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Keywords
Last Name
Institution

Peter Howard Stone, M.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Cardiovascular Division
75 Francis St
Boston MA 02115
Phone857/307-1965
Fax857/307-1955

 Mentoring 
 completed student projects
Vascular Basis for the Treatmnet of Myocardial Ischemia
Part Time/Continuation, 09/01/99 - 05/30/00
Vascular Basis for the Treatmnet of Myocardial Ischemia
Summer/Continuation, 06/01/99 - 08/31/99
Vascular Basis for the Treatmnet of Myocardial Ischemia
Part Time, 09/07/98 - 06/30/99

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Koskinas KC, Chatzizisis YS, Papafaklis MI, Coskun AU, Baker AB, Jarolim P, Antoniadis A, Edelman ER, Stone PH, Feldman CL. Synergistic effect of local endothelial shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque progression and composition in pigs. Int J Cardiol. 2013 Nov 30; 169(6):394-401.
    View in: PubMed
  2. Bourantas CV, Papafaklis MI, Athanasiou L, Kalatzis FG, Naka KK, Siogkas PK, Takahashi S, Saito S, Fotiadis DI, Feldman CL, Stone PH, Michalis LK. A new methodology for accurate 3-dimensional coronary artery reconstruction using routine intravascular ultrasound and angiographic data: implications for widespread assessment of endothelial shear stress in humans. EuroIntervention. 2013 Sep 22; 9(5):582-93.
    View in: PubMed
  3. Wimmer NJ, Scirica BM, Stone PH. The Clinical Significance of Continuous ECG (Ambulatory ECG or Holter) Monitoring of the ST-Segment to Evaluate Ischemia: A Review. Prog Cardiovasc Dis. 2013 Sep-Oct; 56(2):195-202.
    View in: PubMed
  4. Koskinas KC, Sukhova GK, Baker AB, Papafaklis MI, Chatzizisis YS, Coskun AU, Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi GP, Libby P, Edelman ER, Feldman CL, Stone PH. Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1494-504.
    View in: PubMed
  5. Sakamoto S, Takahashi S, Coskun AU, Papafaklis MI, Takahashi A, Saito S, Stone PH, Feldman CL. Relation of distribution of coronary blood flow volume to coronary artery dominance. Am J Cardiol. 2013 May 15; 111(10):1420-4.
    View in: PubMed
  6. Stone PH. Ischemia dictates outcome, not symptoms. J Am Coll Cardiol. 2013 Feb 19; 61(7):712-3.
    View in: PubMed
  7. Wimmer NJ, Stone PH. Anti-anginal and anti-ischemic effects of late sodium current inhibition. Cardiovasc Drugs Ther. 2013 Feb; 27(1):69-77.
    View in: PubMed
  8. Wentzel JJ, Chatzizisis YS, Gijsen FJ, Giannoglou GD, Feldman CL, Stone PH. Endothelial shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling: current understanding and remaining questions. Cardiovasc Res. 2012 Nov 1; 96(2):234-43.
    View in: PubMed
  9. Stone PH, Saito S, Takahashi S, Makita Y, Nakamura S, Kawasaki T, Takahashi A, Katsuki T, Nakamura S, Namiki A, Hirohata A, Matsumura T, Yamazaki S, Yokoi H, Tanaka S, Otsuji S, Yoshimachi F, Honye J, Harwood D, Reitman M, Coskun AU, Papafaklis MI, Feldman CL. Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION Study. Circulation. 2012 Jul 10; 126(2):172-81.
    View in: PubMed
  10. Takahashi S, Papafaklis MI, Sakamoto S, Antoniadis AP, Coskun AU, Feldman CL, Stone PH. The effect of statins on high-risk atherosclerotic plaque associated with low endothelial shear stress. Curr Opin Lipidol. 2011 Oct; 22(5):358-64.
    View in: PubMed
  11. Stone PH, Feldman CL. In vivo assessment of the risk profile of evolving individual coronary plaques: a step closer. Circulation. 2011 Aug 16; 124(7):763-5.
    View in: PubMed
  12. Stone PH. Allopurinol a new anti-ischemic role for an old drug. J Am Coll Cardiol. 2011 Aug 16; 58(8):829-30.
    View in: PubMed
  13. Doorey A, Denenberg B, Sagar V, Hanna T, Newman J, Stone PH. Comparison of myocardial ischemia during intense mental stress using flight simulation in airline pilots with coronary artery disease to that produced with conventional mental and treadmill exercise stress testing. Am J Cardiol. 2011 Sep 1; 108(5):651-7.
    View in: PubMed
  14. Chatzizisis YS, Baker AB, Sukhova GK, Koskinas KC, Papafaklis MI, Beigel R, Jonas M, Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Feldman CL, Edelman ER, Stone PH. Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs. Circulation. 2011 Feb 15; 123(6):621-30.
    View in: PubMed
  15. Szumita PM, Baroletti S, Avery KR, Massaro AF, Hou PC, Pierce CD, Henderson GV, Stone PH, Scirica BM. Implementation of a Hospital-wide Protocol for Induced Hypothermia Following Successfully Resuscitated Cardiac Arrest. Crit Pathw Cardiol. 2010 Dec; 9(4):216-20.
    View in: PubMed
  16. Papafaklis MI, Koskinas KC, Chatzizisis YS, Stone PH, Feldman CL. In-vivo assessment of the natural history of coronary atherosclerosis: vascular remodeling and endothelial shear stress determine the complexity of atherosclerotic disease progression. Curr Opin Cardiol. 2010 Nov; 25(6):627-38.
    View in: PubMed
  17. Stone PH, Feldman CL. In vivo assessment of local intravascular hemodynamics and arterial morphology to investigate vascular outcomes: a growing field coming of age. JACC Cardiovasc Interv. 2010 Nov; 3(11):1199-201.
    View in: PubMed
  18. Baker AB, Chatzizisis YS, Beigel R, Jonas M, Stone BV, Coskun AU, Maynard C, Rogers C, Koskinas KC, Feldman CL, Stone PH, Edelman ER. Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine. Atherosclerosis. 2010 Dec; 213(2):436-42.
    View in: PubMed
  19. Stone PH, Chaitman BR, Stocke K, Sano J, DeVault A, Koch GG. The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease. J Am Coll Cardiol. 2010 Sep 14; 56(12):934-42.
    View in: PubMed
  20. Luttmann-Gibson H, Suh HH, Coull BA, Dockery DW, Sarnat SE, Schwartz J, Stone PH, Gold DR. Systemic inflammation, heart rate variability and air pollution in a cohort of senior adults. Occup Environ Med. 2010 Sep; 67(9):625-30.
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  21. Koskinas KC, Feldman CL, Chatzizisis YS, Coskun AU, Jonas M, Maynard C, Baker AB, Papafaklis MI, Edelman ER, Stone PH. Natural history of experimental coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: a serial, in vivo intravascular ultrasound study. Circulation. 2010 May 18; 121(19):2092-101.
    View in: PubMed
  22. Zanobetti A, Gold DR, Stone PH, Suh HH, Schwartz J, Coull BA, Speizer FE. Reduction in heart rate variability with traffic and air pollution in patients with coronary artery disease. Environ Health Perspect. 2010 Mar; 118(3):324-30.
    View in: PubMed
  23. Stone PH. Current selection of optimal prosthetic aortic valve replacement in middle-aged patients: still dealer's choice. J Am Coll Cardiol. 2009 Nov 10; 54(20):1869-71.
    View in: PubMed
  24. Koskinas KC, Chatzizisis YS, Baker AB, Edelman ER, Stone PH, Feldman CL. The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque. Curr Opin Cardiol. 2009 Nov; 24(6):580-90.
    View in: PubMed
  25. Ramkumar PG, Mitsouras D, Feldman CL, Stone PH, Rybicki FJ. New advances in cardiac computed tomography. Curr Opin Cardiol. 2009 Nov; 24(6):596-603.
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  26. Francis JL, Weinstein AA, Krantz DS, Haigney MC, Stein PK, Stone PH, Gottdiener JS, Kop WJ. Association between symptoms of depression and anxiety with heart rate variability in patients with implantable cardioverter defibrillators. Psychosom Med. 2009 Oct; 71(8):821-7.
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  27. Zanobetti A, Stone PH, Speizer FE, Schwartz JD, Coull BA, Suh HH, Nearing BD, Mittleman MA, Verrier RL, Gold DR. T-wave alternans, air pollution and traffic in high-risk subjects. Am J Cardiol. 2009 Sep 1; 104(5):665-70.
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  28. Gibson CM, Pride YB, Buros JL, Ciaglo LN, Morrow DA, Scirica BM, Stone PH. Timing and duration of myocardial ischemia on Holter monitoring following percutaneous coronary intervention and their association with clinical outcomes (a PROTECT-TIMI 30 Substudy Analysis). Am J Cardiol. 2009 Jul 1; 104(1):36-40.
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  29. Scirica BM, Morrow DA, Budaj A, Dalby AJ, Mohanavelu S, Qin J, Aroesty J, Hedgepeth CM, Stone PH, Braunwald E. Ischemia detected on continuous electrocardiography after acute coronary syndrome: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis In Myocardial Infarction 36) trial. J Am Coll Cardiol. 2009 Apr 21; 53(16):1411-21.
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  30. Syed Z, Scirica BM, Mohanavelu S, Sung P, Michelson EL, Cannon CP, Stone PH, Stultz CM, Guttag JV. Relation of death within 90 days of non-ST-elevation acute coronary syndromes to variability in electrocardiographic morphology. Am J Cardiol. 2009 Feb 1; 103(3):307-11.
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  31. Stone PH. Ranolazine: new paradigm for management of myocardial ischemia, myocardial dysfunction, and arrhythmias. Cardiol Clin. 2008 Nov; 26(4):603-14.
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  32. Chuang KJ, Coull BA, Zanobetti A, Suh H, Schwartz J, Stone PH, Litonjua A, Speizer FE, Gold DR. Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery disease. Circulation. 2008 Sep 23; 118(13):1314-20.
    View in: PubMed
  33. Chatzizisis YS, Jonas M, Beigel R, Coskun AU, Baker AB, Stone BV, Maynard C, Gerrity RG, Daley W, Edelman ER, Feldman CL, Stone PH. Attenuation of inflammation and expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk coronary atherosclerotic plaques. Atherosclerosis. 2009 Apr; 203(2):387-94.
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  34. Chatzizisis YS, Jonas M, Coskun AU, Beigel R, Stone BV, Maynard C, Gerrity RG, Daley W, Rogers C, Edelman ER, Feldman CL, Stone PH. Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study. Circulation. 2008 Feb 26; 117(8):993-1002.
    View in: PubMed
  35. Steinhauser ML, Stone PH. Risk stratification and management of aortic stenosis with concomitant left ventricular dysfunction. Curr Treat Options Cardiovasc Med. 2007 Dec; 9(6):490-500.
