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Tianxi Cai, Sc.D.

TitleProfessor of Biostatistics
InstitutionHarvard School of Public Health
DepartmentBiostatistics
AddressHarvard School of Public Health
Bldg 1, RM 411
655 Huntington Ave
Boston MA 02115
Phone617/432-4923

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Liao KP, Kurreeman F, Li G, Duclos G, Murphy S, Guzman R, Cai T, Gupta N, Gainer V, Schur P, Cui J, Denny JC, Szolovits P, Churchill S, Kohane I, Karlson EW, Plenge RM. Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls. Arthritis Rheum. 2013 Mar; 65(3):571-81.
    View in: PubMed
  2. Ananthakrishnan AN, Gainer VS, Cai T, Perez RG, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw S, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis. Am J Gastroenterol. 2013 Apr; 108(4):594-601.
    View in: PubMed
  3. Ananthakrishnan AN, Gainer VS, Perez RG, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease. Aliment Pharmacol Ther. 2013 Feb; 37(4):445-54.
    View in: PubMed
  4. Liu D, Cai T, Zheng Y. Evaluating the predictive value of biomarkers with stratified case-cohort design. Biometrics. 2012 Dec; 68(4):1219-27.
    View in: PubMed
  5. Cai T, Lin X, Carroll RJ. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics. 2012 Sep; 13(4):776-90.
    View in: PubMed
  6. Lu MT, Demehri S, Cai T, Parast L, Hunsaker AR, Goldhaber SZ, Rybicki FJ. Axial and reformatted four-chamber right ventricle-to-left ventricle diameter ratios on pulmonary CT angiography as predictors of death after acute pulmonary embolism. AJR Am J Roentgenol. 2012 Jun; 198(6):1353-60.
    View in: PubMed
  7. Carroll RJ, Thompson WK, Eyler AE, Mandelin AM, Cai T, Zink RM, Pacheco JA, Boomershine CS, Lasko TA, Xu H, Karlson EW, Perez RG, Gainer VS, Murphy SN, Ruderman EM, Pope RM, Plenge RM, Kho AN, Liao KP, Denny JC. Portability of an algorithm to identify rheumatoid arthritis in electronic health records. J Am Med Inform Assoc. 2012 Jun; 19(1e):e162-9.
    View in: PubMed
  8. Ananthakrishnan AN, Guzman-Perez R, Gainer V, Cai T, Churchill S, Kohane I, Plenge RM, Murphy S. Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2012 Apr; 35(7):789-95.
    View in: PubMed
  9. Tian L, Cai T, Zhao L, Wei LJ. On the covariate-adjusted estimation for an overall treatment difference with data from a randomized comparative clinical trial. Biostatistics. 2012 Apr; 13(2):256-73.
    View in: PubMed
  10. Qi L, Parast L, Cai T, Powers C, Gervino EV, Hauser TH, Hu FB, Doria A. Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies. J Am Coll Cardiol. 2011 Dec 13; 58(25):2675-82.
    View in: PubMed
  11. Zheng Y, Cai T, Jin Y, Feng Z. Evaluating prognostic accuracy of biomarkers under competing risk. Biometrics. 2012 Jun; 68(2):388-96.
    View in: PubMed
  12. Cai T, Zheng Y. Evaluating prognostic accuracy of biomarkers in nested case-control studies. Biostatistics. 2012 Jan; 13(1):89-100.
    View in: PubMed
  13. Lin X, Cai T, Wu MC, Zhou Q, Liu G, Christiani DC, Lin X. Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies. Genet Epidemiol. 2011 Nov; 35(7):620-31.
    View in: PubMed
  14. Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin X. Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet. 2011 Jul 15; 89(1):82-93.
    View in: PubMed
  15. Perlis RH, Iosifescu DV, Castro VM, Murphy SN, Gainer VS, Minnier J, Cai T, Goryachev S, Zeng Q, Gallagher PJ, Fava M, Weilburg JB, Churchill SE, Kohane IS, Smoller JW. Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model. Psychol Med. 2012 Jan; 42(1):41-50.
    View in: PubMed
  16. Uno H, Cai T, Tian L, Wei LJ. Graphical procedures for evaluating overall and subject-specific incremental values from new predictors with censored event time data. Biometrics. 2011 Dec; 67(4):1389-96.
    View in: PubMed
  17. Cai T, Tian L, Lloyd-Jones DM. Comparing costs associated with risk stratification rules for t-year survival. Biostatistics. 2011 Oct; 12(4):597-609.
    View in: PubMed
  18. Parast L, Cheng SC, Cai T. Incorporating short-term outcome information to predict long-term survival with discrete markers. Biom J. 2011 Mar; 53(2):294-307.
    View in: PubMed
  19. Cai T, Tonini G, Lin X. Kernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics. 2011 Sep; 67(3):975-86.
    View in: PubMed
  20. Uno H, Cai T, Pencina MJ, D'Agostino RB, Wei LJ. On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data. Stat Med. 2011 May 10; 30(10):1105-17.
