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Last Name
Institution

Caroline Elizabeth Shamu, Ph.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressHarvard Medical School
Seeley Mudd Bldg-ICCB Screening Facility
250 Longwood Ave
Boston MA 02115
Phone617/432-3127
Fax617/432-6424
Other Positions
TitleDirector of ICCB Longwood Facility
InstitutionHarvard Medical School
DepartmentICCB

TitleLecturer on Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology


 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
ICCB-Longwood Screening Facility (HMS) - Core services (5), Gene knockdown screening libraries (22), Instruments (38), Small molecule Screening libraries (62) and Software (3)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Tang Y, Xie T, Florian S, Moerke N, Shamu C, Benes C, Mitchison TJ. Differential determinants of cancer cell insensitivity to antimitotic drugs discriminated by a one-step cell imaging assay. J Biomol Screen. 2013 Oct; 18(9):1062-71.
    View in: PubMed
  2. Shamu CE, Wiemann S, Boutros M. On target: a public repository for large-scale RNAi experiments. Nat Cell Biol. 2012 Feb; 14(2):115.
    View in: PubMed
  3. Sansone SA, Rocca-Serra P, Field D, Maguire E, Taylor C, Hofmann O, Fang H, Neumann S, Tong W, Amaral-Zettler L, Begley K, Booth T, Bougueleret L, Burns G, Chapman B, Clark T, Coleman LA, Copeland J, Das S, de Daruvar A, de Matos P, Dix I, Edmunds S, Evelo CT, Forster MJ, Gaudet P, Gilbert J, Goble C, Griffin JL, Jacob D, Kleinjans J, Harland L, Haug K, Hermjakob H, Ho Sui SJ, Laederach A, Liang S, Marshall S, McGrath A, Merrill E, Reilly D, Roux M, Shamu CE, Shang CA, Steinbeck C, Trefethen A, Williams-Jones B, Wolstencroft K, Xenarios I, Hide W. Toward interoperable bioscience data. Nat Genet. 2012 Feb; 44(2):121-6.
    View in: PubMed
  4. Harris ES, Erickson SD, Tolopko AN, Cao S, Craycroft JA, Scholten R, Fu Y, Wang W, Liu Y, Zhao Z, Clardy J, Shamu CE, Eisenberg DM. Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs. J Ethnopharmacol. 2011 May 17; 135(2):590-3.
    View in: PubMed
  5. Eisenberg DM, Harris ES, Littlefield BA, Cao S, Craycroft JA, Scholten R, Bayliss P, Fu Y, Wang W, Qiao Y, Zhao Z, Chen H, Liu Y, Kaptchuk T, Hahn WC, Wang X, Roberts T, Shamu CE, Clardy J. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. Fitoterapia. 2011 Jan; 82(1):17-33.
    View in: PubMed
  6. Tolopko AN, Sullivan JP, Erickson SD, Wrobel D, Chiang SL, Rudnicki K, Rudnicki S, Nale J, Selfors LM, Greenhouse D, Muhlich JL, Shamu CE. Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities. BMC Bioinformatics. 2010; 11:260.
    View in: PubMed
  7. Hoffman GR, Moerke NJ, Hsia M, Shamu CE, Blenis J. A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay Drug Dev Technol. 2010 Apr; 8(2):186-99.
    View in: PubMed
  8. Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS One. 2009; 4(10):e7339.
    View in: PubMed
  9. Birmingham A, Selfors LM, Forster T, Wrobel D, Kennedy CJ, Shanks E, Santoyo-Lopez J, Dunican DJ, Long A, Kelleher D, Smith Q, Beijersbergen RL, Ghazal P, Shamu CE. Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods. 2009 Aug; 6(8):569-75.
    View in: PubMed
  10. Inglese J, Shamu CE, Guy RK. Reporting data from high-throughput screening of small-molecule libraries. Nat Chem Biol. 2007 Aug; 3(8):438-41.
    View in: PubMed
  11. Parker CN, Shamu CE, Kraybill B, Austin CP, Bajorath J. Measure, mine, model, and manipulate: the future for HTS and chemoinformatics? Drug Discov Today. 2006 Oct; 11(19-20):863-5.
    View in: PubMed
  12. Shamu CE, Flierman D, Ploegh HL, Rapoport TA, Chau V. Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Mol Biol Cell. 2001 Aug; 12(8):2546-55.
    View in: PubMed
  13. Casagrande R, Stern P, Diehn M, Shamu C, Osario M, Zúñiga M, Brown PO, Ploegh H. Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway. Mol Cell. 2000 Apr; 5(4):729-35.
    View in: PubMed
  14. Shamu CE, Story CM, Rapoport TA, Ploegh HL. The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol. 1999 Oct 4; 147(1):45-58.
    View in: PubMed
  15. Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D. Evidence for evolutionary conservation of sex-determining genes. Nature. 1998 Feb 12; 391(6668):691-5.
    View in: PubMed
  16. Shamu CE. Splicing: HACking into the unfolded-protein response. Curr Biol. 1998 Feb 12; 8(4):R121-3.
    View in: PubMed
  17. Shamu CE. Splicing together the unfolded-protein response. Curr Biol. 1997 Feb 1; 7(2):R67-70.
    View in: PubMed
  18. Shamu CE, Walter P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 1996 Jun 17; 15(12):3028-39.
    View in: PubMed
  19. Shamu CE, Cox JS, Walter P. The unfolded-protein-response pathway in yeast. Trends Cell Biol. 1994 Feb; 4(2):56-60.
    View in: PubMed
  20. Cox JS, Shamu CE, Walter P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell. 1993 Jun 18; 73(6):1197-206.
    View in: PubMed
  21. Shamu CE, Murray AW. Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase. J Cell Biol. 1992 Jun; 117(5):921-34.
    View in: PubMed
  22. Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L. C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature. 1992 Feb 27; 355(6363):841-5.
    View in: PubMed
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