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Last Name
Institution

Hava Avraham, PH.D.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Rn 325
99 Brookline Ave
Boston MA 02215
Phone617/667-0073
Fax617/975-6373

 Overview 
 overview
The major goals of my early career have been to conduct basic research to identify novel genes and pathways regulating hematopoiesis. During the last 15 years, my focus has been to determine the role of these genes in pathways in malignancy. My research is in the area of signaling mechanisms that are essential for normal tissue growth and development, but are perturbed in cancer. Specifically, my lab has focused on signaling pathways of tyrosine kinases, such as CSK, CHK, SRC, FAK, RAFTK/Pyk2, ErbB-2 and VEGF receptors in breast cancer cells and the identification of molecular mechanisms important in breast cancer tumorigenesis and breast cancer metastasis to the brain.
In addition, my recent focus is to study the molecular mechanisms for the disproportionate incidence of triple-negative breast cancer (TNBC), characterized by a lack of expression of the estrogen receptor, progesterone receptor and Her2/ErbB2, to be more prevalent in African American (AA) and Hispanic women, as compared to Caucasian women. Elucidation of novel mechanisms, and identification of novel biomarkers, endogenous risk factors, and their targets that may contribute to the increased mortality of AA women with breast cancer, is of high importance for reducing racial disparities in breast cancer. Specifically, we have investigated the prostanoid signaling pathways in TNBC tumor cells from AA and Caucasian women.

The main topics that are studied in the lab are:

1. COX-2 and prostaglandin EP receptor expression in African American A breast cancer patients, and the potential of COX-2 inhibitors in inhibiting TNBC using in vitro and in vivo models.
2. Signal transduction pathways mediated by ErbB kinases, VEGF receptors, Src kinases, Csk/CHK kinases and FAK/RAFTK/Pyk2 kinases in breast cancer cells and their role in tumorigenesis and breast cancer metastasis.
3. Molecular mechanisms for breast cancer metastases to the brain.
4. VEGF-VEGFR 1 autocrine survival system and its role in chemotherapy resistance.
5. Role of BRCA1 and oxidative stress in sporadic and inherited breast cancer.
6. The role of Kelch related proteins, such as Mayven, Mrp2 and NRP/B, in cytoskeleton reorganization during invasion and migration of normal cells and tumor cells.

In addition I received NIH K18 award on stem cells. Therefore during the last several years, I have investigated new pathways that are important in hematopoietic and neural stem cell survival and self renewal, specifically focusing on the endocannabinoid system.


 Mentoring 
 completed student projects
Characterization of Novel Associations of BRCA1 with downstream targets in response to oxidative stress
Summer, 06/20/05 - 08/12/05

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Avraham HK, Jiang S, Fu Y, Nakshatri H, Ovadia H, Avraham S. Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain. J Pathol. 2014 Feb; 232(3):369-81.
    View in: PubMed
  2. Avraham HK, Jiang S, Fu Y, Rockenstein E, Makriyannis A, Zvonok A, Masliah E, Avraham S. The cannabinoid CB2 receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis. Br J Pharmacol. 2014 Jan; 171(2):468-79.
    View in: PubMed
  3. Li H, Wood JT, Whitten KM, Vadivel SK, Seng S, Makriyannis A, Avraham HK. Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells. Br J Pharmacol. 2013 Oct; 170(3):489-505.
    View in: PubMed
  4. Rodriguez PL, Jiang S, Fu Y, Avraham S, Avraham HK. The proinflammatory peptide substance P promotes blood-brain barrier breaching by breast cancer cells through changes in microvascular endothelial cell tight junctions. Int J Cancer. 2014 Mar 1; 134(5):1034-44.
    View in: PubMed
  5. Jiang S, Fu Y, Avraham HK. Regulation of hematopoietic stem cell trafficking and mobilization by the endocannabinoid system. Transfusion. 2011 Nov; 51 Suppl 4:65S-71S.
    View in: PubMed
  6. Arshad F, Wang L, Sy C, Avraham S, Avraham HK. Blood-brain barrier integrity and breast cancer metastasis to the brain. Patholog Res Int. 2010; 2011:920509.
    View in: PubMed
  7. Jiang S, Zagozdzon R, Jorda MA, Parmar K, Fu Y, Williams JS, Wood JA, Makriyannis A, Banu N, Avraham S, Groopman JE, Avraham HK. Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. J Biol Chem. 2010 Nov 12; 285(46):35471-8.
