov 2; 107(44):19073-8.
    View in: PubMed
  11. Tully K, Bolshakov VY. Emotional enhancement of memory: how norepinephrine enables synaptic plasticity. Mol Brain. 2010; 3:15.
    View in: PubMed
  12. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72.
    View in: PubMed
  13. Li Y, Krupa B, Kang JS, Bolshakov VY, Liu G. Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns. J Neurophysiol. 2009 Jul; 102(1):578-89.
    View in: PubMed
  14. Bolshakov VY. Nipping fear in the bud: inhibitory control in the amygdala. Neuron. 2009 Mar 26; 61(6):817-9.
    View in: PubMed
  15. Gisabella B, Cunningham MG, Bolshakov VY, Benes FM. Amygdala-dependent regulation of electrical properties of hippocampal interneurons in a model of schizophrenia. Biol Psychiatry. 2009 Mar 15; 65(6):464-72.
    View in: PubMed
  16. Pan BX, Vautier F, Ito W, Bolshakov VY, Morozov A. Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci. 2008 Feb 27; 28(9):2089-98.
    View in: PubMed
  17. Tully K, Li Y, Bolshakov VY. Keeping in check painful synapses in central amygdala. Neuron. 2007 Dec 6; 56(5):757-9.
    View in: PubMed
  18. Tully K, Li Y, Tsvetkov E, Bolshakov VY. Norepinephrine enables the induction of associative long-term potentiation at thalamo-amygdala synapses. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14146-50.
    View in: PubMed
  19. Bolshakov VY. SCOPing out proteases in long-term memory. Cell. 2007 Mar 23; 128(6):1029-30.
    View in: PubMed
  20. Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, Jia Z, Kaang BK, Kawamata M, Kida S, Klann E, Kohno T, Li M, Li XJ, MacDonald JF, Nader K, Nguyen PV, Oh U, Ren K, Roder JC, Salter MW, Song W, Sugita S, Tang SJ, Tao Y, Wang YT, Woo N, Woodin MA, Yan Z, Yoshimura M, Xu M, Xu ZC, Zhang X, Zhen M, Zhuo M. Recent advances in basic neurosciences and brain disease: from synapses to behavior. Mol Pain. 2006; 2:38.
    View in: PubMed
  21. Shin RM, Tsvetkov E, Bolshakov VY. Spatiotemporal asymmetry of associative synaptic plasticity in fear conditioning pathways. Neuron. 2006 Dec 7; 52(5):883-96.
    View in: PubMed
  22. Kodirov SA, Takizawa S, Joseph J, Kandel ER, Shumyatsky GP, Bolshakov VY. Synaptically released zinc gates long-term potentiation in fear conditioning pathways. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15218-23.
    View in: PubMed
  23. Goussakov I, Chartoff EH, Tsvetkov E, Gerety LP, Meloni EG, Carlezon WA, Bolshakov VY. LTP in the lateral amygdala during cocaine withdrawal. Eur J Neurosci. 2006 Jan; 23(1):239-50.
    View in: PubMed
  24. Shumyatsky GP, Malleret G, Shin RM, Takizawa S, Tully K, Tsvetkov E, Zakharenko SS, Joseph J, Vronskaya S, Yin D, Schubart UK, Kandel ER, Bolshakov VY. stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell. 2005 Nov 18; 123(4):697-709.
    View in: PubMed
  25. Gisabella B, Bolshakov VY, Benes FM. Regulation of synaptic plasticity in a schizophrenia model. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13301-6.
    View in: PubMed
  26. Dityatev AE, Bolshakov VY. Amygdala, long-term potentiation, and fear conditioning. Neuroscientist. 2005 Feb; 11(1):75-88.
    View in: PubMed
  27. Tsvetkov E, Shin RM, Bolshakov VY. Glutamate uptake determines pathway specificity of long-term potentiation in the neural circuitry of fear conditioning. Neuron. 2004 Jan 8; 41(1):139-51.
    View in: PubMed
  28. Feinmark SJ, Begum R, Tsvetkov E, Goussakov I, Funk CD, Siegelbaum SA, Bolshakov VY. 12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses. J Neurosci. 2003 Dec 10; 23(36):11427-35.
    View in: PubMed
  29. Hinds HL, Goussakov I, Nakazawa K, Tonegawa S, Bolshakov VY. Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7):4275-80.
    View in: PubMed
  30. Shumyatsky GP, Tsvetkov E, Malleret G, Vronskaya S, Hatton M, Hampton L, Battey JF, Dulac C, Kandel ER, Bolshakov VY. Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell. 2002 Dec 13; 111(6):905-18.
    View in: PubMed
  31. Tsvetkov E, Carlezon WA, Benes FM, Kandel ER, Bolshakov VY. Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala. Neuron. 2002 Apr 11; 34(2):289-300.
    View in: PubMed
  32. Bolshakov VY, Carboni L, Cobb MH, Siegelbaum SA, Belardetti F. Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. Nat Neurosci. 2000 Nov; 3(11):1107-12.
    View in: PubMed
  33. Janz R, Südhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron. 1999 Nov; 24(3):687-700.
    View in: PubMed
  34. Bolshakov VY, Golan H, Kandel ER, Siegelbaum SA. Recruitment of new sites of synaptic transmission during the cAMP-dependent late phase of LTP at CA3-CA1 synapses in the hippocampus. Neuron. 1997 Sep; 19(3):635-51.
    View in: PubMed
  35. McMahon HT, Bolshakov VY, Janz R, Hammer RE, Siegelbaum SA, Südhof TC. Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4760-4.
    View in: PubMed
  36. Siegelbaum SA, Bolshakov VY. Response: Long-Term Potentiation in the CA1 Hippocampus. Science. 1996 Mar 15; 271(5255):1605-6.
    View in: PubMed
  37. Bolshakov VY, Siegelbaum SA. Hippocampal long-term depression: arachidonic acid as a potential retrograde messenger. Neuropharmacology. 1995 Nov; 34(11):1581-7.
    View in: PubMed
  38. Bolshakov VY, Siegelbaum SA. Regulation of hippocampal transmitter release during development and long-term potentiation. Science. 1995 Sep 22; 269(5231):1730-4.
    View in: PubMed
  39. Geppert M, Bolshakov VY, Siegelbaum SA, Takei K, De Camilli P, Hammer RE, Südhof TC. The role of Rab3A in neurotransmitter release. Nature. 1994 Jun 9; 369(6480):493-7.
    View in: PubMed
  40. Bolshakov VY, Siegelbaum SA. Postsynaptic induction and presynaptic expression of hippocampal long-term depression. Science. 1994 May 20; 264(5162):1148-52.
    View in: PubMed
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