Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Xihong Lin, Ph.D.

TitleProfessor of Biostatistics
InstitutionHarvard School of Public Health
DepartmentBiostatistics
AddressHarvard School of Public Health
Biostatistics, Bldg 2-451
655 Huntington Ave
Boston MA 02115
Phone617/432-2914

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Lin Laboratory - Software (6)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Wang X, Lee S, Zhu X, Redline S, Lin X. GEE-Based SNP Set Association Test for Continuous and Discrete Traits in Family-Based Association Studies. Genet Epidemiol. 2013 Dec; 37(8):778-86.
    View in: PubMed
  2. Qian ZR, Ter-Minassian M, Chan JA, Imamura Y, Hooshmand SM, Kuchiba A, Morikawa T, Brais LK, Daskalova A, Heafield R, Lin X, Christiani DC, Fuchs CS, Ogino S, Kulke MH. Prognostic Significance of MTOR Pathway Component Expression in Neuroendocrine Tumors. J Clin Oncol. 2013 Sep 20; 31(27):3418-25.
    View in: PubMed
  3. Pan WC, Kile ML, Seow WJ, Lin X, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DC. Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes. PLoS One. 2013; 8(8):e70792.
    View in: PubMed
  4. Huang YT, Lin X. Gene set analysis using variance component tests. BMC Bioinformatics. 2013; 14:210.
    View in: PubMed
  5. Lee S, Teslovich TM, Boehnke M, Lin X. General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies. Am J Hum Genet. 2013 Jul 11; 93(1):42-53.
    View in: PubMed
  6. Li L, Kabesch M, Bouzigon E, Demenais F, Farrall M, Moffatt MF, Lin X, Liang L. Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma. Front Genet. 2013; 4:103.
    View in: PubMed
  7. Hu T, Lin X, Nan B. Cross-ratio estimation for bivariate failure times with left truncation. Lifetime Data Anal. 2014 Jan; 20(1):23-37.
    View in: PubMed
  8. Sofer T, Baccarelli A, Cantone L, Coull B, Maity A, Lin X, Schwartz J. Exposure to airborne particulate matter is associated with methylation pattern in the asthma pathway. Epigenomics. 2013 Apr; 5(2):147-54.
    View in: PubMed
  9. Ter-Minassian M, Chan JA, Hooshmand SM, Brais LK, Daskalova A, Heafield R, Buchanan L, Qian ZR, Fuchs CS, Lin X, Christiani DC, Kulke MH. Clinical presentation, recurrence, and survival in patients with neuroendocrine tumors: results from a prospective institutional database. Endocr Relat Cancer. 2013; 20(2):187-96.
    View in: PubMed
  10. Lin X, Lee S, Christiani DC, Lin X. Test for interactions between a genetic marker set and environment in generalized linear models. Biostatistics. 2013 Sep; 14(4):667-81.
    View in: PubMed
  11. Liu CY, Maity A, Lin X, Wright RO, Christiani DC. Design and analysis issues in gene and environment studies. Environ Health. 2012; 11:93.
    View in: PubMed
  12. Barnett IJ, Lee S, Lin X. Detecting rare variant effects using extreme phenotype sampling in sequencing association studies. Genet Epidemiol. 2013 Feb; 37(2):142-51.
    View in: PubMed
  13. Zhao Y, Chen F, Zhai R, Lin X, Wang Z, Su L, Christiani DC. Correction for population stratification in random forest analysis. Int J Epidemiol. 2012 Dec; 41(6):1798-806.
    View in: PubMed
  14. Seow WJ, Pan WC, Kile ML, Baccarelli AA, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lin X, Christiani DC. Arsenic reduction in drinking water and improvement in skin lesions: a follow-up study in bangladesh. Environ Health Perspect. 2012 Dec; 120(12):1733-8.
    View in: PubMed
  15. Zhao Y, Chen F, Zhai R, Lin X, Diao N, Christiani DC. Association test based on SNP set: logistic kernel machine based test vs. principal component analysis. PLoS One. 2012; 7(9):e44978.
    View in: PubMed
  16. Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA, Christiani DC, Wurfel MM, Lin X. Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet. 2012 Aug 10; 91(2):224-37.