    View in: PubMed
  8. Seng S, Avraham HK, Birrane G, Jiang S, Avraham S. Nuclear matrix protein (NRP/B) modulates the nuclear factor (Erythroid-derived 2)-related 2 (NRF2)-dependent oxidative stress response. J Biol Chem. 2010 Aug 20; 285(34):26190-8.
    View in: PubMed
  9. Jiang S, Lee BC, Fu Y, Avraham S, Lim B, Avraham HK. Reconstitution of mammary epithelial morphogenesis by murine embryonic stem cells undergoing hematopoietic stem cell differentiation. PLoS One. 2010; 5(3):e9707.
    View in: PubMed
  10. Li H, Sekine M, Tung N, Avraham HK. Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin. Mol Cancer Res. 2010 Mar; 8(3):407-20.
    View in: PubMed
  11. Li H, Sekine M, Seng S, Avraham S, Avraham HK. BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses. PLoS One. 2009; 4(9):e7091.
    View in: PubMed
  12. Tiburu EK, Bowman AL, Struppe JO, Janero DR, Avraham HK, Makriyannis A. Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes. Biochim Biophys Acta. 2009 May; 1788(5):1159-67.
    View in: PubMed
  13. Seng S, Avraham HK, Birrane G, Jiang S, Li H, Katz G, Bass CE, Zagozdzon R, Avraham S. NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors. Oncogene. 2009 Jan 22; 28(3):378-89.
    View in: PubMed
  14. Lu TS, Avraham HK, Seng S, Tachado SD, Koziel H, Makriyannis A, Avraham S. Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. J Immunol. 2008 Nov 1; 181(9):6406-16.
    View in: PubMed
  15. Hinton CV, Avraham S, Avraham HK. Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Clin Exp Metastasis. 2010 Feb; 27(2):97-105.
    View in: PubMed
  16. Hinton CV, Avraham S, Avraham HK. Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis. J Cell Mol Med. 2008 Sep-Oct; 12(5A):1517-26.
    View in: PubMed
  17. Zagozdzon R, Fu Y, Avraham HK. Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma. Int J Oncol. 2008 Mar; 32(3):619-23.
    View in: PubMed
  18. Seng S, Avraham HK, Jiang S, Yang S, Sekine M, Kimelman N, Li H, Avraham S. The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells. Cancer Res. 2007 Sep 15; 67(18):8596-604.
    View in: PubMed
  19. Jiang S, Fu Y, Williams J, Wood J, Pandarinathan L, Avraham S, Makriyannis A, Avraham S, Avraham HK. Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS One. 2007; 2(7):e641.
    View in: PubMed
  20. Lee TH, Seng S, Sekine M, Hinton C, Fu Y, Avraham HK, Avraham S. Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1. PLoS Med. 2007 Jun; 4(6):e186.
    View in: PubMed
  21. Tiburu EK, Bass CE, Struppe JO, Lorigan GA, Avraham S, Avraham HK. Structural divergence among cannabinoids influences membrane dynamics: a 2H solid-state NMR analysis. Biochim Biophys Acta. 2007 Sep; 1768(9):2049-59.
    View in: PubMed
  22. Jiang S, Seng S, Avraham HK, Fu Y, Avraham S. Process elongation of oligodendrocytes is promoted by the Kelch-related protein MRP2/KLHL1. J Biol Chem. 2007 Apr 20; 282(16):12319-29.
    View in: PubMed
  23. Fu Y, Zagozdzon R, Avraham R, Avraham HK. CHK negatively regulates Lyn kinase and suppresses pancreatic cancer cell invasion. Int J Oncol. 2006 Dec; 29(6):1453-8.
    View in: PubMed
  24. Lee TH, Seng S, Li H, Kennel SJ, Avraham HK, Avraham S. Integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells: role of alpha6beta1 integrin in angiogenesis. J Biol Chem. 2006 Dec 29; 281(52):40450-60.
    View in: PubMed
  25. Seng S, Avraham HK, Jiang S, Venkatesh S, Avraham S. KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner. Mol Cell Biol. 2006 Nov; 26(22):8371-84.
    View in: PubMed
  26. Tiburu EK, Karp ES, Birrane G, Struppe JO, Chu S, Lorigan GA, Avraham S, Avraham HK. 31P and 2H relaxation studies of helix VII and the cytoplasmic helix of the human cannabinoid receptors utilizing solid-state NMR techniques. Biochemistry. 2006 Jun 13; 45(23):7356-65.
