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Carlos F. Fernandez-Del Castillo, M.D.

TitleProfessor of Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
Wacc 460
55 Fruit St
Boston MA 02114
Phone617/726-5644

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Perez-Johnston R, Narin O, Mino-Kenudson M, Ingkakul T, Warshaw AL, Fernandez-Del Castillo C, Sahani VD. Frequency and significance of calcification in IPMN. Pancreatology. 2013 Jan; 13(1):43-7.
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  2. Warshaw AL, Lillemoe KD, Fernandez-del Castillo C. Pancreatic surgery for adenocarcinoma. Curr Opin Gastroenterol. 2012 Sep; 28(5):488-93.
    View in: PubMed
  3. Wang H, Chen Y, Fernandez-Del Castillo C, Yilmaz O, Deshpande V. Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. Mod Pathol. 2013 Jan; 26(1):139-47.
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  4. Albutt K, Bailen L, Fernandez-Del Castillo C. A patient with recurrent pancreatitis. Gastroenterology. 2012 Oct; 143(4):896, 1121-2.
    View in: PubMed
  5. Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012 Sep; 25(9):1181-92.
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  6. Arvold ND, Willett CG, Fernandez-del Castillo C, Ryan DP, Ferrone CR, Clark JW, Blaszkowsky LS, Deshpande V, Niemierko A, Allen JN, Kwak EL, Wadlow RC, Zhu AX, Warshaw AL, Hong TS. Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy. Int J Radiat Oncol Biol Phys. 2012 Jul 1; 83(3):e337-43.
    View in: PubMed
  7. Konstantinidis IT, Bajpai S, Kambadakone AR, Tanabe KK, Berger DL, Zheng H, Sahani DV, Lauwers GY, Fernandez-del Castillo C, Warshaw AL, Ferrone CR. Gallbladder lesions identified on ultrasound. Lessons from the last 10 years. J Gastrointest Surg. 2012 Mar; 16(3):549-53.
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  8. Arvold ND, Ryan DP, Niemierko A, Blaszkowsky LS, Kwak EL, Wo JY, Allen JN, Clark JW, Wadlow RC, Zhu AX, Fernandez-Del Castillo C, Hong TS. Long-term outcomes of neoadjuvant chemotherapy before chemoradiation for locally advanced pancreatic cancer. Cancer. 2012 Jun 15; 118(12):3026-35.
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  9. Alexander BM, Fernandez-Del Castillo C, Ryan DP, Kachnic LA, Hezel AF, Niemierko A, Willett CG, Kozak KR, Blaszkowsky LS, Clark JW, Warshaw AL, Hong TS. Intraductal papillary mucinous adenocarcinoma of the pancreas: clinical outcomes, prognostic factors, and the role of adjuvant therapy. Gastrointest Cancer Res. 2011 Jul; 4(4):116-21.
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  10. Ferrone CR, Konstantinidis IT, Sahani DV, Wargo JA, Fernandez-del Castillo C, Warshaw AL. Twenty-three years of the Warshaw operation for distal pancreatectomy with preservation of the spleen. Ann Surg. 2011 Jun; 253(6):1136-9.
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  11. Xiao HD, Yamaguchi H, Dias-Santagata D, Kuboki Y, Akhavanfard S, Hatori T, Yamamoto M, Shiratori K, Kobayashi M, Shimizu M, Fernandez-Del Castillo C, Mino-Kenudson M, Furukawa T. Molecular characteristics and biological behaviours of the oncocytic and pancreatobiliary subtypes of intraductal papillary mucinous neoplasms. J Pathol. 2011 Aug; 224(4):508-16.
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  12. Lennerz JK, Fernandez-Del Castillo C, Pitman MB. Mixed ductal-endocrine carcinoma of the pancreas metastatic to the liver. Pancreas. 2011 Mar; 40(2):319-21.
    View in: PubMed
  13. Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernandez-del Castillo C, Warshaw AL, Ferrone CR. Metastatic tumors in the pancreas in the modern era. J Am Coll Surg. 2010 Dec; 211(6):749-53.
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  14. Konstantinidis IT, Warshaw AL, Deshpande V, Sahani D, Berger D, Fernandez-del Castillo C, Ferrone CR. Cholesterol crystal embolization presenting as either solid or cystic pancreatic lesion. J Surg Oncol. 2010 Nov 1; 102(6):706-8.