    View in: PubMed
  36. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Stone PH, Feldman CL. Risk stratification of individual coronary lesions using local endothelial shear stress: a new paradigm for managing coronary artery disease. Curr Opin Cardiol. 2007 Nov; 22(6):552-64.
    View in: PubMed
  37. Stone PH. C-reactive protein to identify early risk for development of calcific aortic stenosis: right marker? Wrong time? J Am Coll Cardiol. 2007 Nov 13; 50(20):1999-2001.
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  38. Chen JC, Cavallari JM, Stone PH, Christiani DC. Obesity is a modifier of autonomic cardiac responses to fine metal particulates. Environ Health Perspect. 2007 Jul; 115(7):1002-6.
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  39. Giugliano RP, Wiviott SD, Stone PH, Simon DI, Schweiger MJ, Bouchard A, Leesar MA, Goulder MA, Deitcher SR, McCabe CH, Braunwald E. Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: the ANTHEM-TIMI-32 trial. J Am Coll Cardiol. 2007 Jun 26; 49(25):2398-407.
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  40. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007 Jun 26; 49(25):2379-93.
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  41. Scheer FA, Stone PH, Shea SA. Decreased sleep in heart failure: are medications to blame? Arch Intern Med. 2007 May 28; 167(10):1098-9; author reply 1099-100.
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  42. Stone PH, Coskun AU, Kinlay S, Popma JJ, Sonka M, Wahle A, Yeghiazarians Y, Maynard C, Kuntz RE, Feldman CL. Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study. Eur Heart J. 2007 Mar; 28(6):705-10.
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  43. Deedwania P, Stone PH, Bairey Merz CN, Cosin-Aguilar J, Koylan N, Luo D, Ouyang P, Piotrowicz R, Schenck-Gustafsson K, Sellier P, Stein JH, Thompson PL, Tzivoni D. Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE). Circulation. 2007 Feb 13; 115(6):700-7.
    View in: PubMed
  44. Dockery DW, Stone PH. Cardiovascular risks from fine particulate air pollution. N Engl J Med. 2007 Feb 1; 356(5):511-3.
    View in: PubMed
  45. Adar SD, Gold DR, Coull BA, Schwartz J, Stone PH, Suh H. Focused exposures to airborne traffic particles and heart rate variability in the elderly. Epidemiology. 2007 Jan; 18(1):95-103.
    View in: PubMed
  46. Yiannis YS, Jonas M, Coskun AU, Beigel R, Stone BV, Maynard C, Gerrity RG, Daley W, Rogers C, Edelman ER, Feldman CL, Stone PH. Prediction of the localization of high-risk coronary atherosclerotic plaques based on low endothelial shear stress: A serial intravascular ultrasound and histopathology natural history study. Submitted. 2007; Submitted.
  47. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: Molecular, cellular, and vascular behavior. J Am Coll Cardiol. in press. 2007.
  48. Chen JC, Stone PH, Verrier RL, Nearing BD, MacCallum G, Kim JY, Herrick RF, You J, Zhou H, Christiani DC. Personal coronary risk profiles modify autonomic nervous system responses to air pollution. J Occup Environ Med. 2006 Nov; 48(11):1133-42.
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  49. Gibson CM, Kirtane AJ, Morrow DA, Palabrica TM, Murphy SA, Stone PH, Scirica BM, Jennings LK, Herrmann HC, Cohen DJ, McCabe CH, Braunwald E. Association between thrombolysis in myocardial infarction myocardial perfusion grade, biomarkers, and clinical outcomes among patients with moderate- to high-risk acute coronary syndromes: observations from the randomized trial to evaluate the relative PROTECTion against post-PCI microvascular dysfunction and post-PCI ischemia among antiplatelet and antithrombotic agents-Thrombolysis In Myocardial Infarction 30 (PROTECT-TIMI 30). Am Heart J. 2006 Oct; 152(4):756-61.
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  50. Bhatt AB, Stone PH. Current strategies for the prevention of angina in patients with stable coronary artery disease. Curr Opin Cardiol. 2006 Sep; 21(5):492-502.
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  51. Stone PH. Review: ACE inhibitors reduce mortality and cardiovascular endpoints in stable coronary artery disease. ACP J Club. 2006 Sep-Oct; 145(2):32.
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  52. Luttmann-Gibson H, Suh HH, Coull BA, Dockery DW, Sarnat SE, Schwartz J, Stone PH, Gold DR. Short-term effects of air pollution on heart rate variability in senior adults in Steubenville, Ohio. J Occup Environ Med. 2006 Aug; 48(8):780-8.
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  53. Gibson CM, Morrow DA, Murphy SA, Palabrica TM, Jennings LK, Stone PH, Lui HH, Bulle T, Lakkis N, Kovach R, Cohen DJ, Fish P, McCabe CH, Braunwald E. A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial. J Am Coll Cardiol. 2006 Jun 20; 47(12):2364-73.
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  54. Stone PH, Gratsiansky NA, Blokhin A, Huang IZ, Meng L. Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial. J Am Coll Cardiol. 2006 Aug 1; 48(3):566-75.
    View in: PubMed
  55. Sarnat SE, Suh HH, Coull BA, Schwartz J, Stone PH, Gold DR. Ambient particulate air pollution and cardiac arrhythmia in a panel of older adults in Steubenville, Ohio. Occup Environ Med. 2006 Oct; 63(10):700-6.
    View in: PubMed
  56. Wheeler A, Zanobetti A, Gold DR, Schwartz J, Stone P, Suh HH. The relationship between ambient air pollution and heart rate variability differs for individuals with heart and pulmonary disease. Environ Health Perspect. 2006 Apr; 114(4):560-6.
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  57. Scirica BM, Sabatine MS, Cannon CP, McCabe CH, Braunwald E, Stone PH. Clopidogrel attenuates the complications associated with poor early reperfusion in patients with STEMI undergoing lysis in the CLARITY-IMI 28. J Am Coll Cardiol. 2006; (47:213A).
  58. Scirica BM, Gibson CM, Murphy SA, Morrow DA, Kirtane A, Fish P, McCabe CH, Stone PH. Recurrent ischemia detected by continuous electrocardiogram recording after percutaneous coronary intervention for non-ST-elevation acute coronary syndromes. J Am Coll Cardiol. 2006; (47:182A).
  59. Stone PH. Update in cardiology. Ann Intern Med. 2005 Nov 15; 143(10):737-43.
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  60. Feldman CL, Coskun AU, Yeghiazarians Y, Kinlay S, Wahle A, Olszewski ME, Rossen JD, Sonka M, Popma JJ, Orav J, Kuntz RE, Stone PH. Remodeling characteristics of minimally diseased coronary arteries are consistent along the length of the artery. Am J Cardiol. 2006 Jan 1; 97(1):13-6.
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  61. Rothschild JM, Landrigan CP, Cronin JW, Kaushal R, Lockley SW, Burdick E, Stone PH, Lilly CM, Katz JT, Czeisler CA, Bates DW. The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care. Crit Care Med. 2005 Aug; 33(8):1694-700.
    View in: PubMed
  62. Gold DR, Litonjua AA, Zanobetti A, Coull BA, Schwartz J, MacCallum G, Verrier RL, Nearing BD, Canner MJ, Suh H, Stone PH. Air pollution and ST-segment depression in elderly subjects. Environ Health Perspect. 2005 Jul; 113(7):883-7.
    View in: PubMed
  63. Bambauer KZ, Aupont O, Stone PH, Locke SE, Mullan MG, Colagiovanni J, McLaughlin TJ. The effect of a telephone counseling intervention on self-rated health of cardiac patients. Psychosom Med. 2005 Jul-Aug; 67(4):539-45.
    View in: PubMed
  64. Stone PH, Lloyd-Jones DM, Kinlay S, Frei B, Carlson W, Rubenstein J, Andrews TC, Johnstone M, Sopko G, Cole H, Orav J, Selwyn AP, Creager MA. Effect of intensive lipid lowering, with or without antioxidant vitamins, compared with moderate lipid lowering on myocardial ischemia in patients with stable coronary artery disease: the Vascular Basis for the Treatment of Myocardial Ischemia Study. Circulation. 2005 Apr 12; 111(14):1747-55.
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  65. Stone PH. ST-segment analysis in ambulatory ECG (AECG or Holter) monitoring in patients with coronary artery disease: clinical significance and analytic techniques. Ann Noninvasive Electrocardiol. 2005 Apr; 10(2):263-78.
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  66. Stone PH . ST-segment analysis in ambulatory ECG (AECG or Holter) monitoring in patients with coronary artery disease: clinical significance and analytic techniques. Ann Noninvas Electrocardiol. 2005; 10:263-278.
  67. Feldman CL, Coskun AU, Stone PH. Prediction of Coronary Artery Disease Progression in Humans from Numerically Determined Endothelial Shear Stress. Computers in Cardiology. 2005; 32:105-8.
  68. Stone PH, Gratsiansky N, Blokhin A, Huang I-Z, Meng L for the ERICA Investigators. Anti-anginal efficacy of ranolazine when added to maximal therapy with conventional therapy: The Efficacy of Ranolazine in Chronic Angina (ERICA) Trial. Circulation. 2005.
  69. Coskun AU, Chen C, Stone PH, Feldman CL . Computational fluid dynamics tools can be used to predict the progression of coronary artery disease . Physica A. 2005.
  70. Stone PH. Evaluating cardiovascular pathophysiology and anatomy in atherosclerosis. Am Heart Hosp J. 2005; 3(3):187-92.
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  71. Lockley SW, Cronin JW, Evans EE, Cade BE, Lee CJ, Landrigan CP, Rothschild JM, Katz JT, Lilly CM, Stone PH, Aeschbach D, Czeisler CA. Effect of reducing interns' weekly work hours on sleep and attentional failures. N Engl J Med. 2004 Oct 28; 351(18):1829-37.
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  72. Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, Lilly CM, Stone PH, Lockley SW, Bates DW, Czeisler CA. Effect of reducing interns' work hours on serious medical errors in intensive care units. N Engl J Med. 2004 Oct 28; 351(18):1838-48.
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  73. Stone PH. Triggering myocardial infarction. N Engl J Med. 2004 Oct 21; 351(17):1716-8.
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  74. Zanobetti A, Canner MJ, Stone PH, Schwartz J, Sher D, Eagan-Bengston E, Gates KA, Hartley LH, Suh H, Gold DR. Ambient pollution and blood pressure in cardiac rehabilitation patients. Circulation. 2004 Oct 12; 110(15):2184-9.
    View in: PubMed
  75. Stone PH, Lloyd-Jones DM, Johnstone M, Carlson W, Rubenstein J, Creager M, Frei B, Sopko G, Clark ME, Maccallum G, Kinlay S, Orav J, Selwyn AP. Vascular basis for the treatment of myocardial ischemia study: trial design and baseline characteristics. Am Heart J. 2004 May; 147(5):875-82.
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  76. Desai AS, Stone PH. Risk Stratification in Patients with Unstable Angina and Non-ST-elevation Myocardial Infarction. Curr Treat Options Cardiovasc Med. 2004 Feb; 6(1):3-14.