    View in: PubMed
  27. Kaminski R, Zagozdzon R, Fu Y, Mroz P, Fu W, Seng S, Avraham S, Avraham HK. Role of SRC kinases in Neu-induced tumorigenesis: challenging the paradigm using Csk homologous kinase transgenic mice. Cancer Res. 2006 Jun 1; 66(11):5757-62.
    View in: PubMed
  28. Park I, Avraham HK. Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1. Exp Cell Res. 2006 Jul 1; 312(11):1996-2008.
    View in: PubMed
  29. Lee BC, Avraham S, Imamoto A, Avraham HK. Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice. Blood. 2006 Aug 1; 108(3):904-7.
    View in: PubMed
  30. Jiang S, Avraham HK, Kim TA, Rogers RA, Avraham S. Receptor-type PTP-NP inhibition of Dynamin-1 GTPase activity is associated with neuronal depolarization. Cell Signal. 2006 Sep; 18(9):1439-46.
    View in: PubMed
  31. Kim TA, Jiang S, Seng S, Cha K, Avraham HK, Avraham S. The BTB domain of the nuclear matrix protein NRP/B is required for neurite outgrowth. J Cell Sci. 2005 Dec 1; 118(Pt 23):5537-48.
    View in: PubMed
  32. Zagozdzon R, Kaminski R, Fu Y, Fu W, Bougeret C, Avraham HK. Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner. Cell Signal. 2006 Jun; 18(6):871-81.
    View in: PubMed
  33. Lee BC, Lee TH, Zagozdzon R, Avraham S, Usheva A, Avraham HK. Carboxyl-terminal Src kinase homologous kinase negatively regulates the chemokine receptor CXCR4 through YY1 and impairs CXCR4/CXCL12 (SDF-1alpha)-mediated breast cancer cell migration. Cancer Res. 2005 Apr 1; 65(7):2840-5.
    View in: PubMed
  34. Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S. Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells. Oncogene. 2005 Mar 31; 24(14):2398-409.
    View in: PubMed
  35. Jiang S, Avraham HK, Park SY, Kim TA, Bu X, Seng S, Avraham S. Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven. J Neurochem. 2005 Mar; 92(5):1191-203.
    View in: PubMed
  36. Zhang J, Zhu J, Bu X, Cushion M, Kinane TB, Avraham H, Koziel H. Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. Mol Biol Cell. 2005 Feb; 16(2):824-34.
    View in: PubMed
  37. Avraham HK, Jiang S, Lee TH, Prakash O, Avraham S. HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells. J Immunol. 2004 Nov 15; 173(10):6228-33.
    View in: PubMed
  38. Kim SO, Avraham S, Jiang S, Zagozdzon R, Fu Y, Avraham HK. Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors. Cancer. 2004 Sep 1; 101(5):1018-27.
    View in: PubMed
  39. Melendez J, Turner C, Avraham H, Steinberg SF, Schaefer E, Sussman MA. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem. 2004 Dec 17; 279(51):53516-23.
    View in: PubMed
  40. Liang XQ, Avraham HK, Jiang S, Avraham S. Genetic alterations of the NRP/B gene are associated with human brain tumors. Oncogene. 2004 Aug 5; 23(35):5890-900.
    View in: PubMed
  41. Price DJ, Avraham S, Jiang S, Fu Y, Avraham HK. Role of the aging vasculature and Erb B-2 signaling in epidermal growth factor-dependent intravasion of breast carcinoma cells. Cancer. 2004 Jul 1; 101(1):198-205.
    View in: PubMed
  42. Lee BC, Lee TH, Avraham S, Avraham HK. Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells. Mol Cancer Res. 2004 Jun; 2(6):327-38.
    View in: PubMed
  43. Park SY, Avraham HK, Avraham S. RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner. J Biol Chem. 2004 Aug 6; 279(32):33315-22.
    View in: PubMed
  44. Lee BC, Cha K, Avraham S, Avraham HK. Microarray analysis of differentially expressed genes associated with human ovarian cancer. Int J Oncol. 2004 Apr; 24(4):847-51.
    View in: PubMed
  45. Zrihan-Licht S, Avraham S, Jiang S, Fu Y, Avraham HK. Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells. Int J Oncol. 2004 Jan; 24(1):153-9.
