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Alexander John McAdam, M.D., Ph.D.

TitleAssociate Professor of Pathology
InstitutionChildren's Hospital Boston
DepartmentPathology
AddressChildrens Hospital
Laboratory Medicine
300 Longwood Ave
Boston MA 02115
Phone617/355-5754

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sandora TJ, Gerner-Smidt P, McAdam AJ. What's Your Subtype? The Epidemiologic Utility of Bacterial Whole-Genome Sequencing. Clin Chem. 2014 Jan 7.
    View in: PubMed
  2. Lieberman TD, Flett KB, Yelin I, Martin TR, McAdam AJ, Priebe GP, Kishony R. Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures. Nat Genet. 2014 Jan; 46(1):82-7.
    View in: PubMed
  3. Youngster I, Sharma TS, Duncan CN, McAdam AJ. Yield of fungal surveillance cultures in pediatric hematopoietic stem cell transplant patients: a retrospective analysis and survey of current practice. Clin Infect Dis. 2014 Feb; 58(3):365-71.
    View in: PubMed
  4. Pollock NR, McAdam AJ, Pai M, Nardell EA, Bernardo J, Banaei N, Mobo J. Interferon ?-Release Assays for Diagnosis of Latent Tuberculosis in Healthcare Workers in Low-Incidence Settings: Pros and Cons. Clin Chem. 2013 Oct 7.
    View in: PubMed
  5. Lamousé-Smith ES, Weber S, Rossi RF, Neinstedt LJ, Mosammaparast N, Sandora TJ, McAdam AJ, Bousvaros A. Polymerase Chain Reaction Test for Clostridium difficile Toxin B Gene Reveals Similar Prevalence Rates in Children With and Without Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2013 Sep; 57(3):293-7.
    View in: PubMed
  6. Biographical feature: Eileen L. Randall, Ph.D. J Clin Microbiol. 2013 Nov; 51(11):3476-7.
    View in: PubMed
  7. Sandora TJ, Dolan SA, Harbarth S, Huang SS, McAdam AJ, Milstone AM. Identifying antibiotic-resistant bacteria in hospitalized patients: what is the role of active-surveillance cultures? Clin Chem. 2013 Nov; 59(11):1556-60.
    View in: PubMed
  8. Hermos CR, Sandora TJ, Williams LE, Mosammaparast N, McAdam AJ. Changing epidemiology of methicillin-resistant Staphylococcus aureus colonization in paediatric intensive-care units. Epidemiol Infect. 2013 Sep; 141(9):1983-92.
    View in: PubMed
  9. Flett K, Youngster I, Huang J, McAdam A, Sandora TJ, Rennick M, Smole S, Rogers SL, Nix WA, Oberste MS, Gellis S, Ahmed AA. Hand, foot, and mouth disease caused by coxsackievirus a6. Emerg Infect Dis. 2012 Oct; 18(10):1702-4.
    View in: PubMed
  10. McAdam AJ. John C. Sherris, m.d. J Clin Microbiol. 2012 Nov; 50(11):3416-7.
    View in: PubMed
  11. Mansbach JM, Piedra PA, Laham FR, McAdam AJ, Clark S, Sullivan AF, Camargo CA. Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter emergency department study. Pediatr Infect Dis J. 2012 Jul; 31(7):767-9.
    View in: PubMed
  12. Hooper DC, DeMaria A, Limbago BM, O'Brien TF, McCaughey B. Antibiotic resistance: how serious is the problem, and what can be done? Clin Chem. 2012 Aug; 58(8):1182-6.
    View in: PubMed
  13. Lyons TW, McAdam AJ, Cohn KA, Monuteaux MC, Nigrovic LE. Impact of in-hospital enteroviral polymerase chain reaction testing on the clinical management of children with meningitis. J Hosp Med. 2012 Sep; 7(7):517-20.
    View in: PubMed
  14. Sandora TJ, McAdam AJ. Photo quiz: an 11-year-old with abdominal pain. J Clin Microbiol. 2012 Apr; 50(4):1139, 1508.
    View in: PubMed
  15. Skurnik D, Davis MR, Benedetti D, Moravec KL, Cywes-Bentley C, Roux D, Traficante DC, Walsh RL, Maira-Litràn T, Cassidy SK, Hermos CR, Martin TR, Thakkallapalli EL, Vargas SO, McAdam AJ, Lieberman TD, Kishony R, Lipuma JJ, Pier GB, Goldberg JB, Priebe GP. Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. J Infect Dis. 2012 Jun; 205(11):1709-18.