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  77. Desai A, Stone PH. Risk assessment for patients with unstable angina and non-ST-segment elevation myocardial infarction. Curr Treat Opt in Cardiovasc. 2004; 6:3-14.
  78. Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, Lilly CM, Stone PH, Lockley SW, Bates DW, Czeisler CA. Effect of reducing interns’ work hours on serious medical errors in intensive care units. N Eng J Med. 2004; 351:1838-1848.
  79. Stone PH, Coskun AU, Yeghiazarians Y, Kinlay S, Wahle A, Sonka M, Popma JJ, Kuntz RE, Feldman CL . Coronary plaque progresses in humans only in regions with endothelial shear stress < 12 dynes/cm2, but luminal encroachment depends primarily on inward remodeling. Am J Cardiol. 2004; 94:121E.
  80. Stone PH, Coskun AU, Yeghiazarians Y, Kinlay S, Popma JJ, Kuntz RE, Feldman CL. Prediction of sites of coronary atherosclerosis progression: In vivo profiling of endothelial shear stress, lumen, and outer vessel wall characteristics to predict vascular behavior. Curr Opin Cardiol. 2003 Nov; 18(6):458-70.
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  81. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation. 2003 Oct 14; 108(15):1772-8.
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  82. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation. 2003 Oct 7; 108(14):1664-72.
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  83. Coskun AU, Yeghiazarians Y, Kinlay S, Clark ME, Ilegbusi OJ, Wahle A, Sonka M, Popma JJ, Kuntz RE, Feldman CL, Stone PH. Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans. Catheter Cardiovasc Interv. 2003 Sep; 60(1):67-78.
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  84. Desai AS, Solomon DH, Stone PH, Avorn J. Economic consequences of routine coronary angiography in low- and intermediate-risk patients with unstable angina pectoris. Am J Cardiol. 2003 Aug 15; 92(4):363-7.
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  85. Stone PH, Coskun AU, Kinlay S, Clark ME, Sonka M, Wahle A, Ilegbusi OJ, Yeghiazarians Y, Popma JJ, Orav J, Kuntz RE, Feldman CL. Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study. Circulation. 2003 Jul 29; 108(4):438-44.
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  86. Stone PH, Yeghiazarians Y. Early glycoprotein IIb/IIIa inhibitors in patients with non-ST-segment elevation myocardial infarction: are we ready to open the floodgates? J Am Coll Cardiol. 2003 Jul 2; 42(1):54-6.
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  87. Stone PH, Feldman CL. First steps towards understanding the genetics of atherosclerotic vascular disease: genetic differences in shear stress regulation and vascular remodeling in the rat. VP Watch Online. June 23, 2003. 2003.
  88. Stone PH. Update in cardiology. Ann Intern Med. 2003 Mar 18; 138(6):482-7.
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  89. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. . From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies. Part II. Circulation. 2003; 108:1772-8.
  90. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies. Part I. Circulation. 2003; 108:1664-72.
  91. Coskun AU, Yeghiazarians Y, Kinlay S, Clark ME, Ilegbusi OJ, Wahle A, Sonka M, Popma JJ, Kuntz RE, Feldman CL, Stone PH. Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans . Cathet Cardiovasc Intervent . 2003; 60:67-78.
  92. Sharis PJ, Cannon CP, Rogers WJ, McCabe C, Murphy S, Gibson CM, Stone PH, Braunwald E. Predictors of mortality, coronary angiography, and revascularization in unstable angina pectoris and acute non-ST elevation myocardial infarction (the TIMI III Registry). Am J Cardiol. 2002 Nov 15; 90(10):1154-6.
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  93. Stone PH. A multifaceted search for the presence of high-risk, vulnerable plaque. Curr Opin Cardiol. 2002 Nov; 17(6):613-5.
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  94. Scirica BM, Cannon CP, McCabe CH, Murphy SA, Anderson HV, Rogers WJ, Stone PH, Braunwald E. Prognosis in the thrombolysis in myocardial ischemia III registry according to the Braunwald unstable angina pectoris classification. Am J Cardiol. 2002 Oct 15; 90(8):821-6.
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  95. Verrier RL, Nearing BD, Stone PH. Optimizing ambulatory ECG monitoring of T-wave alternans for arrhythmia risk assessment. Card Electrophysiol Rev. 2002 Sep; 6(3):329-33.
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  96. Verrier RL, Mittleman MA, Stone PH. Air pollution: an insidious and pervasive component of cardiac risk. Circulation. 2002 Aug 20; 106(8):890-2.
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  97. Feldman CL, Ilegbusi OJ, Hu Z, Nesto R, Waxman S, Stone PH. Determination of in vivo velocity and endothelial shear stress patterns with phasic flow in human coronary arteries: a methodology to predict progression of coronary atherosclerosis. Am Heart J. 2002 Jun; 143(6):931-9.
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  98. Kinlay S, Timms T, Clark M, Karam C, Bilodeau T, Ridker PM, Rifai N, Carlson W, Lloyd-Jones DM, Johnstone M, Rubenstein J, Alexander S, Orav J, Stone PH. Comparison of effect of intensive lipid lowering with atorvastatin to less intensive lowering with lovastatin on C-reactive protein in patients with stable angina pectoris and inducible myocardial ischemia. Am J Cardiol. 2002 May 15; 89(10):1205-7.
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  99. Desai MY, Ostfeld R, Stone PH, Helin K. Prinzmetal's angina detected by exercise Tc-99m tetrofosmin SPECT. J Nucl Cardiol. 2002 May-Jun; 9(3):353-4.
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  100. Sheps DS, McMahon RP, Becker L, Carney RM, Freedland KE, Cohen JD, Sheffield D, Goldberg AD, Ketterer MW, Pepine CJ, Raczynski JM, Light K, Krantz DS, Stone PH, Knatterud GL, Kaufmann PG. Mental stress-induced ischemia and all-cause mortality in patients with coronary artery disease: Results from the Psychophysiological Investigations of Myocardial Ischemia study. Circulation. 2002 Apr 16; 105(15):1780-4.
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  101. Yeghiazarians Y, Stone PH. ST-Segment Elevation Myocardial Infarction. Curr Treat Options Cardiovasc Med. 2002 Feb; 4(1):3-23.
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  102. Solomon DH, Ganz DA, Avorn J, Glynn RJ, Knight EL, Gibson CM, Stone PH. Which patients with unstable angina or non-Q-wave myocardial infarction should have immediate cardiac catheterization? A clinical decision rule for predicting who will fail medical therapy. J Clin Epidemiol. 2002 Feb; 55(2):121-8.
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  103. Forest CE, Stone PH, Sokolov AP, Allen MR, Webster MD. Quantifying uncertainties in climate system properties with the use of recent climate observations. Science. 2002 Jan 4; 295(5552):113-7.
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  104. Maxwell AJ, Zapien MP, Pearce GL, MacCallum G, Stone PH. Randomized trial of a medical food for the dietary management of chronic, stable angina. J Am Coll Cardiol. 2002 Jan 2; 39(1):37-45.
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  105. Feldman CH, Ilegbusi OJ, Hu Z, Nesto R, Waxman S, Stone PH. Determination of in Vivo Velocity and Endothelial Shear Stress Patterns with Phasic Flow in Human Coronary Arteries: A Methodology to Predict Progression of Coronary Atherosclerosis. 2002; 143:931-9.
  106. Sharis PJ, Cannon CP, Rogers WJ, McCabe C, Murphy S, Gibson CM, Stone PH, Braunwald E. Predictors of Mortality, Coronary Angiography, and Revascularization in Unstable Angina Pectoris and Acute Non-ST Elevation Myocardial Infarction (the TIMI III Registry). 2002; 90: 1154-1156.
  107. Yeghiazarians Y, Stone PH. ST-Segment Elevation Myocardial Infarction. Curr Treat Opt in Cardiovasc Med. 2002; 4:3-23.
  108. Deedwania PC, Stone PH. Ambulatory electrocardiographic monitoring for myocardial ischemia. Curr Probl Cardiol. 2001 Nov; 26(11):680-727.
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  109. Solomon DH, Stone PH, Glynn RJ, Ganz DA, Gibson CM, Tracy R, Avorn J. Use of risk stratification to identify patients with unstable angina likeliest to benefit from an invasive versus conservative management strategy. J Am Coll Cardiol. 2001 Oct; 38(4):969-76.
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  110. Delemos JA, Cannon CP, Stone PH. Acute Myocardial Infarction. In Rosendorf C (ed). Essential Cardiology. WB Saunders Co. Phil . 2001; 463-501.
  111. Azar RR, Rinfret S, Théroux P, Stone PH, Dakshinamurthy R, Feng YJ, Wu AH, Rangé G, Waters DD. A randomized placebo-controlled trial to assess the efficacy of antiinflammatory therapy with methylprednisolone in unstable angina (MUNA trial). Eur Heart J. 2000 Dec; 21(24):2026-32.
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  112. Feldman CL, Stone PH. Intravascular hemodynamic factors responsible for progression of coronary atherosclerosis and development of vulnerable plaque. Curr Opin Cardiol. 2000 Nov; 15(6):430-40.
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  113. Glasser SP, Frishman W, White WB, Stone P, Johnson MF. Circadian heart rate response to chronotherapy versus conventional therapy in patients with hypertension and myocardial ischemia. Clin Cardiol. 2000 Jul; 23(7):524-9.
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  114. Yeghiazarians Y, Braunstein JB, Askari A, Stone PH. Unstable angina pectoris. N Engl J Med. 2000 Jan 13; 342(2):101-14.
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  115. Yeghiazarins Y, Braunstein JB, Askari A, Stone PH 2000. Unstable Angina. NEJM. 2000; 342: 101-114.
  116. Stone PH. The continuum from endothelial dysfunction to acute coronary syndromes: Enhanced pathophysiologic insights and new opportunities for treatment. Curr Opin Cardiol 2000. 2000; (15: 407-8).
  117. Ketterer MW, Freedland DE, Krantz DS, Kaufmann P, Forman S, Greene A, Raczynski J, Knatterud G, Light K, Carney RM, Stone P, Becker L, Sheps D for the PIMI Investigators. Psychological correlates of mental stress-induced ischemia in the laboratory. The PIMI Study. J Health Psychol. 2000; 5: 75-85.
  118. Cannon CP, Stone PH. Treatment of acute coronary syndromes (myocardial infarction and unstable angina pectoris). In Carruthers GS, Hoffman BB, Melmon KL, Nierenberg DW (eds). Melmon and Morelli’s Clinical Pharmacology: The Principles and Practical Application of Therapeutics. McGraw-Hill. 2000; 131-56.
  119. Stone PH, Thompson B, Zaret BL, Chaitman B, Gibson RS, Schweiger MJ, Steingart R, Kirshenbaum J, Thompson C, Fung A, McCabe CH, Knatterud GL, Braunwald E. Factors associated with failure of medical therapy in patients with unstable angina and non-Q wave myocardial infarction. A TIMI-IIIB database study. Eur Heart J. 1999 Aug; 20(15):1084-93.