    View in: PubMed
  15. Arvold ND, Niemierko A, Mamon HJ, Fernandez-del Castillo C, Hong TS. Pancreatic cancer tumor size on CT scan versus pathologic specimen: implications for radiation treatment planning. Int J Radiat Oncol Biol Phys. 2011 Aug 1; 80(5):1383-90.
    View in: PubMed
  16. Hong TS, Ryan DP, Blaszkowsky LS, Mamon HJ, Kwak EL, Mino-Kenudson M, Adams J, Yeap B, Winrich B, DeLaney TF, Fernandez-Del Castillo C. Phase I study of preoperative short-course chemoradiation with proton beam therapy and capecitabine for resectable pancreatic ductal adenocarcinoma of the head. Int J Radiat Oncol Biol Phys. 2011 Jan 1; 79(1):151-7.
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  17. Partelli S, Fernandez-Del Castillo C, Bassi C, Mantovani W, Thayer SP, Crippa S, Ferrone CR, Falconi M, Pederzoli P, Warshaw AL, Salvia R. Invasive intraductal papillary mucinous carcinomas of the pancreas: predictors of survival and the role of lymph node ratio. Ann Surg. 2010 Mar; 251(3):477-82.
    View in: PubMed
  18. Pitman MB, Lewandrowski K, Shen J, Sahani D, Brugge W, Fernandez-del Castillo C. Pancreatic cysts: preoperative diagnosis and clinical management. Cancer Cytopathol. 2010 Feb 25; 118(1):1-13.
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  19. Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernandez-del Castillo C, Thayer SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR. Does the mechanism of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma? J Gastrointest Surg. 2010 Feb; 14(2):261-7.
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  20. Miyamoto DT, Mamon HJ, Ryan DP, Willett CG, Ancukiewicz M, Kobayashi WK, Blaszkowsky L, Fernandez-del Castillo C, Hong TS. Outcomes and tolerability of chemoradiation therapy for pancreatic cancer patients aged 75 years or older. Int J Radiat Oncol Biol Phys. 2010 Jul 15; 77(4):1171-7.
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  21. Konstantinidis IT, Deshpande V, Genevay M, Berger D, Fernandez-del Castillo C, Tanabe KK, Zheng H, Lauwers GY, Ferrone CR. Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg. 2009 May; 144(5):441-7; discussion 447.
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  22. Fritz S, Fernandez-del Castillo C, Mino-Kenudson M, Crippa S, Deshpande V, Lauwers GY, Warshaw AL, Thayer SP, Iafrate AJ. Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma. Ann Surg. 2009 Mar; 249(3):440-7.
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  23. Correa-Gallego C, Warshaw AL, Fernandez-del Castillo C. Fluid CEA in IPMNs: A useful test or the flip of a coin? Am J Gastroenterol. 2009 Mar; 104(3):796-7.
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  24. Keck T, Marjanovic G, Fernandez-del Castillo C, Makowiec F, Schäfer AO, Rodriguez JR, Razo O, Hopt UT, Warshaw AL. The inflammatory pancreatic head mass: significant differences in the anatomic pathology of German and American patients with chronic pancreatitis determine very different surgical strategies. Ann Surg. 2009 Jan; 249(1):105-10.
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  25. Sahani DV, Sainani NI, Deshpande V, Shaikh MS, Frinkelberg DL, Fernandez-del Castillo C. Autoimmune pancreatitis: disease evolution, staging, response assessment, and CT features that predict response to corticosteroid therapy. Radiology. 2009 Jan; 250(1):118-29.
    View in: PubMed
  26. Cevasco M, Rodriguez JR, Fernandez-del Castillo C. Clinical challenges and images in GI: image 3. Pancreatic acinar cell carcinoma with subcutaneous fat necrosis. Gastroenterology. 2008 Oct; 135(4):1054, 1433.
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  27. Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, Rodriguez R, Thayer SP, Fernandez-del Castillo C. Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg. 2008 Oct; 12(10):1691-7; discussion 1697-8.
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  28. Singh AK, Sahani DV, Blake MA, Joshi MC, Wargo JA, Fernandez-del Castillo C. Assessment of pancreatic tumor resectability with multidetector computed tomography: semiautomated console-generated images versus dedicated workstation-generated images. Acad Radiol. 2008 Aug; 15(8):1058-68.
