Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Boris E. Shmukler, PH.D.

TitleInstructor in Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Molecular Medicine, RW-763
330 Brookline Ave
Boston MA 02215
Phone617/667-2922
Fax617/667-8040

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Chattaraj P, Reimold FR, Muskett JA, Shmukler BE, Chien WW, Madeo AC, Pryor SP, Zalewski CK, Butman JA, Brewer CC, Kenna MA, Alper SL, Griffith AJ. Use of SLC26A4 Mutation Testing for Unilateral Enlargement of the Vestibular Aqueduct. JAMA Otolaryngol Head Neck Surg. 2013 Sep 1; 139(9):907-13.
    View in: PubMed
  2. Shmukler BE, Vandorpe DH, Rivera A, Auerbach M, Brugnara C, Alper SL. Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report. Blood Cells Mol Dis. 2014 Jan; 52(1):53-4.
    View in: PubMed
  3. Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A. Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 9; 121(19):3925-35.
    View in: PubMed
  4. Shmukler BE, Hsu A, Alves J, Trudel M, Rust MB, Hubner CA, Rivera A, Alper SL. N-ethylmaleimide activates a Cl(-)-independent component of K(+) flux in mouse erythrocytes. Blood Cells Mol Dis. 2013 Jun; 51(1):9-16.
    View in: PubMed
  5. Shmukler BE, Mukodzi S, Andres O, Eber S, Alper SL. Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout. Br J Haematol. 2013 May; 161(4):602-4.
    View in: PubMed
  6. Reimold FR, Stewart AK, Stolpe K, Heneghan JF, Shmukler BE, Alper SL. Substitution of transmembrane domain Cys residues alters pHo-sensitive anion transport by AE2/SLC4A2 anion exchanger. Pflugers Arch. 2013 Jun; 465(6):839-51.
    View in: PubMed
  7. Andolfo I, Alper SL, Delaunay J, Auriemma C, Russo R, Asci R, Esposito MR, Sharma AK, Shmukler BE, Brugnara C, De Franceschi L, Iolascon A. Missense mutations in the ABCB6 transporter cause dominant familialpseudohyperkalemia. Am J Hematol. 2013 Jan; 88(1):66-72.
    View in: PubMed
  8. Shmukler BE, Rivera A, Vandorpe DH, Alves J, Bonfanti U, Paltrinieri S, Alper SL. Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease. Blood Cells Mol Dis. 2012 Apr 15; 48(4):219-25.
    View in: PubMed
  9. Reimold FR, Heneghan JF, Stewart AK, Zelikovic I, Vandorpe DH, Shmukler BE, Alper SL. Pendrin function and regulation in Xenopus oocytes. Cell Physiol Biochem. 2011; 28(3):435-50.
    View in: PubMed
  10. Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43.
    View in: PubMed
  11. Stewart AK, Shmukler BE, Vandorpe DH, Reimold F, Heneghan JF, Nakakuki M, Akhavein A, Ko S, Ishiguro H, Alper SL. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C289-303.
    View in: PubMed
  12. Stewart AK, Chebib FT, Akbar SW, Salas MJ, Sonik RA, Shmukler BE, Alper SL. Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1. Biochem Cell Biol. 2011 Apr; 89(2):224-35.
    View in: PubMed
  13. Stewart AK, Kedar PS, Shmukler BE, Vandorpe DH, Hsu A, Glader B, Rivera A, Brugnara C, Alper SL. Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis. Am J Physiol Cell Physiol. 2011 May; 300(5):C1034-46.
    View in: PubMed
  14. Shmukler BE, Kedar PS, Warang P, Desai M, Madkaikar M, Ghosh K, Colah RB, Alper SL. Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D. Am J Hematol. 2010 Oct; 85(10):824-8.
    View in: PubMed
  15. Heneghan JF, Akhavein A, Salas MJ, Shmukler BE, Karniski LP, Vandorpe DH, Alper SL. Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1363-75.
    View in: PubMed
  16. Vandorpe DH, Xu C, Shmukler BE, Otterbein LE, Trudel M, Sachs F, Gottlieb PA, Brugnara C, Alper SL. Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010; 5(1):e8732.
    View in: PubMed
  17. Casula S, Zolotarev AS, Stuart-Tilley AK, Wilhelm S, Shmukler BE, Brugnara C, Alper SL. Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter. Blood Cells Mol Dis. 2009 May-Jun; 42(3):233-40.
    View in: PubMed
  18. Xu C, Shmukler BE, Nishimura K, Kaczmarek E, Rossetti S, Harris PC, Wandinger-Ness A, Bacallao RL, Alper SL. Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol. 2009 Jun; 296(6):F1464-76.
    View in: PubMed
  19. Stewart AK, Shmukler BE, Vandorpe DH, Alper SL. Molecular characterization of Slc26a3 and Slc26a6 anion transporters in guinea pig pancreatic duct. J Med Invest. 2009; 56 Suppl:329-31.