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  120. Stone PH, Krantz DS, McMahon RP, Goldberg AD, Becker LC, Chaitman BR, Taylor HA, Cohen JD, Freedland KE, Bertolet BD, Coughlan C, Pepine CJ, Kaufmann PG, Sheps DS. Relationship among mental stress-induced ischemia and ischemia during daily life and during exercise: the Psychophysiologic Investigations of Myocardial Ischemia (PIMI) study. J Am Coll Cardiol. 1999 May; 33(6):1476-84.
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  121. Frishman WH, Glasser S, Stone P, Deedwania PC, Johnson M, Fakouhi TD. Comparison of controlled-onset, extended-release verapamil with amlodipine and amlodipine plus atenolol on exercise performance and ambulatory ischemia in patients with chronic stable angina pectoris. Am J Cardiol. 1999 Feb 15; 83(4):507-14.
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  122. Stone PH, Krantz DS, McMahon RP, Goldberg AD, Becker LC, Chaitman BR, Taylor HA, Cohen JD, Freedland KE, Bertolet BD, Coughlan C, Pepine CJ, Kaufman PG, Sheps DS, for the PIMI Study Group . Relationship among mental stress-induced ischemia during daily life and during exercise: The Psychophysiologic Investigation of Myocardial Ischemia (PIMI) Study. J Am Coll Cardiol. 1999; 33:1476-84.
  123. Sheps DS, McMahon RP, Light KC, Maixner W, Pepine CJ, Cohen DS, McMahon RP, Light KCMaixner W, Pepine CJ, Cohen JD, Goldlberg AD, Bonsall R, Carney R, Stone PH, Sheffield D, Kaufmann PG, and the PIMI Investigators. Low hot pain threshold predicts shorter time to exercise-induced angina: results from the PIMI Study. J Am Coll Cardiol. 1999; 33:1855-62.
  124. Ilegbusi OJ, Hu Z, Nesto R, Waxman S, Cyganski D, Kilian J, Stone PH, Feldman CL . Determination of blood flow and endothelial shear stress in human coronary artery in-vivo. Invas Cardiol. 1999; 11:667-674.
  125. Stone PH, Thompson B, Zaret BL, Chaitman B, Gibson RS, Schweiger MJ, Steingart R, Kirshenbaum J, Thompson C, Fung A, McCabe CH, Knatterud GL, Braunwald E, for the TIMI-IIIB Investigators. Factors associated with failure of medical therapy in patients with unstable angina and non-Q-wave MI: A TIMI-IIIB Database Study. European Heart. 1999; 20:1084-1093.
  126. Stone PH. The Role of Beta-blocker Ca++ channel blockers, and Nitrates in the Treatment of the Acute Coronary Syndromes . The Humana Press, Inc. Totowa NJ. 1999; 337-356.
  127. Stone PH, Godleski JJ . First steps toward understanding the pathophysiologic link between air pollution and cardiac mortality in man. Am Heart J . 1999; (138:804-7).
  128. Bush DE, Fleisher LA, McMahon RP, Pepine CJ, Stone PH, Sopko G, Conti CR, Ouyang P for the ACIP Investigators. Differences in heart rate variability between African-Americans and whites with coronary artery disease and ischemia. J Am Coll Cardiol. 1999; (33 (Suppl A):121 A).
  129. Jacobs SC, Stone PH . Psychological issues. In Charney P (ed) Coronary Artery Disease in Women. Am College Physicians, Phil. 1999; 496-534..
  130. Andrews TC, Parker JD, Jacobs S, Friedman R, Cummings N, MacCallum G, Mannting F, Tofler GH, Carlson W, Muller JE, Stone PH. Effects of therapy with nifedipine GITS or atenolol on mental stress-induced ischemic left ventricular dysfunction. J Am Coll Cardiol. 1998 Nov 15; 32(6):1680-6.
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  131. Kaufmann PG, McMahon RP, Becker LC, Bertolet B, Bonsall R, Chaitman B, Cohen JD, Forman S, Goldberg AD, Freedland K, Ketterer MW, Krantz DS, Pepine CJ, Raczynski J, Stone PH, Taylor H, Knatterud GL, Sheps DS. The Psychophysiological Investigations of Myocardial Ischemia (PIMI) study: objective, methods, and variability of measures. Psychosom Med. 1998 Jan-Feb; 60(1):56-63.
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  132. Bush DE, Fleisher LA, McMahon R, Pepine CJ, Stone PH, Ouyang P . Decreased heart rate variability is associated with increased two year mortality in patients with stable ischemic syndromes. Circulation 1998. 1998; (98 (Suppl I):635).
  133. Stone PH, Chaitman BR, Forman S, Andrews TC, Bittner V, Bourassa MG, Davies RF, Deanfield JE, Frishman W, Goldberg AD, MacCallum G, Ouyang P, Pepine CJ, Pratt CM, Sharaf B, Steingart R, Knatterud GL, Sopko G, Conti CR. Prognostic significance of myocardial ischemia detected by ambulatory electrocardiography, exercise treadmill testing, and electrocardiogram at rest to predict cardiac events by one year (the Asymptomatic Cardiac Ischemia Pilot [ACIP] study) Am J Cardiol. 1997 Dec 1; 80(11):1395-401.
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  134. Berntson GG, Bigger JT, Eckberg DL, Grossman P, Kaufmann PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, van der Molen MW. Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology. 1997 Nov; 34(6):623-48.
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  135. Cannon CP, McCabe CH, Stone PH, Rogers WJ, Schactman M, Thompson BW, Pearce DJ, Diver DJ, Kells C, Feldman T, Williams M, Gibson RS, Kronenberg MW, Ganz LI, Anderson HV, Braunwald E. The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q wave myocardial infarction: results of the TIMI III Registry ECG Ancillary Study. Thrombolysis in Myocardial Ischemia. J Am Coll Cardiol. 1997 Jul; 30(1):133-40.
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  136. Bovill EG, Tracy RP, Knatterud GL, Stone PH, Nasmith J, Gore JM, Thompson BW, Tofler GH, Kleiman NS, Cannon C, Braunwald E. Hemorrhagic events during therapy with recombinant tissue plasminogen activator, heparin, and aspirin for unstable angina (Thrombolysis in Myocardial Ischemia, phase IIIB trial). Am J Cardiol. 1997 Feb 15; 79(4):391-6.
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  137. Cannon CP, McCabe CH, Stone PH, Schactman M, Thompson B, Theroux P, Gibson RS, Feldman T, Kleiman NS, Tofler GH, Muller JE, Chaitman BR, Braunwald E. Circadian variation in the onset of unstable angina and non-Q-wave acute myocardial infarction (the TIMI III Registry and TIMI IIIB). Am J Cardiol. 1997 Feb 1; 79(3):253-8.
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  138. Nosovitsky VA, Ilegbusi OJ, Jiang J, Stone PH, Feldman CL. Effects of curvature and stenosis-like narrowing on wall shear stress in a coronary artery model with phasic flow. Comput Biomed Res. 1997 Feb; 30(1):61-82.
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  139. Verrier RL, Stone PH. Exercise stress testing for T-wave alternans to expose latent electrical instability. J Cardiovasc Electrophysiol. 1997; (8:994-7).
  140. Hochman JS, McCabe CH, Stone PH, Becker RC, Cannon CP, DeFeo-Fraulini T, Thompson B, Steingart R, Knatterud G, Braunwald E, for the TIMI Investigators. Outcome and profile of women and men presenting with acute coronary syndromes: A Report from TIMI IIIB. J Am Coll Cardiol 1997;30:141-8. 1997; 30:141-8.
  141. Sharaf BL, Williams DO, Miele NJ, McMahon RP, Stone PH, Bjerregaard P, Davies R, Goldberg AD, Parks M, Pepine CJ, Sopko G, Conti CR. A detailed angiographic analysis of patients with ambulatory electrocardiographic ischemia: results from the Asymptomatic Cardiac Ischemia Pilot (ACIP) study angiographic core laboratory. J Am Coll Cardiol. 1997 Jan; 29(1):78-84.
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  142. Pepine CJ, Sharaf B, Andrews TC, Forman S, Geller N, Knatterud G, Mahmarian J, Ouyang P, Rogers WJ, Sopko G, Steingart R, Stone PH, Conti CR, for the ACIP Study Group. Relation between clinical, angiographic, and ischemic findings at baseline and ischemia related adverse outcome at 1 year in the Asymptomatic Cardiac Ischemia Pilot Study. J Am Coll Cardiology. 1997; 29:1483-9.
  143. Verrier RL, Stone PH, Pace-Schott EF, Hobson JA . Sleep-related cardiovascular risk: new home-based monitoring technology for improved diagnosis and therapy. Ann Noninvasive Electrocardiol. 1997; 2:158-175.
  144. Cannon CP, McCabe CH, Stone PH, Rogers WJ, Schactman M, Thompson BW, Pearce DJ, Diver DJ, Kells C, Feldman T, Williams M, Gibson RS, Kronenberg MW, Ganz LI, Anderson HV, Braunwald E, for the TIMI III Registry ECG Ancillary Study Investigators. The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q-wave myocardial infarction: Results of the TIMI III Registry ECG Ancillary Study. J Am Coll Cardiology. 1997; 30:133-40.
  145. Goldberg AD, Becker LC, Bonsall R, Cohen JD, Ketterer MW, Kaufman PG, Krantz DS, Light KC, McMahon RP, Noreuil T, Pepine CJ, Raczynski J, Stone PH, Strother D, Taylor H, Sheps DS. Ischemic, hemodynamic, and neurohormonal responses to mental and exercise stress. Experience from the Psychophysiological Investigations of Myocardial Ischemia Study (PIMI). Circulation. 1996 Nov 15; 94(10):2402-9.
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  146. Pasternak RC, Brown LE, Stone PH, Silverman DI, Gibson CM, Sacks FM. Effect of combination therapy with lipid-reducing drugs in patients with coronary heart disease and "normal" cholesterol levels. A randomized, placebo-controlled trial. Harvard Atherosclerosis Reversibility Project (HARP) Study Group. Ann Intern Med. 1996 Oct 1; 125(7):529-40.
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  147. Stone PH, Chaitman BR, McMahon RP, Andrews TC, MacCallum G, Sharaf B, Frishman W, Deanfield JE, Sopko G, Pratt C, Goldberg AD, Rogers WJ, Hill J, Proschan M, Pepine CJ, Bourassa MG, Conti CR. Asymptomatic Cardiac Ischemia Pilot (ACIP) Study. Relationship between exercise-induced and ambulatory ischemia in patients with stable coronary disease. Circulation. 1996 Oct 1; 94(7):1537-44.
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  148. Caracciolo EA, Chaitman BR, Forman SA, Stone PH, Bourassa MG, Sopko G, Geller NL, Conti CR. Diabetics with coronary disease have a prevalence of asymptomatic ischemia during exercise treadmill testing and ambulatory ischemia monitoring similar to that of nondiabetic patients. An ACIP database study. ACIP Investigators. Asymptomatic Cardiac Ischemia Pilot Investigators. Circulation. 1996 Jun 15; 93(12):2097-105.