    View in: PubMed
  16. Mosammaparast N, McAdam AJ, Nolte FS. Molecular testing for infectious diseases should be done in the clinical microbiology laboratory. J Clin Microbiol. 2012 Jun; 50(6):1836-40.
    View in: PubMed
  17. Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PI. A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. PLoS One. 2012; 7(2):e31307.
    View in: PubMed
  18. Lieberman TD, Michel JB, Aingaran M, Potter-Bynoe G, Roux D, Davis MR, Skurnik D, Leiby N, LiPuma JJ, Goldberg JB, McAdam AJ, Priebe GP, Kishony R. Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes. Nat Genet. 2011 Dec; 43(12):1275-80.
    View in: PubMed
  19. Mosammaparast N, Rossi RF, Smole S, McAdam AJ. Improved sensitivity of a commercial reverse transcription-PCR test for subtyping of the 2009 H1N1 influenza A virus. J Clin Microbiol. 2011 Mar; 49(3):1188.
    View in: PubMed
  20. Hermos CR, Janineh M, Han LL, McAdam AJ. Shiga toxin-producing Escherichia coli in children: diagnosis and clinical manifestations of O157:H7 and non-O157:H7 infection. J Clin Microbiol. 2011 Mar; 49(3):955-9.
    View in: PubMed
  21. Lee EY, Khatwa U, McAdam AJ, Bastos Md, Mahmood SA, Ervoes JP, Boiselle PM. Streptococcus milleri group pleuropulmonary infection in children: computed tomographic findings and clinical features. J Comput Assist Tomogr. 2010 Nov-Dec; 34(6):927-32.
    View in: PubMed
  22. Nakamura MM, McAdam AJ, Sandora TJ, Moreira KR, Lee GM. Higher prevalence of pharyngeal than nasal Staphylococcus aureus carriage in pediatric intensive care units. J Clin Microbiol. 2010 Aug; 48(8):2957-9.
    View in: PubMed
  23. Nguyen HT, Hurwitz RS, Defoor WR, Minevich E, McAdam AJ, Mortensen JE, Novak-Weekley SM, Minnillo BJ, Elder JS. Trimethoprim in vitro antibacterial activity is not increased by adding sulfamethoxazole for pediatric Escherichia coli urinary tract infection. J Urol. 2010 Jul; 184(1):305-10.
    View in: PubMed
  24. Ginocchio CC, Swierkosz E, McAdam AJ, Marcon M, Storch GA, Valsamakis A, Juretschko S, Romero J, Yen-Lieberman B. Multicenter study of clinical performance of the 3M Rapid Detection RSV test. J Clin Microbiol. 2010 Jul; 48(7):2337-43.
    View in: PubMed
  25. Regev-Yochay G, Hanage WP, Trzcinski K, Rifas-Shiman SL, Lee G, Bessolo A, Huang SS, Pelton SI, McAdam AJ, Finkelstein JA, Lipsitch M, Malley R. Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA. Vaccine. 2010 Jul 5; 28(30):4842-6.
    View in: PubMed
  26. Sandora TJ, Smole SC, Lee GM, Chung S, Williams L, McAdam AJ. Test characteristics of commercial influenza assays for detecting pandemic influenza A (H1N1) in children. Pediatr Infect Dis J. 2010 Mar; 29(3):261-2.
    View in: PubMed
  27. Hermos CR, Vargas SO, McAdam AJ. Human metapneumovirus. Clin Lab Med. 2010 Mar; 30(1):131-48.
    View in: PubMed
  28. Lee EY, McAdam AJ, Chaudry G, Fishman MP, Zurakowski D, Boiselle PM. Swine-origin influenza a (H1N1) viral infection in children: initial chest radiographic findings. Radiology. 2010 Mar; 254(3):934-41.
    View in: PubMed
  29. McAdam AJ, Riley AM. Developments in tissue culture detection of respiratory viruses. Clin Lab Med. 2009 Dec; 29(4):623-34.
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  30. McAdam AJ. Respiratory viruses in pediatric and adult populations. Preface. Clin Lab Med. 2009 Dec; 29(4):xi-xii.
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  31. Bourgeois FT, Valim C, McAdam AJ, Mandl KD. Relative impact of influenza and respiratory syncytial virus in young children. Pediatrics. 2009 Dec; 124(6):e1072-80.
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  32. Lee GM, Huang SS, Rifas-Shiman SL, Hinrichsen VL, Pelton SI, Kleinman K, Hanage WP, Lipsitch M, McAdam AJ, Finkelstein JA. Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era. BMC Infect Dis. 2009; 9:110.