    View in: PubMed
  46. Avraham H, Avraham S, Zagozdzon R. Use of antisense oligonucleotide technology to investigate signaling pathways in megakaryocytes. Methods Mol Biol. 2004; 273:397-406.
    View in: PubMed
  47. Kawai H, Li H, Avraham S, Jiang S, Avraham HK. Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. Int J Cancer. 2003 Nov 10; 107(3):353-8.
    View in: PubMed
  48. Takahashi T, Yamashita H, Nagano Y, Nakamura T, Ohmori H, Avraham H, Avraham S, Yasuda M, Matsumoto M. Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. J Biol Chem. 2003 Oct 24; 278(43):42225-33.
    View in: PubMed
  49. Avraham HK, Lee TH, Koh Y, Kim TA, Jiang S, Sussman M, Samarel AM, Avraham S. Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. J Biol Chem. 2003 Sep 19; 278(38):36661-8.
    View in: PubMed
  50. Kim TA, Avraham HK, Koh YH, Jiang S, Park IW, Avraham S. HIV-1 Tat-mediated apoptosis in human brain microvascular endothelial cells. J Immunol. 2003 Mar 1; 170(5):2629-37.
    View in: PubMed
  51. Miralem T, Avraham HK. Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus. Mol Cell Biol. 2003 Jan; 23(2):579-93.
    View in: PubMed
  52. Price D, Park I, Avraham H. Methods for the study of protein-protein interactions in cancer cell biology. Methods Mol Biol. 2003; 218:255-67.
    View in: PubMed
  53. Zagozdzon R, Bougeret C, Fu Y, Avraham HK. Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells. Int J Oncol. 2002 Dec; 21(6):1347-52.
    View in: PubMed
  54. Lee TH, Avraham HK, Jiang S, Avraham S. Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability. J Biol Chem. 2003 Feb 14; 278(7):5277-84.
    View in: PubMed
  55. Kawai H, Li H, Chun P, Avraham S, Avraham HK. Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. Oncogene. 2002 Oct 31; 21(50):7730-9.
    View in: PubMed
  56. Banu N, Avraham S, Avraham HK. P-selectin, and not E-selectin, negatively regulates murine megakaryocytopoiesis. J Immunol. 2002 Oct 15; 169(8):4579-85.
    View in: PubMed
  57. Melendez J, Welch S, Schaefer E, Moravec CS, Avraham S, Avraham H, Sussman MA. Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. J Biol Chem. 2002 Nov 22; 277(47):45203-10.
    View in: PubMed
  58. Kim S, Zagozdzon R, Meisler A, Baleja JD, Fu Y, Avraham S, Avraham H. Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer. J Biol Chem. 2002 Sep 27; 277(39):36465-70.
    View in: PubMed
  59. McShan GD, Zagozdzon R, Park SY, Zrihan-Licht S, Fu Y, Avraham S, Avraham H. Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration. Int J Oncol. 2002 Jul; 21(1):197-205.
    View in: PubMed
  60. Nakamura T, Yamashita H, Nagano Y, Takahashi T, Avraham S, Avraham H, Matsumoto M, Nakamura S. Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases. FEBS Lett. 2002 Jun 19; 521(1-3):190-4.
    View in: PubMed
  61. Li H, Lee TH, Avraham H. A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. J Biol Chem. 2002 Jun 7; 277(23):20965-73.
    View in: PubMed
  62. Price DJ, Avraham S, Feuerstein J, Fu Y, Avraham HK. The invasive phenotype in HMT-3522 cells requires increased EGF receptor signaling through both PI 3-kinase and ERK 1,2 pathways. Cell Commun Adhes. 2002 Mar-Apr; 9(2):87-102.
    View in: PubMed
  63. Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol. 2002 Feb; 22(4):1158-71.
    View in: PubMed
  64. Lee TH, Avraham H, Lee SH, Avraham S. Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells. J Biol Chem. 2002 Mar 22; 277(12):10445-51.
    View in: PubMed
  65. Miralem T, Steinberg R, Price D, Avraham H. VEGF(165) requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells. Oncogene. 2001 Sep 6; 20(39):5511-24.
    View in: PubMed
  66. Bougeret C, Jiang S, Keydar I, Avraham H. Functional analysis of Csk and CHK kinases in breast cancer cells. J Biol Chem. 2001 Sep 7; 276(36):33711-20.