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  149. Pepine CJ, Andrews T, Deanfield JE, Forman S, Geller N, Hill JA, Pratt C, Rogers WJ, Sopko G, Steingart R, Stone PH, Conti CR. Relation of patient characteristics to cardiac ischemia during daily life activity (an Asymptomatic Cardiac Ischemia Pilot Data Bank Study). Am J Cardiol. 1996 Jun 15; 77(15):1267-72.
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  150. Stone PH, Thompson B, Anderson HV, Kronenberg MW, Gibson RS, Rogers WJ, Diver DJ, Théroux P, Warnica JW, Nasmith JB, Kells C, Kleiman N, McCabe CH, Schactman M, Knatterud GL, Braunwald E. Influence of race, sex, and age on management of unstable angina and non-Q-wave myocardial infarction: The TIMI III registry. JAMA. 1996 Apr 10; 275(14):1104-12.
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  151. Kleiman NS, Anderson HV, Rogers WJ, Theroux P, Thompson B, Stone PH. Comparison of outcome of patients with unstable angina and non-Q-wave acute myocardial infarction with and without prior coronary artery bypass grafting (Thrombolysis in Myocardial Ischemia III Registry). Am J Cardiol. 1996 Feb 1; 77(4):227-31.
    View in: PubMed
  152. Pasternak RC, Brown LE, Stone PH, Silverman DI, Gibson CM, Sacks FM, for the Harvard Atherosclerosis Reversibility Project (HARP) Study Group. Effect of combination therapy with lipid-reducing drugs in patients with coronary heart disease and "normal" cholesterol levels. Ann Intern Med. 1996; 125:529-540.
  153. Stone PH, Sacks FM. Strategies for Secondary Prevention. In Manson JE, Ridker PM, Gaziano JM, Hennekens CH (eds). Prevention of Myocardial Infarction. 1996; 463-510.
  154. Nearing BD, Stone PH, Verrier RL. Frequency response characteristics required for detection of T-wave alternans during ambulatory ECG monitoring. Annals of Noninvasive Electrocardiology. 1996; 1:103-112.
  155. Pratt CM, McMahon RP, Goldstein S, Pepine CJ, Andrews TC, Dyrda I, Frishman WH, Geller NL, Hill JA, Morgan NA, Stone PH, Knatterud GL, Sopko G, Conti CR, for the ACIP Investigators. Comparison of subgroups assigned to medical regimens used to suppress cardiac ischemia (the Asymptomatic Cardiac Ischemia Pilot [ACIP] study). Am J Cardiol 1996;77:1302-1309. 1996; 77:1302-1309.
  156. Verrier RL, Nearing BD, MacCallum G, Stone PH. . Significant T-wave alternans during ambulatory ischemia in patients with stable coronary disease. Annals of Noninvasive Electrocardiology 1996;1:113-120. 1996; 1:113-120.
  157. Cannon C, Ganz L, Stone PH. Complicated myocardial infarction . In Intensive Care Medicine. 1996.
  158. Anderson HV, Cannon CP, Stone PH, Williams DO, McCabe CH, Knatterud GL, Thompson B, Willerson JT, Braunwald E. One-year results of the Thrombolysis in Myocardial Infarction (TIMI) IIIB clinical trial. A randomized comparison of tissue-type plasminogen activator versus placebo and early invasive versus early conservative strategies in unstable angina and non-Q wave myocardial infarction. J Am Coll Cardiol. 1995 Dec; 26(7):1643-50.
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  159. Sacks FM, Gibson CM, Rosner B, Pasternak RC, Stone PH. The influence of pretreatment low density lipoprotein cholesterol concentrations on the effect of hypocholesterolemic therapy on coronary atherosclerosis in angiographic trials. Harvard Atherosclerosis Reversibility Project Research Group. Am J Cardiol. 1995 Sep 28; 76(9):78C-85C.
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  160. Bourassa MG, Pepine CJ, Forman SA, Rogers WJ, Dyrda I, Stone PH, Chaitman BR, Sharaf B, Mahmarian J, Davies RF, et al. Asymptomatic Cardiac Ischemia Pilot (ACIP) study: effects of coronary angioplasty and coronary artery bypass graft surgery on recurrent angina and ischemia. The ACIP investigators. J Am Coll Cardiol. 1995 Sep; 26(3):606-14.
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  161. Chaitman BR, Stone PH, Knatterud GL, Forman SA, Sopko G, Bourassa MG, Pratt C, Rogers WJ, Pepine CJ, Conti CR. Asymptomatic Cardiac Ischemia Pilot (ACIP) study: impact of anti-ischemia therapy on 12-week rest electrocardiogram and exercise test outcomes. The ACIP Investigators. J Am Coll Cardiol. 1995 Sep; 26(3):585-93.
    View in: PubMed
  162. Sacks FM, Stone PH, Gibson CM, Silverman DI, Rosner B, Pasternak RC. Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. J Am Coll Cardiol. 1995 Jun; 25(7):1492-8.
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  163. Hare JM, Stone PH. Exercise training and cardiac rehabilitation in patients with cardiovascular disease. In Kloner (ed.), The Guide to Cardiology (3rd Edition) . Greenwich: LeJacq Communications, Inc.1995 . 1995; 717-728.
  164. Rogers WJ, Bourassa MG, Andrews TC, Bertolet BD, Blumenthal RS, Chaitman BR, Forman SA, Geller NL, Goldberg AD, Habib GB, Masters RG, Moisa RB, Mueller H, Pearce DJ, Pepine CJ, Sopko G, Steingart RM, Stone PH, Knatterud GL, Conti CR for the ACIP Investigators. Asymptomatic Cardiac Ischemia Pilot (ACIP) study: Outcome at 1 year for patients with asymptomatic cardiac ischemia randomized to medical therapy or revascularization. J Am Coll Cardiol. 1995; 26:594-605.
  165. Hauptman PJ, Ting HH, Stone PH. Transplant-associated coronary artery disease: From chronic disease to acute myocardial infarction. Editorial. 1995; (25:545-547).
  166. Nosovitsky VA, Ilegbusi OJ, Jiang J, Stone PH. Effects of curvature and stenosis on velocity and wall shear stress patterns in a coronary artery model with phasic flow. IEEE Proceedings of Computers in Cardiology . 1995.
  167. Jacobs SC, Friedman R, Parker JD, Tofler GH, Jimenez AH, Muller JE, Benson H, Stone PH. Use of skin conductance changes during mental stress testing as an index of autonomic arousal in cardiovascular research. Am Heart J. 1994 Dec; 128(6 Pt 1):1170-7.
    View in: PubMed
  168. Sacks FM, Pasternak RC, Gibson CM, Rosner B, Stone PH. Effect on coronary atherosclerosis of decrease in plasma cholesterol concentrations in normocholesterolaemic patients. Harvard Atherosclerosis Reversibility Project (HARP) Group. Lancet. 1994 Oct 29; 344(8931):1182-6.
    View in: PubMed
  169. Osborne JA, Stone PH. Recent advances in the understanding and management of stable and unstable angina pectoris and asymptomatic myocardial ischemia. Curr Opin Cardiol. 1994 Jul; 9(4):448-56.
    View in: PubMed
  170. Knatterud GL, Bourassa MG, Pepine CJ, Geller NL, Sopko G, Chaitman BR, Pratt C, Stone PH, Davies RF, Rogers WJ, et al. Effects of treatment strategies to suppress ischemia in patients with coronary artery disease: 12-week results of the Asymptomatic Cardiac Ischemia Pilot (ACIP) study. J Am Coll Cardiol. 1994 Jul; 24(1):11-20.
    View in: PubMed
  171. Stone PH. Management of the patient with asymptomatic aortic stenosis. J Card Surg. 1994 Mar; 9(2 Suppl):139-44.
    View in: PubMed
  172. Parker JD, Testa MA, Jimenez AH, Tofler GH, Muller JE, Parker JO, Stone PH. Morning increase in ambulatory ischemia in patients with stable coronary artery disease. Importance of physical activity and increased cardiac demand. Circulation. 1994 Feb; 89(2):604-14.
    View in: PubMed
  173. Sacks FM, Pasternak RC, Gibson CM, Rosner B, Stone PH for the Harvard Atherosclerosis Reversibility Project Group. The effect on coronary atherosclerosis of improving plasma cholesterol levels in patients with normal plasma cholesterol levels. Lancet. 1994; 344:1182-1186.
  174. Osborne JA, Stone PH . Recent advances in the understanding and management of stable and unstable angina pectoris and asymptomatic myocardial ischemia. 1994; 9:448-456..
  175. Parker JD, Jimenez AH, Tofler GH, Muller JE, Parker JO, Stone PH. The morning increase in ambulatory ischemia in patients with stable coronary disease: Importance of physical activity and increased cardiac demand. Circulation . 1994; 89:604-614.
  176. Jacobs SC, Friedman R, Parker JD, Tofler GH, Jimenez AH, Muller JE, Benson H, Stone PH. Skin conductance changes during the mental stress testing: A useful index of autonomic arousal in cardiovascular research. Am Heart J 1994;128:1170-1177. Skin conductance changes during the mental stress testing: A useful index of autonomic arousal in cardiovascular research. Am Heart J. 1994; 128:1170-1177.
  177. The TIMI IIIB Investigators. Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB trial. Circulation . 1994; 89:1545-1556.
  178. Pepine CJ, Geller NL, Knatterud GL, Bourassa MG, Chaitman BR, Davies RF, Day P, Deanfield JE, Goldberg AD, McMahon RP, Mueller H, Ouyang P, Pratt C, Proschan M, Rogers WJ, Selwyn AP, Sharaf B, Sopko G, Stone PH, Conti CR for the ACIP Investigators. The Asymptomatic Cardiac Ischemia Pilot (ACIP). Design of a randomized clinical trial, baseline data and implications for a long-term outcome trial. J Am Coll Cardiol. 1994; 24:1-10.
  179. McMahon RP, Proschan M, Geller NL, Stone PH, Sopko G for the ACIP Investigators. Sample size calculation for clinical trials in which entry criteria and outcomes are counts of events. Statistics in Med. 1994; 13:859-870.
  180. Stone PH. Management of the patient with asymptomatic aortic stenosis. 1994; 9(Suppl):139-144.
  181. Andrews TC, Fenton T, Toyosaki N, Glasser SP, Young PM, MacCallum G, Gibson RS, Shook TL, Stone PH. Subsets of ambulatory myocardial ischemia based on heart rate activity. Circadian distribution and response to anti-ischemic medication. The Angina and Silent Ischemia Study Group (ASIS) Circulation. 1993 Jul; 88(1):92-100.