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  29. Kozak KR, Kachnic LA, Adams J, Crowley EM, Alexander BM, Mamon HJ, Fernandez-Del Castillo C, Ryan DP, DeLaney TF, Hong TS. Dosimetric feasibility of hypofractionated proton radiotherapy for neoadjuvant pancreatic cancer treatment. Int J Radiat Oncol Biol Phys. 2007 Aug 1; 68(5):1557-66.
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  30. Sahani DV, Kadavigere R, Blake M, Fernandez-Del Castillo C, Lauwers GY, Hahn PF. Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations--correlation with MRCP. Radiology. 2006 Feb; 238(2):560-9.
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  31. Sahani DV, Saokar A, Hahn PF, Brugge WR, Fernandez-Del Castillo C. Pancreatic cysts 3 cm or smaller: how aggressive should treatment be? Radiology. 2006 Mar; 238(3):912-9.
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  32. Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology. 2006; 6(1-2):17-32.
    View in: PubMed
  33. Sahani DV, Kadavigere R, Saokar A, Fernandez-del Castillo C, Brugge WR, Hahn PF. Cystic pancreatic lesions: a simple imaging-based classification system for guiding management. Radiographics. 2005 Nov-Dec; 25(6):1471-84.
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  34. Deshpande V, Mino-Kenudson M, Brugge WR, Pitman MB, Fernandez-del Castillo C, Warshaw AL, Lauwers GY. Endoscopic ultrasound guided fine needle aspiration biopsy of autoimmune pancreatitis: diagnostic criteria and pitfalls. Am J Surg Pathol. 2005 Nov; 29(11):1464-71.
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  35. Longnecker DS, Adsay NV, Fernandez-del Castillo C, Hruban RH, Kasugai T, Klimstra DS, Klöppel G, Lüttges J, Memoli VA, Tosteson TD, Yanagisawa A, Wilentz R, Zamboni G. Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms: interobserver agreement. Pancreas. 2005 Nov; 31(4):344-9.
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  36. Tseng JF, Warshaw AL, Sahani DV, Lauwers GY, Rattner DW, Fernandez-del Castillo C. Serous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment. Ann Surg. 2005 Sep; 242(3):413-9; discussion 419-21.
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  37. Ryan DP, Fernandez-del Castillo C, Willett CG, Brugge WR, Sahani D, Brachtel EF. Case records of the Massachusetts General Hospital. Case 20-2005. A 58-year-old man with locally advanced pancreatic cancer. N Engl J Med. 2005 Jun 30; 352(26):2734-41.
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  38. Tseng JF, Willett CG, Fernandez-del Castillo C, Ryan DP, Clark JW, Zhu AX, Rattner DW, Winkelmann JL, Warshaw AL. Patients undergoing treatment for pancreatic adenocarcinoma can mount an effective immune response to vaccinations. Pancreatology. 2005; 5(1):67-74.
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  39. Brugge WR, Lauwers GY, Sahani D, Fernandez-del Castillo C, Warshaw AL. Cystic neoplasms of the pancreas. N Engl J Med. 2004 Sep 16; 351(12):1218-26.
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  40. Deshpande V, Fernandez-del Castillo C, Muzikansky A, Deshpande A, Zukerberg L, Warshaw AL, Lauwers GY. Cytokeratin 19 is a powerful predictor of survival in pancreatic endocrine tumors. Am J Surg Pathol. 2004 Sep; 28(9):1145-53.
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  41. Jimenez RE, Fernandez-Del Castillo C, Rattner DW, Warshaw AL. Pylorus-preserving pancreaticoduodenectomy in the treatment of chronic pancreatitis. World J Surg. 2003 Nov; 27(11):1211-6.
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  42. Prasad SR, Sahani D, Nasser S, Farrell J, Fernandez-Del Castillo C, Hahn PF, Mueller PR, Saini S. Intraductal papillary mucinous tumors of the pancreas. Abdom Imaging. 2003 May-Jun; 28(3):357-65.
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  43. Deshpande V, Selig MK, Nielsen GP, Fernandez-del Castillo C, Lauwers GY. Ductulo-insular pancreatic endocrine neoplasms: clinicopathologic analysis of a unique subtype of pancreatic endocrine neoplasms. Am J Surg Pathol. 2003 Apr; 27(4):461-8.
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  44. Raut CP, Fernandez-del Castillo C. Giant lipoma of the pancreas: case report and review of lipomatous lesions of the pancreas. Pancreas. 2003 Jan; 26(1):97-9.