    View in: PubMed
  67. Koziak K, Kaczmarek E, Park SY, Fu Y, Avraham S, Avraham H. RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase. Br J Haematol. 2001 Jul; 114(1):134-40.
    View in: PubMed
  68. Price DJ, Miralem T, Jiang S, Steinberg R, Avraham H. Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth Differ. 2001 Mar; 12(3):129-35.
    View in: PubMed
  69. Avraham H, Avraham S, Taniguchi Y. Receptor protein tyrosine phosphatases in hematopoietic cells. J Hematother Stem Cell Res. 2000 Aug; 9(4):425-32.
    View in: PubMed
  70. Radisavljevic Z, Avraham H, Avraham S. Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric oxide pathway and modulates migration of brain microvascular endothelial cells. J Biol Chem. 2000 Jul 7; 275(27):20770-4.
    View in: PubMed
  71. Park SY, Avraham H, Avraham S. Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation. J Biol Chem. 2000 Jun 30; 275(26):19768-77.
    View in: PubMed
  72. Zrihan-Licht S, Fu Y, Settleman J, Schinkmann K, Shaw L, Keydar I, Avraham S, Avraham H. RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Oncogene. 2000 Mar 2; 19(10):1318-28.
    View in: PubMed
  73. Avraham H, Park SY, Schinkmann K, Avraham S. RAFTK/Pyk2-mediated cellular signalling. Cell Signal. 2000 Mar; 12(3):123-33.
    View in: PubMed
  74. Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. J Biol Chem. 1999 Nov 5; 274(45):32274-8.
    View in: PubMed
  75. Yamashita H, Avraham S, Jiang S, London R, Van Veldhoven PP, Subramani S, Rogers RA, Avraham H. Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J Biol Chem. 1999 Oct 15; 274(42):29897-904.
    View in: PubMed
  76. Banu N, Deng B, Lyman SD, Avraham H. Modulation of haematopoietic progenitor development by FLT-3 ligand. Cytokine. 1999 Sep; 11(9):679-88.
    View in: PubMed
  77. Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H. The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor. Blood. 1999 Jul 15; 94(2):539-49.
    View in: PubMed
  78. Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S. Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell. 1999 Jul; 10(7):2361-75.
    View in: PubMed
  79. Price DJ, Rivnay B, Avraham H. CHK down-regulates SCF/KL-activated Lyn kinase activity in Mo7e megakaryocytic cells. Biochem Biophys Res Commun. 1999 Jun 16; 259(3):611-6.
    View in: PubMed
  80. Yamashita H, Avraham S, Jiang S, Dikic I, Avraham H. The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells. J Biol Chem. 1999 May 21; 274(21):15059-65.
    View in: PubMed
  81. Pandey P, Avraham S, Kumar S, Nakazawa A, Place A, Ghanem L, Rana A, Kumar V, Majumder PK, Avraham H, Davis RJ, Kharbanda S. Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism. J Biol Chem. 1999 Apr 9; 274(15):10140-4.
    View in: PubMed
  82. Avraham H, Price DJ. Regulation of megakaryocytopoiesis and platelet production by tyrosine kinases and tyrosine phosphatases. Methods. 1999 Mar; 17(3):250-64.
    View in: PubMed
  83. Gerwin N, Gonzalo JA, Lloyd C, Coyle AJ, Reiss Y, Banu N, Wang B, Xu H, Avraham H, Engelhardt B, Springer TA, Gutierrez-Ramos JC. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Immunity. 1999 Jan; 10(1):9-19.
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  84. van Os R, Avraham H, Banu N, Mauch PM, Whater J, Yang Y, Du B. Recombinant adeno-associated virus-based vectors provide short-term rather than long-term transduction of primitive hematopoietic stem cells. Stem Cells. 1999; 17(2):117-20.
    View in: PubMed
  85. Deng B, Banu N, Malloy B, Hass P, Wang JF, Cavacini L, Eaton D, Avraham H. An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis. Blood. 1998 Sep 15; 92(6):1981-8.
    View in: PubMed
  86. Zhang Z, Avraham H, Cohen DM. Urea and NaCl differentially regulate FAK and RAFTK/PYK2 in mIMCD3 renal medullary cells. Am J Physiol. 1998 Sep; 275(3 Pt 2):F447-51.