    View in: PubMed
  20. Kurschat CE, Shmukler BE, Jiang L, Hevi S, Kim EH, Stewart AK, Alper SL. Mouse strain-specific coding polymorphism in the Slc4a2/Ae2 gene encodes Ae2c2 variants differing in isoform-specific dominant negative activity. Exp Physiol. 2008 Apr; 93(4):458-67.
    View in: PubMed
  21. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66.
    View in: PubMed
  22. Shmukler BE, Clark JS, Hsu A, Vandorpe DH, Stewart AK, Kurschat CE, Choe SK, Zhou Y, Amigo J, Paw BH, Alper SL. Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Am J Physiol Regul Integr Comp Physiol. 2008 Mar; 294(3):R1081-91.
    View in: PubMed
  23. Stewart AK, Kurschat CE, Vaughan-Jones RD, Shmukler BE, Alper SL. Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain. J Physiol. 2007 Oct 1; 584(Pt 1):59-73.
    View in: PubMed
  24. Rust MB, Alper SL, Rudhard Y, Shmukler BE, Vicente R, Brugnara C, Trudel M, Jentsch TJ, Hübner CA. Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. J Clin Invest. 2007 Jun; 117(6):1708-17.
    View in: PubMed
  25. Stehberger PA, Shmukler BE, Stuart-Tilley AK, Peters LL, Alper SL, Wagner CA. Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). J Am Soc Nephrol. 2007 May; 18(5):1408-18.
    View in: PubMed
  26. Kurschat CE, Shmukler BE, Jiang L, Wilhelm S, Kim EH, Chernova MN, Kinne RK, Stewart AK, Alper SL. Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange reveals novel regulatory determinants in the AE2 N-terminal cytoplasmic domain. J Biol Chem. 2006 Jan 27; 281(4):1885-96.
    View in: PubMed
  27. Shmukler BE, Kurschat CE, Ackermann GE, Jiang L, Zhou Y, Barut B, Stuart-Tilley AK, Zhao J, Zon LI, Drummond IA, Vandorpe DH, Paw BH, Alper SL. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F835-49.
    View in: PubMed
  28. Dahl NK, Jiang L, Chernova MN, Stuart-Tilley AK, Shmukler BE, Alper SL. Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer. J Biol Chem. 2003 Nov 7; 278(45):44949-58.
    View in: PubMed
  29. Chernova MN, Jiang L, Shmukler BE, Schweinfest CW, Blanco P, Freedman SD, Stewart AK, Alper SL. Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol. 2003 May 15; 549(Pt 1):3-19.
    View in: PubMed
  30. Stewart AK, Chernova MN, Shmukler BE, Wilhelm S, Alper SL. Regulation of AE2-mediated Cl- transport by intracellular or by extracellular pH requires highly conserved amino acid residues of the AE2 NH2-terminal cytoplasmic domain. J Gen Physiol. 2002 Nov; 120(5):707-22.
    View in: PubMed
  31. Roussa E, Shmukler BE, Wilhelm S, Casula S, Stuart-Tilley AK, Thévenod F, Alper SL. Immunolocalization of potassium-chloride cotransporter polypeptides in rat exocrine glands. Histochem Cell Biol. 2002 Apr; 117(4):335-44.
    View in: PubMed
  32. Casula S, Shmukler BE, Wilhelm S, Stuart-Tilley AK, Su W, Chernova MN, Brugnara C, Alper SL. A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J Biol Chem. 2001 Nov 9; 276(45):41870-8.
    View in: PubMed
  33. Shmukler BE, Bond CT, Wilhelm S, Bruening-Wright A, Maylie J, Adelman JP, Alper SL. Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Biochim Biophys Acta. 2001 Mar 19; 1518(1-2):36-46.
    View in: PubMed
  34. Papageorgiou P, Shmukler BE, Stuart-Tilley AK, Jiang L, Alper SL. AE anion exchangers in atrial tumor cells. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H937-45.
    View in: PubMed
  35. Loffing J, Moyer BD, Reynolds D, Shmukler BE, Alper SL, Stanton BA. Functional and molecular characterization of an anion exchanger in airway serous epithelial cells. Am J Physiol Cell Physiol. 2000 Oct; 279(4):C1016-23.
    View in: PubMed
  36. Shmukler BE, Brugnara C, Alper SL. Structure and genetic polymorphism of the mouse KCC1 gene. Biochim Biophys Acta. 2000 Jul 24; 1492(2-3):353-61.
    View in: PubMed
  37. Shmukler BE, Wilhelm S, Alper SL. Short sequence repeat polymorphism in the mouse slc4al gene encoding the AE1 Cl-/HCO3-exchanger. DNA Seq. 2000; 11(5):447-50.
    View in: PubMed
  38. Su W, Shmukler BE, Chernova MN, Stuart-Tilley AK, de Franceschi L, Brugnara C, Alper SL. Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. Am J Physiol. 1999 Nov; 277(5 Pt 1):C899-912.