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  45. Hartwig W, Carter EA, Jimenez RE, Jones R, Fischman AJ, Fernandez-Del Castillo C, Warshaw AL. Neutrophil metabolic activity but not neutrophil sequestration reflects the development of pancreatitis-associated lung injury. Crit Care Med. 2002 Sep; 30(9):2075-82.
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  46. Fernandez-del Castillo C. Surgical treatment of intraductal papillary mucinous neoplasms of the pancreas: the conservative approach. J Gastrointest Surg. 2002 Sep-Oct; 6(5):660-1.
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  47. McMahon PM, Halpern EF, Fernandez-del Castillo C, Clark JW, Gazelle GS. Pancreatic cancer: cost-effectiveness of imaging technologies for assessing resectability. Radiology. 2001 Oct; 221(1):93-106.
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  48. Werner J, Saghir M, Fernandez-del Castillo C, Warshaw AL, Laposata M. Linkage of oxidative and nonoxidative ethanol metabolism in the pancreas and toxicity of nonoxidative ethanol metabolites for pancreatic acinar cells. Surgery. 2001 Jun; 129(6):736-44.
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  49. Z'graggen K, Centeno BA, Fernandez-del Castillo C, Jimenez RE, Werner J, Warshaw AL. Biological implications of tumor cells in blood and bone marrow of pancreatic cancer patients. Surgery. 2001 May; 129(5):537-46.
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  50. Gervais DA, Fernandez-del Castillo C, O'Neill MJ, Hahn PF, Mueller PR. Complications after pancreatoduodenectomy: imaging and imaging-guided interventional procedures. Radiographics. 2001 May-Jun; 21(3):673-90.
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  51. Balcom JH, Rattner DW, Warshaw AL, Chang Y, Fernandez-del Castillo C. Ten-year experience with 733 pancreatic resections: changing indications, older patients, and decreasing length of hospitalization. Arch Surg. 2001 Apr; 136(4):391-8.
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  52. Hartwig W, Jimenez RE, Fernandez-del Castillo C, Kelliher A, Jones R, Warshaw AL. Expression of the adhesion molecules Mac-1 and L-selectin on neutrophils in acute pancreatitis is protease- and complement-dependent. Ann Surg. 2001 Mar; 233(3):371-8.
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  53. Jimenez RE, Warshaw AL, Rattner DW, Willett CG, McGrath D, Fernandez-del Castillo C. Impact of laparoscopic staging in the treatment of pancreatic cancer. Arch Surg. 2000 Apr; 135(4):409-14; discussion 414-5.
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  54. Balcom IV JH, Fernandez-Del Castillo C, Warshaw AL. Cystic lesions in the pancreas: when to watch, when to resect. Curr Gastroenterol Rep. 2000 Apr; 2(2):152-8.
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  55. Jimenez RE, Fernandez-del Castillo C, Rattner DW, Chang Y, Warshaw AL. Outcome of pancreaticoduodenectomy with pylorus preservation or with antrectomy in the treatment of chronic pancreatitis. Ann Surg. 2000 Mar; 231(3):293-300.
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  56. Fernandez-del Castillo C, Warshaw AL. [Parenchymal necrosis: infection and other indications for debridement and drainage]. Chirurg. 2000 Mar; 71(3):269-73.
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  57. Jimenez RE, Warshaw AL, Fernandez-Del Castillo C. Laparoscopy and peritoneal cytology in the staging of pancreatic cancer. J Hepatobiliary Pancreat Surg. 2000; 7(1):15-20.
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  58. O'Malley ME, Boland GW, Wood BJ, Fernandez-del Castillo C, Warshaw AL, Mueller PR. Adenocarcinoma of the head of the pancreas: determination of surgical unresectability with thin-section pancreatic-phase helical CT. AJR Am J Roentgenol. 1999 Dec; 173(6):1513-8.
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  59. Hartwig W, Carter EA, Jimenez RE, Werner J, Fischman AJ, Fernandez-Del Castillo C, Warshaw AL. Chemotactic peptide uptake in acute pancreatitis: correlation with tissue accumulation of leukocytes. J Appl Physiol. 1999 Aug; 87(2):743-9.