    View in: PubMed
  21. Kurreeman F, Liao K, Chibnik L, Hickey B, Stahl E, Gainer V, Li G, Bry L, Mahan S, Ardlie K, Thomson B, Szolovits P, Churchill S, Murphy SN, Cai T, Raychaudhuri S, Kohane I, Karlson E, Plenge RM. Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am J Hum Genet. 2011 Jan 7; 88(1):57-69.
    View in: PubMed
  22. Cai T, Tian L, Wong PH, Wei LJ. Analysis of randomized comparative clinical trial data for personalized treatment selections. Biostatistics. 2011 Apr; 12(2):270-82.
    View in: PubMed
  23. Cai T, Parast L, Ryan L. Meta-analysis for rare events. Stat Med. 2010 Sep 10; 29(20):2078-89.
    View in: PubMed
  24. Tian L, Wang R, Cai T, Wei LJ. The highest confidence density region and its usage for joint inferences about constrained parameters. Biometrics. 2011 Jun; 67(2):604-10.
    View in: PubMed
  25. Love TJ, Cai T, Karlson EW. Validation of psoriatic arthritis diagnoses in electronic medical records using natural language processing. Semin Arthritis Rheum. 2011 Apr; 40(5):413-20.
    View in: PubMed
  26. Hunsaker AR, Oliva IB, Cai T, Trotman-Dickenson B, Gill RR, Hatabu H, Rybicki FJ. Contrast opacification using a reduced volume of iodinated contrast material and low peak kilovoltage in pulmonary CT angiography: Objective and subjective evaluation. AJR Am J Roentgenol. 2010 Aug; 195(2):W118-24.
    View in: PubMed
  27. Liao KP, Cai T, Gainer V, Goryachev S, Zeng-treitler Q, Raychaudhuri S, Szolovits P, Churchill S, Murphy S, Kohane I, Karlson EW, Plenge RM. Electronic medical records for discovery research in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010 Aug; 62(8):1120-7.
    View in: PubMed
  28. Cai T, Gerds TA, Zheng Y, Chen J. Robust prediction of t-year survival with data from multiple studies. Biometrics. 2011 Jun; 67(2):436-44.
    View in: PubMed
  29. Gao X, Lai CQ, Scott T, Shen J, Cai T, Ordovas JM, Tucker KL. Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults. Am J Epidemiol. 2010 Aug 1; 172(3):271-8.
    View in: PubMed
  30. Wu C, Sodickson A, Cai T, Levit NA, Steigner ML, Rybicki FJ, Ledbetter SM. Comparison of respiratory motion artifact from craniocaudal versus caudocranial scanning with 64-MDCT pulmonary angiography. AJR Am J Roentgenol. 2010 Jul; 195(1):155-9.
    View in: PubMed
  31. Rybicki FJ, Mitsouras D, Owens CD, Whitmore A, Gerhard-Herman M, Wake N, Cai T, Zhou Q, Conte MS, Creager MA, Mulkern RV. Multi-contrast high spatial resolution black blood inner volume three-dimensional fast spin echo MR imaging in peripheral vein bypass grafts. Int J Cardiovasc Imaging. 2010 Aug; 26(6):683-91.
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  32. Steigner ML, Mitsouras D, Whitmore AG, Otero HJ, Wang C, Buckley O, Levit NA, Hussain AZ, Cai T, Mather RT, Smedby O, DiCarli MF, Rybicki FJ. Iodinated contrast opacification gradients in normal coronary arteries imaged with prospectively ECG-gated single heart beat 320-detector row computed tomography. Circ Cardiovasc Imaging. 2010 Mar; 3(2):179-86.
    View in: PubMed
  33. Cai T, Huang J, Tian L. Regularized estimation for the accelerated failure time model. Biometrics. 2009 Jun; 65(2):394-404.
    View in: PubMed
  34. Cornelis MC, Qi L, Zhang C, Kraft P, Manson J, Cai T, Hunter DJ, Hu FB. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med. 2009 Apr 21; 150(8):541-50.
    View in: PubMed
  35. Zheng Y, Cai T, Stanford JL, Feng Z. Semiparametric models of time-dependent predictive values of prognostic biomarkers. Biometrics. 2010 Mar; 66(1):50-60.
    View in: PubMed
  36. Chien K, Cai T, Hsu H, Su T, Chang W, Chen M, Lee Y, Hu FB. A prediction model for type 2 diabetes risk among Chinese people. Diabetologia. 2009 Mar; 52(3):443-50.
    View in: PubMed
  37. Tian L, Cai T, Pfeffer MA, Piankov N, Cremieux PY, Wei LJ. Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction. Biostatistics. 2009 Apr; 10(2):275-81.