    View in: PubMed
  33. Mansbach JM, McAdam AJ, Clark S, Hain PD, Flood RG, Acholonu U, Camargo CA. Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department. Acad Emerg Med. 2008 Feb; 15(2):111-8.
    View in: PubMed
  34. Basset A, Trzcinski K, Hermos C, O'Brien KL, Reid R, Santosham M, McAdam AJ, Lipsitch M, Malley R. Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence. J Clin Microbiol. 2007 Jun; 45(6):1684-9.
    View in: PubMed
  35. Bourgeois FT, Valim C, Wei JC, McAdam AJ, Mandl KD. Influenza and other respiratory virus-related emergency department visits among young children. Pediatrics. 2006 Jul; 118(1):e1-8.
    View in: PubMed
  36. Bourgeois FT, Olson KL, Brownstein JS, McAdam AJ, Mandl KD. Validation of syndromic surveillance for respiratory infections. Ann Emerg Med. 2006 Mar; 47(3):265.e1.
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  37. Kalish LA, Waltz DA, Dovey M, Potter-Bynoe G, McAdam AJ, Lipuma JJ, Gerard C, Goldmann D. Impact of Burkholderia dolosa on lung function and survival in cystic fibrosis. Am J Respir Crit Care Med. 2006 Feb 15; 173(4):421-5.
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  38. Nigrovic LE, Kuppermann N, McAdam AJ, Malley R. Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. Pediatr Infect Dis J. 2004 Aug; 23(8):786-8.
    View in: PubMed
  39. Vargas SO, Kozakewich HP, Perez-Atayde AR, McAdam AJ. Pathology of human metapneumovirus infection: insights into the pathogenesis of a newly identified respiratory virus. Pediatr Dev Pathol. 2004 Sep-Oct; 7(5):478-86; discussion 421.
    View in: PubMed
  40. McAdam AJ, Hasenbein ME, Feldman HA, Cole SE, Offermann JT, Riley AM, Lieu TA. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis. 2004 Jul 1; 190(1):20-6.
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  41. Hasenbein ME, Warner JE, Lambert KG, Cole SE, Onderdonk AB, McAdam AJ. Detection of multiple macrolide- and lincosamide-resistant strains of Streptococcus pyogenes from patients in the Boston area. J Clin Microbiol. 2004 Apr; 42(4):1559-63.
    View in: PubMed
  42. O'Brien MA, Uyeki TM, Shay DK, Thompson WW, Kleinman K, McAdam A, Yu XJ, Platt R, Lieu TA. Incidence of outpatient visits and hospitalizations related to influenza in infants and young children. Pediatrics. 2004 Mar; 113(3 Pt 1):585-93.
    View in: PubMed
  43. Heelan JS, Hasenbein ME, McAdam AJ. Resistance of group B streptococcus to selected antibiotics, including erythromycin and clindamycin. J Clin Microbiol. 2004 Mar; 42(3):1263-4.
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  44. McIntosh K, McAdam AJ. Human metapneumovirus--an important new respiratory virus. N Engl J Med. 2004 Jan 29; 350(5):431-3.
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  45. Greenwald RJ, McAdam AJ, Van der Woude D, Satoskar AR, Sharpe AH. Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis. J Immunol. 2002 Feb 1; 168(3):991-5.
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  46. McAdam AJ, Greenwald RJ, Levin MA, Chernova T, Malenkovich N, Ling V, Freeman GJ, Sharpe AH. ICOS is critical for CD40-mediated antibody class switching. Nature. 2001 Jan 4; 409(6816):102-5.
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  47. McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe AH, Freeman GJ. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol. 2000 Nov 1; 165(9):5035-40.
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  48. McAdam AJ, Gewurz BE, Farkash EA, Sharpe AH. Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL. J Immunol. 2000 Sep 15; 165(6):3088-93.
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  49. McAdam AJ. Discrepant analysis: how can we test a test? J Clin Microbiol. 2000 Jun; 38(6):2027-9.
    View in: PubMed
  50. McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH. B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol. 2000 Jan; 74(1):203-8.
    View in: PubMed
  51. Chen AI, McAdam AJ, Buhlmann JE, Scott S, Lupher ML, Greenfield EA, Baum PR, Fanslow WC, Calderhead DM, Freeman GJ, Sharpe AH. Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity. 1999 Dec; 11(6):689-98.