    View in: PubMed
  87. Jiang S, Tulloch AG, Kim TA, Fu Y, Rogers R, Gaskell A, White RA, Avraham H, Avraham S. Characterization and chromosomal localization of PTP-NP-2, a new isoform of protein tyrosine phosphatase-like receptor, expressed on synaptic boutons. Gene. 1998 Jul 30; 215(2):345-59.
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  88. Kim TA, Lim J, Ota S, Raja S, Rogers R, Rivnay B, Avraham H, Avraham S. NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. J Cell Biol. 1998 May 4; 141(3):553-66.
    View in: PubMed
  89. Sato T, Fuse A, Niimi H, Fielder PJ, Avraham H. Binding and regulation of thrombopoietin to human megakaryocytes. Br J Haematol. 1998 Mar; 100(4):704-11.
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  90. Zrihan-Licht S, Deng B, Yarden Y, McShan G, Keydar I, Avraham H. Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation. J Biol Chem. 1998 Feb 13; 273(7):4065-72.
    View in: PubMed
  91. Ganju RK, Dutt P, Wu L, Newman W, Avraham H, Avraham S, Groopman JE. Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK. Blood. 1998 Feb 1; 91(3):791-7.
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  92. Soltoff SP, Avraham H, Avraham S, Cantley LC. Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J Biol Chem. 1998 Jan 30; 273(5):2653-60.
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  93. Avraham S, London R, Tulloch GA, Ellis M, Fu Y, Jiang S, White RA, Painter C, Steinberger AA, Avraham H. Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. Gene. 1997 Dec 19; 204(1-2):5-16.
    View in: PubMed
  94. Wang JF, Ganju RK, Liu ZY, Avraham H, Avraham S, Groopman JE. Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor. Blood. 1997 Nov 1; 90(9):3507-15.
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  95. Avraham S, Avraham H. Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells. Leuk Lymphoma. 1997 Oct; 27(3-4):247-56.
    View in: PubMed
  96. Astier A, ManiƩ SN, Avraham H, Hirai H, Law SF, Zhang Y, Golemis EA, Fu Y, Druker BJ, Haghayeghi N, Freedman AS, Avraham S. The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1. J Biol Chem. 1997 Aug 8; 272(32):19719-24.
    View in: PubMed
  97. Raja S, Avraham S, Avraham H. Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism. J Biol Chem. 1997 Apr 18; 272(16):10941-7.
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  98. Hiregowdara D, Avraham H, Fu Y, London R, Avraham S. Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin. J Biol Chem. 1997 Apr 18; 272(16):10804-10.
    View in: PubMed
  99. Ganju RK, Hatch WC, Avraham H, Ona MA, Druker B, Avraham S, Groopman JE. RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes. J Exp Med. 1997 Mar 17; 185(6):1055-63.
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  100. Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. J Biol Chem. 1997 Feb 28; 272(9):5915-20.
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  101. ManiƩ SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS. Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. J Biol Chem. 1997 Feb 14; 272(7):4230-6.
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  102. Zrihan-Licht S, Lim J, Keydar I, Sliwkowski MX, Groopman JE, Avraham H. Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells. J Biol Chem. 1997 Jan 17; 272(3):1856-63.
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  103. Astier A, Avraham H, Manie SN, Groopman J, Canty T, Avraham S, Freedman AS. The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. J Biol Chem. 1997 Jan 3; 272(1):228-32.
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  104. Salgia R, Avraham S, Pisick E, Li JL, Raja S, Greenfield EA, Sattler M, Avraham H, Griffin JD. The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells. J Biol Chem. 1996 Dec 6; 271(49):31222-6.
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  105. Li J, Avraham H, Rogers RA, Raja S, Avraham S. Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes. Blood. 1996 Jul 15; 88(2):417-28.
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  106. Nimer S, Zhang J, Avraham H, Miyazaki Y. Transcriptional regulation of interleukin-3 expression in megakaryocytes. Blood. 1996 Jul 1; 88(1):66-74.
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  107. Banu N, Price DJ, London R, Deng B, Mark M, Godowski PJ, Avraham H. Modulation of megakaryocytopoiesis by human macrophage-stimulating protein, the ligand for the RON receptor. J Immunol. 1996 Apr 15; 156(8):2933-40.
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  108. Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. Proc Natl Acad Sci U S A. 1996 Mar 5; 93(5):1988-92.
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  109. Banu N, Wang JF, Deng B, Groopman JE, Avraham H. Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand. Blood. 1995 Aug 15; 86(4):1331-8.