    View in: PubMed
  17. Cai T, Lin X, Carroll RJ. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics. 2012 Sep; 13(4):776-90.
    View in: PubMed
  18. Lee S, Wu MC, Lin X. Optimal tests for rare variant effects in sequencing association studies. Biostatistics. 2012 Sep; 13(4):762-75.
    View in: PubMed
  19. Choi H, Wang L, Lin X, Spengler JD, Perera FP. Fetal window of vulnerability to airborne polycyclic aromatic hydrocarbons on proportional intrauterine growth restriction. PLoS One. 2012; 7(4):e35464.
    View in: PubMed
  20. VanderWeele TJ, Asomaning K, Tchetgen Tchetgen EJ, Han Y, Spitz MR, Shete S, Wu X, Gaborieau V, Wang Y, McLaughlin J, Hung RJ, Brennan P, Amos CI, Christiani DC, Lin X. Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. Am J Epidemiol. 2012 May 15; 175(10):1013-20.
    View in: PubMed
  21. Yu Z, Lin X, Tu W. Semiparametric frailty models for clustered failure time data. Biometrics. 2012 Jun; 68(2):429-36.
    View in: PubMed
  22. Huang YT, Lin X, Liu Y, Chirieac LR, McGovern R, Wain J, Heist R, Skaug V, Zienolddiny S, Haugen A, Su L, Fox EA, Wong KK, Christiani DC. Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16345-50.
    View in: PubMed
  23. Lin X, Cai T, Wu MC, Zhou Q, Liu G, Christiani DC, Lin X. Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies. Genet Epidemiol. 2011 Nov; 35(7):620-31.
    View in: PubMed
  24. Ter-Minassian M, Asomaning K, Zhao Y, Chen F, Su L, Carmella SG, Lin X, Hecht SS, Christiani DC. Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). Int J Cancer. 2012 Mar 15; 130(6):1338-46.
    View in: PubMed
  25. Huang YT, Lin X, Chirieac LR, McGovern R, Wain JC, Heist RS, Skaug V, Zienolddiny S, Haugen A, Su L, Christiani DC. Impact on disease development, genomic location and biological function of copy number alterations in non-small cell lung cancer. PLoS One. 2011; 6(8):e22961.
    View in: PubMed
  26. Zhai R, Zhao Y, Liu G, Ter-Minassian M, Wu IC, Wang Z, Su L, Asomaning K, Chen F, Kulke MH, Lin X, Heist RS, Wain JC, Christiani DC. Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study. Cancer. 2012 Feb 1; 118(3):804-11.
    View in: PubMed
  27. Ter-Minassian M, Wang Z, Asomaning K, Wu MC, Liu CY, Paulus JK, Liu G, Bradbury PA, Zhai R, Su L, Frauenhoffer CS, Hooshmand SM, De Vivo I, Lin X, Christiani DC, Kulke MH. Genetic associations with sporadic neuroendocrine tumor risk. Carcinogenesis. 2011 Aug; 32(8):1216-22.
    View in: PubMed
  28. Fu S, Yang L, Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GS. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature. 2011 May 26; 473(7348):528-31.
    View in: PubMed
  29. Laohaudomchok W, Lin X, Herrick RF, Fang SC, Cavallari JM, Christiani DC, Weisskopf MG. Toenail, blood, and urine as biomarkers of manganese exposure. J Occup Environ Med. 2011 May; 53(5):506-10.
    View in: PubMed
  30. Cai T, Tonini G, Lin X. Kernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics. 2011 Sep; 67(3):975-86.
    View in: PubMed
  31. Laohaudomchok W, Lin X, Herrick RF, Fang SC, Cavallari JM, Shrairman R, Landau A, Christiani DC, Weisskopf MG. Neuropsychological effects of low-level manganese exposure in welders. Neurotoxicology. 2011 Mar; 32(2):171-9.
    View in: PubMed
  32. Dicker L, Lin X, Ivanov AR. Increased power for the analysis of label-free LC-MS/MS proteomics data by combining spectral counts and peptide peak attributes. Mol Cell Proteomics. 2010 Dec; 9(12):2704-18.
    View in: PubMed
  33. Laohaudomchok W, Cavallari JM, Fang SC, Lin X, Herrick RF, Christiani DC, Weisskopf MG. Assessment of occupational exposure to manganese and other metals in welding fumes by portable X-ray fluorescence spectrometer. J Occup Environ Hyg. 2010 Aug; 7(8):456-65.
