Hava Avraham, PH.D.
|Title||Associate Professor of Medicine|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Beth Israel Deaconess Medical Center|
99 Brookline Ave
Boston MA 02215
The major goals of my early career have been to conduct basic research to identify novel genes and pathways regulating hematopoiesis. During the last 15 years, my focus has been to determine the role of these genes in pathways in malignancy. My research is in the area of signaling mechanisms that are essential for normal tissue growth and development, but are perturbed in cancer. Specifically, my lab has focused on signaling pathways of tyrosine kinases, such as CSK, CHK, SRC, FAK, RAFTK/Pyk2, ErbB-2 and VEGF receptors in breast cancer cells and the identification of molecular mechanisms important in breast cancer tumorigenesis and breast cancer metastasis to the brain.
In addition, my recent focus is to study the molecular mechanisms for the disproportionate incidence of triple-negative breast cancer (TNBC), characterized by a lack of expression of the estrogen receptor, progesterone receptor and Her2/ErbB2, to be more prevalent in African American (AA) and Hispanic women, as compared to Caucasian women. Elucidation of novel mechanisms, and identification of novel biomarkers, endogenous risk factors, and their targets that may contribute to the increased mortality of AA women with breast cancer, is of high importance for reducing racial disparities in breast cancer. Specifically, we have investigated the prostanoid signaling pathways in TNBC tumor cells from AA and Caucasian women.
The main topics that are studied in the lab are:
1. COX-2 and prostaglandin EP receptor expression in African American A breast cancer patients, and the potential of COX-2 inhibitors in inhibiting TNBC using in vitro and in vivo models.
2. Signal transduction pathways mediated by ErbB kinases, VEGF receptors, Src kinases, Csk/CHK kinases and FAK/RAFTK/Pyk2 kinases in breast cancer cells and their role in tumorigenesis and breast cancer metastasis.
3. Molecular mechanisms for breast cancer metastases to the brain.
4. VEGF-VEGFR 1 autocrine survival system and its role in chemotherapy resistance.
5. Role of BRCA1 and oxidative stress in sporadic and inherited breast cancer.
6. The role of Kelch related proteins, such as Mayven, Mrp2 and NRP/B, in cytoskeleton reorganization during invasion and migration of normal cells and tumor cells.
In addition I received NIH K18 award on stem cells. Therefore during the last several years, I have investigated new pathways that are important in hematopoietic and neural stem cell survival and self renewal, specifically focusing on the endocannabinoid system.
Characterization of Novel Associations of BRCA1 with downstream targets in response to oxidative stress
Summer, 06/20/05 - 08/12/05
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