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  110. Avraham H, Ellis MH, Jhun BH, Raja S, Chalasani D, Avraham S. Tyrosine kinases in megakaryocytopoiesis. Stem Cells. 1995 Jul; 13(4):380-92.
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  111. Jhun BH, Rivnay B, Price D, Avraham H. The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit. J Biol Chem. 1995 Apr 21; 270(16):9661-6.
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  112. Ellis MH, Avraham H, Groopman JE. The regulation of megakaryocytopoiesis. Blood Rev. 1995 Mar; 9(1):1-6.
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  113. Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. J Biol Chem. 1995 Jan 27; 270(4):1833-42.
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  114. Jiang S, Levine JD, Fu Y, Deng B, London R, Groopman JE, Avraham H. Cytokine production by primary bone marrow megakaryocytes. Blood. 1994 Dec 15; 84(12):4151-6.
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  115. Grabarek J, Groopman JE, Lyles YR, Jiang S, Bennett L, Zsebo K, Avraham H. Human kit ligand (stem cell factor) modulates platelet activation in vitro. J Biol Chem. 1994 Aug 26; 269(34):21718-24.
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  116. Avraham H, Erdos G, Gazitt Y. Differential expression and subcellular-localization of protein-kinase-C, alpha, gamma, delta, xi and zeta isoforms in agf T-cells - modification during pma-induced differentiation. Int J Oncol. 1994 Aug; 5(2):237-41.
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  117. Avraham H, Banu N, Scadden DT, Abraham J, Groopman JE. Modulation of megakaryocytopoiesis by human basic fibroblast growth factor. Blood. 1994 Apr 15; 83(8):2126-32.
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  118. Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H. Identification and characterization of a novel tyrosine kinase from megakaryocytes. J Biol Chem. 1994 Jan 14; 269(2):1068-74.
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  119. Hauser C, Avraham S, Avraham H. Association of rho proteins with the mitochondria organelle. Int J Oncol. 1993 Dec; 3(6):1103-10.
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  120. Avraham H. Regulation of megakaryocytopoiesis. Stem Cells. 1993 Nov; 11(6):499-510.
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  121. Avraham H, Cowley S, Chi SY, Jiang S, Groopman JE. Characterization of adhesive interactions between human endothelial cells and megakaryocytes. J Clin Invest. 1993 Jun; 91(6):2378-84.
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  122. Avraham H, Scadden DT, Chi S, Broudy VC, Zsebo KM, Groopman JE. Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand. Blood. 1992 Oct 1; 80(7):1679-84.
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  123. Cowley SA, Groopman JE, Avraham H. Effects of transforming growth factor beta on megakaryocytic cell fusion and endomitosis. Int J Cell Cloning. 1992 Jul; 10(4):223-31.
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  124. Avraham H, Vannier E, Chi SY, Dinarello CA, Groopman JE. Cytokine gene expression and synthesis by human megakaryocytic cells. Int J Cell Cloning. 1992 Mar; 10(2):70-9.
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  125. Avraham H, Vannier E, Cowley S, Jiang SX, Chi S, Dinarello CA, Zsebo KM, Groopman JE. Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells. Blood. 1992 Jan 15; 79(2):365-71.
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  126. Avraham S, Avraham H, Austen KF, Stevens RL. Negative and positive cis-acting elements in the promoter of the mouse gene that encodes the serine/glycine-rich peptide core of secretory granule proteoglycans. J Biol Chem. 1992 Jan 5; 267(1):610-7.
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  127. Avraham H. rho gene amplification and malignant transformation. Biochem Biophys Res Commun. 1990 Apr 16; 168(1):114-24.
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  128. Avraham H, Avraham S, Bernstein SC. A rapid procedure for cell colony hybridization using DNA probes. Anal Biochem. 1989 Jun; 179(2):217-21.
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  129. Avraham H, Weinberg RA. Characterization and expression of the human rhoH12 gene product. Mol Cell Biol. 1989 May; 9(5):2058-66.
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  130. Berrebi A, Eshhar Z, Linder S, Guedj L, Avraham H. RAB-1: a new monoclonal antibody to leukemic hairy cells. Leuk Res. 1986; 10(9):1071-8.
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  131. Avraham H, Golenser J, Gazitt Y, Spira DT, Sulitzeanu D. A highly sensitive solid-phase radioimmunoassay for the assay of Plasmodium falciparum antigens and antibodies. J Immunol Methods. 1982 Aug 27; 53(1):61-8.
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