    View in: PubMed
  39. Alper SL, Rossmann H, Wilhelm S, Stuart-Tilley AK, Shmukler BE, Seidler U. Expression of AE2 anion exchanger in mouse intestine. Am J Physiol. 1999 Aug; 277(2 Pt 1):G321-32.
    View in: PubMed
  40. Zolotarev AS, Shmukler BE, Alper SL. AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study. Biochemistry. 1999 Jun 29; 38(26):8521-31.
    View in: PubMed
  41. Vandorpe DH, Shmukler BE, Jiang L, Lim B, Maylie J, Adelman JP, de Franceschi L, Cappellini MD, Brugnara C, Alper SL. cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21; 273(34):21542-53.
    View in: PubMed
  42. Stuart-Tilley AK, Shmukler BE, Brown D, Alper SL. Immunolocalization and tissue-specific splicing of AE2 anion exchanger in mouse kidney. J Am Soc Nephrol. 1998 Jun; 9(6):946-59.
    View in: PubMed
  43. Alper SL, Stuart-Tilley AK, Biemesderfer D, Shmukler BE, Brown D. Immunolocalization of AE2 anion exchanger in rat kidney. Am J Physiol. 1997 Oct; 273(4 Pt 2):F601-14.
    View in: PubMed
  44. Shmukler B, Sun T, Brugnara C, Alper SL. Reinterpretation of the RACTK1 K+ channel. Am J Physiol. 1997 Jan; 272(1 Pt 1):C350-4.
    View in: PubMed
  45. Khramtsov NV, Feshchenko EA, Suslova VA, Shmukler BE, Terpugov BE, Rakitina TV, Atabekova NV, Lipkin VM. The human rod photoreceptor cGMP phosphodiesterase beta-subunit. Structural studies of its cDNA and gene. FEBS Lett. 1993 Aug 2; 327(3):275-8.
    View in: PubMed
  46. Shmukler BE, Zubov DV, Abdulaev NG. [Detection of expression of a membrane form of the guanylate cyclase type of GC-B in cattle retina]. Bioorg Khim. 1993 Jun; 19(6):682-5.
    View in: PubMed
  47. Khramtsov NV, Feshchenko EA, Suslova VA, Terpugov BE, Rakitina TV, Atabekova NV, Shmukler BE, Lipkin VM. [Structural studies of cDNA and the gene for the beta-subunit of cGMP phosphodiesterase from human retina]. Bioorg Khim. 1992 Dec; 18(12):1551-4.
    View in: PubMed
  48. Kutuzov MA, Shmukler BE, Suslov ON, Zargarov AA, Abdulaev NG. [p26--a calcium binding protein from photoreceptor cells in the bovine retina: primary structure and expression in E. coli]. Bioorg Khim. 1992 May; 18(5):623-34.
    View in: PubMed
  49. Kutuzov MA, Shmukler BE, Suslov ON, Dergachev AE, Zargarov AA, Abdulaev NG. P26-calcium binding protein from bovine retinal photoreceptor cells. FEBS Lett. 1991 Nov 18; 293(1-2):21-4.
    View in: PubMed
  50. Kutuzov MA, Shmukler BE, Zargarov AA, Telezhinskaia IN, Levina NB, Zolotarev AS, Abdulaev NG. [Study of the structure of the photosynthetic reaction center of the green thermophilic bacteria Chloroflexus aurantiacus]. Bioorg Khim. 1990 Sep; 16(9):1218-35.
    View in: PubMed
  51. Zozulya SA, Gurevich VV, Zvyaga TA, Shirokova EP, Dumler IL, Garnovskaya MN. Functional expression in vitro of bovine visual rhodopsin. Protein Eng. 1990 Apr; 3(5):453-8.
    View in: PubMed
  52. Gurevich VV, Zozulia SA, Shirokova EP, Zviaga TA, Garnovskaia MN, Dumler IL, Badalov PR, Natochin MIu, Pokrovskaia ID, Shmukler BE. [Synthesis of visual rhodopsin in a cell-free translation system. II. Functional properties of recombinant rhodopsin and its mutant forms]. Bioorg Khim. 1990 Mar; 16(3):303-8.
    View in: PubMed
  53. Zozulya SA, Gurevich VV, Zvyaga TA, Dumler IL, Garnovskaya MN, Shmukler BE. In vitro synthesis of visual rhodopsin for a protein engineering study. J Protein Chem. 1989 Jun; 8(3):380-2.
    View in: PubMed
  54. Zozulia SA, Gurevich VV, Shmukler BE, Namochin MIu, Zviaga TA. [Synthesis of visual rhodopsin in a cell-free translation system. I. Influence of the structure of the synthetic bovine visual opsin mRNA on its translational efficiency]. Bioorg Khim. 1988 Dec; 14(12):1663-70.
    View in: PubMed
  55. Photosynthetic reaction centre of Chloroflexus aurantiacus. I. Primary structure of L-subunit. FEBS Lett. 1988 Apr 11; 231(1):237-42.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Shmukler's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_