    View in: PubMed
  34. Paulus JK, Zhou W, Kraft P, Johnson BE, Lin X, Christiani DC. Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women. Lung Cancer. 2011 Mar; 71(3):258-63.
    View in: PubMed
  35. Naylor MG, Lin X, Weiss ST, Raby BA, Lange C. Using canonical correlation analysis to discover genetic regulatory variants. PLoS One. 2010; 5(5):e10395.
    View in: PubMed
  36. Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. A Large-scale genetic association study of esophageal adenocarcinoma risk. Carcinogenesis. 2010 Jul; 31(7):1259-63.
    View in: PubMed
  37. Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC. Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol. 2010 May 10; 28(14):2445-51.
    View in: PubMed
  38. Paulus JK, Asomaning K, Kraft P, Johnson BE, Lin X, Christiani DC. Parity and risk of lung cancer in women. Am J Epidemiol. 2010 Mar 1; 171(5):557-63.
    View in: PubMed
  39. Wu MC, Lin X. Prior biological knowledge-based approaches for the analysis of genome-wide expression profiles using gene sets and pathways. Stat Methods Med Res. 2009 Dec; 18(6):577-93.
    View in: PubMed
  40. Huang YT, Heist RS, Chirieac LR, Lin X, Skaug V, Zienolddiny S, Haugen A, Wu MC, Wang Z, Su L, Asomaning K, Christiani DC. Genome-wide analysis of survival in early-stage non-small-cell lung cancer. J Clin Oncol. 2009 Jun 1; 27(16):2660-7.
    View in: PubMed
  41. Wang Z, Chen F, Zhai R, Zhang L, Su L, Lin X, Thompson T, Christiani DC. Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development. PLoS One. 2009; 4(2):e4380.
    View in: PubMed
  42. Wu MC, Zhang L, Wang Z, Christiani DC, Lin X. Sparse linear discriminant analysis for simultaneous testing for the significance of a gene set/pathway and gene selection. Bioinformatics. 2009 May 1; 25(9):1145-51.
    View in: PubMed
  43. Zhai R, Liu G, Asomaning K, Su L, Kulke MH, Heist RS, Nishioka NS, Lynch TJ, Wain JC, Lin X, Christiani DC. Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk. Carcinogenesis. 2008 Dec; 29(12):2330-4.
    View in: PubMed
  44. Ter-Minassian M, Zhai R, Asomaning K, Su L, Zhou W, Liu G, Heist RS, Lynch TJ, Wain JC, Lin X, De Vivo I, Christiani DC. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis. 2008 Nov; 29(11):2147-52.
    View in: PubMed
  45. Liu D, Ghosh D, Lin X. Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models. BMC Bioinformatics. 2008; 9:292.
    View in: PubMed
  46. Nan B, Lin X. Analysis of case-control age-at-onset data using a modified case-cohort method. Biom J. 2008 Apr; 50(2):311-20.
    View in: PubMed
  47. Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol. 2008 Feb 20; 26(6):856-62.
    View in: PubMed
  48. Lin X. Estimation using penalized quasilikelihood and quasi-pseudo-likelihood in Poisson mixed models. Lifetime Data Anal. 2007 Dec; 13(4):533-44.
    View in: PubMed
  49. Harezlak J, Wang M, Christiani D, Lin X. Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments. Bioinformatics. 2007 Sep 15; 23(18):2441-8.
    View in: PubMed
  50. Su L, Zhou W, Asomaning K, Lin X, Wain JC, Lynch TJ, Liu G, Christiani DC. Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer. Carcinogenesis. 2006 May; 27(5):1024-9.
    View in: PubMed
  51. Li Y, Lin X. Testing the correlation for clustered categorical and censored discrete time-to-event data when covariates are measured without/with errors. Biometrics. 2003 Mar; 59(1):25-35.
    View in: PubMed
  52. Zhang D, Lin X. Hypothesis testing in semiparametric additive mixed models. Biostatistics. 2003 Jan; 4(1):57-74.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: SPH faculty should contact Justin Sayde (jsaydehsph.harvard.edu).
Lin's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department