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  182. Borzak S, Fenton T, Glasser SP, Shook TL, MacCallum G, Young PM, Stone PH. Discordance between effects of anti-ischemic therapy on ambulatory ischemia, exercise performance and anginal symptoms in patients with stable angina pectoris. The Angina and Silent Ischemia Study Group (ASIS). J Am Coll Cardiol. 1993 Jun; 21(7):1605-11.
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  183. Tofler GH, Muller JE, Stone PH, Davies G, Davis VG, Braunwald E. Comparison of long-term outcome after acute myocardial infarction in patients never graduated from high school with that in more educated patients. Multicenter Investigation of the Limitation of Infarct Size (MILIS). Am J Cardiol. 1993 May 1; 71(12):1031-5.
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  184. Stone PH, Gibson CM, Pasternak RC, McManus K, Diaz L, Boucher T, Spears R, Sandor T, Rosner B, Sacks FM. Natural history of coronary atherosclerosis using quantitative angiography in men, and implications for clinical trials of coronary regression. The Harvard Atherosclerosis Reversibility Project Study Group. Am J Cardiol. 1993 Apr 1; 71(10):766-72.
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  185. Gibson CM, Diaz L, Kandarpa K, Sacks FM, Pasternak RC, Sandor T, Feldman C, Stone PH. Relation of vessel wall shear stress to atherosclerosis progression in human coronary arteries. Arterioscler Thromb. 1993 Feb; 13(2):310-5.
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  186. Feldman CL, Hubelbank M, Polan BA, Shook TA, Stone PH, and the ASIS Study Group. Sympathetic and parasympathetic influences overlap in the RR interval spectrum. J Ambulatory Monitoring. 1993; 6:259-262.
  187. Feldman CL, Fernandes JS, Stone PH. Flow imaging of 3-dimensional coronary artery models using computational fluid dynamics - Effect of coronary artery curvature. IEEE Proceedings of Computers in Cardiology. 1993; 1993:775-777.
  188. Feldman CL, Hubelbank M, Polan BA, Shook TA, Stone PH, and the ASIS Study Group. Sympathetic and parasympathetic influences overlap in the RR interval spectrum. J Ambulatory Monitoring. 1993; 6:259-262.
  189. Gibson CM, Diaz L, Kandarpa K, Sacks FM, Pasternak RC, Sandor T, Feldman C, Stone PH. The relationship of vessel wall shear stress to atherosclerosis progression in human coronary arteries. Arteriosclerosis and Thrombosis. 1993; 13:310-315.
  190. Detre KM, Stone PH. Co-Chairs. Working Group Report: Management of Coronary Heart Disease in Women. In Wanger NK, Speroff L, Packard B (eds.) . Cardiovascular Health and Disease in Women. Greenwich: LeJacq Communications. 1993; 99-101.
  191. Tofler GH, Muller JE, Stone PH, Forman S, Solomon RE, Knatterud GL, Braunwald E. Modifiers of timing and possible triggers of acute myocardial infarction in the Thrombolysis in Myocardial Infarction Phase II (TIMI II) Study Group. J Am Coll Cardiol. 1992 Nov 1; 20(5):1049-55.
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  192. Gibson CM, Sandor T, Stone PH, Pasternak RC, Rosner B, Sacks FM. Quantitative angiographic and statistical methods to assess serial changes in coronary luminal diameter and implications for atherosclerosis regression trials. Am J Cardiol. 1992 May 15; 69(16):1286-90.
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  193. The ACIP Investigators. Asymptomatic Cardiac Ischemia Pilot Study (ACIP). Am J Cardiol. 1992; 70:744-747.
  194. Brezinski D, Stone PH, Muller JE, Tofler GH, Davis V, Parker C, Hartley LH, Braunwald E. Prognostic significance of the Karnofsky Performance Status score in patients with acute myocardial infarction: comparison with the left ventricular ejection fraction and the exercise treadmill test performance. The MILIS Study Group. Am Heart J. 1991 May; 121(5):1374-81.
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  195. Feldman CL, Hubelbank M, Shook TL, Polan BA, MacCallum G, Stone PH, and the ASIS Study Group . Circadian variations in heart rate spectrum. IEEE Proceedings of Computers in Cardiology. 1991; 253-256.
  196. Brezinski DA, Stone PH. Effect of exercise training on cardiovascular physiology and the process of cardiac rehabilitation. Cardiovasc Rev and Rep. 1991; 13:34-47.
  197. Gibson CM, Stone PH. The effect of shear stress on the progression of human coronary atherosclerosis. Choices in Cardiology. 1991.
  198. Tofler GH, Chen X, Stone PH, Muller JE . Patient-identified potential triggers of myocardial infarction. Cardiology Board Review 1991. 1991.
  199. Andrews TC, Stone PH. Recent development in the understanding and management of "angina pectoris" in patients with stable coronary artery disease. Curr Opinion in Cardiol. 1991; 6:503-510.
  200. Stone PH. Pathophysiology of chronic stable angina:. Implications of the ASIS trial for selection of anti-ischemia medication. Choices in Cardiology. 1991; 5:212-215.
  201. Stone PH. The role of ST-segment monitoring in the management of patients with unstable angina. In: Rutherford JD ed. Unstable Angina Pectoris Management: A Practical Approach. 1991; 105-120.
  202. Stone PH, Gibson RS, Glasser SP, DeWood MA, Parker JD, Kawanishi DT, Crawford MH, Messineo FC, Shook TL, Raby K, et al. Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulatory ischemia in patients with stable angina. Differential effects on ambulatory ischemia, exercise performance, and anginal symptoms. The ASIS Study Group. Circulation. 1990 Dec; 82(6):1962-72.
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  203. Stone PH. Triggers of transient myocardial ischemia: circadian variation and relation to plaque rupture and coronary thrombosis in stable coronary artery disease. Am J Cardiol. 1990 Nov 6; 66(16):32G-36G.
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  204. Stone PH. Unraveling the mechanisms of ambulatory ischemia. How and why. Circulation. 1990 Oct; 82(4):1528-30.
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  205. Tofler GH, Stone PH, Maclure M, Edelman E, Davis VG, Robertson T, Antman EM, Muller JE. Analysis of possible triggers of acute myocardial infarction (the MILIS study). Am J Cardiol. 1990 Jul 1; 66(1):22-7.
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  206. Barzilai B, Davis VG, Stone PH, Jaffe AS. Prognostic significance of mitral regurgitation in acute myocardial infarction. The MILIS Study Group. Am J Cardiol. 1990 May 15; 65(18):1169-75.
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  207. Rice KR, Gervino E, Jarisch WR, Stone PH. Effects of nifedipine on myocardial perfusion during exercise in chronic stable angina pectoris. Am J Cardiol. 1990 May 1; 65(16):1097-101.
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  208. Stone PH . Triggers of transient myocardial ischemia:. Circadian variation and relationship to plaque rupture and coronary thrombosis in patients with stable coronary disease. 1990; 66:32G-36G.
  209. Stone PH. Mechanisms of silent myocardial ischemia: Implication for selection of optimal therapy. In: Kellermann JJ, Braunwald E (eds): Silent Myocardial Ischemia: A Critical Appraisal. Adv Cardiol. Basel, Karger . 1990; (37:328-348).
  210. Tofler GH, Stone PH, Maclure M, Edelman E, Davis VG, Robertson T, Antman EM, Muller JE, and the MILIS Study Group. Analysis of possible triggers of acute myocardial infarction (MILIS Study). Am J Cardiol 1990. 1990; 66:22-27.
  211. Rice KR, Gervino E, Jarisch WR, Stone PH. Enhanced myocardial perfusion during exercise by nifedipine in patients with chronic stable angina. Am J Cardiol. 1990; 65:1097-1101.
  212. Stone PH. Mechanisms of silent myocardial ischemia: implications for selection of optimal therapy. Adv Cardiol. 1990; 37:328-48.
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  213. Stone PH, Gibson RS, Glasser SP, DeWood MA, Parker JD, Kawanishi DT, Crawford MH, Messineo FC, Shook TL, Raby K, Curtis DG, Hoop RS, Young PM, Braunwald E and the ASIS Study Group. Comparison of propranolol, diltiazem, and nifedipine in the treatment of asymptomatic ischemia in patients with stable angina. Differential effects on asymptomatic ischemia, exercise performance, and anginal symptoms. Circulation. 1990; 82:1962-1972.
  214. Muller JE, Tofler GH, Willich SN, Aylmer G, Stone PH. Triggers of sudden cardiac death: The morning increase. In: Kostis JB, Sanders M (ed). Prevention of sudden cardiac death. Wiley-Liss New York. 1990; 21-41.
  215. Brezinski DA, Stone PH. Effect of exercise training on cardiovascular physiology and the process of cardiac rehabilitation . In: Kloner RA (ed): The Guide to Cardiology, Le Jacq Communications, New York . 1990; (35:505-515).
  216. Lockhart PB, Crist D, Stone PH. The reliability of the medical history in the identification of patients at risk for infective endocarditis. J Am Dent Assoc. 1989 Sep; 119(3):417-8, 421-2.
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  217. Tofler GH, Stone PH, Muller JE, Braunwald E. Mortality for women after acute myocardial infarction: MILIS Study Group. Am J Cardiol. 1989 Jul 15; 64(3):256.
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  218. Hands ME, Rutherford JD, Muller JE, Davies G, Stone PH, Parker C, Braunwald E. The in-hospital development of cardiogenic shock after myocardial infarction: incidence, predictors of occurrence, outcome and prognostic factors. The MILIS Study Group. J Am Coll Cardiol. 1989 Jul; 14(1):40-6; discussion 47-8.
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  219. Stone PH, Muller JE, Hartwell T, York BJ, Rutherford JD, Parker CB, Turi ZG, Strauss HW, Willerson JT, Robertson T, et al. The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis. The MILIS Study Group. J Am Coll Cardiol. 1989 Jul; 14(1):49-57.
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  220. Muller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation. 1989 Apr; 79(4):733-43.
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  221. Pohjola-Sintonen S, Muller JE, Stone PH, Willich SN, Antman EM, Davis VG, Parker CB, Braunwald E. Ventricular septal and free wall rupture complicating acute myocardial infarction: experience in the Multicenter Investigation of Limitation of Infarct Size. Am Heart J. 1989 Apr; 117(4):809-18.
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  222. Willich SN, Pohjola-Sintonen S, Bhatia SJ, Shook TL, Tofler GH, Muller JE, Curtis DG, Williams GH, Stone PH. Suppression of silent ischemia by metoprolol without alteration of morning increase of platelet aggregability in patients with stable coronary artery disease. Circulation. 1989 Mar; 79(3):557-65.
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  223. Tofler GH, Muller JE, Stone PH, Willich SN, Davis VG, Poole WK, Robertson T, Braunwald E. Pericarditis in acute myocardial infarction: characterization and clinical significance. Am Heart J. 1989 Jan; 117(1):86-92.
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  224. Lockhart PB, Crist D, Stone PH. The reliability of the medical history in the identification of patients with organic heart disease at risk for infective endocarditis following invasive dental procedures. J Am Dental Assoc. 1989; 119:417-422.