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  60. Jimenez RE, Z'graggen K, Hartwig W, Graeme-Cook F, Warshaw AL, Fernandez-del Castillo C. Immunohistochemical characterization of pancreatic tumors induced by dimethylbenzanthracene in rats. Am J Pathol. 1999 Apr; 154(4):1223-9.
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  61. Rattner DW, Fernandez-del Castillo C, Warshaw AL. Cystic pancreatic neoplasms. Ann Oncol. 1999; 10 Suppl 4:104-6.
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  62. Werner J, Dragotakes SC, Fernandez-del Castillo C, Rivera JA, Ou J, Rattner DW, Fischman AJ, Warshaw AL. Technetium-99m-labeled white blood cells: a new method to define the local and systemic role of leukocytes in acute experimental pancreatitis. Ann Surg. 1998 Jan; 227(1):86-94.
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  63. Quirk DM, Rattner DW, Fernandez-del Castillo C, Warshaw AL, Brugge WR. The use of endoscopic ultrasonography to reduce the cost of treating ampullary tumors. Gastrointest Endosc. 1997 Oct; 46(4):334-7.
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  64. Tenner S, Fernandez-del Castillo C, Warshaw A, Steinberg W, Hermon-Taylor J, Valenzuela JE, Hariri M, Hughes M, Banks PA. Urinary trypsinogen activation peptide (TAP) predicts severity in patients with acute pancreatitis. Int J Pancreatol. 1997 Apr; 21(2):105-10.
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  65. Werner J, Rivera J, Fernandez-del Castillo C, Lewandrowski K, Adrie C, Rattner DW, Warshaw AL. Differing roles of nitric oxide in the pathogenesis of acute edematous versus necrotizing pancreatitis. Surgery. 1997 Jan; 121(1):23-30.
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  66. Rattner DW, Fernandez-del Castillo C, Brugge WR, Warshaw AL. Defining the criteria for local resection of ampullary neoplasms. Arch Surg. 1996 Apr; 131(4):366-71.
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  67. Rattner DW, Fernandez-del Castillo C, Warshaw AL. Pitfalls of distal pancreatectomy for relief of pain in chronic pancreatitis. Am J Surg. 1996 Jan; 171(1):142-5; discussion 145-6.
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  68. Rall CJ, Rivera JA, Centeno BA, Fernandez-del Castillo C, Rattner DW, Warshaw AL, Rustgi AK. Peritoneal exfoliative cytology and Ki-ras mutational analysis in patients with pancreatic adenocarcinoma. Cancer Lett. 1995 Nov 6; 97(2):203-11.
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  69. Bassi D, Kollias N, Fernandez-del Castillo C, Foitzik T, Warshaw AL, Rattner DW. Impairment of pancreatic microcirculation correlates with the severity of acute experimental pancreatitis. J Am Coll Surg. 1994 Sep; 179(3):257-63.
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  70. Foitzik T, Fernandez-del Castillo C, Lewandrowski KB, Rattner DW, Herfarth C, Warshaw AL. [Trypsinogen activation peptides in acute pancreatitis. Experimental data and clinical implications]. Chirurg. 1994 Mar; 65(3):186-9.
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  71. Foitzik T, Bassi DG, Schmidt J, Lewandrowski KB, Fernandez-del Castillo C, Rattner DW, Warshaw AL. Intravenous contrast medium accentuates the severity of acute necrotizing pancreatitis in the rat. Gastroenterology. 1994 Jan; 106(1):207-14.
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  72. Harringer W, Fernandez-del Castillo C, Rattner DW, Guerrero JL, Warshaw AL, Vlahakes GJ. Evaluation and validation of microsphere technique for determination of pancreatic blood flow. Am J Physiol. 1993 Sep; 265(3 Pt 1):G587-94.
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  73. Schmidt J, Fernandez-del Castillo C, Rattner DW, Lewandrowski KB, Messmer K, Warshaw AL. Hyperoncotic ultrahigh molecular weight dextran solutions reduce trypsinogen activation, prevent acinar necrosis, and lower mortality in rodent pancreatitis. Am J Surg. 1993 Jan; 165(1):40-4; discussion 45.
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  74. Schmidt J, Lewandrowski K, Fernandez-del Castillo C, Mandavilli U, Compton CC, Warshaw AL, Rattner DW. Histopathologic correlates of serum amylase activity in acute experimental pancreatitis. Dig Dis Sci. 1992 Sep; 37(9):1426-33.
    View in: PubMed
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