    View in: PubMed
  38. Gerds TA, Cai T, Schumacher M. The performance of risk prediction models. Biom J. 2008 Aug; 50(4):457-79.
    View in: PubMed
  39. Steigner ML, Otero HJ, Cai T, Mitsouras D, Nallamshetty L, Whitmore AG, Ersoy H, Levit NA, Di Carli MF, Rybicki FJ. Narrowing the phase window width in prospectively ECG-gated single heart beat 320-detector row coronary CT angiography. Int J Cardiovasc Imaging. 2009 Jan; 25(1):85-90.
    View in: PubMed
  40. Lu MT, Cai T, Ersoy H, Whitmore AG, Levit NA, Goldhaber SZ, Rybicki FJ. Comparison of ECG-gated versus non-gated CT ventricular measurements in thirty patients with acute pulmonary embolism. Int J Cardiovasc Imaging. 2009 Jan; 25(1):101-7.
    View in: PubMed
  41. Rybicki FJ, Otero HJ, Steigner ML, Vorobiof G, Nallamshetty L, Mitsouras D, Ersoy H, Mather RT, Judy PF, Cai T, Coyner K, Schultz K, Whitmore AG, Di Carli MF. Initial evaluation of coronary images from 320-detector row computed tomography. Int J Cardiovasc Imaging. 2008 Jun; 24(5):535-46.
    View in: PubMed
  42. Ware JH, Cai T. Comments on 'Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond' by M. J. Pencina et al., Statistics in Medicine (DOI: 10.1002/sim.2929). Stat Med. 2008 Jan 30; 27(2):185-7.
    View in: PubMed
  43. Lu MT, Cai T, Ersoy H, Whitmore AG, Quiroz R, Goldhaber SZ, Rybicki FJ. Interval increase in right-left ventricular diameter ratios at CT as a predictor of 30-day mortality after acute pulmonary embolism: initial experience. Radiology. 2008 Jan; 246(1):281-7.
    View in: PubMed
  44. Cai T, Cheng S. Robust combination of multiple diagnostic tests for classifying censored event times. Biostatistics. 2008 Apr; 9(2):216-33.
    View in: PubMed
  45. MacKenzie JD, Nazario-Larrieu J, Cai T, Ledbetter MS, Duran-Mendicuti MA, Judy PF, Rybicki FJ. Reduced-dose CT: effect on reader evaluation in detection of pulmonary embolism. AJR Am J Roentgenol. 2007 Dec; 189(6):1371-9.
    View in: PubMed
  46. Ersoy H, Goldhaber SZ, Cai T, Luu T, Rosebrook J, Mulkern R, Rybicki F. Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material. AJR Am J Roentgenol. 2007 May; 188(5):1246-54.
    View in: PubMed
  47. Cai T, Zheng Y. Model checking for ROC regression analysis. Biometrics. 2007 Mar; 63(1):152-63.
    View in: PubMed
  48. Chuang SK, Cai T. Predicting clustered dental implant survival using frailty methods. J Dent Res. 2006 Dec; 85(12):1147-51.
    View in: PubMed
  49. Pepe MS, Cai T, Longton G. Combining predictors for classification using the area under the receiver operating characteristic curve. Biometrics. 2006 Mar; 62(1):221-9.
    View in: PubMed
  50. Zheng Y, Cai T, Feng Z. Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers. Biometrics. 2006 Mar; 62(1):279-87.
    View in: PubMed
  51. Cai T, Gilbert PB, Self SG. Joint inferences on vaccine efficacy against infection and disease with application to the first HIV vaccine efficacy trial. J Biopharm Stat. 2006; 16(4):517-38.
    View in: PubMed
  52. Cai T, Pepe MS, Zheng Y, Lumley T, Jenny NS. The sensitivity and specificity of markers for event times. Biostatistics. 2006 Apr; 7(2):182-97.
    View in: PubMed
  53. Chuang SK, Cai T, Douglass CW, Wei LJ, Dodson TB. Frailty approach for the analysis of clustered failure time observations in dental research. J Dent Res. 2005 Jan; 84(1):54-8.
    View in: PubMed
  54. Cai T, Moskowitz CS. Semi-parametric estimation of the binormal ROC curve for a continuous diagnostic test. Biostatistics. 2004 Oct; 5(4):573-86.
    View in: PubMed
  55. Pepe MS, Cai T. The analysis of placement values for evaluating discriminatory measures. Biometrics. 2004 Jun; 60(2):528-35.
    View in: PubMed
  56. Cai T. Semi-parametric ROC regression analysis with placement values. Biostatistics. 2004 Jan; 5(1):45-60.
    View in: PubMed
  57. Cai T, Betensky RA. Hazard regression for interval-censored data with penalized spline. Biometrics. 2003 Sep; 59(3):570-9.
    View in: PubMed
  58. Rogus JJ, Cai T, Wei LJ. Issues in genomic screening: critical values, sample sizes, and the ability to detect linkage. Genet Epidemiol. 1999; 17 Suppl 1:S697-701.
    View in: PubMed
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