    View in: PubMed
  52. Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol. 1999 Oct 1; 163(7):3753-7.
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  53. Mandelbrot DA, McAdam AJ, Sharpe AH. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J Exp Med. 1999 Jan 18; 189(2):435-40.
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  54. McAdam AJ, Schweitzer AN, Sharpe AH. The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells. Immunol Rev. 1998 Oct; 165:231-47.
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  55. Yeh KY, McAdam AJ, Pulaski BA, Shastri N, Frelinger JG, Lord EM. IL-3 enhances both presentation of exogenous particulate antigen in association with class I major histocompatibility antigen and generation of primary tumor-specific cytolytic T lymphocytes. J Immunol. 1998 Jun 15; 160(12):5773-80.
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  56. Wei C, Storozynsky E, McAdam AJ, Yeh KY, Tilton BR, Willis RA, Barth RK, Looney RJ, Lord EM, Frelinger JG. Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes. Cancer Immunol Immunother. 1996 Jul; 42(6):362-8.
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  57. McAdam AJ, Pulaski BA, Storozynsky E, Yeh KY, Sickel JZ, Frelinger JG, Lord EM. Analysis of the effect of cytokines (interleukins 2, 3, 4, and 6, granulocyte-monocyte colony-stimulating factor, and interferon-gamma) on generation of primary cytotoxic T lymphocytes against a weakly immunogenic tumor. Cell Immunol. 1995 Oct 15; 165(2):183-92.
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  58. Yeh KY, Pulaski BA, Woods ML, McAdam AJ, Gaspari AA, Frelinger JG, Lord EM. B7-1 enhances natural killer cell-mediated cytotoxicity and inhibits tumor growth of a poorly immunogenic murine carcinoma. Cell Immunol. 1995 Oct 15; 165(2):217-24.
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  59. McAdam AJ, Pulaski BA, Harkins SS, Hutter EK, Lord EM, Frelinger JG. Synergistic effects of co-expression of the TH1 cytokines IL-2 and IFN-gamma on generation of murine tumor-reactive cytotoxic cells. Int J Cancer. 1995 May 29; 61(5):628-34.
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  60. McAdam AJ, Felcher A, Woods ML, Pulaski BA, Hutter EK, Frelinger JG, Lord EM. Transfection of transforming growth factor-beta producing tumor EMT6 with interleukin-2 elicits tumor rejection and tumor reactive cytotoxic T-lymphocytes. J Immunother Emphasis Tumor Immunol. 1994 Apr; 15(3):155-64.
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  61. Woods ML, McAdam AJ, Frelinger JG, Lord EM. Isolation and expansion of tumor-infiltrating lymphocytes. Biotechniques. 1993 Dec; 15(6):970-2.
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  62. McAdam AJ, Yeh KY, Pulaski BA, Frelinger JG, Lord EM. Interleukin-3 inhibits the generation of nonspecific killers by interleukin-2. J Immunother Emphasis Tumor Immunol. 1993 Nov; 14(4):293-7.
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  63. McAdam A, Pulaski B, Harkins S, Hutter E, Frelinger J, Lord E. Coexpression of IL-2 and gamma-IFN enhances tumor immunity. Ann N Y Acad Sci. 1993 Aug 12; 690:349-51.
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  64. Pulaski BA, McAdam AJ, Hutter EK, Biggar S, Lord EM, Frelinger JG. Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism. Cancer Res. 1993 May 1; 53(9):2112-7.
    View in: PubMed
  65. McAdam AJ, Blieden TM, Frelinger JG, Lord EM. CD4-class II major histocompatibility complex interaction does not enhance killing by a class I-restricted CD4+CD8+ cytotoxic T cell clone. Eur J Immunol. 1992 Sep; 22(9):2461-4.
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  66. Blieden TM, McAdam AJ, Frelinger JG, Lord EM. Mechanism of cytolytic T lymphocyte killing of a low class I-expressing tumor. J Immunol. 1991 Aug 15; 147(4):1433-8.
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  67. Blieden TM, McAdam AJ, Foresman MD, Cerosaletti KM, Frelinger JG, Lord EM. Class-I MHC expression in the mouse lung carcinoma, line 1: a model for class-I inducible tumors. Int J Cancer Suppl. 1991; 6:82-9.
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  68. Jonassen JA, Mullikin-Kilpatrick D, McAdam A, Leeman SE. Thyroid hormone status regulates preprotachykinin-A gene expression in male rat anterior pituitary. Endocrinology. 1987 Oct; 121(4):1555-61.
    View in: PubMed
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