  225. Muller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute myocardial infarction. Clinical Progress Series. 1989; 79:733-743.
  226. Stone PH. Identification of the optimal time for aortic valve replacement in patients with chronic aortic insufficiency . Choices in Cardiology . 1989; 3:124-7.
  227. Hands ME, Rutherford JD, Muller JE, Davies G, Stone PH, Parker C, Braunwald E. The in-hospital development of cardiogenic shock after myocardial infarction: incidence, predictors of occurrence, outcome, and prognostic factors. J Am Coll Cardiol . 1989; 14:40-46.
  228. Hands ME, Sia ST, Shook TL, Anderson K, Stone PH, Levy D, Castelli WP, Rutherford JD. Silent myocardial ischemia in asymptomatic survivors of unrecognized myocardial infarction and matched controls. Am Heart J. 1988 Dec; 116(6 Pt 1):1488-92.
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  229. Lee RT, Lee TH, Poole WK, Gustafson N, Stone PH, Jaffe AS, Muller JE, Sobel BE, Roberts R, Braunwald E. Rate of disappearance of creatine kinase-MB after acute myocardial infarction: clinical determinants of variability. Am Heart J. 1988 Dec; 116(6 Pt 1):1493-9.
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  230. Tofler GH, Muller JE, Stone PH, Willich SN, Davis VG, Poole WK, Braunwald E. Factors leading to shorter survival after acute myocardial infarction in patients ages 65 to 75 years compared with younger patients. Am J Cardiol. 1988 Nov 1; 62(13):860-7.
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  231. Stone PH, Ware JH, DeWood MA, Gore JM, Eich RH, Pietro DA, Parisi AF, Nesto RW, Boden WE, Sharma SC, et al. The efficacy of the addition of nifedipine in patients with mixed angina compared to patients with classic exertional angina: a multicenter, randomized, double-blind, placebo-controlled clinical trial. Am Heart J. 1988 Oct; 116(4):961-71.
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  232. Hands ME, Cook EF, Stone PH, Muller JE, Hartwell T, Sobel BE, Roberts R, Braunwald E, Rutherford JD. Electrocardiographic diagnosis of myocardial infarction in the presence of complete left bundle branch block. Am Heart J. 1988 Jul; 116(1 Pt 1):23-31.
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  233. Stone PH, Raabe DS, Jaffe AS, Gustafson N, Muller JE, Turi ZG, Rutherford JD, Poole WK, Passamani E, Willerson JT, et al. Prognostic significance of location and type of myocardial infarction: independent adverse outcome associated with anterior location. J Am Coll Cardiol. 1988 Mar; 11(3):453-63.
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  234. Muller JE, Rude RE, Braunwald E, Hartwell TD, Roberts R, Sobel BE, Ritter C, Parker CB, Jaffe AS, Stone PH, et al. Myocardial infarct extension: occurrence, outcome, and risk factors in the Multicenter Investigation of Limitation of Infarct Size. Ann Intern Med. 1988 Jan; 108(1):1-6.
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  235. Muller JE, Rude RE, Braunwald E, Hartwell TD, Roberts R, Sobel BE, Ritter C, Parker CB, Jaffe AS, Stone PH, Raabe DS, Willerson JT, Robertson T, and the MILIS Study Group. Myocardial infarct extension: incidence, outcome, and risk factors in the MILIS Study. Ann Int Med. 1988; 108:1-6.
  236. Willich SN, Tofler GH, Klangos I, Stone PH, Muller JE. Circadian variation in the frequency of sudden cardiac death . International Synopses . 1988; 8:51-52.
  237. Stone PH, Raabe DS, Jaffe AS, Gustafson N, Muller JE, Turi ZG, Rutherford JD, Poole WK, Passamani E, Willerson JT, Sobel BE, Robertson T, Braunwald E, for the MILIS Group. Prognostic significance of location and type of myocardial infarction: Independent adverse outcome associated with anterior location . J Am Coll Cardiol . 1988; 11:453-63.
  238. Roberts R, Braunwald E, Muller JE, Croft C, Gold HK, Hartwell TD, Jaffe AS, Mullin SM, Parker C, Passamani E, Poole WK, Robertson T, Raabe DS Jr, Rude RE, Stone PH, Turi ZG, Sobel BE, Willerson JT, and the MILIS Study Group. Effect of hyaluronidase on mortality and morbidity in patients with early peaking of plasma creatine-kinase MB and non-transmural ischemia: the MILIS study. Br Heart J. 1988; 60: 290-298.
  239. Tofler GH, Stone PH. Circadian variation of silent ischemia: mechanism and potential significance . Cardiovasc Rev and Rep . 1988; (June Suppl):19-22.
  240. Muller JE, Stone PH, Rocco MB, Selwyn AP. Concurrent morning increase in silent ischemia, myocardial infarction, and sudden cardiac death. 1988; 2:9-12.
  241. Willich SN, Stone PH, Muller JE, Tofler GH, Crowder J, Parker C, Rutherford JD, Turi ZG, Robertson T, Passamani E, et al. High-risk subgroups of patients with non-Q wave myocardial infarction based on direction and severity of ST segment deviation. Am Heart J. 1987 Nov; 114(5):1110-9.
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  242. Cox DA, Stone PH, Muller JE, Parker C, Hartwell TD, Rutherford JD, Roberts R, Jaffe AS, Hackel DB, Passamani ER, et al. Prognostic implications of an early peak in plasma MB creatine kinase in patients with acute myocardial infarction. J Am Coll Cardiol. 1987 Nov; 10(5):979-90.
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  243. Willich SN, Levy D, Rocco MB, Tofler GH, Stone PH, Muller JE. Circadian variation in the incidence of sudden cardiac death in the Framingham Heart Study population. Am J Cardiol. 1987 Oct 1; 60(10):801-6.
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  244. Tofler GH, Stone PH, Muller JE, Rutherford JD, Willich SN, Gustafson NF, Poole WK, Sobel BE, Willerson JT, Robertson T, et al. Prognosis after cardiac arrest due to ventricular tachycardia or ventricular fibrillation associated with acute myocardial infarction (the MILIS Study). Multicenter Investigation of the Limitation of Infarct Size. Am J Cardiol. 1987 Oct 1; 60(10):755-61.
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  245. Shook TL, Balke CW, Kotilainen PW, Hubelbank M, Selwyn AP, Stone PH. Comparison of amplitude-modulated (direct) and frequency-modulated ambulatory techniques for recording ischemic electrocardiographic changes. Am J Cardiol. 1987 Oct 1; 60(10):895-900.
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  246. Tofler GH, Stone PH, Muller JE, Willich SN, Davis VG, Poole WK, Strauss HW, Willerson JT, Jaffe AS, Robertson T, et al. Effects of gender and race on prognosis after myocardial infarction: adverse prognosis for women, particularly black women. J Am Coll Cardiol. 1987 Mar; 9(3):473-82.
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  247. Willich SN, Stone PH, and the MILIS Study Group . Prognostic importance of the six-month post-infarction exercise test. Cardiology Board Review . 1987; 4:21-31.
  248. Stone PH. Calcium antagonists for Prinzmetal's variant angina, unstable angina, and silent myocardial ischemia: Therapeutic tool and probe for identification of pathophysiologic mechanisms. 1987; 59:101B-115B.
  249. Muller JE, Ludmer PL, Willich SN, Tofler GH, Aylmer G, Klangos I, Stone PH. Circadian variation in the frequency of sudden cardiac death. Circulation. 1987 Jan; 75(1):131-8.
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  250. Muller JE, Tofler GH, Willich SN, Stone PH. Circadian variation of cardiovascular disease and sympathetic activity. J Cardiovasc Pharmacol. 1987; 10 Suppl 2:S104-9; discussion S110-1.
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  251. Stone PH . Should we search for silent ischemia? A note of caution . Choices in Cardiology . 1987; (1:13-15).
  252. Shook TL, Valvo V, Hubelbank M, Feldman CL, Stone PH. Validation of a new algorithm for detection and quantification of ischemic ST segment changes during ambulatory electrocardiography. IEEE Proceedings Comput Cardiol. 1987; 57-62.
  253. Stone PH, Sacks FM, Smith TW. Use of hypolipidemic strategies to halt atherosclerosis: Evidence for alteration in clinical course. In: Grundy SM, Bearn AG, eds. The Role of Cholesterol in Atherosclerosis: New Therapeutic Opportunities. Philadelphia: Hanley and Belfus, Inc. 1987; (83-103).
  254. Stone PH. Calcium antagonists for Prinzmetal's variant angina, unstable angina, and silent myocardial ischemia: Therapeutic tool and probe for identification of pathophysiologic mechanisms. 1987; 59:101B-115B.
  255. Willich SN, Tofler GH, Klangos I, Stone PH, Muller JE . Time of day of sudden cardiac death. Cardiology Board Review. 1987; 4:47-54.
  256. Tofler G, Stone PH, Muller JE, Braunwald E . Clinical manifestations of coronary heart disease in women. In: Eaker ED, Packard B, Wenger NK, Clarkson TB, Tyroler HA, eds. Coronary Heart Disease in Women. New York: Haymarket Doyma Inc. 1987; (215-221).
  257. Stone PH, Turi ZG, Muller JE, Parker C, Hartwell T, Rutherford JD, Jaffe AS, Raabe DS, Passamani ER, Willerson JT, et al. Prognostic significance of the treadmill exercise test performance 6 months after myocardial infarction. J Am Coll Cardiol. 1986 Nov; 8(5):1007-17.
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  258. Turi ZG, Stone PH, Muller JE, Parker C, Rude RE, Raabe DE, Jaffe AS, Hartwell TD, Robertson TL, Braunwald E. Implications for acute intervention related to time of hospital arrival in acute myocardial infarction. Am J Cardiol. 1986 Aug 1; 58(3):203-9.
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  259. Lamas GA, Muller JE, Turi ZG, Stone PH, Rutherford JD, Jaffe AS, Raabe DS, Rude RE, Mark DB, Califf RM, et al. A simplified method to predict occurrence of complete heart block during acute myocardial infarction. Am J Cardiol. 1986 Jun 1; 57(15):1213-9.
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  260. Croft CH, Rude RE, Gustafson N, Stone PH, Poole WK, Roberts R, Strauss HW, Raabe DS, Thomas LJ, Jaffe AS, et al. Abrupt withdrawal of beta-blockade therapy in patients with myocardial infarction: effects on infarct size, left ventricular function, and hospital course. Circulation. 1986 Jun; 73(6):1281-90.
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  261. Muller JE, Turi ZG, Stone PH, Rude RE, Raabe DS, Jaffe AS, Gold HK, Gustafson N, Poole WK, Passamani E, Smith TW, Braunwald E, and the MILIS Study Group. Digoxin therapy and mortality after myocardial infarction: Experience in the MILIS Study. New Engl J Med. 1986; 314:265-271.
  262. MILIS Study Group. Hyaluronidase therapy for acute myocardial infarction: results of a randomized, blinded, multi-center trial. Am J Cardiol. 1986; 57:1236-1243.
  263. Willich SN, Czeisler CA, Tofler GH, Ludmer P, Aylmer G, Rutherford JD, Stone PH, Muller JE. Circadian variation in the frequency of occurrence of acute cardiovascular disease. In: Reinberg A, Smolensky M, Labrecque G, eds. Annual Review of Chronopharmacology, Volume 3. Oxford: Pergamon Press, Ltd . 1986; (3:327-330).
  264. Tofler GH, Stone PH. Clinical patterns of angina pectoris. How pathophysiology determines therapy. 1986; 80:148-166.
  265. Stone PH . Calcium channel blocking agents in the treatment of angina pectoris. In: Kostis JB, Defelice EA, eds. Pharmacological Treatment of Cardiovascular Diseases. New York: Medical Examination Publishing Company . 1986; 132-154.
  266. Turi ZG, Rutherford JD, Roberts R, Muller JE, Jaffe AS, Rude RE, Parker C, Raabe DS, Stone PH, Hartwell TD, et al. Electrocardiographic, enzymatic and scintigraphic criteria of acute myocardial infarction as determined from study of 726 patients (A MILIS Study). Am J Cardiol. 1985 Jun 1; 55(13 Pt 1):1463-8.
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  267. Stone PH, Rude RE, Muller JE, Braunwald E . Current status of interventions designed to limit infarct size. In: Levine HJ, Gaasch WH, eds. The Ventricle. Boston: Martinus Nijhoff. 1985; 289-314.
  268. Given BD, Lee TH, Stone PH, Dzau VJ . Use of nifedipine in severely hypertensive patients with congestive heart failure and preserved left ventricular systolic function. Arch Intern Med . 1985; 145:281-285..
  269. Muller JE, Stone PH, Turi ZG, Pearle DL, Schneider JF, Serfas DH, Morrison J, Rude RE, Rosner B, Sobel BE, Tate C, Scheiner E, Roberts R, Hennekens CH, Braunwald E. Nifedipine versus conventional therapy for unstable angina pectoris: A randomized, double-blind comparison. In: Lichtlen PR, ed. Recent Aspects in Calcium Antagonism. New York: Schattauer. 1985; 101-127.
  270. Braunwald E, Muller JE, Stone PH. Use of calcium channel blocking agents in the management of ischaemic heart disease. Eur Heart J. 1985 Jan; 6 Suppl A:31-6.
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  271. Lee TH, Friedman PL, Goldman L, Stone PH, Antman EM. Sinus arrest and hypotension with combined amiodarone-diltiazem therapy. Am Heart J. 1985 Jan; 109(1):163-4.
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  272. Stone PH, Braunwald E. Calcium channel blocking agents. In: Braunwald E, ed. Harrison's Principles of Internal Medicine . Updates of Internal Medicine VI. New York: McGraw-Hill. 1985; 109-131.
  273. Muller JE, Stone PH, Turi ZG, Rutherford JD, Czeisler C, Parker C, Poole WK, Passamani E, Roberts R, Robertson T, Sobel BE, Willerson JT, Braunwald E, and the MILIS Study Group Circadian variation in the onset of acute myocardial infarction. New Engl J Med 1985;313: 1315-1322. Circadian variation in the onset of acute myocardial infarction. New Engl J Med. 1985; 313: 1315-1322.
  274. Muller JE, Turi ZG, Pearle DL, Schneider JF, Serfas DH, Morrison J, Stone PH, Rude RE, Rosner B, Sobel BE, et al. Nifedipine and conventional therapy for unstable angina pectoris: a randomized, double-blind comparison. Circulation. 1984 Apr; 69(4):728-39.
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  275. Muller JE, Morrison J, Stone PH, Rude RE, Rosner B, Roberts R, Pearle DL, Turi ZG, Schneider JF, Serfas DH, et al. Nifedipine therapy for patients with threatened and acute myocardial infarction: a randomized, double-blind, placebo-controlled comparison. Circulation. 1984 Apr; 69(4):740-7.
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  276. Stone PH, Clark RD, Goldschlager N, Selzer A, Cohn K. Determinants of prognosis of patients with aortic insufficiency with undergo aortic valve replacement. J Am Coll Cardiol. 1984; 3:1118-1126.
  277. Croft CH, Rude RE, Lewis SE, Parkey RW, Poole WK, Parker C, Fox N, Roberts R, Strauss HW, Thomas LC Jr, Raabe DS Jr, Sobel BE, Gold HK, Stone PH, Braunwald E, Willerson JT, and the MILIS Study Group. Comparison of left ventricular function and infarct size in patients with and without persistently positive technetium-99m pyrophosphate myocardial scintigrams after myocardial infarction: Analysis of 357 patients. Am J Cardiol. 1984; 53:421-428.
  278. Stone PH. Effects of exercise on cardiovascular physiology and cardiac rehabilitation. In: Kloner RA, ed. The Guide to Cardiology. New York: John Wiley & Sons. 1984; 577-590.
  279. Roberts R, Croft C, Gold HK, Hartwell TD, Jaffe AS, Muller JE, Mullin SM, Parker C, Passamani ER, Poole WK, Raabe DS, Rude RE, Stone PH, Turi ZG, Sobel BE, Willerson JT, Braunwald E, and the MILIS Study Group. Effect of propranolol on myocardial infarct size in a randomized, blinded, multi-center trial. New Engl J Med. 1984; 311:218-225.
  280. Kirshenbaum J, Stone PH. The non-invasive detection of left main coronary artery disease. Primary Cardiology. 1984; 10:87-101.
  281. Hackel DB, Reimer KA, Ideker RE, Mikat EM, Hartwell TD, Parker CB, Braunwald E, Gold HK, Raabe DS, Rude RE, Sobel BE, Stone PH, Buja M, Muller JE, Roberts R, and the MILIS Study Group . Comparison of enzymatic and anatomic estimates of myocardial infarct size in man 1984;70:824-835. . Circulation. 1984; 70:824-835.
  282. Stone PH, Muller JE, Turi ZG, Geltman E, Jaffe AS, Braunwald E. Efficacy of nifedipine therapy in patients with refractory angina pectoris: significance of the presence of coronary vasospasm. Arq Bras Cardiol. 1983 Dec; 41(6):469-76.
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  283. Rude RE, Poole WK, Muller JE, Turi Z, Rutherford J, Parker C, Roberts R, Raabe DS, Gold HK, Stone PH, et al. Electrocardiographic and clinical criteria for recognition of acute myocardial infarction based on analysis of 3,697 patients. Am J Cardiol. 1983 Nov 1; 52(8):936-42.
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  284. Stone PH, Muller JE, Turi ZG, Geltman E, Jaffe AS, Braunwald E. Efficacy of nifedipine therapy in patients with refractory angina pectoris: significance of the presence of coronary vasospasm. Am Heart J. 1983 Oct; 106(4 Pt 1):644-52.
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  285. Stone PH, Antman EM, Muller JE. Nifedipine therapy for coronary vasospasm. Arch Mal Coeur Vaiss. 1983 Feb; 76 Spec No:137-42.
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  286. Stone PH. Use of nifedipine therapy for patients with refractory angina pectoris. Practical Cardiology. 1983; 18-29.
  287. Stone PH, Antman EM, eds. Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. 1983.
  288. Antman EM, Horowitz J, Stone PH. Clinical pharmacology of the calcium channel blocking agents. In: Stone PH, Antman EM, eds. Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. 1983; 177-202..
  289. Stone PH. Exercise testing in perspective. Primary Cardiology . 1983; 9:111-138.
  290. Stone PH . Use of the calcium channel blocking agents to salvage ischemic myocardium. In: Calcium Antagonists: The State of the Art and Role in Cardiovascular Disease. The American College of Clinical Pharmacology. 1983; 2:209-223.
  291. Stone PH, Antman EM. Use of calcium channel blocking agents in unstable angina and acute myocardial infarction. In: Stone PH, Antman EM, eds Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. New York: Futura Publishing Company. 1983; 321-346.
  292. Muller JE, Stone PH . Post-MI angina: pointers for proper therapy . Illustrated Medicine. 1983; 2:1-8.
  293. Stone PH. Medical Emergencies: Chest pain. Audio-Digest. Family Practice. 1983; 31.
  294. Stone PH, Turi ZG, Muller JE. Efficacy of nifedipine therapy for refractory angina pectoris. Am Heart J. 1982 Sep; 104(3):672-81.
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  295. Goldman L, Cook F, Hashimotso B, Stone P, Muller J, Loscalzo A. Evidence that hospital care for acute myocardial infarction has not contributed to the decline in coronary mortality between 1973-1974 and 1978-1979. Circulation. 1982 May; 65(5):936-42.
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  296. Braunwald E, Stone PH. Does coronary artery bypass grafting improve survival? West J Med. 1982 Apr; 136(4):339-41.
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  297. Stone PH, Muller JE. Nifedipine therapy for recurrent ischemic pain following myocardial infarction. Clin Cardiol. 1982 Mar; 5(3):223-30.
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  298. Stone PH. Use of calcium channel blocking agents in the treatment of chronic stable angina pectoris. Cardiovascular Review and Reports. 1982; 3:39-53.
  299. Braunwald E, Stone PH . Does coronary artery surgery improve survival? 1982. 1982; 136:339-341.
  300. Stone PH, LaFollette E, Cohn K. Patterns of exercise treadmill test performance in patients with left main coronary disease. Am Heart J. 1982; 104:13-19.
  301. Stone PH, Cohn PF. Exercise testing. In: Cohn PF, Wynne J, eds. Cardiac Diagnostic Procedures for the Clinician. 1982; 51-79.
  302. Stone PH. Drug therapy: The promise of nifedipine . 1982; 7:181-196.
  303. Stone PH, Sherrid MV, Cohn KE. Correlation of HLA types in premature coronary artery disease: an attempt to define independent genetic risk factors. Chest. 1981 Apr; 79(4):381-5.
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  304. Muller JE, Stone PH, Markis JE, Braunwald E. Let's not let the Genie escape from the bottle again. New Engl J Med. 1981; (304:1294-6).
  305. Stone PH . Exercise testing in perspective. Cardiac Rehabilitation Quarterly. 1980; 11:1-8.
  306. Stone PH, Antman EM, Muller JE, Braunwald E. Calcium channel blocking agents in the treatment of cardiovascular disorders. II: Hemodynamic effects and clinical application. 1980; 93:886-904.
  307. Antman EM, Stone PH, Muller JE, Braunwald E . Calcium channel blocking agents in the treatment of cardiovascular disorders. Basic and clinical electrophysiologic effects. 1980; 93:875-885.
  308. Stone PH, Goldschlager N. Left main coronary artery disease: Review and appraisal. Cardiovasc Med. 1979; 4:165 182.
  309. Moore A, Gottfried EL, Stone PH, Coleman M. Case report. Clostridium perfringens septicemia with detection of phospholipase C activity in the serum. Am J Med Sci. 1976 Jan-Feb; 271(1):59-63.
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